Directory of Open Access Journals (DOAJ)
George Wald, James M. Krainin,
Currently, no pharmacological therapies treat skeletal muscle insulin resistance in pathological conditions such as type 2 diabetes, age-associated diseases, and cancer. Therefore, there is an unmet need to identify the molecular mechanisms ...The molecular events governing skeletal muscle glucose uptake have pharmacological potential for managing insulin resistance in conditions such as obesity, diabetes, and cancer. With no current pharmacological treatments to target skeletal muscle insulin ...
Tópico(s): Antioxidant Activity and Oxidative Stress
1963 - National Academy of Sciences | Proceedings of the National Academy of Sciences
Retinoic acid (RA) is one of the principal active metabolites of vitamin A (retinol) which mediates a spectrum of critical physiological and developmental processes. Transcriptional regulation by RA is mediated primarily by members of the retinoic acid receptor (RAR) subfamily of the nuclear receptor (NR) superfamily of transcription factors. NRs bind specific genomic DNA sequence motifs and engage coregulators and components of the basal transcription machinery to effect transcriptional regulation ...
Tópico(s): Antioxidant Activity and Oxidative Stress
2012 - SAGE Publishing | Nuclear Receptor Signaling
... adipocyte primary cultures: role of nuclear thyroid hormone receptor expression Get access C Guerra, C Guerra 1Departamento de Bioquímica y Biología Molecular II, Centro Mixto Consejo Superior ...
Tópico(s): Cancer, Hypoxia, and Metabolism
1994 - Oxford University Press | Endocrinology
Javier Carlos Rodríguez Álvarez, Hugh Smeltekop, Cuba Nicanor, Laura Mendoza, Manuel Gregorio Loza-Murguia,
... de sólidos y de la demanda química y bioquímica de oxigeno. De los nueve parámetros evaluados, seis cumplen con los valores máximos permisibles para la descarga en fuente receptor (arroyo) y tres de ellas están fuera del ...
Tópico(s): Water Resource Management and Quality
2011 - Selva Andina Research Society | Journal of the Selva Andina Research Society
FEBS LettersVolume 128, Issue 1 p. 111-113 Full-length articleFree Access Photo-affinity inactivation of gonadotropin releasing hormone receptors E. Hazum, E. Hazum Department of Hormone Research, The Weizmann Institute of Science, Rehovot, PO Box 26, 76100, IsraelSearch for more papers by this author E. Hazum, E. Hazum Department of Hormone Research, The Weizmann Institute of Science, Rehovot, PO Box 26, 76100, IsraelSearch for more papers by this author First published: June 01, 1981 https://doi. ...
Tópico(s): Antioxidant Activity and Oxidative Stress
1981 - Wiley | FEBS Letters
Modulation of the ligand-binding activity and protein kinase activity of homogeneous phorboid and ingenoid receptor from the brain by various fatty acyl-CoAs, fatty acid esters, fatty acids, and detergents was studied. Long-chain fatty acyl-CoAs (C10-C20), like certain acidic phospholipids, activated the ligand-receptor interaction. The extent of activation increased with the increasing chain length of fatty acyl-CoA. Short-chain fatty acyl-CoAs (C0-C6), fatty acids, and fatty acid esters were essentially ...
Tópico(s): Antioxidant Activity and Oxidative Stress
1985 - Elsevier BV | Archives of Biochemistry and Biophysics
The objective of this review is to provide an overview of intermittent fasting regimens, summarize the evidence on the health benefits of intermittent fasting, and discuss physiological mechanisms by which intermittent fasting might lead to improved ...Read More
Tópico(s): Estrogen and related hormone effects
1992 - Annual Reviews | Annual Review of Nutrition
Retinoids are metabolites of retinol (vitamin A), which act as signalling molecules in embryogenesis and as stimulators of cellular differentiation. The potency of retinoids as differentiating agents has led to their successful use in treating skin diseases and some forms of cancer. The retinoid X receptors (RXRs) are receptors for the vitamin A metabolite 9-cis retinoic acid, and they are members of the steroid/thyroid hormone receptor superfamily of DNA binding nuclear hormone receptors. The RXRs ...
Tópico(s): Antioxidant Activity and Oxidative Stress
1997 - Elsevier BV | The International Journal of Biochemistry & Cell Biology
ABSTRACT: The mitogen‐activated protein kinase (MAPK) pathway, classically associated with cell growth and dependent on tyrosine kinases such as MAPK kinase (MEK), can modulate smooth muscle contractility, and our laboratory has tested the hypothesis that 5‐HT can activate the MAPK pathway in arterial smooth muscle through activation of a 5‐HT 2A receptor. Tyrosine kinase inhibitors including genistein and the specific MEK inhibitor PD098059, but not the inactive tyrosine kinase congener daidzein ...
Tópico(s): Phytochemicals and Antioxidant Activities
1998 - Wiley | Annals of the New York Academy of Sciences
Manuel Mark, Norbert B. Ghyselinck, Pierre Chambon,
Retinoids, the active metabolites of vitamin A, regulate complex gene networks involved in vertebrate morphogenesis, growth, cellular differentiation and homeostasis. Studies performed in vitro, using either acellular systems or transfected cells, have shown that retinoid actions are mediated through heterodimers between the RAR and RXR nuclear receptors. However, in vitro studies indicate what is possible, but not necessarily what is actually occurring in vivo, because they are performed under ...
Tópico(s): Antioxidant Activity and Oxidative Stress
2009 - SAGE Publishing | Nuclear Receptor Signaling
J. Rubio‐Briones, Iborra Juan, J.L. Monrós Lliso, Juán Casanova Ramón-Borja, R. Dumont Martínez, J.V. Ricós Torrent, Eduardo Solsona Narbón, Eduardo Orduña Aznar, José A. Martínez-Climent, José Antonio López‐Guerrero,
... VSG, PCR, hemograma y recuento diferencial leucocitario (RDL), bioquímica estándar, ß2-microglobulina, CEA, CA 12.5, CA 50, CA 15.3, ferritina, interleukina-6, receptor de la interleukina-2, factor de necrosis tumoral ...
Tópico(s): Pancreatic and Hepatic Oncology Research
2004 - Elsevier BV | Actas Urológicas Españolas
We previously isolated THP-1 subtype cells (sTHP-1), a cell line that expresses scanty amounts of scavenger receptor A (ScR-A) and does not undergo foam cell formation when incubated with acetylated low-density lipoprotein (Ac-LDL). In this study, we investigated the accumulation of esterified cholesterol in sTHP-1 cells incubated with oxidized LDL (Ox-LDL), a physiologically modified lipoprotein in human. While sTHP-1 cells incubated with Ac-LDL accumulated only small amounts of esterified cholesterol, ...
Tópico(s): Cholesterol and Lipid Metabolism
2001 - Elsevier BV | Atherosclerosis
Tópico(s): Antioxidant Activity and Oxidative Stress
1980 - Nature Portfolio | Nature
Ligand-induced structural alterations of retinoid X receptor (RXR) appear to facilitate receptor homodimerization, to enhance DNA binding of RXR homodimeric complexes, and to dictate the transcriptional activation properties of RXR complexes bound to response elements located in the promoter region of 9-cis-retinoic acid responsive genes. The technique of limited proteolysis was used to address 9-cis-retinoic acid-induced RXR conformational change and to identify receptor region(s) which undergo ...
Tópico(s): Antioxidant Activity and Oxidative Stress
1994 - Elsevier BV | Journal of Biological Chemistry
specific proteins in the nucleus act as transcription factors upon activation through binding of small molecules (all-trans-retinoic acid, thyroid hormone, vitamin D, and others). The activated (liganded) receptors bind to specific DNA elements as heterodimers, each in combination with the retinoic acid-X receptor (RXR). 9-Cis-retinoic acid binds to RXR with high affinity and activates it. Though 9-cis-retinoic acid was initially found in animal tissues, in later work 9-cis-retinoic acid could not ...
Tópico(s): Antioxidant Activity and Oxidative Stress
2006 - Oxford University Press | Nutrition Reviews
Vitamin A, retinol, circulates in blood bound to retinol binding protein (RBP). In some tissues, the retinol-RBP complex (holo-RBP) is recognized by a membrane receptor, termed STRA6, which mediates uptake of retinol into cells. Recent studies have revealed that, in addition to serving as a retinol transporter, STRA6 is a ligand-activated cell surface signaling receptor that, upon binding of holo-RBP activates JAK/STAT signaling, culminating in the induction of STAT target genes. It has further been ...
Tópico(s): Estrogen and related hormone effects
2016 - Springer Nature | Sub-cellular biochemistry/Subcellular biochemistry
The last few years have witnessed a rapid increase in our knowledge of the retinoid-related orphan receptors RORα, -β, and -γ (NR1F1-3), their mechanism of action, physiological functions, and their potential role in several pathologies. The characterization of ROR-deficient mice and gene expression profiling in particular have provided great insights into the critical functions of RORs in the regulation of a variety of physiological processes. These studies revealed that RORa plays a critical role ...
Tópico(s): Antioxidant Activity and Oxidative Stress
2009 - SAGE Publishing | Nuclear Receptor Signaling
Iphigenia Tzameli, Steven S. Chua, Boris J. Cheskis, David D. Moore,
BACKGROUND: CAR/RXR heterodimers bind a variety of hormone response elements and activate transcription in the absence of added ligands. This constitutive activity of murine CAR can be inhibited by the inverse agonist ligand androstanol or increased by the agonist TCPOBOP. RXR agonists activate some RXR heterodimer complexes, which are termed permissive, while other non-permissive complexes are not responsive to such ligands. RESULTS: Direct protein-protein interaction studies demonstrate that the ...
Tópico(s): Antioxidant Activity and Oxidative Stress
2003 - BioMed Central | Nuclear Receptor
ADVERTISEMENT RETURN TO ISSUEPREVArticleNEXTThe Conformation of 20-Oxopregnane Hormone from Molecular Orbital Calculations and a Consideration of the Cortisol ReceptorLemont KierCite this: J. Med. Chem. 1968, 11, 5, 915–919Publication Date (Print):September 1, 1968Publication History Published online20 September 2004Published inissue 1 September 1968https://doi.org/10.1021/jm00311a603RIGHTS & PERMISSIONSArticle Views44Altmetric-Citations28LEARN ABOUT THESE METRICSArticle Views are the COUNTER-compliant ...
Tópico(s): Estrogen and related hormone effects
1968 - American Chemical Society | Journal of Medicinal Chemistry
Steven G. Britt, Vincent W. S. Chiu, Gerard T. Redpath, Scott R. VandenBerg,
Ascorbic acid is commonly used as an antioxidant to prevent the decomposition of ligands in neurotransmitter receptor studies, but may alter biological membranes by initiating lipid peroxidation in the presence of physiologic metal ions. The aim of the present study was to characterize the effect of ascorbic acid-induced lipid peroxidation on an applicable membrane receptor and to examine an appropriate antioxidant system. Ascorbic acid generated significant lipid peroxidation (5.5 to 45 fold increase ...
Tópico(s): Pesticide Exposure and Toxicity
1992 - Informa | Journal of Receptor Research
Donald N. Cook, Hong Soon Kang, Anton M. Jetten,
In this overview, we provide an update on recent progress made in understanding the mechanisms of action, physiological functions, and roles in disease of retinoic acid related orphan receptors (RORs). We are particularly focusing on their roles in the regulation of adaptive and innate immunity, brain function, retinal development, cancer, glucose and lipid metabolism, circadian rhythm, metabolic and inflammatory diseases and neuropsychiatric disorders. We also summarize the current status of ROR ...
Tópico(s): Antioxidant Activity and Oxidative Stress
2015 - AgiAl Publishing House | Nuclear Receptor Research
In the past few decades, cDNAs for endothelial scavenger receptors that bind to negatively charged molecules, particularly acetylated low density lipoproteins (Ac-LDL), have been cloned by expression cloning using modified LDL as ligands. A prototypic members of endothelial scavenger receptor family, namely, scavenger receptor class B type I (SR-BI) has been characterized as a high density lipoprotein (HDL) receptor. Another prototypic member, CD36, has been determined as a multiple ligand receptor ...
Tópico(s): Neutrophil, Myeloperoxidase and Oxidative Mechanisms
2006 - Elsevier BV | Progress in Lipid Research
Depression and stress-related disorders are leading causes of death worldwide. Standard treatments elevating serotonin or noradrenaline levels are not sufficiently effective and cause adverse side effects. A connection between dopamine pathways and stress-related disorders has been suggested. Compounds derived from herbal medicine could be a promising alternative. We examined the neuroprotective effects of ursolic acid (UA) by focusing on dopamine signalling. Trolox equivalent capacity assay was ...
Tópico(s): Medicinal Plants and Bioactive Compounds
2020 - Elsevier BV | Phytomedicine
Vincent Giguère, Ronald M. Evans,
The landmark 1987 discovery of the retinoic acid receptor (RAR) came as a surprise, uncovering a genomic kinship between the fields of vitamin A biology and steroid receptors. This stunning breakthrough triggered a cascade of studies to deconstruct the roles played by the RAR and its natural and synthetic ligands in embryonic development, skin, growth, physiology, vision, and disease as well as providing a template to elucidate the molecular mechanisms by which nuclear receptors regulate gene expression. ...
Tópico(s): Estrogen and related hormone effects
2022 - Bioscientifica | Journal of Molecular Endocrinology
Tópico(s): Antioxidant Activity and Oxidative Stress
1969 - Nature Portfolio | Nature
Cellular retinoic acid-binding protein (CRABP) appears in vertebrate organisms in two isoforms, CRABPI and II, with distinct distribution and functions. CRABPII, when combined with its retinoic acid (RA) ligand, interacts specifically with the liganded RA receptor complex (RAR.RXR), which is bound to the RA response elements of particular genes in order to greatly activate their expression. Thus, liganded CRABPII acts as a coactivator for RAR.RXR.
Tópico(s): Antioxidant Activity and Oxidative Stress
2009 - Oxford University Press | Nutrition Reviews
Supplemental vitamin E (α-tocopherol) is taken daily by more than 35 million people in the US. Following absorption and liver uptake, the fate of vitamin E is largely unknown. Of potential importance are recent clinical studies that have reported adverse effects of vitamin E that may be directly related to its hepatic metabolism. In an in vitro system, both vitamin E and rifampicin, a known stimulator of xenobiotic metabolism, activated the pregnane X receptor (PXR), an orphan nuclear receptor. PXR ...
Tópico(s): Pharmacogenetics and Drug Metabolism
2003 - Elsevier BV | Archives of Biochemistry and Biophysics
Retinoids, a group of structural and functional analogs of vitamin A, are known to regulate a large number of essential biological processes and to suppress carcinogenesis. The effects of retinoids are mainly mediated by nuclear retinoid receptors, which include retinoic acid receptors (RARs) and retinoid X receptors (RXRs). Each receptor has three subtypes (alpha, beta, and gamma) and each subtype has different isoforms. Retinoic acid receptor-beta (RAR-beta) has four isoforms that have different affinities ...
Tópico(s): Antioxidant Activity and Oxidative Stress
2006 - Elsevier BV | Cancer Letters
The founding member of the lipoprotein receptor family, low-density lipoprotein receptor (LDLR) plays a major role in the atherogenesis through the receptor-mediated endocytosis of LDL particles and regulation of cholesterol homeostasis. Since the discovery of the LDLR, many other structurally and functionally related receptors have been identified, which include low-density lipoprotein receptor-related protein (LRP)1, LRP5, LRP6, very low-density lipoprotein receptor, and apolipoprotein E receptor ...
Tópico(s): Antioxidant Activity and Oxidative Stress
2019 - Oxford University Press | Cardiovascular Research