... 432 Euthanasia in Spain: The Public Debate after Ramon Sampedro’s Case María José Guerra, María José Guerra ...
Tópico(s): Ethics in medical practice
1999 - Wiley | Bioethics
Pablo Simón-Lorda, Inés María Barrio-Cantalejo,
... antecedentes del debate, con casos como los de Ramón Sampedro, Jorge León o Madeleine Z. Luego se presentan ... in Spain in cases such as those of Ramon Sampedro, Jorge Leon or Madeleine Z. It then presents ...
Tópico(s): Palliative Care and End-of-Life Issues
2008 - Elsevier BV | Medicina Intensiva
J. F. Solsona, Glòria Miró, Lluís Cabré, Montse Ferrer, Antoní Torres,
... antecedentes del debate, con casos como los de Ramón Sampedro, Jorge León o Madeleine Z. Luego se presentan ... in Spain in cases such as those of Ramon Sampedro, Jorge Leon or Madeleine Z. It then presents ...
Tópico(s): Family and Patient Care in Intensive Care Units
2001 - Elsevier BV | Archivos de Bronconeumología
José Luis Sánchez-López, Martín Molina, Hriday Bavle, Carlos Sampedro, Ramón A. Suárez Fernández, Pascual Campoy,
To achieve fully autonomous operation for Unmanned Aerial Systems (UAS) it is necessary to integrate multiple and heterogeneous technical solutions (e.g., control-based methods, computer vision methods, automated planning, coordination algorithms, etc.). The combination of such methods in an operational system is a technical challenge that requires efficient architectural solutions. In a robotic engineering context, where productivity is important, it is also important to minimize the effort for the ...
Tópico(s): UAV Applications and Optimization
2017 - Springer Science+Business Media | Journal of Intelligent & Robotic Systems
Nuria De Diego, Iñigo Saiz‐Fernández, J. L. Rodríguez, P. Pérez-Alfocea, M. Carmen Sampedro, Ramón J. Barrio, Maite Lacuesta, Paloma Moncaleán,
Studies of metabolic and physiological bases of plant tolerance and hardening against drought are essential to improve genetic breeding programs, especially in productive species such as Pinus radiata. The exposure to different drought cycles is a highly effective tool that improves plant conditioning, but limited information is available about the mechanisms that modulate this process. To clarify this issue, six P. radiata breeds with well-known differences in drought tolerance were analyzed after ...
Tópico(s): Allelopathy and phytotoxic interactions
2015 - Elsevier BV | Journal of Plant Physiology
Nuria De Diego, M. Carmen Sampedro, Ramón J. Barrio, Iñigo Saiz‐Fernández, Paloma Moncaleán, Maite Lacuesta,
Drought is one of the main abiotic factors that determine forest species growth, survival and productivity. For this reason, knowledge of plant drought response and the identification of physiological traits involved in stress tolerance will be of interest to breeding programs. In this work, several Pinus radiata D. Don breeds from different geographical origins were evaluated along a water stress period (4 weeks) and subsequent rewatering (1 week), showing different responses among them. Leaf water ...
Tópico(s): Allelopathy and phytotoxic interactions
2013 - Oxford University Press | Tree Physiology
X.A. Alvarez, Carolina Sampedro, Ramón Cacabelos, Carlos Sánchez‐Linares, Manuel Aleixandre, Manuel García-Fantini, Herbert Moessler,
According to current scientific knowledge, excess tumour necrosis factor-α (TNF-α) and low insulin-like growth factor-I (IGF-I) are pathogenic-risk factors that constitute therapeutic targets for Alzheimer's disease (AD). Changes in serum TNF-α, total and dissociable IGF-I levels were determined by ELISA in 207 AD patients completing a 24-wk, double-blind, placebo-controlled trial to evaluate the effects of the neurotrophic compound Cerebrolysin (Cere: 10, 30 or 60 ml for 12 wk). At week 24, Cere reduced ...
Tópico(s): Neurological Disease Mechanisms and Treatments
2009 - University of Oxford | The International Journal of Neuropsychopharmacology
Manuel Nieto‐Sampedro, Ramón Lim, Danny J. Hicklin, Carl W. Cotman,
A major component of the healing response of the brain to injury is the induction of growth and trophic factors. In the rat brain, glia maturation factor (GMF) and acidic fibroblast growth factor (aFGF) are not extracellular. However, within the first hour following brain injury, the amount of GMF and aFGF in the wound cavity increased by 7- and 13-fold, respectively, compared to the tissue adjacent to the wound. A cascade of cellular and biochemical events, leading to glial proliferation, the arrest ...
Tópico(s): Virus-based gene therapy research
1988 - Elsevier BV | Neuroscience Letters
Iván Carrera, L. Fernández‐Novoa, Carolina Sampedro, Ramón Cacabelos,
Parkinsonian-like state was generated in mice by the administration of 1-methyl-4-phenyl-1,2,3,6- tetrahydropyridine (MPTP) to study the effects of Atremorine in Parkinson's disease (PD) related neuropathology and behavior deficits. This devastating disease is caused by the progressive degeneration of dopaminergic neurons in the substantia nigra. Numerous therapeutic strategies have been developed to protect neuronal damage, although no effective treatment for PD has been validated yet. This study ...
Tópico(s): Parkinson's Disease Mechanisms and Treatments
2017 - Bentham Science Publishers | Current Pharmaceutical Design
Andrea Horta‐Barba, Javier Pagonabarraga, Saül Martínez‐Horta, Juan Marín‐Lahoz, Frederic Sampedro, Ramón Fernández de Bobadilla, María Ángeles Boti, Helena Bejr‐Kasem, Ignacio Aracil‐Bolaños, Jesús Pérez‐Pérez, Berta Pascual‐Sedano, Antònia Campolongo, Cristina Izquierdo, Beatriz Gómez‐Ansón, Jaime Kulisevsky,
Introduction: Memory alterations are common in Parkinson´s disease (PD) patients but the mechanisms involved in these deficits remain poorly understood. The study aims to explore the profile of episodic memory deficits in non-demented early PD patients. Methods: We obtained neurological, cognitive and behavioural data from 114 PD patients and 41 healthy controls (HC). PD participants were grouped as normal cognition (PD-NC) and mild cognitive impairment (PD-MCI) according to the Level II criteria of ...
Tópico(s): Dementia and Cognitive Impairment Research
2020 - Frontiers Media | Frontiers in Neurology
Martín Cuesta, Manuel Fuentes, Miguel A. Rubio, Elena Bordiú, Ana Barabash, Nuria García de la Torre, Gemma Rojo‐Martínez, Sergio Valdés, Federico Soriguer, Joan Vendrell, Inés Urrutia, Emilio Ortega, Eduard Montanya, Eldelmiro Menéndez, Ana Lago‐Sampedro, Ramón Gomis, Albert Goday, Conxa Castell, Rocío Badía-Guillén, J. Girbés, Sonia Gaztambide, Josep Franch‐Nadal, Elías Delgado, Felipe J. Chaves, Luís Castaño, Alfonso Calle-Pascual,
Introduction Metabolic syndrome (MetS) is an important predictor of cardiovascular mortality. Identification of occurrence and regression trends of MetS could permit elaboration of preventive strategies with new targets. The objective of this study was to analyze the occurrence and regression rates of MetS and its associated factors in the representative cohort of Spain of the di@bet.es study. Research design and methods The di@bet.es study is a prospective cohort where 5072 people representative ...
Tópico(s): Obesity, Physical Activity, Diet
2020 - BMJ | BMJ Open Diabetes Research & Care
O. López de Sabando, Zuriñe Gómez de Balugera, M. Aránzazu Goicolea, Esther Rodríguez, M. Carmen Sampedro, Ramón J. Barrio,
Tópico(s): Electrochemical sensors and biosensors
2002 - Springer Science+Business Media | Chromatographia
... The Sea Inside, 2004) portrays the life of Ramon Sampedro, a quadriplegic proeuthanasia activist. Both films treat disability ...
Tópico(s): Spanish Culture and Identity
2010 - Liverpool University Press | Journal of Literary & Cultural Disability Studies
Francesc Casellas, J Vivancos, Manuela Josefa Sampedro, Juan‐Ramón Malagelada,
BACKGROUND Crohn's disease (CD) has a negative impact on patients' perception of health. Several factors, such as disease activity, influence HRQOL impairment. However, the effect of the phenotypic CD characteristics recognized in the Vienna classification on health-related quality of life (HRQoL) remains unknown. METHODS HRQOL was measured in CD patients using three questionnaires: the Spanish version of the Inflammatory Bowel Disease Questionnaire (IBDQ-36), the Psychological General Well-Being Index ( ...
Tópico(s): Autoimmune and Inflammatory Disorders
2005 - Lippincott Williams & Wilkins | The American Journal of Gastroenterology
Tópico(s): Ethics and bioethics in healthcare
2004 - RELX Group (Netherlands) | SSRN Electronic Journal
Valter Lombardi, A.M. Martínez Cagiao, L. Fernández‐Novoa, XOSÉ ANTÓN ALVAREZ, Marı́a D. Corzo, R. Zas, Carolina Sampedro, Ramón Cacabelos,
There is emerging evidence that PUFAs influence immune functions by controlling the normal inflammatory process and may do so by serving as a signal modulator that regulates specific enzymatic activities typically elevated during inflammation at the inflammation site. In the present study, the effect of 12 weeks food supplementation with E-SAR 94010, a marine fish extract, before and during pregnancy and lactation in Sprague-Dawley rats and their offspring was investigated. Triglyceride plasma levels ...
Tópico(s): Immune Response and Inflammation
2001 - Elsevier BV | Nutrition Research
Belén Álvarez Álvarez, Charigán Abou Jokh Casas, Alberto Cordero, Álvaro Martínez Gómez, Ana Belén Cid Álvarez, Rosa Agra Bermejo, José Marı́a Garcı́a-Acuña, Francisco Gude Sampedro, José Ramón González‐Juanatey,
This study sought to analyze the association of early coronary angiography with all-cause mortality and cardiovascular mortality in patients with non–ST-segment elevation acute coronary syndrome (NSTEACS) using a large contemporary cohort of patients with NSTEACS from 2 Spanish tertiary hospitals. This retrospective observational study included 5673 consecutive NSTEACS patients from 2 Spanish hospitals between 2005 and 2016. We performed propensity score matching to obtain a well-balanced subset ...
Tópico(s): Cardiac Imaging and Diagnostics
2019 - Elsevier BV | Revista Española de Cardiología (English Edition)
Antonio Tornero-Martínez, Maria‐del‐Carmen Silva‐Lucero, Edén Cano Sampedro, Eva Ramón‐Gallegos, Claudia Pérez-Cruz, Brenda Pérez-Grijalva, Rosalva Mora‐Escobedo,
Tópico(s): Bioactive Compounds and Antitumor Agents
2022 - Springer Science+Business Media | Plant Foods for Human Nutrition
Pablo Simón-Lorda, Inés Ma Barrio-Cantalejo,
... after 2002. The debate increased significantly after the Ramon Sampedro case (1995-1998), and was fuelled with new, ...
Tópico(s): Grief, Bereavement, and Mental Health
2012 - Brill | European Journal of Health Law
... focuses on the death six years ago of Ramon Sampedro, a sailor who became quadriplegic after injuries sustained ...
Tópico(s): Kierkegaardian Philosophy and Influence
2004 - BMJ | BMJ
Belén Álvarez Álvarez, Charigán Abou Jokh Casas, José Marı́a Garcı́a-Acuña, Belén Cid Álvarez, Rosa María Agra Bermejo, Alberto Cordero, Moisés Rodríguez‐Mañero, Francisco Gude Sampedro, José Ramón González‐Juanatey,
•NSTEMI management has evolved over time due to early reperfusion and medical therapy. •Temporal changes in treatments and long-term outcomes were shown over the years. •The temporary trend is independent of the GRACE risk.
Tópico(s): Antiplatelet Therapy and Cardiovascular Diseases
2018 - Elsevier BV | International Journal of Cardiology
X.A. Alvarez, Carolina Sampedro, Rafael Lozano, Ramón Cacabelos,
Citicoline is an endogenous intermediate involved in the biosynthesis of brain phospholipids and acetylcholine which has been extensively used for the treatment of several neurodegenerative conditions. The effects of citicoline on neurodegeneration, apoptosis and learning were investigated in male Sprague Dawley rats subjected to implants of the beta-amyloid fragment 1-40 (A beta 4: 3 Mmol) into the right hippocampus and to permanent unilateral occlusion of the carotid artery. Citicoline (CDP; 0, ...
Tópico(s): Flavonoids in Medical Research
1999 - Thomson Reuters | Methods and Findings in Experimental and Clinical Pharmacology
Saül Martínez‐Horta, Frederic Sampedro, Javier Pagonabarraga, Ramón Fernández de Bobadilla, Juan Marín‐Lahoz, Jordi Riba, Jaime Kulisevsky,
Tópico(s): Transcranial Magnetic Stimulation Studies
2016 - Springer Science+Business Media | Brain Imaging and Behavior
Belén Álvarez Álvarez, Charigán Abou Jokh Casas, Alberto Cordero, Álvaro Martínez Gómez, Ana Belén Cid Álvarez, Rosa Agra Bermejo, José Marı́a Garcı́a-Acuña, Francisco Gude Sampedro, José Ramón González‐Juanatey,
Resumen Introduccion y objetivos El objetivo de este estudio es analizar la asociacion de la coronariografia precoz con la mortalidad por cualquier causa y la mortalidad cardiovascular en los pacientes con sindrome coronario agudo sin elevacion del segmento ST (SCASEST) utilizando una gran cohorte contemporanea de pacientes con SCASEST de 2 hospitales terciarios espanoles. Metodos Este estudio observacional retrospectivo incluyo a 5.673 pacientes con SCASEST consecutivos de 2 hospitales espanoles ...
Tópico(s): Coronary Interventions and Diagnostics
2019 - Elsevier BV | Revista Española de Cardiología
Silvia Millán‐Martín, M. Aránzazu Goicolea, A. Sánchez, Alberto Gómez‐Caballero, M. Carmen Sampedro, Nora Unceta, Ramón J. Barrio,
Abstract A rapid and sensitive HPLC enantioselective method with fluorescence detection was developed to determine (−)‐( R ) and (+)‐( S ) enantiomers of the metabolites of citalopram, demethyl‐ and didemethyl‐citalopram in plasma and brain tissue. This assay involves pre‐column chiral derivatization with (−)‐( R )‐1‐(1‐naphthyl)ethyl isocyanate followed by separation on a normal‐phase silica column. The developed liquid–liquid extraction procedure permits quantitative determination of analytes with recoveries ranged between ...
Tópico(s): Analytical Methods in Pharmaceuticals
2007 - Wiley | Biomedical Chromatography
Gemma Rojo‐Martínez, Sergio Valdés, Federico Soriguer, Joan Vendrell, Inés Urrutia, Vidal Pérez, Emilio Ortega, P. Ocón, Eduard Montanya, Edelmiro Menéndez Torre, Ana Lago‐Sampedro, T. González- Frutos, Ramón Gomis, Albert Goday, Sara García‐Serrano, Eva García‐Escobar, José Luis Galán–García, Conxa Castell, Rocío Badía-Guillén, Gabriel Aguilera‐Venegas, J. Girbés, Sonia Gaztambide, Josep Franch‐Nadal, Elías Delgado, Felipe J. Chaves, Luís Castaño, Alfonso L. Calle‐Pascual,
Our aim was to determine the incidence of type 2 diabetes mellitus in a nation-wide population based cohort from Spain (di@bet.es study). The target was the Spanish population. In total 5072 people older than 18 years,were randomly selected from all over Spain). Socio-demographic and clinical data, survey on habits (physical activity and food consumption) and weight, height, waist, hip and blood pressure were recorder. A fasting blood draw and an oral glucose tolerance test were performed. Determinations ...
Tópico(s): Nutritional Studies and Diet
2020 - Nature Portfolio | Scientific Reports
Olatz Baroja, Nora Unceta, M. Carmen Sampedro, M. Aránzazu Goicolea, Ramón J. Barrio,
An analytical methodology using thermal-desorption cold trap (TCT) and GC-MS was developed for the determination of the insecticide fenitrothion and its main metabolites, 3-methyl-4-nitrophenol and fenitrooxon, in forestry atmospheres. The sampled atmosphere was pumped through a glass tube containing 100 mg of Tenax adsorbent at a flow rate of 50 ml min(-1). Adsorption/thermal desorption and breakthrough experiments were performed to test the ability to quantitatively trap the compounds. The detection ...
Tópico(s): Insect and Pesticide Research
2004 - Elsevier BV | Journal of Chromatography A
Susana de Irazu, Nora Unceta, M. Carmen Sampedro, M. Aránzazu Goicolea, Ramón J. Barrio,
An electrochemical sensor for the determination of serotonin in urine was prepared using Ni(II)–phthalocyanine and Nafion to modify the surface of a 4 mm length carbon fiber microelectrode. The resultant sensor was found to improve the response towards this neuronal amine versus the microelectrode without the polymer films. Different polymerization conditions, as well as different conditioning solutions and buffer systems, were investigated in order to optimize the response of the electrodes. Square ...
Tópico(s): Analytical Chemistry and Sensors
2001 - Royal Society of Chemistry | The Analyst
P. Mendes-Ferreira, C. Maia-Rocha, Rui Adão, Ana Paula Lourenço, Clícia Grazielly de Lima Moura, Sirlaine de Pinho, J. C. Areias, Gilles W. De Keulenaer, Adelino Leite‐Moreira, C. Bras-Silva, Luise Holzhauser, D. Lindner, Anika Jenke, Heinz‐Peter Schultheiß, Diedrich Westermann, Carsten Skurk, T. Misaka, S. Suzuki, M Miyata, Akio Kobayashi, S. Saitoh, Yasuchika Takeishi, M. Czolbe, V. Pekarek, Trevor Williams, F. Panther, J. Strassen, Oliver Ritter, Stefan Voß, Holger Nef, S. Szardien, C. Troidl, B. Kojonazarov, D. Visser, J Hoffmann, M. Willmer, C. Hamm, H. Moellmann, Suzana Ljubojević, S. Sedej, M. Sacherer, G. Leitinger, J. Kockskaemper, Burkert Pieske, N. M. Vorobyeva, A. B. Dobrovolsky, E. V. Titaeva, A. I. Kirienko, Е. П. Панченко, R. Nakamura, Yuya Matsue, Akiko Mizukami, M. Ohno, M. Suzuki, Akira Matsumura, Yasuhiro Hashimoto, M. Rosiak, Marek Postuła, Agnieszka Kapłon‐Cieślicka, E. Trzepla, A. Czlonkowski, Krzysztof J. Filipiak, Grzegorz Opolski, Dariusz A. Kosior, Tommy Andersson, Pola Nagy, Maha Niazi, S. Nylander, Lars Wallentin, Joshua T. Mendell, Lee J Johnson, Glyneva Bradley Ridout, Longtao He, S. Chen, M. Petrkova, P. Schneiderova, E. Kriegova, Zdeněk Kolář, Miloš Táborský, Martin Petřek, N. Khuseyinova, Renate B. Schnabel, Thomas Zeller, Tommaso Gori, A. Schulz, Christine Espinola‐Klein, K Lackner, Stefan Blankenberg, T. Muenzel, P. S. Wild, Nicolas Amabile, SiMin Cheng, M. G. Larson, A. Ghorbani, E. Mc Cabe, G. Griffin, K. S. Cohen, A. Tedgui, Carole Boulanger, T. J. Wang, Marish I.F.J. Oerlemans, A. Mosterd, Mireille Dekker, E. A. De Vrey, Annette H M van der Helm–van Mil, Gerard Pasterkamp, Pieter A. Doevendans, A. W. Hoes, Joost P. G. Sluijter, C. Besler, Raisa Laaksonen, K. Ekroos, K. Tarasov, R. Hurme, T. F. Luescher, Arnold von Eckardstein, Ulf Landmesser, M. Ohno, Shaw Watanabe, Y. Hiraoka, Tatsuomi Matsuoka, Kazuhiko Nishi, Shigeru Saijo, Tomoko Kita, E. Nishi, T. Kimura, Keith Robertson, Jing Hu, R. A. Mcdonald, Keith G. Oldroyd, Stephanie Jessica Wan, Andrew H. Baker, Diane Jones, Krishnaraj S. Rathod, John Howard, Stuart J. Gallagher, A. K. Jain, Charles H. Knight, Sam Mohiddin, A. Mathur, Erin Smith, A. Wragg, Marije M. Vis, Marcel A.M. Beijk, Maik J. Grundeken, Janneke Baan, Klaus Koch, Joanna J. Wykrzykowska, J. G. P. Tijssen, Robbert J. de Winter, Jan J. Piek, José P.S. Henriques, T. Bauer, R Schiele, R. Zahn, S. Schneider, Bernhard Rauch, G. Sabin, Gunnar Steineck, J. Senges, Uwe Zeymer, Étienne Puymirat, E. Durand, K. Khalife, B. De Breyne, Vanda M. Lucke, Gillian H. Levy, Yves Cottin, J. Ferrrieres, Trevor W. Simon, Nicolas Danchin, Y. M. Lopatin, O. V. Ilyukhin, M. V. Ilyukhina, E. L. Kalganova, D. L. Tarasov, V. Ivanenko, Yves Devaux, Naser Ahmed Razvi, M. Vausort, Ged McCann, Dorothy H. Kelly, L. Zhang, Lavrova Ng, David R. Wagner, Iain Squire, Y. Ozaki, Aiko Tanaka, Kanji Ishibashi, T Tanimoto, Toshinao Yamano, Y. Ino, T. Yamaguchi, Takeshi Kubo, T. Imanishi, T Akasaka, Masahiko Takahata, Takeshi Kubo, T. Wada, Masahiro Orii, Toshinao Yamano, T Tanimoto, Y. Ino, T. Yamaguchi, T. Imanishi, T Akasaka, F. Imola, M. T. Mallus, V. Ramazzotti, M. Manzoli, Andrea A. Pappalardo, M. Occhipinti, L. Di Vito, Francesco Prati, Terue Okamura, Junichi Yamada, T. Nao, T. Suetomi, T Maeda, A. Hino, Takako Nakashima, Oda T, Tetsuji Miura, Masayo Matsuzaki, S Umemura, H. Kamihata, Shuji Nakamura, T. Sugiura, Tadashi Seno, K. Manabe, Saburo Tsujimoto, Miura Motohiro, T Iwasaka, Kenya Kusunose, A. Dahiya, M. Chadi Alraies, Diana Kwon, T. Marwick, Abbie Klein, T. Butz, L. Penfield Faber, Crystal Piper, G. Plehn, Dieter Horstkotte, H.-J. Trappe, R. M. Jimenez, J. M. Serrano, C Cristóbal, Pablo Talavera, P. Awanleh, Catherine Graupner, Antonio Curcio, J. J. Alonso Martin, A. Cresti, E. Capati, G. Guerrieri, Sauro Severi, C. Mornos, A. Ionac, D. Cozma, A. Mornos, S. Pescariu, S. Petrescu, S. Rekhraj, B. Szwejkowski, Adnan Nadir, S. Gandy, Jill George, Chim C. Lang, Allan D. Struthers, T. Yingchoncharoen, Sangita Agarwal, T. Marwick, Kiyohiro Takigiku, Masao Takeuchi, S. Nakatani, Chisato Izumi, S. Yuda, Kenji Sakata, N. Ohte, Kumiko Tanabe, Kohei Kaku, Masao Takeuchi, Kiyohiro Takigiku, S. Yasukouchi, Victor Mor‐Avi, Robin Lang, Y. Otsuji, S. A. Kleijn, Natesa G. Pandian, Leopoldo Pérez de Isla, O. Kamp, Michel Züber, P. Nyhoyannopoulos, Tim Forster, H. J. Nesser,
Oxford University Press
... Almenabar, sobre o drama do jovem marinheiro espanhol Ramon Sampedro. Alem de comover plateias no mundo inteiro, o ... pelo suicidio assistido seria desejavel como o fez Ramon Sampedro? Longe de assumir uma postura de juizes, mesmo ...
Tópico(s): Palliative Care and End-of-Life Issues
2009 - Conselho Federal de Medicina | Revista Bioética