Mariana K. Najjar, Sara G. Manore, Angelina T. Regua, Hui‐Wen Lo,
Human epidermal growth factor receptor 2 (HER2) receptor tyrosine kinase is overexpressed in 20–30% of breast cancers and is associated with poor prognosis and worse overall patient survival. Most women with HER2-positive breast cancer receive neoadjuvant chemotherapy plus HER2-targeted therapies. The development of HER2-directed therapeutics is an important advancement in targeting invasive breast cancer. Despite the efficacy of anti-HER2 monoclonal antibodies, they are still being combined with ...
Tópico(s): Cancer Treatment and Pharmacology
2022 - Multidisciplinary Digital Publishing Institute | Genes
Angelina T. Regua, Mariana K. Najjar, Hui‐Wen Lo,
Rearranged during transfection (RET) receptor tyrosine kinase was first identified over thirty years ago as a novel transforming gene. Since its discovery and subsequent pathway characterization, RET alterations have been identified in numerous cancer types and are most prevalent in thyroid carcinomas and non-small cell lung cancer (NSCLC). In other tumor types such as breast cancer and salivary gland carcinomas, RET alterations can be found at lower frequencies. Aberrant RET activity is associated ...
Tópico(s): Lung Cancer Treatments and Mutations
2022 - Frontiers Media | Frontiers in Oncology
Sherona Sirkisoon, Grace L. Wong, Noah R. Aguayo, Daniel Doheny, Dongqin Zhu, Angelina T. Regua, Austin Arrigo, Sara G. Manore, Calvin J. Wagner, Alexandra Thomas, Ravi Singh, Fei Xing, Guangxu Jin, Kounosuke Watabe, Hui‐Wen Lo,
Mechanisms underlying breast cancer brain metastasis (BCBM) are still unclear. In this study, we observed that extracellular vesicles (EVs) secreted from breast cancer cells with increased expression of tGLI1, a BCBM-promoting transcription factor, strongly activated astrocytes. EV-derived microRNA/miRNA microarray revealed tGLI1-positive breast cancer cells highly secreted miR-1290 and miR-1246 encapsulated in EVs. Genetic knockin/knockout studies established a direct link between tGLI1 and both ...
Tópico(s): Circular RNAs in diseases
2022 - Elsevier BV | Cancer Letters
Angelina T. Regua, Noah R. Aguayo, Sara Abu Jalboush, Daniel Doheny, Sara G. Manore, Dongqin Zhu, Grace L. Wong, Austin Arrigo, Calvin J. Wagner, Yang Yu, Alexandra Thomas, Michael D. Chan, Jimmy Ruiz, Guangxu Jin, Roy E. Strowd, Peiqing Sun, Jiayuh Lin, Hui‐Wen Lo,
JAK2–STAT3 and TrkA signaling pathways have been separately implicated in aggressive breast cancers; however, whether they are co-activated or undergo functional interaction has not been thoroughly investigated. Herein we report, for the first time that STAT3 and TrkA are significantly co-overexpressed and co-activated in triple-negative breast cancer (TNBC) and HER2-enriched breast cancer, as shown by immunohistochemical staining and data mining. Through immunofluorescence staining–confocal microscopy ...
Tópico(s): Cancer Cells and Metastasis
2021 - Multidisciplinary Digital Publishing Institute | Cancers
Angelina T. Regua, Austin Arrigo, Daniel Doheny, Grace L. Wong, Hui‐Wen Lo,
Tópico(s): Cancer Research and Treatments
2021 - Elsevier BV | Cancer Letters
Daniel Doheny, Sherona Sirkisoon, Richard L. Carpenter, Noah R. Aguayo, Angelina T. Regua, Marlyn Anguelov, Sara G. Manore, Austin Arrigo, Sara Abu Jalboush, Grace L. Wong, Yu Yang, Calvin J. Wagner, Michael D. Chan, Jimmy Ruiz, Alexandra Thomas, Roy E. Strowd, Jiayuh Lin, Hui‐Wen Lo,
Triple-negative breast cancer (TNBC) and HER2-positive breast cancer are particularly aggressive and associated with unfavorable prognosis. TNBC lacks effective treatments. HER2-positive tumors have treatment options but often acquire resistance to HER2-targeted therapy after initial response. To address these challenges, we determined whether novel combinations of JAK2-STAT3 and SMO-GLI1/tGLI1 inhibitors synergistically target TNBC and HER2 breast cancer since these two pathways are concurrently ...
Tópico(s): Ubiquitin and proteasome pathways
2020 - Springer Nature | Oncogene
Sherona Sirkisoon, Richard L. Carpenter, Tadas Rimkus, Daniel Doheny, Dongqin Zhu, Noah R. Aguayo, Fei Xing, Michael D. Chan, Jimmy Ruiz, Linda J. Metheny‐Barlow, Roy E. Strowd, Jiayuh Lin, Angelina T. Regua, Austin Arrigo, Marlyn Anguelov, Boris Pasche, Waldemar Debinski, Kounosuke Watabe, Hui‐Wen Lo,
Mechanisms for breast cancer metastasis remain unclear. Whether truncated glioma-associated oncogene homolog 1 (TGLI1), a transcription factor known to promote angiogenesis, migration and invasion, plays any role in metastasis of any tumor type has never been investigated. In this study, results of two mouse models of breast cancer metastasis showed that ectopic expression of TGLI1, but not GLI1, promoted preferential metastasis to the brain. Conversely, selective TGLI1 knockdown using antisense ...
Tópico(s): Cancer Cells and Metastasis
2019 - Springer Nature | Oncogene
Angelina T. Regua, Csaba Papp, Andre Grageda, Baylee A. Porter, Tiffany Caza, Isabelle Bichindaritz, Mira Krendel, Abirami Sivapiragasam, Gennady Bratslavsky, Vladimir A. Kuznetsov, Leszek Kotula,
Despite the current standard of care, breast cancer remains one of the leading causes of mortality in women worldwide, thus emphasizing the need for better predictive and therapeutic targets. ABI1 is associated with poor survival and an aggressive breast cancer phenotype, although its role in tumorigenesis, metastasis, and the disease outcome remains to be elucidated. Here, we define the ABI1-based seven-gene prognostic signature that predicts survival of metastatic breast cancer patients; ABI1 ...
Tópico(s): Epigenetics and DNA Methylation
2021 - Elsevier BV | Molecular Oncology
Produção Nacional
Revisado por pares
Adriana Hamond Regua‐Mangia, Tânia A. T. Gomes, Mônica A. M. Vieira, Kinue Irino, Lúcia Martins Teixeira,
Enteroaggregative Escherichia coli (EAEC) strains have been implicated as emerging aetiological agents of diarrhoea worldwide. In the present study, 43 EAEC strains were serotyped and characterized according to random amplification of polymorphic DNA profiles, PFGE, multilocus enzyme electrophoresis (MLEE) and the presence of putative virulence genes (hly, aero, kps, fim, aggA, aafA, aggR, astA, she, aap, shf and pet). The EAEC strains consisted of a diversity of serotypes including eight O-non-typable ...
Tópico(s): Probiotics and Fermented Foods
2009 - Microbiology Society | Journal of Medical Microbiology
Produção Nacional
Revisado por pares
Adriana Hamond Regua‐Mangia, Tânia A. T. Gomes, Mônica A. M. Vieira, João Ramos Costa Andrade, Kinue Irino, Lúcia Martins Teixeira,
Tópico(s): Salmonella and Campylobacter epidemiology
2003 - Elsevier BV | Journal of Infection
Tadas Rimkus, Austin Arrigo, Dongqin Zhu, Richard L. Carpenter, Sherona Sirkisoon, Daniel Doheny, Angelina T. Regua, Grace L. Wong, Sara G. Manore, Calvin J. Wagner, Hui‐Kuan Lin, Guangxu Jin, Jimmy Ruiz, Michael D. Chan, Waldemar Debinski, Hui‐Wen Lo,
Whether tumor suppressor candidate 2 (TUSC2) plays an important role in glioblastoma (GBM) progression is largely unknown. Whether TUSC2 undergoes polyubiquitination is unknown. Herein, we report that TUSC2 protein expression is reduced/lost in GBM compared to normal brain due to protein destabilization; TUSC2 mRNA is equally expressed in both tissues. NEDD4 E3 ubiquitin ligase polyubiquitinates TUSC2 at residue K71, and the TUSC2-K71R mutant is resistant to NEDD4-mediated proteasomal degradation. ...
Tópico(s): Cancer, Hypoxia, and Metabolism
2022 - Elsevier BV | Cancer Letters
Produção Nacional
Revisado por pares
Rubismar Stolf, Jorge Hiroshi Murakami, Miguel Angelo Maniero, Márcio Roberto Soares, Luiz Carlos Ferreira da Silva,
... solo. A utilização do equipamento com leitura na régua resultou em um tempo médio 21 % menor (teste t, 1 %). Além de reduzir o tempo de amostragem, ...
Tópico(s): Soil Mechanics and Vehicle Dynamics
2012 - Sociedade Brasileira de Ciência do Solo | Revista Brasileira de Ciência do Solo
Angelina T. Regua, Shivani Bindal, Mariana K. Najjar, Chuling Zhuang, Munazza S. Khan, Austin Arrigo, Anneliese Gonzalez, Xinhai R. Zhang, Jay‐Jiguang Zhu, Kounosuke Watabe, Hui‐Wen Lo,
HER2-positive and triple-negative breast cancers (TNBC) are difficult to treat and associated with poor prognosis. Despite showing initial response, HER2-positive breast cancers often acquire resistance to HER2-targeted therapies, and TNBC lack effective therapies. To overcome these clinical challenges, we evaluated the therapeutic utility of co-targeting TrkA and JAK2/STAT3 pathways in these breast cancer subtypes. Here, we report the novel combination of FDA-approved TrkA inhibitors (Entrectinib ...
Tópico(s): Lung Cancer Treatments and Mutations
2024 - Elsevier BV | Cancer Letters
Produção Nacional
Revisado por pares
Mônica Merçon, Adriana Hamond Regua‐Mangia, Lúcia Martins Teixeira, Kinue Irino, Suely Tuboi, R.T. Gonçalves, Guilherme Santoro‐Lopes,
Urinary tract infection (UTI) is the most common infectious complication after renal transplantation. Most infections are caused by uropathogenic Escherichia coli (UPEC). There are limited data on the prevalence of virulence traits among UPEC isolated from renal transplant recipients. This study compared the phenotypic and genotypic profiles of UPEC strains isolated from recipients with those from control patients.E coli isolates that caused UTI in recipients versus nonimmunosuppressed control patients ...
Tópico(s): Gut microbiota and health
2010 - Elsevier BV | Transplantation Proceedings
Produção Nacional
Revisado por pares
Adriana Hamond Regua‐Mangia, Tânia A. T. Gomes, João Ramos Costa Andrade, Mônica A. M. Vieira, Alice Gonçalves Martins Gonzalez, Viviane Zahner, Kinue Irino, Lúcia Martins Teixeira,
In the present study, 47 enteropathogenic Escherichia coli strains identified according to serotyping, presence of eae, bfp and EAF sequences, adherence phenotype and ability to induce attaching-effacing lesions were analyzed by pulsed-field gel electrophoresis (PFGE), multilocus enzyme electrophoresis (MLEE), and the presence of LEE genes (eae, espA, espB, tir) as well as the respective alleles. Amplification of LEE genes subtypes revealed 18 different pathotypes. Typing of the eae gene showed that ...
Tópico(s): Probiotics and Fermented Foods
2003 - Springer Nature | Brazilian Journal of Microbiology
Produção Nacional
Revisado por pares
Diana Azeredo Rangel, Cristiane Varella Lisboa, Roberto Leonan Morim Novaes, Bruno Alves Silva, Renan De França Souza, Ana María Jansen, Ricardo Moratelli, André Luiz Rodrigues Roque,
... in bats from the two areas: 15% in REGUA and 11% in EFMA (p = 0.46). Trypanosoma dionisii was the most frequently detected parasite (54%), followed by T. cruzi DTUs TcI and TcIV and Trypanosoma sp., ...
Tópico(s): Vector-borne infectious diseases
2019 - Public Library of Science | PLoS neglected tropical diseases
Austin Arrigo, Angelina T. Regua, Mariana K. Najjar, Hui‐Wen Lo,
Tumor Suppressor Candidate 2 (TUSC2) was first discovered as a potential tumor suppressor gene residing in the frequently deleted 3p21.3 chromosomal region. Since its discovery, TUSC2 has been found to play vital roles in normal immune function, and TUSC2 loss is associated with the development of autoimmune diseases as well as impaired responses within the innate immune system. TUSC2 also plays a vital role in regulating normal cellular mitochondrial calcium movement and homeostasis. Moreover, TUSC2 ...
Tópico(s): Immune cells in cancer
2023 - Multidisciplinary Digital Publishing Institute | Cancers
Grace Lai‐Hung Wong, Mariana K. Najjar, Yoshua Esquenazi, Nitin Tandon, Angelina T. Regua, Hui‐Wen Lo,
... Wong, Mariana Najjar, Yoshua Esquenazi, Nitin Tandon, Angelina T. Regua, Hui-Wen Lo. Intracellular miR-1290 promotes breast ...
Tópico(s): Ferroptosis and cancer prognosis
2023 - American Association for Cancer Research | Cancer Research
Angelina T. Regua, Mariana K. Najjar, Grace L. Wong, Sara G. Manore, Austin Arrigo, Hui‐Wen Lo,
... and HER2-enriched breast cancers. Citation Format: Angelina T. Regua, Mariana K. Najjar, Grace L. Wong, Sara G. ...
Tópico(s): Cancer-related Molecular Pathways
2023 - American Association for Cancer Research | Cancer Research
Sara G. Manore, Daniel Doheny, Dongqin Zhu, Grace L. Wong, Angelina T. Regua, Austin Arrigo, Calvin J. Wagner, Mariana K. Najjar, Hui‐Wen Lo,
... L. Doheny, Dongqin Zhu, Grace L. Wong, Angelina T. Regua, Austin Arrigo, Calvin J. Wagner, Mariana Najjar, Hui- ...
Tópico(s): Cancer Research and Treatments
2022 - American Association for Cancer Research | Cancer Research
Daniel Doheny, Sara G. Manore, Grace L. Wong, Dongqin Zhu, Sherona Sirkisoon, Marlyn Anguelov, Noah R. Augayo, Angelina T. Regua, Anderson O. Cox, Cristina M. Furdui, Terrence L. Smalley, Alexandra Thomas, Adrianna Masters, Roy E. Strowd, Hui‐Wen Lo,
... Sherona Sirkisoon, Marlyn Anguelov, Noah R. Augayo, Angelina T. Regua, Anderson Cox, Cristina Furdui, Terrence Smalley, Alexandra Thomas, ...
Tópico(s): Cancer Mechanisms and Therapy
2022 - American Association for Cancer Research | Cancer Research
Grace L. Wong, Sherona Sirkisoon, Noah R. Aguayo, Daniel Doheny, Dongqin Zhu, Angelina T. Regua, Austin Arrigo, Sara G. Manore, Calvin J. Wagner, Alexandra Thomas, Ravi Singh, Fei Xing, Guangxu Jin, Kounosuke Watabe, Hui‐Wen Lo,
... R. Aguayo, Daniel L. Doheny, Dongqin Zhu, Angelina T. Regua, Austin Arrigo, Sara G. Manore, Calvin J. Wagner, ...
Tópico(s): Chemokine receptors and signaling
2022 - American Association for Cancer Research | Cancer Research
Angelina T. Regua, Dongqin Zhu, Daniel Doheny, Grace L. Wong, Sara G. Manore, Calvin J. Wagner, Austin Arrigo, Mariana K. Najjar, Hui‐Wen Lo,
... and triple-negative breast cancers. Citation Format: Angelina T. Regua, Dongqin Zhu, Daniel L. Doheny, Grace L. Wong, ...
Tópico(s): Cancer, Hypoxia, and Metabolism
2022 - American Association for Cancer Research | Cancer Research
Angelina T. Regua, Noah R. Aguayo, Sara Abu Jalboush, Daniel Doheny, Sara G. Manore, Dongqin Zhu, Grace L. Wong, Austin Arrigo, Calvin J. Wagner, Yang Yu, Karen Baylon, Alexandra Thomas, Michael D. Chan, Jimmy Ruiz, Guangxu Jin, Roy E. Strowd, Peiqing Sun, Linda J. Metheny‐Barlow, Jiayuh Lin, Hui‐Wen Lo,
... breast cancers of both subtypes. Citation Format: Angelina T. Regua, Noah R. Aguayo, Sara Abu Jalboush, Daniel L. ...
Tópico(s): Cancer-related Molecular Pathways
2021 - American Association for Cancer Research | Cancer Research
Angelina T. Regua, Dongqin Zhu, Austin Arrigo, Daniel Doheny, Hui‐Wen Lo,
... in GBM and breast cancer. Citation Format: Angelina T. Regua, Dongqin Zhu, Austin Arrigo, Daniel Doheny, Hui-Wen ...
Tópico(s): Ubiquitin and proteasome pathways
2020 - American Association for Cancer Research | Cancer Research
Wei Cheng, Stephen D. Shafran, Kimberly L. Beavers, Hongmei Mo, J. McNally, Diana M. Brainard, William T. Symonds, Mario Chojkier, Adriana Hamond Regua Mangia, Christopher Schwabe,
Tópico(s): Hepatitis C virus research
2014 - Elsevier BV | Journal of Hepatology
Produção Nacional
Revisado por pares
Juliana Caierão, José Augusto Cardoso Dias Paiva, Jorge Luiz Mello Sampaio, Marlei Gomes da Silva, Débora Ribeiro de Souza Santos, Fábrice Santana Coelho, Leila de Souza Fonseca, Rafael Silva Duarte, Derek T. Armstrong, Adriana Hamond Regua‐Mangia,
Rapidly growing mycobacteria (RGM) have emerged as important pathogens in clinical settings, associated with esthetic procedures and postsurgical infections, pulmonary infections among cystic fibrosis patients, and other structural pulmonary diseases. Microorganisms belonging to Mycobacterium abscessus-Mycobacterium chelonae and to Mycobacterium fortuitum groups have frequently been associated with outbreaks and various epidemics. In the present study, RGM strains were characterized in order to investigate ...
Tópico(s): Actinomycetales infections and treatment
2015 - Elsevier BV | International Journal of Infectious Diseases
Angelina T. Regua, Noah R. Aguayo, Sara Abu Jalboush, Daniel Doheny, Sara G. Manore, Dongqin Zhu, Grace L. Wong, Austin Arrigo, Calvin J. Wagner, Yang Yu, Alexandra Thomas, Michael D. Chan, Jimmy Ruiz, Guangxu Jin, Roy Strowd, Peiqing Sun, Jiayuh Lin, Hui-Wen Lo,
In the original publication [...].
Tópico(s): Cancer-related Molecular Pathways
2024 - Multidisciplinary Digital Publishing Institute | Cancers
Produção Nacional
Revisado por pares
Rafaella De Angeli Curto, Gilson Fernandes da Silva, Carlos Pedro Boëchat Soares, Leandro Tose Martins, Hassan Camil David,
... clinômetro digital (2); estimação com auxílio de uma régua de 15 metros (3); e estimações visuais com treinamento (4) e sem treinamento (5), em três classes de altura: 1 (15,00-17,99 m); 2 (18,00-20,99 m); e 3 (> 21,00 m). Foram mensurados 124 indivíduos em terreno plano e 87 em terreno inclinado. Os dados de altura foram comparados pelo teste t, análises gráficas de resíduos e estatísticas complementares. Para ...
Tópico(s): Soil Management and Crop Yield
2013 - UNIVERSIDADE FEDERAL DO PARANÁ | FLORESTA
Kalpana Gupta, Barbara W. Trautner,
... S54-7. [PMID:18054467] Google Scholar23. Merçon M, Regua-Mangia AH, Teixeira LM, et al. Urinary tract infections in renal transplant recipients: virulence traits of uropathogenic Escherichia coli. Transplant Proc. 2010;42:483-5. [PMID:20304171] Google Scholar24. Nicolle LE. Catheter-related urinary tract infection. Drugs Aging. 2005;22:627-39. [PMID:16060714] Google Scholar25. Ulleryd P, Zackrisson B, Aus G, Bergdahl S, Hugosson J, Sandberg T. Selective urological evaluation in men with febrile urinary ...
Tópico(s): Urinary Bladder and Prostate Research
2012 - American College of Physicians | Annals of Internal Medicine