... cell (RGC) layer. Rodent anterior ischemic optic neuropathy (rAION) is an optic nerve infarct, which results in ... in mice. The goal was to determine whether rAION produces changes in amacrine cell neurons. Methods.: rAION was generated in transgenic mice carrying a cyan ... Thy-1 promoter, which expresses CFP in RGCs. rAION was induced with standard parameters. Retinas were examined pre-and post-induction by retinal fundus microscopy. rAION induction severity was scored by changes in retinal ... by confocal microscopy and western analysis. Results.: Moderate rAION induction levels (defined as early retention of retinal ...
Tópico(s): Intraoperative Neuromonitoring and Anesthetic Effects
2010 - Cadmus Press | Investigative Ophthalmology & Visual Science
Кимитака Мацузато, М. А. Ибрагимов,
... Makhachkala (23 February 2004) and Belidzhi town, Derbent raion (26 February 2004) respectively. Shamil' Shikhaliev, a former ... belongs to the Kumyk opposition) in Makhachkala. 'Tabasaran raion is one of the largest raiony in the ... R. Ibragimov, 6 April 2004). The only Kumyk raion which recognises the DUMD's leadership is Buinaksk ... by the authors in Gimry village, Untsukul'sk raion, 23 August 2003. Ramazan-khadzhi Gazimagomedov, chairman of the Untsukul'sk raion council of ulama and imams, interviewed by the ...
Tópico(s): Islamic Studies and History
2005 - Routledge | Europe Asia Studies
L. D. Romanchuk, L. Herasymchuk, S. Kovalyova, Yu. V. Kovalchuk, O. V. Lopatyuk,
... Yemilchyno, Malyn, Korosten, Narodychi, Olevsk, Luhyny and Ovruch raions of the Zhytomyr region. The basis for the ... life of the population of radioactively contaminated administrative raions of the Zhytomyr region were the statistical data ... maximum values are representative of Malyn and Korosten raions). Natural population decline rates in rural settlements exceeded ... values for urban settlements from 1.4 (Malyn raion) to 13 times (Olevsk raion). There is also the aging of the population, ... 8% are resident in the Korosten and Narodychi raions. The values of birth rates (7.5 (Ovruch ...
Tópico(s): Economic Issues in Ukraine
2019 - Alex Matsyura Publishing | Ukrainian Journal of Ecology
Tzu‐Lun Huang, Yao‐Tseng Wen, Yu-Chieh Ho, Jia-Kang Wang, Kuan‐Hung Lin, Rong‐Kung Tsai,
... a rat model of anterior ischemic optic neuropathy (rAION).Rats were daily gavaged with ALG after rAION induction for seven days. The therapeutic effects of ALG on rAION were evaluated using flash visual evoked potentials (FVEPs), ... treated group (p = 0.032) than in the rAION group. The density of RGCs was 2.4- ... ALG-treated group compared to that in the rAION group (p < 0.0001). The number of ED1- ... ALG-treated group compared to those in the rAION group (p = 0.029). The number of apoptotic ... group (p = 0.001) than that in the rAION group. The ALG treatment inhibited ERK activation to ...
Tópico(s): Glaucoma and retinal disorders
2020 - Multidisciplinary Digital Publishing Institute | Marine Drugs
Bernard J. Slater, Zara Mehrabian, Yan Guo, Allan A. Hunter, Steven L. Bernstein,
... An NAION model, rodent anterior ischemic optic neuropathy (rAION), was used to determine AION-associated mechanisms of RGC death and associated regional retinal changes.rAION was induced in male Wistar rats, and the ... an antibody that recognizes cleaved caspase-3.Post-rAION, RGCs die by apoptosis over a longer period ... immunoreactivity was greatest between 11 and 15 days. rAION-induced RGC death occurs regionally, with sparing of large contiguous regions of RGCs.rAION results in later RGC death than in traumatic ...
Tópico(s): Glaucoma and retinal disorders
2008 - Cadmus Press | Investigative Ophthalmology & Visual Science
Yao‐Tseng Wen, Tzu‐Lun Huang, Sung-Ping Huang, Chung‐Hsing Chang, Rong‐Kung Tsai,
... a rat model of anterior ischemic optic neuropathy (rAION). However, the therapeutic window and anti-inflammatory effects of G-CSF in a rAION model have yet to be elucidated. Thus, this ... regulation of optic nerve (ON) inflammation in a rAION model. Rats were treated with G-CSF on day 0, 1, 2, and 7 post-rAION induction for 5 consecutive days, and a control ... flash visual evoked potentials at 4 weeks post-rAION induction. The survival rate and apoptosis of retinal ... treatment starting on day 0 and 1 post-rAION induction, respectively, compared with the PBS-treated group ( ...
Tópico(s): Glaucoma and retinal disorders
2016 - The Company of Biologists | Disease Models & Mechanisms
Nitza Goldenberg‐Cohen, Shimrit Dadon‐Bar‐El, Murat Hasanreisoğlu, Bat-Chen R. Avraham-Lubin, Olga Dratviman‐Storobinsky, Yoram Cohen, Dov Weinberger,
... following induction of ischaemic optic neuropathy in rodents (rAION). Methods: Mice were treated with an intraperitoneal injection of brimonidine 48, 24 or 0 h before rAION induction or eye drops for 5 days after rAION induction. Retinal ganglion cell (RGC) loss and expression ... to ischaemic damage were compared with sham or rAION‐untreated mice. Results: No RGC loss was detected in the brimonidine‐treated mice. Effect of post‐rAION eye drops: day 1 – no decrease in retinal ... change in angiogenesis‐related genes. Effect of pre‐rAION injection: baseline levels of angiogenesis‐related genes with ...
Tópico(s): Retinal Diseases and Treatments
2009 - Wiley | Clinical and Experimental Ophthalmology
Steven L. Bernstein, Yan Guo, Bernard J. Slater, Adam C. Puché, Michael J. Elman,
... ganglion cell (RGC) neurons. The rodent NAION model (rAION) can use transgenic mouse strains to reveal unique ... on RGCs and their axons. The impact of rAION on RGC stress patterns, RGC loss, and their ... analysis of CFP(+) RGC numbers and loss post-rAION-using confocal microscopy. RGC loss was correlated with ... was used to evaluate retinal cell stress after rAION.The 45,000 CFP(+) cells in the RGC ... control animals compared with previous RGC quantitative estimates. rAION produced RGC stress, defined as lacZ expression, in ...
Tópico(s): Glaucoma and retinal disorders
2007 - Cadmus Press | Investigative Ophthalmology & Visual Science
Robert G. Moser, Allison C. White,
... been driven, in part, by diffusion across neighboring raions through emulation, incentives, and networks. Presumably, in Putin' ... s party arguably increases considerably if one's raion is located in a region marked by extraordinarily ... may help explain the absence of fraud among raions located in regions marked by clean elections. Our ... that a "neighborhood effect" – the existence of manipulated raions within a region – strongly influences the likelihood that raions are manipulated. Moreover, although results are more mixed, ...
Tópico(s): Electoral Systems and Political Participation
2016 - Taylor & Francis | Post-Soviet Affairs
Steven L. Bernstein, Yan Guo, Michael J. Elman, Robert W. Flower, Mary A. Johnson,
... to design a novel model of rodent AION (rAION), to enable more detailed study of this disease. ... changes occurred in RGCs within 1 day after rAION, with a loss of visual evoked potential (VEP) ... The retinal gene expression pattern rapidly changed after rAION induction, with an early (<1 day) initial induction ... retinal layers react to isolated RGC axonal ischemia.rAION rapidly results in electrophysiological and histologic changes similar ... in primary and supporting neuronal cell layers. The rAION model can enable a detailed analysis of the ...
Tópico(s): Retinal Diseases and Treatments
2003 - Cadmus Press | Investigative Ophthalmology & Visual Science
Valérie Touitou, Mary A. Johnson, Yan Guo, Neil R. Miller, Steven L. Bernstein,
... is neuroprotective in our rodent model of AION (rAION). In this study, we determined if a single intravitreal (IVT) injection of PGJ2 is neuroprotective after rAION, and if this method of administration is toxic ... Long-Evans rats. Efficacy was assessed by inducing rAION in one eye and injecting either PGJ2 or ... preservation of RGCs and axons in eyes with rAION. Conclusions.: A single IVT injection of PGJ2 is ... optic nerve and neuroprotective when given immediately after rAION induction.
Tópico(s): Traumatic Brain Injury and Neurovascular Disturbances
2013 - Cadmus Press | Investigative Ophthalmology & Visual Science
Tzu‐Lun Huang, Yao‐Tseng Wen, Chung‐Hsing Chang, Shu‐Wen Chang, Kuan‐Hung Lin, Rong‐Kung Tsai,
... in a rat model of ischemic optic neuropathy (rAION). Methods: The optic nerve (ON) vascular permeability was ... PCR) from day 1 to day 5 post-rAION. Rats were treated with MP starting on days 0, 1, 2, and 7 post-rAION. The survival and apoptosis of the RGCs were ... with decreased expression of proinflammatory cytokines in acute rAION. The very narrow therapeutic window is related to ...
Tópico(s): Anesthesia and Pain Management
2017 - Cadmus Press | Investigative Ophthalmology & Visual Science
Kishan Kapupara, Tzu‐Lun Huang, Yao‐Tseng Wen, Shun‐Ping Huang, Rong‐Kung Tsai,
... a rat model of anterior ischemic optic neuropathy (rAION). We established an in vivo validation index by ... retinal nerve fiber layer (RNFL) thickness in the rAION model using optical coherence tomography (OCT). The rAION model was induced by photodynamic operations. We measured ... and P1-N2 amplitude were significantly reduced in rAION. Our data suggest that Swelling, reduction of swelling, ... essential events for confirming the successful induction of rAION.
Tópico(s): Intraocular Surgery and Lenses
2018 - Elsevier BV | Experimental Eye Research
Zara Mehrabian, Yan Guo, Neil R. Miller, Amanda D. Henderson, Steven Roth, Steven L. Bernstein,
... ON)-related vision loss. The rodent NAION model (rAION) closely resembles NAION in presentation and physiological responses. We identified early rAION-associated optic nerve head (ONH) inflammatory gene expression ... on vehicle- and PGJ2-treated ONHs 3d post-rAION induction. Results were compared against responses from a ... PGJ2 treatment nonselectively reduced inflammatory gene expression post-rAION. KML29 did not reduce PGE2 1d post-induction and KML29 alone increased RGC loss after rAION. Combined treatments did not improve ONH edema and ...
Tópico(s): Intraocular Surgery and Lenses
2021 - Multidisciplinary Digital Publishing Institute | Cells
Rong‐Kung Tsai, Shun‐Ping Huang,
... that the protective actions of G-CSF in rAION models may involve both anti-apoptotic and anti- ... involved in the administration of G-CSF in rAION models need further investigation. In addition, further studies ... at different time intervals after the induction of rAION may be able to illustrate whether treatment given ... will result in a synergistic effect in a rAION model. Inflammation induced by ischemia plays an essential ...
Tópico(s): Anesthesia and Pain Management
2014 - Medknow | Neural Regeneration Research
Michaela K. Mathews, Yan Guo, Patricia Langenberg, Steven L. Bernstein,
... ischaemic event using rodent anterior ischaemic optic neuropathy (rAION), a mouse model of non-arteritic anterior ischaemic optic neuropathy (NAION). Methods We induced rAION in Thy1- cyan fluorescent protein (CFP) transgenic mice ... following intravenous rose bengal injection. One day after rAION induction, an intravitreal injection of 0.75 μg ... between the different groups. Results Two weeks after rAION induction, significantly more (CFP+) cells were preserved in ...
Tópico(s): Optical Coherence Tomography Applications
2014 - BMJ | British Journal of Ophthalmology
Kishan Kapupara, Yao‐Tseng Wen, Rong‐Kung Tsai, Shun‐Ping Huang,
... protein in a rat anterior ischemic optic neuropathy (rAION) model. rAION was induced by photodynamic therapy. P-sel-IgG ... nerve barrier (BONB) in the acute phase of rAION. Further, P-sel-IgG increased the retinal ganglion ... and activating the Nrf2 signaling pathway in a rAION model.
Tópico(s): Neuroinflammation and Neurodegeneration Mechanisms
2017 - Springer Nature | Cell Death and Disease
Tassos Georgiou, Yao‐Tseng Wen, Chung‐Hsing Chang, Panagiotis Kolovos, Maria Kalogerou, Ekatherine Prokopiou, Anastasia Neokleous, Chin‐Te Huang, Rong‐Kung Tsai,
... a rat model of anterior ischemic optic neuropathy (rAION). Methods: The level of blood arachidonic acid/eicosapentaenoic ... was measured to determine the suggested dosage. The rAION-induced rats were administered fish oil (1 g/ ... nerve (ON) by 3.17-fold in the rAION model. The M2 macrophage markers, which decrease inflammation, ... of ω-3 PUFAs has neuroprotective effects in rAION, possibly through dual actions of the antiapoptosis of ...
Tópico(s): Neurological Complications and Syndromes
2017 - Cadmus Press | Investigative Ophthalmology & Visual Science
Luciano S. Pereira, Marcos Pereira de Ávila, Luciana Ximenes Salustiano, Álcio Coutinho de Paula, Emmanuel Arnhold, Timothy J. McCulley,
... a rodent model of anterior ischemic optic neuropathy (rAION).The rAION was induced in female Wistar rats. Animals were ... average number of RGC was significantly lower in rAION subgroups when compared with the control group (P < 0.001). No significant difference was seen between rAION eyes treated with IVTA, placebo, and untreated eyes ( ...
Tópico(s): Retinal and Optic Conditions
2018 - Lippincott Williams & Wilkins | Journal of Neuro-Ophthalmology
Minh-Anh Nguyen Ngo Le, Yao‐Tseng Wen, Yu-Chieh Ho, Kishan Kapupara, Rong‐Kung Tsai,
... a rat model of anterior ischemic optic neuropathy (rAION). Methods: The neuroprotective effects of PR on rAION were evaluated using flash visual-evoked potentials (FVEP), ... of IL-10, Arg1, and Fizz1 in the rAION model. The levels of p-Akt1 and C/ ... PR treatment provided the neuroprotective effects in the rAION model, which may lead to new clinical applications.
Tópico(s): Glaucoma and retinal disorders
2019 - Cadmus Press | Investigative Ophthalmology & Visual Science
Yu-Yau Chou, Jia-Ying Chien, Jhih-Wei Ciou, Shun‐Ping Huang,
... BP) treatment in an experimental NAION rodent model (rAION). BP (10 mg/kg) or PBS (control group) were administered on seven consecutive days in the rAION model. Rats were evaluated for visual function by ... The molecular machinery of BP treatment in the rAION model was analyzed using Western blotting. We discovered ... the integrity of the myelin sheath in the rAION model, demonstrating that BP can prevent the development ...
Tópico(s): Neuroinflammation and Neurodegeneration Mechanisms
2022 - Multidisciplinary Digital Publishing Institute | International Journal of Molecular Sciences
Zuohuizi Yi, Liao Chen, Xiaoling Wang, Changzheng Chen, Yiqiao Xing,
... rodent model of nonarteritic anterior ischemic optic neuropathy (rAION).The rAION model was established by using laser-induced photoactivation ... or PBS 1, 3, and 6 days after rAION induction. Optical coherence tomography (OCT) was performed at ... edema, RGC survival, and visual function preservation in rAION.
Tópico(s): Retinal Development and Disorders
2020 - Hindawi Publishing Corporation | Journal of Ophthalmology
Bat Chen R. Avraham, Gad Dotan, Murat Hasanreisoğlu, Michal Kramer, Yehudit Monselise, Yoram Cohen, Dov Weinberger, Nitza Goldenberg‐Cohen,
... a mouse model of anterior ischemic optic neuropathy (rAION). Methods: AION was induced in C57/BL6 mice ... Plasma: IL-6 levels were elevated immediately after rAION induction and decreased gradually thereafter. TNF-α showed ... may play a role in the pathogenesis of rAION.
Tópico(s): Angiogenesis and VEGF in Cancer
2008 - Taylor & Francis | Current Eye Research
Nitza Goldenberg‐Cohen, Yan Guo, Frank L. Margolis, Yoram Cohen, Neil R. Miller, Steven L. Bernstein,
... to characterize the timing of cells responding to rAION. The TUNEL assay detected cells undergoing apoptosis. Ultrastructural changes were analyzed by electron microscopy. results. In rAION, oligodendrocytes rapidly respond in vivo to ischemic ON ... death far from the primary lesion. conclusions. After rAION induction oligodendrocytes, as well as RGCs, undergo progressive ...
Tópico(s): Intraoperative Neuromonitoring and Anesthetic Effects
2005 - Cadmus Press | Investigative Ophthalmology & Visual Science
Bernard J. Slater, Fernandino L. Vilson, Yan Guo, Daniel Weinreich, Shelly Hwang, Steven L. Bernstein,
... after ON ischemia in the NAION rodent model (rAION). Methods.: Following rAION induction, GM-CSF was administered via intraventricular injection. ... RhoA activity, but did not neuroprotect RGCs after rAION. Conclusions.: Sudden ON ischemia results in previously unrecognized ...
Tópico(s): Neuroinflammation and Neurodegeneration Mechanisms
2013 - Cadmus Press | Investigative Ophthalmology & Visual Science
Rachael S Allen, Timothy W. Olsen, Iqbal Sayeed, Heather A. Cale, Katherine C. Morrison, Yuliya Oumarbaeva, Irina Lucaciu, Jeffrey H. Boatright, Machelle T. Pardue, Donald G. Stein,
... in rats: a rodent anterior ischemic optic neuropathy (rAION) model, which induces permanent monocular optic nerve stroke, ... and retinal ganglion cell loss in the permanent rAION model. In the transient MCAO model, progesterone treatment ... effects in the retina following MCAO but not rAION injury, which may result from mechanistic differences with ...
Tópico(s): Intraoperative Neuromonitoring and Anesthetic Effects
2015 - Cadmus Press | Investigative Ophthalmology & Visual Science
Allison C. White, Inga Saikkonen,
... titular ethnic minorities in Russia. We leverage unique raion-level electoral and demographic data in a series ... suggest that electoral turnout is consistently higher in raions with a higher share of titular minorities and ... in unexpected ways by contextual characteristics at the raion and regional levels.
Tópico(s): Religion and Society Interactions
2016 - Taylor & Francis | Ethnopolitics
... 27:4 (Spring 1994): 81–95. Kiriyama, Hideki. Raion Kingu’ Wa Tousaku Ka (Is The Lion King ... Tezuka Osamu?). Tokyo : Chikuma Shobo, Co. Ltd., 1992. “ Raion Kingu: ‘Janguru Taitei’ Ni Sutori Sokkuri (The Lion ... July 1994. “ Sukuriin Yori Saki CM De Katsuyaku ‘Raion Kingu’ Kyarakuta (The Lion King Characters Active on ...
Tópico(s): Asian Culture and Media Studies
1997 - Wiley | The Journal of Popular Culture
Yao‐Tseng Wen, Yu-Chieh Ho, Yueh-Chang Lee, Dah‐Ching Ding, Pei‐Kang Liu, Rong‐Kung Tsai,
... a rodent model of anterior ischemic optic neuropathy (rAION). The visual function, retinal ganglion cell (RGC) density, ... preserved the visual function and RGC density in rAION via inhibition of macrophage infiltration and RGC apoptosis. ... However, the MDCM provided the neuroprotective effects in rAION.
Tópico(s): Retinal and Optic Conditions
2021 - Multidisciplinary Digital Publishing Institute | International Journal of Molecular Sciences
Jia-Ying Chien, Shu-Fang Lin, Yu-Yau Chou, Chi‐Ying F. Huang, Shun‐Ping Huang,
... injury in an experimental anterior ischemic optic neuropathy (rAION) rat model induced by photothrombosis. Our results show ... modulated microglial polarization, and preserved visual function after rAION induction. OA activated nuclear factor E2 related factor ( ... retinal ganglion cells from ischemic injury, in the rAION model and could potentially be used as a ...
Tópico(s): Retinal and Optic Conditions
2021 - Multidisciplinary Digital Publishing Institute | Antioxidants