
Bárbara Crisol, Camilla Bertuzzo Veiga, Luciene Lenhare, Renata Rosseto Braga, Vagner Ramon Rodrigues Silva, Adelino Sánchez Ramos da Silva, Dennys E. Cintra, Leandro Pereira de Moura, José Rodrigo Pauli, Eduardo R. Ropelle,
Nicotinamide Riboside (NR) is a NAD+ booster with wide physiological repercussion including the improvement on glucose and lipid homeostasis, increasing the life expectancy in mammals. However, the effects of NR on metabolism are only partially known. Here, we evaluated the effects of NR on the thermogenic response, highlighting the brown adipose tissue (BAT) in lean mice.Male C57BL/67 mice were supplement with NR (400 mg/Kg/day) during 5 weeks. The Comprehensive Lab Animal Monitoring System (CLAMS) ...
Tópico(s): Exercise and Physiological Responses
2018 - Elsevier BV | Life Sciences
Xosé Mahou, Bran Barral Buceta, Ángela Fernández Da Silva, Ramón Bouzas Lorenzo, Andrés Cernadas Ramos,
In the last decades, the use of Information and Communication Technologies (ICTs) has progressively spread to society and public administration. Health is one of the areas in which the use of ICTs has more intensively developed through what is now known as eHealth. That area has recently included mHealth. Spanish health system has stood out as one of the benchmarks of this technological revolution. The development of ICTs applied to health, especially since the outbreak of the pandemic caused by ...
Tópico(s): Health Literacy and Information Accessibility
2021 - Multidisciplinary Digital Publishing Institute | International Journal of Environmental Research and Public Health

Paulo Antônio Martins‐Júnior, Felipe Augusto da Silva Franco, Ramon Valério de Barcelos, Leandro Silva Marques, Maria Letícia Ramos‐Jorge,
Background There is little evidence regarding the risks and benefits of replantation of avulsed primary teeth. Aim The aim of this study was to perform a systematic review of the literature on the replantation of avulsed primary teeth, analysing the risks and benefits to help guide dentists regarding the best clinical decision‐making in such cases. Design The M edline/ P ubmed, LILACS , and S ci ELO databases were searched for articles published in E nglish, P ortuguese, G erman or S panish on the ...
Tópico(s): Dental Research and COVID-19
2013 - Wiley | International Journal of Paediatric Dentistry

Roberta Martins Costa Moreira Allgayer, Gustavo da Silva Borba, Ruy S. Moraes, Ramon Bossardi Ramos, Poli Mara Spritzer,
Objective The impact of gender-affirming hormone therapy (GAHT) on cardiovascular (CV) health is still not entirely established. A systematic review was conducted to summarize the evidence on the risk of subclinical atherosclerosis in transgender people receiving GAHT. Methods A systematic review was performed following Preferred Reporting Items for Systematic Reviews and Meta-analyses guidelines, and data were searched in PubMed, LILACS, EMBASE, and Scopus databases for cohort, case-control, and ...
Tópico(s): LGBTQ Health, Identity, and Policy
2023 - Elsevier BV | Endocrine Practice

Carlos K. Katashima, Thayana de Oliveira Micheletti, Renata Rosseto Braga, Rodrigo S. Gaspar, Ludger J.E. Goeminne, Alexandre Moura‐Assis, Bárbara Crisol, Rafael S. Brícola, Vagner Ramon Rodrigues Silva, Camila de Oliveira Ramos, Alisson L. da Rocha, Mariana Tavares, Fernando Moreira Simabuco, Valquíria Aparecida Matheus, Lucas I Buscaratti, Henrique Marques‐Souza, Patricia Pazos, David González-Touceda, Sulay Tovar, María del Carmen Garcia, José Cesar Rosa Neto, Rui Curi, Sandro Massao Hirabara, Patrı́cia C. Brum, Patrícia O. Prada, Leandro Pereira de Moura, José Rodrigo Pauli, Adelino Sánchez Ramos da Silva, Dennys E. Cintra, Lı́cio A. Velloso, Eduardo R. Ropelle,
Hypothalamic interleukin-6 (IL6) exerts a broad metabolic control. Here, we demonstrated that IL6 activates the ERK1/2 pathway in the ventromedial hypothalamus (VMH), stimulating AMPK/ACC signaling and fatty acid oxidation in mouse skeletal muscle. Bioinformatics analysis revealed that the hypothalamic IL6/ERK1/2 axis is closely associated with fatty acid oxidation– and mitochondrial-related genes in the skeletal muscle of isogenic BXD mouse strains and humans. We showed that the hypothalamic IL6/ ...
Tópico(s): Regulation of Appetite and Obesity
2022 - American Association for the Advancement of Science | Science Advances

André V. Cordeiro, Vagner Ramon Rodrigues Silva, José Rodrigo Pauli, Adelino Sánchez Ramos da Silva, Dennys E. Cintra, Leandro Pereira de Moura, Eduardo R. Ropelle,
Sphingolipids were discovered more than a century ago and were simply considered as a class of cell membrane lipids for a long time. However, after the discovery of several intracellular functions and their role in the control of many physiological and pathophysiological conditions, these molecules have gained much attention. For instance, the sphingosine-1-phosphate (S1P) is a circulating bioactive sphingolipid capable of triggering strong intracellular reactions through the family of S1P receptors ( ...
Tópico(s): Autophagy in Disease and Therapy
2018 - Wiley | Journal of Cellular Physiology

Ramon Ramos de Paula, Wallaf Costa Vimercati, Cintia da Silva Araújo, Leandro Levate Macedo, Luciano José Quintão Teixeira, Sérgio Henriques Saraiva,
The aim of this study was to evaluate the influence of temperature on drying kinetics and the physicochemical properties of whey powder. The whey foam was prepared and dried at 40, 50, 60, 70, and 80°C. The moisture ratio (MR) was calculated. Mathematical models were fitted to the MR data. The effective moisture diffusivity (Deff) and the activation energy were calculated. The samples were characterized in terms of moisture, water binding capacity (WBC), protein, and color. The optimal treatment was ...
Tópico(s): Microbial Inactivation Methods
2020 - Wiley | Journal of Food Processing and Preservation
Aurora Pinazo, Ramón Pons, Ana M. Marqués, Maribel Farfán, Anderson Ramos da Silva, Lourdes Pérez,
Their stability and low cost make catanionic vesicles suitable for application as drug delivery systems. In this work we prepared catanionic vesicles using biocompatible surfactants: two cationic arginine-based surfactants (the monocatenary
Tópico(s): Advanced Polymer Synthesis and Characterization
2020 - Multidisciplinary Digital Publishing Institute | Pharmaceutics

Lourdes Pérez, Ramón Pons, Francisco Fábio Oliveira de Sousa, M. Carmen Morán, Anderson Ramos da Silva, Aurora Pinazo,
Green surfactants are compounds derived from renewable sources of raw material that exhibit biodegradability and low toxicity. In this work the synthesis, solution, aggregation and biological properties of two families of green cationic arginine based surfactants have been investigated, Nα-acyl arginine methyl ester and arginine N-alkyl amide. Specifically we study: (i) the effect of self-aggregation on the cationic character, (ii) Liquid crystalline phases applying SAXS, (iii) surfactant ability to ...
Tópico(s): Surfactants and Colloidal Systems
2021 - Elsevier BV | Journal of Molecular Liquids

W.T. Clemente, Ana Rabello, Luciana Costa Faria, Vanessa Peruhype-Magalhães, Luciana I. Gomes, T. A. M. da Silva, Ramon Vieira Nunes, J.B. Iodith, Klaus Zanuncio Protil, Hosana Ramos Fernandes, J.R.G. Cortes, S.S.S. Lima, Agnaldo Soares Lima, Roberta Maia de Castro Romanelli,
Visceral leishmaniasis is an uncommon disease in transplant recipients; however, if left untreated, the mortality can be high. If an organ donor or recipient is known to be an asymptomatic Leishmania spp. carrier, monitoring is advised. This study proposes to assess the prevalence of asymptomatic Leishmania spp. infection in liver transplant donors and recipients from an endemic area. A total of 50 liver recipients and 17 liver donors were evaluated by direct parasite search, indirect fluorescent ...
Tópico(s): Parasites and Host Interactions
2013 - Elsevier BV | American Journal of Transplantation

Adriele Gomes da Silva, Larissa Oliveira Vilar, Viviane Oliveira Vilar, Fernando Pinto Coelho, Nayara Rithelly dos Santos Acioli, Ramon Brilhante Gonçalves Araújo Ramos, Jefferson Gomes Moreira, Thiago Rocha Diares, Danielly Ferreira da Silva, Mayra Santos da Cruz, Ricardo Gonzaga de Moura,
Sabendo da importância e das peculiaridades da caatinga traremos por meio desse artigo esclarecimentos e informações que conscientizem os pequenos e médios produtores do quanto a ação antrópica tem afetado negativamente o bioma, colocando inclusive algumas áreas da região em risco de desertificação. Para tanto, foi utilizado o método de pesquisa exploratória pois a atual situação enfrentada pelo país impossibilita uma pesquisa de campo, mas vale ressaltar que esse artigo não foi prejudicado por ...
Tópico(s): Rural Development and Agriculture
2021 - Arche Scientific and Editorial Consultancy | Revista Ibero-Americana de Humanidades, Ciências e Educação
J. Flores-Calderón, Segundo Morán, Guillermo Ramón-Garcı́a, Berenice González-Romano, María del Carmen Bojórquez-Ramos, Laura Cerdán-Silva, Pablo Hernández-Frías,
Identifying liver fibrosis is important to evaluate the severity of liver damage and to establish a prognosis. Utility of non-invasive markers of liver fibrosis has been proved in adults but there are few reports in children. The aim of this study was to evaluate Fibrotest® score and APRI suitability to identify children with liver fibrosis.68 children with chronic liver disease requiring liver biopsy were prospectively included from three 3rd-level pediatric hospitals. The same pathologist evaluated ...
Tópico(s): Liver Diseases and Immunity
2012 - Elsevier BV | Annals of Hepatology
Andrés Cernadas Ramos, Bran Barral Buceta, Ángela Fernández Da Silva, Ramón Bouzas Lorenzo,
Resumen Ofrecer un análisis pormenorizado de la evolución e implantación de las Tecnologías de la Información y la Comunicación (TIC) en el ámbito sanitario -eSalud- en España, atendiendo a los principales servicios implementados, su situación actual y sus perspectivas de futuro, así como a su posible impacto en el sistema sanitario y particularmente en sus usuarios. Se ha revisado la literatura científica sobre eSalud para identificar los servicios implementados más extendidos y sus características. ...
Tópico(s): Mobile Health and mHealth Applications
2020 - UNIVERSIDADE DE SÃO PAULO | Saúde e Sociedade

Bruno Brito Lemes, Lilian da Silva Miguêz, Rebeca Lopes Santos, João Carlos da Rocha Bastos Serafim, Juliana M. Figueiredo, Islam Farias Tavares, Madson de Godoi Pereira, Edson de Jesus Marquês, Florisvaldo da Silva Ramos, Ramon dos Santos El-Bachá, Alany Ingrid Ribeiro, Maria Fátima das Graças Fernandes da Silva, Lourdes Cardoso de Souza Neta,
Phytochemical investigation of the roots, leaves and stems of Deguelia costata resulted in the isolation of two new prenylated isoflavones, 5,5"-dihydroxy-4'-methoxy-6",6"-dimethyl-4",5"-dihydropyrano [2",3":7,8]isoflavone (1), and 5-hydroxy-4'-methoxy-5"-hydroxyisopropyl-4",5"-dihydrofurano[2",3":7,8]isoflavone (2), together with nine known compounds, 4'-O-methylderrone (3), 4'-O-methylalpinumisoflavone (4); 5-hydroxy-3',4'-dimethoxy-2",2"-dimethylpyrano[5",6":7,6]isoflavone (5), gancaonin M (6), robustin ( ...
Tópico(s): Biological Activity of Diterpenoids and Biflavonoids
2019 - Elsevier BV | Phytochemistry Letters

André V. Cordeiro, Rafael S. Brícola, Renata Rosseto Braga, Luciene Lenhare, Vagner Ramon Rodrigues Silva, Chadi P. Anaruma, Carlos K. Katashima, Bárbara Crisol, Fernando Moreira Simabuco, Adelino Sánchez Ramos da Silva, Dennys E. Cintra, Leandro Pereira de Moura, José Rodrigo Pauli, Eduardo R. Ropelle,
The impairment of the mitochondrial functions is a hallmark of aging. During aging, there is a downregulation of two mechanisms strictly associated with mitochondrial integrity, including the mitonuclear imbalance (eg, imbalance in mitochondrial- versus nuclear-encoded mitochondrial proteins) and the mitochondrial unfolded protein response (UPRmt). Here, we evaluated the effects of aerobic exercise in the mitonuclear imbalance and UPRmt markers in the skeletal muscle of old mice. We combined the physiological ...
Tópico(s): Autophagy in Disease and Therapy
2020 - Oxford University Press | The Journals of Gerontology Series A

Luciene Lenhare, Bárbara Crisol, Vagner Ramon Rodrigues Silva, Carlos K. Katashima, André V. Cordeiro, Karina Danielle Pereira, Augusto Ducati Luchessi, Adelino Sánchez Ramos da Silva, Dennys E. Cintra, Leandro Pereira de Moura, José Rodrigo Pauli, Eduardo R. Ropelle,
Sestrins and autophagy deficiencies are associated with several aging-related organic dysfunctions and metabolic disorders. Here we evaluate the effects of acute exercise on Sestrin 2 (Sesn2) protein content and autophagy markers in the skeletal muscle of experimental models of aging. Twenty-four months-old C57BL/6J male mice were submitted to a single bout of swimming exercise and the gastrocnemius muscle was evaluated by Western blot. Transcriptomic and phenotypic analysis were also performed by ...
Tópico(s): Lipid metabolism and biosynthesis
2017 - Elsevier BV | Experimental Gerontology
Ramón Silva-Vázquez, Emmanuel Flores‐Girón, Armando Quintero‐Ramos, Michael E. Hume, Gerardo Méndez‐Zamora,
The aim of this study was to investigate levels of inulin and pectin replacing pork back fat in meat batter (MB) formulation. Six treatments were evaluated: T1, control MB (100% pork back fat); T2, MB + 70% pork back fat (low fat); T3, MB + 85% pork back fat + 15% inulin; T4, MB + 70% pork back fat + 30% inulin; T5, MB + 85% pork back fat + 7.5% inulin + 7.5% pectin; and T6, MB + 70% pork back fat + 15% inulin + 15% pectin. T6 reduced pH, maintained brightness (L*), increased redness (a*), yellowness (b*), Chroma, and browning ...
Tópico(s): Food Quality and Safety Studies
2018 - Taylor & Francis | CyTA - Journal of Food

André V. Cordeiro, Guilherme Francisco Peruca, Renata Rosseto Braga, Rafael S. Brícola, Luciene Lenhare, Vagner Ramon Rodrigues Silva, Chadi Pellegrini Anaruma, Carlos K. Katashima, Bárbara Crisol, Lucas Torres Barbosa, Fernando Moreira Simabuco, Adelino Sánchez Ramos da Silva, Dennys E. Cintra, Leandro Pereira de Moura, José Rodrigo Pauli, Eduardo R. Ropelle,
The impairment of mitochondrial metabolism is a hallmark of aging. Mitonuclear imbalance and the mitochondrial unfolded protein response (UPRmt) are two conserved mitochondrial mechanisms that play critical roles in ensuring mitochondrial proteostasis and function. Here, we combined bioinformatics, physiological, and molecular analyses to examine the role of mitonuclear imbalance and UPRmt in the skeletal muscle of aged rodents and humans. The analysis of transcripts from the skeletal muscle of aged ...
Tópico(s): Endoplasmic Reticulum Stress and Disease
2020 - Springer International Publishing | GeroScience
Ramon Resende Leite, Renata Colombo, Fausto Eduardo Bimbi Júnior, Marcos R.V. Lanza, Hernane da Silva Barud, Conrado Ramos Moreira Afonso, Maria Inês Basso Bernardi,
Tópico(s): ZnO doping and properties
2024 - Elsevier BV | Chemical Engineering Journal

Ramón Silva, Ramon S. Rocha, Jonas T. Guimarães, Celso F. Balthazar, Hugo Scudino, Gustavo Luís de Paiva Anciens Ramos, Tatiana Colombo Pimentel, Márcia C. Silva, Paulo Henrique Fonseca da Silva, Maria Carmela K.H. Duarte, Mônica Q. Freitas, Adriano G. Cruz, Erick A. Esmerino,
This study aimed to evaluate the effects of the application of ohmic heating (OH) to milk (0, 2, 4, 6, 8, or 10 V cm−1, 72–75 °C/15 s) on the sensory profiling of dulce de leche (DL) evaluated using preferred attribute elicitation (PAE) and temporal Check-all-that-apply (TCATA) methodologies. In addition a consumer test was also performed. OH-DL samples presented increased scores for all the sensory attributes evaluated. Low or intermediate strength electric fields contributed to increase bitter taste ...
Tópico(s): Meat and Animal Product Quality
2020 - Elsevier BV | Food Research International

André Mário Mendes da Silva, A.R. Silva, Alexandre Moraes Pinheiro, Silva Ramos Freitas, V.D.A. Silva, Cleide Dos Santos Souza, James B. Hughes, Ramon dos Santos El-Bachá, M.F.D. Costa, Eudes S. Velozo, M. Tardy, Sílvia Lima Costa,
Prosopis juliflora is used for feeding cattle and humans. Intoxication with the plant has been reported, and is characterized by neuromuscular alterations and gliosis. Total alkaloidal extract (TAE) was obtained using acid/basic-modified extraction and was fractionated. TAE and seven alkaloidal fractions, at concentrations ranging 0.03–30 μg/ml, were tested for 24 h on astrocyte primary cultures derived from the cortex of newborn Wistar rats. The MTT test and the measure of LDH activity on the culture ...
Tópico(s): Curcumin's Biomedical Applications
2006 - Elsevier BV | Toxicon

Vanessa da Silveira Ramos, Odalys Cabrera, Eduardo Leal Oliveira Camargo, Alinne Batista Ambrósio, Ramon O Vidal, Desireé S. da Silva, Lays Cordeiro Guimarães, Sérgio Marangoni, José Roberto Postali Parra, Gonçalo Amarante Guimarães Pereira, Maria Lı́gia Rodrigues Macedo,
Native Inga laurina (Fabaceae) trypsin inhibitor (ILTI) was tested for anti-insect activity against Diatraea saccharalis and Heliothis virescens larvae. The addition of 0.1% ILTI to the diet of D. saccharalis did not alter larval survival but decreased larval weight by 51%. The H. virescens larvae that were fed a diet containing 0.5% ILTI showed an 84% decrease in weight. ILTI was not digested by the midgut proteinases of either species of larvae. The trypsin levels were reduced by 55.3% in the feces ...
Tópico(s): Insect Pest Control Strategies
2012 - Elsevier BV | Comparative Biochemistry and Physiology Part C Toxicology & Pharmacology

Vagner Ramon Rodrigues Silva, Carlos K. Katashima, Luciene Lenhare, Carla G. B. Silva, Joseane Morari, Rafael Ludemann Camargo, Lı́cio A. Velloso, Mário A. Saad, Adelino Sánchez Ramos da Silva, José Rodrigo Pauli, Eduardo R. Ropelle,
Obesity and aging are associated with hypothalamic inflammation, hyperphagia and abnormalities in the thermogenesis control.It has been demonstrated that the association between aging and obesity induces hypothalamic inflammation and metabolic disorders, at least in part, through the atypical hypothalamic transforming growth factor-β (TGF-β1).Physical exercise has been used to modulate several metabolic parameters.Thus, the aim of this study was to evaluate the impact of chronic exercise on TGF-β1 ...
Tópico(s): Adipokines, Inflammation, and Metabolic Diseases
2017 - Impact Journals LLC | Aging
Sandra Díez‐Villares, Miguel A. Ramos‐Docampo, Andrés da Silva‐Candal, Pablo Hervella, Abi Judit Vázquez-Ríos, Ana B. Dávila‐Ibáñez, Rafael López‐López, Ramón Iglesias‐Rey, Verónica Salgueiriño, María de la Fuente,
Abstract Magnetic resonance imaging (MRI) is one of the most powerful non‐invasive imaging modalities used in clinics due to its great spatial resolution and excellent soft‐tissue contrast, though still less sensitive than other techniques such as the nuclear imaging modalities. This lack of sensitivity can be improved with the use of contrast agents based on nanomaterials. In recent years, researchers have focused on the development of magnetic nanoparticles, given their role as enhancers of the ...
Tópico(s): Magnetic Properties and Synthesis of Ferrites
2021 - Wiley | Advanced Healthcare Materials

Eluã Ramos Coutinho, Robson Mariano da Silva, Jonni Guiller Ferreira Madeira, Pollyanna Rodrigues de Oliveira dos Santos Coutinho, Ronney Arismel Mancebo Boloy, Ángel Ramón Sanchez Delgado,
Abstract This study estimates and fills real flaws in a series of meteorological data belonging to four regions of the state of Rio de Janeiro. For this, an Artificial Neural Network (ANN) of Multilayer Perceptron (MLP) was applied. In order to evaluate its adequacy, the monthly variables of maximum air temperature and relative humidity of the period between 05/31/2002 and 12/31/2014 were estimated and compared with the results obtained by Multiple Linear Regression (MLR) and Regions Average (RA), and ...
Tópico(s): Solar Radiation and Photovoltaics
2018 - Sociedade Brasileira de Meteorologia | Revista Brasileira de Meteorologia
Andrés Cernadas Ramos, Ángela Fernández Da Silva, Bran Barral Buceta, Ramón Bouzas Lorenzo,
Background The accelerated development of information and communication technologies has made health care one of the pioneering fields in the incorporation of these tools. As new technologies have been applied, existing technologies have been sophisticated and improved and the concept of eHealth has expanded. However, these advances and expansion of eHealth do not seem to have served to adapt the supply of services to users’ demands; rather, supply seems to be governed by other variables. Objective ...
Tópico(s): Health Literacy and Information Accessibility
2023 - JMIR Publications | Journal of Medical Internet Research
Andrés Cernadas Ramos, Bran Barral Buceta, Ángela Fernández Da Silva, Ramón Bouzas Lorenzo, Ana Garaikoetxea Iturriria,
eHealth has grown significantly over the last decade. The aim of this study was to determine the level of use of information and communication technologies for health care in Spain and identify the main barriers to development. We used a qualitative study based on data obtained from 8 Spanish autonomous communities through semi-structured, in-depth interviews with key informants in eHealth management and planning. Programs present varying degrees of implementation. Services such as electronic prescriptions, ...
Tópico(s): Healthcare Systems and Technology
2020 - SAGE Publishing | International Journal of Health Services
Omar de Jesús Cabrera-Rosas, Ernesto Espíndola-Ramos, Salvador Alejandro Juárez-Reyes, Israel Julián-Macías, Paula Ortega-Vidals, Gilberto Silva-Ortigoza, Ramón Silva‐Ortigoza, Citlalli Teresa Sosa-Sánchez,
The aim of the present work is to give a geometrical characterization of Durnin's beams. That is, we compute the wavefronts and caustic associated with the nondiffracting solutions to the scalar wave equation introduced by Durnin. To this end, first we show that in an isotropic optical medium is an exact solution of the wave equation, if and only if, S is a solution of both the eikonal and Laplace equations, then from one and two-parameter families of this type of solution and the superposition ...
Tópico(s): Optical Polarization and Ellipsometry
2016 - IOP Publishing | Journal of Optics

Ludmila Salerno Leddomado, Ramón Silva, Jonas T. Guimarães, Celso F. Balthazar, Gustavo Luís de Paiva Anciens Ramos, Mônica Q. Freitas, Maria Carmela K.H. Duarte, Roberto P.C. Neto, Maria Inês Bruno Tavares, Tatiana Colombo Pimentel, Paulo Henrique Fonseca da Silva, Renata S.L. Raices, Márcia Cristina Silva, Adriano G. Cruz, Erick A. Esmerino,
Tópico(s): Sensory Analysis and Statistical Methods
2020 - Elsevier BV | Food Hydrocolloids
Gilberto Silva-Ortigoza, Israel Julián-Macías, Ernesto Espíndola-Ramos, Ramón Silva‐Ortigoza,
The aim of the present work is to show that any monochromatic solution to the scalar wave equation in free space defines a conservative Hamiltonian system, describing a particle of mass m = 1 / 2 and energy E = 1 , under the influence of the so-called quantum potential. We remark that the integral curves of its Poynting vector, exact optics energy trajectories, define a particular subset of solutions to the corresponding Hamilton equations. Furthermore, we introduce the zero quantum potential straight lines ...
Tópico(s): Quantum Information and Cryptography
2023 - Optica Publishing Group | Journal of the Optical Society of America B