Yi-Chien Lin, Jing-Wen Shih, Chia-Ling Hsu, Jing‐Jer Lin,
... we have shown that Cdc13p also binds DNA quadruplex, G-quartet, formed by TG1–3 DNA. Moreover, the ... we have shown that Cdc13p also binds DNA quadruplex, G-quartet, formed by TG1–3 DNA. Moreover, the ...
Tópico(s): Genomics and Chromatin Dynamics
2001 - Elsevier BV | Journal of Biological Chemistry
Martin H. Schludi, Dieter Edbauer,
... al (2018) describe novel compounds targeting the G-quadruplex (G-Q) structure of the (GGGGCC)n repeat RNA ... repeat RNA can form both so-called G-quadruplexes (G-Qs) and hairpins. G-Qs are four-stranded ...
Tópico(s): RNA Interference and Gene Delivery
2017 - Springer Nature | EMBO Molecular Medicine
Miguel Méndez, Veronika A. Szalai,
... unmodified oligonucleotides has not been exploited for guanine-quadruplex (G-quadruplex) characterization. We observe that G-rich sequences ...
Tópico(s): RNA Interference and Gene Delivery
2009 - Wiley | Biopolymers
Marco Di Antonio, Filippo Doria, Sara N. Richter, Carolina Bertipaglia, Mariella Mella, Claudia Sissi, Manlio Palumbo, Mauro Freccero,
We have developed novel G-quadruplex (G-4) ligand/alkylating hybrid structures, tethering the naphthalene diimide moiety to quaternary ammonium salts of Mannich bases, as quinone-methide precursors, ...
Tópico(s): RNA Interference and Gene Delivery
2009 - American Chemical Society | Journal of the American Chemical Society
Eva Fadrná, Nad’a Špačková, Joanna Sarzyńska, Jaroslav Koča, Modesto Orozco, Thomas E. Cheatham, Tadeusz Kuliński, Jiřı́ Šponer,
... solvent molecular dynamics (MD) simulations on two DNA quadruplex (G-DNA) molecules, namely the antiparallel d(G4T4G4)2 ...
Tópico(s): RNA and protein synthesis mechanisms
2009 - American Chemical Society | Journal of Chemical Theory and Computation
Barbara Gatto, Manlio Palumbo, Claudia Sissi,
... for unrelated targets. Among several architectures, the G-quadruplex (G-4) is adopted by several aptamers, the most ...
Tópico(s): RNA Interference and Gene Delivery
2009 - Bentham Science Publishers | Current Medicinal Chemistry
Xiaodong Shi, Katherine M. Mullaugh, James C. Fettinger, Yun Jiang, Steven A. Hofstadler, Jeffery T. Davis,
... observed even 2 months after the separate G-quadruplexes (G 1)16·2Ba2+·4(3) and (G 1) ...
Tópico(s): Supramolecular Chemistry and Complexes
2003 - American Chemical Society | Journal of the American Chemical Society
Richard Štefl, Thomas E. Cheatham, Nad’a Špačková, Eva Fadrná, Imre Berger, Jaroslav Koča, Jiřı́ Šponer,
The formation of a cation-stabilized guanine quadruplex (G-DNA) stem is an exceptionally slow process involving complex kinetics that has not yet been characterized at atomic resolution. Here, we investigate the ...
Tópico(s): RNA Interference and Gene Delivery
2003 - Elsevier BV | Biophysical Journal
Guanine quadruplex (G‐quadruplex) structures are formed by guanine‐rich oligonucleotides. Because of their in vivo and in vitro importance, ...
Tópico(s): RNA Interference and Gene Delivery
2003 - Oxford University Press | Nucleic Acids Research
Jia‐Heng Tan, Lian‐Quan Gu, Jian‐Yong Wu,
... major design strategies and structural characteristics. Keywords: G-quadruplex, G-quartet, ligands, substituted derivatives, affinity and selectivity, DNA ...
Tópico(s): Advanced biosensing and bioanalysis techniques
2008 - Bentham Science Publishers | Mini-Reviews in Medicinal Chemistry
Phong Lan Thao Tran, Jean‐Louis Mergny, Patrizia Alberti,
... repeats (found in ciliates) folded into stable G-quadruplexes, G-quadruplexes formed by repetitions of G 2 T ...
Tópico(s): Plant Virus Research Studies
2010 - Oxford University Press | Nucleic Acids Research
Sebastian König, Amanda C. Evans, J Huppert,
... no less biologically relevant, such as the G-quadruplex. G-quadruplexes continue to be the subject of a ...
Tópico(s): RNA Interference and Gene Delivery
2010 - De Gruyter | BioMolecular Concepts
Sara Bianco, Caterina Musetti, Andrew R. Waldeck, Silvia Sparapani, Joshua D. Seitz, A. Paul Krapcho, Manlio Palumbo, Claudia Sissi,
... focused on the recognition of physiologically relevant G-quadruplex (G-4) structures by bis-phenanthroline (bis-Phen) ligands ...
Tópico(s): RNA Interference and Gene Delivery
2010 - Royal Society of Chemistry | Dalton Transactions
... and limitations of modeling methods available for guanine quadruplex (G-DNA) molecules. We characterize the relations of simulations ...
Tópico(s): RNA Interference and Gene Delivery
2007 - Elsevier BV | Methods
Dipankar Sen, Lester Chi-Heng Poon,
... chromosomal telomeres and elsewhere that fold into guanine quadruplexes (G-quadruplexes), are found to complex tightly with porphyrins ...
Tópico(s): RNA and protein synthesis mechanisms
2011 - Taylor & Francis | Critical Reviews in Biochemistry and Molecular Biology
Jiřı́ Šponer, Xiaohui Cang, Thomas E. Cheatham,
... on explicit solvent molecular dynamics simulations of guanine quadruplex (G-DNA and G-RNA) molecules. While primarily dealing ...
Tópico(s): RNA and protein synthesis mechanisms
2012 - Elsevier BV | Methods
Anthony Bugaut, Pierre Murat, Shankar Balasubramanian,
... as the four-stranded structures known as G-quadruplexes. G-quadruplexes in the transcriptome have recently emerged as ...
Tópico(s): Advanced biosensing and bioanalysis techniques
2012 - American Chemical Society | Journal of the American Chemical Society
Huy T. Le, Robert Buscaglia, William L. Dean, Jonathan B. Chaires, John O. Trent,
... unique quadruple helical tertiary structures known as G-quadruplexes. G-quadruplexes have emerged as attractive drug targets as ...
Tópico(s): RNA and protein synthesis mechanisms
2012 - Springer Science+Business Media | Topics in current chemistry
Tani Agarwal, Gopal Gunanathan Jayaraj, Satyaprakash Pandey, Prachi Agarwala, Souvik Maiti,
G-quadruplexes are non canonical secondary structures held together by Hoogsteen bonded planar guanine quartets formed in G-rich sequences in DNA and RNA. Considerable research over the past three decades has contributed to a great deal of understanding of these unusual structures in DNA. Various factors governing the stability of DNA quadruplexes coupled with their in vivo existence have been well documented. RNA has emerged as a key regulatory player in the functioning of the cell shifting the ...
Tópico(s): DNA and Nucleic Acid Chemistry
2012 - Bentham Science Publishers | Current Pharmaceutical Design
Akash Jain, Santanu Bhattacharya,
... binder-G4-DNA interactions. Keywords: Telomere, telomerase, G-quadruplex, G-quadruplex ligands, groove binding ligands, i-motif, chromosomes, ...
Tópico(s): Molecular Junctions and Nanostructures
2012 - Bentham Science Publishers | Current Pharmaceutical Design
Pietro Fratta, Sarah Mizielinska, Andrew J. Nicoll, Mire Zloh, Elizabeth Fisher, Gary N. Parkinson, Adrian M. Isaacs,
... structures in both RNA and DNA termed G-quadruplexes. G-quadruplexes have been shown to be involved in ...
Tópico(s): Amyotrophic Lateral Sclerosis Research
2012 - Nature Portfolio | Scientific Reports
Rubén Ferreira, Margarita Alvira, Anna Aviñó, Irene Gómez‐Pinto, Carlos González, Valérie Gabelica, Ramón Eritja,
... noncanonical four‐stranded structure known as the G‐quadruplex. G‐quadruplex structures are interesting because of their potential ...
Tópico(s): RNA Interference and Gene Delivery
2012 - WileyOpen | ChemistryOpen
Qian Li, Junfeng Xiang, Qianfan Yang, Hongxia Sun, Aijiao Guan, Yalin Tang,
... ligands to streamline ligand/drug discovery targeting G-quadruplexes. G-quadruplexes are guanine-rich nucleic acid sequences in ...
Tópico(s): RNA Interference and Gene Delivery
2012 - Oxford University Press | Nucleic Acids Research
Yusuke Ishihara, Shunsaku Kimura,
... peptide‐nanotube bundle with the formation of guanine quadruplex (G‐quartet). CPG was so soluble in water that ...
Tópico(s): Advanced biosensing and bioanalysis techniques
2012 - Wiley | Biopolymers
Anh Tuân Phan, Vitaly Kuryavyi, Hai Yan Gaw, Dinshaw J. Patel,
... helix. One recent important example is the guanine-quadruplex (G-quadruplex) structure formed by guanine tracts found in ...
Tópico(s): RNA Interference and Gene Delivery
2005 - Nature Portfolio | Nature Chemical Biology
Xi‐an Mao, William H. Gmeiner,
... imino exchanging at a medium rate. In the quadruplex G(1), G(5), G(10) and G(14) ...
Tópico(s): RNA Interference and Gene Delivery
2004 - Elsevier BV | Biophysical Chemistry
... peculiar structures such as T-loop and G-quadruplex. G-quadruplex is a poor substrate for telomerase activity ...
Tópico(s): Click Chemistry and Applications
2004 - Bentham Science Publishers | Current Medicinal Chemistry - Anti-Cancer Agents
Mark S. Kaucher, Yui‐Fai Lam, Silvia Pieraccini, Giovanni Gottarelli, Jeffery T. Davis,
... diffusion NMR confirmed formation of a hexadecameric G‐quadruplex [G 1 ] 16 ⋅ 4 K + ⋅ 4 pic − in CD ...
Tópico(s): RNA and protein synthesis mechanisms
2004 - Wiley | Chemistry - A European Journal
... including homodipeptides and alanyl dipeptides, were separated using quadruplex (G‐quartet) DNA stationary phases in open‐tubular capillary ...
Tópico(s): Bacteriophages and microbial interactions
2004 - Wiley | Electrophoresis
Václav Brázda, Lucia Hároníková, Jack Liao, Miroslav Fojta,
... different types of quadruplexes (i-Motifs, minor groove quadruplexes, G-quadruplexes, etc.), the best described are G-quadruplexes ...
Tópico(s): RNA and protein synthesis mechanisms
2014 - Multidisciplinary Digital Publishing Institute | International Journal of Molecular Sciences