Theresia Sarabhai, Lucia Mastrototaro, S. Kahl, Gidon J. Bönhof, Marc Jonuscheit, Pavel Bobrov, Hisayuki Katsuyama, Rainer Guthoff, Martin Wolkersdorfer, Christian Herder, Sven G. Meuth, Sven Dreyer, Michael Roden,
Hyperbaric oxygen (HBO) therapy may improve hyperglycaemia in humans with type 2 diabetes, but underlying mechanisms are unclear. Our objective was to examine the glucometabolic effects of HBO on whole-body glucose disposal in humans with type 2 diabetes.In a randomised placebo-controlled crossover trial located at the German Diabetes Center, 12 male individuals with type 2 diabetes (age 18-75 years, BMI <35 kg/m2, HbA1c 42-75 mmol/mol [6-9%]), randomly allocated by one person, underwent 2-h HBO, once ...
Tópico(s): Metabolism, Diabetes, and Cancer
2022 - Springer Science+Business Media | Diabetologia
Martin Schön, Katsiaryna Prystupa, Tim Mori, Oana‐Patricia Zaharia, Kálmán Bódis, Maria Bombrich, Clara Möser, Iryna Yurchenko, Yuliya Kupriyanova, Klaus Straßburger, Pavel Bobrov, Anand Thakarakkattil Narayanan Nair, Gidon J. Bönhof, Alexander Strom, Graciela E. Delgado, Sema Kaya, Rainer Guthoff, Norbert Stefan, Andreas L. Birkenfeld, Hans Hauner, Jochen Seißler, A. Pfeiffer, Matthias Blüher, Stefan R. Bornstein, Julia Szendroedi, Svenja Meyhöfer, Sandra Trenkamp, Volker Burkart, Vera B. Schrauwen‐Hinderling, Marcus E. Kleber, Alexander Niessner, Christian Herder, Oliver Kuß, Winfried März, Ewan R. Pearson, Michael Roden, Róbert Wágner, Hadi Al‐Hasani, Bengt‐Frederik Belgardt, Gidon J. Bönhof, Gerd Geerling, Christian Herder, Andrea Icks, Karin Jandeleit‐Dahm, Jörg Kotzka, Oliver Kuß, Eckhard Lammert, Wolfgang Rathmann, Michael Roden, Sabrina Schlesinger, Vera B. Schrauwen‐Hinderling, Julia Szendroedi, Sandra Trenkamp, Róbert Wágner,
Background Heterogeneity in type 2 diabetes can be represented by a tree-like graph structure by use of reversed graph-embedded dimensionality reduction. We aimed to examine whether this approach can be used to stratify key pathophysiological components and diabetes-related complications during longitudinal follow-up of individuals with recent-onset type 2 diabetes. Methods For this cohort analysis, 927 participants aged 18–69 years from the German Diabetes Study (GDS) with recent-onset type 2 diabetes ...
Tópico(s): Cardiovascular Function and Risk Factors
2023 - Elsevier BV | The Lancet Diabetes & Endocrinology
Kálmán Bódis, Maria Bombrich, Martin Schön, Birgit Knebel, Oana‐Patricia Zaharia, Gidon J. Bönhof, Yanislava Karusheva, Klaus Straßburger, Yuliya Kupriyanova, Jörg Kotzka, Rainer Guthoff, Vera B. Schrauwen‐Hinderling, Hadi Al‐Hasani, Volker Burkart, Julia Szendroedi, Róbert Wágner, Daniel F. Markgraf, Michael Roden,
Background and aims: Increased hepatocellular lipid content (HCL) is linked to insulin resistance, risk of type 2 diabetes and related complications.Conversely, a single-nucleotide polymorphism (TM6SF2 EK ; rs58542926) in the transmembrane 6 superfamily member 2-gene has been associated with nonalcoholic fatty liver disease (NAFLD), but lower cardiovascular risk.This case-control study tested the role of this polymorphism for tissue-specific insulin sensitivity during early course of diabetes.Methods ...
Tópico(s): Metabolism, Diabetes, and Cancer
2023 - Elsevier BV | Nutrition Metabolism and Cardiovascular Diseases
Martin Schön, KATSIARYNA PRYSTUPA, TIM MORI, Oana‐Patricia Zaharia, Kálmán Bódis, Yuliya Kupriyanova, Anand Thakarakkattil Narayanan Nair, ALEXANDER STROM, Rainer Guthoff, GIDON J. BÖNHOF, Andreas L. Birkenfeld, Jochen Seißler, ANDREAS F. PFEIFFER, MATTHIAS BLÜHER, Stefan R. Bornstein, Julia Szendroedi, SVENJA MEYHOEFER, Volker Burkart, VERA SCHRAUWEN-HINDERLING, Oliver Kuß, Ewan R. Pearson, Michael Roden, Róbert Wágner,
Heterogeneity in type 2 diabetes (T2D) can be represented by a tree-like structure using reverse graph-embedded dimensionality reduction. We aimed to validate this approach and study if intensified phenotyping stratifies complications. Participants (n=927) of the German Diabetes Study (GDS) with recent-onset T2D were mapped onto a two-dimensional tree based on HbA1c, BMI, total and HDL cholesterol, triglycerides, alanine aminotransferase, creatinine, systolic and diastolic blood pressure, residualized ...
Tópico(s): Diet and metabolism studies
2023 - American Diabetes Association | Diabetes
Kálmán Bódis, Maria Bombrich, Martin Schön, Birgit Knebel, Oana‐Patricia Zaharia, GIDON J. BÖNHOF, Yanislava Karusheva, Yuliya Kupriyanova, Jörg Kotzka, Rainer Guthoff, VERA SCHRAUWEN-HINDERLING, Hadi Al‐Hasani, Volker Burkart, Julia Szendroedi, Róbert Wágner, Daniel F. Markgraf, Michael Roden,
Increased hepatocellular lipid content (HCL) is generally linked to insulin resistance, which contributes to greater risk of type 2 diabetes and cardiovascular complications. Conversely, a single-nucleotide polymorphism (TM6SF2EK; rs58542926) in the transmembrane 6 superfamily member 2 gene has been associated with nonalcoholic fatty liver disease (NAFLD), but lower cardiovascular risk. Thus, this case-control study tested the role of this polymorphism for tissue-specific insulin sensitivity during ...
Tópico(s): Cancer, Lipids, and Metabolism
2023 - American Diabetes Association | Diabetes
Katharina S. Weber, Sabrina Schlesinger, Janina Goletzke, Klaus Straßburger, Oana‐Patricia Zaharia, Sandra Trenkamp, Róbert Wágner, Wolfgang Lieb, Anette E. Buyken, Michael Roden, Christian Herder, Michael Roden, Hadi Al‐Hasani, B. Belgardt, Gidon J. Bönhof, Gerd Geerling, Rainer Guthoff, C. Herder, Andrea Icks, K. Jandeleit-Dahm, Jörg Kotzka, Oliver Kuß, E. Lammert, Wolfgang Rathmann, Sabrina Schlesinger, Vera B. Schrauwen‐Hinderling, Julia Szendroedi, Sandra Trenkamp, Robin S. Wagner,
Tópico(s): Diet and metabolism studies
2025 - BioMed Central | Cardiovascular Diabetology
Kálmán Bódis, Katsiaryna Prystupa, Oana‐Patricia Zaharia, Martin Schön, Clara Möser, Iryna Yurchenko, Dania Mendez, Pavel Bobrov, Geronimo Heilmann, Yuliya Kupriyanova, Vera B. Schrauwen‐Hinderling, Klaus Straßburger, Gidon J. Bönhof, Volker Burkart, Rainer Guthoff, Svenja Meyhöfer, Andreas L. Birkenfeld, Reiner Jumpertz von Schwartzenberg, Hans Hauner, Jochen Seißler, A. Pfeiffer, Matthias Blüher, Stefan R. Bornstein, Ζoltan Κender, Alba Sulaj, Julia Szendrödi, Michael Roden, Róbert Wágner,
Fragestellung: Insulinresistenz ist ein zentrales pathophysiologisches Merkmal des Typ-2-Diabetes (T2D) und zeigt sich in unterschiedlichem Ausmaß auch bei Typ-1-Diabetes (T1D) und Prädiabetes. Ziel dieser Studie war es, Muster der gewebespezifischen Insulinresistenz zu erkennen, um ihren Beitrag zur metabolischen Heterogenität zu verstehen.
Tópico(s): Diabetes Management and Research
2024 - Georg Thieme Verlag | Diabetologie und Stoffwechsel
Kálmán Bódis, KATSIARYNA PRYSTUPA, Oana‐Patricia Zaharia, Martin Schön, CLARA MÖSER, Iryna Yurchenko, DANIA M. MENDEZ CARDENAS, PAVEL BOBROV, GERONIMO HEILMANN, VERA SCHRAUWEN-HINDERLING, Klaus Straßburger, GIDON J. BÖNHOF, Volker Burkart, Rainer Guthoff, SVENJA MEYHOEFER, Andreas L. Birkenfeld, REINER JUMPERTZ VON SCHWARTZENBERG, Jochen Seißler, ANDREAS F. PFEIFFER, MATTHIAS BLÜHER, Stefan R. Bornstein, ZOLTAN KENDER, ALBA SULAJ, Martin Heni, Julia Szendroedi, Michael Roden, Róbert Wágner,
Introduction & Objective: Insulin resistance is a central pathophysiologic feature of type 2 diabetes (T2D), and to varying degrees also present in type 1 diabetes (T1D) and prediabetes. This study aims to discern patterns of tissue-specific insulin resistance to understand its contribution to metabolic heterogeneity. Methods: This study used k-means clustering in 759 participants (223 T1D, 346 T2D, 190 glucose-tolerant individuals as control, CON) of the German Diabetes Study (GDS). The clusters were ...
Tópico(s): Nutrition, Genetics, and Disease
2024 - American Diabetes Association | Diabetes
Kálmán Bódis, Maria Bombrich, Martin Schön, Birgit Knebel, Oana‐Patricia Zaharia, Gidon J. Bönhof, Yanislava Karusheva, Jörg Kotzka, Rainer Guthoff, Vera B. Schrauwen‐Hinderling, Hadi Al‐Hasani, Volker Burkart, Julia Szendrödi, Róbert Wágner, Daniel F. Markgraf, Michael Roden,
Fragestellung Ein erhöhter hepatozellulärer Lipidgehalt (HCL) steht in engem Zusammenhang mit Insulinresistenz, was zu einem höheren Risiko für Typ-2-Diabetes und damit verbundenen Komplikationen beitragen kann. Umgekehrt wurde der Einzelnukleotid-Polymorphismus (TM6SF2EK; rs58542926) im Transmembran 6-Superfamilienmitglied 2 Gen mit nichtalkoholischer Fettlebererkrankung (NAFLD) und einem geringeren kardiovaskulären Risiko in Verbindung gebracht. In der aktuellen Fall-Kontroll-Studie wurde untersucht, ...
Tópico(s): Diabetes, Cardiovascular Risks, and Lipoproteins
2023 - Georg Thieme Verlag | Diabetologie und Stoffwechsel
Martin Schön, Katsiaryna Prystupa, Tim Mori, Oana‐Patricia Zaharia, Kálmán Bódis, Yuliya Kupriyanova, Anand Thakarakkattil Narayanan Nair, Alexander Strom, Rainer Guthoff, Sema Kaya, Gidon J. Bönhof, Andreas L. Birkenfeld, Hans Hauner, Jochen Seißler, A. Pfeiffer, Matthias Blüher, Stefan R. Bornstein, Julia Szendrödi, Svenja Meyhöfer, Volker Burkart, Vera B. Schrauwen‐Hinderling, Oliver Kuß, Ewan R. Pearson, Michael Roden, Róbert Wágner,
Typ-2-Diabetes (T2D) ist eine heterogene Erkrankung mit variierendem Krankheitsverlauf und Risiko für Komplikationen. Die metabolische Heterogenität des T2D kann nach Anwendung eines neuartigen Dimensionalitätsreduktionsverfahrens auf einer zweidimensionalen Baumstruktur visualisiert werden, sodass jede Person basierend auf 9 allgemein-verfügbaren klinischen Variablen an einer spezifischen Position dieser Baumstruktur dargestellt wird. Ziel der Studie war, dieses Verfahren zu validieren und zu untersuchen, ...
Tópico(s): Clinical practice guidelines implementation
2023 - Georg Thieme Verlag | Diabetologie und Stoffwechsel