Lance Low, Phil Yates, Giles Tremlett, John Naughton, Tunku Varadarajan, Jon Ashworth, Matthew Wall, Raymond Snoddy Media Editor, Paul McCarthy, Andrew Pierce, Political Correspondent, Paul Heiney, Alasdair Riley, Jonathan Goodall, Richard Whitehead, Carolie Doyle, Brian Greer, Alfred Dunhill, Alexandra Frean, Nigel Colborn, S. G. John, Robert Cranston, Lottle Moggach, Jane MacQuitty, Simon Barnes, Annabel Levy, John Morgan, Robin C. Davis, Paul Hoggart, Mark Souster, Richard Hobson, Lee Brown, John Diamond, Donna Francesca, Adrian Sherratt, Gavin Lumsden, Ivo Tennant, Terence Blacker, Philip Howard, Carol Midgley, John A. Harries-Harris, Janet Bush Economics Editor, Adam Cooper, Patrick Collinson, George Sivell, Clive Davis, Oliver Holt Football Correspondent, Peter Foster, Michael Lowy, Lynne Truss, Marion Bayliss, 'Mitch Jenkins, Nick Nuttall, Environment Correspondent, Tony Patrick, William Ruxton (Security consultant), Margareta Pagano, Jeremy Seal, Clare Stewart, Geoff Brown, Louise Godfrey, Joanne Episcopo, Lawrence Dallaglio, Julian Desborough, Karl Johnston, Lloyd-Webber, Robert Sheehan, D. R., Steve Keenan, John Hopkins, Golf Correspondent, Fukhera Khalid, Dominic Walsh, Ruth Gledhill, Debra Craine, Carol Midgley and Frances Gibb, Anthony Hopkins, Alan Road, E. Biggart, Michael Hofmann, Carol Price, Peter Waymark, Robin Young, Rodney Milnes, Lord Montagu of Beaulieu, Andrew J. Bullock, Barbara Abbs, Michael Clark, Eve-Ann Prentice, T. P., Doug Sager, Keith Pike, John D. Wardlaw, Frances Bissell, David Hands, P. B., Anna Blundy, Michael Cable, Martin Symington, Jonathan Sacks, Peter Barnard, Edward Gorman, Derwent May, Mary Loudon, Philip Gooden, Lisa Jardine, Graham Wood, melvyn evans, Jasper Gerard, Charley Speed, Russell Kempson, Lizanne Rose, Caroline Griffiths, Sara Taylor, Daniel McGrory, Stephen Anderton, Paul Durman, Sarah Johnson, simon battensby, David Ashcroft, Sophie Campbell, Helen Wallace, George Brock, Andrew Sellon, A. Beniston, Gerald Cole, John Hopkins, L. G., Jill Insley, David Baddiel, Barry Millington, Simon de Bruxelles, Colin Lester, Paul Redgrave, Adam Jones, Victoria O'Brien, Barbara Buxton, Raymond Keene, Ray Main, Philip Taylor, David Charter, Education Correspondent, David Robinson, Kate Saunders, John Russell Taylor, Dominic Lutyens, Matt Dickinson, Jackie Farry, P. W., Karen Zagor, Vivien Duffield bids, James Allcock, Stefano Hatfield, jean cazals, Andrew Phillips, Chairman, Richard Evans, Imogen Edwards-Jones, Caroline Merrell, Frances Gibb and Nicholas Wood, Robin Neillands, Paul Lambert, John Morrish, Turner & Hooch, Anthony A. Rhodes, Bronwen Maddox, Oliver Holt, Richard Owen, Sandra Parsons, John Givens, Marcel Berlins, Martin Rantzen, David Palmer, Nicholas Watt and Philip Webster, Oliver August, Roger Norrington, Michael Hornsby, Agriculture Correspondent, Stephanie Billen, Danny Wilson, Nicholas Wood, BN, Anne Ashworth, Joanna Pitman, Dominic Kennedy, Giles Whittell, Sara McConnell, David Rudnick, Robert Bonnier, Simon De Bruxelles, Kathryn Knight and Paul Whittaker, Jane Shilling, Sean Coughlan, Mel Webb, Gary Barlow, Tunku Varadarajan's, Srikumar Sen Boxing Correspondent, Philip Delves Broughton, Deborah King, Matthew Parris, Richard Evans Racing Correspondent, Mark Hodkinson, Alan Franks, Chris McGrath, Oliver Reed, Michael Hornsby, Tim Wapshott, Johnny Acton, Simon Chapman, Kate Muir's, Philip Beresford, frazer hudson, Ben MacIntyre, Anthony d'offay Gallery, Helen Pridham, Michael Gove, Brian Glanville, Ben Macintyre, Mickey Finn, Graham Searjeant, John Naish, Simon Jenkins, Anne Ashworth Personal Finance Editor, Steve McManaman, JRT, Martin Waller, Chris Ayres, Peter Ingham, Lisa Verrico, Danny Baker, Martyn Thompson, Heath Brown, Benedict Nightingale, Tom Rhodes, Jonathan Meades, Marianne Curphey, Jill Crawshaw, Julian Muscat Tennis Correspondent, David Arnold, Chris Moore, Valerie Grove, K. E. Sayers, David Maddock, Charlie Porter, Alan Jackson, Anthony Seldon's, Prince Edward, Susannah Jowitt, Colin Renfrew, Nigel McCulloch, sheila keating, Matthew Wyatt, Kevin Eason, Motoring Editor, Christopher Irvine,
... twin I legend is reborn John Naish on RTV's vintage new superbike Multiple Classified Advertising Items ...
1997 - Gale Group | TDA
Eun-Ju Jung, Woo-Jin Lee, Ju-Mi Hwang, Jeong-Won Bae, Woo‐Sung Kwon,
... treatment. Among the numerous potential therapeutic agents, ritonavir (RTV), an anti-viral agent, has recently been identified ... important element of the COVID-19 treatment. Moreover, RTV has also been applied in the drug repurposing ... cancer cells. However, previous studies have shown that RTV has toxic effects on various cell types. In addition, RTV regulates AKT phosphorylation within cancer cells, and AKT ... capacitation, and so on). Although deleterious effects of RTV have been reported, it is not known whether ...
Tópico(s): Ovarian function and disorders
2022 - Elsevier BV | Reproductive Toxicology
Arif Budiman, Diah Lia Aulifa,
... mesoporous silica (MPS) and pure amorphous drugs. Ritonavir (RTV) was used as a model of a poorly ... soluble drug due to its low recrystallization tendency. RTV loaded-MPS (RTV/MPS) and RTV amorphous were prepared using the solvent evaporation method. ... differential scanning calorimetry (MDSC) curve was discovered in RTV amorphous, indicating its amorphization. The Tg was not detected in RTV/MPS, which showed that the loading RTV was completed. The solid-state NMR and FT-IR spectroscopy also showed the interaction between RTV and the surface of MPS in the mesopores. ...
Tópico(s): Mesoporous Materials and Catalysis
2022 - Multidisciplinary Digital Publishing Institute | Pharmaceuticals
DrashtiSunil Gandhi, Rajesh Sethuraman,
... 1% trisnorbornenylisobutyl polyhedralsilsesquioxanes (POSS) modified room temperature vulcanizing (RTV) maxillofacial silicone after a 6 - month artificial aging ... two samples comprising of 11 samples of conventional RTV silicone (Group 1) and 11 for POSS modified RTV silicone (Group 2) were fabricated in stainless steel ... tensile strength and tear strength of POSS-modified RTV silicone were significantly higher than conventional RTV silicone (P < 0.0001 and P = 0.00014, ... 0.0.0067, respectively), whereas the POSS-modified RTV silicone showed statistically nonsignificant results in L, a, ...
Tópico(s): Aerogels and thermal insulation
2022 - Springer Science+Business Media | The Journal of Indian Prosthodontic Society
Directory of Open Access Books (DOAB)
Satish Rojekar, Ajinkya M. Trimukhe, R.R. Deshmukh, Pradeep R. Vavia,
... pulsed oxygen plasma treatment (POPT) of the ritonavir (RTV) powder/compacts was investigated as a novel possible ... and, consequently, solubility of the poorly water-soluble RTV drug. Induction of POPT for 30 min enhanced ... 95-folds IDR at 24 h, attributed to RTV's surface hydrophilization. The POPT RTV exhibited zero contact angle compared to RTV suggesting improved wettability (untreated RTV = 74° and 30 min after POPT = 0°). The ... aided through POPT lead to improved wettability of RTV. Moreover, the increased negative zeta potential was observed ...
Tópico(s): Protein purification and stability
2021 - Elsevier BV | Journal of Drug Delivery Science and Technology
Hiram Villanueva-Lozano, Rogelio de J. Treviño‐Rangel, Gloria M. González, María Teresa Ramírez-Elizondo, Reynaldo Lara-Medrano, Mary Cruz Alemán-Bocanegra, Claudia Elena Guajardo-Lara, Natalia Gaona-Chávez, Fernando Castilleja‐Leal, Guillermo Torre‐Amione, Michel F. Martínez‐Reséndez,
... METROCRO, MEM, CAZ/ABI, LZDSARS-CoV-2 treatmentLPV/RTV, RBV, BARI, PLASMALPV/RTV, RBV, BARILPV/RTV, RBV, BARILPV/RTV, RBV, BARI, PLASMALPV/RTV, RBV, BARILPV/RTV, RBV, BARI, TOCI, PLASMALPV/RTV, RBV, BARI,LPV/RTV, RBV, BARI, PLASMALPV/RTV, RBV, BARILPV/RTV, RBV, BARI, TOCI, PLASMALPV/RTV, RBV, BARILPV/RTV, ...
Tópico(s): Parasitic Diseases Research and Treatment
2021 - Elsevier BV | Clinical Microbiology and Infection
Xiaofei Wang, Yihang Yu, Pei Wang, Kun Yang, Yi‐Ting Wang, Yan Liang, Xiao‐bo Zhong, Lirong Zhang,
Ritonavir (RTV), a pharmacoenhancer used in anti-HIV regimens, can induce liver damage. RTV is primarily metabolized by cytochrome P450 3A4 (CYP3A4) ... mechanisms of HNF4A-AS1 and HNF1A-AS1 in RTV-induced hepatotoxicity. HNF4A-AS1 and HNF1A-AS1 were ... reactive oxygen species assays were performed to assess RTV-induced hepatotoxicity. Chromatin immunoprecipitation quantitative real-time polymerase ... knockdown increased PXR and CYP3A4 expression and exacerbated RTV-induced cytotoxicity, whereas HNF1A-AS1 knockdown generated the ...
Tópico(s): Liver Disease Diagnosis and Treatment
2021 - American Society for Pharmacology and Experimental Therapeutics | Drug Metabolism and Disposition
Christophe Beyls, Nicolas Martin, Alexis Hermida, Osama Abou‐Arab, Yazine Mahjoub,
... was the combination of lopinavir (LPV) and ritonavir (RTV; Kaletra; Abbott Laboratories, Chicago, IL), previously used for ... of HIV-1 that is usually combined with RTV, another protease inhibitor that strongly inhibits hepatic CYP ( ... treat COVID-19 critically ill patients with LPV/RTV. For HIV-1 patients, a risk of bradycardia ... reported possibly due to nodal toxicity of LPV/RTV.3 To date, there are no data on bradycardia related to LPV/RTV treatment for COVID-19 critical ill patients. The ... bradycardia for COVID-19 patients treated with LPV/RTV.During the first month of the outbreak, patients ...
Tópico(s): Pharmacological Receptor Mechanisms and Effects
2020 - Lippincott Williams & Wilkins | Circulation Arrhythmia and Electrophysiology
Popat Kumbhar, Sonali K. Diwate, Uma Mali, Tejaswini Shinde, John Disouza, Arehalli S. Manjappa,
... the simultaneous estimation of docetaxel (DTX) and ritonavir (RTV) in PLGA nanoparticles (PLGA-NPs). The DTX and RTV co-loaded PLGA-NPs were developed by the ... ICH) guidelines. The chromatographic separations of DTX and RTV with good resolutions have been achieved by using ... 0.001–100 μg/mL for DTX and RTV. Detection and quantification limits for DTX were found ... and 2.31 μg/mL respectively and for RTV it is 0.3 and 2.87 μg/ ... used for the simultaneous estimation of DTX and RTV in the PLGA-NPs. L'objectif principal de ...
Tópico(s): Antibiotics Pharmacokinetics and Efficacy
2020 - Elsevier BV | Annales Pharmaceutiques Françaises
Saad Alhumaid, Abbas Al Mutair, Zainab Al Alawi, Naif Alhmeed, Abdul Rehman Zia Zaidi, Mansour Tobaiqy,
(Background) Lopinavir-ritonavir (LPV/RTV) is a human immunodeficiency virus (HIV) antiviral combination that has been considered for the treatment of COVID-19 disease. (Aim) ... to assess the efficacy and safety of LPV/RTV in COVID-19 patients in the published research. ( ... databases. This review evaluated the effects of LPV/RTV alone or in combination with standard care ± interferons/ ... did not report positive clinical outcomes with LPV/RTV treatment. In terms of virological cure, three studies ... days to achieve a virological cure for LPV/RTV arm relative to no antiviral treatment (−0.81 ...
Tópico(s): Pharmacological Effects and Toxicity Studies
2020 - Multidisciplinary Digital Publishing Institute | Tropical Medicine and Infectious Disease
Song‐Bo Kou, Kaili Zhou, Zhen‐Yi Lin, Yan‐Yue Lou, Baoli Wang, Jie‐Hua Shi, Ying-Xin Liu,
The binding behavior of ritonavir (RTV), a HIV/AIDS protease inhibitor, with ct-DNA was characterized through multiple testing technologies and theoretical calculation. The findings revealed that the RTV-DNA complex was formed through the noncovalent interaction ... interactions). The stoichiometry and binding constant of the RTV-DNA complex were 1:1 and 1.87 × ... M-1 at 298 K, respectively, indicating that RTV has moderate affinity with ct-DNA. The findings confirmed that RTV binds to the minor groove of DNA. The ...
Tópico(s): Protein Interaction Studies and Fluorescence Analysis
2020 - Taylor & Francis | Journal of Biomolecular Structure and Dynamics
Yannick Binois, Hafsah Hachad, Joe‐Elie Salem, Julien Charpentier, Bénédicte Lebrun‐Vignes, Frédéric Pène, Alain Cariou, Jean‐Daniel Chiche, Jean-Paul Mira, Lee S. Nguyen,
Lopinavir and low-dose ritonavir (LPV/RTV) are associated in a fixed-dose combination protease inhibitor therapy used in patients with HIV and AIDS. The recent outbreak of severe ... COVID-19) has rekindled the interest in LPV/RTV after preclinical studies.1Peele K.A. Chandrasai P. ... Scholar Although no benefit was observed with LPV/RTV treatment beyond standard care,2Cao B. Wang Y. ... are currently enrolling. Like other antiretroviral therapies, LPV/RTV has been previously associated with acute kidney injuries ( ...
Tópico(s): Neurological and metabolic disorders
2020 - Elsevier BV | Kidney International Reports
S Schmid, Rachel E. Cianciolo, Kenneth J. Drobatz, Melissa D. Sánchez, Joshua Price, Lesley G. King,
To describe the frequency of renal tubular vacuolization (RTV) as a surrogate of osmotic nephrosis and assess hyperosmolar agents as predictors of RTV severity.Retrospective study (February 2004-October 2014).Veterinary ... examination.None.The frequency, severity, and location of RTV were determined in small group of critically ill ... 0.75) and mannitol dose as predictors for RTV severity with presenting serum creatinine concentration, cumulative furosemide dose, and duration of hospitalization as covariates. RTV was noted in 45 (85%) of 53 critically ...
Tópico(s): Cardiovascular Conditions and Treatments
2019 - Wiley | Journal of Veterinary Emergency and Critical Care
... and properties of room-temperature vulcanizated silicone rubber (RTV) composites with a type of incompletely condensed polyhedral ... observed from SEM Then, TPOSS was applied in RTV composites. Properties of RTV/TPOSS composites such as swelling behavior, tensile strength, ... and forming the effective three-dimensional networks in RTV composites. Tensile tests revealed that the tensile strength of RTV/TPOSS-3 was 20% higher than that of pure RTV, and the elongation at break of RTV/TPOSS-1 also showed an improvement. Thermogravimetric analysis ...
Tópico(s): Flame retardant materials and properties
2016 - SAGE Publishing | Journal of Elastomers & Plastics
Xiaowei Dong, Shujie Guo, Kevin Pham, Diana Li, Scott Penzak,
... and methods: In one method, we prepared ritonavir (RTV) nanoparticles (NPs) by a microemulsion-precursor method and then converted the RTV NPs to solid granules by wet granulation to produce RTV NP-containing granules. In the other innovative method, ... in situ self-assembly nanoparticles (ISNPs). We prepared RTV ISNP granules that did not initially contain NPs, but spontaneously produced RTV ISNPs when the granules were introduced to water with gentle agitation. We fully characterized these RTV nanoformulations. We also used rats to test the ...
Tópico(s): Drug Solubulity and Delivery Systems
2016 - Dove Medical Press | International Journal of Nanomedicine
See Min Choi, Don Kyoung Choi, Tae Heon Kim, Byong Chang Jeong, Seong Il Seo, Seong Soo Jeon, Hyun Moo Lee, Han-Yong Choi, Hwang Gyun Jeon,
... investigate the difference between preoperative radiologic tumor volume (RTV) and postoperative pathologic tumor volume (PTV) in patients ... radical or partial nephrectomy for renal cell carcinoma. RTV measured by a three dimensional rendering program was ... of the inter-quartile range (IQR) of the RTV and Fuhrman nuclear grade was also investigated. Results There was a significant positive linear correlation between RTV and PTV (p<0.001, r = 0.911), and the mean RTV and mean PTV were not significantly different (79. ...
Tópico(s): MRI in cancer diagnosis
2015 - Public Library of Science | PLoS ONE
... 3b, open-label, study examining simplification from ritonavir (RTV)-boosted protease inhibitor (PI+RTV) plus emtricitabine/ tenofovir DF (FTC/TDF) regimens to ... HIV-1 infected, virologically suppressed subjects on PI+RTV + FTC/ TDF regimens for ≥ 6 months either switched to STB or remained on their PI+RTV regimen (2:1 randomization).Eligibility included estimated creatinine ( ... randomization, subjects (n=433, 293 STB; 140 PI+RTV) were mostly male (86%), white (80%) and age < 50 yr (82%).ATV+RTV (40%) or DRV+RTV (40%) were the most ...
Tópico(s): Mobile Health and mHealth Applications
2015 - Wiley | HIV Medicine
Carmen Pizarro, Robert Schueler, Christoph Hammerstingl, Izabela Tuleta, Georg Nickenig, Dirk Skowasch,
... lung emphysema. As its impact on right ventricular (RtV) function is undefined, we examined the extent of RtV functional changes following ELVR, as assessed by use of speckle tracking-based RtV deformation analysis. Methods We enrolled 32 patients with ... and 239.1% of predicted, respectively). After ELVR, RtV apical longitudinal strain improved significantly in the total ... were no significant changes in other parameters of RtV function such as RtV global longitudinal strain, TAPSE or pulmonary arterial systolic ...
Tópico(s): Chronic Obstructive Pulmonary Disease (COPD) Research
2015 - Public Library of Science | PLoS ONE
Jasimuddin Ahamed, Hunter Terry, Mary E. Choi, Jeffrey Laurence,
... 7]. Use of HIV protease inhibitors, particularly ritonavir (RTV), predicts increased carotid intima-media thickness, a subclinical marker of atherosclerosis [8]. Duration of RTV-boosted protease inhibitor use was the only significant ... 9]. Osteoporosis is similarly increased in patients on RTV-boosted protease inhibitors [10,11], an important observation ... cytokine levels. As one example, we found that RTV abrogates a physiologic block to the activity of ... to accelerated osteoclast formation in HIV+ women receiving RTV compared with those on non-RTV-based regimens [ ...
Tópico(s): Bone and Joint Diseases
2015 - Lippincott Williams & Wilkins | AIDS
Li Zhu, Matthew Hruska, Carey Hwang, Vaishali Shah, Michael Furlong, George J. Hanna, Richard Bertz, Ishani Landry,
... is a CYP3A4 substrate), atazanavir (ATV), and ritonavir (RTV) (ATV and RTV are CYP3A4 inhibitors). Thirty-six healthy subjects were ... BID), BMS-663068 at 600 mg BID plus RTV at 100 mg once daily (QD), ATV at 300 mg QD plus RTV at 100 mg QD (RTV-boosted ATV [ATV/r]), or BMS-663068 at ... BID plus ATV at 300 mg QD plus RTV at 100 mg QD. Compared with the results ... 54%, respectively. Similarly, coadministration of BMS-663068 with RTV increased the BMS-626529 C max and AUC ... by administration of ATV/r alone, ATV and RTV systemic exposures remained similar following coadministration of BMS- ...
Tópico(s): HIV/AIDS Research and Interventions
2015 - American Society for Microbiology | Antimicrobial Agents and Chemotherapy
Swapnil J. Dengale, Syed Sajjad Hussen, Bandarupalli Krishna, Prashant B Musmade, Gautham G. Shenoy, Krishnamurthy Bhat,
... excellent glass former. QRT was paired with Ritonavir (RTV) (BCS class-IV antiretroviral) to form stable amorphous ... and pharmacologically relevant combination. Binary amorphous forms of RTV and QRT in molar ratios 1:1, 1: ... studies at 40 °C for 90 days found RTV:QRT 1:2 and RTV:QRT 2:1 phases stable, while trace crystallinity ... for 1:1M ratio. The temperature stability of RTV:QRT 1:2 and RTV:QRT 2:1 amorphous forms can be attributed ... excess acts as a crystallization inhibitor. Except for RTV:QRT 1:2 ratio, there was no evidence ...
Tópico(s): Crystallization and Solubility Studies
2014 - Elsevier BV | European Journal of Pharmaceutics and Biopharmaceutics
Jin Xiang, Ying Wang, Ke Su, Min Liu, Pengchao Hu, Tian Ma, Jiaxi Li, Wei Lei, Zhongliang Zheng, Fang Yang,
... actions are closely related to cardiovascular disease. Ritonavir (RTV), a human immunodeficiency virus (HIV) protease inhibitor, induces atherosclerosis in an estrogen-related manner. However, how RTV induce pathological phenotypes through estrogen pathway remains unclear. In this study, we found that RTV increases thickness of coronary artery walls of Sprague ... plasma free fatty acids (FFA) levels. In addition, RTV could induce foam cell formation, downregulate both estrogen ... be partially blocked by 17β-estradiol (E2), suggesting RTV acts as an antagonist for E2. Computational modeling ...
Tópico(s): Cholesterol and Lipid Metabolism
2014 - Elsevier BV | Experimental Cell Research
Andrieke J. A. M. Thissen, Marjolein Luman, Catharina A. Hartman, Pieter J. Hoekstra, Marloes van Lieshout, Barbara Franke, Jaap Oosterlaan, Nanda Rommelse, Jan K. Buitelaar,
... in decreased accuracy and increased reaction time variability (RTV). It is not known whether motor timing impairments ... neurocognitive measures included RT median (RTM: representing accuracy), RTV and ex-Gaussian component τ (τ: representing infrequent ... Results Unaffected children from families with ADHD had RTV (but not RTM or τ) scores in between ... unaffected parents of families with ADHD showed increased RTV compared to controls, regardless of age (not significant ... IQ). There were indications for shared familiality between RTV and ADHD as reflected by sibling cross-correlations ...
Tópico(s): Infant Development and Preterm Care
2014 - Elsevier BV | Journal of the American Academy of Child & Adolescent Psychiatry
Giuseppe Corona, Emanuela Vaccher, Michele Spina, Giuseppe Toffoli,
... of second-generation protease inhibitors, boosted with ritonavir (Rtv), which is one of the most important inhibitors ... parameters. During the co-administration of atazanavir (ATV)/Rtv 300/100 mg (q24 h) and darunavir (DRV)/Rtv 600/100 mg (q24 h) in case 1 ... indicates that ATV and DRV in association with Rtv effectively influence the pharmacokinetic profile of VBL by ... VBL was given in conjunction with lopinavr (LPV)/Rtv (Fig. 1). In these patients, the VBL AUC ... higher than that observed in patients receiving ATV/Rtv and DRV/Rtv. After the ABVD administration, the ...
Tópico(s): Viral-associated cancers and disorders
2013 - Lippincott Williams & Wilkins | AIDS