Evelyn C. Avilés, Esther T. Stoeckli,
Morphogens have been identified as guidance cues for postcrossing commissural axons in the spinal cord. Shh has a dual effect on postcrossing commissural axons: a direct repellent effect mediated by ... gradient. Wnts were shown to be attractants for postcrossing commissural axons in both chicken and mouse embryos. ... confirmed a role for the PCP pathway in postcrossing commissural axon guidance also in the chicken embryo. ... signaling is also required for proper guidance of postcrossing commissural axons in the developing spinal cord. Thus, ...
Tópico(s): Nerve injury and regeneration
2015 - Wiley | Developmental Neurobiology
B. Ian Hutchins, Li Li, Katherine Kalil,
... callosum and guide callosal axons after the midline (postcrossing) by Wnt5a-induced repulsion via Ryk receptors. In ... indicator GCaMP2 were electroporated into one cortical hemisphere. Postcrossing callosal axons grew 50% faster than pre-crossing ... of the Ryk receptor reduced outgrowth rates of postcrossing but not precrossing axons by 50% and caused ... callosum CaMKII inhibition reduced the outgrowth rate of postcrossing (but not precrossing) axons and caused severe guidance ... essential for the proper growth and guidance of postcrossing callosal axons which involve axon repulsion through CaMKII.
Tópico(s): Nerve injury and regeneration
2010 - Wiley | Developmental Neurobiology
Nicole H. Wilson, Esther T. Stoeckli,
... the midline•GPC1 genetically interacts with Shh in postcrossing commissural axon guidance•GPC1 regulates expression of Hhip, ... commissural neurons. In turn, Hhip is required for postcrossing axons to respond to a repulsive anteroposterior Shh ... receptor, Hhip, which mediates the repulsive response of postcrossing axons to Shh. Our study characterizes a molecular ...
Tópico(s): Neurogenesis and neuroplasticity mechanisms
2013 - Cell Press | Neuron
... and guide callosal axons after crossing the midline (postcrossing) by Wnt5a-induced repulsion via Ryk (receptor related ... receptor knockdown by siRNA reduces outgrowth rates of postcrossing but not precrossing axons and causes axon misrouting. ... in a decreasing A to P gradient, attracts postcrossing commissural axons (Lyuksyutova et al, 2003). In mice ...
Tópico(s): Nerve injury and regeneration
2012 - Springer Nature | The EMBO Journal
Stacey L. Reeber, Nozomi Sakai, Yuji Nakada, Judy Dumas, Kostantin Dobrenis, Jane E. Johnson, Zaven Kaprielian,
... The upregulation of repulsive Robo1/2 receptors on postcrossing commissural axons, in mammals, presumably allows these axons ... that Robo1/2 inhibit attractive guidance receptors on postcrossing axons, thereby ensuring that decussated axons are selectively ... Robo2, which should block all Robo–ligand interactions, postcrossing commissural axons extend alongside, but do not project ...
Tópico(s): Zebrafish Biomedical Research Applications
2008 - Society for Neuroscience | Journal of Neuroscience
Tianzhi Shu, Vasi Sundaresan, Margaret M. McCarthy, Linda J. Richards,
... assay of hemisected brain slices to specifically analyze postcrossing callosal axons. We find that in the brain, ... the spinal cord, Slit2 mediates both precrossing and postcrossing axonal guidance. Depletion of Slit2 on one side ...
Tópico(s): Nerve injury and regeneration
2003 - Society for Neuroscience | Journal of Neuroscience
Giuseppe Vaccaro, Alexandre Dumoulin, Nikole R. Zuñiga, Christine E. Bandtlow, Esther T. Stoeckli,
... and to interfere with the rostral turn of postcrossing axons. In addition, we also show that NgR1, ... required for midline crossing and subsequent turning of postcrossing axons into the longitudinal axis of the spinal ...
Tópico(s): Neurogenesis and neuroplasticity mechanisms
2022 - Society for Neuroscience | Journal of Neuroscience
Verity Johnson, Harald J. Junge, Zhe Chen,
... crossing and becomes inhibited later to allow crossing. Postcrossing, the ROBO1 and ROBO2 isoforms are disinhibited to prevent midline reentry and to guide postcrossing commissural axons to distinct mediolateral positions.
Tópico(s): Neurogenesis and neuroplasticity mechanisms
2019 - eLife Sciences Publications Ltd | eLife
Vasi Sundaresan, Elvira T. Mambetisaeva, William D. Andrews, Adelaide Annan, Bernd Knöll, Guy Tear, L. H. Bannister,
... disappears, but is strongly upregulated in longitudinally running postcrossing axons. It is also strongly expressed in noncrossing ... while a high level of expression in the postcrossing fibers prevents recrossing. Likewise, Robo‐positive ipsilateral axons ...
Tópico(s): Neurogenesis and neuroplasticity mechanisms
2003 - Wiley | The Journal of Comparative Neurology
Anna I Lyuksyutova, Chin-Chun Lu, Nancy Milanesio, Leslie A. King, Nini Guo, Yanshu Wang, Jeremy Nathans, Marc Tessier‐Lavigne, Yimin Zou,
... the extension of commissural axons after midline crossing (postcrossing). We found that Wnt4 messenger RNA is expressed ... that a directed source of Wnt4 protein attracted postcrossing commissural axons. Commissural axons in mice lacking the ...
Tópico(s): Nerve injury and regeneration
2003 - American Association for the Advancement of Science | Science
Osvaldo Muñoz, Roger Schurch, Jorge Alfredo Ardila‐Rey,
... electrical trees into three stages: initial, valley, and postcrossing, showing different behaviors in terms of discharge and ... Group (b)”) served as an identifier of the postcrossing stage, and therefore an alert of the imminent ... with low PD activity, while growth in the postcrossing stage can be associated with the development of ...
Tópico(s): Electrical Fault Detection and Protection
2023 - Institute of Electrical and Electronics Engineers | IEEE Transactions on Instrumentation and Measurement
Christine E. Holt, Erin M. Schuman,
... is compartmentalized in pre-crossing (Robo3.1) and postcrossing (Robo3.2) axonal segments (Chen et al., 2008Chen ...
Tópico(s): RNA regulation and disease
2013 - Cell Press | Neuron
Patricia T. Yam, Christopher B. Kent, Steves Morin, W. Todd Farmer, Ricardo Alchini, Léa Lepelletier, David Colman, Marc Tessier‐Lavigne, Alyson E. Fournier, Frédéric Charron,
... attraction and prevented the correct anterior turn of postcrossing commissural axons in vivo, an effect mediated through ...
Tópico(s): Nerve injury and regeneration
2012 - Cell Press | Neuron
Ari Z. Zivotofsky, Ehud Eldror, Roi Mandel, Tova Rosenbloom,
... longer than both their precrossing estimation and their postcrossing estimation, which did not significantly differ from each ...
Tópico(s): Older Adults Driving Studies
2012 - SAGE Publishing | Human Factors The Journal of the Human Factors and Ergonomics Society
Jennifer Bonner, Michael Letko, O. Brant Nikolaus, Lisa Krug, Alexandria Cooper, Benjamin Chadwick, Phoebe Conklin, Amy Lim, Chi-Bin Chien, Richard I. Dorsky,
... dcc gene knockdown, ipsilaterally projecting neurons respond to postcrossing guidance cues. Furthermore, DCC inhibits Robo2 function before ...
Tópico(s): Angiogenesis and VEGF in Cancer
2012 - BioMed Central | Neural Development
Zhe Chen, Bryan B. Gore, Hua Long, Le Ma, Marc Tessier‐Lavigne,
... Slit repulsion. Robo3.2 becomes expressed on the postcrossing portion and blocks midline recrossing, favoring Slit repulsion. ...
Tópico(s): Hippo pathway signaling and YAP/TAZ
2008 - Cell Press | Neuron
Bryan B. Gore, Karen Wong, Marc Tessier‐Lavigne,
... exit. In vitro, SCF selectively promotes outgrowth of postcrossing, but not precrossing, commissural axons. Our findings identify ...
Tópico(s): Angiogenesis and VEGF in Cancer
2008 - Cell Press | Neuron
... to cues at the floor plate. For instance, postcrossing axons lose the ability to be attracted to ...
Tópico(s): Neurogenesis and neuroplasticity mechanisms
2000 - Cell Press | Neuron
Produção Nacional
Revisado por pares
Mário Ary Pires‐Neto, Roberto Lent,
... started within the olfactory peduncle and the paleocortex (postcrossing stage). If the existence of pioneer fibers represents ...
Tópico(s): Neonatal and fetal brain pathology
1993 - Elsevier BV | Developmental Brain Research
... started within the olfactory peduncle and the paleocortex (postcrossing stage). If the existence of pioneer fibers represents ...
Tópico(s): Invertebrate Immune Response Mechanisms
1988 - Elsevier BV | Trends in Neurosciences
Nicolas Preitner, Jie Quan, John G. Flanagan,
... levels. Moreover, in vivo axon tracing revealed abnormal postcrossing axon guidance, including trajectories located further than normal ... might help to lock commissural axons on the postcrossing side and prevent them from recrossing. Additionally, if the postcrossing protein concentration steps up to a stable plateau, ...
Tópico(s): Neuroscience and Neuropharmacology Research
2013 - Cell Press | Cell
Satoshi Hara, Takeshi Kaneyama, Yasuyuki Inamata, Ryota Onodera, Ryuichi Shirasaki,
... midline, we analyzed in detail the behavior of postcrossing commissural axons derived from the deep cerebellar nuclei ( ...
Tópico(s): Neuroscience and Neuropharmacology Research
2015 - Wiley | The Journal of Comparative Neurology
... which express distinct receptors on their pre- and postcrossing axon segments. A receptor switch regulates axonal sensitivity ...
Tópico(s): Pain Management and Placebo Effect
2013 - Cell Press | Neuron
Tatyana Shelestova, Анна Калижанова, Marina V. Bedelbayeva,
... research network for transformative education, focusing on the Postcrossing phenomenon to analyze cross-cultural dynamics through authentic ... A mixed-methods approach was used, including a Postcrossing postcard-based questionnaire and personality assessment. The results ... types. This research demonstrates the potential of utilizing Postcrossing in translation studies and educational psychology to promote ...
Tópico(s): EFL/ESL Teaching and Learning
2024 - Taylor & Francis | Cogent Arts and Humanities
Ulyana S. Baimuratova, Anna V. Lyulina,
... texts. The article deals with the texts of Postcrossing project postcards as a full-featured and specific ... the theory of speech genres the corpus of postcrossing postcards texts is subjected to the analysis on ... the structural variability of the genre of the postcrossing postcard. The regularities of the functioning of illocutionary ...
Tópico(s): Cultural, Linguistic, Economic Studies
2020 - | The European Proceedings of Social & Behavioural Sciences
Lubov A. Lasitsa, У. С. Баймуратова,
... the category of time in the texts of Postcrossing postcards. The choice of the object is explained ... are typical for the texts of the project "Postcrossing". The article presents the model of linguistic time characteristic to Postcrossing postcards, describes the grammatical and lexical-semantic markers ...
Tópico(s): linguistics and terminology studies
2018 - | The European Proceedings of Social & Behavioural Sciences
... on precrossing commissural axons is silenced. In contrast, postcrossing commissural axons lose responsiveness to Netrin-1/Shh ... before midline crossing. However, Robo1 expression increases in postcrossing commissural axons, triggering Slit repulsion and simultaneously silencing ... in the spinal cord at both precrossing and postcrossing stages. The introduction of either mouse or chicken ... the distal, but not the proximal, region of postcrossing commissural axons were dramatically increased, which is similar ...
Tópico(s): Developmental Biology and Gene Regulation
2019 - Medknow | Neural Regeneration Research
Vira Svyrydiuk, Anzhela Hordieieva, Valentyna Kyrykylytsia,
... tool have been clarified, in particular blog-, tandem-, postcrossing technologies for optimizing the educational process of the ... the place and role of blog, tandem and postcrossing as learning tools in written communication at the ... presents didactic possibilities of using blog-, tandem-and postcrossing technologies for the formation of intercultural aspect of ...
2024 - Institute for Digitalisation of Education of the NAES of Ukraine | Information Technologies and Learning Tools
... 2. But, curiously, Robo3 is also found on postcrossing axons, when Robo-mediated repulsion is at its ... segment, whereas Robo3.2 was found on the postcrossing segment. Overexpression of 3.1 facilitated crossing but ...
Tópico(s): Neurogenesis and neuroplasticity mechanisms
2008 - Rockefeller University Press | The Journal of Cell Biology
... Taking Taiwan to the World, which used the Postcrossing web app. The results were statistically significant, demonstrating ...
Tópico(s): Innovative Teaching Methods
2024 - | Multidisciplinary Reviews