Sandrine Florquin, Kasper M.A. Rouschop,
... of TEC dominate the picture [25.Liu Y. Rajur K. Tolbert E. Dworkin L.D. Endogenous hepatocyte ... in rats with remnant kidneys [25.Liu Y. Rajur K. Tolbert E. Dworkin L.D. Endogenous hepatocyte ... Scholar], but Liu et al [25.Liu Y. Rajur K. Tolbert E. Dworkin L.D. Endogenous hepatocyte ... 2, resulting in matrix degradation [25.Liu Y. Rajur K. Tolbert E. Dworkin L.D. Endogenous hepatocyte ...
Tópico(s): Fibroblast Growth Factor Research
2003 - Elsevier BV | Kidney International
... transition (EMT) process under pathological conditions.10Liu Y Rajur K Tolbert E Dworkin LD Endogenous hepatocyte growth ... μm thickness using a routine procedure.10Liu Y Rajur K Tolbert E Dworkin LD Endogenous hepatocyte growth ... according to the method described previously.10Liu Y Rajur K Tolbert E Dworkin LD Endogenous hepatocyte growth ...
Tópico(s): Tissue Engineering and Regenerative Medicine
2001 - Elsevier BV | American Journal Of Pathology
Joan M. Mazzarelli, Sharanabasava B. Rajur, Patricia L. Iadarola, Larry W. McLaughlin,
... by base analog substitutionJoan M. Mazzarelli, Sharanabasava B. Rajur, Patricia L. Iadarola, and Larry W. McLaughlinCite this: ...
Tópico(s): Chronic Myeloid Leukemia Treatments
1992 - American Chemical Society | Biochemistry
Stacia M. Rink, Marjorie S. Solomon, Matthew J. Taylor, Sharanabasava B. Rajur, Larry W. McLaughlin, Paul B. Hopkins,
... Marjorie S. Solomon, Matthew J. Taylor, Sharanabasava B. Rajur, Larry W. McLaughlin, and Paul B. HopkinsCite this: ...
Tópico(s): DNA and Nucleic Acid Chemistry
1993 - American Chemical Society | Journal of the American Chemical Society
Dong Jing Fu, Sharanabasava B. Rajur, Larry W. McLaughlin,
... by a hammerhead ribozymeDong Jing Fu, Sharanabasava B. Rajur, and Larry W. McLaughlinCite this: Biochemistry 1993, 32, ...
Tópico(s): Genomics and Phylogenetic Studies
1993 - American Chemical Society | Biochemistry
Jordi Robles, Sharanabasava B. Rajur, Larry W. McLaughlin,
... Groove and Minor Groove BindingJordi Robles, Sharanabasava B. Rajur, and Larry W. McLaughlinView Author Information Department of ...
Tópico(s): DNA and Biological Computing
1996 - American Chemical Society | Journal of the American Chemical Society
Dong-jing Fu, Sharanabasava B. Rajur, Larry W. McLaughlin,
... the Guanosine 2'-HydroxylsDong-jing Fu, Sharanabasava B. Rajur, and Larry W. McLaughlinCite this: Biochemistry 1994, 33, ...
Tópico(s): Enzyme Structure and Function
1994 - American Chemical Society | Biochemistry
P. V. Kulkarni, Sharanabasava B. Rajur, Peter P. Antich, Tejraj M. Aminabhavi, Mrityunjaya I. Aralaguppi,
Abstract Modecular transport of drugs through carier polymeric materds has been an active area of research. A number of soluble polymers have been used to deliver the drugs selectively to specific parts of the body. The literature in this area of research is extensive and diverse. An effort has been made to review the transport of drug molecules through physiological systems via polymeric materials. A brief introduction to the fundamentals and concepts which are frequently used in the drug-delivery ...
Tópico(s): Pharmaceutical studies and practices
1990 - Taylor & Francis | Journal of Macromolecular Science Part C- Polymer Reviews
Marc Schleh, Peter Romanowski, Prince Bhebe, Li Zhang, Shivanthi Chinniah, B. Kay Lawrence, Houman Bashiri, Asri Gaduh, Viveka Rajurs, Brian Schou Rasmussen, Alice S. Chuck, Houman Dehghani,
Abstract Viral contaminations of biopharmaceutical manufacturing cell culture facilities are a significant threat and one for which having a risk mitigation strategy is highly desirable. High temperature, short time (HTST) mammalian cell media treatment may potentially safeguard manufacturing facilities from such contaminations. HTST is thought to inactivate virions by denaturing proteins of the viral capsid, and there is evidence that HTST provides ample virucidal efficacy against nonenveloped or ...
Tópico(s): Animal Virus Infections Studies
2009 - American Chemical Society | Biotechnology Progress
Sharanabasava B. Rajur, A. Y. MERWADE, L. D. Basanagoudar,
Abstract An easy synthesis of 3,5-disubstituted-2-actylindoles by the HC1 cyclization of the corresponding phenylhydrazones is described.
Tópico(s): Fluorine in Organic Chemistry
1992 - Taylor & Francis | Synthetic Communications
Sharanabasava B. Rajur, Larry W. McLaughlin,
A procedure is described for the Preparation of two thymidine analogues in which the O2-carbonyl is deleted (dH2T) or converted to an O2-thione (ds2T). The phosphoramidites of these nucleosides have been synthesized and used to incorporate the analogues site-specifically into oligodeoxynucleotide sequences.
Tópico(s): Genomics and Chromatin Dynamics
1992 - Elsevier BV | Tetrahedron Letters
Stephen A. Smith, Sharanabasava B. Rajur, Larry W. McLaughlin,
We have analysed the interaction of the trp repressor with the trpEDCBA operator using a series of modified trp operator sequences incorporating two isosteric purine analogues that lack N7-nitrogens. Our results suggest that as well as the direct contact between Arg69 and G-9, three additional purine N7-nitrogens, implicated in specific, water-mediated contacts to the repressor, are critical for formation of the high-affinity repressor-operator complex. We conclude that the crystal structure obtained ...
Tópico(s): Biochemical and Structural Characterization
1994 - Nature Portfolio | Nature Structural & Molecular Biology
Stephen A. Smith, Sharanabasava B. Rajur, Larry W. McLaughlin,
Tópico(s): Cellular transport and secretion
1994 - Nature Portfolio | Nature Structural & Molecular Biology
RavindraG Mali, RajuR Wadekar,
Tópico(s): Phytochemistry and Biological Activities
2008 - Medknow | International Journal of Green Pharmacy
Myrto Giannopoulou, Chunsun Dai, Xiaoyue Tan, Xiao‐Yan Wen, George K. Michalopoulos, Youhua Liu,
... 937-948PubMed Scopus (0) Google Scholar, 28Liu Y Rajur K Tolbert E Dworkin LD Endogenous hepatocyte growth ...
Tópico(s): Phagocytosis and Immune Regulation
2008 - Elsevier BV | American Journal Of Pathology
Bernardo Rodríguez‐Iturbe, Richard R. Johnson, Jaime Herrera-Acosta,
... fibrosis in the remnant kidney in rats52Liu Y. Rajur K. Tolbert E. Dworkin L.D. Endogenous hepatocyte ...
Tópico(s): Liver Disease and Transplantation
2005 - Elsevier BV | Kidney International
Kristin Wiederholt, Sharanabasava B. Rajur, John S. Giuliano, Maryanne J. O'Donnel, Larry W. McLaughlin,
Fluorescent Hoechst 33258 analogues have been synthesized in which the terminal phenol moiety is employed as a site for the introduction of a linker to permit covalent attachment of the fluorophores to oligo(deoxynucleotides). Hybridization by the DNA−Hoechst conjugates to target sequences generates the DNA minor groove structure and triggers a binding event by the tethered Hoechst agent. The attendant fluorescence signal reports upon this hybridization event. Conjugation of the Hoechst derivatives ...
Tópico(s): RNA Interference and Gene Delivery
1996 - American Chemical Society | Journal of the American Chemical Society
Youhua Liu, Krupa Rajur, Evelyn Tolbert, Lance D. Dworkin,
Endogenous hepatocyte growth factor ameliorates chronic renal injury by activating matrix degradation pathways.BackgroundHepatocyte growth factor (HGF) has been shown to promote tubule repair and renal regeneration following acute injury; however, whether HGF also modulates the development and progression of chronic renal diseases that are characterized by progressive tissue fibrosis is uncertain. To examine this question, this study investigated the functional consequence of blocking endogenous ...
Tópico(s): Organ Transplantation Techniques and Outcomes
2000 - Elsevier BV | Kidney International
Percy H. Carter, Thomas Dean, Brijesh Bhayana, Ashok Khatri, Raj Rajur, Thomas J. Gardella,
Abstract The parathyroid hormone receptor-1 (PTHR1) plays critical roles in regulating blood calcium levels and bone metabolism and is thus of interest for small-molecule ligand development. Of the few small-molecule ligands reported for the PTHR1, most are of low affinity, and none has a well-defined mechanism of action. Here, we show that SW106 and AH-3960, compounds previously identified to act as an antagonist and agonist, respectively, on the PTHR1, each bind to PTHR1-delNT, a PTHR1 construct ...
Tópico(s): Fibroblast Growth Factor Research
2015 - Oxford University Press | Molecular Endocrinology
Sri Mahavir Agarwal, Sridatta Rajur, Anushree Bose, Sonia Shenoy, Srikanth Miriyala, Venkataram Shivakumar, Harleen Chhabra, Janardhanan C. Narayanaswamy, Palanimuthu Thangaraju Sivakumar, Ganesan Venkatasubramanian,
Neuromodulatory interventions like transcranial direct current stimulation (tDCS) is emerging as a potential therapeutic strategy to promote cognitive function in healthy and pathological aging. There is need for more studies evaluating the utility and tolerability of tDCS in Mild cognitive impairment (MCI). Since MCI is considered as the prodromal stage of dementia, it has emerged as the most important target for intervention in dementia.This study investigated the feasibility, tolerability and clinical ...
Tópico(s): Neurobiology of Language and Bilingualism
2016 - Elsevier BV | Asian Journal of Psychiatry
Sharanabasava B. Rajur, Charles M. Roth, Jeffrey R. Morgan, Martin L. Yarmush,
Antisense oligonucleotides have been covalently attached to asialoglycoprotein (ASGP) via disulfide bond conjugation chemistry. These conjugates were characterized extensively by an array of chemical, chromatographic, and spectroscopic means. Multiple (approximately six) oligonucleotides can be conjugated to each ASGP molecule. The molecular conjugates were used to deliver antisense oligonucleotides complementary to the mRNA of the interleukin 6 signal transduction protein (gp130) to modulate the acute ...
Tópico(s): Electron Spin Resonance Studies
1997 - American Chemical Society | Bioconjugate Chemistry
Kristin Wiederholt, Sharanabasava B. Rajur, Larry W. McLaughlin,
A series of DNA conjugates have been prepared in which two different derivatives of Hoechst 33258 have been tethered to a sequence containing a 5'-GAATTC-3' target site. The two derivatives differ only in the length of the tether between the DNA and the Hoechst fluorophore. By using a DNA backbone labeling protocol, one in which the Hoechst dye is tethered to an internucleotide phosphoramidate residue, it was possible to easily vary the site of attachment with respect to the A-T rich binding site. ...
Tópico(s): RNA Interference and Gene Delivery
1997 - American Chemical Society | Bioconjugate Chemistry
Sharanabasava B. Rajur, Jordi Robles, Kristin Wiederholt, Robert G. Kuimelis, Larry W. McLaughlin,
A fluorescent Hoechst 33258 derivative has been prepared in which a hexa(ethylene glycol) linker is attached to the terminal phenol residue. Conjugation of this derivative to DNA sequences is accomplished by a reversed coupling protocol, one in which the 5‘-terminal nucleoside residue of a fully protected DNA sequence is converted to a terminal phosphoramidite. In the presence of the Hoechst derivative and tetrazole the final coupling reaction is achieved to generate the conjugated nucleic acid. ...
Tópico(s): Advanced biosensing and bioanalysis techniques
1997 - American Chemical Society | The Journal of Organic Chemistry
Sandhya Xirasagar, Matthew B. Elliott, Wilmin Bartolini, Paul Gollnick, Philip A. Gottlieb,
... PubMed Scopus (304) Google Scholar, 27Mazzarelli J.M. Rajur S.B. Ladarola P.L. McLaughlin L.W. ...
Tópico(s): Bacterial Genetics and Biotechnology
1998 - Elsevier BV | Journal of Biological Chemistry
... very high sulphur coal rejects from Taroda, Bellora, Rajur and New Majri (U/G) collieries in Wardha ...
Tópico(s): Mineral Processing and Grinding
2003 - Elsevier BV | Fuel Processing Technology
Sharanabasava B. Rajur, A. Y. MERWADE, L. D. Basanagoudar, Padmashree Kulkarni,
Ten new 4,8-disubstituted 10-methyl-1,2-dihydro-1-oxo-1,2,4-triazino(4,5-a)indoles (5 and 6) were prepared by refluxing various 5-substituted indole-2-carbohydrazides (4) with triethylorthoformate or triethylorthoacetate in dimethylformamide. These derivatives were evaluated for their antimicrobial activity. Some of the title compounds possess fairly potent antimicrobial activity.
Tópico(s): Synthesis and Reactions of Organic Compounds
1989 - Elsevier BV | Journal of Pharmaceutical Sciences
Sharanabasava B. Rajur, A. Y. MERWADE, L. D. Basanagoudar,
A series of novel 11-phenyl-2, 3, 4, 5-tetrahydro-1H-(1, 4)diazepino(1, 2-a)indoles (5a–f) and 1-(3-aminopropyl)-2-hydroxymethyl-3-phenylindoles (6a–f) are reported. The compounds (5a–f) were prepared by the lithium aluminum hydride (LAH) reduction of corresponding 11-phenyl-1H-1-oxo-2, 3, 4, 5-tetrahydro(1, 4)diazepino(1, 2-a)indoles (4a–f). The precursors (4a–f) were, in turn, prepared by the catalytic reduction of 1-(2-cyanpethyl)-3-phenylindole-2-carboxylates (2a–f) and cyclization of the resulting ...
Tópico(s): Phenothiazines and Benzothiazines Synthesis and Activities
1990 - Elsevier BV | Journal of Pharmaceutical Sciences
Charles M. Roth, Steven Reiken, Joseph M. Le Doux, Sharanabasava B. Rajur, Xiaoming Lu, Jeffrey R. Morgan, Martin L. Yarmush,
Antisense technology is potentially a powerful means by which to selectively control gene expression. We have used antisense oligonucleotides to modulate the response of the hepatoma cell line, HepG2, to the inflammatory cytokine, IL-6, by inhibiting the expression of its multifunctional signal transducer, gp130. HepG2 cells respond to IL-6 by upregulating acute phase proteins, such as haptoglobin, by five- to tenfold. Gp130 is central to this response, as the upregulation of haptoglobin is almost ...
Tópico(s): RNA Research and Splicing
1997 - Wiley | Biotechnology and Bioengineering
Shambabu Joseph Maddirala, Vidya S. Gokak, Sharanabasava B. Rajur, L. D. Basanagoudar,
Unlike the migration of a methyl group observed in the ZnCl2 or acetic acid-catalysed indolisation of phenylhydrazones, dry ethanolic HCl catalysed indolisation of 2,6-dimethyl- and 2,4,6-trimethylphenylhydrazones of various substituted butane-2,3-diones and ethyl pyruvates yields 7-methyl- and 5,7-dimethyl-3-substituted indoles indicating elimination of an ortho-methyl group during indolisation.
Tópico(s): Asymmetric Synthesis and Catalysis
2003 - Elsevier BV | Tetrahedron Letters
PrajaktaV Desai, RajuR Wadekar, GirishH Kedar, KalpanaS Patil,
Tópico(s): Phytochemistry and Biological Activities
2008 - Medknow | International Journal of Green Pharmacy