B.J.C. Janssen, Lucio Gomes, Roman I. Koning, Dmitri I. Svergun, Abraham J. Koster, David C. Fritzinger, Carl‐Wilhelm Vogel, Piet Gros,
... These short-lived protease complexes are formed through pro-convertases, which for the alternative pathway consist of the ... scattering and electron microscopy (EM) data of the pro-convertase formed by human FB and cobra venom factor ( ... between a 'loading' and 'activation' state of the pro-convertase may explain the observed difference between the crystal ... Next, FB binds surface-bound C3b forming the pro-convertase C3bB. When bound to C3b, FB becomes susceptible ... complex We determined the crystal structure of the pro-convertase complex using CVF (1266 residues) purified from cobra ...
Tópico(s): Blood groups and transfusion
2009 - Springer Nature | The EMBO Journal
Dennis E. Hourcade, Lynne M. Mitchell,
... B associates with C3b and Mg2+ forming a pro-convertase C3bB(Mg2+) that is cleaved at a single ... how the double latch is released in the pro-convertase. Here, we introduce single amino acid substitutions into ... and we examine their impact on several different pro-convertase complexes. Our results indicate that loss of the ... B associates with C3b and Mg2+ forming a pro-convertase C3bB(Mg2+) that is cleaved at a single ... how the double latch is released in the pro-convertase. Here, we introduce single amino acid substitutions into ...
Tópico(s): Cellular transport and secretion
2011 - Elsevier BV | Journal of Biological Chemistry
Federico Forneris, Daniel Ricklin, Jin Wu, Αποστολία Τζέκου, Rachel S. Wallace, John D. Lambris, Piet Gros,
... targeted surfaces. We present crystal structures of the pro-convertase C3bB at 4 angstrom resolution and its complex ...
Tópico(s): Cellular transport and secretion
2010 - American Association for the Advancement of Science | Science
Angelino Calderone, Samar Bel‐Hadj, Jessica Drapeau, Viviane El‐Helou, Hugues Gosselin, Robert Clément, Louis Villeneuve,
... myofibroblasts synthesized ANP, BNP, adrenomedullin, and expressed the pro‐convertase corin. Constitutive and sympathetic‐driven natriuretic peptide synthesis ...
Tópico(s): Cardiac Structural Anomalies and Repair
2005 - Wiley | Journal of Cellular Physiology
Jordan L. Woehl, Daisuke Takahashi, Alvaro I. Herrera, Brian V. Geisbrecht, Om Prakash,
... to inhibit formation of the CP/LP C3 pro-convertase. Secreted full-length, mature Eap consists of four ~ ...
Tópico(s): Bacterial biofilms and quorum sensing
2016 - Springer Science+Business Media | Biomolecular NMR Assignments
Jordan L. Woehl, Kasra X. Ramyar, Benjamin B. Katz, John K. Walker, Brian V. Geisbrecht,
... formation of the classical and lectin pathway C3 pro‐convertase. Although an underlying mechanism has been identified, the ...
Tópico(s): Clostridium difficile and Clostridium perfringens research
2017 - Wiley | Protein Science
Ramon M. van den Bos, Nicholas M. Pearce, J.C.M. Granneman, T. Harma C. Brondijk, Piet Gros,
... fragment Bb, and thereby enhance formation of C3bB pro-convertases and stabilize C3bBb convertases. In addition, properdin TSR6 ...
Tópico(s): Erythrocyte Function and Pathophysiology
2019 - Frontiers Media | Frontiers in Immunology
... hypothalamic TRH expression, TRH transcription via stimulation of pro-convertase 1 and 2 expression, which lead to enhanced ...
Tópico(s): Growth Hormone and Insulin-like Growth Factors
2016 - | Acta Endocrinologica (Bucharest)
Maria Radanova, Galya Mihaylova, Diana Ivanova, Marie V. Daugan, Valetin Lazarov, Lubka T. Roumenina, Vasil Vasilev,
... to C3b, the C3 convertase C3bBb and the pro-convertase C3bB, evaluated by surface plasmon resonance. In conclusion, ...
Tópico(s): Platelet Disorders and Treatments
2020 - Oxford University Press | Clinical & Experimental Immunology
Gilles Phan, Han Remaut, William J. Allen, Sebastian Geibel, Andrey A. Lebedev, Nadine S. Henderson, David G. Thanassi, Gabriel Waksman,
... interacts with surface-bound C3b to form the pro-convertase C3bB, which is then specifically cleaved by the ... We present here the crystal structures of the pro-convertase complex C3bB, formed by C3b (12 domains, 160 ...
Tópico(s): Enzyme Structure and Function
2011 - Wiley | Acta Crystallographica Section A Foundations of Crystallography
Roland Beckmann, Jens Frauenfeld, James C. Gumbart, Klaus Schulten,
... interacts with surface-bound C3b to form the pro-convertase C3bB, which is then specifically cleaved by the ... We present here the crystal structures of the pro-convertase complex C3bB, formed by C3b (12 domains, 160 ...
Tópico(s): RNA and protein synthesis mechanisms
2011 - Wiley | Acta Crystallographica Section A Foundations of Crystallography
Federico Forneris, Michael A. Hadders, Juanjuan Wu, Piet Gros,
... complement activation and regulation: the structures of the pro-convertase of the alternative pathway C3bB and C3bBD*, and ... pathway of complement, C5b6.The structures of the pro-convertase complexes highlight the equilibrium between an initial (closed/ ...
Tópico(s): Carbohydrate Chemistry and Synthesis
2012 - Wiley | Acta Crystallographica Section A Foundations of Crystallography
Ivo Tews, Gabriela Guédez, Volker Windeisen, Irmgard Sinning, Katharina Hipp, Bettina Böttcher, Martin Gengenbacher, Bianca Derrer, Barbara Kappes,
... complement activation and regulation: the structures of the pro-convertase of the alternative pathway C3bB and C3bBD*, and ... pathway of complement, C5b6.The structures of the pro-convertase complexes highlight the equilibrium between an initial (closed/ ...
Tópico(s): Cancer-related Molecular Pathways
2012 - Wiley | Acta Crystallographica Section A Foundations of Crystallography
Agnieszka Nagorska, Andreas Zaucker, Finnlay Lambert, Angus Inman, Sara Toral-Pérez, Jan Gorodkin, Yue Wan, Michael Smutny, Karuna Sampath,
... and valve formation are not fully understood. The pro-convertase FurinA functions in heart development across vertebrates. How ...
Tópico(s): RNA and protein synthesis mechanisms
2023 - The Company of Biologists | Development
... Proprotein Convertase Subtilisin Kexin type 9) est une pro-convertase qui est majoritairement exprimée et sécrétée par le ...
Tópico(s): Lipid metabolism and disorders
2021 - Elsevier BV | Annales d Endocrinologie