Isabel Pavão Martins, Carolina Maruta, Pedro Alves, Clara Loureiro, J. Morgado, Joana Tavares, Raquel Gil‐Gouveia,
The effect of headache on cognitive performance is controversial, due to conflicting results obtained from studies in clinical or population settings. We aimed to understand if migraine and other headaches modify the rates of decline on different cognitive measures, during a 5-year interval.A cohort of community dwelling adults (> 50 years) with migraine (MH), non-migraine headaches (NMH) and controls without headache (WoH), was assessed by a comprehensive neuropsychological battery with tests of memory, ...
Tópico(s): Functional Brain Connectivity Studies
2020 - Springer Nature | The Journal of Headache and Pain
Produção Nacional
Revisado por pares
Eduardo Aliprandini, Joana Tavares, Raquel Hoffmann Panatieri, Sabine Thiberge, Márcio Yamamoto, Olivier Silvie, Tomoko Ishino, Masao Yuda, Sylvie Dartevelle, François Traincard, Silvia Beatriz Boscardin, Rogério Amino,
The circumsporozoite protein (CSP) is the major surface protein of malaria sporozoites (SPZs), the motile and invasive parasite stage inoculated in the host skin by infected mosquitoes. Antibodies against the central CSP repeats of different plasmodial species are known to block SPZ infectivity1–5, but the precise mechanism by which these effectors operate is not completely understood. Here, using a rodent Plasmodium yoelii malaria model, we show that sterile protection mediated by anti-P. yoelii ...
Tópico(s): Research on Leishmaniasis Studies
2018 - Nature Portfolio | Nature Microbiology
Lúcia Tavares, Raquel Barbosa,
Geriatric depression is a common and debilitating psychopathology, but evidence supports the efficacy of psychotherapy in its treatment. Group therapy provides advantages over individual interventions. However, only three systematic reviews have focused specifically on the efficacy of group therapy for geriatric depression. To ascertain the effects of group psychotherapy on geriatric depression in people aged 60 years and older, compared with alternative treatments or no treatment. A systematic ...
Tópico(s): Family Caregiving in Mental Illness
2018 - Elsevier BV | Archives of Gerontology and Geriatrics
Ewa Piskadlo, Alexandra Tavares, Raquel A. Oliveira,
Mitotic chromosome assembly remains a big mystery in biology. Condensin complexes are pivotal for chromosome architecture yet how they shape mitotic chromatin remains unknown. Using acute inactivation approaches and live-cell imaging in Drosophila embryos, we dissect the role of condensin I in the maintenance of mitotic chromosome structure with unprecedented temporal resolution. Removal of condensin I from pre-established chromosomes results in rapid disassembly of centromeric regions while most ...
Tópico(s): DNA and Nucleic Acid Chemistry
2017 - eLife Sciences Publications Ltd | eLife
Bárbara Tavares, Raquel Jacinto, Pedro Sampaio, Sara Pestana, Andreia Pinto, Andreia Vaz, Mónica Roxo‐Rosa, Rui Gardner, Telma Lopes, Britta Schilling, Ian Henry, Leonor Saúde, Susana S. Lopes,
Foxj1a is necessary and sufficient to specify motile cilia. Using transcriptional studies and slow-scan two-photon live imaging capable of identifying the number of motile and immotile cilia, we now established that the final number of motile cilia depends on Notch signalling (NS). We found that despite all left-right organizer (LRO) cells express foxj1a and the ciliary axonemes of these cells have dynein arms, some cilia remain immotile. We identified that this decision is taken early in development ...
Tópico(s): Renal and related cancers
2017 - eLife Sciences Publications Ltd | eLife
Produção Nacional
Revisado por pares
Kátia M. Lima, Juliana P. Vago, Thaís Rolla de Caux, Graziele L. Negreiros-Lima, Michelle A. Sugimoto, Luciana P. Tavares, Raquel Gregório Arribada, Aline A. F. Carmo, Izabela Galvão, Bruno Rocha Cordeiro Costa, Frederico Marianetti Soriani, Vanessa Pinho, Egle Solito, Mauro Perretti, Mauro Martins Teixeira, Lirlândia P. Sousa,
Tópico(s): Protease and Inhibitor Mechanisms
2017 - Elsevier BV | Journal of Biological Chemistry
António M. Santos, M. Pilar Cabezas, Ana I. Tavares, Raquel Xavier, Madalena Branco,
Abstract Motivation: TCS is a widely used haplotype network reconstruction software, but lacks the capability of overlapping genetic with geographic structure, which is often a first step in phylogeographic analysis. Results: tcsBU is a web-based program that extends the capabilities of TCS, by implementing haplotype classification into an arbitrary user-defined scheme, which is displayed as pie-chart like graphs embedded into the network. Taking advantage of modern graphic libraries, tcsBU also ...
Tópico(s): Genomics and Phylogenetic Studies
2015 - Oxford University Press | Bioinformatics
Marta Oliveira, Filipa S. Reis, Diana Sousa, Catarina Tavares, Raquel T. Lima, Isabel C.F.R. Ferreira, Tiago dos Santos, M. Helena Vasconcelos,
Ganoderma lucidum is one of the most extensively studied mushrooms as a functional food and as a chemopreventive agent due to its recognized medicinal properties. Some G. lucidum extracts have shown promising antitumor potential. In this study, the bioactive properties of various extracts of G. lucidum, from both the fruiting body and the spores, were investigated. The most potent extract identified was the methanolic fruiting body extract, which inhibited the growth of a gastric cancer cell line ( ...
Tópico(s): Polysaccharides and Plant Cell Walls
2014 - Royal Society of Chemistry | Food & Function
R. TAVARES, Raquel Souza, A.O. CORREIA,
Currently, the new information and communication technologies are providing different forms of expression for the world population, particularly for young people. However, we need to make technology an ally in favor of humanity, using mainly as a process of teaching and learning in schools. In this context, ICT acts as a resource in the insertion of a new teaching method, arousing student interest in the matters raised, often in the classroom. Thus, ICTs can help to a better understanding of some ...
Tópico(s): Education and Digital Technologies
2014 - Associação Acadêmica de Propriedade Intelectual | Revista Gestão Inovação e Tecnologias
Produção Nacional
Revisado por pares
Luís Marcelo Tavares, Raquel D.C. Kallemback,
Tópico(s): Metal Extraction and Bioleaching
2012 - Elsevier BV | Minerals Engineering
Lurdes Santos, Cândida Abreu, S. Xerinda, Margarida Tavares, Raquel Lucas, António Sarmento,
In view of the close relationship of Portugal with African countries, particularly former Portuguese colonies, the diagnosis of malaria is not a rare thing. When a traveller returns ill from endemic areas, malaria should be the number one suspect. World Health Organization treatment guidelines recommend that adults with severe malaria should be admitted to an intensive care unit (ICU). Severe cases of malaria in patients admitted to an ICU were reviewed retrospectively (1990-2011) and identification ...
Tópico(s): Parasites and Host Interactions
2012 - BioMed Central | Malaria Journal
Débora A. Tavares, Raquel Sá‐Leão, Maria Miragaia, Hermı́nia de Lencastre,
Abstract Background The incidence of pediatric infections due to community-associated methicillin-resistant Staphylococcus aureus (CA-MRSA), including children with no identifiable risk factors, has increased worldwide in the last decade. This suggests that healthy children may constitute a reservoir of MRSA in the community. In this study, nested within a larger one on nasopharyngeal ecology, we aimed to: (i) evaluate the prevalence of MRSA colonizing young children in Portugal; and (ii) compare results ...
Tópico(s): Bacterial Identification and Susceptibility Testing
2010 - BioMed Central | BMC Infectious Diseases
Tatiana P. Resende, Mónica Ferreira, Marie‐Aimée Teillet, Ana Teresa Tavares, Raquel P. Andrade, Isabel Palmeirim,
Vertebrate embryo somite formation is temporally controlled by the cyclic expression of somitogenesis clock genes in the presomitic mesoderm (PSM). The somitogenesis clock is believed to be an intrinsic property of this tissue, operating independently of embryonic midline structures and the signaling molecules produced therein, namely Sonic hedgehog (Shh). This work revisits the notochord signaling contribution to temporal control of PSM segmentation by assessing the rate and number of somites formed ...
Tópico(s): Epigenetics and DNA Methylation
2010 - National Academy of Sciences | Proceedings of the National Academy of Sciences
Ana P. M. Tavares, Raquel O. Cristóvão, José A. F. Gamelas, José M. Loureiro, Rui A.R. Boaventura, Eugénia A. Macedo,
Abstract BACKGROUND: The use of enzymes has attracted much interest for the decolourization of dyes from wastewater as an alternative to conventional treatments, which have limitations. Laccase can be used to decolourize dyes and its substrate range can be extended by inclusion of mediators. RESULTS: Sequential decolourization of reactive dyes was carried out by a laccase mediator system using as mediators violuric acid and 1‐hydroxybenzotriazole. Violuric acid resulted in a high level of decolourization ...
Tópico(s): Microbial Metabolism and Applications
2008 - Wiley | Journal of Chemical Technology & Biotechnology
Ana P. M. Tavares, Raquel O. Cristóvão, José M. Loureiro, Rui A.R. Boaventura, Eugénia A. Macedo,
Abstract BACKGROUND: In the textile industry, large quantities of intensely coloured and toxic effluents are released, causing serious environmental pollution. Several biotechnological approaches have been suggested to eliminate this pollution source in an eco‐efficient manner. Laccase can be used to decolourise dyes and its substrate range can be extended by inclusion of a mediator. RESULTS: A screening using several laccase mediators (2,2‐azinobis(3‐ethylbenzothiazoline‐6‐sulfonate) (ABTS), 1‐hydroxybenzotriazole ( ...
Tópico(s): Dyeing and Modifying Textile Fibers
2008 - Wiley | Journal of Chemical Technology & Biotechnology
Ana P. M. Tavares, Raquel O. Cristóvão, José M. Loureiro, Rui A.R. Boaventura, Eugénia A. Macedo,
Three-level Box–Behnken factorial design with three factors (pH, temperature and enzyme concentration) combined with response surface methodology (RSM) was applied to optimize the dye degradation of reactive red 239 (RR239), reactive yellow 15 (RY15) and reactive blue 114 (RB114) dyes by commercial laccase. Mathematical models were developed for each dye showing the effect of each factor and their interactions on colour removal. The model predicted for RY15 that a decolourization above 90% (after 24 h) ...
Tópico(s): Microbial Metabolism and Applications
2008 - Elsevier BV | Journal of Hazardous Materials
Produção Nacional
Revisado por pares
José Albertino Bendassolli, Everaldo Máximo, Glauco Arnold Tavares, Raquel de Fátima Ignoto,
THE CENA/USP.A system for disposal and recovery of the main effluents and chemical waist from isotope separation plants and enriched compounds-15 N and 34 S production has been carried out at the Stable Isotope Laboratory (LIE) of the CENA/USP.Around four hundred thousand liters of effluents has been recovered yearly.Among the recovered chemical wastes, the more relevant are: ammonia; brome; ammonium and sodium sulfate; sodium hydroxide; sulfur dioxide; and hydrochloric acid.Chemical wastes containg ...
Tópico(s): Chemical Synthesis and Characterization
2003 - Brazilian Chemical Society | Química Nova
Produção Nacional
Revisado por pares
José Albertino Bendassolli, Glauco Arnold Tavares, Raquel de Fátima Ignoto, Alexssandra Luiza Rodrigues Molina Rosseti,
RECOVERING PROCEDURES FOR LIQUID AND SOLID Ag RESIDUES.A simple procedure for recovering Ag, generated as residual solutions, from three different analytical methods, is presented.Based on the rate of the total Ag mass recovered, to the initial one in the initial residual solutions, efficiency as high as 97,9 ± 2,9% was obtained in the process.The purity of Ag, as Ag 2 O, was verified by employing this reagent in the determination of S in plant tissue.This leads to the generation of a solid metallic ...
Tópico(s): Wastewater Treatment and Reuse
2003 - Brazilian Chemical Society | Química Nova
Produção Nacional
Revisado por pares
Têmis Maria Félix, Bibiana Mello de Oliveira, Milena Artifon, Isabelle Carvalho, Filipe Andrade Bernardi, Ida Vanessa Döederlein Schwartz, Jonas Alex Morales Saute, Victor Evangelista de Faria Ferraz, Angelina Xavier Acosta, Ney Boa‐Sorte, Domingos Alves, Tatiana Amorim, Gisele Maria Araujo Felix Adjuto, Rosemarie Elizabeth Schimidt Almeida, Flávia Resedá Brandão, Larissa Souza Mario Bueno, Maria Denise Fernandes Carvalho de Andrade, Cristina Cagliari, Maria Terezinha Cardoso, Ellaine Dóris Fernandes Carvalho, Marcela Câmara Machado Costa, Antonette S. El-Husny, Lavínia Schüler‐Faccini, Rodrigo Ambrósio Fock, Rodrigo Florêncio, Marcial Francis Galera, Roberto Giugliani, Liane de Rosso Giuliani, A. S. Grumach, Dafne Dain Gandelman Horovitz, Juan Clinton Llerena-Junior, Chong A. E. Kim, Rayana Elias Maia, Ana Maria Martins, Paula Frassinetti Vasconcelos de Medeiros, Nina Rosa de Castro Musolino, Marcelo Eidi Nita, Henrique Gil da Silva Nunesmaia, Jose Carlison Santos de Oliveira, Wagner José Martins Paiva, Helena Pimentel, Louise Lapagesse de Camargo Pinto, Vânia Mesquita Gadelha Prazeres, Betânia de Freitas Rodrigues Ribeiro, Erlane Marques Ribeiro, Márcia Rodrigues Jardim, Maria José Sparça Salles, Maria Teresa Vieira Sanseverino, Eliane Pereira dos Santos, Mara Lúcia Schmitz Ferreira Santos, Flávia Mori Sarti, Luiz Carlos Santana da Silva, Raquel Tavares Boy da Silva, Carlos Eduardo Steiner, Ana Beatriz Winter Tavares, Thais Bonfim Teixeira, A Vergara, Paulo Ricardo Gazzola Zen, Marcos Guimarães Zuchetti,
Abstract The Brazilian Policy of Comprehensive Care for People with Rare Diseases (BPCCPRD) was established by the Ministry of Health to reduce morbidity and mortality and improve the quality of life of people with rare diseases (RD). Several laboratory tests, most using molecular genetic technologies, have been incorporated by the Brazilian Public Health System, and 18 specialised centres have so far been established at university hospitals (UH) in the capitals of the Southern, Southeastern and Northeastern ...
Tópico(s): Genomic variations and chromosomal abnormalities
2022 - BioMed Central | Orphanet Journal of Rare Diseases
Hélène Badouin, Amandine Velt, François Gindraud, Timothée Flutre, Vincent Dumas, Sonia Vautrin, William Marande, Jonathan Corbi, Erika Sallet, Jérémy Ganofsky, Sylvain Santoni, Dominique Guyot, Eugenia Ricciardelli, Kristen Jepsen, Jos Käfer, Hélène Bergès, Éric Duchêne, Franck Picard, Philippe Hugueney, Raquel Tavares, Roberto Baciliéri, Camille Rustenholz, Gabriel Marais,
A key step in domestication of the grapevine was the transition from separate sexes (dioecy) in wild Vitis vinifera ssp. sylvestris (V. sylvestris) to hermaphroditism in cultivated Vitis vinifera ssp. sativa (V. vinifera). It is known that V. sylvestris has an XY system and V. vinifera a modified Y haplotype (Yh) and that the sex locus is small, but it has not previously been precisely characterized.We generate a high-quality de novo reference genome for V. sylvestris, onto which we map whole-genome ...
Tópico(s): Plant and animal studies
2020 - BioMed Central | Genome biology
Aline Muyle, Hélène Martin, Niklaus Zemp, Maéva Mollion, Sophie Gallina, Raquel Tavares, Alexandre Sérgio Silva, Thomas Bataillon, Alex Widmer, Sylvain Glémin, Pascal Touzet, Gabriel Marais,
About 15,000 angiosperm species (∼6%) have separate sexes, a phenomenon known as dioecy. Why dioecious taxa are so rare is still an open question. Early work reported lower species richness in dioecious compared with nondioecious sister clades, raising the hypothesis that dioecy may be an evolutionary dead-end. This hypothesis has been recently challenged by macroevolutionary analyses that detected no or even positive effect of dioecy on diversification. However, the possible genetic consequences ...
Tópico(s): Ecology and Vegetation Dynamics Studies
2020 - Oxford University Press | Molecular Biology and Evolution
Produção Nacional
Revisado por pares
Evelyn Quintanilha Vianna, Rafael Mina Piergiorge, Andressa Pereira Gonçalves, Jussara Mendonça dos Santos, Veluma Calassara, Carla Rosenberg, Ana Cristina Victorino Krepischi, Raquel Tavares Boy da Silva, Suely Rodrigues dos Santos, Márcia Gonçalves Ribeiro, Filipe Brum Machado, Enrique Medina‐Acosta, Márcia Mattos Gonçalves Pimentel, Cíntia Barros Santos-Rebouças,
Tópico(s): CRISPR and Genetic Engineering
2020 - Springer Science+Business Media | Molecular Neurobiology
Raquel Tavares, Ana Ramos, Abel Rouboa,
Gasification is an innovative and effective process which reduces the amount of waste produced by society and affords a synthetic gas with diverse applicability. In this plasma gasification study at high temperatures, a previously developed Aspen Plus model was used for municipal solid waste (MSW). The study is focused on the behavior of the equivalence ratio (ER), steam to MSW (S/MSW) ratio and gasification temperature (T), as a function of three gasification agents (air, O2 and steam), assessing the ...
Tópico(s): Recycling and utilization of industrial and municipal waste in materials production
2019 - Elsevier BV | Waste Management
Produção Nacional
Revisado por pares
Teresa Raquel Tavares Serejo, Amandda Évelin Silva-Carvalho, Luma Dayane de Carvalho Filiú-Braga, Francisco de Assis Rocha Neves, Rinaldo Wellerson Pereira, Juliana Lott Carvalho, Felipe Saldanha‐Araújo,
There is an active search for the ideal strategy to potentialize the effects of Mesenchymal Stem-Cells (MSCs) over the immune system. Also, part of the scientific community is seeking to elucidate the therapeutic potential of MSCs secretome and its extracellular vesicles (EVs), in order to avoid the complexity of a cellular therapy. Here, we investigate the effects of human adipose MSCs (AMSCs) licensing with INF-γ and TLR3 agonist over AMSCs proliferation, migration, as well as the immunomodulatory ...
Tópico(s): Immune cells in cancer
2019 - Multidisciplinary Digital Publishing Institute | Cells
Raquel Tavares, Eliseu Monteiro, Fouzi Tabet, Abel Rouboa,
This study is dedicated to present a reliable numerical methodology using Aspen Plus process simulator capable of performing a sensibility analysis of the downdraft gasification of Portuguese forest residues. Effects of critical parameters, including gasification temperature and steam-to-biomass ratio (SBR) on composition of the produced gas are discussed. The sensibility analysis is conducted using Aspen Plus simulator incorporating Fortran subroutines. The model is validated by experimental data ...
Tópico(s): Fire dynamics and safety research
2019 - Elsevier BV | Renewable Energy
Produção Nacional
Revisado por pares
Dominique Sternadt, Amandda Évelin Silva-Carvalho, Mariella Guimarães Lacerda, Teresa Raquel Tavares Serejo, Octávio Luiz Franco, Rinaldo Wellerson Pereira, Juliana Lott Carvalho, Francisco de Assis Rocha Neves, Felipe Saldanha‐Araújo,
LL-37 is a host-defense peptide (HDP) and exerts a broad spectrum of microbicidal activity against bacteria, fungi, and viral pathogens. This peptide also interacts with human cells and influences their behavior, promoting angiogenesis, wound healing, immunomodulation, and affecting apoptosis. Lately, significant advances have been achieved regarding the elucidation of underlying mechanisms related to LL-37 effects over neutrophil and monocytes. However, how T-cells respond to LL-37 stimulation is ...
Tópico(s): Immunotherapy and Immune Responses
2018 - Elsevier BV | Biomedicine & Pharmacotherapy
Aline Muyle, Niklaus Zemp, Cécile Fruchard, Radim Čegan, Jan Vrána, Clothilde Deschamps, Raquel Tavares, Roman Hobza, Franck Picard, Alex Widmer, Gabriel Marais,
Sex chromosomes have repeatedly evolved from a pair of autosomes. Consequently, X and Y chromosomes initially have similar gene content, but ongoing Y degeneration leads to reduced expression and eventual loss of Y genes1. The resulting imbalance in gene expression between Y genes and the rest of the genome is expected to reduce male fitness, especially when protein networks have components from both autosomes and sex chromosomes. A diverse set of dosage compensating mechanisms that alleviates these ...
Tópico(s): CRISPR and Genetic Engineering
2018 - Nature Portfolio | Nature Plants
Raquel Tavares, Ana Ramos, Abel Rouboa,
In this paper, a previously developed Aspen Plus model for gasification of biomass was adapted to the gasification of microplastics in a temperature range of 400–1200 °C. The effect of parameters such as equivalence ratio (ER), steam-to-biomass ratio (SBR) and gasification temperature in hydrogen production was evaluated, as well as three different gasifying agents namely air, O2 and steam were tested. The relationship between all these variables was assessed in order to better characterize the final ...
Tópico(s): Polymer crystallization and properties
2018 - Elsevier BV | Energy Conversion and Management
Raquel Tavares, Sushil Kumar Pathak,
Macrophages play an important role in the generation of host immune responses against H. pylori. In this study, we investigated the effect of a functionally uncharacterized H. pylori secreted protein HP1173 on macrophage responses. In a screen of eight H. pylori strains, similar expression levels of the HP1173 protein were observed in the whole-cell extracts, however; the amount of protein released into the culture medium varied significantly among strains. Recombinant purified HP1173 (rHP1173) was ...
Tópico(s): Veterinary medicine and infectious diseases
2018 - Elsevier BV | Microbial Pathogenesis
Produção Nacional
Revisado por pares
Neusa Jessen, Albertino Damasceno, Carla Silva‐Matos, Edite Tuzine, Tavares Madede, Raquel Mahoque, Patrícia Padrão, Francisco Mbofana, Jorge Polónia, Nuno Lunet,
To assess the current prevalence, awareness, treatment and control of arterial hypertension in Mozambican population, including adolescents and young adults, and to appraise their trends over the past decade, for the 25-64 years old population.A cross-sectional study of a representative sample of the population aged 15-64 years (n = 2965) was conducted in 2014-2015, following the Stepwise Approach to Chronic Disease Risk Factor Surveillance. Data from a survey conducted in 2005 using the same methodological ...
Tópico(s): Global Public Health Policies and Epidemiology
2017 - Lippincott Williams & Wilkins | Journal of Hypertension