Jose A Román Ivorra, Ernesto Trallero‐Araguás, María López‐Lasanta, Laura Cebrián, L. Lojo, Belén López-Muñíz, Julia Fernández-Melon, Belén Núñez, Lucía Silva-Fernández, Raúl Veiga Cabello, Pilar Ahijado, Isabel de la Morena Barrio, N. Costas Torrijo, Belén Safont, Enrique Ornilla, Juliana Restrepo, Arantza Campo, José Luís Andreu, Elvira Díez, A. Lόpez Robles, Elena Bollo, Diego Benavent, David Vilanova, Sara Luján Valdés, Raúl Castellanos‐Moreira,
Objectives Real-world data regarding rheumatoid arthritis (RA) and its association with interstitial lung disease (ILD) is still scarce. This study aimed to estimate the prevalence of RA and ILD in patients with RA (RAILD) in Spain, and to compare clinical characteristics of patients with RA with and without ILD using natural language processing ( ... of unstructured clinical data from patients with adult RA and RAILD from nine hospitals between 2014 and ... it into a SNOMED-CT terminology. Prevalence of RA and RAILD were calculated, and a descriptive analysis ...
Tópico(s): Systemic Sclerosis and Related Diseases
2024 - BMJ | RMD Open
Photograph of a group of British officers on board the S. S. Tenasserim, taken by Willoughby Wallace Hooper in 1885. The photograph is one of a series ...
0000 - Gale Group | NCCO Photography
Huiyu Zhu, Yifei Guan, Wei Wang, Xinhui Liu, Sijia Wang, Ran Zheng, Yihan Li, Lei Liu, Hua Huang,
... important role in regulating tumor progression. Reniformin A (RA) is a natural compound isolated from the medicinal ... in the treatment of esophageal cancer. However, whether RA has an individual function in cancer and the ... that in non-small-cell lung cancer (NSCLC), RA inhibits tumor growth by functioning as a pyroptosis ... promote TLR4/NLRP3/caspase-1/GSDMD axis. Specially, RA treatment increased Toll-like receptor 4 (TLR4) protein ... Based on the molecular docking, we identified that RA directly bound to TLR4 to activate the NLRP3 ...
Tópico(s): interferon and immune responses
2024 - Elsevier BV | International Immunopharmacology
The Ra Lakha's temple or Sun Temple at Kotai dates from the 10th Century circa and faces west. ...
0000 - Gale Group | NCCO Photography
Elizabeth Park, Joan M. Bathon,
Purpose of review Rheumatoid arthritis (RA) patients remain at higher cardiovascular (CV) risk compared to non-RA patients, driven by accelerated atherosclerosis, leading to plaque rupture and ... on arterial disease and myocardial disease. Recent findings RA patients demonstrate higher prevalence of subclinical atherosclerosis (high risk plaque and arterial inflammation) compared to non-RA patients, with RA disease activity correlating independently with CVE and death. ... preserved ejection fraction (HFpEF) is more common in RA compared to non-RA, with subclinical myocardial structural ...
Tópico(s): Acute Myocardial Infarction Research
2024 - Lippincott Williams & Wilkins | Current Opinion in Rheumatology
BioOne
... and believed responsible for murder of Israeli at Ra'anan. 13 July - 24 August 1954. FO 371/ ...
1954 - Gale Group | ArchivesUnbound Arabi Israeli
Jianmin Gong, Xiaoshan Zhang, Adeel Khan, Jun Liang, Tao Xiong, Ping Yang, Zhiyang Li,
Rheumatoid arthritis (RA) is an autoimmune disorder characterized by inflammation-induced joint damage, which can cause lasting disability. Therefore, early diagnosis and treatment of RA are crucial. Herein, we evaluated whether exosomal microRNAs ( ... promising biomarkers that can accelerate the diagnosis of RA and development of therapies for RA. First, we performed small RNA sequencing to determine ... a screening cohort comprised of 18 untreated active RA patients, along with 18 age and gender-matched ...
Tópico(s): Systemic Lupus Erythematosus Research
2024 - Elsevier BV | International Immunopharmacology
BioOne
James Barry Ra* 1741-1806 Art. Professor of Painting at the Royal Academy.
0000 - Gale Group | NCCO British Theatre
Andrew P. Creagh, Valentin Hamy, Hang Yuan, Gert Mertes, Ryan E. Tomlinson, Wen‐Hung Chen, Rachel E. Williams, Christopher Llop, Christopher Yee, Mei Sheng Duh, Aiden Doherty, Luis Garcia‐Gancedo, David A. Clifton,
... augment current in-clinic assessments for rheumatoid arthritis (RA), to enable better assessment of disease progression and ... could augment patient reported outcomes (PRO) to determine RA status and severity in a study of 30 moderate-to-severe RA patients, compared to 30 matched healthy controls (HC). ... of health status, mobility, dexterity, fatigue, and other RA specific symptoms were extracted from daily iPhone guided ... developed a machine learning (ML) framework to distinguish RA status and to estimate RA severity. It was ...
Tópico(s): Systemic Lupus Erythematosus Research
2024 - Nature Portfolio | npj Digital Medicine
OECD iLibrary
James Barry Ra* 1741-1806 Art. Professor of Painting at the Royal Academy.
0000 - Gale Group | NCCO British Theatre
Hao Cai, J Zhang, Hua Xu, Weiwei Sun, Weijie Wu, Chen Dong, Ping Zhou, Chengbin Xue, Yunyi Nan, Yingchen Ni, X. D. Wu, Zhifeng Gu, Minhao Chen, Youhua Wang,
... is linked to the pathology of rheumatoid arthritis (RA). Here, we investigated the molecular mechanism underlying pyroptosis in T cells isolated from patients with RA. Compared with healthy individuals, patients with RA had more pyroptotic CD4 + T cells in blood ... increased in CD4 + T cells from patients with RA and, among patients with RA, were lowest in those in clinical remission. Knockdown ... and improved symptoms in two rodent models of RA. Mechanistically, the increase in ALOX5 activity in RA CD4 + T cells enhanced the production of the ...
Tópico(s): IL-33, ST2, and ILC Pathways
2024 - American Association for the Advancement of Science | Science Signaling
Alexander Street
James Barry Ra* 1741-1806 Art. Professor of Painting at the Royal Academy. Correspondence. Apr. 18 1805. £25. Towards the Subscription ...
0000 - Gale Group | NCCO British Theatre
Yanhui Peng, Yurong Huang, Hui Li, Chen Li, Yajie Wu, Xiaomei Wang, Qiang Wang, Juan He, Chenggui Miao,
Rheumatoid arthritis (RA) is an autoimmune inflammatory disease that primarily affects the joints. Individuals at risk for RA and people with RA develop intestinal dysbiosis. The changes in intestinal flora composition in preclinical and confirmed RA patients suggest that intestinal flora imbalance may play ... important role in the induction and persistence of RA. Based on the current research on the interaction between RA and intestinal microbiota, intestinal microbiota metabolites and intestinal ... systematically summarized the changes in intestinal microbiota in RA patients, the metabolites of intestinal flora, and the ...
Tópico(s): Probiotics and Fermented Foods
2024 - Elsevier BV | Microbial Pathogenesis
James Barry Ra* 1741-1806 Art. Professor of Painting at the Royal Academy.
0000 - Gale Group | NCCO British Theatre
Produção Nacional
Revisado por pares
Olivia C. Leavy, Letícia Kawano-Dourado, Iain Stewart, Jennifer K Quint, Joshua J. Solomon, Raphaël Borie, Bruno Crestani, Louise V. Wain, Gisli Jenkins, Philippe Dieudé, Cosetta Minelli,
... up to 40% of individuals with rheumatoid arthritis (RA)-associated interstitial lung disease (RA-ILD). The RA-UIP phenotype could result from either a causal relationship of RA on UIP or vice versa, or from a simple co-occurrence of RA and IPF due to shared demographic, genetic or ... test the hypothesis of a causal effect of RA on UIP and of UIP on RA, using variants from genome-wide association studies (GWAS) of RA (separately for seropositive (18 019 cases and 991 ... seronegative (8515 cases and 1 015 471 controls) RA) and of IPF (4125 cases and 20 464 ...
Tópico(s): Pneumonia and Respiratory Infections
2024 - BMJ | Thorax
James Barry Ra* 1741-1806 Art. Professor of Painting at the Royal Academy.
0000 - Gale Group | NCCO British Theatre
Karim Gariani, Alessandro Putzu,
... liraglutide, lixisenatide, semaglutide, dulaglutide) and one GLP-1 RA taken orally (oral semaglutide) (Table 1). Furthermore, a dual agonist GLP-1/gastric inhibitory polypeptide (GIP) RA named tirzepatide has recently been approved in several ... acute pancreatitis and pancreatic cancer with GLP-1 RA use, but subsequent studies found no evidence for ... higher chances of these problems with GLP-1 RA use, especially for long durations, higher doses, and ... 8 Gastric emptying delay, independent of GLP-1 RA administration, is not rare in diabetic patients, as ...
Tópico(s): Metabolism, Diabetes, and Cancer
2024 - Lippincott Williams & Wilkins | European Journal of Anaesthesiology
Photograph of Jain temples and Ra Khengar's Palace on Mount Girnar near Junagadh in Gujarat, taken by the travelling commercial photographer F. Nelson in the 1890s ...
0000 - Gale Group | NCCO Photography
Cuntang Wang, Yueyi Lu, Xuanzhe An, Yuqing Wang, Ning Wang, Yang Song, Nan Hu, Manni Ren,
An intelligent pH-responsive indicator film (CA/CMC/RA) was fabricated by blending carrageenan (CA), carboxymethylcellulose (CMC), and rose anthocyanin (RA). Fourier transform infrared spectroscopy revealed the formation of hydrogen bonds between CA/CMC and RA. X-ray diffraction analysis demonstrated that the addition of RA enhanced the crystallinity of CA/CMC films. The incorporation of RA altered the microstructure of CA/CMC composite films, resulting in a roughened surface. RA improved the a*, b*, thickness, opacity, and water ...
Tópico(s): Seaweed-derived Bioactive Compounds
2024 - Elsevier BV | LWT