Julia Schrankl, Michaela Fuchs, Katharina Broeker, Christoph Daniel, Armin Kurtz, Charlotte Wagner,
... are mediated mainly by ANG II type 1 (AT1) receptors. AT1 receptor expression has been reported for a variety of ... in the literature regarding the intrarenal distribution of AT1 receptors, this study aimed to obtain a comprehensive overview about the localization of AT1 receptor expression in mouse, rat, and human kidneys. Using ... mRNA expression in mouse, rat, and human kidneys. AT1 receptors were detected in mesangial cells and renin-producing ... rodents, late afferent and early efferent arterioles expressed AT1 receptor mRNA, but larger vessels of the investigated species ...
Tópico(s):
2021 - American Physical Society | AJP Renal Physiology
Satoru Eguchi, Tatsuo Kawai, Rosario Scalia, Victor Rizzo,
... salt and water reabsorption, are mediated through the AT1 receptor. The losartan-insensitive receptor was termed AT2 receptor, ... independently isolated cDNA (termed AGTR1) encoding the mammalian AT1 receptor.5,6 Subsequently, rat AT2 receptor cDNA (AGTR2) ... In the early 1990s, several studies reported that AT1 receptor elicits tyrosine phosphorylation of multiple proteins and activation ... of the concept that angiotensin II via the AT1 receptor has a direct action on cardiac myocytes, fibroblasts, ... the identification of common signaling mechanisms shared by AT1 receptor and a growth factor receptor that has an ...
Tópico(s): Apelin-related biomedical research
2018 - Lippincott Williams & Wilkins | Hypertension
Pablo Nakagawa, Curt D. Sigmund,
... vis-a-vis Ang-II/angiotensin type 1 (AT1) receptor versus Ang-(1–7)/Mas. The intricate neural ... by deoxycorticosterone acetate-salt through an Ang-II/AT1 receptor–dependent mechanism involving cAMP response element binding protein ... coordinate regulation. ACE2 overexpression in the PVN decreases AT1 receptor and ACE mRNA expression concomitant with Mas receptor ... enhanced baroreflex sensitivity concomitant with reduced renin and AT1 receptor expression in transgenic (mRen2) 27 hypertensive rats.76 AT1 receptor activation decreases ACE2 activity, whereas long-term blockade ...
Tópico(s): Cardiovascular, Neuropeptides, and Oxidative Stress Research
2017 - Lippincott Williams & Wilkins | Hypertension
N. H. Gonsai, Vishrant Amin, C. G. Mendpara, Robert C. Speth, Genevieve M Hale,
... mice) Assess the interaction of dopamine receptors with AT1 receptor expression in male and female mice from 6th ... and D4 wild-type littermates after injection of AT1 receptor antagonist (P < .05), but was more sustained in ... BP and is related to the activation of AT1 receptor in the brain. D4 receptor gene locus is ... well defined.4 With the administration of an AT1 receptor antagonist known as an angiotensin receptor blocker (ARB), ... are also hypertensive, and both kidney and brain AT1 receptors are increased in the D4 receptor knockout mouse. ...
Tópico(s): Electroconvulsive Therapy Studies
2017 - Wiley | Journal of Clinical Pharmacy and Therapeutics
Katrina M. Mirabito Colafella, A.H. Jan Danser,
... Ang) II, acting via its classical type 1 (AT1) receptor. Next, multiple novel angiotensin metabolites and receptors were ... and often opposing those of the Ang II–AT1 receptor pathway, for instance the Ang III–Ang II ... via Rho kinase activation,5 the latter involving AT1 receptors on paraventricular nucleus astrocytes.6 Leptin upregulated the brain RAS (ACE and AT1 receptors), thereby sensitizing the body to Ang II–induced ... plasma Ang II ratio decreased by >90% after AT1 receptor blockade suggest that the accumulation of plasma Ang ...
Tópico(s): Renin-Angiotensin System Studies
2017 - Lippincott Williams & Wilkins | Hypertension
Nathan P. Rudemiller, Steven D. Crowley,
... 2 angiotensin II receptors (AT1 or AT2). The AT1 receptor is a G-protein–coupled receptor expressed in ... throughout the body. Although the rodent expresses 2 AT1 receptor isoforms, AT1A and AT1B, the closest functional homolog to the human AT1 receptor in most rodent tissues is AT1A. The most ... appreciated functions of Ang II signaling via the AT1 receptor are to augment global vascular tone and to ... Ang II or by preventing activation of the AT1 receptor. These medications are global inhibitors in the sense ...
Tópico(s): Asthma and respiratory diseases
2016 - Lippincott Williams & Wilkins | Hypertension
Stefanie Frölich, Patrick Slattery, Dominique Thomas, Itamar Goren, Nerea Ferreirós, Boye L. Jensen, Rolf M. Nüsing,
... similar glomerular defects as telmisartan. Administration of the AT1 receptor agonist L162313 to COX-2-/- pups improved kidney ... COX-2-/- mice was reduced. Thus, angiotensin II-AT1–receptor signaling is necessary for COX-2–dependent normal ... similar glomerular defects as telmisartan. Administration of the AT1 receptor agonist L162313 to COX-2-/- pups improved kidney ... COX-2-/- mice was reduced. Thus, angiotensin II-AT1–receptor signaling is necessary for COX-2–dependent normal ... time provide evidence that administration of a selective AT1 receptor agonist is able to rescue nephrogenic defects and ...
Tópico(s): Pharmacogenetics and Drug Metabolism
2016 - Elsevier BV | Kidney International
Lodi C.W. Roksnoer, Richard van Veghel, René de Vries, Ingrid M. Garrelds, Usha M. Bhaggoe, Edith C. H. Friesema, Frank Leijten, Marko Poglitsch, Oliver Domenig, Marian C. Clahsen‐van Groningen, Ewout J. Hoorn, A.H. Jan Danser, Wendy W. Batenburg,
... of the neprilysin inhibitor thiorphan on top of AT1 receptor blockade with irbesartan versus vehicle in TGR(mREN2) ... dosing reveals additional cardioprotective effects on top of AT1 receptor blockade in renin-dependent hypertension. Neprilysin inhibitors prevent ... of the neprilysin inhibitor thiorphan on top of AT1 receptor blockade with irbesartan versus vehicle in TGR(mREN2) ... dosing reveals additional cardioprotective effects on top of AT1 receptor blockade in renin-dependent hypertension. Renin–angiotensin system ( ...
Tópico(s): Renin-Angiotensin System Studies
2015 - Elsevier BV | Kidney International
Ryan T. Kendall, Mi‐Hye Lee, Dorea L. Pleasant, Katherine M. Robinson, Dhandapani Kuppuswamy, Paul J. McDermott, Louis M. Luttrell,
... regulate the rate of protein translation. The angiotensin AT1 receptor has been shown to activate both ERK1/2 ... stimulation of mTOR-dependent protein translation by the AT1 receptor using HEK293 and primary vascular smooth muscle cell ... Nascent protein synthesis stimulated by both the canonical AT1 receptor agonist angiotensin II (AngII), and the arrestin pathway- ... p90 ribosomal S6 kinase (p90RSK). Thus, arrestins coordinate AT1 receptor regulation of ERK1/2 and Akt activity and ... results suggest that in vivo, arrestin pathway-selective AT1 receptor agonists may promote cell growth or hypertrophy through ...
Tópico(s): Protein Degradation and Inhibitors
2014 - Elsevier BV | Journal of Biological Chemistry
... the class of angiotensin II (AngII) type 1 (AT1) receptor antagonists that block the effects of AngII on ... effects. Losartan has known effects beyond antagonism of AT1 receptors, although this does not extend to antagonism of ... Therefore, the benefits of losartan administration infer that AT1 receptors are involved in these Fbn1 C1039G mice. Conversely, ... these were convincing preclinical data that antagonism of AT1 receptors would be a beneficial approach for treating aortic ... was greatly reinforced by the reported superiority of AT1 receptor blockade compared with β-adrenoceptor antagonism in Fbn1 ...
Tópico(s): Cardiovascular Issues in Pregnancy
2014 - Lippincott Williams & Wilkins | Arteriosclerosis Thrombosis and Vascular Biology
Yoshitaka Hirooka, Takuya Kishi, Koji Ito, Kenji Sunagawa,
... contain a high density of angiotensin type 1 (AT1) receptors.25 Therefore, these areas can access circulating angiotensin ... PVN–RVLM pathway is activated in association with AT1 receptor activation.2,17,23,26 Other brain sites, ... the pathogenesis of angiotensin II–induced hypertension.26 AT1 receptors and glutamatergic receptors in the RVLM support blood pressure in hypertensive rats.23,27 Because AT1 receptors in the brain are responsible for sympathoexcitation, which ... stress, obesity, and high-salt intake, activate the AT1 receptors responsible for autonomic functions.21 The role of ...
Tópico(s): Blood Pressure and Hypertension Studies
2013 - Lippincott Williams & Wilkins | Hypertension
Sara Conti, Paola Cassis, Ariela Benigni,
... AT2) receptors.1 Human cells express a single AT1 receptor, whereas 2 isoforms, AT1A and AT1B with 95% ... receptor, the closest murine homologue to the human AT1 receptor, predominates in most tissues, including heart, kidney, and ... systems. Circulating Ang II through activation of the AT1 receptor contributes to an increase in blood pressure and ... have been attributed to the activation of the AT1 receptor on T cells,7,8 although a recent ... AT2 receptor are opposite to those of the AT1 receptor. Early studies indicated a secondary role for the ...
Tópico(s): Renin-Angiotensin System Studies
2012 - Lippincott Williams & Wilkins | Hypertension
Július Benický, Roman Hafko, Enrique Sánchez-Lemus, Greti Aguilera, Juan M. Saavedra,
Commercially available Angiotensin II AT1 receptor antibodies are widely employed for receptor localization and quantification, but they have not been adequately validated. In this study, six commercially available AT1 receptor antibodies were characterized by established criteria: sc-1173 ... were unrelated to the presence or absence of AT1 receptors. The antibodies detected a 43 kDa band in ... corresponding to the predicted size of the native AT1 receptor. However, identical bands were observed in wild-type ...
Tópico(s): Coagulation, Bradykinin, Polyphosphates, and Angioedema
2012 - Springer Science+Business Media | Cellular and Molecular Neurobiology
Sung Tae Cho, Eun Young Park, Joon Chul Kim,
... factor (NGF) and the angiotensin II type 1 (AT1) receptors in the urothelium and the detrusor muscle in ... bladder outlet obstruction (BOO). To determine whether the AT1 receptor antagonist telmisartan alleviated the detrusor overactivity in rats ... levels and the cellular distribution of NGF and AT1 receptors were quantified by Western blot analysis and immunofluorescence ... expression and the immunoreactivity of NGF and the AT1 receptors were increased in the BOO group, compared with ... of NGF and AT1 were decreased. Conclusion The AT1 receptors may play a significant role in the pathogenesis ...
Tópico(s): Pelvic floor disorders treatments
2012 - Elsevier BV | Urology
... increased expression of the Ang II type 1 (AT1) receptor.3–5 Evidence suggests that cardiac Ang II ... chemoattractant protein-1 and macrophage infiltration. Heart-activated AT1 receptor levels were increased, along with expression of TGF- ... function were abolished by a subpressor dose of AT1 receptor blocker. Thus, the adverse cardiac remodeling of exaggerated ... with an angiotensin-converting enzyme (ACE) inhibitor or AT1 receptor blocker. Treatment was associated with decreased LV mass ... Enhanced remodeling was associated with enhanced expression of AT1 receptor and TGF-β1, as well as Smad and ...
Tópico(s): Apelin-related biomedical research
2011 - Lippincott Williams & Wilkins | Hypertension
F. Wei, Xiuqin Jia, Shuqin Yu, Yunjuan Gu, L. Wang, Xuming Guo, Mingchuan Wang, Fulong Zhu, Cheng Xu, Yuming Wei, Zhuo Zhou, Michael Fu, Yaling Liao,
Background Anti-angiotensin II receptor subtype 1 (AT1 receptor) autoantibodies have previously been shown in sera of hypertensive patients. This study assessed whether anti-AT1-receptor autoantibody in serum is correlated with the efficacy of an AT1-receptor blocker (ARB; candesartan)-based regimen in hypertensive patients ... of Optimal Treatment in Hypertensive Patients with Anti-AT1-Receptor Autoantibodies is a multicentre, randomised, blinded endpoint, open- ... mm Hg, p=0.023). In those anti-AT1 receptor autoantibody-positive hypertensive patients, the mean systolic BP ...
Tópico(s): Renin-Angiotensin System Studies
2011 - BMJ | Heart
Vienna E. Brunt, Christopher T. Minson,
... down the actions of ANG II type-1 (AT1) receptors, which are of particular interest from a clinical perspective. The authors have previously shown AT1 receptors to play a role in the diminished thermal ... with postural tachycardia syndrome (10). It is possible AT1 receptors may also contribute to the attenuated thermal hyperemia ... included two enzymes through which the actions of AT1 receptors are mediated, NADPH oxidase and xanthine oxidase (XO), ... acting here. In addition, these results indicate that AT1 receptors normally modulate vasodilation in healthy subjects. AT1 receptors ...
Tópico(s): Infrared Thermography in Medicine
2011 - American Physiological Society | Journal of Applied Physiology
... M. Hussain T. Lokhandwala M.F. Angiotensin II AT1 receptor/signaling mechanisms in the biphasic effect of the ... endosomes during Ang II-induced hypertension: role of AT1 receptor.Hypertension. 2002; 39: 116-121Crossref PubMed Scopus (126) ... et al.Angiotensin II signal transduction through the AT1 receptor: novel insights into mechanisms and pathophysiology.Clin Sci ( ... et al.Angiotensin II signal transduction through the AT1 receptor: novel insights into mechanisms and pathophysiology.Clin Sci ( ... Ang II-infused rats were treated with the AT1 receptor blocker losartan to determine the role of AT1 ...
Tópico(s): Ion Transport and Channel Regulation
2011 - Elsevier BV | Kidney International
Jasenka Zubcevic, Hidefumi Waki, Mohan K. Raizada, Julian F. R. Paton,
... and TNF-α. The Ang II type 1 (AT1) receptor blocker, candesartan, produced antihypertensive effects and decreases in ... of neurogenic hypertension. Angiotensin (Ang) II type 1 (AT1) receptors on subfornical organ (SFO)/organum vasculosum of lamina ... generated within the PVN can also activate neuronal AT1 receptors to compliment changes in neuronal activity. An imbalance ... pathophysiology. These neuralvascular signals are further perpetuated by AT1 receptor–mediated changes in cerebral blood vessels, interrupting the ...
Tópico(s): Renin-Angiotensin System Studies
2011 - Lippincott Williams & Wilkins | Hypertension
L. Gabriel Navar, Hiroyuki Kobori, M. Prieto, Romer A. Gonzalez‐Villalobos,
... adult kidneys is the Ang II type 1 (AT1) receptor,5 although Ang II type 2 receptors are ... role in renin synthesis.17 Nevertheless, overall renal AT1 receptor abundance far exceeds Ang II type 2 receptor levels,5,18 and AT1 receptors are widely distributed on luminal membranes throughout the ... ducts (CDs).5,19 The regulation of intrarenal AT1 receptors is complex, because vascular AT1 receptors are downregulated, whereas tubular AT1 receptors are either sustained or upregulated by elevated Ang II levels.1,6,20,21The presence of AT1 receptors on luminal membranes of various nephron segments generated ...
Tópico(s): Cardiovascular, Neuropeptides, and Oxidative Stress Research
2011 - Lippincott Williams & Wilkins | Hypertension
... of dopamine receptors inhibits catecholamine and renin release*, AT1 receptor (and probably α-adrenergic)–mediated sodium reabsorption. The ... hypothalamus, which becomes more evident with blockade of AT1 receptors.43 Inhibition of angiotensin-converting enzyme also increases ... very evident in receptor-deficient mice. Blockade of AT1 receptors results in a decrease in blood pressure that ... with angiotensin II, including a negative regulation of AT1 receptor action/expression and a positive regulation of AT2 ...
Tópico(s):
2010 - Lippincott Williams & Wilkins | Hypertension
Ariela Benigni, Paola Cassis, Giuseppe Remuzzi,
... et al, 2009). Human cells express a single AT1 receptor, while two isoforms, AT1A and AT1B with 95% ... receptor, the closest murine homologue to the human AT1 receptor, is expressed in the kidney, heart, brain adrenal ... receptor CCR2. Modulation of MCP-1/CCR2 via AT1 receptor blockade reduces vessel inflammation in these rats (Dai ... and vascular smooth muscle cells, Ang II via AT1 receptor signalling stimulates TLR-4 expression, which promotes cellular ... 2009). During inflammation, Ang II acts via its AT1 receptor to stimulate cytoskeletal rearrangements in T cells and ...
Tópico(s): Apelin-related biomedical research
2010 - Springer Nature | EMBO Molecular Medicine
Ivana Domazet, Stéphane Martin, Brian J. Holleran, M.D. Morin, Patrick Lacasse, Pierre Lavigne, Emanuel Escher, Richard Leduc, Gaétan Guillemette,
... the activation of the angiotensin II Type 1 (AT1) receptor, which belongs to the G protein-coupled receptor superfamily. Like other G protein- coupled receptors, the AT1 receptor possesses seven transmembrane domains that provide structural support ... within the water-accessible binding pocket of the AT1 receptor. Interestingly, this pattern of acquired MTSEA sensitivity was ... reporter cysteines engineered in a constitutively active N111G-AT1 receptor background. Indeed, mutant I201C-N111G-AT1 became more ...
Tópico(s): Neuropeptides and Animal Physiology
2009 - Elsevier BV | Journal of Biological Chemistry
Ivana Domazet, Brian J. Holleran, Stéphane Martin, Pierre Lavigne, Richard Leduc, Emanuel Escher, Gaétan Guillemette,
... the activation of the angiotensin II type-1 (AT1) receptor, which belongs to the G protein-coupled receptor superfamily. Like other G protein-coupled receptors, the AT1 receptor possesses seven transmembrane domains that provide structural support ... the formation of the binding pocket of the AT1 receptor, we used the substituted cysteine accessibility method. All ... within the water-accessible binding pocket of the AT1 receptor. Interestingly, this pattern of acquired MTSEA sensitivity was ... reporter cysteines engineered in a constitutively active N111G-AT1 receptor background. Indeed, mutant D74C-N111G-AT1 became insensitive ...
Tópico(s): Computational Drug Discovery Methods
2009 - Elsevier BV | Journal of Biological Chemistry
Alain Dupont, Rui Yang, Ilse Smolders, Patrick Vanderheyden,
... of Ang IV are mediated through stimulation of AT1 receptors [7–9]. We indeed recently demonstrated that i. ... rats, an effect that was abolished by selective AT1 receptor blockade [9]. Direct central Ang IV administration also ... outflow and blood pressure through stimulation of brain AT1 receptors. Chronic elevation of Ang IV in the brain ... inhibited by i.c.v. injection of the AT1 receptor antagonist candesartan (De Bundel, personal communication). Fyhrquist and ... antagonist, divalinal-Ang IV [15], but not by AT1 receptor antagonists, it indeed indicates the involvement of IRAP/ ...
Tópico(s):
2009 - Wiley | Journal of Internal Medicine
Chang-Ping Hu, Bum‐Yong Kang, Judit Megyesi, Gur P. Kaushal, Robert L. Safirstein, Jawahar L. Mehta,
... Baudry C. et al.Role of angiotensin II AT1 receptor activation in cardiovascular diseases.Kidney Int. 2008; 74: ... studies showed that Ang II through type 1 (AT1) receptor activation stimulates LOX-1 expression.7.Chen J. ... Google Scholar In turn, LOX-1 activation upregulates AT1 receptor expression.8.Li D. Saldeen T. Romeo F. ... actions of Ang II have been attributed to AT1 receptor activation.6.Billet S. Aguilar F. Baudry C. et al.Role of angiotensin II AT1 receptor activation in cardiovascular diseases.Kidney Int. 2008; 74: ...
Tópico(s): Neutrophil, Myeloperoxidase and Oxidative Mechanisms
2009 - Elsevier BV | Kidney International
... angiotensin II mediated through angiotensin II type 1 (AT1) receptors that have received the greatest emphasis. Accordingly, current ... management guidelines emphasize angiotensin-converting enzyme inhibitors or AT1 receptor blockers as specific antiproteinuric and renoprotective therapy independent ... is generally postulated to antagonize the effects of AT1 receptor activation,2.Siragy H.M. AT1 and AT2 ... independently beneficial AT2 effect. A plethora of potential AT1 receptor-mediated deleterious mechanisms have been postulated through investigations ...
Tópico(s): Hormonal Regulation and Hypertension
2009 - Elsevier BV | Kidney International
Yayoi Izu, Fumitaka Mizoguchi, Aya Kawamata, Tadayoshi Hayata, Testuya Nakamoto, Kazuhisa Nakashima, Tadashi Inagami, Yoichi Ezura, Masaki Noda,
... actions of Ang II appear to be through AT1 receptors. In bone tissue, Ang II was reported to promote bone resorption via the AT1 receptor in cell culture system and in ovariectomized mice ... 2475Crossref PubMed Scopus (230) Google Scholar). Expression of AT1 receptor was observed in cultured osteoblasts (21Bandow K. Nishikawa ... II inhibit differentiation and bone formation via the AT1 receptor in rat calvarial osteoblastic cells (22Hagiwara H. Hiruma ... Scopus (98) Google Scholar). In contrast to the AT1 receptor, no significant effect was observed in cells by ...
Tópico(s): Vitamin D Research Studies
2008 - Elsevier BV | Journal of Biological Chemistry
Thomas M. Coffman, Steven D. Crowley,
... recognized functions of the RAS are mediated by AT1 receptors. Gene targeting studies confirmed these conclusions.8 AT1 receptors from a number of species have been cloned, ... identified in rat and mouse.11 The murine AT1 receptors are products of separate genes and share substantial ... the closest murine homologue to the single human AT1 receptor. Understanding the physiological functions of this predominant murine AT1 receptor has been a major focus of our work. ... altered salt and water excretion by the kidney.AT1 Receptors Are Expressed in Tissue Compartments Involved in Blood ...
Tópico(s): Blood Pressure and Hypertension Studies
2008 - Lippincott Williams & Wilkins | Hypertension
Nancy J. Brown, Jennifer Bradford, Z. Wang, William Lea, Lijun Ma, Ji Ma, Douglas E. Vaughan, Agnes B. Fogo,
... 2520Crossref PubMed Scopus (300) Google Scholar In contrast, AT1 receptor antagonism decreases PAI-1 expression in astrocytes, VSMCs, ... renal PAI-1 expression in vivo through the AT1 receptor or via conversion of Ang II to Ang ... the AT4 receptor. We have reported previously that AT1 receptor antagonism abolished acute Ang II-induced hepatic, renal, ... Text PDF PubMed Scopus (144) Google Scholar Likewise, AT1 receptor antagonism decreased Ang II-induced aortic and cardiac ... of these studies delineated the role of specific AT1 receptor subtypes in Ang II-stimulated PAI-1 expression. ...
Tópico(s): Coagulation, Bradykinin, Polyphosphates, and Angioedema
2007 - Elsevier BV | Kidney International