George Cole, Anthony Harris, Raymond Snoddy Media Editor, Andrew Pierce, Julian Muscat, Tennis Correspondent, Chris Ward, Tim Nagley, Adrian Lee, Grace Bradberry, Kate Agius, Rob Hughes, Simon Barnes, Diana Wildman, Giles Whittell and Anjana Ahuja, Inigo Gilmore, Richard Hobson, John Diamond, Gavin Lumsden, Raymond Snoddy, Media Editor, James Landale, Political Reporter, Joan Llewelyn Owens, Philip Howard, Murray Naylor (Chairman), Janet Bush Economics Editor, Ian Murray, Michael Binyon, James Bone, Sheila Johnston, Lynne Truss, Peter Foster, Carl Mortished, Elisabeth Williamson, Tom Walker, Michael Fogarty, Raymond Snoddy, Clare Stewart, Robert Sheehan, Bridge Correspondent, Martin Fletcher, M. O'malley, Jill Sherman, Chief Political Correspondent, John O'leary Education Editor, Beverley Morgan, Dominic Walsh, Debra Craine, Julian Critchley, Raymond Keene Chess Correspondent, Nicholas Booth, Audrey Magee Ireland Correspondent, Ruth Gledhill Religion Correspondent, Martin Barrow, Stephen Farrell, Robin Young, Jenny MacArthur, Eve-Ann Prentice, Michael Berry, Charles Bremner, John Kavanagh, Helen Rumbelow, Charles Evans, Philip Bassett, Industrial Editor, Nigella Lawson, Ingram Lloyd, Rob Walters, Dewi Rees, Russell Kempson, Nigel Williamson, Daniel McGrory, Richard Cork, Paul Durman, Philip Bassett, Belinda Archer, Tony Hoare, John Hopkins Golf Correspondent, Adam Jones, Clive Parker, Mike Prestage, Raymond Keene, Polly Newton, John Russell Taylor, Matt Dickinson, A. A. C. Barnard, Frances Gibb, Legal Correspondent, P. H. S, Chris Partridge, CherylClifford, Nigel Hawkes, Lin Jenkins and Shirley English, Eric Reguly, Richard Owen, Susan Gray, Nicholas Watt and Philip Webster, Oliver August, Peter Bradley, Karen Buck, Andrew Dismore, J. H. McGivering, Philip Webster, Political Editor, Ian Brammer, Todd Longstaffe-Gowan (Editor), Oliver Holt, Football Correspondent, David Hands Rugby Correspondent, Sue Spenceley Burch, Nicholas Wood, Valerie Elliott, Whitehall Editor, Richard Duce, John Allison, Geof Wheelwright, John Lloyd, Jason Nisse, Christopher Walker, Jane Shilling, Simon De Bruxelles, Mel Webb, Annie Turner, Matthew Parris, Richard Evans Racing Correspondent, Gavin Hadland, Chris McGrath, Russell Jenkins, Simon Brooke, Peter Riddell, Ben MacIntyre, Ray Hatley, Michael Gove, Brian Glanville, Cato, Philip Webster, Simon Jenkins, John Ware (Reporter), Martin Waller, Elizabeth Cowley, Chris Ayres, Alan Coren, Benedict Nightingale, Nigel Powell, Tom Rhodes, Frances Gibb Legal Correspondent, Lindsay Nicolle, Michael Evans Defence Correspondent, Sam Kiley, David Maddock, Andy Zneimer, Marcia MacLeod, Michael Theodoulou, Michael Binyon and Daniel McGrory, Barry Phelps (Councillor), Kevin Eason, Motoring Editor, Alasdair Murray, Economics Correspondent, Jonathan Mirsky, Christopher Irvine, Arthur Leathley Transport Correspondent,
... Items High profile personal secretary Secretary/receptionist Ammirati Puris Lintas PA Vi John Associates Staples WA Janette ...
1997 - Gale Group | TDA
Er-xun Kang, Xing Gao, Yue-Ping Yin, Fu‐Sheng Wang, Weidong Yao, X Gong, Xiang‐Sheng Chen,
... lymphonode enlarged, light tenderness, biopsy found rare liquor puris in inguinal lymphonode. Vaginoscopy found 3.2 cm × ... with 6-well culture plate. To take liquor puris from lymphonode into a 5 ml centrifuge tube, ... lump on cervix. Biopsy found white rare liquor puris in the left inguinal lymph node. Microscopic examination ...
Tópico(s): Cervical Cancer and HPV Research
2007 - Lippincott Williams & Wilkins | Chinese Medical Journal
Widget Finn, Rosemary Righter, Jon Ashworth, Patricia Davies, Adrian Lee, Magnus Linklater, Sean O'Callaghan, Bernard Kaukas, Ronald Faux, Harvey Elliott, Jullian Muscat, Tennis Correspondent, Clive Fairweather, Philip Howard, James Bone and Joanna Bale, Lewin, Ian Murray, Jeremy Kingston, Lynne Truss, Peter Foster, Carl Mortished, Oliver Holt Football Correspondent, Gordon Beveridge, Vice-Chancellor, A. Butler, Stewart Tendler, Crime Correspondent, Tom Walker, Jonathan Mirsky, Geoff Brown, Robert Sheehan, Bridge Correspondent, Malcolm Bradbury, John Bryant, John Hopkins, Golf Correspondent, A. Stephen Melcher, Chief Executive, Dominic Walsh, Jim McCue, Carol Midgley, Media Correspondent, Raymond Keene Chess Correspondent, John Street, Michael Portillo, Ruth Gledhill Religion Correspondent, Matthew Parris Political Sketch, Nick Nuttall Technology Correspondent, Rodney Legg, Eric Sjogren, Stephen Farrell, Robin Young, Jill Sherman Chief Political Correspondent, Jenny MacArthur, Robert Bruce, Michael Clark, John O'Leary, Michael Pinto-Duschinsky, Kevin Eason Motoring Editor, Keith Pike, Martin Fletcher Chief Ireland Correspondent, Keith Douglas, Rachel Morris, Philip Bassett, Industrial Editor, Michael Binyon Diplomatic Editor, A. E. Norris, Roger Scruton, Russell Kempson, Daniel McGrory, Paul Durman, Carol Midgley Media Correspondent, Mike O'brien, Martin Fletcher, Chief Ireland Correspondent, Shirley English and Nicholas Watt, Marit Hargie, John Hopkins, Lin Jenkins, Daniel McGrory and Michael Theodoulou, John Grigsby, Nick Land, Adam Jones, Richard Ottaway, Raymond Keene, Polly Newton, Matt Dickinson, Alix Ramsay, Paul Wilkinson, P. H. S, David Graham, Vice-President, Nigel Hawkes, Jill Sherman, Eric Reguly, Michael Calvin, Nigel Hawkes, Science Editor, Oliver August, R. W. Johnson, John Allison, Christopher Thomas, William Rees-Mogg, John Goodbody, Nick Szczepanik, Iola Smith, Simon De Bruxelles, Jason Nissé, Mel Webb, Des Dearlove, Gerald Larner, Peter Ewart, Anjana Ahuja, Adrian Slade, President, Amanda Craig, Chris McGrath, Peter Riddell, Ben MacIntyre, Philip Prior, Brian Glanville, Alan Jenkins, Philip Webster, Brian Brivati, David Crawford, Graham Searjeant, David Sinclair, Tania Glyde, Mark Henderson, Martin Waller, Michael Horsnell, Benedict Nightingale, Alexandra Frean, Social Affairs Correspondent, Stuart Birch, Tom Rhodes, Dr Thomas Stuttaford, Frances Gibb Legal Correspondent, Sam Kiley, Susan MacDonald, Robin Lodge, David Maddock, Robert Whymant, David Hands, Rugby Correspondent, J. B. Pollock, Russell,
... of the Hong… Multiple Display Advertising Items Ammirati Puris Lintas Links of London Management/pa Multiple Classified ...
1997 - Gale Group | TDA
Produção Nacional
Revisado por pares
Larissa Anuska Zeni Condas, Márcio Garcia Ribeiro, Katsukiyo Yazawa, Águeda Castagna de Vargas, Tatiana Salerno, Rogério Giuffrida, Hélio Langoni, Priscila Anne Melville, Sônia Biesdorf, Tetsuhiro Matsuzawa, Tohru Gonoi, John P. Kastelic, Herman W. Barkema,
... species, followed by Nocardia farcinica (9%). Additionally, Nocardia puris, Nocardia cyriacigeorgica, Nocardia veterana, Nocardia africana, and Nocardia ... This is apparently the first report of N. puris, N. veterana, N. cyriacigeorgica, N. arthritidis and N. ...
Tópico(s): Mycobacterium research and diagnosis
2013 - Elsevier BV | Veterinary Microbiology
... in King Po., Der Maler Biard Bei Den Puris-Indianern in Brasilien, Der Goldreichthum in Britisch Columbia, ...
1862 - Gale Group | NCCO SciTechMed 2 of 2
Parimala Kancharla, M. L. Sudha,
... at 0.5% w/w level led to puris having improved quality characteristics to a greater extent ... moisture loss and oil uptake were lower in puris with guar gum than control.
Tópico(s): Biofuel production and bioconversion
2011 - Elsevier BV | Food Hydrocolloids
Montague Darling, V. Montanaro, H. L Anderson Secretary to the Government, J Davison, Mr Justice Byles, Mr Ernest Falkseer, Baron Von Humboldt,
... Court of Common PLEAS—Yesterday (Sittings at Nisi Puris, before Mr Justice Byles and a Common Jury) ...
1858 - Gale Group | Sunday Times HA GDA
Chih‐Cheng Lai, Wei‐Lun Liu, Wen‐Chien Ko, Yen‐Hsu Chen, Hon-Ren Tan, Yu‐Tsung Huang, Po‐Ren Hsueh,
... nova ( n = 8), N. asiatica ( n = 7), N. puris ( n = 6), N. flavorosea ( n = 5), N. abscessus ( ... N. beijingensis , N. otitidiscaviarum , N. nova , and N. puris and more than half of the N. brasiliensis ...
Tópico(s): Infectious Diseases and Mycology
2011 - American Society for Microbiology | Antimicrobial Agents and Chemotherapy
... make only a few brief extracts from the Puris journals which arrived in the usual. News in ...
1827 - Gale Group | TDA
Kayo Watanabe, Masaaki Shinagawa, Masaru Amishima, Soji Iida, Katsukiyo Yazawa, Akiko Kageyama, Akikazu Ando, Yuzuru Mikami,
... of Nocardia carnea, N. elegans, N. paucivorans, N. puris and N. takedensis. This is the first isolation ...
Tópico(s): Genomics and Phylogenetic Studies
2006 - | Nippon Ishinkin Gakkai Zasshi
A. F. Yassin, Bettina Sträubler, Peter Schümann, K. P. Schaal,
... the genus Nocardia, for which the name Nocardia puris (type strain IMMIB R-145(T)=DSM 44599( ...
Tópico(s): Phytoplasmas and Hemiptera pathogens
2003 - Microbiology Society | INTERNATIONAL JOURNAL OF SYSTEMATIC AND EVOLUTIONARY MICROBIOLOGY
Tony Eteläinen, M. Catarina Silva, Johanna Uhari‐Väänänen, Francesca De Lorenzo, Maria Jäntti, Hengjing Cui, Marta Chavero‐Pieres, Tommi Kilpeläinen, Christina Mechtler, Reinis Svarcbahs, Erin Seppälä, Juha R. Savinainen, Elena Puris, Gert Fricker, Mikko Gynther, Ulrika Julku, Henri J. Huttunen, Stephen J. Haggarty, Timo T. Myöhänen,
Tauopathies are neurodegenerative diseases that are characterized by accumulation of hyperphosphorylated tau protein, higher-order aggregates, and tau filaments. Protein phosphatase 2A (PP2A) is a major tau dephosphorylating phosphatase, and a decrease in its activity has been demonstrated in tauopathies, including Alzheimer's disease. Prolyl oligopeptidase is a serine protease that is associated with neurodegeneration, and its inhibition normalizes PP2A activity without toxicity under pathological ...
Tópico(s): Ubiquitin and proteasome pathways
2023 - American Association for the Advancement of Science | Science Translational Medicine
Elena Puris, Gert Fricker, Mikko Gynther,
Transporter-mediated drug resistance is a major obstacle in anticancer drug delivery and a key reason for cancer drug therapy failure. Membrane solute carrier (SLC) transporters play a crucial role in the cellular uptake of drugs. The expression and function of the SLC transporters can be down-regulated in cancer cells, which limits the uptake of drugs into the tumor cells, resulting in the inefficiency of the drug therapy. In this review, we summarize the current understanding of low-SLC-transporter- ...
Tópico(s): HIV/AIDS drug development and treatment
2023 - Multidisciplinary Digital Publishing Institute | Pharmaceutics
Elena Puris, Seppo Auriola, Sabrina Petralla, Robin Hartman, Mikko Gynther, Elizabeth C. M. de Lange, Gert Fricker,
There is growing evidence that membrane transporters expressed at the blood-brain barrier (BBB) and brain parenchymal cells play an important role in Alzheimer's disease (AD) development and progression. However, quantitative information about changes in transporter protein expression at neurovascular unit cells in AD is limited. Here, we studied the changes in the absolute protein expression of five ATP-binding cassette (ABC) and thirteen solute carrier (SLC) transporters in the isolated brain microvessels ...
Tópico(s): Amino Acid Enzymes and Metabolism
2022 - Elsevier BV | Neurobiology of Disease
Elena Puris, Štěpán Kouřil, Lukáš Najdekr, Seppo Auriola, Sanna Loppi, Paula Korhonen, Mireia Gómez‐Budia, Gert Fricker, Katja M. Kanninen, Tarja Malm, David Friedecký, Mikko Gynther,
Neuroinflammation is an important feature in the pathogenesis and progression of central nervous system (CNS) diseases including Alzheimer’s disease (AD). One of the widely used animal models of peripherally induced neuroinflammation and neurodegeneration is a lipopolysaccharide (LPS)-induced inflammation mouse model. An acute LPS administration has been widely used for investigation of inflammation-associated disease and testing inflammation-targeting drug candidates. In the present metabolomic, lipidomic ...
Tópico(s): Alzheimer's disease research and treatments
2022 - Elsevier BV | Neuroscience
Elena Puris, Gert Fricker, Mikko Gynther,
Abstract Limited drug delivery to the brain is one of the major reasons for high failure rates of central nervous system (CNS) drug candidates. The blood–brain barrier (BBB) with its tight junctions, membrane transporters, receptors and metabolizing enzymes is a main player in drug delivery to the brain, restricting the entrance of the drugs and other xenobiotics. Current knowledge about the uptake transporters expressed at the BBB and brain parenchymal cells has been used for delivery of CNS drugs ...
Tópico(s): Neuroscience and Neuropharmacology Research
2022 - Springer Science+Business Media | Pharmaceutical Research
Viktor Balzer, Pascal Poc, Elena Puris, Stefan F. Martin, Maryam Aliasgari, Seppo Auriola, Gert Fricker,
The blood-brain barrier (BBB) represents one of the biggest hurdles for CNS related drug delivery, preventing permeation of most molecules, and therefore poses a major challenge for researchers in finding effective treatments for CNS diseases. The low permeability of molecules through the BBB is linked on one hand to the extreme tightness by tight junction (TJ) formation limiting the paracellular transport, and on the other hand to the presence of ATP-driven efflux pumps which actively transport unwanted ...
Tópico(s): Trace Elements in Health
2022 - Elsevier BV | European Journal of Pharmaceutics and Biopharmaceutics
Anne Mahringer, Elena Puris, Gert Fricker,
The blood-brain barrier represents the major challenge for delivering drugs to the central nervous system (CNS). It separates the blood circulation from the brain tissue, thereby protecting the CNS and maintaining its ion homeostasis. Unfortunately, most drugs are not able to cross this barrier in vivo despite promising in vitro results. One approach to solve this problem is the delivery of drugs via surface modified nanocarrier systems. This review will give an overview on currently tested systems, ...
Tópico(s): Barrier Structure and Function Studies
2021 - Elsevier BV | Neurochemistry International
Ida Bagus Gde Wirawibawa, I Dewa Gede Agung Diasana Putra, Ngakan Ketut Acwin Dwijendra,
... traditional gate called kori agung among palaces called puris, especially the architectural form in palaces of Gianyar. ...
Tópico(s): Cultural and Artistic Studies
2021 - | Civil Engineering and Architecture
Elena Puris, Seppo Auriola, Paula Korhonen, Sanna Loppi, Katja M. Kanninen, Tarja Malm, Jari Koıstınaho, Mikko Gynther,
Alzheimer's disease (AD) is an incurable disease, with complex pathophysiology and a myriad of proteins involved in its development. In this study, we applied quantitative targeted absolute proteomic analysis for investigation of changes in potential AD drug targets, biomarkers, and transporters in cerebral cortices of lipopolysaccharide (LPS)-induced neuroinflammation mouse model, familial AD mice (APdE9) with and without LPS treatment as compared to age-matched wild type (WT) mice. The ABCB1, ABCG2 ...
Tópico(s): Cholesterol and Lipid Metabolism
2021 - Elsevier BV | Journal of Pharmaceutical Sciences
J. Cobo, Amilkar Puris, Pavel Novoa‐Hernández, Águeda Parra Jiménez, Jesús Moreno-León, David Benavides,
Teaching computer programming is a real challenge in the State University of Milagro (UNEMI), located in one of the least-developed zones in Ecuador, a non-WEIRD country (WEIRD stands for Western, Educated, Industrialized, Rich and Democratic). Despite the application of various learning strategies, the historical pass rate does not exceed 43%. To solve this problem, we have relied on visual programming languages, specifically Scratch. Scratch is an open source software to learn programming that has ...
Tópico(s): Educational Games and Gamification
2021 - Multidisciplinary Digital Publishing Institute | Electronics
Pichit Chuenban, Puris Sornsaruht, Paitoon Pimdee,
As one of the world's most valuable fish, Tuna can either be found in inexpensive tins on grocery store shelves or on high-end auction blocks destined for Japanese sashimi and sushi restaurants. Moreover, Thailand is reported to be the world's largest exporter of prepared or preserved tuna, which in 2019 contributed an estimated $2.5 billion to Thailand's exports. However, brand research is very limited for canned tuna, especially when it comes to product packaging cues, and how packaging affects ...
Tópico(s): Halal products and consumer behavior
2021 - Elsevier BV | Heliyon
Elena Puris, Mikko Gynther, Seppo Auriola, Kristiina M. Huttunen,
Abstract Our growing understanding of membrane transporters and their substrate specificity has opened a new avenue in the field of targeted drug delivery. The L-type amino acid transporter 1 (LAT1) has been one of the most extensively investigated transporters for delivering drugs across biological barriers. The transporter is predominantly expressed in cerebral cortex, blood-brain barrier, blood-retina barrier, testis, placenta, bone marrow and several types of cancer. Its physiological function ...
Tópico(s): Epigenetics and DNA Methylation
2020 - Springer Science+Business Media | Pharmaceutical Research
G. Hariharan, R. Karthikeyan, Gunasekaran Rameshkumar, Swasthikka Roshni Prithiviraj, Ram S. Ravindran, Sagnik Sen, Prajna Lalitha,
... otitidiscaviarum (n=3), Nocardia amikacinitolerans (n=2), Nocardia puris (n=2) and Nocardia higoensis (n=1).Conclusions. ...
Tópico(s): Ocular Infections and Treatments
2020 - Microbiology Society | Journal of Medical Microbiology
Elena Puris, Mikko Gynther, Elizabeth C. M. de Lange, Seppo Auriola, Margareta Hammarlund‐Udenaes, Kristiina M. Huttunen, Irena Loryan,
l-Type amino acid transporter 1 (LAT1), selectively expressed at the blood–brain barrier (BBB) and brain parenchymal cells, mediates brain delivery of drugs and prodrugs such as l-dopa and gabapentin. Although knowledge about BBB transport of LAT1-utilizing prodrugs is available, there is a lack of quantitative information about brain intracellular delivery and influence of prodrugs on the transporter's physiological state. We studied the LAT1-mediated intrabrain distribution of a recently developed ...
Tópico(s): Neuroscience and Neuropharmacology Research
2019 - American Chemical Society | Molecular Pharmaceutics
J. Cobo, Amilkar Puris, Pavel Novoa‐Hernández, José Á. Galindo, David Benavides,
Learning computer programming is a challenging process. Among the current approaches for overcoming this challenge, visual programming languages (VPLs), such as Scratch, have shown very promising results for beginners. Interestingly, some higher education institutions have started to use VPLs to introduce basic programming concepts, mainly in CS1 courses. However, an important issue regarding Scratchs usage in higher education environments is that students may feel unmotivated being confronted by ...
Tópico(s): Educational Games and Gamification
2019 - Institute of Electrical and Electronics Engineers | IEEE Transactions on Learning Technologies
Elena Puris, Mikko Gynther, Johanna Huttunen, Seppo Auriola, Kristiina M. Huttunen,
Tópico(s): Neuroscience and Neuropharmacology Research
2019 - Elsevier BV | European Journal of Pharmaceutical Sciences
Elena Puris, Markku Pasanen, Veli‐Pekka Ranta, Mikko Gynther, Aleksanteri Petsalo, Pirjo Käkelä, Ville Männistö, Jussi Pihlajamäki,
Abstract There is a lack of information about the changes in drug pharmacokinetics and cytochrome P450 (CYP) metabolism after bariatric surgery. Here, we investigated the effects of laparoscopic Roux‐en‐Y gastric bypass (LRYGB) surgery on pharmacokinetics of nine drugs given simultaneously which may reveal changes in the activities of the main CYPs. Eight obese subjects undergoing LRYGB received an oral cocktail containing nine drugs, substrates of various CYPs: melatonin (CYP1A2), nicotine (CYP2A6), ...
Tópico(s): Bariatric Surgery and Outcomes
2019 - Wiley | Basic & Clinical Pharmacology & Toxicology
Karel Diéguez‐Santana, Oscar Rivera-Borroto, Amilkar Puris, Hai Pham‐The, Huong Le‐Thi‐Thu, Bakhtiyor Rasulev, Gerardo M. Casañola‐Martín,
Abstract In this report are used two data sets involving the main antidiabetic enzyme targets α‐amylase and α‐glucosidase. The prediction of α‐amylase and α‐glucosidase inhibitory activity as antidiabetic is carried out using LDA and classification trees ( CT ). A large data set of 640 compounds for α‐amylase and 1546 compounds in the case of α‐glucosidase are selected to develop the tree model. In the case of CT ‐J48 have the better classification model performances for both targets with values above ...
Tópico(s): Computational Drug Discovery Methods
2019 - Wiley | Chemical Biology & Drug Design
Mikko Gynther, Elena Puris, Soile Peltokangas, Seppo Auriola, Katja M. Kanninen, Jari Koıstınaho, Kristiina M. Huttunen, Marika Ruponen, Kati‐Sisko Vellonen,
The study aim was to evaluate the effect of Alzheimer's disease (AD) and inflammatory insult on the function of L-type amino acid transporter 1 (Lat1) at the mouse blood-brain barrier (BBB) as well as Lat1 function and expression in mouse primary astrocytes.The Lat1 function and expression was determined in wildtype astrocytes with and without lipopolysaccharide (LPS)-induced inflammation and in LPS treated AD APP/PS1 transgenic astrocytes. The function of Lat1 at the BBB was evaluated in wildtype mice ...
Tópico(s): Drug Transport and Resistance Mechanisms
2018 - Springer Science+Business Media | Pharmaceutical Research