Robin W. Jansen, Christiaan M. de Bloeme, Liesbeth Cardoen, Sophia Göricke, Sabien van Elst, Jaime Jessen, Aparna Ramasubramanian, Alison H. Skalet, Audra K. Miller, Philippe Maeder, Ogul E. Uner, G. Baker Hubbard, Hans E. Grossniklaus, H. Culver Boldt, Kim E. Nichols, Rachel C. Brennan, Saugata Sen, Selma Sirin, Hervé J. Brisse, Paolo Galluzzi, Charlotte J. Dommering, Jonas A. Castelijns, Paul van der Valk, Ronald Boellaard, Josephine C. Dorsman, Annette C. Moll, Marcus C. de Jong, Pim de Graaf,
Background MYCN-amplified RB1 wild-type (MYCNARB1+/+) retinoblastoma is a rare but clinically important subtype of retinoblastoma due to its aggressive character and relative resistance to typical therapeutic approaches. Because biopsy is not indicated in retinoblastoma, specific MRI features might be valuable to identify ... Purpose To define the MRI phenotype of MYCNARB1+/+ retinoblastoma and evaluate the ability of qualitative MRI features ... control study, MRI scans in children with MYCNARB1+/+ retinoblastoma and age-matched children with RB1−/− subtype retinoblastoma ...
Tópico(s): Ear and Head Tumors
2023 - Radiological Society of North America | Radiology
Yingxiu Luo, Mengjia He, Jie Yang, Feifei Zhang, Jie Chen, Xuyang Wen, Jiayan Fan, Xianqun Fan, Peiwei Chai, Renbing Jia,
Retinoblastoma, the most prevalent primary intraocular tumor in children, leads to vision impairment, disability and even death. ... been documented as another common oncogenic alteration in retinoblastoma and represents one of the high-risk molecular subtypes of retinoblastoma. However, how MYCN contributes to the progression of retinoblastoma is still incompletely understood. Here, we report that ... proteins for N6-methyladenosine (m6A) RNA modification, in retinoblastoma. We further found that this MYCN-upregulated m6A ...
Tópico(s): Cancer-related molecular mechanisms research
2023 - Springer Science+Business Media | Science China Life Sciences
Ruiheng Zhang, Li Dong, Ruyue Li, Kai Zhang, Yitong Li, Hong-shu Zhao, Jitong Shi, Xin Ge, Xiaolin Xu, Libin Jiang, Xu‐Han Shi, Chuan Zhang, Wen‐Da Zhou, Liangyuan Xu, Haotian Wu, Heyan Li, Chuyao Yu, Jing Li, Jianmin Ma, Wenbin Wei,
Retinoblastoma is the most common intraocular malignancy in childhood. With the advanced management strategy, the globe salvage ... up and offspring screening. This cohort study includes retinoblastoma patients who visited Beijing Tongren Hospital from March ... deep learning algorism development. Clinical-suspected and treated retinoblastoma patients from February 2022 to June 2022 were ... algorithm was trained to identify "normal fundus", "stable retinoblastoma" in which specific treatment is not required, and " ...
Tópico(s): Retinal Diseases and Treatments
2023 - Springer Nature | British Journal of Cancer
Shiraya Thompson, Beate Ritz, Myles Cockburn, Julia E. Heck,
Retinoblastoma is a rare tumor of the retina, most commonly found in young children. Due to the ... risk factor. To examine the relationship between childhood retinoblastoma and prenatal exposure to pesticides through residential proximity ... by age resulted in 221 cases of unilateral retinoblastoma and 114 cases of bilateral retinoblastoma, totaling 335 cases and 123,166 controls. Based ... residence reported on birth certificates. The associations between retinoblastoma (all types combined and stratified by laterality) and ...
Tópico(s): Childhood Cancer Survivors' Quality of Life
2022 - Elsevier BV | International Journal of Hygiene and Environmental Health
Retinoblastoma, often referred to as eye cancer, is a common primary pediatric intraocular malignancy. In this framework, ... ribose nucleic acids (miRNAs) play essential roles in retinoblastoma oncogenesis and development. However, the function and mechanism ... sushi domain-containing protein 2 (SUSD2) axis in retinoblastoma are unclear. To address these issues, miR-141-3p and SUSD2 expressions between the retinoblastoma patients and the normal control are identified by ... of the miR-141-3p/SUSD2 axis in retinoblastoma oncogenesis and development. Our data showed that SUSD2 ...
Tópico(s): Cancer-related Molecular Pathways
2022 - Taylor & Francis | Bioengineered
Paul T. Finger, Ankit Singh Tomar,
Retinoblastoma is the most common paediatric eye cancer, and is typically curable through early diagnosis and protocol- ... for American Joint Committee on Cancer staging of retinoblastoma: part I: metastasis-associated mortality.Ophthalmology. 2020; 127: ... for American Joint Committee on Cancer staging of retinoblastoma: part II: treatment success and globe salvage.Ophthalmology. ... ID Abdallah E Abdullahi SU et al.Global retinoblastoma presentation and analysis by national income level.JAMA ... AS Finger PT Gallie B et al.Global retinoblastoma treatment outcomes: association with national income level.Ophthalmology. ...
Tópico(s): Cancer Genomics and Diagnostics
2022 - Elsevier BV | The Lancet Global Health
Hua Jiang, Chuanqiang Niu, Yiqun Guo, Zhenyin Liu, Yi‐Zhou Jiang,
Retinoblastoma is a most frequently occurring primary intraocular tumor in infancy and children, highlighting the requirement to ... various signaling pathways; however, its potential influences on retinoblastoma progression are still unknown, and thus was investigated ... that WDL treatments significantly reduced the proliferation of retinoblastoma cells by inducing apoptosis and pyroptosis through increasing ... generation were considerably up-regulated in WDL-incubated retinoblastoma cells through a dose-dependent manner. Notably, we ...
Tópico(s): Toxoplasma gondii Research Studies
2022 - Elsevier BV | International Immunopharmacology
Carol L. Shields, Zeynep Baş, Andrea Laiton, Ana Maria Velasco Silva, Ahmed Sheikh, Sara E. Lally, Jerry A. Shields,
... this review we discuss several recent concepts regarding retinoblastoma control and its impact. In a cohort of 482 patients with solitary unilateral retinoblastoma revealed germline mutation in 16% and the likelihood of germline retinoblastoma was greater for younger children (≤1 year versus ( ... 0.002). Retinocytoma/retinoma, a benign variant of retinoblastoma, was studied in 78 tumours and demonstrated transformation into retinoblastoma in 9.2% by 5 years and 15. ... and 20 years. An international global study on retinoblastoma over 1.5 years revealed 4351 new patients ...
Tópico(s): Nonmelanoma Skin Cancer Studies
2022 - Springer Nature | Eye
Robin W. Jansen, Sophie van der Heide, Liesbeth Cardoen, Selma Sirin, Christiaan M. de Bloeme, Paolo Galluzzi, Sophia Göricke, Hervé J. Brisse, Philippe Maeder, Saugata Sen, Eva Biewald, Jonas A. Castelijns, Annette C. Moll, Paul van der Valk, Marcus C. de Jong, Pim de Graaf, Pim de Graaf, Marcus C. de Jong, Robin W. Jansen, Christiaan M. de Bloeme, Jonas A. Castelijns, Hervé J. Brisse, Liesbeth Cardoen, Sophia Göricke, Selma Sirin, Paolo Galluzzi, Philippe Maeder,
... prevalence and magnetic resonance imaging (MRI) phenotype of retinoblastoma-associated orbital cellulitis. Additionally, this study aimed to ... prevalence of orbital cellulitis features on MRI in retinoblastoma patients. A multicenter case-control study compared MRI features of the retinoblastoma-associated orbital cellulitis cases with retinoblastoma controls.A consecutive retinoblastoma patient cohort of 236 patients (311 eyes) was retrospectively investigated. Subsequently, 30 retinoblastoma cases with orbital cellulitis were compared with 30 ...
Tópico(s): IgG4-Related and Inflammatory Diseases
2022 - Elsevier BV | Ophthalmology
Yingxiu Luo, Chuandi Zhou, Fanglin He, Jiayan Fan, Xuyang Wen, Yi Ding, Yanping Han, Jingwen Ding, Mei Jin, Zhenyin Liu, Sha Wang, Minglei Han, Hongfeng Yuan, Hong Sun, Yi-shuang Xiao, Wu Li, Jian-Cang Wang, Yangjun Li, Huasheng Yang, Jiawei Yu, Jianyang Gong, Yuxin Xu, Yuechun Wen, Ziqing Gao, Lixin Mei, Juan Ye, Hu Liu, Zhijun Chen, Shangcai Xue, Rong Liu, Hong Chen, Wei Lu, Hongfei Liao, Qing Guo, Jizhe Cui, Dan Zhu, Fang Lü, Song Tang, Yu Wu, Tseden Yangkyi, Guanghong Zhang, Miershalijiang Wubuli, Huiyu Guo, Xian Wang, Yanjin He, Xunlun Sheng, Qing Wang, Jia Tan, Jianhong Liang, Xiantao Sun, Jing Zhang, Xunda Ji, Liwen Jin, Junyang Zhao, Xinji Yang, Renbing Jia, Xianqun Fan,
... associated with mortality and enucleation in patients with retinoblastoma in China. DESIGN Retrospective cohort study. METHODS This multicenter study included 2552 patients diagnosed with retinoblastoma in 38 medical centers in 31 provinces in ... at a better stage by International Classification for Retinoblastoma over time (Kendall's tau-b value = –0. ... risk factors for eye salvage failure. Among intraocular retinoblastoma, Groups D and E had higher risk of ... associated with mortality and enucleation in patients with retinoblastoma in China. Retrospective cohort study. This multicenter study ...
Tópico(s): Nonmelanoma Skin Cancer Studies
2021 - Elsevier BV | American Journal of Ophthalmology
Jie Yang, Yongyun Li, Yanping Han, Yiyi Feng, Min Zhou, Chunyan Zong, Xiaoyu He, Renbing Jia, Xiaofang Xu, Jiayan Fan,
Abstract Retinoblastoma is a childhood retinal tumour that is the most common primary malignant intraocular tumour. However, it has ... RNA sequencing on 14,739 cells from two retinoblastoma samples to delineate the heterogeneity and the underlying mechanism of retinoblastoma progression. Using a multiresolution network-based analysis, we identified two major cell types in human retinoblastoma. Cell trajectory analysis yielded a total of 5 ... cone precursors were the cells of origin of retinoblastoma that were required for initiating the differentiation and ...
Tópico(s): interferon and immune responses
2021 - Springer Nature | Cell Death and Disease
David H. Abramson, Diana Mandelker, Jasmine H. Francis, Ira J. Dunkel, A. Rose Brannon, Ryma Benayed, Michael F. Berger, Maria E. Arcila, Marc Ladanyi, Danielle Novetsky Friedman, Gowtham Jayakumaran, Monica Diosdado, Melissa A. Robbins, Dianna Haggag-Lindgren, Neerav Shukla, Michael F. Walsh, Prachi Kothari, Dana W.Y. Tsui,
... DNA (ctDNA) in the plasma of patients with retinoblastoma and simulating lesions.DesignRetrospective cross-sectional study of the association of plasma ctDNA from retinoblastoma and simulating lesions with disease course.ParticipantsFifty-eight Memorial Sloan Kettering Cancer Center patients with retinoblastoma comprising 68 plasma ctDNA samples and 5 with retinoblastoma-simulating lesions.MethodsThe ctDNA analyzed with hybridization capture ... sequencing in blood (plasma) of patients who had retinoblastoma or simulating lesions were evaluated for association with ...
Tópico(s): Epigenetics and DNA Methylation
2021 - Elsevier BV | Ophthalmology Science
Kun Li, Fengmei Han, Yanping Wu, Xue Wang,
... of gene expression involved in tumor pathogenesis, including retinoblastoma. However, the expression profiles and potential roles in retinoblastoma are still largely unclear.Differentially expressed miRNAs (DEmiRs) and genes (DEGs) in retinoblastoma were extracted from Gene Expression Omnibus (GEO) repository. ... of miR-340 and WIF1 were detected in retinoblastoma tissues and cell lines by qRT-PCR. Both ... A total of 11 DEmiRs were identified in retinoblastoma tissue and blood samples. Among them, we validated ...
Tópico(s): Kruppel-like factors research
2021 - Dove Medical Press | OncoTargets and Therapy
Xiuming Liu, Xiaofeng Li, Jianchang Li,
Retinoblastoma is the most common malignancy in children's eyes with high incidence. Long non-coding RNAs (lncRNAs) play important roles in the progression of retinoblastoma. LncRNA FEZF1 antisense RNA 1 (FEZF1-AS1) has been found to stimulate retinoblastoma. However, the mechanism of FEZF1-AS1 underlying progression of retinoblastoma is still unclear. In current study, FEZF1-AS1 was up-regulated in retinoblastoma tissues and cells. FEZF1-AS1 overexpression enhanced retinoblastoma cell viability, promoted cell cycle, and inhibited apoptosis. ...
Tópico(s): Viral-associated cancers and disorders
2021 - Springer Science+Business Media | Biochemical Genetics
Produção Nacional
Revisado por pares
Swathi Kaliki, Carol L. Shields, Nathalie Cassoux, Francis L. Munier, Guillermo Chantada, Hans E. Grossniklaus, Hiroshi Yoshikawa, Ido Didi Fabian, Jesse L. Berry, John D. McKenzie, Kahaki Kimani, M. Ashwin Reddy, Manoj Parulekar, Mika Tanabe, Minoru Furuta, Natalia Grigorovski, Patricia Chévez‐Barrios, Patricia Scanlan, Ralph C. Eagle, Riffat Rashid, Rosdali Díaz Coronado, Sadia Sultana, Sandra E. Staffieri, Shahar Frenkel, Shigenobu Suzuki, Tatiana L. Ushakova, Xunda Ji,
High-risk histopathologic features of retinoblastoma are useful to assess the risk of systemic metastasis. In this era of globe salvage treatments for retinoblastoma, the definition of high-risk retinoblastoma is evolving.To evaluate variations in the definition of high-risk histopathologic features for metastasis of retinoblastoma in different ocular oncology practices around the world. ... December 2020 to 52 oncologists and pathologists treating retinoblastoma at referral retinoblastoma centers.Anonymized survey about the ...
Tópico(s): Ear and Head Tumors
2021 - American Medical Association | JAMA Ophthalmology
Sabine Dittner‐Moormann, Madlen Reschke, Floor Abbink, Isabelle Aerts, Hatice Tuba Atalay, Nadezhda Fedorovna Bobrova, Eva Biewald, Ines B. Brecht, Shani Caspi, Nathalie Cassoux, Guilherme Castela, Yelena Diarra, Catriona Duncan, Martin Ebinger, David García Aldana, Theodora Hadjistilianou, Tomáš Kepák, Artur Klett, Hayyam Kıratlı, Erika Maka, Enrico Opocher, Katarzyna Pawińska-Wąsikowska, Jelena Rascon, Ida Russo, Olga Rutynowska‐Pronicka, Constantino Sábado, Sonsoles San Román Pacheco, Karel Švojgr, Beate Timmermann, Vicktoria Vishnevskia‐Dai, Angelika Eggert, Petra Ritter‐Sovinz, Nikolaos E. Bechrakis, Helen Jenkinson, Annette C. Moll, Francis L. Munier, Maja Beck‐Popovic, Guillermo Chantada, François Doz, Petra Ketteler,
Abstract Introduction Advanced intraocular retinoblastoma can be cured by enucleation, but spread of retinoblastoma cells beyond the natural limits of the eye is related to ... metastasis in children with risk factors for extraocular retinoblastoma. However, histological criteria and adjuvant treatment regimens vary ... Data on guidelines for adjuvant treatment in European retinoblastoma referral centres were collected in an online survey among all members of the European Retinoblastoma Group (EURbG) network. Extended information was gathered via ...
Tópico(s): Brain Metastases and Treatment
2021 - Wiley | Pediatric Blood & Cancer
Chuandi Zhou, Xuyang Wen, Yi Ding, Jingwen Ding, Mei Jin, Zhenyin Liu, Sha Wang, Minglei Han, Hongfeng Yuan, Yi-shuang Xiao, Wu Li, Jian-Cang Wang, Yangjun Li, Jiawei Yu, Yuechun Wen, Juan Ye, Rong Liu, Zhijun Chen, Shangcai Xue, Wei Lu, Hongfei Liao, Jizhe Cui, Dan Zhu, Fang Lü, Song Tang, Yu Wu, Tseden Yangkyi, Guanghong Zhang, Miershalijiang Wubuli, Huiyu Guo, Xian Wang, Yanjin He, Xunlun Sheng, Qing Wang, Yingxiu Luo, Jiayan Fan, Jinlei Qi, Zhangsheng Yu, Jia Tan, Jianhong Liang, Xiantao Sun, Liwen Jin, Xinji Yang, Jing Zhang, Xunda Ji, Junyang Zhao, Renbing Jia, Xianqun Fan,
... the long-term prognosis of patients with advanced retinoblastoma with regard to overall survival and ocular salvage. ... Retrospective cohort study covering all 31 provinces (38 retinoblastoma treating centers) of mainland China. Participants One thousand ... eight patients diagnosed with group D or E retinoblastoma from January 2006 through May 2016. Methods Chart ... In this cohort, 1172 patients (70%) had unilateral retinoblastoma, whereas 506 patients (30%) had bilateral disease. For ... from the eye-preserving group died. For bilateral retinoblastoma with the worse eye classified as group E, ...
Tópico(s): Corneal Surgery and Treatments
2021 - Elsevier BV | Ophthalmology
Bénédicte Desvoyes, Crisanto Gutiérrez,
Review31 August 2020Open Access Roles of plant retinoblastoma protein: cell cycle and beyond Bénédicte Desvoyes Bénédicte Desvoyes Centro de Biología Molecular Severo Ochoa, CSIC-UAM, Madrid, Spain Search for more papers ... CitationsPermissions ShareFacebookTwitterLinked InMendeleyWechatReddit Figures & Info Abstract The human retinoblastoma (RB1) protein is a tumor suppressor that negatively ... that cells of rare human tumors, such as retinoblastoma or sarcoma, harbor inactivating mutations in the retinoblastoma ...
Tópico(s): Plant Molecular Biology Research
2020 - Springer Nature | The EMBO Journal
Yacoub A. Yousef, Ibrahim AlNawaiseh, Mustafa Mehyar, Iyad Sultan, Maysa Al‐Hussaini, Imad Jaradat, Mona Mohammad, Reem AlJabari, Nakhleh Abu‐Yaghi, Carlos Rodríguez‐Galindo, Ibrahim Qaddoumi, Matthew W. Wilson,
... telemedicine-based twinning partnership and centralized care for retinoblastoma on survival and eye salvage. Design Four hundred seventy-eight retinoblastoma patients treated at a tertiary referral cancer center ( ... 2003 through 2019. Participants Four hundred seventy-eight retinoblastoma patients treated at KHCC after implementing a telemedicine- ... Research Hospital. Methods We reviewed the outcomes of retinoblastoma patients who were treated at KHCC after implementing ... Hospital, and we compared that with outcomes for retinoblastoma patients who were treated before implementing a telemedicine- ...
Tópico(s): Retinal and Optic Conditions
2020 - Elsevier BV | Ophthalmology
Kaitlyn Flegg, Maxwell J. Gelkopf, Sarah A. Johnson, Helen Dimaras,
Background: Retinoblastoma is a childhood cancer of the eye that can have lifelong effects on patients and families. The ... of this study was for people affected by retinoblastoma, clinicians and researchers to jointly determine the top 10 retinoblastoma research priorities in Canada. Methods: An adaptation of ... resident of Canada, and were a patient with retinoblastoma (or a family member or friend of someone diagnosed with retinoblastoma) or a clinician or researcher interested in retinoblastoma. Patients were full partners in study design and ...
Tópico(s): Head and Neck Surgical Oncology
2020 - Canadian Medical Association | CMAJ Open
Huixue Wang, Jie Yang, Hui Pan, Mei-Chee Tai, Mohamed H. Maher, Renbing Jia, Shengfang Ge, Linna Lu,
... chemotherapy and enucleation usually fail to cure advanced retinoblastoma. We investigated the retinoblastoma immune microenvironment and the efficacy of the combination ... expressing NK-92MI (NK-92MIhCD16-GFP) cells on retinoblastoma cells in this study.Immunohistochemistry and flow cytometry ( ... to assess the expression level of GD2 in retinoblastoma tissues and cells. Gene set enrichment analysis (GSEA), immunohistochemisrztry and immunocytochemistry were conducted to assess the retinoblastoma immune microenvironment and the integrity of the blood- ...
Tópico(s): Hematopoietic Stem Cell Transplantation
2020 - Dove Medical Press | OncoTargets and Therapy
Zhe Sun, Ai Zhang, Mingyu Hou, Tao Jiang,
Retinoblastoma is the commonest eye cancer occurring in the pediatric population. Circular RNAs (circRNAs) are essential regulators ... and molecular basis of hsa_circ_0000034 in retinoblastoma progression. In the study, these series of experiments noted an upregulation of hsa_circ_0000034 in retinoblastoma cell lines and tissues. Retinoblastoma patients with raised hsa_circ_0000034 expressions were ... marked suppression in the proliferation and invasion of retinoblastoma cells in vitro. Mechanistically, hsa_circ_0000034 appeared ...
Tópico(s): Cancer-related molecular mechanisms research
2020 - Taylor & Francis | Bioengineered
Lata Singh, Mithalesh Kumar Singh, M. Moshahid A. Rizvi, Sameer Bakhshi, Rachna Meel, Neiwete Lomi, Seema Sen, Seema Kashyap,
... the tumor microenvironment of both primary and chemoreduced retinoblastoma and correlate them with clinicopathological parameters and patient ... 118 cases received chemotherapy/radiotherapy before enucleation (chemoreduced retinoblastoma). Immunohistochemistry, qRT-PCR and western blotting were performed ... of immune checkpoint markers in primary and chemoreduced retinoblastoma. Tumor microenvironment were different for both primary and chemoreduced retinoblastoma. Expression of PD-1 was found in 29/ ... 48/118 (40.67%) in primary and chemoreduced retinoblastoma, respectively, whereas PD-L1 was expressed in 46/ ...
Tópico(s): Glioma Diagnosis and Treatment
2020 - Springer Science+Business Media | Cancer Immunology Immunotherapy
Xing Liu, Jianzhong He, Longbing Mao, Yanyan Zhang, Wenwen Cui, Sujuan Duan, Alan Jiang, Yang Gao, Yi Sang, Guofu Huang,
Retinoblastoma (RB) is the most common intraocular malignant tumour in infants, and chemotherapy has been the primary ... Our study showed that PRMT5 was overexpressed in retinoblastoma and played an important role in retinoblastoma cell growth. EPZ015666 is a novel PRMT5 inhibitor, and we found that it inhibited retinoblastoma cell proliferation and led to cell cycle arrest ... In brief, our study showed that PRMT5 promoted retinoblastoma growth, the PRMT5 inhibitor EPZ015666 inhibited retinoblastoma in ...
Tópico(s): Protein Degradation and Inhibitors
2020 - Elsevier BV | Experimental Eye Research
Duangporn Saengwimol, Pamorn Chittavanich, Natanan Laosillapacharoen, Atthapol Srimongkol, Vijender Chaitankar, Duangnate Rojanaporn, Rangsima Aroonroch, Bhoom Suktitipat, Chonticha Saisawang, Saovaros Svasti, Suradej Hongeng, Rossukon Kaewkhaw,
... co-amplified with MYCN in pediatric cancers, including retinoblastoma. MYCNOS encodes several RNA variants whose functions have not been elucidated in retinoblastoma. Thus, we attempted to identify MYCNOS variants in retinoblastoma and aimed to decipher the role of MYCNOS ... 1 (MYCNOS1) on the activity of MYCN-amplified retinoblastoma. Methods: The profiles of MYCNOS variants and MYCN status were determined in 17 retinoblastoma tissues, cell lines, retinas, and retinal organoids. A ... conducted in patient-derived tumor cells and in retinoblastoma cell lines via short hairpin RNA-mediated gene ...
Tópico(s): Cancer, Hypoxia, and Metabolism
2020 - Cadmus Press | Investigative Ophthalmology & Visual Science
Pernille A. Gregersen, Maja Halgren Olsen, Steen F. Urbak, Mikkel Funding, Susanne Oksbjerg Dalton, Jens Overgaard, Jan Alsner,
Importance In heritable retinoblastoma, there is a significantly increased risk of second primary cancers (SPCs). Improved knowledge about the incidence and influence of ... treatment is important during therapy for patients with retinoblastoma. Objective To assess the incidence of SPC in patients diagnosed with retinoblastoma in Denmark from 1943 to 2013 with a ... containing complete data on all patients diagnosed with retinoblastoma , and obtained from the Danish Cancer Registry, which ... on 323 patients were included. Exposures Heritability and retinoblastoma treatment. Main Outcomes and Measures Standardized incidence rate, ...
Tópico(s): Brain Metastases and Treatment
2020 - American Medical Association | JAMA Network Open
Ido Didi Fabian, Abdallah Elhassan, Shehu U. Abdullahi, Rula Ahmed Abdulqader, Sahadatou Adamou Boubacar, Dupe Ademola-Popoola, Adedayo Adio, Armin R. Afshar, Priyanka Aggarwal, AE Aghaji, Alia Ahmad, Marliyanti N. R. Akib, Lamis Al Harby, Mouroge H. Al Ani, Aygun Alakbarova, S. Alarcón Portabella, Safa A. Faraj, Ana Patricia Alcasabas, Saad Al-Dahmash, Amanda Alejos, Ernesto Alemany-Rubio, Amadou I Alfa Bio, Yvania Alfonso Carreras, Christiane Al‐Haddad, Hamoud H. Y. Al-Hussaini, Amany Ali, Donjeta B. Alia, Mazin Faisal Al‐Jadiry, Usama Al‐Jumaily, Hind M. Alkatan, Charlotta All‐Eriksson, Ali A. R. M. Al-Mafrachi, Argentino A Almeida, Khalifa M Alsawidi, Athar Abdul Samad Majeed Al-Shaheen, Entissar Hadi Al-Shammary, Primawita O. Amiruddin, Antonino Romanzo, Nick Astbury, Hatice Tuba Atalay, L.–O. Atchaneeyasakul, Rose Atsiaya, Taweevat Attaseth, Than Aung, Silvia González Ayala, Baglan Baizakova, Julia Balaguer, Ruhengiz Balayeva, Walentyna Balwierz, Honorio Barranco, Covadonga Bascarán, Maja Popović, Raquel Benavides, Sarra Benmiloud, Nissrine Bennani Guebessi, R. Bérété, Jesse L. Berry, Anirban Bhaduri, Sunil Kumar Bhat, Shelley J. Biddulph, Eva Biewald, Nadia Bobrova, Marianna Boehme, H. Culver Boldt, Maria Teresa B.C. Bonanomi, Norbert Bornfeld, Gabrielle C. Bouda, H. Bouguila, Amaria Boumedane, Rachel C. Brennan, Bénédicte G. Brichard, Jassada Buaboonnam, Patricia Calderón-Sotelo, Doris A. Calle Jara, Jayne E Camuglia, Miriam R. Cano, Michael Capra, Nathalie Cassoux, Guilherme Castela, Luis Castillo, Jaume Catalá‐Mora, Guillermo Chantada, Shabana Chaudhry, Sonal S. Chaugule, Argudit Chauhan, Bhavna Chawla, Violeta Chernodrinska, Faraja Chiwanga, Tsengelmaa Chuluunbat, Krzysztof Cieślik, Ruellyn L. Cockcroft, Codruta Comsa, Zélia M. Corrêa, Maria G. Correa Llano, Timothy W. Corson, Kristin E. Cowan-Lyn, Monika Csóka, Xuehao Cui, Isac V. Da Gama, Wantanee Dangboon, Anirban Das, Sima Das, Jacquelyn M. Davanzo, Alan Davidson, Patrick De Potter, Karina Quintero Delgado, Hakan Demirci, Laurence Desjardins, Rosdali Díaz Coronado, Helen Dimaras, Andrew Dodgshun, Craig Donaldson, Carla Macedo, Monica Dragomir, Yi Du, Magritha Du Bruyn, Kemala S. Edison, I Wayan Eka Sutyawan, A. El Kettani, Amal Elbahi, James E. Elder, Dina Elgalaly, Alaa Elhaddad, Moawia Mohammed Ali Elhassan, Mahmoud M. Elzembely, Vera Adobea Essuman, Ted Grimbert A Evina, Zehra Fadoo, Adriana Fandiño, Mohammad Faranoush, Oluyemi Fasina, Delia D. P. G. Fernández, Ana Fernández‐Teijeiro, Allen Foster, Shahar Frenkel, Ligia D. Fu, Soad Fuentes‐Alabi, Brenda L. Gallie, Moira Gandiwa, Juan Luis Garcı́a, David García Aldana, Pascale Gassant, Jennifer Geel, Fariba Ghassemi, Ana V. Girón, Zelalem Gizachew, Marco A. Goenz, Aaron S. Gold, Maya Goldberg-Lavid, Glen A. Gole, Nir Gomel, Efren Gonzalez, Graciela González Pérez, Liudmira González-Rodríguez, Henry N. Garcia Pacheco, Jaime Graells, Liz Green, Pernille A. Gregersen, Nathália Grigorovski, K.M. Guedenon, Sanjeeva Gunasekera, Kaan Gündüz, Himika Gupta, SK Gupta, Theodora Hadjistilianou, Patrick Hamel, Syed Ahmer Hamid, Norhafizah Hamzah, Eric Hansen, J. William Harbour, M. Elizabeth Hartnett, Murat Hasanreisoğlu, Sadiq Hassan, Shadab Hassan, Stanislava Hederová, José Hernández, Lorelay Marie Carcamo Hernandez, Laila Hessissen, Diriba Fufa, Laura C. Huang, G. Baker Hubbard, Marlies Hummlen, Kristína Husáková, Allawi Noor Hussein Al-Janabi, Ida Russo, Vesna R. Ilic, Vivekaraj Jairaj, Irfan Jeeva, Helen Jenkinson, Xunda Ji, Dong Hyun Jo, Kenneth P. Johnson, William J. Johnson, Michael W. Jones, Théophile Kabesha, Rolande Kaboré, Swathi Kaliki, Abubakar Kalinaki, Mehmet Kantar, Ling-Yuh Kao, Tamar Kardava, Rejin Kebudi, Tomáš Kepák, Naama Keren‐Froim, Zohora Jameela Khan, Hussain Ahmad Khaqan, Phara Khauv, Wajiha Jurdi Kheir, Vikas Khetan, Alireza Khodabande, Zaza Khotenashvili, Jonathan W. Kim, Jeong Hun Kim, Hayyam Kıratlı, Tero Kivelä, Artur Klett, Jess Elio Kosh Komba Palet, Dalia Krivaitienė, Mariana Kruger, Kittisak Kulvichit, Mayasari W. Kuntorini, Alice Kyara, Eva S. Lachmann, Carol P. Lam, Geoffrey C. Lam, Scott A. Larson, Slobodanka Latinović, Kelly D. Laurenti, Bao Han A. Le, Karin Lecuona, Amy A. Leverant, Cairui Li, Ben Limbu, Quah Boon Long, Juan Pablo López, Robert Mbuli Lukamba, Livia Lumbroso‐Le Rouic, Sandra Luna‐Fineman, Delfitri Lutfi, Lesia Lysytsia, George N. Magrath, Amita Mahajan, Abdul Rahim Majeed, Erika Maka, Mayuri Makan, Emil Kojoshovich Makimbetov, Chatonda Manda, Nieves Martín Begué, Lauren Mason, John O. Mason, Ibrahim Matende, Miguel A. Materin, Clarissa C. D. S. Mattosinho, Marchelo Matua, Ismail Mayet, Freddy B Mbumba, John D. McKenzie, Aurora Medina‐Sansón, Azim Mehrvar, Aemero Abateneh Mengesha, Vikas Menon, Gary John V. Mercado, Marilyn B. Mets, Edoardo Midena, Divyansh K. C. Mishra, Furahini G. Mndeme, Ahmed Abdalla Mohamedani, Mona Mohammad, Annette C. Moll, Margarita M. Montero, Rosa A. Morales, Claude Moreira, Prithvi Mruthyunjaya, Mchikirwa S Msina, Gerald Msukwa, Sangeeta Sanjay Mudaliar, Kangwa I. M. Muma, Francis L. Munier, Gabriela Murgoi, Timothy G. Murray, Kareem O. Musa, Asma Mushtaq, Hamzah Mustak, Okwen M Muyen, Gita Naidu, Akshay Gopinathan Nair, Л. В. Науменко, P.A. Ndoye Roth, Yetty Movieta Nency, В. В. Нероев, Hang Ngo, Rosa M. Nieves, Marina Nikitović, Elizabeth Dennis Nkanga, Henry Nkumbe, Murtuza Nuruddin,
Early diagnosis of retinoblastoma, the most common intraocular cancer, can save both a child's life and vision. However, anecdotal evidence suggests that ... late. To our knowledge, the clinical presentation of retinoblastoma has never been assessed on a global scale. To report the retinoblastoma stage at diagnosis in patients across the world ... advanced disease at diagnosis. A total of 278 retinoblastoma treatment centers were recruited from June 2017 through ... cross-sectional analysis of treatment-naive patients with retinoblastoma who were diagnosed in 2017. Age at presentation, ...
American Medical Association
Lili Song, Yanxia Huang, Xinli Zhang, Shaoping Han, Min Hou, Hongxia Li,
... miRs) has been proved in the pathogenesis of retinoblastoma. miR-224-3p is demonstrated to be involved ... the underlying mechanism of miR-224-3p in retinoblastoma is yet to be investigated. Therefore, this study ... the regulation of miR-224-3p in human retinoblastoma. Methods: The expression pattern of miR-224-3p and large tumor suppressor 2 (LATS2) in retinoblastoma was measured by reverse transcription quantitative polymerase chain ... determining downstream genes. Results: LATS2 was downregulated in retinoblastoma, and its overexpression promoted apoptosis and suppressed proliferation ...
Tópico(s): Cell death mechanisms and regulation
2020 - Cadmus Press | Investigative Ophthalmology & Visual Science
Wen Geng, Jiaxu Ren, Huimin Shi, Feng Qin, Xiaohe Xu, Sheng Xiao, Yisheng Jiao, Aiyuan Wang,
Abstract Retinoblastoma is the most common intraocular cancer with metastatic potential affecting infants and children. Although chemotherapy is available for retinoblastoma, side effects and drug resistance are frequent. Rpl41 , ... in combination with chemotherapy for the treatment of retinoblastoma and to investigate the mechanism of their combined ... alone decreased the viability, migration, and invasion of retinoblastoma Y79 and Weri‐Rb1 cells, in addition to ... protein levels showed a significantly decreased trend in retinoblastoma specimens, whereas ATF4 protein levels tended to be ...
Tópico(s): Lung Cancer Research Studies
2020 - Wiley | Journal of Cellular Physiology