Judy Allen, Kenneth McLeish, Marion Tran, Barbara Hall, Joan Bakewell, Mike Graham, Will Ellsworth-Jones, Alasdair Riley, Paul Nelson, Richard Ellis, Oliver Anderson, Tom Phillips, Jean Rafferty, Jon Swain, R B Green, Richard Faulks, John Peter, Mark Honigsbaum, Susan Hill, Mark Reason, Bemard Cafferty, Eric Dymock, Jill Hartley, Jeff Handall, Danby Bloch, John Diamond, Graham Rose, Dr Robert Cutler, Salmon spawning, Jana Ondrackova, Nicolette Jones, J R Hammond, Alistair Scott, Sally Payne, David Smith, Arthur Appleton, Frederic Raphael, Julian Joyce, Eric Dymock Motoring Correspondent, Mark Ellis, Mark Hosenball, Deborah Moggach, Graham Goodall, Richard Eaton, Patrick Stoddart, Susan Marling, Michael Jones Editor, Chris Ball Secretary, Iain Johnstone, Robert Sandall, Jeff Ranall Editor, Philippa Gregory, David Brierley, Keith Austin, Irwin Stelzer, John Newell, Dletmar Henker, Ivan Fallon, Deryk Brown, David Dougill, Noel Falconer, Geordie Greig Arts Correspondent, Joe Irving, Peter Reading, Cliff Temple, Jane Bird, Robert Gore-Langton, Hugh Pearman Architecture Correspondent, Helene Hanff, Maria Laura Avignolo, Egon Ronay, Hugh Canning, Margarette Driscoll, Jane Bird Technology Editor, Susan Crosland, H Alexander, David Cairns, Jola Smith, Norman Harris, Peter Kemp, Lord Queensberry, Julia Neuberger, Simon Townsley, Geoff Whitten, Anne Moffat, Robert Harris, Peter Millar, Richard Palmer Environment Correspondent, Gillian Ayres, George Perry, Carlotte Atkins, John Cassidy, Sue Mott, Robin Marlar, Mick Imlah, D Day, Robyn Beeche, Carolyn Bilska, Paul Donovan, Kenneth MacMillan, Amit Roy, Aileen Ballantyne, Caroline St John Brooks, David Hughes, Austin MacCurtain, David Leppard, John Piper, Pascal Rostain, Rufus Olins, Michael Durham, Nigel Bowden, Dr Alan Bullock, Dan Piraro, Martin Jacques, Michael Adler, Brian Walden, Sheila Hancock, Peter Wilsher, Gareth David, Christopher Falkus Director, Kate Saunders, S Kirkham, Kathy Acker, Nigel Thomas, James Wilson, Marie Colvin, Richard Cook, Lionel Karunasena, Lisa O'kelly, Craig Brown, Patrick Proctor, Stephen Jones, Stephen Thorpe, Desmond Shawe-Taylor, Brian Deer, Harry Mullan, Melvyn Bragg, Andrew Grice, Digby Anderson, Roger Warner, Martin Searby, Rob Ryan, Anthony Quinn, Patrick Rowley, Dilys Powell, Chris Jones, Andrew Hogg, Susie Bowen, Brough Scott, David Selbourne, Caroline McGhie, Richard Woods, Louise Branson, Bruno Mouron, Frances Rafferty, Joan Perrins, Marion Hume, Maurice Chittenden, Joy Melville, Peter Gill, Ian Dunning, Arthur Schafer, Earl Russell, Aileen Ballantyne Medical Correspondent, Brian MacArthur, Balraj Khanna, Toyah Willcox, Anne Fitzgerald, Geoffrey Hobbs, D J Taylor, Mihir Bose, Michael Smith, Philip Beresford, Godfrey Smith, Michael Austin, Ronald Reagan, Peter Morris, Andy Martin, Lionel Morrison, Jonathan Atkin, Brian Glanville, Antonia Fraser, Norman Macrae, Edward Pearce, Simon Jenkins, Godfrey Golzen, L A Chambers, J Sztuka, Jean Disspan, Andrew Lorenz, John Furbisher, Cynthia Harrod-Eagles, David Wickers, Colin Greenland, Joanne Gray, Clare Russell, Peter Godwin Diplomatic Correspondent, Marina Vaizey, Chris Lightbown, Richard Attenborough, Hugh Pearman, Andrew Lorenz Editor, Richard Caseby, Valerie Grove, Alix Kirsta, Paul Pickering, Frank Field, Tony James, David Smith Economics Editor, Neil MacLean, Tony Hetherington, Sue Nelson, Chris Blackhurst, Joanna Simon, Paul Gogarty, James Park, Iain Jenkins, Hilary Bristow, Boris Schapiro,
... help doctors as well as patients, writes Arthur Schafer Aids, the media and the medical establishment Michael ...
1989 - Gale Group | Sunday Times HA GDA
Khalifa Nsir, Gerhard Schäfer, Raphaël di Chiara Roupert, Olivier Razakarisoa, Renaud Toussaint,
et à la diffusion de documents scientifiques de niveau recherche, publiés ou non, émanant des établissements d'enseignement et de recherche français ou étrangers, des laboratoires publics ou privés.
Tópico(s): Geotechnical Engineering and Underground Structures
2011 - Elsevier BV | International Journal of Multiphase Flow
W. W. WILLESDEN, , M. COVARRUBIAS., A. C. HEARN., W. BRAMWELL BOOTH., ARTHUR W. PRESTON, F.R.Met.Soc., Hon., THOMAS WRIGHT., G. T. WRENCH, M.D., F. J. FOAKES-JACKSON, HENRY CHAPLIN., GEO. KEEBLE. Peterborough, Sept. 4., A TEACHER IN A PROVINCIAL MEDICAL SCHOOL., ANOTHER BANK MANAGER. September 5., D. W. SMITH. Glasgow, Aug. 31.,
... The Norfolk Floods. Details Of The Rainfall., Professor Schäfer On Life., To The Editor Of The Times., ...
1912 - Gale Group | TDA
Geoffrey Schwertz, Michelle S. Frei, Matthias Witschel, Matthias Rottmann, Ubolsree Leartsakulpanich, P. Chitnumsub, A. Jaruwat, Wanwipa Ittarat, Anja Schäfer, Raphael A. Aponte, Nils Trapp, Kerstin Mark, Pimchai Chaiyen, François Diederich,
Abstract Malaria remains a major threat to mankind due to the perpetual emergence of resistance against marketed drugs. Twenty‐one pyrazolopyran‐based inhibitors bearing terminal biphenyl, aryl sulfonamide, or aryl sulfone motifs were synthesized and tested towards serine hydroxymethyltransferase (SHMT), a key enzyme of the folate cycle. The best ligands inhibited Plasmodium falciparum ( Pf ) and Arabidopsis thaliana ( At ) SHMT in target, as well as Pf NF54 strains in cell‐based assays in the low nanomolar ...
Tópico(s): Hemoglobinopathies and Related Disorders
2017 - Wiley | Chemistry - A European Journal
Jonathan Northcroft, P B, Waldemar Januszczak, John Dugdale, Hala Jaber, J Norman, Dr David Lowry, David Brown, Helen Davies, Nicholas Rufford, Rob Hughes, John Peter, V S, Emma Moore, Amanda Ursell, Jonathan Miller, Ben Gelbum, George Garland, Adam Zamoyski, Adam Sweeting, J D, Emme Moore, Peter Wade, Roger McGough's, Frank Whitford, Kieran McCarthy, Nicola Venning, Kathryn Cooper, Alasdair Reld, Reland White, Tim Richards, Rory Godson, Gillian Hall, Frederic Raphael, Neil Wormald, E P, Andrew Sullivan, Clive Davis, Guy Dennis, John Lynch, Alice B-B, Richard Herring, Joseph Dunn, Tony Allen-Mills, Simon Wilde, Martin James, Barrie Parr, Tom Walker, Anthony Sattin, Robert Winnett, Tom Rigby, Irwin Stelzer, Sally kinners, Peter Wilson, Rosie Millard, Tom McEnaney, Luclnda Kemeny, David Dougill, John McKay, Neal Baldwin, John Gribbin, Philip Kingsley, John Waples Deputy Business Editor, Philip Kerr, Geraldine Hackett, Alan Frame, Marcus Tanner, David Hewson, Grace Ciappara, Barry Hugill, Cally Law, Jonathon Carr-Brown, Alasdair Reid, Hugh Canning, David Caims, Colin Mehigan, Jeremy Clarkson, Stewart Lee, Edward Porter, Victoria Segal, Joe Swift, Helen Kenny, Richard Events, Eben Black, Liz Edwards, George Perry, Adam Nathan, Nick Gardner, Paul Bailey, Graham Norton, Stefan Holter, Stuart Wavell, Christopher Silvester, George Miller, Alastair Hendy, Vincent Crump, Maria Grachvogel, Joan Lingard, Hugh McIlvanney, Chris Woodhead, Jonathan Todd, Dennis Ruston, Lucinda Kemeny, Peter Small, Jasper Gerard, Paul Driver, Ken Martin, Michael Woodhead, John Humphrys, Charlie Catchpole, Nicholas Hellen, Richard Brooks, John Follain, Johan Cruyff, Ian Hawkey, Simon Fanshawe, Cosmo landesman, Christopher Morgan, David Leppard, John Douce, Katie Hickman, Tony Fearon, Terence Jones, Brenda Maddox, Laurie Graham, Amber Cowan, Mark Edwards, Tilly Bagshawe, Susan Clark, Eben Black Chief Political Correspondent, Danny O'Brien, Stave Grant, Victoria O'Brien, Nigel Freeman, Vicki Clifford, Raymond Keene, Ed Vaizey, Gareth Huw Davies, Cosmo Landesman, Marie Colvin, Diana Wright, David Orr, Debble Atkinson, Stephen Jones, Dominic O'Connell, Alexis Giles, Louise Armitstead, Uzi Mahnaimi, Nick Cain, Peta Bee, Judith Prescott, Natalie Graham, Steven Rose, M J, Kate Rew, Nigel Blagg, Colin McDOWELL, Gordon Musson, David Walsh, Jonas Bernstein, Nicolas Batfour, Stephen Armstrong, John Elliott, Dan Claims, Victoria O'brien, Helen Chrislett, Quentin Peck, Roland White, Garth Alexander, Tom Hunter, Simon Braund, Rory Godson Business Editor, Monica Littleboy, Maurice Chittenden, Bill Gorman, Richard Brooks Arts Editor, Richard Rae, Mark Franchetti, L Cox-Freeman, Ray Hutton, Martin Ivens, James Hughes, Dennis Yates, Louise Armistead, Frank Fitzgibbon, Michael Fitzpatrick, Mr Arafat, Saily Kinnes, Leah Hardy, John Harlow, Mrs Eleanor Coker, Godfrey Smith, Robert Winnett Consumer Affairs Correspondent, Jack Haigh, Bethan Ryder, Barry Collins, Gillian Wilmot, J Blackwell, John Waples, A A Gill, Ros Dodd, Heather Mills, Matthew Campbell, Brian Glanville, John Carey, Robert Barrie, Tom Robbins, Alex Leach, Ray O'Brien, James Hardwick, Jools Holland, Jonathan Carr-Brown, Will Iredale, Mathew Cambell, Maria McErlane, Hazel Curry, Ann McFerran, Jason Corcoran, R H, Naomi Caine, David Wickers, Simon Spilsbury, Hugh Thomson, Michael Clower, Minette Marrin, Alan Scaife, Mark Hodson, Graham Norwood, David Powell, Joe Lovejoy, Jonathan Futrell, Shelley Von Strunckel, Rupert Steiner, Philip Bobbitt, David Budworth, Hugh Pearman, Michael Kerr, Peter Horner, Dea Birkett, David Harbord, Tom Deveson, Julie Brooke, Penny Perrick, Lee Carter, Simon Crerar, Mrs Mills, Martin Ray Philbert, Sarah Baxter, Brian Schofield, Martin Booth, James Wright, Joanna Simon, Chris Feetenby, India Knight, Steve Grant, Simon Bevan, Sandy Gall, Meera Mahida, Dan Pearson, Dominic Rushe, Boris Schapiro,
... he owes it all to a boyhood coach Schafer aiming to win battle of German coaches The ...
2002 - Gale Group | Sunday Times HA GDA
Geoffrey Schwertz, Matthias Witschel, Matthias Rottmann, Roger V. Bonnert, Ubolsree Leartsakulpanich, P. Chitnumsub, A. Jaruwat, Wanwipa Ittarat, Anja Schäfer, Raphael A. Aponte, Susan A. Charman, Karen L. White, Abhijit Kundu, Surajit Sadhukhan, Mel Lloyd, Gail M. Freiberg, Myron Srikumaran, Marc Siggel, Adrian Zwyssig, Pimchai Chaiyen, François Diederich,
Target-based approaches toward new antimalarial treatments are highly valuable to prevent resistance development. We report several series of pyrazolopyran-based inhibitors targeting the enzyme serine hydroxymethyltransferase (SHMT), designed to improve microsomal metabolic stability and to identify suitable candidates for in vivo efficacy evaluation. The best ligands inhibited Plasmodium falciparum (Pf) and Arabidopsis thaliana (At) SHMT in target assays and PfNF54 strains in cell-based assays with ...
Tópico(s): Enzyme Structure and Function
2017 - American Chemical Society | Journal of Medicinal Chemistry
Design by Miss Bessie Ascough., DUNRAVEN., J. C. STAMP., RICHARD A. ROBINSON. "Rossett, " Wanstead, Jan. 5., J. D. REES., YOUR CORRESPONDENT IN THE TRANSVAAL AT THE TIME. Junior Carlton Club, Jan. 5., ANTHONY A. BOWLBY. EDWARD J. DOMVILLE. W. ARBUTHNOT LANE. STEPHEN PAGET. E. SHARPEY-SCHAFER., Carlton Club, Jan. 5. DENNIS HERBERT., ALEX. FINDLATER, M.D., J.P., Middlesex., H. FITZ HERBERT WRIGHT., J. LANE-CLAYPON., THE INCOME-TAX ADJUSTMENT AGENCY, LTD., , J. HONNER, Commr., R.N. (Retd.)., AN OFFICER., W. P. KOE, Commander, R.N. (Retired). January 4.,
... French Historian., City Attempted Arson Charge., Fortunate St. Raphael. A Place Of Rapid Growth. Gounod And Alphonse ...
1921 - Gale Group | TDA
Geoffrey Schwertz, Matthias Witschel, Matthias Rottmann, Ubolsree Leartsakulpanich, P. Chitnumsub, A. Jaruwat, Watcharee Amornwatcharapong, Wanwipa Ittarat, Anja Schäfer, Raphael A. Aponte, Nils Trapp, Pimchai Chaiyen, François Diederich,
Abstract With the discovery that serine hydroxymethyltransferase (SHMT) is a druggable target for antimalarials, the aim of this study was to design novel inhibitors of this key enzyme in the folate biosynthesis cycle. Herein, 19 novel spirocyclic ligands based on either 2‐indolinone or dihydroindene scaffolds and featuring a pyrazolopyran core are reported. Strong target affinities for Plasmodium falciparum ( Pf ) SHMT (14–76 n m ) and cellular potencies in the low nanomolar range (165–334 n m ) were measured ...
Tópico(s): Pneumocystis jirovecii pneumonia detection and treatment
2018 - Wiley | ChemMedChem
Patrick Sieber, Anny Schäfer, Raphael Lieberherr, François Le Goff, Manuel Stritt, Richard W.D. Welford, John Gatfield, O Péter, Oliver Nayler, Urs Lüthi,
Pathological features of pulmonary fibrosis include accumulation of myofibroblasts and increased extracellular matrix (ECM) deposition in lung tissue. Contractile α-smooth muscle actin (α-SMA)-expressing myofibroblasts that produce and secrete ECM are key effector cells of the disease and therefore represent a viable target for potential novel anti-fibrotic treatments. We used primary normal human lung fibroblasts (NHLF) in two novel high-throughput screening assays to discover molecules that inhibit ...
Tópico(s): Inhalation and Respiratory Drug Delivery
2018 - Public Library of Science | PLoS ONE
Sabine Förster, Uriel Koziol, Tina Schäfer, Raphaël Duvoisin, Katia Cailliau, Mathieu Vanderstraete, Colette Dissous, Klaus Brehm,
Background Alveolar echinococcosis (AE) is a lethal zoonosis caused by the metacestode larva of the tapeworm Echinococcus multilocularis. The infection is characterized by tumour-like growth of the metacestode within the host liver, leading to extensive fibrosis and organ-failure. The molecular mechanisms of parasite organ tropism towards the liver and influences of liver cytokines and hormones on parasite development are little studied to date. Methodology/Principal findings We show that the E. ...
Tópico(s): Parasite Biology and Host Interactions
2019 - Public Library of Science | PLoS neglected tropical diseases
Melissa Amrein, Xinmin S. Li, Joan Walter, Zeneng Wang, Tobias Zimmermann, Ivo Strebel, Ursina Honegger, Kathrin Leu, Ibrahim Schäfer, Raphael Twerenbold, Christian Puelacher, Noemi Glarner, Thomas Nestelberger, Luca Koechlin, Benjamin Ceresa, Philip Haaf, Adam Bakula, Michael J. Zellweger, Stanley L. Hazen, Christian Mueller,
Trimethylamine N-oxide (TMAO) has been associated with cardiovascular outcomes. However, the diagnostic value of TMAO and its precursors have not been assessed for functionally relevant coronary artery disease (fCAD) and its prognostic potential in this setting needs to be evaluated.Among 1726 patients with suspected fCAD serum TMAO, and its precursors betaine, choline and carnitine, were quantified using liquid chromatography tandem mass spectrometry. Diagnosis of fCAD was performed by myocardial ...
Tópico(s): Tryptophan and brain disorders
2022 - Springer Science+Business Media | Clinical Research in Cardiology
Patrick Sieber, Anny Schäfer, Raphael Lieberherr, Silvia L. Caimi, Urs Lüthi, Jesper Ryge, Jan H. Bergmann, François Le Goff, Manuel Stritt, Peter Blattmann, Bérengère Renault, Patrick Rammelt, Bruno Sempere, Diego Freti, R. O. Studer, Eric S. White, Magdalena Birker, Maxime Boucher, Oliver Nayler,
In the progression phase of idiopathic pulmonary fibrosis (IPF), the normal alveolar structure of the lung is lost and replaced by remodeled fibrotic tissue and by bronchiolized cystic airspaces. Although these are characteristic features of IPF, knowledge of specific interactions between these pathological processes is limited. Here, the interaction of lung epithelial and lung mesenchymal cells was investigated in a coculture model of human primary airway epithelial cells (EC) and lung fibroblasts ( ...
Tópico(s): Medical Imaging and Pathology Studies
2022 - American Society for Clinical Investigation | JCI Insight
Gerhard Schäfer, Raphaël di Chiara Roupert, Amir H. Alizadeh, Mohammad Piri,
The predictions of two recent and two classical mathematical models are compared with experimentally measured three-phase relative permeabilities. Experimentally determined constitutive relationships in two-phase systems were used as model input parameters to numerically predict relative permeabilities (kr) in three-phase systems. Then the estimated results were compared with experimental three-phase permeabilities measured along decreasing water saturation/decreasing oil saturation/increasing gas ...
Tópico(s): Power Transformer Diagnostics and Insulation
2020 - Elsevier BV | Advances in Water Resources
Raphael Schäfer, Till Nicke, Henning Höfener, Annkristin Lange, Dorit Merhof, Friedrich Feuerhake, Volkmar Schulz, Johannes Lotz, Fabian Kießling,
Abstract Foundational models, pretrained on a large scale, have demonstrated substantial success across non-medical domains. However, training these models typically requires large, comprehensive datasets, which contrasts with the smaller and more specialized datasets common in biomedical imaging. Here we propose a multi-task learning strategy that decouples the number of training tasks from memory requirements. We trained a universal biomedical pretrained model (UMedPT) on a multi-task database ...
Tópico(s): AI in cancer detection
2024 - Nature Portfolio | Nature Computational Science
Alex Steimle, Lena Michaelis, Flaviana Di Lorenzo, Thorsten Kliem, Tobias Münzner, Jan Kevin Maerz, Andrea Schäfer, Anna Lange, Raphael Parusel, Kerstin Gronbach, Kerstin Fuchs, Alba Silipo, Hasan Halit Öz, Bernd J. Pichler, Ingo B. Autenrieth, Antonio Molinaro, Julia-Stefanie Frick,
Generated by gram-negative bacteria, lipopolysaccharides (LPSs) are one of the most abundant and potent immunomodulatory substances present in the intestinal lumen. Interaction of agonistic LPS with the host myeloid-differentiation-2/Toll-like receptor 4 (MD-2/TLR4) receptor complex results in nuclear factor κB (NF-κB) activation, followed by the robust induction of pro-inflammatory immune responses. Here we have isolated LPS from a common gut commensal, Bacteroides vulgatus mpk (BVMPK), which provides ...
Tópico(s): Digestive system and related health
2019 - Elsevier BV | Molecular Therapy
Rathana Kim, Hugo Bergugnat, Lise Larcher, Matthieu Duchmann, Marie Passet, Stéphanie Gachet, Wendy Cuccuini, Mårina Lafage‐Pochitaloff, Cédric Pastoret, Nathalie Grardel, Vahid Asnafi, Beat W. Schäfer, Éric Delabesse, Raphaël Itzykson, Lionel Adès, Yosr Hicheri, Yves Chalandon, Carlos Graux, Patrice Chevallier, Mathilde Hunault, Thibaut Leguay, Françoise Huguet, Véronique Lhéritier, Hervé Dombret, Jean Soulier, Philippe Rousselot, Nicolas Boissel, Emmanuelle Clappier,
Abstract Low hypodiploidy defines a rare subtype of B-cell acute lymphoblastic leukemia (B-ALL) with a dismal outcome. To investigate the genomic basis of low-hypodiploid ALL (LH-ALL) in adults, we analyzed copy-number aberrations, loss of heterozygosity, mutations, and cytogenetics data in a prospective cohort of Philadelphia (Ph)-negative B-ALL patients (n = 591, ages 18–84 years), allowing us to identify 80 LH-ALL cases (14%). Genomic analysis was critical for evidencing low hypodiploidy in many cases ...
Tópico(s): Chronic Myeloid Leukemia Treatments
2023 - American Association for Cancer Research | Blood Cancer Discovery
D. Schäfer, Raphaël Rosso, Renato Fricker, Gulio Spagnoli, Gernot Jundt, Hans Gerber, Michael Heberer,
Tópico(s): Transplantation: Methods and Outcomes
2000 - Springer Science+Business Media | Archives of Orthopaedic and Trauma Surgery
Khalifa Nsir, Gerhard Schäfer, Raphaël di Chiara Roupert, Lionel Mercury,
A numerical simulator based on the discrete network model approach has been developed to simulate drainage processes in a water-saturated porous medium. To verify the predictive potential of the approach to simulate the unstable migration of a dense nonaqueous phase liquid (DNAPL) at the pore scale, the numerical model was applied to laboratory experiments conducted on a sand-filled column. The parameters relative to pore body size and pore throat size used in the construction of the equivalent network ...
Tópico(s): Hydraulic Fracturing and Reservoir Analysis
2018 - Elsevier BV | Journal of Contaminant Hydrology
Harry C. Blair, Jonathan Soboloff, Lisa Robinson, Irina L. Tourkova, Quitterie C. Larrouture, Michelle R. Witt, Ida Holásková, Rosana Schafer, Meenal Elliott, Raphael Hirsch, John B. Barnett,
Objective We have shown in vitro and in vivo that osteoclast maturation requires calcium-release activated calcium (CRAC) channels. In inflammatory arthritis, osteoclasts mediate severe and debilitating bone erosion. In the current study, we assess the value of CRAC channels as a therapeutic target to suppress bone erosion in acute inflammatory arthritis. Methods Collagen-induced arthritis (CIA) was induced in mice. The CRAC channel inhibitor 3,4-dichloropropionaniline (DCPA) and a placebo was administered ...
Tópico(s): Cardiac electrophysiology and arrhythmias
2016 - BMJ | RMD Open
Alexandra Wittmann, Peter A. Bron, Iris I. van Swam, Michiel Kleerebezem, Patrick Adam, Kerstin Gronbach, Sarah Menz, Isabell Flade, Annika Bender, Andrea Schäfer, Ali Giray Korkmaz, Raphael Parusel, Ingo B. Autenrieth, Julia-Stefanie Frick,
Toll-like receptor (TLR) expression in patients with inflammatory bowel disease is increased when compared with healthy controls. However, the impact of TLR signaling during inflammatory bowel disease is not fully understood.In this study, we used a murine model of acute phase inflammation in bone marrow chimeric mice to investigate in which cell type TLR2/4 signal induction is important in preventing intestinal inflammation and how intestinal dendritic cells are influenced. Mice were either fed ...
Tópico(s): Inflammatory Bowel Disease
2015 - Oxford University Press | Inflammatory Bowel Diseases
Raphael Knaier, Juliane Schäfer, Anja Rossmeissl, Christopher Klenk, Henner Hanssen, Christoph Höchsmann, Christian Cajochen, Arno Schmidt‐Trucksäss,
Many sports competitions take place during television prime time, a time of the day when many athletes have already exceeded their time of peak performance. We assessed the effect of different light exposure modalities on physical performance and melatonin levels in athletes during prime time. Seventy-two young, male elite athletes with a median (interquartile range) age of 23 (21; 29) years and maximum oxygen uptake (VO2max) of 63 (58; 66) ml/kg/min were randomly assigned to three different light exposure ...
Tópico(s): Behavioral Health and Interventions
2017 - Frontiers Media | Frontiers in Physiology
Lisa Voigtländer, Raphael Twerenbold, Ulrich Schäfer, Lenard Conradi, Ümniye Balaban, Raffi Bekeredjian, Stephan Ensminger, Thomas Walther, Andreas Beckmann, Christian Frerker, Timm Bauer, Christian W. Hamm, Helge Möllmann, Sabine Bleiziffer,
•In contrast to frailty, underweight is a simple parameter and body weight is assessed routinely during every hospital stay. •Underweight is associated with increased short- and long-term mortality after TAVI and SAVR. •Underweight patients treated by SAVR had increased rates of postprocedural complications, whereas TAVI proved to be safe also in underweight patients. •The impact on mortality was even stronger in patients with severe underweight (BMI <18.5 kg/m2). According to the Valve Academic Resortium, ...
Tópico(s): Infective Endocarditis Diagnosis and Management
2020 - Elsevier BV | The American Journal of Cardiology
Abstract Yield Determination in Laboratory. A Method for Quantitative Flour Evaluation in Wheat Starch Industries . Because of fast rising world‐market prices for wheat the problem of the yield determination of starch from wheat flour should be taken into special consideration. Earlier methods have not been changed in principle but the results can be found much faster than before. The modified method gives the chance to watch the extractability of flour as well as the findings with regard to the quality ...
Tópico(s): Wheat and Barley Genetics and Pathology
1975 - Wiley | Starch - Stärke
Anna Lange, Andrea Schäfer, Annika Bender, Alex Steimle, Sina Beier, Raphael Parusel, Julia-Stefanie Frick,
Insects and mammals share evolutionary conserved innate immune responses to maintain intestinal homeostasis. We investigated whether the larvae of the greater wax moth Galleria mellonella may be used as an experimental organism to distinguish between symbiotic Bacteroides vulgatus and pathobiotic Escherichia coli, which are mammalian intestinal commensals. Oral application of the symbiont or pathobiont to G. mellonella resulted in clearly distinguishable innate immune responses that could be verified ...
Tópico(s): Insect Utilization and Effects
2018 - Frontiers Media | Frontiers in Immunology
Laurent M. Willems, Yunus Balcik, Anna H. Noda, Kai Siebenbrodt, Sina Leimeister, Jeannie McCoy, Ricardo Kienitz, Makoto Kiyose, Raphael Reinecke, Jan-Hendrik Schäfer, Johann Philipp Zöllner, Sebastian Bauer, Felix Rosenow, Adam Strzelczyk,
When the SARS-CoV-2 pandemic reached Europe in 2020, a German governmental order forced clinics to immediately suspend elective care, causing a problem for patients with chronic illnesses such as epilepsy. Here, we report the experience of one clinic that converted its outpatient care from personal appointments to telemedicine services.Documentations of telephone contacts and telemedicine consultations at the Epilepsy Center Frankfurt Rhine-Main were recorded in detail between March and May 2020 ...
Tópico(s): Epilepsy research and treatment
2020 - Elsevier BV | Epilepsy & Behavior
Jean‐Philippe Collet, Claude Lesty, Gilles Montalescot, John W. Weisel,
... London1988: 110-179Google Scholar, 12Crespo J. Serra J. Schafer R.W. Signal Process. 1995; 47: 201-225Crossref Scopus (123) Google Scholar, 14Lesty C. Raphael M. Nonnenmacher L. Leblond-Missenard V. Delcourt A. ...
Tópico(s): Diabetic Foot Ulcer Assessment and Management
2003 - Elsevier BV | Journal of Biological Chemistry
Alex Steimle, Sarah Menz, Annika Bender, Brianna Ball, Alexander N.R. Weber, Thomas Hagemann, Anna Lange, Jan Kevin Maerz, Raphael Parusel, Lena Michaelis, Andrea Schäfer, Hans Yao, Hanna-Christine Löw, Sina Beier, Mehari Tesfazgi Mebrhatu, Kerstin Gronbach, Samuel Wagner, David Voehringer, Martin Schaller, Birgit Fehrenbacher, Ingo B. Autenrieth, Tobias A. Oelschlaeger, Julia-Stefanie Frick,
Escherichia coli represents a classical intestinal gram-negative commensal. Despite this commensalism, different E. coli strains can mediate disparate immunogenic properties in a given host. Symbiotic E. coli strains such as E. coli Nissle 1917 (EcN) are attributed beneficial properties, e.g., promotion of intestinal homeostasis. Therefore, we aimed to identify molecular features derived from symbiotic bacteria that might help to develop innovative therapeutic alternatives for the treatment of intestinal ...
Tópico(s): Clostridium difficile and Clostridium perfringens research
2019 - Public Library of Science | PLoS Biology
Jan Kevin Maerz, Constanze Trostel, Anna Lange, Raphael Parusel, Lena Michaelis, Andrea Schäfer, Hans Yao, Hanna-Christine Löw, Julia-Stefanie Frick,
B cells fulfill multifaceted functions that influence immune responses in health and disease. In autoimmune diseases such as inflammatory bowel disease, multiple sclerosis and rheumatoid arthritis, depletion of functional B cells results in an aggravation of disease in humans and respective mouse models. This could be due to a lack of a pivotal B cell subpopulation: regulatory B cells (Bregs). Although Bregs represent only a small proportion of all immune cells, they exhibit critical properties in ...
Tópico(s): Gut microbiota and health
2020 - Frontiers Media | Frontiers in Immunology
Anja Klußmeier, Carolin Massalski, Kathrin Putke, Gesine Schäfer, Jürgen Sauter, Daniel Schefzyk, Jens Pruschke, Jan A. Hofmann, Daniel Fürst, Raphaël Carapito, Seiamak Bahram, Alexander H. Schmidt, Vinzenz Lange,
MICA and MICB are ligands of the NKG2D receptor and thereby influence NK and T cell activity. MICA/B gene polymorphisms, expression levels and the amount of soluble MICA/B in the serum have been linked to autoimmune diseases, infections and cancer. In hematopoietic stem cell transplantation, MICA matching between donor and patient has been correlated with reduced acute and chronic graft-versus-host disease and improved survival. Hence, we developed an extremely cost-efficient high-throughput workflow ...
Tópico(s): CAR-T cell therapy research
2020 - Frontiers Media | Frontiers in Immunology
Michal Segal‐Rozenhaimer, Yael Dubowski, C. Jahn, Klaus Schäfer, Georg Gerl, Raphael Linker,
In recent years open-path FTIR systems (active and passive) have demonstrated great potential and success for monitoring air pollution, industrial stack emissions, and trace gas constituents in the atmosphere. However, most of the studies were focused mainly on monitoring gaseous species and very few studies have investigated the feasibility of detecting bio-aerosols and dust by passive open-path FTIR measurements. The goal of the present study was to test the feasibility of detecting a cloud of ...
Tópico(s): Air Quality Monitoring and Forecasting
2010 - SPIE | Proceedings of SPIE, the International Society for Optical Engineering/Proceedings of SPIE