... Silvia M. Kreda, Natacha Steinckwich-Besancon, Hong Dang, Rafael García-Mata, T. Kendall Harden, and Eduardo R. Lazarowski1 September ...
Tópico(s): Receptor Mechanisms and Signaling
2012 - American Physical Society | AJP Cell Physiology
Juan Cueva, Silvia Antolín, Lourdes Calvo, Isaura Fernández, Manuel Ramos, Lucía Paz, Jesús García Mata, Rafael López‐López, Manuel Constenla, Eva Pérez, Ana González, María Luz Pellón, S. Varela, Teresa López‐Fernández,
This Galician consensus statement is a joint oncologists/cardiologists initiative indented to establish basic recommendations on how to prevent and to manage the cardiotoxicity in breast cancer with the aim of ensuring an optimal cardiovascular care of these patients. A clinical screening of the patients before treatment is recommended to stratify them into a determined risk group based on their intrinsic cardiovascular risk factors and those extrinsic arose from breast cancer therapy, thereby providing ...
Tópico(s): Cardiac Imaging and Diagnostics
2017 - Springer Science+Business Media | Clinical & Translational Oncology
Javier López Jiménez, María Isabel Clemente, Nick Weber, Javier Cabello Sánchez, Paula Ortega, F. Javier de la Mata, Rafael Gómez, Dolores García, Luis A. López‐Fernández, María Ángeles Muñoz‐Fernández,
Tópico(s): HIV Research and Treatment
2010 - Adis, Springer Healthcare | BioDrugs
Francisco González‐Vílchez, José Ayuela, Miguel Ares, Nuria Sánchez Mata, Amparo García González, Rafael Martín Durán,
Abstract To overcome the limitations of mitral inflow parameters for predicting pulmonary capillary wedge pressure (PCWP), combined indices (with Doppler tissue imaging or color M-mode Doppler) have been developed. This study was aimed to compare the accuracy of these indices to predict PCWP. Sixty-one patients were studied. The best correlations with PCWP were found for indices that combined isovolumic relaxation time with flow propagation velocity (color M-mode) or early diastolic velocity of the lateral ...
Tópico(s): Pulmonary Hypertension Research and Treatments
2002 - Elsevier BV | Journal of the American Society of Echocardiography
... Vacas-Córdoba, Núria Climent, Francisco J De La Mata, Montserrat Plana, Rafael Gómez, Marjorie Pion, Felipe García & Maria Ángeles Muñoz-Fernández22 December 2014 | Nanomedicine, Vol. ...
Tópico(s): Immune Cell Function and Interaction
2012 - Future Medicine | Immunotherapy
Massimo Bogliolo, Roser Pujol, Miriam Aza‐Carmona, Núria Muñoz-Subirana, Benjamín Rodríguez‐Santiago, José Antonio Casado, Paula Rı́o, Christopher Bauser, Judith Reina-Castillón, Marcos López‐Sánchez, Lidia González‐Quereda, P. Gallano, Albert Catalá, Ana Ruiz-Llobet, Isabel Badell, Cristina Díaz de Heredia, Raquel Hladun, Leonort Senent, Bienvenida Argilés, Juan Bergua, Fatima Bañez, Beatriz Arrizabalaga, Ricardo López Almaraz, Monica López, Á Figuera, Antonio Molinés, Inmaculada Pérez de Soto, Inés Hernando, Juan Antonio Muñoz, Maria Marín, Judith Balmañà, Neda Stjepanovic, Estela Carrasco, Isabel Cuesta, José Miguel Cosuelo, Alexandra Regueiro, José M. Moraleda, Ana Maria Galera-Miñarro, Laura Rosiñol, Ana Carrió, Cristina Beléndez‐Bieler, Antonio Escudero Soto, Elena Cela, Gregorio de la Mata, Rafael Fernández‐Delgado, Maria Carmen Garcia-Pardos, Raquel Sáez-Villaverde, Marta Barragaño, Raquel Portugal, Francisco Lendínez, Ines Hernadez, José Manue Vagace, Maria C. Tapia, J. M. Nieto, Marta Garcia, M J Garcia Gonzalez, Cristina Vicho, Eva Heredero Gálvez, Alberto Valiente, María Luisa Antelo, Phil Ancliff, Francisco García‐García, Joaquı́n Dopazo, Julián Sevilla, Tobias Paprotka, Luis A. Pérez‐Jurado, Juan A. Bueren, Jordi Surrallés,
Purpose Patients with Fanconi anaemia (FA), a rare DNA repair genetic disease, exhibit chromosome fragility, bone marrow failure, malformations and cancer susceptibility. FA molecular diagnosis is challenging since FA is caused by point mutations and large deletions in 22 genes following three heritability patterns. To optimise FA patients’ characterisation, we developed a simplified but effective methodology based on whole exome sequencing (WES) and functional studies. Methods 68 patients with FA ...
Tópico(s): Chromosomal and Genetic Variations
2019 - BMJ | Journal of Medical Genetics
Carlos Muñoz Palza, Álvaro Cordero Jiménez, Rafael Tenor-Serrano, Rafael García Mata, Purificación Contreras Molina, Isabel García Muñoz,
Evaluar la eficacia de la citología por punción aspiración con aguja fina (PAAF) en el diagnóstico de malignidad de los tumores de la glándula parótida con el fin de planificar el tratamiento más adecuado para cada caso. Se realiza un estudio retrospectivo en una muestra de 41 pacientes, en el que se evalúa la correlación entre la PAAF y los hallazgos histopatológicos de la pieza quirúrgica de los tumores de la glándula parótida, realizadas entre los años 2004 y 2008. La sensibilidad de la PAAF para ...
Tópico(s): Neurofibromatosis and Schwannoma Cases
2010 - Elsevier BV | Acta Otorrinolaringológica Española
Laura Forcano, Fernanda Mata, Rafael de la Torre, Antonio Verdejo‐García,
We systematically reviewed research on cognitive training and neuromodulation interventions for reducing food craving/intake, unhealthy diet and weight, and discussed their mechanisms of action. We reviewed 50 studies involving six cognitive trainings: Approach and Attentional Bias Modification, Implementation Intentions, Response Inhibition, Episodic Future Thinking and Working Memory; and four neuromodulation approaches: Transcranial Magnetic Stimulation (TMS), transcranial Direct Current Stimulation ( ...
Tópico(s): Neural and Behavioral Psychology Studies
2018 - Elsevier BV | Neuroscience & Biobehavioral Reviews
Rafael Gras, Miguel Relloso, María I. García, F. Javier de la Mata, Rafael Gómez, Luis A. López‐Fernández, María Ángeles Muñoz‐Fernández,
We evaluated the 2G-NN16-carbosilane dendrimer activities in Th17 response as a potential therapy for Th17 deregulated pathologies. IL17A, IL17F, IL22, IL23 and other interleukins secreted by Th17 cells CD4+ cells were down regulated when cells were cultured in the presence of this dendrimer. Furthermore, IL17F and IL17A protein levels in splenocytes from mice pretreated with 2G-NN16 dendrimer in a Th17 induction mouse model were lower than those corresponding to PBS treated mice. Treatment of mice ...
Tópico(s): Psoriasis: Treatment and Pathogenesis
2012 - Elsevier BV | Biomaterials
Estefanía González-García, Marek Malý, F. Javier de la Mata, Rafael Gómez, Marı́a Luisa Marina, María Concepción García,
Tópico(s): Click Chemistry and Applications
2016 - Elsevier BV | Colloids and Surfaces B Biointerfaces
Gustavo Resler, Renée Lavie, Julio Campos, Salvador Mata, Mary Urbina, A. García, Rafael Apitz, Lucimey Lima,
<i>Objective(s):</i> Folic acid, a micronutrient supporting the natural defense system, may elevate antidepressant responses, although the lymphocyte serotonergic system has not been explored in folate-supplemented depressed patients. <i>Methods:</i> Twenty-seven patients were randomly assigned to groups receiving fluoxetine (20 mg) and folic acid (10 mg/day) or fluoxetine and placebo for 6 weeks. Clinical outcome was assessed according to the Hamilton Depression Rating Scale (HDRS) ...
Tópico(s): Maternal Mental Health During Pregnancy and Postpartum
2008 - Karger Publishers | NeuroImmunoModulation
María Ángeles Muñoz‐Fernández, Rafael Ceña-Díez, Pilar García Broncano, F. Javier de la Mata, Rafael Gómez,
The development of a safe and effective microbicide to prevent the sexual transmission of human immunodeficiency virus (HIV)-1 is urgently needed. Unfortunately, the majority of microbicides, such as poly(L-lysine)-dendrimers, anionic polymers, or antiretrovirals, have proved inactive or even increased the risk of HIV infection in clinical trials, most probably due to the fact that these compounds failed to prevent semen-exposed HIV infection. We showed that G2-S16 dendrimer exerts anti-HIV-1 activity ...
Tópico(s): Advanced biosensing and bioanalysis techniques
2016 - Dove Medical Press | International Journal of Nanomedicine
Rafael Ceña-Díez, Pilar García‐Broncano, F. Javier de la Mata, Rafael Gómez, Salvador Resino, María Ángeles Muñoz‐Fernández,
Unprotected heterosexual intercourse is the first route for sustaining the global spread of human immunodeficiency virus type 1 (HIV-1), being responsible for 80% of new HIV-1 infections in the world.
Tópico(s): Virology and Viral Diseases
2017 - Royal Society of Chemistry | Nanoscale
María Ángeles Muñoz‐Fernández, Rafael Ceña-Díez, Enrique Vacas‐Córdoba, Pilar García Broncano, F. Javier de la Mata, Rafael Gómez, Marek Malý,
Abstract: Topical microbicides to stop sexually transmitted diseases, such as herpes simplex virus type 2 (HSV-2), are urgently needed. The emerging field of nanotechnology offers novel suitable tools for addressing this challenge. Our objective was to study, in vitro and in vivo, antiherpetic effect and antiviral mechanisms of several polyanionic carbosilane dendrimers with anti-HIV-1 activity to establish new potential microbicide candidates against sexually transmitted diseases. Plaque reduction ...
Tópico(s): Virology and Viral Diseases
2016 - Dove Medical Press | International Journal of Nanomedicine
Marı́a Casares-Jiménez, Tránsito García‐García, José M. Suárez-Cárdenas, Ana Belén Pérez, M.A. Martı́n, Javier Caballero‐Gómez, Carmen Michán, Diana Corona‐Mata, María Á. Risalde, Ignacio Valero, Rafael Guerra, Ignacio García‐Bocanegra, Antonio Rivero, Antonio Rivero‐Juárez, Juan J. Garrido,
Wastewater pathogen monitoring is useful for surveillance of enteric pathogens. Information about the presence of Paslahepevirus balayani (HEV) and emergent Rocahepevirus ratti (RHEV) in untreated water and their correlation with clinical cases is scarce. Aim To longitudinally monitor HEV and RHEV in wastewater and to evaluate their possible correlation with human cases.This study was carried out in the city of Cordoba (southern Spain) from March 2021 to March 2023. HEV and RHEV occurrence were evaluated ...
Tópico(s): Viral Infections and Immunology Research
2023 - Elsevier BV | The Science of The Total Environment
Felipe A. Calvo, Javier Serrano, Juan A. Díaz-González, M. Gómez-Espí, E. Bayo Lozano, Rafael Pérez García, Dolores de la Mata, José Ángel Arranz, Pilar García‐Alfonso, G. Pérez-Manga, E. Álvarez,
Purpose: To compare efficacy in terms of pathologic response in LARC patients treated with preoperative chemoradiation, with or without a short-intense course of induction oxaliplatin.Patients and Methods: From 05/98 to 10/02, 114 patients were treated with preoperative chemoradiation (4500–5040 cGy + oral Tegafur 1200 mg/day) for cT3-4N+/xM0 rectal cancer. Starting 05/01, 52 consecutive patients additionally received induction FOLFOX-4, oxaliplatin (85 mg/m2 iv d1), 5-FU (400 mg/m2 iv bolus d1) and ...
Tópico(s): Colorectal and Anal Carcinomas
2006 - Elsevier BV | Annals of Oncology
Enrique Vacas‐Córdoba, Núria Climent, F. Javier de la Mata, Montserrat Plana, Rafael Gómez, Marjorie Pion, Felipe García, María Ángeles Muñoz‐Fernández,
Although the antiretroviral therapy has led to a long-term control of HIV-1, it does not cure the disease. Therefore, several strategies are being explored to develop an effective HIV vaccine, such as the use of dendritic cells (DCs). DC-based immunotherapies bear different limitations, but one of the most critical point is the antigen loading into DCs. Nanotechnology offers new tools to overcome these constraints. Dendrimers have been proposed as carriers for targeted delivery of HIV antigens in ...
Tópico(s): HIV Research and Treatment
2014 - Future Medicine | Nanomedicine
Estefanía González-García, Marek Malý, F. Javier de la Mata, Rafael Gómez, Marı́a Luisa Marina, María Concepción García,
Tópico(s): Protein Structure and Dynamics
2016 - Springer Science+Business Media | Analytical and Bioanalytical Chemistry
Olalla Caseiro, Rocío Pérez‐Iglesias, Ignácio F. Mata, Obdulia Martínez‐García, José María Pelayo‐Terán, Rafael Tabarés‐Seisdedos, Víctor Ortiz‐García de la Foz, José Luis Vázquez‐Barquero, Benedicto Crespo‐Facorro,
Preventing relapse during the first years of illness has a critical impact on lifelong outcomes in schizophrenia. A better understanding and improvement in factors which influence relapse should diminish the risk of relapse and consequently improve the outcome of the illness. To identify factors associated with relapse after 3 years of a first episode in a sample of non-affective psychosis patients who are representative of clinical practice in an epidemiological catchment. We analyzed socio-demographic ...
Tópico(s): Bipolar Disorder and Treatment
2012 - Elsevier BV | Journal of Psychiatric Research
... Cosecha Mecánica del Algodon (Mechanical Harvesting of Cotton), Garcia Mata, Rafael, and Rómulo A. Franchelli. Ministerio de Agricultura, Junta ...
Tópico(s): Plant Virus Research Studies
1943 - Wiley | American Journal of Agricultural Economics
Rosa Zaragozá, Álvaro Gimeno Díaz de Atauri, Vicente J. Miralles, Elena R. García‐Trevijano, Rafael Carmena, Carlos J. Gómez‐García, Manuel Mata, Inmaculada R. Puertes, Luís Torres, Juan R. Viña,
Retinoic acid (RA) is a signaling molecule in the morphogenesis of the mammary gland, modulating the expression of matrix metalloproteinases (MMPs). The aim of this paper was to study the role of RA during weaning, which consists of three events: apoptosis of the secretory cells, degradation of the extracellular matrix, and adipogenesis. CRABP II and CRBP-1 carrier proteins increased significantly during weaning compared with lactating glands but reverted to control values after the litter resuckled. ...
Tópico(s): Antioxidant Activity and Oxidative Stress
2006 - American Physiological Society | AJP Endocrinology and Metabolism
Produção Nacional
Revisado por pares
Audrey Yule Coqueiro, Raquel Raizel, Andrea Bonvini, Thaís Menezes Hypólito, Allan da Mata Godois, Jéssica Aparecida da Silva Pereira, Amanda Garcia, Rafael Lara, Marcelo Macedo Rogero, Júlio Tirapegui,
Recent evidence suggests that increased brain serotonin synthesis impairs performance in high-intensity intermittent exercise and specific amino acids may modulate this condition, delaying fatigue. This study investigated the effects of glutamine and alanine supplementation on central fatigue markers in rats submitted to resistance training (RT). Wistar rats were distributed in: sedentary (SED), trained (CON), trained and supplemented with alanine (ALA), glutamine and alanine in their free form (G + A), ...
Tópico(s): Cardiovascular and exercise physiology
2018 - Multidisciplinary Digital Publishing Institute | Nutrients
F. Javier de la Mata, Rafael Gómez, Jesús Cano, Javier Sánchez‐Nieves, Paula Ortega, Sandra García‐Gallego,
Abstract Dendrimers are multifunctional molecules with well‐defined size and structure due to the step‐by‐step synthetic procedures required in their preparation. Dendritic constructs based on carbosilane scaffolds present carbon–carbon and carbon–silicon bonds, which results in stable, lipophilic, inert, and flexible structures. These properties are highly appreciated in different areas, including the pharmaceutical field, as they can increase the interaction with cell membranes and improve the ...
Tópico(s): Click Chemistry and Applications
2022 - Wiley | Wiley Interdisciplinary Reviews Nanomedicine and Nanobiotechnology
David Cabañero, Evelyne Célèrier, Paula García‐Nogales, Marina Mata, Bernárd P. Roques, Rafaël Maldonado, Margarita M. Puig,
The ultra-short-acting mu-opioid receptor (MOR) agonist remifentanil enhances postsurgical pain when used as main anesthetic in animal models and man. Although the mechanism/s involved are poorly characterized, changes in opioid receptor expression could be a relevant feature. Using a mouse model of postoperative pain, we assessed the expression of MOR and delta opioid receptors (DORs) and the efficacy of Herpes Simplex vector-mediated proenkephalin release (SHPE) preventing postoperative nociceptive ...
Tópico(s): Neuropeptides and Animal Physiology
2008 - Lippincott Williams & Wilkins | Pain
Cristina Montealegre, Beatriz Rasines, Rafael Gómez, F. Javier de la Mata, Carmen García‐Ruiz, Marı́a Luisa Marina,
Protein profiles are becoming an important tool to differentiate and classify varieties of several cultivars and to obtain a specific fingerprint for them. The use of protein profiles for these purposes needs to achieve high separation efficiencies to obtain a high number of well resolved peaks. In this work, carbosilane dendrimers with interior carbon-silicon bonds and negatively charged in the dendrimer surface with carboxylic acid as functional groups were employed as nanoadditives to separate ...
Tópico(s): Microfluidic and Capillary Electrophoresis Applications
2012 - Elsevier BV | Journal of Chromatography A
Trinidad Mata Balaguer, Ángeles Gómez‐Martínez, Pilar García-Morales, Javier Lacueva, Rafael Calpena, Lourdes Rocamora‐Reverte, Natividad López, Isabel Martínez-Lacaci, José A. Ferragut, Miguel Saceda,
Abstract Background It has been reported that the histone deacetylase inhibitor (iHDAc) trichostatin A (TSA) induces an increase in MDR1 gene transcription (ABCB1). This result would compromise the use of iHDACs in combination with other cytotoxic agents that are substrates of P-glycoprotein (Pgp). It has also been reported the use of alternative promoters by the ABCB1 gene and the existence of a translational control of Pgp protein. Finally, the ABCB1 gene is located in a genetic locus with the nested ...
Tópico(s): Epigenetics and DNA Methylation
2012 - Springer Science+Business Media | BMC Molecular Biology
Marta Maroto-Díaz, Natalia Sanz del Olmo, Laura Muñoz‐Moreno, Ana M. Bajo, Marı́a J. Carmena, Rafael Gómez, Sandra García‐Gallego, F. Javier de la Mata,
Prostate cancer is the fifth cause of death among men worldwide. Patients suffering resistant prostate tumor, unresponsive to common treatments, can only be treated with palliative therapy. Ruthenium(II) carbosilane metallodendrimers containing arene moieties were evaluated as a novel antitumor nanotherapy against resistant prostate cancer. The preclinical evaluation included relevant in vitro, ex vivo and in vivo assays, in an experimental mice model of human prostate cancer. Promising cytotoxic, ...
Tópico(s): Ferrocene Chemistry and Applications
2019 - Elsevier BV | European Polymer Journal
Helena Aguilar, Ander Urruticoechea, Pasi Halonen, Kazuma Kiyotani, Taisei Mushiroda, Xavier Barril, Jordi Serra-Musach, Abul Bashar Mir Md. Khademul Islam, Livia Caizzi, Luciano Di Croce, Ekaterina Nevedomskaya, Wilbert Zwart, Josefine Bostner, Elin Karlsson, G. Pérez Tenorio, Tommy� Fornander, Dennis C. Sgroi, Rafael Garcı́a-Mata, Maurice P.H.M. Jansen, Nadia García, Núria Bonifaci, Fina Climent, María Teresa Soler, Alejo Rodríguez‐Vida, Miguel Ángel Cobos Gil, Joan Brunet, Griselda Martrat, Laia Gómez‐Baldó, Ana I. Extremera, Albert Figueras, Josep Balart, Robert Clarke, Kerry L. Burnstein, Kathryn E. Carlson, John A. Katzenellenbogen, Miguel Vizoso, Manel Esteller, Alberto Villanueva, Ana B. Rodríguez-Peña, Xosé R. Bustelo, Yusuke Nakamura, Hitoshi Zembutsu, Olle Stål, Roderick L. Beijersbergen, Miguel Ángel Pujana,
Abstract Introduction Endocrine therapies targeting cell proliferation and survival mediated by estrogen receptor α (ERα) are among the most effective systemic treatments for ERα-positive breast cancer. However, most tumors initially responsive to these therapies acquire resistance through mechanisms that involve ERα transcriptional regulatory plasticity. Herein we identify VAV3 as a critical component in this process. Methods A cell-based chemical compound screen was carried out to identify therapeutic ...
Tópico(s): Cancer-related gene regulation
2014 - BioMed Central | Breast Cancer Research
Marjorie Pion, Maria Jesús Serramía, Laura Díaz, Maria Bryszewska, Teresa Gallart, Felipe García, Rafael Gómez, F. Javier de la Mata, María Ángeles Muñoz‐Fernández,
Dendritic cells (DCs) play a major role in development of cell-mediated immunotherapy due to their unique role in linking innate and adaptive immunities. In spite of improvement in this area, strategies employing ex vivo generated DCs have shown limited efficacy in clinical trials. Dendrimers have been proposed as new carriers for drug delivery in aim to ameliorate DCs antigen loading that is a pivotal point in DCs approaches. In this study, we have investigated the phenotypic and functional characteristics ...
Tópico(s): Dendrimers and Hyperbranched Polymers
2010 - Elsevier BV | Biomaterials
Rosa Ayesa‐Arriola, Rocío Pérez‐Iglesias, José Manuel Rodríguez-Sánchez, Ignácio F. Mata, Elsa Gómez-Ruíz, María Teresa García‐Unzueta, Obdulia Martínez‐García, Rafael Tabarés‐Seisdedos, José Luis Vázquez‐Barquero, Benedicto Crespo‐Facorro,
Tópico(s): Gastroesophageal reflux and treatments
2012 - Springer Science+Business Media | European Archives of Psychiatry and Clinical Neuroscience