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Artigo Acesso aberto Revisado por pares

Elisabet Selga, Óscar Campuzano, Mel·lina Pinsach‐Abuin, Alexandra Pérez‐Serra, Irene Mademont‐Soler, Helena Riuró, Ferran Picó, Mónica Coll, Anna Iglesias, Sara Pagans, Geòrgia Sarquella-Brugada, Paola Berne, Begoña Benito, Josép Brugada, José Manuel Porres, M. López Zea, Víctor Castro‐Urda, Ignacio Fernández Lozano, Ramón Brugada,

Background Brugada syndrome (BrS) is a rare genetic cardiac arrhythmia that can lead to sudden cardiac death in patients with a structurally normal heart. Genetic variations in SCN5A can be identified in approximately 20-25% of BrS cases. The aim of our work was to determine the spectrum and prevalence of genetic variations in a Spanish cohort diagnosed with BrS. Methodology/Principal Findings We directly sequenced fourteen genes reported to be associated with BrS in 55 unrelated patients clinically ...

Tópico(s): RNA and protein synthesis mechanisms

2015 - Public Library of Science | PLoS ONE

Revisão Revisado por pares

José Antonio Carreño, José M. Llaneza, Luís Javier Alvarez, María Angeles Menéndez, José Rodríguez-Olay, Manuel Vallina, José Ignacio Fernández Fernández, Ramón Fernández, Lino Camblor, Jose María Gutiérrez,

A case of spontaneous acute infrarenal aortic dissection, with extension to the right common iliac artery and proximally to just below the origin of the renal arteries is presented. This dissection did not involve the visceral vessels nor the iliac system. The diagnosis was made with ultrasonography and computed tomography, without the need for angiography, and confirmed during surgical intervention, in which, prosthetic replacement of the affected segment was carried out.

Tópico(s): Infectious Aortic and Vascular Conditions

1998 - Elsevier BV | Annals of Vascular Surgery

Artigo Acesso aberto Revisado por pares

J. Fernández Ludeña, Esteban Álvarez Fresno, Roberto Secades‐Villa, J.M. Jiménez García, Álvaro Cañada Martínez, Ignacio Donate Suárez, José Ramón Fernández Hermida, G. Vallejo Seco,

The objective of this study is to analyze the situation of designer drug use in young people in Asturias (northern Spain), and to identify the variables related to the consumption of these substances. The sample was made up of 1597 students from secondary schools in this Autonomous Region. Results show that 8% of the young people interviewed had consumed designer drugs at some time, 7% had taken them during the previous year and 4.7% had used them during the previous 30 days. Prevalence of use increased ...

Tópico(s): Smoking Behavior and Cessation

2003 - | Adicciones

Artigo Revisado por pares

Enrique Vázquez-Sequeiros, Todd H. Baron, Manuel Pérez‐Miranda, Andrés Sánchez-Yagüe, Joan B. Gornals, Ferrán González-Húix, Carlos De La Serna, Juan Ángel Gónzalez Martín, Antonio Z. Gimeno–García, Carlos Marra-López, Ana Castellot, Fernando Alberca, Ignacio Fernández-Urién, José Ramón Aparicio, María Luisa Legaz, Oriol Sendino, Carme Loras, João Subtil, Juan P. Barret, M Pérez-Carreras, José Díaz-Tasende, Gustavo Pérez, Alejandro Repiso, Àngels Vilella, Carlos Dolz, A. del Cañizo Alvarez, Santiago Rodríguez, José Miguel Esteban López-Jamar, Diego Juzgado, Agustı́n Albillos,

Background and Aims Initial reports suggest that fully covered self-expandable metal stents (FCSEMSs) may be better suited for drainage of dense pancreatic fluid collections (PFCs), such as walled-off pancreatic necrosis. The primary aim was to analyze the effectiveness and safety of FCSEMSs for drainage of different types of PFCs in a large cohort. The secondary aim was to investigate which type of FCSEMS is superior. Methods This was a retrospective, noncomparative review of a nationwide database ...

Tópico(s): Gallbladder and Bile Duct Disorders

2016 - Elsevier BV | Gastrointestinal Endoscopy

Artigo Acesso aberto Revisado por pares

José Luís Merino, José Ramón Carmona, Ignacio Fernández Lozano, Rafaél Peinado, Nuria Basterra, José A. Sobrino,

Ventricular arrhythmias have been documented and linked to the high incidence of sudden death seen in patients with myotonic dystrophy. However, their precise mechanism is unknown, and their definitive therapy remains to be established.We studied 6 consecutive patients with myotonic dystrophy and sustained ventricular tachycardia by means of cardiac electrophysiological testing. Particular attention was paid to establish whether bundle-branch reentry was the tachycardia mechanism, and when such ...

Tópico(s): Neurological disorders and treatments

1998 - Lippincott Williams & Wilkins | Circulation

Artigo Acesso aberto

Noemí Merayo, David Juárez Varón, Juan Carlos Aguado, Ignacio de Miguel, Ramón J. Durán Barroso, Patricia Fernández, Rubén M. Lorenzo, Evaristo J. Abril,

In this paper, a proportional-integral-derivative (PID) controller integrated with a neural network (NN) is proposed to ensure quality of service (QoS) bandwidth requirements in passive optical networks (PONs). To the best of our knowledge, this is the first time an approach that implements a NN to tune a PID to deal with QoS in PONs is used. In contrast to other tuning techniques such as Ziegler–Nichols or genetic algorithms (GA), our proposal allows a real-time adjustment of the tuning parameters according ...

Tópico(s): Advanced Fiber Laser Technologies

2017 - | Journal of Optical Communications and Networking

Artigo Acesso aberto Revisado por pares

Noemí Merayo, Inés Ruíz Requies, Jorge Debrán, Juan Carlos Aguado, Ignacio de Miguel, Ramón J. Durán Barroso, Patricia Fernández, Rubén M. Lorenzo, Evaristo J. Abril,

Abstract We developed the responsive environment AIM‐Mobile Learning Platform, which permits to assess students using smartphones and to design online educational packets. We carried out a qualitative and quantitative study in Higher Education subjects using the case study and the triangulation data methods. Results demonstrated that the environment promotes a dynamic learning‐teaching process inside class, increasing the motivation, participation, and attention of students and helping them to be ...

Tópico(s): Educational Innovations and Technology

2018 - Wiley | Computer Applications in Engineering Education

Artigo Revisado por pares

Antonio Caballero, Robert Borkowski, Ignacio de Miguel, Ramón J. Durán Barroso, Juan Carlos Aguado, Patricia Fernández, Tamara Jiménez, Ignacio Rodríguez, David Sánchez, Rubén M. Lorenzo, Dimitrios Klonidis, Eleni Palkopoulou, Nikolaos-Panteleimon Diamantopoulos, Ioannis Tomkos, Domenico Siracusa, Antonio Francescon, Elio Salvadori, Yabin Ye, Jorge López Vizcaíno, Fabio Pittalà, Andrzej Tymecki, Idelfonso Tafur Monroy,

High degree of heterogeneity of future optical networks, stemming from provisioning of services with different quality-of-transmission requirements, and transmission links employing mixed modulation formats or switching techniques, will pose a challenge for the control and management of the network. The incorporation of cognitive techniques can help to optimize a network by employing mechanisms that can observe, act, learn and improve network performance, taking into account end-to-end goals. The ...

Tópico(s): Advanced Photonic Communication Systems

2014 - Institute of Electrical and Electronics Engineers | Journal of Lightwave Technology

Artigo Acesso aberto Revisado por pares

Isabel Jurado, J. M. Maestre, Pablo Velarde, Carlos Ocampo‐Martínez, Ignacio Fernández-Olmo, Beatriz Isla-Tejera, José Ramón Del Prado,

One of the most important problems in the pharmacy department of a hospital is stock management. The clinical need for drugs must be satisfied with limited work labor while minimizing the use of economic resources. The complexity of the problem resides in the random nature of the drug demand and the multiple constraints that must be taken into account in every decision. In this article, chance-constrained model predictive control is proposed to deal with this problem. The flexibility of model predictive ...

Tópico(s): Fault Detection and Control Systems

2015 - Elsevier BV | Computers in Biology and Medicine

Artigo Revisado por pares

A. de la Fuente, Arancha Urchaga, Ramón Sánchez, J Urman Fernández, Ignacio Moriones,

Aneurysm of the left atrial appendage (LAA) is very infrequent. We present the case of 24-year-old man in functional class I with atrial fibrillation but no other symptoms. Radiology showed an abnormality in the outline of the heart. Echocardiography revealed left appendage aneurysm. After median sternotomy, aneurysmectomy was performed under cardiopulmonary bypass without cross clamping. Atrial fibrillation ceased as soon as the aneurysm had been removed. There were no postoperative complications. ...

Tópico(s): Cardiac Arrhythmias and Treatments

2008 - Elsevier BV | The Annals of Thoracic Surgery

Artigo Acesso aberto Revisado por pares

Cristina Carretero, Miguel Muñoz‐Navas, Maite Betés, Ramón Angós, João Subtil, Ignacio Fernández-Urién, S. Riva, Josu Sola, José Ignacio Bilbao, Esther de Luis, Bruno Sangro,

Radioembolization is a new tool for the treatment of hepatic tumors that consists in the injection of biocompatible microspheres carrying radioisotopes into the hepatic artery or its branches.We have performed radioembolization in 78 patients with hepatic tumors using resin-based microspheres loaded with yttrium-90. All patients were previously evaluated to minimize the risk of hazardous irradiation to nontarget organs and to obtain the data needed for dose calculation.We report a complication found ...

Tópico(s): Pancreatic and Hepatic Oncology Research

2007 - Lippincott Williams & Wilkins | The American Journal of Gastroenterology

Artigo Acesso aberto Revisado por pares

Iván Carrera, Ignacio Etcheverrı́a, L. Fernández‐Novoa, Valter Lombardi, Ramón Cacabelos, Carmen Vigo,

A novel vaccine addressing the major hallmarks of Alzheimer's disease (AD), senile plaque-like deposits of amyloid beta-protein (Aβ), neurofibrillary tangle-like structures, and glial proinflammatory cytokines, has been developed. The present vaccine takes a new approach to circumvent failures of previous ones tested in mice and humans, including the Elan-Wyeth vaccine (AN1792), which caused massive T-cell activation, resulting in a meningoencephalitis-like reaction. The EB101 vaccine consists of Aβ( ...

Tópico(s): Immune Response and Inflammation

2012 - Hindawi Publishing Corporation | International Journal of Alzheimer s Disease

Artigo Revisado por pares

José Luís Calleja, J.M. Pascasio, Belén Ruíz‐Antorán, Francisco Gea, Rafael Bárcena, J.R. Larrubia, R. Pérez-Álvarez, J.M. Sousa, Manuel Romero‐Gómez, Ricard Solà, Juan de la Revilla, Javier Crespo, J.M. Navarro, Juan Ignacio Arenas, Manuel Delgado, Conrado Fernández-Rodrı́guez, Ramón Planas, Marı́a Buti, Xavier Forns,

The addition of protease inhibitors (PIs) changed the hepatitis C virus (HCV) treatment standards and improved sustained viral response (SVR) rates in patients with genotype 1 HCV infection.Prospective, multicentre, national registry that includes naïve and treatment-experienced patients with HCV genotype 1 infection, who had bridging fibrosis or cirrhosis and were treated with triple therapy (peginterferon alfa-2a or alfa-2b, ribavirin and boceprevir) as compassionate use, and in accordance with the ...

Tópico(s): Hepatitis B Virus Studies

2014 - Wiley | Liver International

Artigo

Ignacio de Miguel, Ramón J. Durán Barroso, Tamara Jiménez, Patricia Fernández, Juan Carlos Aguado, Rubén M. Lorenzo, Antonio Caballero, Idelfonso Tafur Monroy, Yabin Ye, Andrzej Tymecki, Ioannis Tomkos, Marianna Angelou, Dimitrios Klonidis, Antonio Francescon, Domenico Siracusa, Elio Salvadori,

The use of cognition is a promising element for the control of heterogeneous optical networks. Not only are cognitive networks able to sense current network conditions and act according to them, but they also take into account the knowledge acquired through past experiences; that is, they include learning with the aim of improving performance. In this paper, we review the fundamentals of cognitive networks and focus on their application to the optical networking area. In particular, a number of ...

Tópico(s): Advanced Photonic Communication Systems

2013 - | Journal of Optical Communications and Networking

Artigo Revisado por pares

A. de la Fuente, O. Agudo, Ramón Sánchez, Juan Luis Fernández Vega, Ignacio Moriones,

Rupture of the left ventricular wall is an infrequent but lethal complication after mitral valve replacement. We present the case of a patient in whom such a rupture was successfully repaired in the intensive care unit with a patch of Teflon felt stuck in place with glue.

Tópico(s): Cardiac pacing and defibrillation studies

1999 - Elsevier BV | The Annals of Thoracic Surgery

Artigo Acesso aberto Revisado por pares

Alberto M. Borobia, Sergio García Collado, César Carballo Cardona, Rosa Capilla Pueyo, Cesáreo Fernández Alonso, Ignacio Pérez Torres, María Corell González, José Ramón Casal Codesido, María Arranz Betegón, Luis Amador Barcela, Aitor Odiaga Andicoechea, Anselma Fernández Testa, Jorge Colina, Antonio Cid Dorribo, Carmen del Arco, José Carlos Martínez Ávila, Susana Traseira Lugilde, Antonio J. Carcas, Claudio Bueno Marisca, P. Mesa Rodríguez, Emilio Montero Romero, José Lázaro González, María A. Jañez Álvarez, Roberto Rodríguez Alonso, Javier del Castillo Nos, Manuel V. Duran Ruiz, Pere Llorens Soriano, Wilkins Poy, Luis Sánchez Cervera de los Santos, Fátima Barcala del Caño, Ángela Dopico García, Paula Núñez Gaviño, Elena Sánchez Fernández Linares, Jose Valle Cruz, Norma B. Sanz Cadenas, Maite Ayuso Aragonés, Lubna Dani, Olga González Peña, María M. Jaén Cañadas, Mikel Rico Briñas, Yale Tung Cheng, Isabel López Isidro, Laura Ferrer Armengou, Paula Molina Ávila, Amaia Etxebarria Gulías, Kristina García Lombardía, Patricia Wunderling Brüggenmann,

Study objectiveThe objective of the InMEDIATE study was to evaluate the change in intensity of traumatic pain over the first 20 min in adult patients treated with methoxyflurane versus standard analgesic treatment in Spain. This the first randomized, active-controlled, multicenter trial of methoxyflurane in the emergency setting in Europe.MethodsThis was a randomized, controlled study that enrolled adult patients with acute moderate to severe (score ≥4 on the 11-point Numeric Rating Scale) trauma- ...

Tópico(s): Anesthesia and Pain Management

2019 - Elsevier BV | Annals of Emergency Medicine

Artigo

Juan B. López Messa, José Ignacio Alonso Fernandez, Jesús María Andrés de Llano, José Ramón Garmendia-Leiza, Julio Ardura Fernández, Flor de Castro Rodríguez, Juan Manuel Gil González,

Objetivo: Analizar las caracteristicas generales de la parada cardiaca extrahospitalaria (PCEH) en una comunidad autonoma y los factores asociados a la recuperacion de la circulacion espontanea (RCE). Metodo: Estudio descriptivo retrospectivo de las PCEH de origen cardiaco incluidas en la base de datos del servicio de emergencias (SEM) de Castilla y Leon en un periodo de 18 meses. El objetivo primario fue la RCE. Las variables analizadas fueron la edad, sexo, ritmo desfibrilable (DF), lugar del paro, ...

Tópico(s): Emergency and Acute Care Studies

2012 - Spanish Society of Emergency Medicine | Emergencias

Artigo Acesso aberto Revisado por pares

Ignacio Aznar‐Lou, Ana Fernández, Montserrat Gil‐Girbau, Ramón Sabés-Figuera, Marta Fajó‐Pascual, Maria Teresa Peñarrubia‐María, Antoni Serrano‐Blanco, Patrícia Moreno-Peral, Albert Sánchez‐Niubò, Marian March-Pujol, María Rubio-Valera,

Background Initial medication non-adherence is highly prevalent in primary care but no previous studies have evaluated its impact on the use of healthcare services and/or days on sick leave. Aim To estimate the impact of initial medication non-adherence on the use of healthcare services, days of sick leave, and costs overall and in specific medication groups. Design and setting A 3-year longitudinal register-based study of all primary care patients (a cohort of 1.7 million) who were prescribed a ...

Tópico(s): Pharmaceutical studies and practices

2017 - Royal College of General Practitioners | British Journal of General Practice

Artigo Revisado por pares

Noemí Merayo, Tamara Jiménez, Ramón J. Durán Barroso, Patricia Fernández, Ignacio de Miguel, Rubén M. Lorenzo, Evaristo J. Abril,

Tópico(s): Advanced Optical Network Technologies

2009 - Springer Science+Business Media | Photonic Network Communications

Artigo Revisado por pares

F. Gil-Ortiz, Santiago Ramón‐Maiques, M. Leonor Fernández‐Murga, Ignacio Fita, Vicente Rubio,

N-Acetyl-l-glutamate kinase (NAGK), the paradigm enzyme of the amino acid kinase family, catalyzes the second step of arginine biosynthesis. Although substrate binding and catalysis were clarified by the determination of four crystal structures of the homodimeric Escherichia coli enzyme (EcNAGK), we now determine 2 Å resolution crystal structures of EcNAGK free from substrates or complexed with the product N-acetyl-l-glutamyl-5-phosphate (NAGP) and with sulfate, which reveal a novel, very open NAGK ...

Tópico(s): Amino Acid Enzymes and Metabolism

2010 - Elsevier BV | Journal of Molecular Biology

Artigo Revisado por pares

Ramón Ramos‐Ríos, Manuel Arrojo, Eduardo Paz-Silva, Fernando Carballal-Calvo, José L. Bouzón-Barreiro, Jorge Seoane-Prado, Rosario Codesido-Barcala, Alicia Crespí-Armenteros, Ramón Fernández-Pérez, Javier-David López-Moríñigo, Ignacio Tortajada-Bonaselt, Francisco J. Díaz, José de León,

This naturalistic study attempted to determine the prevalence of prolonged QTc interval in a relatively large population of inpatients hospitalized with chronic schizophrenia, and to explore QTc relationship with demographic variables, metabolic parameters and prescribed treatments. All inpatients from a Spanish long-term psychiatric hospital were cross-sectionally investigated to determine the prevalence of QTc prolongation and metabolic syndrome. The sample with a DSM-IV diagnosis of schizophrenia ...

Tópico(s): Receptor Mechanisms and Signaling

2009 - Elsevier BV | Schizophrenia Research

Artigo Revisado por pares

Valter Lombardi, L. Fernández‐Novoa, Ignacio Etcheverrı́a, Silvia Seoane, Ramón Cacabelos,

Alzheimer's disease (AD) is the most prevalent neurodegenerative disorder, characterized by progressive impairment of cognitive functions. AD has a strong and complex genetic etiology, and multiple genes, acting independently and/or interacting, likely to influence the risk of developing AD. To test whether the expression of Fas receptor is upregulated in peripheral blood T lymphocytes and whether or not it correlates with APOE genotypes, 88 patients with AD and 24 normal individuals as controls ...

Tópico(s): Aluminum toxicity and tolerance in plants and animals

2004 - Thomson Reuters | Methods and Findings in Experimental and Clinical Pharmacology

Carta Acesso aberto Revisado por pares

Katrin Beyer, José Ignacio Lao-Villadóniga, B Vecino-Bilbao, Ramón Cacabelos, Raäl de la Fuente-Fernández.,

study is a result of a sampling bias.The patients in this study represent a series of admissions to a rehabilitation unit-where the referral of patients with right hemi- spheric lesions is most common when it involves the obvious and remediable signs of left hemiparesis and hemispatial neglect.It is likely that those such as the patient of Solms et al,7 whose bilateral frontal pathology was largely asymptomatic in the standard neuro- logical and neuropsychological examination, would never have been ...

Tópico(s): Neurological and metabolic disorders

1997 - BMJ | Journal of Neurology Neurosurgery & Psychiatry

Artigo

Tamara Jiménez, Noemí Merayo, Patricia Fernández, Ramón J. Durán Barroso, Ignacio de Miguel, Rubén M. Lorenzo, Evaristo J. Abril,

In this paper a proportional–integral–derivative (PID) controller to efficiently allocate bandwidth in high coverage passive optical networks (PONs) is presented. The novelty of this proposal relies on the fact that this is the first proposal to use a PID to control a network parameter in PONs. As the PID takes into account present, past and possible future errors in the bandwidth adjustment, this self-adapting technique results in a very robust process. Simulation results exhibit that not only is ...

Tópico(s): Advanced Fiber Laser Technologies

2012 - | Journal of Optical Communications and Networking

Artigo Acesso aberto Revisado por pares

Anna Tarradas, Elisabet Selga, Pedro Beltrán-Álvarez, Alexandra Pérez‐Serra, Helena Riuró, Ferran Picó, Anna Iglesias, Óscar Campuzano, Víctor Castro‐Urda, Ignacio Fernández Lozano, Guillermo J. Pérez, Fabiana S. Scornik, Ramón Brugada,

Brugada syndrome (BrS) is a life-threatening, inherited arrhythmogenic syndrome associated with autosomal dominant mutations in SCN5A, the gene encoding the cardiac Na+ channel alpha subunit (Nav1.5). The aim of this work was to characterize the functional alterations caused by a novel SCN5A mutation, I890T, and thus establish whether this mutation is associated with BrS. The mutation was identified by direct sequencing of SCN5A from the proband's DNA. Wild-type (WT) or I890T Nav1.5 channels were heterologously ...

Tópico(s): Neuroscience and Neural Engineering

2013 - Public Library of Science | PLoS ONE

Capítulo de livro Acesso aberto Revisado por pares

José Antonio Iglesias, Juan Antonio Fernández, Ignacio Ramon Villena, Agapito Ledezma, Araceli Sanchis,

Opponent modeling is a skill in multi-agent systems (MAS) which attempts to create a model of the behavior of the opponent. This model can be used to predict the future actions of the opponent and generate appropriate strategies to play against it. Several researches present different methods to create an opponent model in the RoboCup environment. However, how these models can impact the performance of teams is an essential aspect. This paper introduces a novel approach to use efficiently opponent ...

Tópico(s): Software Engineering Research

2009 - Springer Science+Business Media | Lecture notes in computer science

Artigo

Andrea Dalla Chiara, Giacomo Da Broi, Oscar Pozzobon, Silvia Sturaro, Gianluca Caparra, Nicola Laurenti, Javier Fidalgo, Miguel Ángel Bermúdez Odriozola, Jos� Caro Ramon, Ignacio Fernández‐Hernández, Eric Châtre,

The main focus of Satellite-Based Augmentation Systems has been the provision of integrity to the GNSS signals. However, the sensibility towards interference is growing within the GNSS community, as it becomes day by day more realistic, more feasible and cheaper. The purpose of this paper is to present a framework for designing SBAS authentication and to present innovative solutions. The paper will initially outline the threats to be mitigated, with emphasis on those specific to SBAS. The work will ...

Tópico(s): IoT Networks and Protocols

2016 - | Proceedings of the Satellite Division's International Technical Meeting (Online)/Proceedings of the Satellite Division's International Technical Meeting (CD-ROM)

Artigo Revisado por pares

Tamara Jiménez, Juan Carlos Aguado, Ignacio de Miguel, Ramón J. Durán Barroso, Marianna Angelou, Noemí Merayo, Patricia Fernández, Rubén M. Lorenzo, Ioannis Tomkos, Evaristo J. Abril,

We propose a cognitive Quality of Transmission (QoT) estimator for classifying lightpaths into high or low quality categories in impairment-aware wavelength-routed optical networks. The technique is based on Case-Based Reasoning (CBR), an artificial intelligence technique which solves new problems by exploiting previous experiences, which are stored on a knowledge base. We also show that by including learning and forgetting techniques, the underlying knowledge base can be optimized, thus leading to ...

Tópico(s): Advanced Photonic Communication Systems

2013 - Institute of Electrical and Electronics Engineers | Journal of Lightwave Technology