Annefleur C. Langedijk, Cornelis A. De Pijper, René Spijker, Rebecca Holman, Martin P. Grobusch, Cornelis Stijnis,
Although fatal once symptomatic, rabies is preventable by administration of pre- and post-exposure vaccines. International guidelines suggest lifelong protection by a pre-exposure vaccination scheme followed by timely post-exposure vaccines. Rapidity and magnitude of the antibody recall response after booster inoculation are essential, as many people have been previously immunized a long time ago. The objective of this study was therefore to systematically review the evidence on the boostability ...
Tópico(s): Virology and Viral Diseases
2018 - Oxford University Press | Clinical Infectious Diseases
Christianus M. A. Leenders, Matthew B. Baker, Imke A. B. Pijpers, René P. M. Lafleur, Lorenzo Albertazzi, Anja R. A. Palmans, E. W. Meijer,
The self-assembly of a family of benzene-1,3,5-tricarboxamides (BTAs) in water is studied systematically to elucidate the role of hydrophobic and hydrogen-bond interactions.
Tópico(s): Crystallography and molecular interactions
2016 - Royal Society of Chemistry | Soft Matter
Mascha van ‘t Wout‐Frank, Annemiek van Dijke, André Alemán, R.P.C. Kessels, Wietske Pijpers, René S. Kahn,
Although schizophrenia has often been associated with deficits in facial affect recognition, it is debated whether the recognition of specific emotions is affected and if these facial affect-processing deficits are related to symptomatology or other patient characteristics. The purpose of the present study was to explore whether particular patient characteristics are associated with the recognition of specific facial expressions in patients with schizophrenia. Sixty-four patients with a DSM-IV diagnosis ...
Tópico(s): Anxiety, Depression, Psychometrics, Treatment, Cognitive Processes
2007 - Lippincott Williams & Wilkins | The Journal of Nervous and Mental Disease
Jannic A.A. van Leendert, Aimée E. M. J. H. Linkens, Martijn Poeze, Evelien Pijpers, Fabienne Magdelijns, René H.M. ten Broeke, Bart Spaetgens,
Hip fractures are a major cause of mortality and disability in frail older adults. Therefore, orthogeriatrics has been embraced to improve patient outcomes. With the optimal template of orthogeriatric care still unknown, and to curtail rising healthcare expenditure we implemented a nurse practitioner-led orthogeriatric care program (NPOCP). The objective was to evaluate NPOCP by measuring 3-month and 1-year mortality, compared to usual care (UC). In addition, length of stay (LOS) and location of hospital ...
Tópico(s): Emergency and Acute Care Studies
2021 - Oxford University Press | Age and Ageing
René H.M. Verheijen, Rik Pijpers, Paul J. van Diest, Curt W. Burger, Marrije R. Buist, Peter Kenemans,
In Brief Background For superficial tumors such as melanoma, breast, and vulvar cancer, sentinel node detection prevents unnecessary extensive lymph node dissections. Sentinel node detection has not yet proved feasible in tumors, such as cervical cancer, that drain to deep pelvic lymph nodes. Technique We injected technetium-99m colloidal albumin around the tumor allowing preoperative lymphscintigraphy and intraoperative gamma probe detection of sentinel nodes. For visual detection, blue dye was ...
Tópico(s): Cutaneous Melanoma Detection and Management
2000 - Lippincott Williams & Wilkins | Obstetrics and Gynecology
Rasmus Blaaholm Nielsen, Bjarke Strøm Larsen, René Holm, Ils Pijpers, Jan Snoeys, Ulla Gro Nielsen, Ingunn Tho, Carsten Uhd Nielsen,
P-glycoprotein (P-gp) inhibitors, like zosuquidar, partly increase oral bioavailability of P-gp substrates, such as etoposide. Here, it was hypothesised that co-release of etoposide and zosuquidar from amorphous solid dispersions (ASDs) may further increase oral etoposide bioavailability. This was envisioned through simultaneous co-release and subsequent spatiotemporal association of etoposide and zosuquidar in the small intestinal lumen. To further achieve this, ASDs of etoposide and zosuquidar in ...
Tópico(s): Advanced Drug Delivery Systems
2023 - Elsevier BV | International Journal of Pharmaceutics
Eline J. C. Nieuwenhuis, I. van der Waal, C. René Leemans, Alain Kümmer, Rik Pijpers, Jonas A. Castelijns, Ruud H. Brakenhoff, Gordon B. Snow,
Background. In patients with head and neck squamous cell carcinoma (HNSCC), the presence of lymph node metastases is the most important prognosticator. Sentinel node (SN) biopsy has been shown to be an accurate staging technique for patients with breast cancer and melanoma and might also be suited for patients with HNSCC. This study was undertaken to determine whether the SN concept holds true for HNSCC and could be exploited for SN biopsy. Methods. In 22 patients with T2 to T4 N0 oral or oropharyngeal ...
Tópico(s): Ear and Head Tumors
2004 - Wiley | Head & Neck
Marrije R. Buist, Rik Pijpers, Arthur van Lingen, Paul J. van Diest, Jan Dijkstra, Peter Kenemans, René H.M. Verheijen,
The purpose of this study was to investigate the feasibility of sentinel node detection through laparoscopy in patients with early cervical cancer. Furthermore, the results of laparoscopic pelvic lymph node dissection were studied, validated by subsequent laparotomy.Twenty-five patients with early stage cervical cancer who planned to undergo a radical hysterectomy and pelvic lymph node dissection received an intracervical injection of technetium-99m colloidal albumin as well as blue dye. With a ...
Tópico(s): Ovarian cancer diagnosis and treatment
2003 - Elsevier BV | Gynecologic Oncology
Rasmus Blaaholm Nielsen, René Holm, Ils Pijpers, Jan Snoeys, Ulla Gro Nielsen, Carsten Uhd Nielsen,
P-glycoprotein inhibitors, like zosuquidar, have widely been used to study the role of P-glycoprotein in oral absorption. Still, systematic studies on the inhibitor dose-response relationship on intestinal drug permeation are lacking. In the present study, we investigated the effect of 0.79 nM-2.5 μM zosuquidar on etoposide permeability across Caco-2 cell monolayers. We also investigated etoposide pharmacokinetics after oral or IV administration to Sprague Dawley rats with co-administration of 0. ...
Tópico(s): Pharmacological Effects and Toxicity Studies
2021 - Elsevier BV | International Journal of Pharmaceutics X
Eline J. C. Nieuwenhuis, Jonas A. Castelijns, Rik Pijpers, Michiel W. M. van den Brekel, Ruud H. Brakenhoff, I. van der Waal, Gordon B. Snow, C. René Leemans,
Management of the N0 neck in patients with head and neck squamous cell carcinoma (SCC) remains controversial. We describe the outcome of patients who underwent transoral tumor excision and a wait-and-see policy for the neck staged N0 by ultrasonography-guided cytology (USgFNAC). Because selection of lymph nodes for USgFNAC is currently based on size criteria, we investigated the additional value of sentinel node (SN) identification.The outcome of 161 patients with T1-T2 oral/oropharyngeal SCC was determined. ...
Tópico(s): Colorectal and Anal Carcinomas
2002 - Wiley | Head & Neck
Rik Pijpers, Marrije R. Buist, Arthur van Lingen, Jan Dijkstra, P. J. van Diest, G. J. J. Teule, Peter Kenemans, René H.M. Verheijen,
Tópico(s): Sarcoma Diagnosis and Treatment
2004 - Springer Science+Business Media | European Journal of Nuclear Medicine and Molecular Imaging
René Koopman, Lex B. Verdijk, Ralph Manders, Annemie P. Gijsen, M. Gorselink, Evelien Pijpers, Anton J. M. Wagenmakers, Luc J. C. van Loon,
Background: The progressive loss of skeletal muscle mass with aging is attributed to a disruption in the regulation of skeletal muscle protein turnover. Objective: We investigated the effects on whole-body protein balance and mixed-muscle protein synthesis rates of the ingestion of carbohydrate with or without protein and free leucine after simulated activities of daily living. Design: Eight elderly (75 ± 1 y) and 8 young (20 ± 1 y) lean men were randomly assigned to 2 crossover experiments in which they ...
Tópico(s): Sports Performance and Training
2006 - Elsevier BV | American Journal of Clinical Nutrition
Ahmed A. Abdulhussein Al-Ali, Louis Sandra, Dries Versweyveld, Ils Pijpers, Lieve Dillen, An Vermeulen, Jan Snoeys, René Holm, Carsten Uhd Nielsen,
It has been suggested that oral absorption of low-permeable P-glycoprotein (P-gp) substrates can be increased through saturation of P-gp. For BCS class IV drug substances, saturating P-gp is challenging due to low aqueous solubility. The present study investigated if the BCS IV drug substance etoposide could be solubilized to a concentration saturating P-gp after oral administration. A formulation consisting of 10% (w/v) of pluronic® F-127 and polyvinylpyrrolidone/vinyl acetate (PVP/VA), and 57% (v/ ...
Tópico(s): Antibiotics Pharmacokinetics and Efficacy
2020 - Elsevier BV | International Journal of Pharmaceutics
Emilie Fynbo Petersen, Bjarke Strøm Larsen, Rasmus Blaaholm Nielsen, Ils Pijpers, Dries Versweyveld, René Holm, Ingunn Tho, Jan Snoeys, Carsten Uhd Nielsen,
The oral bioavailability of paclitaxel is limited due to low solubility and high affinity for the P-glycoprotein (P-gp) efflux transporter. Here we hypothesized that maximizing the intestinal paclitaxel levels through apparent solubility enhancement and controlling the simultaneous release of both paclitaxel and the P-gp inhibitor encequidar from amorphous solid dispersions (ASDs) would increase the oral bioavailability of paclitaxel. ASDs of paclitaxel and encequidar in polyvinylpyrrolidone K30 (PVP- ...
Tópico(s): Drug Solubulity and Delivery Systems
2024 - Elsevier BV | International Journal of Pharmaceutics
Gerrit L.J. Onderwater, Lannie Ligthart, Mariska Bot, Ayşe Demirkan, Jingyuan Fu, Carla Kallen, Lisanne S. Vijfhuizen, René Pool, Jun Liu, Floris Vanmolkot, Marian Beekman, Kexin Wen, Najaf Amin, Carisha S. Thesing, Judith A. Pijpers, Dennis A. Kies, Ronald Zielman, Irene de Boer, Marleen M. J. van Greevenbroek, Ilja C.W. Arts, Yuri Milaneschi, Miranda T. Schram, Pieter C. Dagnelie, Lude Franke, M. Arfan Ikram, Michel D. Ferrari, Jelle J. Goeman, P. Eline Slagboom, Cisca Wijmenga, Coen D.A. Stehouwer, Dorret I. Boomsma, Cornelia M. van Duijn, Brenda W.J.H. Penninx, Peter A.C. ‘t Hoen, Gisela M. Terwindt, Arn M. J. M. van den Maagdenberg,
Objective To identify a plasma metabolomic biomarker signature for migraine. Methods Plasma samples from 8 Dutch cohorts (n = 10,153: 2,800 migraine patients and 7,353 controls) were profiled on a 1 H-NMR-based metabolomics platform, to quantify 146 individual metabolites (e.g., lipids, fatty acids, and lipoproteins) and 79 metabolite ratios. Metabolite measures associated with migraine were obtained after single-metabolite logistic regression combined with a random-effects meta-analysis performed in a nonstratified ...
Tópico(s): Neuroscience of respiration and sleep
2019 - Lippincott Williams & Wilkins | Neurology
Fabienne Magdelijns, Evelien Pijpers, Rob P.W. Rouhl, Pascal F. W. Hannemann, René H.M. ten Broeke, J. Dings, Coen D.A. Stehouwer, Patricia M. Stassen,
Health care-related adverse events (HCRAEs), which should not be confused with (blameworthy) medical errors, are common; they can lead to hospital admissions and can have grave consequences. Although they are sometimes potentially preventable, information is lacking on HCRAEs leading to admission to different departments.This study aimed to gain insight into the incidence, type, severity, and preventability of HCRAEs (including adverse drug events) leading to hospitalization to the departments of internal ...
Tópico(s): Healthcare Decision-Making and Restraints
2015 - Elsevier BV | Journal of the American Medical Directors Association
Rasmus Blaaholm Nielsen, René Holm, Ils Pijpers, Jan Snoeys, Ulla Gro Nielsen, Carsten Uhd Nielsen,
P-glycoprotein (P-gp) limits the oral absorption of drug substances. Potent small molecule P-gp inhibitors (e.g., zosuquidar) and nonionic surfactants (e.g., polysorbate 20) inhibit P-gp by proposedly different mechanisms. Therefore, it was hypothesised that a combination of zosuquidar and polysorbate 20 may potentiate inhibition of P-gp-mediated efflux. P-gp inhibition by zosuquidar and polysorbate 20 in combination was assessed in a calcein-AM assay and in a transcellular etoposide permeability study ...
Tópico(s): Antibiotics Pharmacokinetics and Efficacy
2023 - Multidisciplinary Digital Publishing Institute | Pharmaceutics
... the emergence of the cluster (Maas Citation2011). Roos Pijpers further elaborated the theoretical framework by connecting to ... the cluster and to refresh the empirical material. Pijpers and Maas have different, albeit complementary, reasons for ... Luibhéid Citation2008a, 172).Additional informationNotes on contributorsRoos PijpersRoos Pijpers studied Economics at Tilburg University, the Netherlands. She ...
Tópico(s): Migration and Labor Dynamics
2013 - Taylor & Francis | Gender Place & Culture