R. Rask‐Nielsen, Erik Andreasen,
... INVESTIGATIONS INTO THE GROWTH OF NORMAL THYMIC TISSUE1 Ragna Rask-Nielsen, Ragna Rask-Nielsen INSTITUTE OF BIOCHEMISTRY (CHIEF: RICH. EGE. PH.D.) ... OF COPENHAGENSearch for more papers by this author Ragna Rask-Nielsen, Ragna Rask-Nielsen INSTITUTE OF BIOCHEMISTRY (CHIEF: RICH. EGE. PH.D.) ...
Tópico(s): Science and Climate Studies
1955 - Wiley | Acta Pathologica Microbiologica Scandinavica
... plasma-cell neoplasia in a strain of mice Ragna Rask-Nielsen Ph.D., Ragna Rask-Nielsen Ph.D. Fibiger Laboratory at the University Institute ... Copenhagen, DenmarkSearch for more papers by this author Ragna Rask-Nielsen Ph.D., Ragna Rask-Nielsen Ph.D. Fibiger Laboratory at the University Institute ...
Tópico(s): Virus-based gene therapy research
1951 - Wiley | Cancer
Joseph G. Tully, R. Rask‐Nielsen,
... for more papers by this authorRagna Rask-Nielsen, Ragna Rask-Nielsen Laboratory of Bacterial Diseases National Institute of Allergy ... for more papers by this authorRagna Rask-Nielsen, Ragna Rask-Nielsen Laboratory of Bacterial Diseases National Institute of Allergy ...
Tópico(s): Plant Virus Research Studies
1967 - Wiley | Annals of the New York Academy of Sciences
Ragna Berthelsen, Carsten Uhd Nielsen, Birger Brodin,
Transepithelial di/tripeptide transport in enterocytes occurs via the apical proton-coupled peptide transporter, hPEPT1 (SLC15A1) and a basolateral peptide transporter, which has only been characterized functionally. In this study we examined the pH dependency, substrate uptake kinetics and substrate specificity of the transporter.We studied the uptake of [(14) C]Gly-Sar from basolateral solution into Caco-2 cell monolayers grown for 17-22 days on permeable supports, at a range of basolateral pH values. ...
Tópico(s): Amino Acid Enzymes and Metabolism
2013 - Oxford University Press | Journal of Pharmacy and Pharmacology
Helle V. Petersen, Mette C. Jørgensen, Frank G. Andersen, Jan Jensen, Tove F-Nielsen, Ragna Jørgensen, Ole Madsen, Palle Serup,
Tópico(s): Diabetes and associated disorders
2000 - Academic Press | Molecular Cell Biology Research Communications
Lucrezia Caselli, Tanja Traini, Samantha Micciulla, Federica Sebastiani, Sebastian Köhler, Emilie Marie Nielsen, Ragna Guldsmed Diedrichsen, Maximilian W. A. Skoda, Martin Malmsten,
Abstract This study explores the coating of photocatalytic nanoparticles with antimicrobial peptides (AMPs) for boosted antimicrobial effects, and how such effects depend on AMP properties. For this, TiO 2 nanoparticles are coated with the AMP KYE21 or its hydrophobically enhanced variant WWWKYE21. Mirroring effects of free peptides, coated nanoparticles displayed higher binding and UV‐induced degradation for bacteria‐like than for mammalian‐like membranes. In addition, they degraded bacterial lipopolysaccharides ( ...
Tópico(s): Silk-based biomaterials and applications
2024 - Wiley | Advanced Functional Materials
A. J. F. Coimbra, Jordi Rimola, Míriam Cuatrecasas, Gert De Hertogh, Gert Van Assche, Ragna Vanslembrouck, Henning Glerup, Agnete Nielsen, Rikke Hagemann‐Madsen, Yoram Bouhnik, Magaly Zappa, Dominique Cazals–Hatem, Geert R. D’Haens, Jaap Stoker, Sybren L. Meijer, Gerhard Rogler, Andreas Boss, Achim Weber, Rui Zhao, Mary E. Keir, Alexis Scherl, Alex de Crespigny, Timothy T. Lu, Julián Panés,
INTRODUCTION: Magnetic resonance enterography (MRE) is useful for detecting bowel strictures, whereas a number of imaging biomarkers may reflect severity of fibrosis burden in Crohn's disease (CD). This study aimed to verify the association of MRE metrics with histologic fibrosis independent of inflammation. METHODS: This prospective European multicenter study performed MRE imaging on 60 patients with CD with bowel strictures before surgical resection. Locations of 61 histological samples were annotated ...
Tópico(s): Diverticular Disease and Complications
2022 - Lippincott Williams & Wilkins | Clinical and Translational Gastroenterology
R. Rask‐Nielsen, Georg Hogreffe,
... AND IN MICE OF THE F1 CROSS BREEDINGS1 RAGNA RASK-NIELSEN, RAGNA RASK-NIELSEN UNIVERSITY INSTITUTE OF BIOCHEMISTRY AND THE UNIVERSITY INSTITUTE ... GENETICS, COPENHAGENSearch for more papers by this author RAGNA RASK-NIELSEN, RAGNA RASK-NIELSEN UNIVERSITY INSTITUTE OF BIOCHEMISTRY AND THE UNIVERSITY INSTITUTE ...
Tópico(s): CRISPR and Genetic Engineering
1953 - Wiley | Acta Pathologica Microbiologica Scandinavica
Mie Kristensen, Ragna Guldsmed Diedrichsen, Valeria Vetri, Vito Foderà, Hanne Mørck Nielsen,
Oral delivery of therapeutic peptides is hampered by their large molecular size and labile nature, thus limiting their permeation across the intestinal epithelium. Promising approaches to overcome the latter include co-administration with carrier peptides. In this study, the cell-penetrating peptide penetratin was employed to investigate effects of co-administration with insulin and the pharmacologically active part of parathyroid hormone (PTH(1-34)) at pH 5, 6.5, and 7.4 with respect to complexation, ...
Tópico(s): Advanced biosensing and bioanalysis techniques
2020 - Multidisciplinary Digital Publishing Institute | Pharmaceutics
Ditlev Birch, Ragna Guldsmed Diedrichsen, Philip C. Christophersen, Huiling Mu, Hanne Mørck Nielsen,
The absence of a surface-lining mucus layer is a major pitfall for the Caco-2 epithelial model. However, this limitation can be alleviated by applying biosimilar mucus (BM) to the apical surface of the cell monolayer, thereby constructing a mucosa mimicking in vivo conditions. This study aims to elucidate the influence of BM as a barrier towards exogenic compounds such as permeation enhancers, and components of fed state simulated intestinal fluid (FeSSIF). Caco-2 cell monolayers surface-lined with ...
Tópico(s): Inhalation and Respiratory Drug Delivery
2018 - Elsevier BV | European Journal of Pharmaceutical Sciences
... s history are the subject of this article. Ragna Nielsen, a teacher and an amateur historian, in 1904 ...
Tópico(s): Gender Politics and Representation
2007 - Wiley | Gender & History
Sigurður Júlíusson, Jon Kristinn Nielsen, Valgerður Rúnarsdóttir, Ingunn Hansdóttir, Ragna Sigurdardóttir, Einar S. Björnsson,
To examine lifetime drinking patterns in men and women with alcohol-induced pancreatitis (AIP) in comparison with patients with alcoholic use disorder (AUD) without pancreatic disease.Alcohol consumption patterns were assessed using a validated questionnaire, the Lifetime Drinking History (LDH), during an outpatient visit. Patients diagnosed with AIP were matched for gender and age (+/- 5 years) with patients with AUD in addiction treatment.A total of 45 patients with AIP (35 males, 10 females) and 45 AUD ...
Tópico(s): Alcohol Consumption and Health Effects
2018 - Taylor & Francis | Scandinavian Journal of Gastroenterology
Ragna Guldsmed Diedrichsen, Stine Harloff‐Helleberg, Werner Ulrich, Melissa Besenius, Ekkehard Leberer, Mie Kristensen, Hanne Mørck Nielsen,
Delivery of therapeutic peptides upon oral administration is highly desired and investigations report that the cell-penetrating peptide (CPP) penetratin and its analogues shuffle and penetramax show potential as carriers to enhance insulin delivery. Exploring this, the specific aim of the present study was to understand the impact that their complexation with a lipidated or non-lipidated therapeutic cargo would have on the delivery, to evaluate the effect of differences in membrane interactions in ...
Tópico(s): Antimicrobial Peptides and Activities
2021 - Elsevier BV | Journal of Controlled Release
Mathias Uhlén, Max Karlsson, Andreas Hober, Anne-Sophie Svensson, Julia Scheffel, David Kotol, Wen Zhong, Abdellah Tebani, Linnéa Strandberg, Fredrik Edfors, Evelina Sjöstedt, Jan Mulder, Adil Mardinoğlu, Anna Berling, Siri Ekblad, Melanie Dannemeyer, Sara Kanje, Johan Rockberg, Magnus Lundqvist, Magdalena Malm, Anna-Luisa Volk, Peter Nilsson, Anna Månberg, Tea Dodig‐Crnković, Elisa Pin, Martin Zwahlen, Per Oksvold, Kalle von Feilitzen, Ragna S. Häussler, Mun‐Gwan Hong, Cecilia Lindskog, Fredrik Pontén, Borbala Katona, Jimmy Vuu, Emil Lindström, Jens Nielsen, Jonathan L. Robinson, Burcu Ayoglu, Diana Mahdessian, Devin P. Sullivan, Peter Thul, Frida Danielsson, Charlotte Stadler, Emma Lundberg, Göran Bergström, Anders Gummesson, Bjørn G. Voldborg, Hanna Tegel, Sophia Hober, Björn Forsström, Jochen M. Schwenk, Linn Fagerberg, Åsa Sivertsson,
A database provides information on the relative abundances and locations of human proteins that are predicted to be secreted.
Tópico(s): Bioinformatics and Genomic Networks
2019 - American Association for the Advancement of Science | Science Signaling
Jon Kristinn Nielsen, Sigurður Ólafsson, Ottar M. Bergmann, Valgerður Rúnarsdóttir, Ingunn Hansdóttir, Ragna Sigurdardóttir, Einar S. Björnsson,
Objective: To determine the differences in lifetime alcohol intake (LAI) and drinking patterns between patients with alcoholic liver disease (ALD) and alcohol use disorder (AUD) without notable liver injury and between males and females with ALD.Methods: Alcohol drinking patterns were assessed using the Lifetime Drinking History (LDH) a validated questionnaire, during an outpatient visit. Patients with AUD, currently in addiction treatment, were matched for gender and age (±5 years) with the ALD group. ...
Tópico(s): Liver Disease and Transplantation
2017 - Taylor & Francis | Scandinavian Journal of Gastroenterology
... org/10.1177/0269094218802987Arndis Vilhjalmsdottir, Jon Gunnar Bernburg, Ragna B. Gardarsdottir, Inga Dora Sigfusdottir Community income inequality and adolescent emotional problems: A population-based study, Journal of Community Psychology 46, no.66 (Mar 2018): 715–733.https://doi.org/10.1002/jcop.21968Lasse Nielsen What Is Our Real Concern with Real Inequality?, ...
Tópico(s): Ethics in medical practice
1987 - University of Chicago Press | Ethics
Ragna Guldsmed Diedrichsen, Pernille Sønderby Tuelung, Vito Foderà, Hanne Mørck Nielsen,
The inherent low oral bioavailability of therapeutic peptides can be enhanced by the cell-penetrating peptide penetratin and its analogues shuffle and penetramax applied as carriers for delivery of insulin. In this study, the objective was to gain mechanistic insights on the effect of the carrier peptide stereochemistry on their interactions with insulin and on insulin delivery. Insulin-carrier peptide interactions were investigated using small-angle X-ray scattering and cryogenic transmission electron ...
Tópico(s): Monoclonal and Polyclonal Antibodies Research
2023 - American Chemical Society | Molecular Pharmaceutics
Ragna Guldsmed Diedrichsen, Valeria Vetri, Sylvain Prévost, Vito Foderà, Hanne Mørck Nielsen,
The cell-penetrating peptide penetratin and its analogues shuffle and penetramax have been used as carrier peptides for oral delivery of therapeutic peptides such as insulin. Their mechanism of action for this purpose is not fully understood but is believed to depend on the interactions of the peptide with the cell membrane. In the present study, peptide-liposome interactions were investigated using advanced biophysical techniques including small-angle neutron scattering and fluorescence lifetime ...
Tópico(s): Lipid Membrane Structure and Behavior
2023 - Elsevier BV | Journal of Colloid and Interface Science
Danai-Anastasia Panou, Ragna Guldsmed Diedrichsen, Mie Kristensen, Hanne Mørck Nielsen,
This chapter describes the use of cell-penetrating peptides (CPPs) as carriers for transepithelial delivery of therapeutic peptides. Assessment of transepithelial peptide permeation and the mechanisms of action that permeability enhancing drug carriers exert on the epithelium requires subtle sample preparation and analysis by orthogonal methods. Here, the preparation and use of CPP-insulin physical mixture samples including the quantification of insulin by enzyme-linked immunosorbent assay (ELISA) ...
Tópico(s): Advanced Drug Delivery Systems
2021 - Springer Science+Business Media | Methods in molecular biology
H. Wilman, Constantinos A. Parisinos, Naeimeh Atabaki‐Pasdar, Matt Kelly, E. Louise Thomas, Stefan Neubauer, Anubha Mahajan, Aroon D. Hingorani, Riyaz Patel, Harry Hemingway, Paul W. Franks, Jimmy D. Bell, Rajarshi Banerjee, Hanieh Yaghootkar, Christopher Jennison, Beate Ehrhardt, Patrick Baum, Corinna Schoelsch, Jan Freijer, Rolf Grempler, Ulrike Graefe‐Mody, Anita M. Hennige, Christiane Dings, Thorsten Lehr, Nina Scherer, Iryna Sihinecich, François Pattou, Violeta Raverdi, Robert Caïazzo, F. Torres, Hélène Verkindt, Andrea Mari, Andrea Tura, Toni Giorgino, Roberto Bizzotto, Philippe Froguel, Amelie Bonneford, Mickaël Canouil, Véronique Dhennin, Caroline Brorsson, Søren Brunak, Federico De Masi, Valborg Guðmundsdóttir, Helle K. Pedersen, Karina Banasik, Cecilia Engel Thomas, Peter Wad Sackett, Hans‐Henrik Stærfeldt, Agnete Troen Lundgaard, Birgitte Nilsson, Agnes Nielsen, Gianluca Mazzoni, Tugce Karaderi, Simon Rasmussen, Joachim Johansen, Rosa Lundbye Allesøe, Andreas Fritsche, Barbara Thorand, Jerzy Adamski, Harald Grallert, Mark Haid, Sapna Sharma, Martina Troll, Jonathan Adam, Jorge Ferrer, Heather Eriksen, Gary Frost, Ragna S. Häussler, Mun‐Gwan Hong, Jochen M. Schwenk, Mathias Uhlén, Claudia Nicolay, Imre Pávó, Birgit Steckel-Hamann, Melissa K. Thomas, Kofi Adragni, Han Wu, Leen't Hart, Slieker Roderick, Nienke van Leeuwen, Koen F. Dekkers, Francesca Frau, Johann Gassenhuber, Bernd Jablonka, Petra Musholt, Hartmut Ruetten, J. Tillner, Tania Baltauss, Oana Bernard Poenaru, Nathalie de Préville, Marianne Rodriquez, Manimozhiyan Arumugam, Kristine H. Allin, Line Engelbrechtsen, Torben Hansen, Tue H. Hansen, Annemette Forman, Anna Jonsson, Oluf Pedersen, Avirup Dutta, Josef Korbinian Vogt, Henrik Vestergaard, Markku Laakso, Tarja Kokkola, Teemu Kuulasmaa, Paul W. Franks, Nick N. Giordano, Hugo Pomares‐Millan, Hugo Fitipaldi, Pascal M. Mutie, Maria Klintenberg, Margit Bergstrom, Per‐Henrik Groop, Martin Ridderstråle, Naeimeh Atabaki Pasdar, Harshal Deshmukh, Alison Heggie, Dianne Wake, Donna McEvoy, Ian McVittie, Mark Walker, Andrew T. Hattersley, Anita Hill, Angus G. Jones, Timothy J. McDonald, Mandy H. Perry, Rachel Nice, Michelle Hudson, Claire E. Thorne, Emmanouil T. Dermitzakis, Ana Viñuela, Louise Cabrelli, Heather Loftus, Adem Y. Dawed, Louise A. Donnelly, Ian Forgie, Ewan R. Pearson, Nicholette D. Palmer, Andrew Brown, Robert W. Koivula, Agata Wesolowska‐Andersen, Moustafa Abdalla, Nicky McRobert, Juan Fernandez, Yunlong Jiao, Neil Robertson, Stephen Gough, Jane Kaye, Miranda Mourby, Anubha Mahajan, Mark I. McCarthy, Nisha Shah, Harriet Teare, Reinhard W. Holl, Anitra D.M. Koopman, Femke Rutters, Joline W. J. Beulens, Lenka Groeneveld, Anitra D.M. Koopman, Jimmy D. Bell, E. Louise Thomas, Brandon Whitcher,
Excess liver iron content is common and is linked to the risk of hepatic and extrahepatic diseases. We aimed to identify genetic variants influencing liver iron content and use genetics to understand its link to other traits and diseases.
Tópico(s): Folate and B Vitamins Research
2019 - Elsevier BV | Journal of Hepatology
Adem Y. Dawed, Kaixin Zhou, Nienke van Leeuwen, Anubha Mahajan, Neil Robertson, Robert W. Koivula, Petra J. M. Elders, Simone P. Rauh, Angus G. Jones, Reinhard W. Holl, Julia C. Stingl, Paul W. Franks, Mark I. McCarthy, Leen M. ‘t Hart, Ewan R. Pearson, Christopher Jennison, Beate Ehrhardt, Patrick Baum, Corinna Schoelsch, Jan Freijer, Rolf Grempler, Ulrike Graefe‐Mody, Anita M. Hennige, Christiane Dings, Thorsten Lehr, N. Scherer, Iryna Sihinecich, François Pattou, V. Raverdi, Robert Caïazzo, F. Torres, Hélène Verkindt, Andrea Mari, Andrea Tura, Toni Giorgino, Roberto Bizzotto, Philippe Froguel, Amelie Bonneford, Mickaël Canouil, Véronique Dhennin, Caroline Brorsson, Søren Brunak, Francesco De Masi, V. Gudmundsdóttir, Hans Kristian Pedersen, K. Banasik, E. S. Thomas, Walter G. Sackett, Hans‐Henrik Stærfeldt, Agnete Troen Lundgaard, Birgitte Nilsson, Nielsen Am, Gianluca Mazzoni, Tugce Karaderi, Simon Rasmussen, Joachim Johansen, Rosa Lundbye Allesøe, A. Fritsche, Barbara Thorand, Jerzy Adamski, H. Grallert, Mark Haid, Sapna Sharma, Mark Troll, Jean‐Michel Adam, Jorge Ferrer, Philippe Froguel, R.G. Eriksen, Gary Frost, Ragna S. Häussler, Mun‐Gwan Hong, Jochen M. Schwenk, Mathias Uhlén, CLAUDIA NICOLAY, Imre Pávó, Birgit Steckel-Hamann, Melissa K. Thomas, Kofi P. Adragni, Huihai Wu, Leen M. ‘t Hart, Ryland Roderick, Nienke van Leeuwen, Koen F. Dekkers, Francesca Frau, Johann Gassenhuber, Bernd Jablonka, PB Musholt, Hartmut Ruetten, J. Tillner, Tania Baltauss, Olivier Bernard, N. Poenaru, Michel Préville, M. Rodriquez, Kumar Arumugam, Leslie Allin, T. Engelbrechtsen, Tue H. Hansen, Anne-Louise S. Hansen, Axel Forman, Olof Jonsson, Anette Fischer Pedersen, JK Dutta, H.‐J. Vogt, Mogens Vestergaard, Teemu Laakso, Tarja Kokkola, P.W. Kuulasmaa, G.N. Franks, Heidi Giordano, Hugo Pomares‐Millan, P. Fitipaldi, M. Mutie, Maria Klintenberg, Lea Bergström, M. Groop, N. Ridderstrale, Homayoon Pasdar, Abhishek Deshmukh, D. Heggie, Deborah J. Wake, I. McEvoy, M. McVittie, A.T. Walker, Andrew T. Hattersley, Andrew G. Hill, T.J. Jones, Timothy J. McDonald, Roger R Perry, Marvin Nice, Charles E. Hudson, E. Tom Thorne, A. Dermitzakis, Laura Viñuela, H. Cabrelli, Alison Loftus, L. Dawed, Iona Donnelly, E.R. Forgie, C.N. Pearson, A.A. Palmer, R. W. Brown, Anu Koivula, M. Wesolowska-Andersen, Nabil Abdalla, J. McRobert, J. Fernandez, Michael Kaye, A. Mourby, Mridul Mahajan, Nina S. McCarthy, Hetal Shah, Y. Teare, Ning Jiao, S. Robertson, Rachel Gough, A.D. Holl, Frieda A. Koopman, J.W. Rutters, L. Beulens, A.D. Groeneveld, J.D. Koopman, Eric L. Bell, Thomas, Brandon Whitcher,
Gastrointestinal adverse effects occur in 20-30% of patients with metformin-treated type 2 diabetes, leading to premature discontinuation in 5-10% of the cases. Gastrointestinal intolerance may reflect localized high concentrations of metformin in the gut. We hypothesized that reduced transport of metformin via the plasma membrane monoamine transporter (PMAT) and organic cation transporter 1 (OCT1) could increase the risk of severe gastrointestinal adverse effects.The study included 286 severe metformin- ...
Tópico(s): Pancreatic function and diabetes
2019 - American Diabetes Association | Diabetes Care
... Care, Lund University, Helsingborg Hospital, Lund, Sweden. Dr. Nielsen consulted for Bard Medical (Speaker fee). His institution received grant support from the Swedish heart-lung foundation, Swedish Research Council, Swedish Health Care system (ALF-grant), Regional grants, Skane County Council, Arbetsmarknadens försäkringsaktiebolag foundation, Stig and Ragna Gorthon foundation, and the Thelma Zoega foundation. For ...
Tópico(s): Respiratory Support and Mechanisms
2016 - Lippincott Williams & Wilkins | Critical Care Medicine
Alexandre Coimbra, Jordi Rimola, Míriam Cuatrecasas, Gert De Hertogh, Gert A. Van Assche, Ragna Vanslembrouck, Henning Glerup, Agnete Nielsen, Rikke Hagemann‐Madsen, Yoram Bouhnik, Magaly Zappa, Dominique Cazals–Hatem, Geert R. D’Haens, Jaap Stoker, Sybren L. Meijer, Gerhard Rogler, Andreas Boss, Achim Weber, Rui Zhao, Mary E. Keir, Alexis Scherl, Alex de Crespigny, Timothy T. Lu, Julián Panés,
Tópico(s): Diagnosis and treatment of tuberculosis
2017 - Elsevier BV | Gastroenterology
Ana M. Coimbra, Jordi Rimola, Míriam Cuatrecasas, Gert De Hertogh, Gert Van Assche, Ragna Vanslembrouck, Henning Glerup, Aage Nielsen, Rikke Hagemann‐Madsen, Yoram Bouhnik, Magaly Zappa, Dominique Cazals–Hatem, Geert R. D’Haens, Jaap Stoker, S. Meijer, Gerhard Rogler, Andreas Boss, Achim Weber, Ran Zhao, Mary E. Keir, Alexis Scherl, Alexander deCrespigny, Tao Lu, Julián Panés,
Background: Assessment of stenosis is important in the management of Crohn's Disease (CD). Magnetic Resonance Enterography (MRE) is a useful diagnostic tool for detecting bowel strictures, and parameters such as gadolinium contrast “delayed gain of enhancement” (DGE) and “magnetization transfer ratio” (MTR) have been associated with fibrosis in resected specimens. [1] [2] In an attempt to develop a CD MRE imaging protocol for clinical trial use, the purpose of this study was to identify MRE techniques that ...
Tópico(s): Radiomics and Machine Learning in Medical Imaging
2017 - Oxford University Press | Journal of Crohn s and Colitis
Andrea Tura, Eleonora Grespan, Christian Göbl, Robert W. Koivula, Paul W. Franks, Ewan R. Pearson, Mark Walker, Ian Forgie, Giuseppe N. Giordano, Imre Pávó, Hartmut Ruetten, Emmanouil T. Dermitzakis, Mark I. McCarthy, Oluf Pedersen, Jochen M. Schwenk, Jerzy Adamski, Federico De Masi, Konstantinos D. Tsirigos, Søren Brunak, Ana Viñuela, Anubha Mahajan, Timothy J. McDonald, Tarja Kokkola, Jagadish Vangipurapu, Henna Cederberg, Markku Laakso, Femke Rutters, Petra J. M. Elders, Anitra D.M. Koopman, Joline W. J. Beulens, Martin Ridderstråle, Tue H. Hansen, Kristine H. Allin, Torben Hansen, Henrik Vestergaard, Andrea Mari, Leen M. ‘t Hart, Moustafa Abdalla, Jonathan Adam, Jerzy Adamski, Kofi P. Adragni, Rosa Lundbye Allesøe, Kristine H. Allin, Manimozhiyan Arumugam, Naeimeh Atabaki Pasdar, Tania Baltauss, Karina Banasik, Patrick Baum, Jimmy D. Bell, Margit Bergstrom, Joline W. J. Beulens, Susaana Bianzano, Roberto Bizzotto, Amelie Bonneford, Caroline Brorsson, Andrew Brown, Søren Brunak, Louise Cabrelli, Robert Caïazzo, Mickaël Canouil, Henna Cederberg, Matilda Dale, David Davtian, Adem Y. Dawed, Federico De Masi, Nathalie de Préville, Koen F. Dekkers, Emmanouil T. Dermitzakis, Harshal Deshmukh, Christiane Dings, Louise A. Donnelly, Avirup Dutta, Beate Ehrhardt, Petra J. M. Elders, Line Engelbrechtsen, Rebeca Eriksen, Yong Fan, Juan Fernandez, Jorge Ferrer, Hugo Fitipaldi, Ian M. Forgie, Annemette Forman, Paul W. Franks, Francesca Frau, Andreas Fritsche, Philippe Froguel, Gary Frost, Johann Gassenhuber, Giuseppe N. Giordano, Toni Giorgino, Stephen Gough, Ulrike Graefe‐Mody, Harald Grallert, Rolf Grempler, Lenka Groeneveld, Leif Groop, Valborg Guðmundsdóttir, Ramneek Gupta, Mark Haid, Torben Hansen, Tue H. Hansen, Andrew T. Hattersley, Ragna S. Häussler, Alison Heggie, Anita M. Hennige, Anita Hill, Reinhard W. Holl, Mun‐Gwan Hong, Michelle Hudson, Bernd Jablonka, Christopher Jennison, Yunlong Jiao, Joachim Johansen, Angus G. Jones, Anna Jonsson, Tugce Karaderi, Jane Kaye, Maria Klintenberg, Robert W. Koivula, Tarja Kokkola, Anitra D.M. Koopman, Azra Kurbasic, Teemu Kuulasmaa, Markku Laakso, Thorsten Lehr, Heather Loftus, Agnete Troen Lundgaard, Anubha Mahajan, Andrea Mari, Gianluca Mazzoni, Mark I. McCarthy, Timothy J. McDonald, Donna McEvoy, Nicky McRobert, Ian McVittie, Miranda Mourby, Petra Musholt, Pascal M. Mutie, Rachel Nice, Claudia Nicolay, Agnes Martine Nielsen, Birgitte Nilsson, Giel Nijpels, Nicholette D. Palmer, François Pattou, Imre Pávó, Ewan R. Pearson, Oluf Pedersen, Helle K. Pedersen, Mandy H. Perry, Hugo Pomares‐Millan, Anna Ramisch, Simon Rasmussen, Violeta Raverdi, Martin Ridderstråle, Neil Robertson, Slieker Roderick, Marianne Rodriquez, Hartmut Ruetten, Femke Rutters, Peter Wad Sackett, Nina Scherer, Jochen M. Schwenk, Nisha Shah, Sapna Sharma, Iryna Sihinevich, Nadja B. Søndertoft, Hans‐Henrik Stærfeldt, Birgit Steckel-Hamann, Harriet Teare, Cecilia Engel Thomas, Melissa K. Thomas, E. Louise Thomas, Henrik S. Thomsen, Barbara Thorand, Claire E. Thorne, J. Tillner, Martina Troll, Konstantinos D. Tsirigos, Andrea Tura, Mathias Uhlén, Jagadish Vangipurapu, Nienke van Leeuwen, Sabine van Oort, Hélène Verkindt, Henrik Vestergaard, Ana Viñuela, Josef Korbinian Vogt, Peter Wad Sackett, Dianne Wake, Mark Walker, Agata Wesolowska‐Andersen, Brandon Whitcher, Margaret W. White, Han Wu,
Differences in glucose metabolism among categories of prediabetes have not been systematically investigated. In this longitudinal study, participants (N = 2,111) underwent a 2-h 75-g oral glucose tolerance test (OGTT) at baseline and 48 months. HbA1c was also measured. We classified participants as having isolated prediabetes defect (impaired fasting glucose [IFG], impaired glucose tolerance [IGT], or HbA1c indicative of prediabetes [IA1c]), two defects (IFG+IGT, IFG+IA1c, or IGT+IA1c), or all defects (IFG+ ...
Tópico(s): Diabetes, Cardiovascular Risks, and Lipoproteins
2021 - American Diabetes Association | Diabetes
Roberto Bizzotto, Christopher Jennison, Angus G. Jones, Azra Kurbasic, Andrea Tura, Gwen Kennedy, Jimmy D. Bell, E. Louise Thomas, Gary Frost, Rebeca Eriksen, Robert W. Koivula, Søren Brage, Jane Kaye, Andrew T. Hattersley, Alison Heggie, Donna McEvoy, Leen M. ‘t Hart, Joline W. J. Beulens, Petra Elders, Petra Musholt, Martin Ridderstråle, Tue H. Hansen, Kristine H. Allin, Torben Hansen, Henrik Vestergaard, Agnete Troen Lundgaard, Henrik S. Thomsen, Federico De Masi, Konstantinos D. Tsirigos, Søren Brunak, Ana Viñuela, Anubha Mahajan, Timothy J. McDonald, Tarja Kokkola, Ian M. Forgie, Giuseppe N. Giordano, Imre Pavo, Hartmut Ruetten, Emmanouil T. Dermitzakis, Mark I. McCarthy, Oluf Pedersen, Jochen M. Schwenk, Jerzy Adamski, Paul W. Franks, Mark Walker, Ewan R. Pearson, Andrea Mari, Moustafa Abdalla, Jonathan Adam, Jerzy Adamski, Kofi Adragni, Rosa Lundbye Allesøe, Kristine H. Allin, Manimozhiyan Arumugam, Naeimeh Atabaki Pasdar, Tania Baltauss, Karina Banasik, Patrick Baum, Jimmy D. Bell, Margit Bergstrom, Joline W. J. Beulens, Susanna Bianzano, Roberto Bizzotto, Amelie Bonneford, Caroline Brorsson, Andrew Brown, Søren Brunak, Louise Cabrelli, Robert Caïazzo, Mickaël Canouil, Matilda Dale, David Davtian, Adem Y. Dawed, Federico De Masi, Nathalie de Préville, Koen F. Dekkers, Emmanouil T. Dermitzakis, Harshal Deshmukh, Christiane Dings, Louise A. Donnelly, Avirup Dutta, Beate Ehrhardt, Petra Elders, Line Engelbrechtsen, Rebeca Eriksen, Juan Fernandez, Jorge Ferrer, Hugo Fitipaldi, Ian M. Forgie, Annemette Forman, Paul W. Franks, Francesca Frau, Andreas Fritsche, Philippe Froguel, Gary Frost, Johann Gassenhuber, Nick N. Giordano, Toni Giorgino, Stephen Gough, Ulrike Graefe‐Mody, Harald Grallert, Rolf Grempler, Lenka Groeneveld, Leif Groop, Valborg Guðmundsdóttir, Mark Haid, Torben Hansen, Tue H. Hansen, Andrew T. Hattersley, Ragna S. Häussler, Alison Heggie, Anita M. Hennige, Anita Hill, Reinhard W. Holl, Mun‐Gwan Hong, Michelle Hudson, Bernd Jablonka, Christopher Jennison, Yunlong Jiao, Joachim Johansen, Angus G. Jones, Anna Jonsson, Tugce Karaderi, Jane Kaye, Maria Klintenberg, Robert W. Koivula, Tarja Kokkola, Anitra D.M. Koopman, Azra Kurbasic, Teemu Kuulasmaa, Markku Laakso, Thorsten Lehr, Heather Loftus, Agnete Troen Lundgaard, Anubha Mahajan, Andrea Mari, Gianluca Mazzoni, Mark I. McCarthy, Timothy J. McDonald, Donna McEvoy, Nicky McRobert, Ian McVittie, Miranda Mourby, Petra Musholt, Pascal M. Mutie, Rachel Nice, Claudia Nicolay, Agnes Martine Nielsen, Birgitte Nilsson, Nicholette D. Palmer, François Pattou, Imre Pavo, Ewan R. Pearson, Helle K. Pedersen, Oluf Pedersen, Mandy H. Perry, Hugo Pomares‐Millan, Simon Rasmussen, Violeta Raverdy, Martin Ridderstråle, Neil Robertson, Slieker Roderick, Marianne Rodriquez, Hartmut Ruetten, Femke Rutters, Peter Wad Sackett, Nina Scherer, Jochen M. Schwenk, Nisha Shah, Sapna Sharma, Iryna Sihinevich, Nadja B. Søndertoft, Hans-Henrik Staerfeldt, Birgit Steckel-Hamann, Leen M. t Hart, Harriet Teare, Cecilia Engel Thomas, Melissa K. Thomas, E. Louise Thomas, Henrik S. Thomsen, Barbara Thorand, Claire E. Thorne, J. Tillner, Martina Troll, Konstantinos D. Tsirigos, Andrea Tura, Mathias Uhlén, Nienke van Leeuwen, Hélène Verkindt, Henrik Vestergaard, Ana Viñuela, Josef Korbinian Vogt, Dianne Wake, Mark Walker, Agata Wesolowska‐Andersen, Brandon Whitcher, Han Wu,
OBJECTIVE We investigated the processes underlying glycemic deterioration in type 2 diabetes (T2D). RESEARCH DESIGN AND METHODS A total of 732 recently diagnosed patients with T2D from the Innovative Medicines Initiative Diabetes Research on Patient Stratification (IMI DIRECT) study were extensively phenotyped over 3 years, including measures of insulin sensitivity (OGIS), β-cell glucose sensitivity (GS), and insulin clearance (CLIm) from mixed meal tests, liver enzymes, lipid profiles, and baseline ...
Tópico(s): Diabetes, Cardiovascular Risks, and Lipoproteins
2020 - American Diabetes Association | Diabetes Care
Noam Bar, Tal Korem, Omer Weissbrod, David Zeevi, Daphna Rothschild, Sigal Leviatan, Noa Kosower, Maya Lotan‐Pompan, Adina Weinberger, Caroline Le Roy, Cristina Menni, Alessia Visconti, Mario Falchi, Tim D. Spector, Henrik Vestergaard, Manimozhiyan Arumugam, Torben Hansen, Kristine H. Allin, Tue H. Hansen, Mun‐Gwan Hong, Jochen M. Schwenk, Ragna S. Häussler, Matilda Dale, Toni Giorgino, Marianne Rodriquez, Mandy H. Perry, Rachel Nice, Timothy J. McDonald, Andrew T. Hattersley, Angus G. Jones, Ulrike Graefe‐Mody, Patrick Baum, Rolf Grempler, Cecilia Engel Thomas, Federico De Masi, Caroline Brorsson, Gianluca Mazzoni, Rosa Lundbye Allesøe, Simon Rasmussen, Valborg Guðmundsdóttir, Agnes Martine Nielsen, Karina Banasik, Konstantinos D. Tsirigos, Birgitte Nilsson, Helle K. Pedersen, Søren Brunak, Tugce Karaderi, Agnete Troen Lundgaard, Joachim Johansen, Ramneek Gupta, Peter Wad Sackett, J. Tillner, Thorsten Lehr, Nina Scherer, Christiane Dings, Iryna Sihinevich, Heather Loftus, Louise Cabrelli, Donna McEvoy, Andrea Mari, Roberto Bizzotto, Andrea Tura, Leen M. ‘t Hart, Koen F. Dekkers, Nienke van Leeuwen, Roderick C. Slieker, Femke Rutters, Joline W. J. Beulens, Giel Nijpels, Anitra D.M. Koopman, Sabine van Oort, Lenka Groeneveld, Leif Groop, Petra J. M. Elders, Ana Viñuela, Anna Ramisch, Emmanouil Dermitzakis, Beate Ehrhardt, Christopher Jennison, Philippe Froguel, Mickaël Canouil, Amélie Boneford, Ian McVittie, Dianne Wake, Francesca Frau, Hans‐Henrik Stærfeldt, Kofi P. Adragni, Melissa K. Thomas, Han Wu, Imre Pavo, Birgit Steckel-Hamann, Henrik S. Thomsen, Giuseppe N. Giordano, Hugo Fitipaldi, Martin Ridderstråle, Azra Kurbasic, Naeimeh Atabaki Pasdar, Hugo Pomares‐Millan, Pascal M. Mutie, Robert W. Koivula, Nicky McRobert, Mark I. McCarthy, Agata Wesolowska‐Andersen, Anubha Mahajan, Moustafa Abdalla, Juan Fernandez, Reinhard W. Holl, Alison Heggie, Harshal Deshmukh, Anita M. Hennige, Susanna Bianzano, Barbara Thorand, Sapna Sharma, Harald Grallert, Jonathan Adam, Martina Troll, Andreas Fritsche, Anita Hill, Claire E. Thorne, Michelle Hudson, Teemu Kuulasmaa, Jagadish Vangipurapu, Markku Laakso, Henna Cederberg, Tarja Kokkola, Yunlong Jiao, Stephen Gough, Neil Robertson, Hélène Verkindt, Violeta Raverdi, Robert Caïazzo, François Pattou, Margaret H. White, Louise A. Donnelly, Andrew Brown, Nicholette D. Palmer, David Davtian, Adem Y. Dawed, Ian Forgie, Ewan R. Pearson, Hartmut Ruetten, Petra Musholt, Jimmy D. Bell, E. Louise Thomas, Brandon Whitcher, Mark Haid, Claudia Nicolay, Miranda Mourby, Jane Kaye, Nisha Shah, Harriet Teare, Gary Frost, Bernd Jablonka, Mathias Uhlén, Rebeca Eriksen, Josef Korbinian Vogt, Avirup Dutta, Anna Jönsson, Line Engelbrechtsen, Annemette Forman, Nadja B. Søndertoft, Nathalie de Préville, Tania Baltauss, Mark Walker, Johann Gassenhuber, Maria Klintenberg, Margit Bergstrom, Jorge Ferrer, Jerzy Adamski, Paul W. Franks, Oluf Pedersen, Eran Segal,
The serum metabolome contains a plethora of biomarkers and causative agents of various diseases, some of which are endogenously produced and some that have been taken up from the environment1. The origins of specific compounds are known, including metabolites that are highly heritable2,3, or those that are influenced by the gut microbiome4, by lifestyle choices such as smoking5, or by diet6. However, the key determinants of most metabolites are still poorly understood. Here we measured the levels ...
Tópico(s): Bioinformatics and Genomic Networks
2020 - Nature Portfolio | Nature
Adem Y. Dawed, Andrea Mari, Andrew Brown, Timothy J. McDonald, Lin Li, Shuaicheng Wang, Mun‐Gwan Hong, Sapna Sharma, Neil R. Robertson, Anubha Mahajan, Xuan Wang, Mark Walker, Stephen Gough, Leen M. ‘t Hart, Kaixin Zhou, Ian Forgie, Hartmut Ruetten, Imre Pávó, Pallav Bhatnagar, Angus G. Jones, Ewan R. Pearson, Leen M. ‘t Hart, Mohamed Elhassan Abdalla, Jean‐Michel Adam, J. Adamski, Kofi P. Adragni, Kristine H. Allin, Manimozhiyan Arumugam, Naeimeh Atabaki Pasdar, Tania Baltauss, Kamil Banasik, Patrick Baum, Jimmy D. Bell, Mats Bergström, Joline W. J. Beulens, Susaana Bianzano, Roberto Bizzotto, Amelie Bonneford, Caroline Brorsson, A.A. Brown, S.B. Brunak, Louise Cabrelli, Robert Caïazzo, Mickaël Canouil, M.M. Dale, David Davtian, Adem Y. Dawed, F.M. De Masi, Nathalie de Préville, Koen F. Dekkers, E. T. Dermitzakis, Harshal Deshmukh, Christiane Dings, Louise Donnelly, Avirup Dutta, Beate Ehrhardt, Petra J. M. Elders, Cecilia Engel Thomas, Line Engelbrechtsen, R.G. Eriksen, R.E. Eriksen, Yong Fan, J. Fernandez, José Illnait Ferrer, Hugo Fitipaldi, Ian Forgie, Axel Forman, Paul W. Franks, Franco Frau, A. Fritsche, P. Froguel, Gary Frost, Johann Gassenhuber, Guillermo Giordano, Toni Giorgino, Stephen Gough, Ulrike Graefe‐Mody, H. Grallert, Rolf Grempler, Lenka Groeneveld, Leif Groop, V Gudmundsdottir, R.G. Gupta, Mark Haid, T. Hansen, Tue H. Hansen, Andrew T. Hattersley, Ragna S. Häussler, A.J. Heggie, Anita M. Hennige, Adrian V. S. Hill, Reinhard W. Holl, Mun‐Gwan Hong, Michelle Hudson, Bernd Jablonka, Christopher Jennison, Jian Jiao, Jon Johansen, Adam G. Jones, A. Jonsson, Tugce Karaderi, Jane Kaye, Maria Klintenberg, Robert W. Koivula, Tarja Kokkola, Anitra D.M. Koopman, A Kurbasic, T. Kuulasmaa, M. Laakso, Thorsten Lehr, Hannah Loftus, R.L.A Lundbye Allesøe, Anubha Mahajan, Andrea Mari, Gianluca Mazzoni, Mark I. McCarthy, Timothy J. McDonald, Donald McEvoy, Nicky McRobert, Ian McVittie, Miranda Mourby, PB Musholt, Pascal M. Mutie, Rachel Nice, Claudia Nicolay, Agnes Martine Nielsen, Birgitte Nilsson, Nicholette D. Palmer, François Pattou, Imre Pávó, Ewan R. Pearson, Oluf Pedersen, Helle K. Pedersen, Mandy H. Perry, Hugo Pomares‐Millan, Anna Ramisch, Sebastian Buhl Rasmussen, V. Raverdi, Martin Ridderstråle, N. Robertson, Ryland Roderick, M. Rodriquez, Hartmut Ruetten, Femke Rutters, Walter G. Sackett, N. Scherer, Jochen M. Schwenk, N. Jon Shah, Sapna Sharma, Iryna Sihinevich, Nadja B. Søndertoft, Hans‐Henrik Stærfeldt, Birgit Steckel-Hamann, Harriet Teare, Melissa K. Thomas, E. Louise Thomas, Henrik S. Thomsen, Barbara Thorand, Claire E. Thorne, J. Tillner, A.T.L. Troen Lundgaard, Mark Troll, Kostas Tsirigos, Andrea Tura, Mathias Uhlén, Nienke van Leeuwen, Sabine van Oort, Hélène Verkindt, Henrik Vestergaard, A. Viñuela, Josef Korbinian Vogt, P.W.S Wad Sackett, Deborah J. Wake, Mark Walker, Agata Wesolowska‐Andersen, Brandon Whitcher, Matthew White, Han Wu,
In the treatment of type 2 diabetes, GLP-1 receptor agonists lower blood glucose concentrations, body weight, and have cardiovascular benefits. The efficacy and side effects of GLP-1 receptor agonists vary between people. Human pharmacogenomic studies of this inter-individual variation can provide both biological insight into drug action and provide biomarkers to inform clinical decision making. We therefore aimed to identify genetic variants associated with glycaemic response to GLP-1 receptor ...
Tópico(s): Genetic Associations and Epidemiology
2022 - Elsevier BV | The Lancet Diabetes & Endocrinology
Ragna Guldsmed Diedrichsen, Narendra Kumar Mishra, Freja Fredholt, Joanne Heade, Kasper K. Sørensen, Knud J. Jensen, Hanne Mørck Nielsen,
Tópico(s): Lipid Membrane Structure and Behavior
2025 - Elsevier BV | Journal of Controlled Release