1995 - Gale Group | Chatham House Online Part 2
... External Affairs (India), “Joint Statement, Visit of Mr. Pranab Mukherjee, Minister of Defense to Japan,” May 26, 2006. ... htm?dtl/6159/Joint+Statement+Visit+of+Mr+Pranab+Mukherjee+Minister+of+Defence+to+Japan67. MOFA, “Joint Statement ...
Tópico(s): Global trade and economics
2014 - Taylor & Francis | Asian Security
George J. Gilboy, Eric Heginbotham,
... Government of India, "Address by H. E. Mr. Pranab Mukherjee, Minister of External Affairs, at a Seminar on " ... Speeches-Statements.htm?dtl/1768/Address+by+HEMr+Pranab+Mukherjee+Minister+of+External+Affairs+at+a+Seminar+on+ ...
Tópico(s): Asian Geopolitics and Ethnography
2013 - Taylor & Francis | The Washington Quarterly
... via http://www.mea.gov.in. 24. See Pranab Mukherjee, concluding address to the Seventh Asian Security Conference, ...
Tópico(s): International Relations and Foreign Policy
2013 - Routledge | India Review
... Policy', Maritime Affairs 5/2 (Winter 2009), 15; Pranab Mukherjee (Minister for External Affairs), 'International Relations and Maritime ...
Tópico(s): International Relations and Foreign Policy
2013 - Taylor & Francis | Journal of Strategic Studies
... No. 5 (December 2009), pp. 597–618. 28. Pranab Mukherjee, Address to the 5th IISS Asian Security Summit, ...
Tópico(s): Global trade and economics
2013 - Routledge | India Review
... 530516879. 23. “Remarks by External Affairs Minister Mr. Pranab Mukherjee at the Annual Dinner of the Association of ...
Tópico(s): Bangladesh Politics, Society, and Development
2011 - Taylor & Francis | The Washington Quarterly
... MEA, Address by Minister of External Affairs Shri Pranab Mukherjee. MEA, Foreign Secretary's Shyam Saran's Speech ...
Tópico(s): South Asian Studies and Conflicts
2011 - Taylor & Francis | Democratization
... crore). This was inaugurated by External Affairs Minister Pranab Mukherjee in January 2009. 49. Vladimir Radyuhin, 'SCO: Towards ...
Tópico(s): Terrorism, Counterterrorism, and Political Violence
2010 - Taylor & Francis | Strategic Analysis
... was never honoured --Statement by Indian Foreign Minister Pranab Mukherjee, 50th Session of the U.N. General Assembly ( ...
Tópico(s): Nuclear Issues and Defense
1997 - Columbia University | Journal of international affairs
Henry Paulus, Nilima Sarkar, Pranab K. Mukherjee, Donna Langley, В. Т. Иванов, E.N. Shepel, William R. Veatch,
... permeability, and ribonucleic acid polymeraseHenry Paulus, Nilima Sarkar, Pranab K. Mukherjee, Donna Langley, V. T. Ivanov, E. N. Shepel, ...
Tópico(s): RNA and protein synthesis mechanisms
1979 - American Chemical Society | Biochemistry
... sanitation as an intact function of surviving. President Pranab Mukherjee in his address to Parliament in June 2014, ...
Tópico(s): Sustainable Development and Environmental Policy
2015 - Scientific Research Publishing | Journal of Geoscience and Environment Protection
Jyotsna Chandra, Thomas S. McCormick, Yoshifumi Imamura, Pranab K. Mukherjee, Mahmoud A. Ghannoum,
ABSTRACT Monocytes and macrophages are the cell types most commonly associated with the innate immune response against Candida albicans infection. Interactions between the host immune system and Candida organisms have been investigated for planktonic Candida cells, but no studies have addressed these interactions in a biofilm environment. In this study, for the first time, we evaluated the ability of C. albicans to form biofilms in the presence or absence of adherent peripheral blood mononuclear ...
Tópico(s): Pneumocystis jirovecii pneumonia detection and treatment
2007 - American Society for Microbiology | Infection and Immunity
Pranab K. Mukherjee, Victor L. Marcheselli, Juan Carlos de Rivero Vaccari, William C. Gordon, Fannie E. Jackson, Nicolás G. Bazán,
Photoreceptor cell (rods and cones) renewal is accompanied by intermittent shedding of the distal tips of the outer segment followed by their phagocytosis in the retinal pigment epithelial (RPE) cells. This renewal is essential for vision, and it is thought that it fosters survival of photoreceptors and of RPE cells. However, no specific survival messenger/mediators have as yet been identified. We show here that photoreceptor outer segment (POS) phagocytosis markedly attenuates oxidative stress-induced ...
Tópico(s): Retinoids in leukemia and cellular processes
2007 - National Academy of Sciences | Proceedings of the National Academy of Sciences
Kathleen M. Yeater, Jyotsna Chandra, Georgina Cheng, Pranab K. Mukherjee, Xiaomin Zhao, Sandra L. Rodriguez‐Zas, Kurt E. Kwast, Mahmoud A. Ghannoum, Lois L. Hoyer,
Microarrays were used to identify changes in gene expression associated with Candida albicans biofilm development. Two biofilm substrates (denture and catheter), and two C. albicans strains for each substrate, were tested to remove model- and strain-dependent variability from the overall dataset. Three biofilm developmental phases were examined: early (6 h), intermediate (12 h), and mature (48 h). Planktonic specimens were collected at the same time points. Data analysis focused primarily on gene expression ...
Tópico(s): Bacterial biofilms and quorum sensing
2007 - Microbiology Society | Microbiology
Pranab K. Mukherjee, Amanpreet Singh Chawla, Marco S. Loayza, Nicolás G. Bazán,
The identification of neuroprotectin D1 (NPD1), a biosynthetic product of docosahexaenoic acid (DHA), in brain and retina as well as the characterization of its bioactivity, is generating a renewed interest in the functional role and pathophysiological significance of omega-3 fatty acids in the central nervous system. Neurotrophins, particularly pigment epithelium-derived factor (PEDF), induce NPD1 synthesis and its polarized apical secretion, implying paracrine and autocrine bioactivity of this lipid ...
Tópico(s): Fatty Acid Research and Health
2007 - Elsevier BV | Prostaglandins Leukotrienes and Essential Fatty Acids
Pranab K. Mukherjee, Sotohy Mohamed, Jyotsna Chandra, Duncan M. Kuhn, Shuqing Liu, Omar Antar, Ryan Munyon, Aaron P. Mitchell, David R. Andes, Mark R. Chance, Mahmoud Rouabhia, Mahmoud A. Ghannoum,
Candida biofilms formed on indwelling medical devices are increasingly associated with severe infections. In this study, we used proteomics and Western and Northern blotting analyses to demonstrate that alcohol dehydrogenase (ADH) is downregulated in Candida biofilms. Disruption of ADH1 significantly (P = 0.0046) enhanced the ability of Candida albicans to form biofilm. Confocal scanning laser microscopy showed that the adh1 mutant formed thicker biofilm than the parent strain (210 microm and 140 microm, ...
Tópico(s): Oral microbiology and periodontitis research
2006 - American Society for Microbiology | Infection and Immunity
Anthony L. Vaccarino, Dennis Paúl, Pranab K. Mukherjee, Elena Turco, Victor L. Marcheselli, Liang Xu, Mark L. Trudell, Jesus Minguez, M.P. Matía, Carlos Sunkel, Julio Álvarez‐Buílla, Nicolás G. Bazán,
Tópico(s): Pharmacological Effects of Natural Compounds
2006 - Elsevier BV | Bioorganic & Medicinal Chemistry
Jyotsna Chandra, Jasmine Patel, Jian Li, Guangyin Zhou, Pranab K. Mukherjee, Thomas S. McCormick, James M. Anderson, Mahmoud A. Ghannoum,
ABSTRACT Candida albicans biofilms form on indwelling medical devices (e.g., denture acrylic or intravenous catheters) and are associated with both oral and invasive candidiasis. Here, we determined whether surface modifications of polyetherurethane (Elasthane 80A [E80A]), polycarbonateurethane, and poly(ethyleneterephthalate) (PET) can influence fungal biofilm formation. Polyurethanes were modified by adding 6% polyethylene oxide (6PEO), 6% fluorocarbon, or silicone, while the PET surface was modified ...
Tópico(s): Antimicrobial agents and applications
2005 - American Society for Microbiology | Applied and Environmental Microbiology
Pranab K. Mukherjee, Guangyin Zhou, Ryan Munyon, Mahmoud A. Ghannoum,
Biofilms are colonies of microbial cells encased in a self-produced organic polymeric matrix and represent a common mode of microbial growth. Microbes growing as biofilm are highly resistant to commonly used antimicrobial drugs. Recently, microbial biofilms have gained prominence because of the increase in infections related to indwelling medical devices (IMD). Candidaalbicans, the pathogenic fungus which is a major cause of morbidity and mortality in blood stream infections, is the most common fungal ...
Tópico(s): Legionella and Acanthamoeba research
2005 - Oxford University Press | Medical Mycology
Pranab K. Mukherjee, Daniel J. Sheehan, Christopher A. Hitchcock, Mahmoud A. Ghannoum,
SUMMARY The persistence of high morbidity and mortality from systemic fungal infections despite the availability of novel antifungals points to the need for effective treatment strategies. Treatment of invasive fungal infections is often hampered by drug toxicity, tolerability, and specificity issues, and added complications often arise due to the lack of diagnostic tests and to treatment complexities. Combination therapy has been suggested as a possible approach to improve treatment outcome. In ...
Tópico(s): Nail Diseases and Treatments
2005 - American Society for Microbiology | Clinical Microbiology Reviews
Vittorio Colangelo, William C. Gordon, Pranab K. Mukherjee, Pankaj Trivedi, Paulo Ottino,
The response of the inducible isoform of the prostaglandin H2 synthase (COX-2) and the c-Jun N-terminal kinase (JNK) in post-ischemic neuronal damage was assessed in a model of ischemic tolerance in Mongolian Gerbils. After a single 6-min bilateral carotid occlusion, histological damage was evident in the CA1 region of hippocampus, correlated with a high expression of JNK and COX-2 mRNA. However, in the group of animals with a 2-min ischemia and the tolerance group, in which a 2-min bilateral carotid ...
Tópico(s): Traditional Chinese Medicine Analysis
2004 - Elsevier BV | Brain Research
Ningfeng Tang, Li Liu, Kefei Kang, Pranab K. Mukherjee, Masakazu Takahara, Guofen Chen, Thomas S. McCormick, Kevin D. Cooper, Mahmoud Ghannoum,
ABSTRACT Our previous data demonstrated that live Candida albicans inhibits interleukin-12 (IL-12) production by human monocytes. Here we explored whether C. albicans inhibits IL-12 via a released factor and whether the inhibition is mediated via mitogen-activated protein kinase (MAPK) regulation. Supernatant fluids were obtained from cultured C. albicans (SC5314) as well as cultured Saccharomyces cerevisiae after 20 h of incubation. At 2 h postincubation of monocytes with heat-killed C. albicans (HKCA) ( ...
Tópico(s): Immune Response and Inflammation
2004 - American Society for Microbiology | Infection and Immunity
Clayton B. Green, Georgina Cheng, Jyotsna Chandra, Pranab K. Mukherjee, Mahmoud A. Ghannoum, Lois L. Hoyer,
An RT-PCR assay was developed to analyse expression patterns of genes in the Candida albicans ALS ( a gglutinin- l ike s equence) family. Inoculation of a reconstituted human buccal epithelium (RHE) model of mucocutaneous candidiasis with strain SC5314 showed destruction of the epithelial layer by C. albicans and also formation of an upper fungal layer that had characteristics similar to a biofilm. RT-PCR analysis of total RNA samples extracted from C. albicans -inoculated buccal RHE showed that ALS1 , ...
Tópico(s): Oral microbiology and periodontitis research
2004 - Microbiology Society | Microbiology
Matthew K. Schinabeck, Lisa Long, Mohammad Ashraf Hossain, Jyotsna Chandra, Pranab K. Mukherjee, Sotohy Mohamed, Mahmoud A. Ghannoum,
ABSTRACT Catheter-related infections due to Candida albicans biofilms are a leading cause of fungal nosocomial bloodstream infection. In this paper, we describe the development of a model of catheter-associated infection with C. albicans biofilms and show that antifungal lock therapy with liposomal amphotericin B is an effective treatment strategy for these infections. Silicone catheters surgically placed in New Zealand White rabbits were infected with C. albicans , and the rabbits were randomized ...
Tópico(s): Nosocomial Infections in ICU
2004 - American Society for Microbiology | Antimicrobial Agents and Chemotherapy
Duncan M. Kuhn, Pranab K. Mukherjee, Thomas A. Clark, Claude Pujol, Jyotsna Chandra, Rana Hajjeh, David W. Warnock, David R. Soll, Mahmoud A. Ghannoum,
Abstract Candida parapsilosis is an important non-albicans species which infects hospitalized patients. No studies have correlated outbreak infections of C. parapsilosis with multiple virulence factors. We used DNA fingerprinting to determine genetic variability among isolates from a C. parapsilosis outbreak and from our clinical database. We compared phenotypic markers of pathogenesis, including adherence, biofilm formation, and protein secretion (secretory aspartic protease [SAP] and phospholipase). ...
Tópico(s): Oral microbiology and periodontitis research
2004 - Centers for Disease Control and Prevention | Emerging infectious diseases
Mahmoud A. Ghannoum, Mozammal Hossain, L. Long, Sotohy Mohamed, Gustavo Reyes, Pranab K. Mukherjee,
AbstractAbstractDermatophytoses are known to cause considerable discomfort, cosmetic prob-lems and financial loss that have been recognized as a significant health concern worldwide. Since currently available antifungal agents have limitations in their effi-cacy, new agents are being developed. This study was undertaken to optimize an in vivo model of experimental dermatophytosis for evaluation of the efficacy of anti-fungal compounds. Guinea pigs were infected with different inocula of T. menta- ...
Tópico(s): Plant Pathogens and Fungal Diseases
2004 - Taylor & Francis | Journal of Chemotherapy
Florian Rieder, Pranab K. Mukherjee, William J. Massey, Yan Wang, Claudio Fiocchi,
Background Intestinal fibrosis resulting in stricture formation and obstruction in Crohn’s disease (CD) and increased wall stiffness leading to symptoms in ulcerative colitis (UC) is among the largest unmet needs in inflammatory bowel disease (IBD). Fibrosis is caused by a multifactorial and complex process involving immune and non-immune cells, their soluble mediators and exposure to luminal contents, such as microbiota and environmental factors. To date, no antifibrotic therapy is available. Some ...
Tópico(s): Pancreatic and Hepatic Oncology Research
2024 - BMJ | Gut
Pranab K. Mukherjee, Quang Tam Nguyen, Jiannan Li, Shuai Zhao, Stephen M. Christensen, Gail West, Jyotsna Chandra, Ilyssa O. Gordon, Sinan Lin, Jie Wang, Ren Mao, D. Czarnecki, Carla Rayan, Idan Goren, Suhanti Banerjee, Prerna Kotak, Thomas Plesec, Samir Lal, Thomas Fabre, Shoh Asano, Kathryn Bound, Kevin M. Hart, Chanyoung Park, Robert Martinez, Ken Dower, Thomas A. Wynn, Shaomin Hu, Nayden G. Naydenov, Martin Decaris, Scott Turner, Stefan D. Holubar, Scott R. Steele, Claudio Fiocchi, Andrei I. Ivanov, Kellie M. Kravarik, Florian Rieder,
Background & Aims Fibroblasts play a key role in stricture formation in Crohn's disease (CD) but understanding its pathogenesis requires a systems-level investigation to uncover new treatment targets. We studied full-thickness CD tissues to characterize fibroblast heterogeneity and function by generating the first single-cell RNA sequencing (scRNAseq) atlas of strictured bowel and providing proof of principle for therapeutic target validation. Methods We performed scRNAseq of 13 fresh full-thickness CD resections ...
Tópico(s): Single-cell and spatial transcriptomics
2023 - Elsevier BV | Gastroenterology
Sinan Lin, Alessandro Musso, Jie Wang, Pranab K. Mukherjee, Gail West, Ren Mao, Ruishen Lyu, Jiannan Li, Shuai Zhao, Michael Elias, Yael Haberman, Lee A. Denson, Subra Kugathasan, Minhu Chen, Doug Czarnecki, Dina Dejanovic, Hongnga T. Le, Jyotsna Chandra, Jeremy M. Lipman, Scott R. Steele, Quang Tam Nguyen, Claudio Fiocchi, Florian Rieder,
Objective: Inflammatory bowel diseases (IBD) cause chronic intestinal damage and extracellular matrix (ECM) remodeling. The ECM may play an active role in inflammation by modulating immune cell functions, including cell adhesion, but this hypothesis has not been tested in IBD. Design: Primary human intestinal myofibroblast (HIMF)-derived ECM from IBD and controls, 3D decellularized colon or ECM molecule-coated scaffolds were tested for their adhesiveness for T cells. Matrisome was analysed via proteomics. ...
Tópico(s): Cancer Immunotherapy and Biomarkers
2022 - Elsevier BV | Matrix Biology