HAZARD, BURNE, and WARNERS, Stock Brokers. State Lottery Office, No.93. Royal Exchange.,
... 7 years old, master of any weight, and quic, Sales By Auction.. News: Heligoland Mail. Heligoland, March ...
1811 - Gale Group | TDA
Song Shi, Gerda Mitteregger-Kretzschmar, Armin Giese, Hans A. Kretzschmar,
... detected by real-time quaking-induced conversion (RT-QuIC). However, there is no efficient method to quantify the amount of PrP Sc by RT-QuIC. Results Here we introduce quantitative RT-QuIC (qRT-QuIC) to quantify with high accuracy minute amounts of ... be detected by immunoblot after PK treatment. qRT-QuIC is based upon the quantitative correlation between the ... start of the conversion reaction detected by RT-QuIC. By seeding known amounts of PrP 27-30 quantified by immunoblot into qRT-QuIC a standard calibration curve can be obtained. Based ...
Tópico(s): RNA regulation and disease
2013 - Springer Science+Business Media | Acta Neuropathologica Communications
Maria Cramm, Matthias Schmitz, André Karch, E Mitrová, Franziska Kühn, Bjoern O. Schroeder, Alex J. Raeber, Daniela Varges, Yong‐Sun Kim, Katsuya Satoh, Steven Collins, Inga Zerr,
Real-time quaking-induced conversion (RT-QuIC) allows the amplification of miniscule amounts of scrapie prion protein (PrP(Sc)). Recent studies applied the RT-QuIC methodology to cerebrospinal fluid (CSF) for diagnosing human ... of the reproducibility, validity and stability of RT-QuIC in this context, an indispensable step for establishment ... patients and 400 control patients using the RT-QuIC method under various conditions. In addition, "blinded" ring ... The multi-centre inter-laboratory reproducibility of RT-QuIC revealed a Fleiss' kappa value of 0.83 ( ...
Tópico(s): Prion Diseases and Protein Misfolding
2015 - Springer Science+Business Media | Molecular Neurobiology
Matilde Bongianni, Christina D. Orrú, Bradley R. Groveman, Luca Sacchetto, Michele Fiorini, Giovanni Tonoli, Giorgio Triva, Stefano Capaldi, Silvia Testi, Sérgio Ferrari, Annachiara Cagnin, Anna Ladogana, Anna Poleggi, Elisa Colaizzo, Dorina Tiple, Luana Vaianella, Santina Castriciano, Daniele Marchioni, Andrew G. Hughson, Daniele Imperiale, Tatiana Cattaruzza, Gian Maria Fabrizi, Maurizio Pocchiari, Salvatore Monaco, Byron Caughey, Gianluigi Zanusso,
... using the real-time quaking-induced conversion (RT-QuIC) seeding assay, which detects minute amounts of the ... early diagnosis of CJD by using the RT-QuIC assay on CSF samples, OM samples, or both. ... and OM samples were analyzed using conventional RT-QuIC. The CSF samples underwent further testing using improved RT-QuIC conditions. In addition, the diagnostic performance of a ... 1 to June 30, 2015.Correlations between RT-QuIC results and the final diagnosis of recruited patients. ... 61 patients with sporadic CJD had positive RT-QuIC findings using OM or CSF samples or both ...
Tópico(s): Prion Diseases and Protein Misfolding
2016 - American Medical Association | JAMA Neurology
M. Heather West Greenlee, Melissa Lind, Robyn Kokemuller, Najiba Mammadova, Naveen Kondru, Sireesha Manne, Jodi D. Smith, Anumantha G. Kanthasamy, Justin J. Greenlee,
... immunolabeling. Recombinant prion protein (rPrP) used in RT-QuIC assay was expressed and purified using standard protocol ... 100-kDa cutoff filters before subjecting to RT-QuIC assay. The quality of rPrP was confirmed by NMR and CD spectral analyses. The RT-QuIC assay was performed using previously published protocols from ... M.B. Caughey B. Rapid and sensitive RT-QuIC detection of human Creutzfeldt-Jakob disease using cerebrospinal ... Nalgene Nunc plate sealer and subjected to RT-QuIC assay. The plates were incubated at 42°C ...
Tópico(s): Neurological diseases and metabolism
2016 - Elsevier BV | American Journal Of Pathology
John G. Gray, Catherine Graham, Sandor Dudas, Eric Paxman, Ben Vuong, Stefanie Czub,
... S. Hughson A.G. Caughey B. New generation QuIC assays for prion seeding activity.Prion. 2012; 6: ... and real-time quaking induced conversion (real-time QuIC) assay both use recombinant PrPc as a conversion ... not always the case. ASA and real-time QuIC are fundamentally derived from earlier autocatalytic conversion studies ... S. Hughson A.G. Caughey B. New generation QuIC assays for prion seeding activity.Prion. 2012; 6: ... the ASA protocol led to the real-time QuIC assay, which had reduced spontaneous PrP conversion events ...
Tópico(s): Amyotrophic Lateral Sclerosis Research
2016 - Elsevier BV | Journal of Molecular Diagnostics
Jan Rüth, Ingmar Poese, Christoph Dietzel, Oliver Hohlfeld,
... to a major change by the introduction of QUIC. Initiated by Google in 2012, QUIC provides a reliable, connection-oriented low-latency and ... paper, we provide the first broad assessment of QUIC usage in the wild. We monitor the entire ... about 46% of the DNS namespace to detected QUIC-capable infrastructures. Our scans show that the number of QUIC-capable IPs has more than tripled since then ... We find around 161 K domains hosted on QUIC-enabled infrastructure, but only 15 K of them present valid certificates over QUIC. Second, we analyze one year of traffic traces ...
Tópico(s): Network Security and Intrusion Detection
2018 - Springer Science+Business Media | Lecture notes in computer science
Arash Molavi Kakhki, Samuel Jero, David Choffnes, Cristina Nita-Rotaru, Alan Mislove,
Google's Quick UDP Internet Connections (QUIC) protocol, which implements TCP-like properties at the application layer atop a UDP transport, is now used by the vast majority of ... of environ-merits. Further frustrating attempts to evaluate QUIC is the fact that the protocol is under ... need for alternative techniques for understanding and evaluating QUIC when compared with previous transport-layer protocols. First, ... us to conduct analysis across multiple versions of QUIC to understand how code changes impact protocol effectiveness. ...
Tópico(s): Mobile Agent-Based Network Management
2019 - Association for Computing Machinery | Communications of the ACM
Şevket Arısu, Ertan Yildiz, Ali C. Begen,
Summary Quick User Datagram Protocol (UDP) Internet Connections (QUIC) is an experimental and low‐latency transport protocol ... applications may be improved with the help of QUIC's low‐latency, improved congestion control, and multiplexing features. We measured the streaming performance of QUIC on wireless and cellular networks in order to ... TCP can be reduced by using HTTP over QUIC. The performance of QUIC was tested in the presence of network interface ... the mobility of the viewer. We observed that QUIC resulted in quicker start of media streams, better ...
Tópico(s): Caching and Content Delivery
2019 - Wiley | International Journal of Network Management
Daniel D. Rhoads, Aleksandra Wrona, Aaron Foutz, Janis Blevins, Kathleen Glisic, Marissa K. Person, Ryan A. Maddox, Ermias D. Belay, Lawrence B. Schonberger, Curtis Tatsuoka, Mark L. Cohen, Brian S. Appleby,
... using CSF real-time quaking-induced conversion (RT-QuIC) as a diagnostic test, to examine factors associated with false-negative RT-QuIC results, and to investigate the impact of RT-QuICs on prion disease surveillance.Between May 2015 and ... time variables were examined for association with RT-QuIC results. The effect of including positive RT-QuIC cases in prion disease surveillance was examined.The diagnostic sensitivity and specificity of RT-QuIC across all prion diseases were 90.3% and ... disease. Individuals with prion disease and negative RT-QuIC results were younger and had lower tau levels ...
Tópico(s): Prion Diseases and Protein Misfolding
2020 - Lippincott Williams & Wilkins | Neurology
Carmen Peña‐Bautista, Rakesh Kumar, Miguel Baquero, Jan Johansson, Consuelo Cháfer‐Pericás, Axel Abelein, Daniel Ferreira,
... synuclein (α-syn). Realtime quaking induced conversion (RT-QuIC) has recently emerged as a strong biomarker candidate ... of-the-art research of α-syn RT-QuIC in DLB focused on: (1) the capacity of α-syn RT-QuIC to discriminate DLB from controls, Parkinson’s disease ( ... AD; (2) the capacity of α-syn RT-QuIC to identify prodromal stages of DLB; and (3) ... influence of co-pathologies on α-syn RT-QuIC’s performance. We also assessed the influence of ... publication dates. Search terms were combinations of “RT-QuIC” and “Lewy Bodies,” “DLB” or “LBD”. Results: Our ...
Tópico(s): Ginkgo biloba and Cashew Applications
2023 - Frontiers Media | Frontiers in Molecular Biosciences
Tanya Shreedhar, Rohit Panda, Sergey Podanev, Vaibhav Bajpai,
QUIC was launched in 2013 with a goal to provide reliable, connection-oriented and end-to-end ... Internet Engineering Task Force (IETF). This work evaluates QUIC performance over the web, cloud storage, and video ... TCP. To this end, we have designed tests ( quic_perf , tls_perf and video ) and conducted measurements ... workloads and probe them towards the support for QUIC, TLS 1.2 and TLS 1.3. By measuring $\lt 5.7$ K websites that support QUIC, we observe that QUIC has up to $\approx 140$ % lower mean connection ... high-RTT networks. When comparing different versions of QUIC, we observe that IETF QUIC connection times are ...
Tópico(s): Network Traffic and Congestion Control
2021 - Institute of Electrical and Electronics Engineers | IEEE Transactions on Network and Service Management
... PMCA) and real-time quaking-induced conversion (RT-QuIC) assays. The RT-QuIC technique was first developed to detect abnormally folded ... Candelise N Baiardi S et al. Ultrasensitive RT-QuIC assay with high sensitivity and specificity for Lewy ... of dementia with Lewy body patients in RT-QuIC. Mol Neurobiol. 2018; 55: 3916-3930 PubMed Google ... A Capaldi S et al. α-Synuclein RT-QuIC assay in cerebrospinal fluid of patients with dementia ... Detection of α-synuclein in CSF by RT-QuIC in patients with isolated rapid-eye-movement sleep ...
Tópico(s): Alzheimer's disease research and treatments
2021 - Elsevier BV | The Lancet Neurology
Ilaria Poggiolini, Vandana Ayyar Gupta, Michael Lawton, Selene Seoyun Lee, Aadil El-Turabi, Agustín Querejeta, Claudia Trenkwalder, Friederike Sixel‐Döring, Alexandra Foubert‐Samier, Anne Pavy‐Le Traon, Giuseppe Plazzi, Francesco Biscarini, Jacques Montplaisir, Jean‐François Gagnon, Ronald B. Postuma, Elena Antelmi, Wassilios G. Meissner, Brit Mollenhauer, Yoav Ben‐Shlomo, Joshua Shulman, Laura Parkkinen,
... α-synuclein real-time quaking-induced conversion (RT-QuIC) assay to have high sensitivity and specificity for ... the diagnostic value of CSF α-synuclein RT-QuIC quantitative parameters in regard to disease progression, stratification ... conversion in synucleinopathies. We performed α-synuclein RT-QuIC in the CSF samples from 74 Parkinson's ... in relation to clinical data. α-Synuclein RT-QuIC showed 89% sensitivity and 96% specificity for Parkinson's disease. There was no correlation between RT-QuIC quantitative parameters and Parkinson's disease clinical scores ( ...
Tópico(s): Botulinum Toxin and Related Neurological Disorders
2021 - Oxford University Press | Brain
Giorgio Vivacqua, Matthew Mason, Maria Ilenia De Bartolo, Michał Węgrzynowicz, Laura Calò, Daniele Belvisi, Antonio Suppa, Giovanni Fabbrini, Alfredo Berardelli, M. G. Spillantini,
... have used real-time quaking induced conversion (RT-QuIC) or protein misfolding cyclic amplification (PMCA) to detect ... PD patients.8, 9 We have applied RT-QuIC to a cohort of 37 de novo PD ... greater seeding-capacity in the a-syn RT-QuIC assay compared to salivary samples from HS (Fig. ... the fluorescence threshold and were, therefore, deemed RT-QuIC positive, with the remaining 6 (14%) being RT-QuIC negative. Among the 23 HS samples, 5 (22%) were deemed RT-QuIC positive and the remaining 18 (78%) RT-QuIC negative. The average lag-phase was significantly shorter ...
Tópico(s): Neurological diseases and metabolism
2022 - Wiley | Movement Disorders
Natasha G. Lindert, Megan Y. Maxwell, Sabrina R. Liu, Hal S. Stern, Tallie Z. Baram, Elysia Poggi Davis, Victoria B. Risbrough, Dewleen G. Baker, Caroline M. Nievergelt, Laura M. Glynn,
... therefore vital. The Questionnaire of Unpredictability in Childhood (QUIC) is a 38-item tool that measures unpredictability ... that exposure to unpredictable experiences measured with the QUIC predicts internalizing symptoms including depression and anxiety. The ... was to validate English and Spanish brief versions (QUIC-5) suitable for administration in time-limited settings ( ... studies). Five representative items were identified from the QUIC and their psychometric properties examined. The predictive validity ...
Tópico(s): Early Childhood Education and Development
2022 - Frontiers Media | Frontiers in Psychology
Michael Jefford, Linda Mileshkin, H. Raunow, Cecilia M. O’Kane, T. Cavicchiolo, H. Brasier, Martin Robinson, Jane Matthews, John Reynolds,
... age ≥ 18 years. Instruments assessed quality of IC (QuIC), QOL (EORTC QLQ C-30), anxiety and depression ( ... phase I/II/III - 6/10/11. Median QuIC objective knowledge score (QuIC-A) was 77.5 (/100) and perceived (subjective) understanding (QuIC-B) 91.4. Some questions were consistently answered poorly. There was low but significant correlation between QuIC-A and B (R=0.28, p=0.004). SWD was high. Correlation between QuIC-B and SWD was moderate (0.423, p<0.001). Correlations between SWD and each of QuIC-A, anxiety (HADS-A) and depression (HADS-D) ...
Tópico(s): Health Systems, Economic Evaluations, Quality of Life
2005 - Lippincott Williams & Wilkins | Journal of Clinical Oncology
Kazunori Sano, Katsuya Satoh, Ryuichiro Atarashi, Hiroshi Takashima, Yasushi Iwasaki, Mari Yoshida, Nobuo Sanjo, Hiroyuki Murai, Hidehiro Mizusawa, Matthias Schmitz, Inga Zerr, Yong-Sun Kim, Noriyuki Nishida,
... technology, designated "real-time quaking-induced conversion (RT-QUIC)", to detect the abnormal form of prion protein ... investigate the presence of biomarkers and evaluate RT-QUIC assay in patients with gPrD, as the utility of RT-QUIC as a diagnostic tool in gPrD has yet ... mutation. We subjected all CSF samples to RT-QUIC assay, analyzed 14-3-3 protein by Western ... an ELISA kit. The detection sensitivities of RT-QUIC were as follows: GSS (78%), FFI (100%), gCJD ... E200K (73%), and gCJD V203I (67%). Thus, RT-QUIC had a much higher detection sensitivity compared with ...
Tópico(s): Prion Diseases and Protein Misfolding
2013 - Public Library of Science | PLoS ONE
Christina D. Orrú, Andrew G. Hughson, Bradley R. Groveman, Katrina J. Campbell, Kelsie J. Anson, Matteo Manca, Allison Kraus, Byron Caughey,
... diseases. The real-time quaking-induced conversion (RT-QuIC) assay for prion seeding activity has been applied ... for specific antemortem diagnostic testing. We evaluated RT-QuIC's long-term consistency and varied multiple reaction ... two. Raising temperatures or shaking speeds accelerated RT-QuIC reactions without compromising specificity. When applied to nasal ... Creutzfeldt-Jakob disease patients, higher temperatures accelerated RT-QuIC kinetics, and the use of hamster rPrP(Sen) (90-231) strengthened RT-QuIC responses. Elongation of shaking periods reduced scrapie-seeded ...
Tópico(s): Prion Diseases and Protein Misfolding
2016 - Multidisciplinary Digital Publishing Institute | Viruses
Jawad Manzoor, Llorenç Cerdà‐Alabern, Ramin Sadre, Idílio Drago,
... speed up Internet applications have naturally emerged. The QUIC transport protocol is one prominent case. Initially developed ... in Google’s servers and Chrome browser. Since QUIC is still a relatively new protocol, there is ... present a comprehensive study on the performance of QUIC in Wireless Mesh Networks (WMN). We perform a ... a production WMN to compare the performance of QUIC against TCP when retrieving files from the Internet. Our results show that while QUIC outperforms TCP in wired networks, it exhibits significantly ...
Tópico(s): Caching and Content Delivery
2020 - Springer Science+Business Media | Journal of Network and Systems Management
Kang Xiao, Qi Shi, Wei Zhou, Xiao‐Ping Dong,
... the positive reactions of cerebrospinal fluid (CSF) RT-QuIC of FFI patients were markedly low. However, the reactivities of RT-QuIC of the brain tissues, particularly different brain regions, ... patients were subjected into two kinds of RT-QuIC assays using recombinant hamster PrP23-231 (rHaPrP23-231) ... respectively. The results showed that the general RT-QuIC reactivities of the brains from FFI cases were ... reactivities (lag time and rfu peak) of RT-QuIC identified that the homogenates of frontal lobe induced ...
Tópico(s): Alcoholism and Thiamine Deficiency
2020 - Landes Bioscience | Prion
Jean-Pierre Smith, Prateek Mittal, Adrian Perrig,
Abstract With the meteoric rise of the QUIC protocol, the supremacy of TCP as the de facto transport protocol underlying web traffic will soon cease. HTTP/3, the next version of ... classifiers trained in the TCP setting generalise to QUIC traces, whether QUIC is inherently more difficult to fingerprint than TCP, ... between these protocols, and how to jointly classify QUIC and TCP traces. Experiments using four state-of-theart website-fingerprinting classifiers and our combined QUIC-TCP dataset of ~117,000 traces show that ...
Tópico(s): Advanced Malware Detection Techniques
2021 - De Gruyter Open | Proceedings on Privacy Enhancing Technologies
Kang Xiao, Xuehua Yang, Wei Zhou, Cao Chen, Qi Shi, Xiao‐Ping Dong,
... development of real-time quaking-induced conversion (RT-QuIC) of cerebrospinal fluid (CSF) samples makes it possible ... sCJD. To test the diagnostic potential of RT-QuIC of skin specimens for probable sCJD, we collected ... disease (gPrD). The samples were subjected to RT-QuIC assays using recombinant hamster PrP protein rHaPrP90-231 as the substrate. Using skin RT-QuIC assay, 91.2% (31/34) probable sCJD patients, ... 14) non-CJD patients were negative. CSF RT-QuIC positive seeding activity was only observed in 14 ...
Tópico(s): Prion Diseases and Protein Misfolding
2021 - Multidisciplinary Digital Publishing Institute | Pathogens
Connor Bargar, Chiara Maria Giulia De Luca, Grazia Devigili, Antonio Emanuele Elia, Roberto Cilia, Sara Maria Portaleone, Wen Wang, Irene Tramacere, Edoardo Bistaffa, Federico Angelo Cazzaniga, Giovanni Felisati, Giuseppe Legname, Alessio Di Fonzo, Rong Xu, Steven A. Gunzler, Giorgio Giaccone, Roberto Eleopra, Shu Guang Chen, Fabio Moda,
... synuclein Real-Time Quaking-Induced Conversion (αSyn_RT-QuIC) analysis of OM samples collected from PD and ... 11). Each sample was analyzed by αSyn_RT-QuIC in two independent specialized laboratories, one located in ... laboratories have developed and used harmonized αSyn_RT-QuIC analytical procedures. Results were correlated with demographic and clinical data.The αSyn_RT-QuIC analysis reached a 96% interrater agreement of results ( ... 0.83-1.00). In particular, αSyn_RT-QuIC seeding activity was found in the OM of ...
Tópico(s): Animal testing and alternatives
2021 - BioMed Central | Molecular Neurodegeneration
Sara Hall, Christina D. Orrú, Geidy E. Serrano, Douglas Galasko, Andrew G. Hughson, Bradley R. Groveman, Charles H. Adler, Thomas G. Beach, Byron Caughey, Oskar Hansson,
... Lewy body disorders (LBD). α-synuclein (αSyn) RT-QuIC has emerged as a promising assay to detect ... with various synucleinopathies. In this study, αSyn RT-QuIC was used to analyze lumbar CSF in a ... and controls. In the BioFINDER cohort αSyn RT-QuIC identified LBD (i.e. PD, PDD and converters) ... controls that converted to LBD were αSyn RT-QuIC positive. Within the AZSAND/BBDP cohort, αSyn RT-QuIC identified neuropathologically verified "standard LBD" (i.e. PD, ... and specificity (94%). Only 57% were αSyn RT-QuIC positive in the subgroup with "non-standard" LBD ( ...
Tópico(s): Ginkgo biloba and Cashew Applications
2022 - Springer Science+Business Media | Acta Neuropathologica Communications
Peter R. Christenson, Manci Li, Gage R. Rowden, Marc D. Schwabenlander, Tiffany M. Wolf, Sang‐Hyun Oh, Peter A. Larsen,
... targets. In parallel, recently developed quaking-induced conversion (QuIC) assays leverage protein-amplification and fluorescent signaling for ... of misfolded proteins. Here, we combine AuNP and QuIC technologies for the visual detection of amplified misfolded ... disease of cervids. Our newly developed assay, MN-QuIC, enables both naked-eye and light-absorbance measurements for detection of misfolded prions. MN-QuIC leverages basic laboratory equipment that is cost-effective ... CWD on site. We successfully demonstrated that MN-QuIC is functional in a non-traditional laboratory setting ...
Tópico(s): Prion Diseases and Protein Misfolding
2022 - Nature Portfolio | Scientific Reports
Carine Lidiane Holz, Joseph R. Darish, Kelly Straka, Nicole L. Grosjean, Steven R. Bolin, Matti Kiupel, Srinand Sreevatsan,
... immunohistochemistry (IHC). Real-time quaking-induced conversion (RT-QuIC) assay is a newer approach that amplifies misfolded ... was undertaken to compare ELISA, IHC, and RT-QuIC on RLNs (n = 1,300 animals) from white- ... calculated by sex and age. ELISA and RT-QuIC detected PrPCWD in 184 and 178 out of ... discordant results when comparing IHC and ELISA. RT-QuIC revealed that six of the seven samples matched ... by IHC, but positive by ELISA and RT-QuIC. RT-QuIC, IHC, and ELISA also detected PrPCWD in prescapular, ...
Tópico(s): Animal Disease Management and Epidemiology
2022 - Frontiers Media | Frontiers in Veterinary Science
Steven Joffe, E. Francis Cook, Paul D. Cleary, Jeffrey W. Clark, Jane C. Weeks,
... a brief questionnaire, the Quality of Informed Consent (QuIC), to measure subjects' actual (objective) and perceived (subjective) understanding of cancer clinical trials. The QuIC incorporates the basic elements of informed consent specified ... template for informed consent documents. We modified the QuIC after receiving feedback from pilot tests with cancer ... two independent expert panels. We then sent the QuIC to 287 adult cancer patients enrolled on phase ... trials. Two hundred seven subjects (72%) completed the QuIC. To assess test–retest reliability, a random sample ...
Tópico(s): Patient-Provider Communication in Healthcare
2001 - Oxford University Press | JNCI Journal of the National Cancer Institute
Christina D. Orrú, Bradley R. Groveman, Andrew G. Hughson, Gianluigi Zanusso, Michael B. Coulthart, Byron Caughey,
... transmission risks. Real-time quaking-induced conversion (RT-QuIC) assays of cerebrospinal fluid (CSF) and nasal-brushing ... 5 to 5 days. Here, an improved RT-QuIC assay is described which identified positive CSF samples ... CJD patients demonstrated that while 7 were RT-QuIC positive using the previous conditions, 10 were positive ... sensitivity and 100% specificity. This second-generation RT-QuIC assay markedly improved the speed and sensitivity of ... unusually resistant to decontamination. The recently developed RT-QuIC test allows for highly sensitive and specific detection ...
Tópico(s): Prion Diseases and Protein Misfolding
2015 - American Society for Microbiology | mBio
Rohana P. Dassanayake, Christina D. Orrú, Andrew G. Hughson, Byron Caughey, Telmo Graça, Dongyue Zhuang, Sally A. Madsen‐Bouterse, Donald P. Knowles, David A. Schneider,
Real-time quaking-induced conversion (RT-QuIC) is a rapid, specific and highly sensitive prion seeding activity detection assay that uses recombinant prion protein (rPrPSen) to detect subinfectious levels ... isoforms of the prion protein (PrPSc). Although RT-QuIC has been successfully used to detect PrPSc in ... brain tissues of goats with scrapie using RT-QuIC, (2) optimize reaction conditions to improve scrapie detection ... goats, and (3) compare the performance of RT-QuIC for the detection of PrPSc with the more ...
Tópico(s): Trace Elements in Health
2015 - Microbiology Society | Journal of General Virology