Hsi-Hsien Lin, G. Chang, John Q. Davies, Martin Stacey, James Harris, Siamon Gordon,
... endoplasmic reticulum; CM, conditioned medium; CL, cell lysate; GPS-receptor, GPS motif-containing receptor; GFP, green fluorescent protein. ... endoplasmic reticulum; CM, conditioned medium; CL, cell lysate; GPS-receptor, GPS motif-containing receptor; GFP, green fluorescent protein. ( ... proteolytic cleavage of the GPS motif-containing receptors (GPS-receptors) is a TM-independent process and that the ... we first compared the GPS motifs of all GPS-receptors that are known to be processed (Fig. 1B). ... the GPS cleavage site and suggest that all GPS-receptors probably undergo the same proteolytic process. To unveil ...
Tópico(s): Adenosine and Purinergic Signaling
2004 - Elsevier BV | Journal of Biological Chemistry
David Vorchheimer, Richard Becker,
... which coagulation enzymes can function efficiently, whereas glycoprotein (GP) receptors on the platelet's surface act as points ... Google Scholar There it engages the P-selectin GP 1 receptor expressed on leukocytes, enabling the leukocyte to roll, ...
Tópico(s): Platelet Disorders and Treatments
2006 - Elsevier BV | Mayo Clinic Proceedings
Derya Özsavcı, Turay Yardımcı, Gülderen Yanıkkaya Demirel, Emel Ekşioğlu, Fikriye Uras, Ekin Önder,
In this study, platelet glycoprotein (Gp) receptor numbers were measured by a flow cytometric assay using Cytoquant Gp in seven hypercholesterolemic and five normal subjects. Thrombin receptor agonist ... was used to activate platelets. In hypercholesterolemia the Gp receptor numbers per resting platelet were found to be: ...
Tópico(s): Cell Adhesion Molecules Research
2002 - Informa | Platelets
David A. Crosby, Alastair W. Poole,
... to which platelets adhere through several surface glycoprotein (GP) receptors. These two adhesion molecules induce signaling events in ... Lyn have been shown to associate with the GP Ib receptor complex and to be essential for signaling downstream ... assayed in vitro. Binding of vWF to the GP Ib-V-IX receptor complex and of collagen to GP VI induces a signaling cascade in platelets involving ...
Tópico(s): Chronic Lymphocytic Leukemia Research
2002 - Elsevier BV | Journal of Biological Chemistry
... Willebrand factor) via interactions with platelet membrane glycoprotein (GP) receptors. This interaction produces an intracellular signal that activates platelets to increase expression of a specific GP receptor, GPIIb/IIIa, with a high affinity for fibrinogen ...
Tópico(s): Heparin-Induced Thrombocytopenia and Thrombosis
2001 - Lippincott Williams & Wilkins | Neurology
Jane F. Arthur, Yuan Shen, Elizabeth E. Gardiner, Lorraine Coleman, Dermot Kenny, Robert K. Andrews, Michael C. Berndt,
... one consequence of ligand engagement of platelet glycoprotein (GP) receptors GPIb‐IX‐V and GPVI, which bind VWF/ ... one consequence of ligand engagement of platelet glycoprotein (GP) receptors GPIb‐IX‐V and GPVI, which bind VWF/ ...
Tópico(s): Blood disorders and treatments
2010 - Elsevier BV | Journal of Thrombosis and Haemostasis
Paresh Dandona, Kuldip Thusu, Usha Khurana, John Love, Ahmad Aljada, Shaker A. Mousa,
... dependent inhibition of PSC. Finally, we investigated whether GP receptor which binds fibrinogen was involved in PSC; DMP ... methyl-benzoic acid], methanesulfonic acid salt] a potent GP receptor antagonist was without any effect on PSC. We conclude that PSC is a calcium, calmodulin and protein kinase C dependent process like platelet aggregation but that it does not require extracellular calcium or the participation of platelet GP complex.
Tópico(s): Nitric Oxide and Endothelin Effects
1996 - Elsevier BV | Thrombosis Research
Hans Peter Wendel, Hans‐Joachim Schulze, W. Heller, Hans-Martin Hoffmeister,
... the protective capacity of aprotinin to the glycoprotein (GP) receptors of the platelet membrane.Experimental in vitro study. ... to evaluate the affinity of aprotinin for the GP receptors of the platelet membrane. The affinity appeared in ...
Tópico(s): Platelet Disorders and Treatments
1999 - Elsevier BV | Journal of Cardiothoracic and Vascular Anesthesia
Louis T. DiFazio, C. Stratoulias, Ralph S. Greco, Beatrice Haimovich,
... monoclonal antibodies (mAbs) against specific platelet surface glycoprotein (GP) receptors. Purified 51 Cr-labeled human platelets in plasma- ... factor (vWF), and fibronectin receptor]; mAb 6D1 (anti-GP Ib-IX; vWF receptor); mAb IV.3 (anti-FcγRII; IgG receptor); polyclonal antiserum A108 or mAb BIIG4 (anti-GP Ic-IIa; fibronectin receptor). Antibody-treated platelets were added to microtiter wells ...
Tópico(s): Hemostasis and retained surgical items
1994 - Elsevier BV | Journal of Surgical Research
Todd L. Kiefer, Richard C. Becker,
... on-and-off" or "start-and-stop" platelet GP Ib receptor—endothelial VWF interactions involving the formation of multiple ... undergoes conformational changes and initially binds to the GP Ib receptor as part of the tethering stage of platelet ... discussion of the VWF. Additional ligands for the GP Ib receptor include thrombin, P-selectin, factor XI, factor XII, ... associated with trauma.30Experimental ModelsThe interaction of the GP Ib receptor with VWF is an early and pivotal step ... The available data suggest that ligands for the GP Ib receptor, other than VWF, may play a critical role ...
Tópico(s): Antiplatelet Therapy and Cardiovascular Diseases
2009 - Lippincott Williams & Wilkins | Circulation
Nikolaos J. Skubas, George J. Despotis, Jon J. Vlasnic, Marc R. Moon,
... myocardial infarction. Activation of the platelet IIb/IIIa GP receptor represents a crucial step in platelet aggregation, and 80–100% blockade of this receptor should completely suppress platelet aggregation. Therefore, potent platelet inhibitors, such as the intravenous GP IIb/IIIa inhibitors have been developed, and their ... blood usage was associated with use of the GP IIb/IIIa inhibitor abciximab, especially if surgery was performed within 24 h after receiving the medication. 8However, these findings have not been universal. 9Platelet transfusions, which will reduce the drug's receptor occupancy on platelet surfaces to less than the ...
Tópico(s): Venous Thromboembolism Diagnosis and Management
1999 - Lippincott Williams & Wilkins | Anesthesiology
Sapna Devi, Michael Kuligowski, Rain Kwan, Erik Westein, Shaun P. Jackson, A. Richard Kitching, Michael J. Hickey,
... platelets express a wide range of adhesive glycoprotein (GP) receptors with the potential to mediate platelet adhesion in ... improved outcome in acute murine stroke by inhibiting GP IIb/IIIa receptor-mediated platelet aggregation.J Clin Invest. 1998; 102: ...
Tópico(s): Renal Diseases and Glomerulopathies
2010 - Elsevier BV | American Journal Of Pathology
Esther Ndungo, Andrew S. Herbert, Matthijs Raaben, Gregor Obernosterer, Rohan Biswas, Emily Happy Miller, Ariel S. Wirchnianski, Jan E. Carette, Thijn R. Brummelkamp, Sean P. J. Whelan, John M. Dye, Kartik Chandran,
... findings, revealing that this residue dips into the GP receptor-binding pocket and is therefore critical to the binding interface. Consequently, this otherwise well-conserved residue in vertebrate species influences the ability of reptilian NPC1 proteins to bind to EBOV GP, thereby affecting viral host range in reptilian cells.
Tópico(s): Viral gastroenteritis research and epidemiology
2016 - American Society for Microbiology | mSphere
... is related to platelet GP IIb/IIIa and GP Ib receptors, four series of experiments were performed on blood ... MAb 6D1), the latter an antagonist at the GP Ib receptor. In conclusion, the potentiation of collagen-induced platelet ... effect is related to activation of the platelet GP IIb/IIIa receptor complex.
Tópico(s): Blood groups and transfusion
1992 - Elsevier BV | Thrombosis Research
Rüdiger Klein, Fabienne Lamballe, Sherri Bryant, Mariano Barbacid,
... 125I-labeled BDNF from binding to cells expressing gp 145trkB receptors, induces their rapid phosphorylation on tyrosine residues, and ... sympathetic-like neurons only if they ectopically express gp 145trkB receptors. None of these biochemical or biological effects could ... with at least partially distinct domains within the gp 145trkB receptor.
Tópico(s): Virus-based gene therapy research
1992 - Cell Press | Neuron
Therese Reignier, Jill Oldenburg, M. FLANAGAN, Genevieve A. Hamilton, Vanessa K. Martin, Paula M. Cannon,
... viruses. Although many viral factors in addition to GP receptor use and tropism determine whether a virus is able to cause disease in humans, our analysis of the WWAV GP does not support the idea that WWAV is ...
Tópico(s): Mosquito-borne diseases and control
2007 - Elsevier BV | Virology
Tomoshige Kino, George P. Chrousos,
... PubMed Scopus (737) Google Scholar, 22Vottero A Chrousos GP. Glucocorticoid receptor beta: view I.Trends Endocrinol Metab. 1999; 10: ... b.25Kino T Slobodskaya O Pavlakis GN Chrousos GP. Nuclear receptor coactivator p160 proteins enhance the HIV-1 long ... increasing glucocorticoid activity.3Bamberger CM Schulte HM Chrousos GP. Molecular determinants of glucocorticoid receptor function and tissue sensitivity to glucocorticoids.Endocr Rev. ... H Hagelstein MT Louis E Dewe W Chrousos GP et al.Tumor necrosis factor alpha decreases, and interleukin-10 increases, the sensitivity of human monocytes to dexamethasone: potential regulation of the glucocorticoid receptor.J Clin Endocrinol Metab. 1999; 84: 2834-2839Crossref ...
Tópico(s): Cytokine Signaling Pathways and Interactions
2002 - Elsevier BV | Journal of Allergy and Clinical Immunology
Simon F. De Meyer, Frederik Denorme, Friederike Langhauser, Eva Geuß, Felix Fluri, Christoph Kleinschnitz,
... vWF)/ultralarge (UL)-vWF via their platelet glycoprotein (GP) Ibα receptor. On this initial adhesion step, binding of exposed ... platelet surface. Upon activation of the platelet, the GP IIb/IIIa receptor shifts from an inactive state to an active ... GP IIb/IIIa. There is some evidence that GP IIb/IIIa receptors can be acquired by neutrophils via platelet-derived microparticles.81 Acquired GP IIb/IIIa receptors colocalize with β2-integrins and cooperate with nuclear factor-κB activation, implicating that GP IIb/IIIa receptors mediate neutrophil-induced inflammation. Interestingly, GP IIb/IIIa ...
Tópico(s): Atherosclerosis and Cardiovascular Diseases
2016 - Lippincott Williams & Wilkins | Stroke
Rachel Kaletsky, Graham Simmons, Paul Bates,
... binding. The influence of CatL in Ebola virus GP receptor binding should be useful in future studies characterizing ...
Tópico(s): Viral gastroenteritis research and epidemiology
2007 - American Society for Microbiology | Journal of Virology
Alexander Vizurraga, Rashmi Adhikari, Jennifer Yeung, Maiya Yu, Gregory G. Tall,
... cleavage is typically attributed to alterations of the GPS; receptors lacking a basic residue at the P2 position ( ... activated in both manners. Orthosteric agonism is a receptor activation model that depends on the action of the AGPCR tethered agonist. The most important residues, or the core of the tethered agonist, are the seven residues located immediately C-terminal to the GPS. These residues mostly overlap with β-strand 13, ...
Tópico(s): Cell Adhesion Molecules Research
2020 - Elsevier BV | Journal of Biological Chemistry
Pier Luigi Canonico, Antonella Favit, Maria Vincenza Catania, Ferdinando Nicoletti,
... selective for a specific glutamate‐phosphoinositide receptor subtype (GP 2 receptor) activated by glutamate and quis‐qualate. TPA was ... methyl‐d‐aspartate, a selective agonist of the GP 1 receptor. Phorbol diesters and DOG attenuated the stimulation of ... particular molecular forms of phosphoinositidase C associated with GP 2 or muscarinic cholinergic receptors.
Tópico(s): Natural product bioactivities and synthesis
1988 - Wiley | Journal of Neurochemistry
Christian Seidl, Jan Siehl, C.M. Kirchmaier, Erhard Seifried,
... was to analyze the RNA level of glycoprotein (GP) receptors in platelets. We have therefore established a quantitative ... blood donors. In parallel experiments the number of GP cell surface receptors was measured by flow-cytometric analysis and correlated with the GP-specific RNA content. This method may be useful ...
Tópico(s): Glycosylation and Glycoproteins Research
1997 - Karger Publishers | Pathophysiology of Haemostasis and Thrombosis
... metabolizing enzymes (phospholipases, thromboxane synthase), and other membrane GP receptors involved in initiation of platelet activation. The antiplatelet ... IIIa inhibitors are unknown, but polymorphisms in the GP IIb/IIIa complex could potentially contribute to relative resistance to these drugs.10The thienopyridines ticlopidine and clopidogrel inhibit platelet function by irreversibly blocking he binding of adenosine diphosphate (ADP) to its P2Y12 (P2Yac) platelet receptor. Both of these drugs are inactive and require ...
Tópico(s): Platelet Disorders and Treatments
2003 - Lippincott Williams & Wilkins | Circulation
Colette Dezutter‐Dambuyant, Didier Schmitt, Nathalie Dusserre, Daniel Hanau, Hanno V.J. Kolbe, Marie‐Paule Kieny, Jean‐Pierre Cazenave, Daniel Schmitt, Jean‐Louis Pasquali, René Olivier, Louis Gazzolo, J Thivolet,
... We show that a proportion of gp 120/gp 160s‐receptor complexes enters Langerhans cells by a process identified ... HIV‐1) are trypsin sensitive. A burst of gp 120 receptor expression was detected on 1‐day cultured Langerhans cells while CD4 antigens disappeared. These findings lead to the most logical conclusion that binding of gp 120/gp 160s is due to the presence ...
Tópico(s): Herpesvirus Infections and Treatments
1991 - Wiley | The Journal of Dermatology
Julia Nehls, Ramona Businger, Markus Hoffmann, Constantin Brinkmann, Birgit Fehrenbacher, Martin Schaller, Brigitte Maurer, Caroline Schönfeld, Daniela Kramer, Stephan Hailfinger, Stefan Pöhlmann, Michael Schindler,
... CD317) in this process. Residues in the EBOV-GP receptor-binding domain (RBD) promote GP-virosome secretion, while tetherin suppresses GP-virosomes by ...
Tópico(s): COVID-19 epidemiological studies
2019 - Cell Press | Cell Reports
... for Using in Positioning whit a Single Frequency GPS Receptor Abstract The largest error source in the positioning and navigation with GPS, in the absence of the selective availabity (SA), ...
Tópico(s): Geophysics and Gravity Measurements
2005 - UNIVERSIDADE FEDERAL DO PARANÁ | Boletim de Ciências Geodésicas
Alan T. Nurden, Paquita Nurden,
... we indicate how research into platelet membrane glycoprotein (GP) receptors is yielding vital information on the mechanisms of ... while others are widely distributed in mammalian tissues. GP Ib-IX complexes are responsible for the high-shear-rate-dependent adhesion of platelets to von Willebrand factor (vWF) exposed within the subendothelium of damaged vessels. Other adhesion receptors include members of the VLA subclass of the ... including the highly important and recently cloned thrombin receptor, have seven transmembrane domains and possess highly selective agonist-binding determinants. Finally, we highlight platelet aggregation and the role of GP IIb-IIIa complexes which, following platelet activation, bind ...
Tópico(s): Cell Adhesion Molecules Research
1993 - Elsevier BV | Baillière s Clinical Haematology
Gerald Soslau, Reiner Class, Doris A. Morgan, Carolyn Foster, Susan T. Lord, Patrizia Marchese, Zaverio M. Ruggeri,
... 638-647Crossref PubMed Scopus (120) Google Scholar). The GP Ib receptor also possesses a thrombin binding site that may ... SCH203099 plus ATAP-2-treated platelets indicates that GP Ib is the second α-thrombin receptor (Fig. 1 E (g)). The potential presence of ... 7 min (Fig. 2 B). We reasoned that GP Ib may be the third thrombin receptor that, along with PAR-1, is involved in ...
Tópico(s): Heparin-Induced Thrombocytopenia and Thrombosis
2001 - Elsevier BV | Journal of Biological Chemistry
Normaiza Zamri, Naoya Masuda, Fumie Oura, Yukiko Yajima, Hiroshi Nakada, Yoko Fujita‐Yamaguchi,
... cancer cells by binding to the 110 kDa GP receptor.Inhibition of growth by MLS128 did not appear ...
Tópico(s): Genetic factors in colorectal cancer
2012 - | BioScience Trends
Nicholas J. Lennemann, Andrew S. Herbert, Rachel B. Brouillette, Bethany A. Rhein, Russell A. Bakken, Katherine J Perschbacher, Ashley L. Cooney, Catherine L. Miller-Hunt, Patrick Ten Eyck, Julia E. Biggins, Gene G. Olinger, John M. Dye, Wendy Maury,
... thought to shield conserved regions of the EBOV GP receptor-binding domain (RBD), thereby blocking epitopes within the RBD, we also tested whether VSVΔG bearing EBOV GPs that lack GP1 N-linked glycans provided effective ...
Tópico(s): Virology and Viral Diseases
2017 - American Society for Microbiology | Journal of Virology