Emily Roltsch, Leigh A. Holcomb, Keith A. Young, Alexander Marks, Danna B. Zimmer,
... was used to inhibit S100B function in the PSAPP AD mouse model. The PSAPP/S100B-/- line was generated by crossing PSAPP double transgenic males with S100B-/- females and maintained as PSAPP/S100B+/- crosses. Congo red staining was used to ... number and plaque size in 6 month old PSAPP and PSAPP/S100B-/- littermates. The microglial marker Iba1 and astrocytic ... assess the spatial distribution of S100B in the PSAPP line.PSAPP/S100B-/- mice exhibited a regionally selective decrease in ... but not hippocampal plaque load when compared to PSAPP littermates. This regionally selective reduction in plaque load ...
Tópico(s): Protease and Inhibitor Mechanisms
2010 - BioMed Central | Journal of Neuroinflammation
Jon T. Brown, Jeannie Chin, Steven C. Leiser, Menelas N. Pangalos, Andrew D. Randall,
... Patch clamp measurements from CA1 pyramidal cells of PSAPP and wild type mice were employed to investigate ... such network hyperfunction. At approximately 10 months, when PSAPP mice have a substantial central nervous system Aβ ... potential and input resistance were genotype-independent. However, PSAPP mice exhibited a substantially more prominent action potential ( ... The spike afterdepolarization (ADP) was also larger in PSAPP mice. The rate of rise, width and height of APs were reduced in PSAPP animals; AP threshold was unaltered. Voltage-clamp recordings ...
Tópico(s): Cholinesterase and Neurodegenerative Diseases
2011 - Elsevier BV | Neurobiology of Aging
Keiko Takasu, Kazuki Niidome, Minoru Hasegawa, Koichi Ogawa,
... using acute hippocampal slices of AD model mice (PSAPP transgenic mice). We found a decrease in kainate-induced gamma oscillations in slices from PSAPP mice, accompanied with the increased activity of fast ... named vorinostat) restored deficits of gamma oscillation in PSAPP mice, accompanied with rescue of activity of fast ... inhibition, rescued the deficits in gamma oscillations in PSAPP mice. These results suggested a novel mechanism in ... HDAC inhibition improved impairment of gamma oscillations in PSAPP mice by restoring the activity of fast spiking ...
Tópico(s): Neuroscience and Neuropharmacology Research
2021 - Frontiers Media | Frontiers in Molecular Neuroscience
Jon Valla, Lonnie Schneider, Eric M. Reiman,
... we first assessed hippocampal and callosal anatomy in PSAPP (PS1xAPP) mice, another transgenic mouse model of AD, ... used fluorodeoxyglucose (FDG) autoradiography in older and younger PSAPP and wildtype mice to assess the functional state ... found in these animals. Like patients with AD, PSAPP mice have age-related metabolic reductions in posterior ... progressive and preferential reductions in retrosplenial metabolism in PSAPP mice, these reductions could provide an indicator of ...
Tópico(s): Prion Diseases and Protein Misfolding
2006 - Elsevier BV | Brain Research
Samir Kumar‐Singh, Daniel Pirici, Eileen McGowan, Sally Serneels, C. Ceuterick, John Hardy, Karen Duff, Dennis W. Dickson, Christine Van Broeckhoven,
... the formation of these plaques. Using Tg2576 and PSAPP mouse models that exhibit age-related development of ... dense plaques in Tg2576 and approximately 85% in PSAPP mice are centered on vessel walls or in ... suggested that vascular associations for both Tg2576 and PSAPP mice were dramatically higher than those encountered by ... formation of vasocentric dense plaques in Tg2576 and PSAPP mouse models of AD.
Tópico(s): Neurological Disease Mechanisms and Treatments
2005 - Elsevier BV | American Journal Of Pathology
Hisatomo Kowa, Tomoko Sakakura, Yusuke Matsuura, Tomoko Wakabayashi, David M. A. Mann, Karen Duff, Shoji Tsuji, Tadafumi Hashimoto, Takeshi Iwatsubo,
... s disease (AD), Down syndrome (DS), and of PSAPP transgenic mice. In AD and DS cerebral cortex, ... CLAC burden remained at a constant level. In PSAPP transgenic mice, CLAC was positive in the diffuse ... s disease (AD), Down syndrome (DS), and of PSAPP transgenic mice. In AD and DS cerebral cortex, ... CLAC burden remained at a constant level. In PSAPP transgenic mice, CLAC was positive in the diffuse ... M671L mutant βAPP gene and M146L mutant PS1 (PSAPP mice17Holcomb L Gordon MN McGowan E Yu X ...
Tópico(s): Point processes and geometric inequalities
2004 - Elsevier BV | American Journal Of Pathology
Emilie L. Castranio, Philip Hasel, Jean‐Vianney Haure‐Mirande, Angie V. Ramirez Jimenez, B. Wade Hamilton, Rachel D. Kim, Charles Glabe, Minghui Wang, Bin Zhang, Sam Gandy, Shane A. Liddelow, Michelle E. Ehrlich,
... in microglia of APP KM670/671NL /PSEN1 Δexon9 (PSAPP) mice, we injected 3‐month‐old Inpp5d fl/fl /Cx3cr1 CreER/+ and PSAPP/Inpp5d fl/fl /Cx3cr1 CreER/+ mice with either ... results demonstrate that conditional Inpp5d downregulation in the PSAPP mouse increases plaque burden and recruitment of microglia ...
Tópico(s): Nuclear Receptors and Signaling
2022 - Wiley | Alzheimer s & Dementia
Joseph Ojo, Gogce Crynen, Jon M. Reed, Rosa Ajoy, Prashanthi Vallabhaneni, Moustafa Algamal, Paige Leary, Naomi G. Rafi, Benoit Mouzon, Michael Mullan, Fiona Crawford,
... AD, we used the well-validated hTau and PSAPP(APP/PS1) mouse models that develop age-related ... 9, and 15 months-old for hTau and PSAPP mice), encompassing pre-, peri- and post-“onset” of ... systems. We identified 18 proteins significantly changing in PSAPP mice and 19 proteins in hTau mice compared ... three models i.e. r-mTBI, hTau and PSAPP mice compared to their controls. The top canonical ...
Tópico(s): Mitochondrial Function and Pathology
2018 - Frontiers Media | Frontiers in Aging Neuroscience
Donna Darlington, Song Li, Huayan Hou, Ahsan Habib, Jun Tian, Yang Gao, Jared Ehrhart, Paul R. Sanberg, Darrell Sawmiller, Brian Giunta, T. Mori, Jun Tan,
... cognitive impairments and reduce Aβ-associated neuropathology in PSAPP transgenic mice. However, the mechanism for these effects ... AD-like pathology and associated cognitive impairments in PSAPP transgenic AD model mice. PSAPP mice and their wild-type littermates were treated ...
Tópico(s): Neurogenesis and neuroplasticity mechanisms
2015 - SAGE Publishing | Cell Transplantation
Lauriaselle Afanador, Emily Roltsch, Leigh A. Holcomb, Kerry S. Campbell, David A. Keeling, Yan Zhang, Danna B. Zimmer,
... Aβ) plaque deposition and Akt activity in the PSAPP AD mouse model. PSAPP/S100A1−/− mice exhibited decreases in astrocytosis (GFAP burden), ... burden) and plaque load/number when compared to PSAPP/S100A1+/+ mice at six and twelve months of ...
Tópico(s): Connexins and lens biology
2014 - Elsevier BV | Cell Calcium
Takashi Mori, Naoki Koyama, Tatsuya Segawa, Masahiro Maeda, Nobuhiro Maruyama, Noriaki Kinoshita, Huayan Hou, Jun Tan, Terrence Town,
... We orally administered MB to the aged transgenic PSAPP mouse model of cerebral amyloidosis and evaluated cognitive ... species, including oligomers, were mitigated in MB-treated PSAPP mice. These effects occurred with inhibition of amyloidogenic ... We orally administered MB to the aged transgenic PSAPP mouse model of cerebral amyloidosis and evaluated cognitive ... species, including oligomers, were mitigated in MB-treated PSAPP mice. These effects occurred with inhibition of amyloidogenic ...
Tópico(s): Amino Acid Enzymes and Metabolism
2014 - Elsevier BV | Journal of Biological Chemistry
Yuyan Zhu, Huayan Hou, Kavon Rezai‐Zadeh, Brian Giunta, Amanda Ruscin, Carmelina Gemma, Jingji Jin, Natasa Dragicevic, Patrick C. Bradshaw, Suhail Rasool, Charles Glabe, Jared Ehrhart, Paula C. Bickford, Takashi Mori, Demian Obregon, Terrence Town, Jun Tan,
... amyloid-β peptide (Aβ) but deficient in CD45 ( PSAPP/CD45 −/− mice) faithfully recapitulate AD neuropathology. Specifically, we ... α and interleukin-1β, and neuronal loss in PSAPP/CD45 −/− mice compared with CD45-sufficient PSAPP littermates (bearing mutant human amyloid precursor protein and ... mitochondrial dysfunction, and loss of cortical neurons in PSAPP/CD45 −/− mice. These data show that deficiency in ...
Tópico(s): S100 Proteins and Annexins
2011 - Society for Neuroscience | Journal of Neuroscience
Andreana C. Leskovjan, Antonio Lanzirotti, Lisa M. Miller,
... Cu, Fe, and Ca ion distribution in the PSAPP transgenic mouse model representing end-stage AD (N= ... normalizing to protein density, we found that the PSAPP plaques contained only a 29% increase in Zn ... toxic to neurons, the reduced metal binding in PSAPP mice is consistent with the lack of neurodegeneration ...
Tópico(s): Aluminum toxicity and tolerance in plants and animals
2009 - Elsevier BV | NeuroImage
Leigh A. Holcomb, Muralikrishnan Dhanasekaran, Angie R. Hitt, Keith A. Young, Mark W. Riggs, Bala V. Manyam,
PSAPP mice expressing the "Swedish" amyloid precursor protein and M146L presenilin-1 mutations are a well-characterized ... monniera extract (BME) on amyloid (Abeta) pathology in PSAPP mice, two doses of BME (40 or 160 ... and open field hyperlocomotion behavioral changes present in PSAPP mice. The areas encompassed by Congo Red-positive ...
Tópico(s): Cholinesterase and Neurodegenerative Diseases
2006 - IOS Press | Journal of Alzheimer s Disease
Joseph Ojo, Gogce Crynen, Moustafa Algamal, Prashanti Vallabhaneni, Paige Leary, Benoit Mouzon, Jon M. Reed, Michael Mullan, Fiona Crawford,
... KM670/671NL (Swedish) and Presenilin 1 M146L mutations [PSAPP]) and tauopathy (hTau). Brain tissues from animals were ... a lack of amyloid and tau pathology. In PSAPP mice, we identified 19 proteins significantly changing in ... overlap between our r-mTBI model and the PSAPP/hTau models, a fairly small coincidental change was ...
Tópico(s): S100 Proteins and Annexins
2020 - SAGE Publishing | ASN NEURO
Olga Prikhodko, Kevin D. Rynearson, Travis Sekhon, Mike Mante, Phuong D. Nguyen, Robert A. Rissman, Rudolph E. Tanzi, Steven L. Wagner,
... effective disease-modifying or preventative treatment in the PSAPP mouse model of AD. Methods:We treated pre- ... month-old) and post-plaque (6-month-old) PSAPP AD transgenic mice for 3 months and examined ... and astrogliosis associated with the AD phenotype of PSAPP mice when administered to pre-plaque (3-month- ...
Tópico(s): Dementia and Cognitive Impairment Research
2020 - IOS Press | Journal of Alzheimer s Disease
Takashi Mori, Naoki Koyama, Jun Tan, Tatsuya Segawa, Masahiro Maeda, Terrence Town,
... pathology in the presenilin-amyloid β-protein precursor (PSAPP) transgenic mouse model of cerebral amyloidosis. One-year- ... FA alone or in combination for 3 months. PSAPP mice receiving combination therapy had statistically significant improved ... in OG- plus FA-treated versus singly-treated PSAPP mice. These effects coincided with enhanced nonamyloidogenic amyloid ...
Tópico(s): Advanced Glycation End Products research
2017 - Elsevier BV | Journal of Biological Chemistry
Claudia Späni, Tobias Suter, Rebecca Derungs, Maria Teresa Ferretti, Tobias Welt, Fabian Wirth, Christoph Gericke, Roger M. Nitsch, Luka Kulic,
... the adaptive immune system in brain β-amyloidosis, PSAPP transgenic mice, an established mouse model of Alzheimer’ ... T cells. In a second experimental paradigm, aged PSAPP mice were reconstituted with bone marrow cells from ... and decreased brain amyloid β-peptide levels in PSAPP mice lacking functional adaptive immune cells. The decrease ...
Tópico(s): Tryptophan and brain disorders
2015 - Springer Science+Business Media | Acta Neuropathologica Communications
Muralikrishnan Dhanasekaran, Leigh A. Holcomb, Angie R. Hitt, Binu Tharakan, Jami W. Porter, Keith A. Young, Bala V. Manyam,
Abstract PSAPP mice expressing the ‘Swedish’ amyloid precursor protein and the M146L presenilin 1 mutations are a well‐characterized ... extract (CaE) can alter the amyloid pathology in PSAPP mice by administering CaE (2.5 or 5. ... altering amyloid β pathology in the brains of PSAPP mice and modulating components of the oxidative stress ...
Tópico(s): Cholinesterase and Neurodegenerative Diseases
2008 - Wiley | Phytotherapy Research
William V. Nikolic, Huayan Hou, Terrence Town, Yuyan Zhu, Brian Giunta, Cyndy D. Sanberg, Jin Zeng, Deyan Luo, Jared Ehrhart, Takashi Mori, Paul R. Sanberg, Jun Tan,
... alter AD-like pathology after infusion into the PSAPP mouse model of AD. Here, we report a ... Aβ levels. Moreover, microglia isolated from HUCBC-infused PSAPP mice demonstrated increased phagocytosis of Aβ. Furthermore, sera from HUCBC-infused PSAPP mice significantly increased microglial phagocytosis of the Aβ1- ...
Tópico(s): Advanced Glycation End Products research
2008 - Mary Ann Liebert, Inc. | Stem Cells and Development
Jaime Grutzendler, Kathryn A. Helmin, Julia Tsai, Wen-Biao Gan,
... in both a transgenic mouse model of AD (PSAPP) and in human postmortem brain. We found that in PSAPP mice, dendritic branches passing through or within 40 ... loss as the most common abnormality in both PSAPP mice and human AD brains. These results demonstrate ...
Tópico(s): Neuroscience and Neuropharmacology Research
2007 - Wiley | Annals of the New York Academy of Sciences
Eileen McGowan, Sunny Sanders, Takeshi Iwatsubo, Ayano Takeuchi, Takaomi C. Saido, Cindy Zehr, Xin Yu, Sacha N. Uljon, R. Wang, David M. A. Mann, Dennis W. Dickson, Karen Duff,
Doubly transgenic mice (PSAPP) overexpressing mutant APP and PS1 transgenes were examined using antibodies to Aβ subtypes and glial fibrillary acidic protein (GFAP). ... deposition began primarily in the cingulate cortex of PSAPP mice at approximately 10 weeks of age. By ... increased with age, but in 14-month-old PSAPP mice, GFAP immunoreactivity in the vicinity of amyloid ...
Tópico(s): Prion Diseases and Protein Misfolding
1999 - Elsevier BV | Neurobiology of Disease
Shanshan Wang, Taiga Ichinomiya, Yuki Terada, Dongsheng Wang, Hemal H. Patel, Brian P. Head,
... in the hippocampus of 9-month (m) old PSAPP mice, while hippocampal overexpression of neuron-targeted Cav- ...
Tópico(s): Alzheimer's disease research and treatments
2021 - Multidisciplinary Digital Publishing Institute | Cells
Megan W. Bourassa, Andreana C. Leskovjan, Ryan Tappero, Erik R. Farquhar, Carol A. Colton, William E. Van Nostrand, Lisa M. Miller,
... CVN) and one that shows very little neurodegeneration (PSAPP).The Fe, Cu, and Zn contents and speciation ... plaques contained ~25% more copper compared to the PSAPP mice. The iron content in the cortex increased ...
Tópico(s): Heavy Metal Exposure and Toxicity
2013 - IOS Press | Biomedical Spectroscopy and Imaging
T. Mori, Naoki Koyama, Marie‐Victoire Guillot‐Sestier, Jun Tan, Terrence Town,
... phenolic compound ferulic acid (FA) to the transgenic PSAPP mouse model of cerebral amyloidosis (bearing mutant human ... species including oligomers were decreased in FA-treated PSAPP mice. These effects occurred with decreased cleavage of ...
Tópico(s): Cholinesterase and Neurodegenerative Diseases
2013 - Public Library of Science | PLoS ONE
T. Mori, Kavon Rezai‐Zadeh, Naoki Koyama, Gary W. Arendash, Haruyasu Yamaguchi, Nobuto Kakuda, Yuko Horikoshi‐Sakuraba, Jun Tan, Terrence Town,
... the flavonoid tannic acid (TA) to the transgenic PSAPP mouse model of cerebral amyloidosis (bearing mutant human ... species including oligomers were mitigated in TA-treated PSAPP mice. These effects occurred with decreased cleavage of ...
Tópico(s): Protein Hydrolysis and Bioactive Peptides
2012 - Elsevier BV | Journal of Biological Chemistry
Andreana C. Leskovjan, Ariane Kretlow, Lisa M. Miller,
... in specific regions of the hippocampus in the PSAPP mouse model of AD as a function of ... 01) but remained low and relatively constant in PSAPP mice. Thus, these findings indicate that unsaturated lipid ...
Tópico(s): Computational Drug Discovery Methods
2010 - American Chemical Society | Analytical Chemistry
Yuyan Zhu, Demian Obregon, Huayan Hou, Brian Giunta, Jared Ehrhart, Frank Fernandez, Takashi Mori, William V. Nikolic, Yangbing Zhao, Dave Morgan, Terrence Town, Jun Tan,
... Tg2576 mice) or both mhAPP and mhPS1 genes (PSAPP mice) with allogeneic bone marrow cells. Here, we ... β-amyloid plaques and brain inflammatory responses in PSAPP mice following strain-matched wild-type PS1 bone ...
Tópico(s): Cholinesterase and Neurodegenerative Diseases
2009 - Wiley | Journal of Cellular and Molecular Medicine
William V. Nikolic, Yun Bai, Demian Obregon, Huayan Hou, T. Mori, Jin Zeng, Jared Ehrhart, R. Douglas Shytle, Brian Giunta, Dave Morgan, Terrence Town, Jun Tan,
... t.c. immunization in reducing cerebral amyloidosis, transgenic PSAPP (APPsw, PSEN1dE9) mice were immunized with aggregated Aβ ... 42 peptide plus CT. Similar to WT mice, PSAPP mice showed high Aβ antibody titers. Most importantly, ...
Tópico(s): Prion Diseases and Protein Misfolding
2007 - National Academy of Sciences | Proceedings of the National Academy of Sciences
Ghania Ait‐Ghezala, Claude‐Henry Volmar, Jeremy S. Frieling, Daniel Paris, Miles Tweed, Pancham Bakshi, Michael Mullan,
... CD40/CD40L interaction improves memory deficits in the PSAPP AD mouse model. We have also recently shown ... CD40 deficiency mitigates amyloid deposition in APPsw and PSAPP mouse models. In the present report, using human ...
Tópico(s): Drug Transport and Resistance Mechanisms
2007 - Wiley | European Journal of Neuroscience