Produção Nacional
Revisado por pares
Nádia Maria Volpato, Regina Lengruber Silva, Ana Paula Pereira de Brito, José Carlos Saraiva Gonçalves, Mário Vaisman, François Noël,
In a previous study aimed to compare the bioavailability of two levothyroxine tablets, we found a good relation between their pharmacokinetics parameters and dissolution profiles, employing the USP dissolution conditions in use at that time (24th edition). Despite the formulations were considered bioequivalent, the test product presented values of AUC and concentrations at steady-state significantly lower (about 10%) than the reference ones. The purpose of the present study was to evaluate if the ...
Tópico(s): Pharmaceutical studies and practices
2004 - Elsevier BV | European Journal of Pharmaceutical Sciences
Produção Nacional
Revisado por pares
G. L. Volpato, Cristiane Regina do Amaral Duarte, Ana Carolina Luchiari,
We investigated the effects of environmental color on the reproductive behavior of Nile tilapia, Oreochromis niloticus. Two environmental colors were tested by covering the aquarium (60 x 60 x 40 cm) with white (12 groups) or blue (13 groups) cellophane and observing reproductive behavior in groups of 2 males (10.27 ± 0.45 cm) and 3 females (10.78 ± 0.45 cm) each. After assignment to the respective environmental color (similar luminosity = 100 to 120 Lux), the animals were observed until reproduction (identified ...
Tópico(s): Fish biology, ecology, and behavior
2004 - Associação Brasileira de Divulgação Científica | Brazilian Journal of Medical and Biological Research
Produção Nacional
Mário Vaisman, Luciana Diniz Carneiro Spina, Leonardo Eksterman, Mário Santos, Jaderson Lima, Nádia Maria Volpato, Regina Silva, Ana Maria de Brito, François Noël,
The aim of the present study was to evaluate the bioequivalence and thera peutic equivalence of the two most com monly prescribed L thyroxine (monso dium L thyroxine hydrate, CAS 25416-65-3) formulations in Brazil in patients treated for hypothyroidism. Twenty four patients received 100 µg L thyroxine daily of either Puran T4® (test) or the Brazilian reference formulation (refer ence) during 42 days, in a two period crossover design. Serum samples ob tained over a 24 h interval were analyzed for their ...
Tópico(s): Pituitary Gland Disorders and Treatments
2011 - Thieme Medical Publishers (Germany) | Arzneimittelforschung
Produção Nacional
Revisado por pares
Enilze de Souza Nogueira Volpato, Marluci Betini, Regina El Dib,
Abstract Background A high‐quality electronic search is essential in ensuring accuracy and completeness in retrieved records for the conducting of a systematic review. Objective We analysed the available sample of search strategies to identify the best method for searching in Medline through PubMed, considering the use or not of parenthesis, double quotation marks, truncation and use of a simple search or search history. Methods In our cross‐sectional study of search strategies, we selected and ...
Tópico(s): Academic Writing and Publishing
2013 - Wiley | Journal of Evaluation in Clinical Practice
Produção Nacional
Revisado por pares
G. L. Volpato, Ana Carolina Luchiari, Cristiane Regina do Amaral Duarte, Rodrigo Egydio Barreto, Guilherme Corrêa Ramanzini,
We investigated the association of eye color with the dominant-subordinate relationship in the fish Nile tilapia, Oreochromis niloticus. Eye color pattern was also examined in relation to the intensity of attacks. We paired 20 size-matched fish (intruder: 73.69 11.49 g; resident: 75.42 8.83 g) and evaluated eye color and fights. These fish were isolated in individual aquaria for 10 days and then their eye color was measured 5 min before pairing (basal values). Twenty minutes after pairing, eye color ...
Tópico(s): Aquaculture disease management and microbiota
2003 - Associação Brasileira de Divulgação Científica | Brazilian Journal of Medical and Biological Research
Produção Nacional
Revisado por pares
Giandra Volpato, Eliane M.Z. Michielin, Sandra Regina Salvador Ferreira, José Carlos Cunha Petrus,
The objective of this investigation was to study the kinetics of NaCl (sodium chloride) diffusion in chicken breast during curing process. By means of experimental planning, tests were carried out to optimise the process variables: concentrations of NaCl, phosphate and dextrose in the curing brine and the process temperature. Based on the improvement of brine gain during curing and reducement of losses during cooking, four conditions were determined to assess the kinetics of curing. The analytical ...
Tópico(s): Advanced Chemical Sensor Technologies
2006 - Elsevier BV | Journal of Food Engineering
Produção Nacional
Revisado por pares
Aristides Volpato Cordioli, Elizeth Heldt, Daniela Braga Bochi, Regina Margis, Marcelo Basso de Sousa, J Tonello, Betina Teruchkin, Flávio Kapczinski,
Objective: To develop a cognitive-behavioral group therapy protocol and to verify its efficacy to reduce obsessive-compulsive symptoms. Methods: An open clinical trial with 32 obsessive-compulsive patients was performed, in which a cognitive-behavioral group therapy protocol of 12 weekly sessions of two hours, in 5 consecutive groups, was applied. The severity of symptoms was rated with the Yale-Brown Obsessive-Compulsive (Y-BOCS), Hamilton Anxiety (HAM A) and Hamilton Depression (HAM D) scales. The ...
Tópico(s): Eating Disorders and Behaviors
2002 - Associação Brasileira de Psiquiatria | Brazilian Journal of Psychiatry
Produção Nacional
Revisado por pares
Aristides Volpato Cordioli, Elizeth Heldt, Daniela Braga Bochi, Regina Margis, Marcelo Basso de Sousa, J Tonello, Gisele Gus Manfro, Flávio Kapczinski,
The present study was designed to verify the efficacy of cognitive-behavioral group therapy (CBGT) in reducing obsessive-compulsive symptoms and the intensity of overvalued ideas, as well as in improving the patient's quality of life.Forty-seven patients meeting DSM-IV criteria for obsessive-compulsive disorder (OCD) were randomly assigned to either 12 weekly CBGT sessions or a waiting list (control group). Treated patients were followed for three months.There was a significant reduction in the Yale- ...
Tópico(s): Body Image and Dysmorphia Studies
2003 - Karger Publishers | Psychotherapy and Psychosomatics
Produção Nacional
Norma Sueli Pinheiro Módolo, Marília Pinheiro Módolo, Marcos A Marton, Enilze de Souza Nogueira Volpato, Vinícius Monteiro Arantes, Paulo do Nascimento, Regina El Dib,
Background This is an update of a Cochrane Review first published in The Cochrane Library, Issue 2, 2008. The technique called one‐lung ventilation can confine bleeding or infection to one lung, prevent rupture of a lung cyst or, more commonly, facilitate surgical exposure of the unventilated lung. During one‐lung ventilation, anaesthesia is maintained either by delivering an inhalation anaesthetic to the ventilated lung or by infusing an intravenous anaesthetic. It is possible that the method chosen ...
Tópico(s): Anesthesia and Sedative Agents
2013 - Elsevier BV | Cochrane library
Marco Maspero, Daniela Volpato, Davide Cirillo, Natalia Yuan Chen, Regina Messerer, Christoph Sotriffer, Marco De Amici, Ulrike Holzgrabe, Clelia Dallanoce,
We synthesized a set of new hybrid derivatives (7-C8, 7-C10, 7-C12 and 8-C8, 8-C10, 8-C12), in which a polymethylene spacer chain of variable length connected the pharmacophoric moiety of xanomeline, an M1/M4-preferring orthosteric muscarinic agonist, with that of tacrine, a well-known acetylcholinesterase (AChE) inhibitor able to allosterically modulate muscarinic acetylcholine receptors (mAChRs). When tested in vitro in a colorimetric assay for their ability to inhibit AChE, the new compounds showed ...
Tópico(s): Computational Drug Discovery Methods
2020 - Elsevier BV | Bioorganic Chemistry
Daniela Volpato, Michael Kauk, Regina Messerer, Marcel Bermúdez, Gerhard Wolber, Andreas Böck, Carsten Hoffmann, Ulrike Holzgrabe,
The muscarinic M1 acetylcholine receptor is an important drug target for the treatment of various neurological disorders. Designing M1 receptor-selective drugs has proven challenging, mainly due to the high conservation of the acetylcholine binding site among muscarinic receptor subtypes. Therefore, less conserved and topographically distinct allosteric binding sites have been explored to increase M1 receptor selectivity. In this line, bitopic ligands, which target orthosteric and allosteric binding ...
Tópico(s): Computational Drug Discovery Methods
2020 - American Chemical Society | ACS Omega
Produção Nacional
Revisado por pares
Giandra Volpato, Eliane M.Z. Michielin, Sandra Regina Salvador Ferreira, José Carlos Cunha Petrus,
The objective of this study was to investigate the effects of the parameters involved in the processing of de-boned chicken breast, with a view to reducing weight loss during cooking. The following were examined: the effect of chicken breast maturation time (0 and 24 h), the quantity of brine used in the curing (12% and 15% in relation to the raw material) and the curing time (2 and 7 h). The data were analyzed with the software Statistica version 6.0. The surface response method was also used in the ...
Tópico(s): Animal Nutrition and Physiology
2007 - Elsevier BV | Journal of Food Engineering
Produção Nacional
Revisado por pares
Denise Schmidt, Braulio Otomar Caron, Nadia Regina Volpato Menegat, Elvis Felipe Elli, John Robert Stolzle, Felipe Schwerz, Élder Eloy, Jaqueline Sgarbossa, Daiane Prochnow,
Shading greenhouse may be an effective method to achieve a suitable environment for crop growth in subtropical regions.The aim of this study was to evaluate the production of leaves and branches as well as the morphological parameters of height and leaf area of the species Aloysia triphylla, under different shading levels throughout the seasons of the year.A randomized block design in factorial scheme 3x4x6, i.e., three levels of shading (0%, 30% and 50%), four seasons (summer, autumn, winter and ...
Tópico(s): Greenhouse Technology and Climate Control
2017 - Southern Cross Publishing | Australian Journal of Crop Science
Regina Messerer, Michael Kauk, Daniela Volpato, Maria Consuelo Alonso Cañizal, Jessika Klöckner, Ulrike Zabel, Susanne Nuber, Carsten Hoffmann, Ulrike Holzgrabe,
Aiming to design partial agonists as well as allosteric modulators for the M1 muscarinic acetylcholine (M1AChR) receptor, two different series of bipharmacophoric ligands and their structural analogues were designed and synthesized. The hybrids were composed of the benzyl quinolone carboxylic acid (BQCA)-derived subtype selective allosteric modulator 3 and the orthosteric building block 4-((4,5-dihydroisoxazol-3-yl)oxy)-N,N-dimethylbut-2-yn-1-amine (base of iperoxo) 1 or the endogenous ligand 2-(dimethylamino) ...
Tópico(s): Neuroscience and Neuropharmacology Research
2017 - American Chemical Society | ACS Chemical Biology
Produção Nacional
Revisado por pares
Constanza Deyanu Alvear Pérez, Luciana de Barros Cavalcanti Michelutti, Maria Volpato Palharini, Luisa Pasqualotto Teixeira, Valéria Regina Silva, Lucas Emmanuel Pedro de Paiva Teixeira, Sílvia Lanziotti Azevedo da Silva, Simone Botelho,
Our objective was to investigate whether there is an interaction between the COVID-19 pandemic, demographic characteristics and erectile/sexual (E/S) function in individuals from Latin America.Cross-sectional study which included Latin American individuals over 18 years old, recruited through social media and interviewed between July and August 2020 by online surveys (Google Forms) in Portuguese and Spanish languages. The E/S function was evaluated through the following questionnaires: Simplified ...
Tópico(s): Body Image and Dysmorphia Studies
2022 - Sociedade Brasileira de Urologia | International braz j urol
Produção Nacional
Revisado por pares
Karine Cunha Volpato, Danusa Menegaz, Laura D. Leite, Kátia Padilha Barreto, Euler de Vilhena Garcia, Fátima Regina Mena Barreto Silva,
The purpose of this study was to investigate the involvement of calcium in K+ currents and its effects on amino acid accumulation and on the membrane potential regulated by tri-iodo-L-thyronine (T3) in Sertoli cells. Immature rat testes were pre-incubated for 30 min in Krebs-Ringer bicarbonate buffer and incubated for 60 min in the presence of [14C]methylaminoisobutyric acid with and without T3 or T4 (dose-response curve). Specific channel blockers or chelating agents were added at different concentrations ...
Tópico(s): Pharmacological Effects and Toxicity Studies
2003 - Elsevier BV | Life Sciences
Produção Nacional
Revisado por pares
Angélica Martins de Souza Gonçalves, Sandra Cristina Pillon, Rosa Jacinto Volpato, Sônia Regina Zerbetto, Fernando José Guedes da Silva Júnior,
ABSTRACT Objectives: to evaluate the impact of training on brief interventions for use of substances on the attitudes; and, face validity and internal consistency of Brazilian versions of the Drug and Drug Problems Perceptions Questionnaire (DDPPQ-br) and the Short Alcohol and Alcohol Problems Perception Questionnaire (SAAPPQ) for use among teachers. Methods: methodological (N=122) and quasi-experimental study (n=27). A sociodemographic questionnaire, the DDPPQ-br and the SAAPPQ were applied before ...
Tópico(s): Substance Abuse Treatment and Outcomes
2020 - Associação Brasileira de Enfermagem | Revista Brasileira de Enfermagem
Produção Nacional
Revisado por pares
José Carlos Saraiva Gonçalves, Tânia Monteiro, Claúdia Silvana de Miranda Neves, Karla Regina da Silva Gram, Nádia Maria Volpato, Vivian A Silva, Ricardo Carvalho Caminha, Maria do Rocio Bencke Gonçalves, Fábio Monteiro dos Santos, Gabriel Estolano da Silveira, François Noël,
A validated method for on-line solid-phase extraction coupled with high-performance liquid chromatography tandem mass spectrometry (SPE-HPLC-MS-MS) is described for the quantification of bromazepam in human plasma. The method involves a dilution of 300 muL of plasma with 100 muL of carbamazepine (2.5 ng/mL), used as internal standard, vortex-mixing, centrifugation, and injection of 100 muL of the supernate. The analytes were ionized using positive electrospray mass spectrometry then detected by multiple ...
Tópico(s): Analytical Chemistry and Chromatography
2005 - Lippincott Williams & Wilkins | Therapeutic Drug Monitoring
Produção Nacional
Revisado por pares
Regina Célia Rocha Peres, Luciane Cristina Coppi, Maria Cristina Volpato, Francisco Carlos Groppo, Jaime Aparecido Cury, Pedro Luiz Rosalen,
The aim of the present study was to evaluate the cariogenicity of cows', human and infant formula milks, supplemented or not with fluoride, in rats. Sixty female Wistar rats were desalivated and infected with Streptococcus sobrinus 6715.Animals were divided into six groups: group 1, sterilised deionised distilled water (SDW; negative control); group 2, 5 % sucrose added to SDW (positive control); group 3, human milk; group 4, cows' milk; group 5, Ninho ® formula reconstituted with SDW; group 6, Ninho ® ...
Tópico(s): Oral microbiology and periodontitis research
2008 - Cambridge University Press | British Journal Of Nutrition
Produção Nacional
Revisado por pares
Regina Lengruber da Silva, Nádia Maria Volpato,
A nimesulida é um antiinflamatório não-esteróide com baixa solubilidade em água e caráter fracamente ácido. O desenvolvimento dos ensaios de dissolução para fármacos de baixa hidrossolubilidade pode ser problemático e tensoativos são freqüentemente requeridos para aumentar a solubilização dos mesmos. No presente trabalho avaliou-se o efeito dos tensoativos lauril sulfato de sódio e polissorbato 80, na promoção da solubilidade da nimesulida em meio aquoso, determinando-se também o pH, a tensão superficial ...
Tópico(s): Analytical Methods in Pharmaceuticals
2002 - Sociedade Brasileira de Ciência do Solo | Revista Brasileira de Ciência do Solo
Produção Nacional
Revisado por pares
Gildo Volpato, Édina Regina Baumer, Jéferson Luiz de Azeredo, Lucas Dominguini,
O objetivo do estudo foi compreender os motivos pela escolha da licenciatura, o processo de formacao e suas percepcoes sobre a funcao do professor na sociedade atual. Trata-se de uma pesquisa qualitativa desenvolvida de forma coletiva. Foram realizadas entrevistas do tipo semi-estruturada com 05 alunos do Curso de Artes Visuais e 05 alunos do Curso de Matematica da Universidade do Extremo Sul Catarinense, UNESC, Criciuma, SC. O estudo demonstrou que a escolha do curso se deu pela identificacao com ...
Tópico(s): Science and Education Research
2011 - UNIVERSIDADE FEDERAL DE VIÇOSA | Educação em Perspectiva
Produção Nacional
Revisado por pares
Pâmela Migliorini Claudino da Silva, Tanyse Galon, Adaene Alves Machado de Moura, Rosa Jacinto Volpato, Sônia Regina Zerbetto, Angélica Martins de Souza Gonçalves,
Objetivo: elaborar uma capacitação sobre uso de substâncias psicoativas destinada a professores de ensino médio e fundamental e submetê-lo à avaliação por especialistas. Método: foi realizado um estudo metodológico e qualitativo. A trajetória metodológica seguiu as etapas: desenvolvimento de aulas da capacitação, envio do material para análise das especialistas e avaliação das questões. Resultados: foram avaliados 11 itens do questionário avaliativo de conformidade, e apenas dois deles não apresentaram ...
Tópico(s): Science and Education Research
2019 - UNIVERSIDADE DO ESTADO DE MATO GROSSO | Journal Health NPEPS
Produção Nacional
Revisado por pares
Regina Célia Rocha Peres, Luciane Cristina Coppi, Eliane Melo Franco, Maria Cristina Volpato, Francisco Carlos Groppo, Pedro Luiz Rosalen,
This study evaluated the cariogenic potential of infant formulas and cow’s milk, using a high cariogenic challenge in the anima l model. Sixty female Wistar rats infected with Streptococcus sobrinus and desalivated were randomly divided into 6 groups, which received ad libitum: 1) sterilized deionized distilled water (SDW) with 5% sucrose; 2) cow’s milk; 3) Nan 2 ® ; 4) Nestogeno 2 ® ; 5) Ninho ® growth supporting; 6) SDW. Groups 1 and 6 also received essential diet NCP#2 by gavage, twice a day. After 21 days, ...
Tópico(s): Bone and Dental Protein Studies
2002 - Institute of Electrical and Electronics Engineers | Scopus
Produção Nacional
Revisado por pares
Sonia Regina Hierro Parolin, Eduardo Pinheiro Gondim de Vasconcellos, Maricilia Volpato, Alisson Marcelo Laurindo,
Discussions about innovation tend to a more systemic and cooperative approach in which those networks focused on scientific and technological development are considered.This article aims to identify the barriers and facilitators in the collaborative management process of technological innovation projects and a study has been carried out by the cooperation action for innovation with 17 industries in Brazil.The primary evidence refers to the crucial role of project managers when leading the structural ...
Tópico(s): Business and Management Studies
2013 - Alberto Hurtado University | Journal of technology management & innovation
Produção Nacional
Revisado por pares
Marluci Betini, Enilze de Souza Nogueira Volpato, Guilherme D. J. Anastácio, Renata T. B. G. de Faria, Regina El Dib,
Abstract Rationale, aims and objectives The importance of systematic reviews ( SRs ) as an aid to decision making in health care has led to an increasing interest in the development of this type of study. When selecting a target journal for publication, authors generally seek out higher impact factor journals. This study aimed to determine the percentage of scientific medical journals that publish SRs according to their impact factors (>2.63) and to determine whether those journals require tools that ...
Tópico(s): Health Systems, Economic Evaluations, Quality of Life
2014 - Wiley | Journal of Evaluation in Clinical Practice
Niccolò E. Mencacci, Regina H. Reynolds, Sonia García-Ruiz, Jana Vandrovcová, Paola Forabosco, Álvaro Sánchez‐Ferrer, Viola Volpato, Juan A. Botía, Karishma D’Sa, Paola Forabosco, Sebastian Guelfi, John Hardy, Jana Vandrovcová, C. L. MacKenzie, Adaikalavan Ramasamy, Mina Ryten, Colin Smith, Daniah Trabzuni, Michael E. Weale, Alastair Noyce, Rauan Kaiyrzhanov, Ben Middlehurst, Demis A. Kia, Manuela Tan, Henry Houlden, Huw R. Morris, Hélène Plun‐Favreau, Peter Holmans, John Hardy, Daniah Trabzuni, José Brás, John P. Quinn, Kin Y. Mok, Kerri J. Kinghorn, Kimberley Billingsley, Nicholas Wood, Patrick A. Lewis, Rita Guerreiro, Ruth C. Lovering, Lea R’Bibo, Claudia Manzoni, Mie Rizig, Mina Ryten, Sebastian Guelfi, Valentina Escott‐Price, Viorica Chelban, Thomas Foltynie, Nigel Williams, Chingiz Shashakin, Nazira Zharkinbekova, Elena Zholdybayeva, Akbota Aitkulova, Kirsten Harvey, Michael E. Weale, Kailash P. Bhatia, Caleb Webber, John Hardy, Juan A. Botía, Mina Ryten,
Abstract Dystonia is a neurological disorder characterized by sustained or intermittent muscle contractions causing abnormal movements and postures, often occurring in absence of any structural brain abnormality. Psychiatric comorbidities, including anxiety, depression, obsessive-compulsive disorder and schizophrenia, are frequent in patients with dystonia. While mutations in a fast-growing number of genes have been linked to Mendelian forms of dystonia, the cellular, anatomical, and molecular basis ...
Tópico(s): Parkinson's Disease Mechanisms and Treatments
2020 - Oxford University Press | Brain
Produção Nacional
Gustavo Tadeu Volpato, Débora Cristina Damasceno, Márcia Regina F. Miranda, Daher Sabbag Filho, Iracema de Mattos Paranhos Calderon, Marilza Vieira Cunha Rudge,
To evaluate the reproductive performance and the development of their offspring on rat pregnancy, Wistar pregnant rats were gavaged with 0 mg/kg wb/day (control group, n = 20) and 166.5 mg/kg/day of a mixture of vitamin C, hesperidin and piperidol (experimental group, n= 20) during the organogenic period (from day 5 to 14 of pregnancy; positive vaginal smear = day 0). The female rats were killed on day 21 of pregnancy. The number of implantations, resorptions (dead embryos), and live/dead fetuses were counted ...
Tópico(s): Pregnancy and Medication Impact
2006 - UNIVERSIDADE DE SÃO PAULO | Revista Brasileira de Ciências Farmacêuticas
Produção Nacional
Revisado por pares
Enilze de Souza Nogueira Volpato, Marluci Betini, Maria Eduarda dos Santos Puga, Arnav Agarwal, Antônio José Maria Catâneo, Luciane Dias de Oliveira, Rodrigo Bazán, Leandro Gobbo Braz, José Eduardo Guimarães Pereira, Regina El Dib,
BACKGROUND: A high-quality electronic search is essential for ensuring accuracy and comprehensiveness among the records retrieved when conducting systematic reviews. Therefore, we aimed to identify the most efficient method for searching in both MEDLINE (through PubMed) and EMBASE, covering search terms with variant spellings, direct and indirect orders, and associations with MeSH and EMTREE terms (or lack thereof). DESIGN AND SETTING: Experimental study. UNESP, Brazil. METHODS: We selected and analyzed ...
Tópico(s): Academic Writing and Publishing
2018 - Medical Association of São Paulo | Sao Paulo Medical Journal
Luciana de Barros Cavalcanti Michelutti, Constanza Deyanu Alvear Pérez, Luísa Teixeira Pasqualotto, Maria P. Volpato, Valéria Regina Silva, Lucas Emmanuel Pedro de Paiva Teixeira, Simone Botelho,
Tópico(s): Adolescent Sexual and Reproductive Health
2025 - Editora Rede UNIDA | CADERNOS DE EDUCAÇÃO SAÚDE E FISIOTERAPIA
Gildo Volpato, Édina Regina Baumer, Jéferson Luís de Azeredo, Lucas Dominguini,
O objetivo da pesquisa foi compreender os motivos que levaram os alunos escolherem um curso de licenciatura e como avaliam sua formacao. Tambem compreender as percepcoes sobre a funcao do professor na sociedade atual e as perspectivas de futuro no âmbito dessa profissao. Foi uma construcao coletiva desenvolvida na disciplina “Teorias Contemporâneas sobre formacao de professores” no Mestrado em Educacao da Universidade do Extremo Sul Catarinense, UNESC, Criciuma, Santa Catarina. Foram entrevistados ...
Tópico(s): Science and Education Research
2009 - UNIVERSIDADE DE SÃO PAULO | Revista da Faculdade de Educação