Directory of Open Access Books (DOAB)
Precis (Letters Private and Promiscuous), 1800
0000 - Gale Group | NCCO BritishPolitics
Melisa W.Y. Ho, Xiaonian Yang, Mark A. Carew, Tong Zhang, Len Hua, Yong‐Uk Kwon, Sung‐Kee Chung, Stephan Adelt, Günter Vogel, Andrew M. Riley, Barry V. L. Potter, Stephen B. Shears,
... S.B. Multitasking in signal transduction by a promiscuous human Ins(3,4,5,6)P4 1- ... S.B. Multitasking in signal transduction by a promiscuous human Ins(3,4,5,6)P4 1- ... S.B. Multitasking in signal transduction by a promiscuous human Ins(3,4,5,6)P4 1- ... S.B. Multitasking in signal transduction by a promiscuous human Ins(3,4,5,6)P4 1- ... S.B. Multitasking in signal transduction by a promiscuous human Ins(3,4,5,6)P4 1- ... S.B. Multitasking in signal transduction by a promiscuous human Ins(3,4,5,6)P4 1- ... S.B. Multitasking in signal transduction by a promiscuous human Ins(3,4,5,6)P4 1- ...
Tópico(s): Protein Kinase Regulation and GTPase Signaling
2002 - Elsevier BV | Current Biology
Precis (Letters Private and Promiscuous), 1800
0000 - Gale Group | NCCO BritishPolitics
Martha Lucinda Contreras-Zentella, Guillermo Mendoza, Jorge Membrillo‐Hernández, J. E. Escamilla,
... the first reported example of an enzymatically active promiscuous oxidase resulting from the simultaneous substitution of its ... the first reported example of an enzymatically active promiscuous oxidase resulting from the simultaneous substitution of its ... A, whereas O2-limited conditions lead to a promiscuous substitution of heme A by heme O. This ... these novel oxidases was not further explored. Several promiscuous oxidases with single heme substitutions have been purified ... Google Scholar). To our knowledge, an enzymatically active promiscuous oxidase bearing double heme substitution has yet to ...
Tópico(s): Electrochemical sensors and biosensors
2003 - Elsevier BV | Journal of Biological Chemistry
Precis (Letters Private and Promiscuous), 1800
0000 - Gale Group | NCCO BritishPolitics
Malay Kumar Basu, Liran Carmel, Igor B. Rogozin, Eugene V. Koonin,
... in diverse domain architectures and can be considered “promiscuous.” These promiscuous domains are, typically, involved in protein–protein interactions ... signal transduction. A systematic comparative-genomic analysis of promiscuous domains in eukaryotes is described. Two quantitative measures ... eukaryotes. Altogether, 215 domains are identified as strongly promiscuous. The fraction of promiscuous domains in animals is shown to be significantly ... feature of eukaryotic proteins, with few domains remaining promiscuous throughout the evolution of eukaryotes. Some domains appear ...
Tópico(s): Biochemical and Structural Characterization
2008 - Cold Spring Harbor Laboratory Press | Genome Research
Precis (Letters Private and Promiscuous), 1800 Letter. To John King Esq. General Post Office.
0000 - Gale Group | NCCO BritishPolitics
Saravanan Matheshwaran, Kommireddy Vasu, Soumitra Ghosh, Valakunja Nagaraja,
... discriminator of DNA sequences, cleaving DNA in a promiscuous manner in the presence of Mg2+. Unlike most ... Among these metal ions, Mg2+ and Mn2+ induce promiscuous cleavage by the enzyme, whereas Ca2+-bound enzyme ... cleavage and suppress the Mg2+- and Mn2+-mediated promiscuous behavior of the enzyme. This is the first ... discriminator of DNA sequences, cleaving DNA in a promiscuous manner in the presence of Mg2+. Unlike most ... Among these metal ions, Mg2+ and Mn2+ induce promiscuous cleavage by the enzyme, whereas Ca2+-bound enzyme ...
Tópico(s): Advanced biosensing and bioanalysis techniques
2007 - Elsevier BV | Journal of Biological Chemistry
Precis (Letters Private and Promiscuous), 1800
0000 - Gale Group | NCCO BritishPolitics
... Google Scholar). This phenomenon is referred to as "promiscuous gene expression," and it has evolved to facilitate ... transcription factor Fezf2 as a key driver of promiscuous gene expression in mTECs, essential to prevent spontaneous ... Google Scholar). Strikingly, however, it turned out that promiscuous gene expression was not fully abolished in the ... Google Scholar), while largely ignoring how Aire-independent promiscuous gene expression is regulated. Here, Takaba et al., ... hypothesize that any Aire-independent additional regulators of promiscuous gene expression should be differentially expressed between mTECs ...
Tópico(s): Diabetes and associated disorders
2015 - Cell Press | Cell
Precis (Letters Private and Promiscuous), 1800 Letter. From James Court. Trinity - House London.
0000 - Gale Group | NCCO BritishPolitics
Sizhuang Yan, Rui G. Rodrigues, Diego Cahn-Hidalgo, Thomas J. Walsh, David D. Roberts,
... with similar IC50 values, suggesting that a single promiscuous receptor recognizes these three proteins. Competitive binding studies ... chromatography on immobilized fibronectin. Thus, hemoglobin induces both promiscuous and specific receptors for extracellular matrix proteins and, ... with similar IC50 values, suggesting that a single promiscuous receptor recognizes these three proteins. Competitive binding studies ... chromatography on immobilized fibronectin. Thus, hemoglobin induces both promiscuous and specific receptors for extracellular matrix proteins and, ...
Tópico(s): Protease and Inhibitor Mechanisms
1998 - Elsevier BV | Journal of Biological Chemistry
Precis (Letters Private and Promiscuous), 1800
0000 - Gale Group | NCCO BritishPolitics
Gabriela I. Guzmán, Troy E. Sandberg, Ryan A. LaCroix, Ákos Nyerges, Henrietta Papp, Markus de Raad, Zachary A. King, Ying Hefner, Trent R. Northen, Richard A. Notebaart, Csaba Pál, Bernhard Ø. Palsson, Balázs Papp, Adam M. Feist,
... that novel enzyme functions evolved from low-level promiscuous activities in ancestral enzymes. Yet, the evolutionary dynamics ... remains untested whether knowledge of an organism's promiscuous reaction set, or underground metabolism, can aid in ... D-arabinose, m-tartrate, and monomethyl succinate. Altered promiscuous activities were shown to be directly involved in ... nature and single mutation events related to a promiscuous activity can be sufficient to support growth while ... predict adaptation to non-native carbon sources through promiscuous enzyme activities. Laboratory evolution can be used to ...
Tópico(s): Fungal and yeast genetics research
2019 - Springer Nature | Molecular Systems Biology
Precis (Letters Private and Promiscuous), 1800 Letter. From H. C. Comleef. Mansion House.
0000 - Gale Group | NCCO BritishPolitics
Christian Feldmann, Jürgen Bajorath,
... complex multifactorial diseases [1–4]. The use of promiscuous compounds for therapeutic intervention gives rise to polypharmacology [ ... not mutually exclusive. Several studies have revealed that promiscuous ligands often bind to similar binding sites in ... favor compound binding to related targets. However, many promiscuous compounds interact with targets from different families, including ... x-ray structures of complexes between proteins and promiscuous compounds have been determined, but binding characteristics of ...
Tópico(s): Synthesis and biological activity
2020 - Future Science Ltd | Future Drug Discovery
Precis (Letters Private and Promiscuous), 1800
0000 - Gale Group | NCCO BritishPolitics
Karol Buda, C.M. Miton, Xingyu Cara Fan, Nobuhiko Tokuriki,
... effects of a mutation on the normal and promiscuous activities of orthologs: implications for natural and directed ... this number can be further multiplied when taking promiscuous activities into account [88.Copley S.D. Shining ... this number can be further multiplied when taking promiscuous activities into account [88.Copley S.D. Shining ... function often starts by recruiting and optimizing a promiscuous function (Box 2). Hence, the initial level of ... starting points (Figure 2A).Box 2The evolvability of promiscuous enzyme networksThe evolution of new enzyme functions is ...
Tópico(s): Microbial Metabolic Engineering and Bioproduction
2023 - Elsevier BV | Trends in Biochemical Sciences
William Gillier, Robert Wilson, Wm Morlers,
Precis (Letters Private and Promiscuous), 1800 Letter. From William Gillier, Robert Wilson, Wm Morlers. London.
0000 - Gale Group | NCCO BritishPolitics
... ScholarRepeated exposures to a critical epitope may generate promiscuous T lymphocytes through molecular mimicry, and these activated ... 7Hammer J. Valsasnini P. Tolba K. et al.Promiscuous and allele-specific anchors in HLA-DR-binding ... to a peptide antigen involves both specific and promiscuous interactions between the T cell receptor, peptide, and ... 7Hammer J. Valsasnini P. Tolba K. et al.Promiscuous and allele-specific anchors in HLA-DR-binding ... to a peptide antigen involves both specific and promiscuous interactions between the T cell receptor, peptide, and ...
Tópico(s): Systemic Lupus Erythematosus Research
2008 - Elsevier BV | Clinical Gastroenterology and Hepatology
Precis (Letters Private and Promiscuous), 1800
0000 - Gale Group | NCCO BritishPolitics
Philip M. Kim, Andrea Sboner, Yu Xia, Mark Gerstein,
... structured Disordered regions have been implicated in mediating promiscuous binding (Dunker et al, 2005; Patil and Nakamura, ... Also, singlish-interface hubs are known to be promiscuous binders and their interfaces presumably interact with many ... is due to their interfaces being involved in promiscuous binding (Singh et al, 2007). Therefore, their binding ... questions: (1) with structured interfaces, how is the promiscuous binding of singlish-interface hubs mediated? (2) What ... to their higher level of disorder, if not promiscuous binding at the binding interface? Higher disorder in ...
Tópico(s): Photosynthetic Processes and Mechanisms
2008 - Springer Nature | Molecular Systems Biology
Precis (Letters Private and Promiscuous), 1800 Letter. From Auckland. To F. Fceeling Esq. Eden.
0000 - Gale Group | NCCO BritishPolitics
... other domains in human proteins. In this work, promiscuous domains were first identified from the yeast genome. Then, we sought to determine what roles promiscuous domains might play in the PPI network. Mapping the promiscuous domains onto the proteins in this network revealed ... knowledge, the hub proteins were significantly enriched with promiscuous domains. We also found that the set of ... not the same set as those proteins with promiscuous domains, although there was some overlap. Analysis of ... the network increased significantly after deleting proteins with promiscuous domains. This indicated that communication between two proteins ...
Tópico(s): Microbial Metabolic Engineering and Bioproduction
2011 - Royal Society of Chemistry | Molecular BioSystems
Precis (Letters Private and Promiscuous), 1800
0000 - Gale Group | NCCO BritishPolitics
Éva Szegezdi, Almer M. van der Sloot, Devalingam Mahalingam, Lynda O’Leary, Robbert H. Cool, Inés G. Muñoz, Guillermo Montoya, Wim J. Quax, Steven de Jong, Afshin Samali, Luís Serrano,
... in case of hetero-oligomerizing receptors of a promiscuous ligand largely depend on the relative amounts of its receptors. Promiscuous ligands can trigger the formation of nonproductive receptor ... results suggest that control of signaling pathways by promiscuous ligands could result in apparent slow biological kinetics ... in case of hetero-oligomerizing receptors of a promiscuous ligand largely depend on the relative amounts of its receptors. Promiscuous ligands can trigger the formation of nonproductive receptor ...
Tópico(s): Cytokine Signaling Pathways and Interactions
2012 - Elsevier BV | Molecular & Cellular Proteomics
Precis (Letters Private and Promiscuous), 1800 Letter. To J. King Esq.
0000 - Gale Group | NCCO BritishPolitics
Ariel Fernández, Dan S. Tawfik, Ben Berkhout, Rogier W. Sanders, Andrzej Kloczkowski, Taner Z. Sen, Bob Jernigan, Dan S. Tawfik, Ben Berkhout, Rogier W. Sanders, Andrzej Kloczkowski, Taner Z. Sen, Robert L. Jernigan,
... blocking the protein activity and is termed a promiscuous function to distinguish from the protein's native ... evolved naturally for drug association or drug resistance. Promiscuous protein functions exhibit unique traits of evolutionary adaptability, ... effects on native functions, but large effects on promiscuous function; for example, an evolving protein could become ... dismisses the notion that drug binding is quintessentially promiscuous, even though in principle, proteins did not evolve ... be separate protein domains that one could term promiscuous domains. While acknowledging that drugs may bind promiscuously ...
Tópico(s): Monoclonal and Polyclonal Antibodies Research
2005 - Taylor & Francis | Journal of Biomolecular Structure and Dynamics