From David Watts, By Michael Hatfield Political Reporter, By Melvyn Westlake, By Hugh Noyes Parliamentary Correspondent, From Michael Leapman, By Donald Macintyre Labour Reporter, By Arthur Reed Air Correspondent, By John Young, By Our Labour Reporter, From Our Correspondent, From Ronald Faux, By Our Local Government Correspondent, From Christopher Walker, By Our Political Staff, By a Staff Reporter, By Our Medical Correspondent, By Roger Berthoud, By Diana Geddes Education Correspondent, By Simon Midgley, of The Times Highter Education Supplement, Tim Jones, By Kenneth Gosling Arts Reporter, By Peter Hennessy, By Our Arts Reporter, By Philip Howard, From Diana Geddes Education Correspondent, By Penny Symon, By Martin Huckerby Music Reporter, From Henry Stanhope Defence Correspondent, From Our Own Correspondent, From Ian Murray, From Charles Hargrove, From Nicholas Ashford, From Hasan Akktar, From David Cross, From Edward Mortimer, From David A. Andelman, From Eric Marsden, From Dessa Trevisan, Pat Healy Social Services Correspondent, Dr Tony Smith Medical Correspondent, Paul Overy, Paul Griffiths, Barry Millington, Stanley Reynolds, William Gaunt, Irving Wardle, Ned Chaillet, William Mann, By Norman Fox Football Correspondent, By Peter West Rugby Correspondent, By Peter Ryde Golf Correspondent, By Cliff Temple Athletics Correspondent, By Michael Seely, By Srikumar Sen, By John Blunsden, By Rex Bellamy, Bernard Levin, PHS, Henry Stanhope Defence Correspondent, TIM RICE, , TOM CLARKE., P. S. ATIYAH, RUPERT CROSS., RONALD DWORKIN, , A. M. HONORE, , J. K. B. M. NICHOLAS., D. R. BERRIDGE, , JOHN HAMILTON, , JOHN NICHOLSON, H. B. BROOKS-BAKER, GRAHAM T COLLINS, JOHN SYKES., CALDECOTE, , ERNEST B. HAMLEY., GOODMAN, K. C. CHAN., MALCOLM MACKAY., OSWALD M. GIBBS, , DOUCLAS BROWN., By Geraldine Norman Sale Room Correspondent, From John Chartres, From Our Own Correspondent., By Our Bridge Correspondent, F.R.B., By Bryan Appleyard, From Michael Hornsby, By Ronald Pullen, Banking Correspondent, By Our Industrial Correspondnet, Frank Vogl, By Peter Hill, By David Blake Economics Correspondent, Christopher Thomas, By R. W. Shakespeare, By Edward Townsend, By Our Commercial Editor, By David Blake, WILLIAM GOODHART, RUSSELL WOOD., PETER FATHARLY, , BY THE FINANCIAL EDITOR, Eric Wigham, John Earle, From John Huxley, By Patricia Tisdall, By Derek Harris Commercial Editor, Kenneth Owen, By Ashley Druker, By Tony May, By Richard Allen, By Michael Clark, By Alison Mitchell, D.B., A.C., N.G., Maurice Bommensath, Piero de Garzarolli, Michael Hornsby, J Jacques Ferry, Jacqueline Grapin, Philippe Lemaitre, Bruno Dethomas, Piaggio, Renzo Villare, Hans Baumann, Erwin Schneider, Pangloss,
... Limited, Halifax, M. J. H. Nightingale & Co. Limited, Cao-Cpp, The Royal Borough Of Kensington And Chelsea, ...
1977 - Gale Group | TDA
Kathryn Mickett, Cynthia M. Morton, Jinian Feng, P. Li, Micah Simmons, D. Cao, Rex A. Dunham, Z. Liu,
Amplified fragment length polymorphism (AFLP) was used to analyze the genetic diversity of domestic stocks of channel catfish (Ictalurus punctatus). Sixteen populations within Alabama (USA) were surveyed using five primer combinations. A total of 454 reproducible, polymorphic bands were detected from 282 individuals, with an average heterozygosity of 0.135. The percentage of polymorphic loci varied greatly within distinct populations, ranging from 18.26% to 100%. Research populations tended to have ...
Tópico(s): Fish Ecology and Management Studies
2003 - Elsevier BV | Aquaculture
Zhanjiang Liu, Attila Karsi, Ping Li, Dongfeng Cao, Rex A. Dunham,
Abstract Catfish is the major aquaculture species in the United States. The hybrid catfish produced by crossing channel catfish females with blue catfish males exhibit a number of desirable production traits, but their mass production has been difficult. To introduce desirable genes from blue catfish into channel catfish through introgression, a genetic linkage map is helpful. In this project, a genetic linkage map was constructed using amplified fragment length polymorphism (AFLP). A total of 607 ...
Tópico(s): Genetic Mapping and Diversity in Plants and Animals
2003 - Oxford University Press | Genetics
Zhenlin Ju, Attila Karsi, Arif Kocabas, Andrea Patterson, Ping Li, Dongfeng Cao, Rex A. Dunham, Zhanjiang Liu,
Tópico(s): RNA and protein synthesis mechanisms
2000 - Elsevier BV | Gene
Wenjie Lai, Lin Cao, Rex Xiao Tan, Yung Chuen Tan, Xiaoguo Li, Phuoc Thien Phan, Anthony Meng Huat Tiong, Swee Chuan Tjin, Soo Jay Phee,
Tópico(s): Intraoperative Neuromonitoring and Anesthetic Effects
2019 - Springer Science+Business Media | Annals of Biomedical Engineering
Wenjie Lai, Lin Cao, Rex Xiao Tan, Phuoc Thien Phan, Jianzhong Hao, Swee Chuan Tjin, Soo Jay Phee,
This article presents a novel force sensor to detect the distal force of tendon-sheath mechanisms (TSMs) in flexible endoscopic surgical robots. We propose to measure the compression force on the sheath at the distal end so that the tension force on the tendon, which equals the compression force on the sheath, can be obtained. With this approach, a new force sensor made up of a 1 mm fiber Bragg grating attached to a 3 mm long nitinol tube was developed to measure the compression force exerted on ...
Tópico(s): Advanced Surface Polishing Techniques
2019 - Institute of Electrical and Electronics Engineers | IEEE/ASME Transactions on Mechatronics
Ruidong Li, Wenwen Zhang, Zhengjian Yan, Wei Liu, Jiaming Fan, Yixiao Feng, Zongyue Zeng, Daigui Cao, Rex C. Haydon, Hue H. Luu, Zhong‐Liang Deng, Tong‐Chuan He, Yulong Zou,
Long non-coding RNAs are important regulators of biological processes, but their roles in the osteogenic differentiation of mesenchymal stem cells (MSCs) remain unclear. Here we investigated the role of murine HOX transcript antisense RNA (mHotair) in BMP9-induced osteogenic differentiation of MSCs using immortalized mouse adipose-derived cells (iMADs). Touchdown quantitative polymerase chain reaction analysis found increased mHotair expression in bones in comparison with most other tissues. Moreover, ...
Tópico(s): Circular RNAs in diseases
2021 - Impact Journals LLC | Aging
Ming W. Chou, Ming Lu, Rex A. Pegram, Peng Cao, Jin Kong, R HART,
Young adult male Fischer rats maintained on a reduced calorie diet (60% of ad libitum food consumption) for 6 weeks showed a decrease in the binding of aflatoxin B1 (AFB1) to hepatic or renal nuclear DNA and a reduction of AFB1-induced hepatocellular damage. Repeated dosing of rats with AFB1 resulted in the inhibition of hepatic and renal DNA synthesis measured by [3H]thymidine incorporation. However, the rate of DNA synthesis was greater in ad libitum (AL) rats than in calorically restricted (CR) animals. ...
Tópico(s): Genetically Modified Organisms Research
1993 - Elsevier BV | Mechanisms of Ageing and Development
Yangli Pei, Yingjie Wu, Jie Cao, Yinghe Qin,
Tópico(s): Sperm and Testicular Function
2012 - Elsevier BV | Livestock Science
Benjamin P. Song, Surbhi Jain, Selena Y. Lin, Quan Chen, Timothy M. Block, Wei Song, Dean E. Brenner, Ying‐Hsiu Su,
... R. Harrington J.J. Hussain F.T.N. Cao X. Loprinzi C.L. Levine T.R. Rex D.K. Ahnen D. Knigge K.L. Lance ...
Tópico(s): Immunotherapy and Immune Responses
2012 - Elsevier BV | Journal of Molecular Diagnostics
Xin Wang, Xingye Wu, Zhonglin Zhang, Chao Ma, Tingting Wu, Shengli Tang, Zongyue Zeng, Shifeng Huang, Gong Cheng, Chengfu Yuan, Linghuan Zhang, Yixiao Feng, Bo Huang, Wei Liu, Bo Zhang, Yi Shen, Wenping Luo, Xi Wang, Bo Liu, Lei Yan, Zhenyu Ye, Ling Zhao, Daigui Cao, Lijuan Yang, Xian Chen, Rex C. Haydon, Hue H. Luu, Bing Peng, Xubao Liu, Tong‐Chuan He,
Pancreatic ductal adenocarcinoma (PDAC) is one of the most deadly malignancies with <5% five-year survival rate due to late diagnosis, limited treatment options and chemoresistance. There is thus an urgent unmet clinical need to develop effective anticancer drugs to treat pancreatic cancer. Here, we study the potential of repurposing monensin as an anticancer drug for chemo-resistant pancreatic cancer. Using the two commonly-used chemo-resistant pancreatic cancer cell lines PANC-1 and MiaPaCa-2, we ...
Tópico(s): Pancreatic and Hepatic Oncology Research
2018 - Nature Portfolio | Scientific Reports
Willie G. Harris, M. M. Fisher, Xinde Cao, Todd Z. Osborne, L. Rex Ellis,
Fine sediments in shallow water bodies such as Lake Okeechobee are prone to resuspension. Predominantly inorganic "mud" sediment that covers approximately 670 km2 of the lake has been recognized as a persistent source of turbidity. The objective of this study was to determine if mineral components of sediments in Lake Okeechobee and water conveyances of the northern Everglades also occur as suspended sediment and hence constitute a potential abiotic contributor to turbidity. Sediment samples were ...
Tópico(s): Geochemistry and Elemental Analysis
2007 - Wiley | Journal of Environmental Quality
Chong Gao, Qian Xie, Yuwen Zhang, Yanli Su, Ping Zhao, Brian Cao, Kyle Furge, Jan Sun, Karen Rex, Tao Osgood, Angela Coxon, Teresa L. Burgess, George F. Vande Woude,
Abstract Hepatocyte growth factor/scatter factor (HGF/SF) and its receptor, c-Met, have been implicated in the growth and progression of a variety of solid human tumors. Thus, inhibiting HGF/SF:c-Met signaling may provide a novel therapeutic approach for treating human tumors. We have generated and characterized fully human monoclonal antibodies that bind to and neutralize human HGF/SF. In this study, we tested the effects of the investigational, human anti-human HGF/SF monoclonal antibody, AMG 102, ...
Tópico(s): Pancreatic function and diabetes
2009 - American Association for Cancer Research | Molecular Cancer Therapeutics
Young Joo Sun, Yasuhiro Mochizuki, Philip W. Majerus,
... m Tris, pH 8.0.Cell Lines—293T-Rex cells (Clontech) stably expressing 5/6-kinase or pcDNA4.0 vector-transfected cells were described previously (9Wilson M.P. Sun Y. Cao L. Majerus P.W. J. Biol. Chem. 2001; ...
Tópico(s): interferon and immune responses
2003 - Elsevier BV | Journal of Biological Chemistry
Hongzhi Zou, William R. Taylor, Jonathan J. Harrington, Fareeda Taher Nazer Hussain, Xiaoming Cao, Charles L. Loprinzi, Theodore R. Levine, Douglas K. Rex, Dennis J. Ahnen, Kandice Knigge, Peter Lance, Xuan Jiang, Jeremy C. Smith, David A. Ahlquist,
Background & AimsCurrent stool DNA tests identify about half of individuals with colorectal cancers and miss most individuals with advanced adenomas. We developed a digital melt curve (DMC) assay to quantify low-abundance mutations in stool samples for detection of colorectal neoplasms and compared this test with other approaches.MethodsWe combined a melt curve assay with digital polymerase chain reaction and validated the quantitative range. We then evaluated its ability to detect neoplasms in 2 clinical ...
Tópico(s): Colorectal Cancer Screening and Detection
2008 - Elsevier BV | Gastroenterology
Arif Kocabas, Ping Li, Dongfeng Cao, Attila Karsi, Chongbo He, Andrea Patterson, Zhenlin Ju, Rex A. Dunham, Zhanjiang Liu,
Tópico(s): interferon and immune responses
2002 - Springer Science+Business Media | Marine Biotechnology
Zhimin Cao, Julianne Cook Botelho, Robert Rej, Hubert W. Vesper, J. Rex Astles,
We reported observations on analytical performance in testosterone measurements of various methods/assays from the study carried out using accuracy-based proficiency testing (PT) during 2012–2013. In 2016, we re-evaluated analytical performance of testosterone assays using accuracy-based PT to assess effectiveness of CDC efforts toward standardization. Five single-donor human serum samples from female and male adult donors were analyzed for testosterone by New York State Department of Health-certified ...
Tópico(s): Pharmacological Effects and Assays
2019 - Elsevier BV | Clinical Biochemistry
Shaofeng Xiong, Zhangfu Yuan, Cong Xu, Liang Xi,
... the novel combined fluidized bed. The difference between REx and corresponding REq is mainly attributed to short retention time (about 1 s) of materials in combined fluidized bed and carbochlorination of oxide impurities contained in titanium slag, such as CaO, MgO and SiO2.
Tópico(s): Thermal and Kinetic Analysis
2010 - Elsevier BV | Transactions of Nonferrous Metals Society of China
Yun Teng, Jingyao Mu, Xin Hu, Abhilash Samykutty, Xiaoying Zhuang, Zhongbin Deng, Lifeng Zhang, Pengxiao Cao, Jun Yan, Donald M. Miller, Huang-Ge Zhang,
... 2 , Zhongbin Deng 2 , Lifeng Zhang 2 , Pengxiao Cao 2 , Jun Yan 2 , Donald Miller 2 , Huang-Ge Zhang 1, 2, 3 1 Robley Rex VA Medical Center, Louisville, KY 40206, USA 2 ...
Tópico(s): MicroRNA in disease regulation
2016 - Impact Journals LLC | Oncotarget
Elam Coalson, Elliot S. Bishop, Wei Liu, Yixiao Feng, Mia Spezia, Bo Liu, Yi Shen, Di Wu, Scott Du, Alexander J. Li, Zhenyu Ye, Ling Zhao, Daigui Cao, Alissa Li, Ofir Hagag, Alison Deng, Winny Liu, Mingyang Li, Rex C. Haydon, Lewis L. Shi, Aravind Athiviraham, Michael J. Lee, Jennifer Moriatis Wolf, Guillermo A. Ameer, Tong‐Chuan He, Russell R. Reid,
With the significant financial burden of chronic cutaneous wounds on the healthcare system, not to the personal burden mention on those individuals afflicted, it has become increasingly essential to improve our clinical treatments. This requires the translation of the most recent benchtop approaches to clinical wound repair as our current treatment modalities have proven insufficient. The most promising potential treatment options rely on stem cell-based therapies. Stem cell proliferation and signaling ...
Tópico(s): Planarian Biology and Electrostimulation
2019 - Elsevier BV | Genes & Diseases
Kazuhisa Maeda, Haiming Cao, Keita Kono, Cem Z. Görgün, Masato Furuhashi, K. Teoman Uysal, Qiong Cao, Gen‐ichi Atsumi, Harry Malone, Bala Krishnan, Yasuhiko Minokoshi, Barbara B. Kahn, Rex A. Parker, Gökhan S. Hotamışlıgil,
Fatty acid binding proteins (FABPs) are cytosolic fatty acid chaperones whose biological role and mechanisms of action are not well understood. Here, we developed mice with targeted mutations in two related adipocyte FABPs, aP2 and mal1, to resolve their role in systemic lipid, glucose, and energy metabolism. Mice lacking aP2 and mal1 exhibited a striking phenotype with strong protection from diet-induced obesity, insulin resistance, type 2 diabetes, and fatty liver disease. These mice have altered ...
Tópico(s): Peroxisome Proliferator-Activated Receptors
2005 - Cell Press | Cell Metabolism
Yue Cao, Pan Yu, Qingmin You, Rex L. Lowe, David M. Williams, Quanxi Wang, John Patrick Kociolek,
A new species of Tabularia, Tabularia sinensis, is described from the inland Poyang Lake (Jiangxi Province), the largest lake in China. The description is based on light and scanning electron microscope observations of valve and girdle elements. Given the diversity of forms in the genus, the relationships and status of the genus was investigated in the context of the other known species in the genus and to ascertain if Tabularia, as originally circumscribed, remains monophyletic.
Tópico(s): Leech Biology and Applications
2018 - Q15088586 | Phytotaxa
Yong Liu, Huili Wang, Jinhua Lu, Yi‐Liang Miao, Xinyan Cao, Ling Zhang, Xiaoqing Wu, Fengrui Wu, Biao Ding, Rong Wang, Ming‐Jiu Luo, Wenyong Li, Jing‐He Tan,
Somatic cell nuclear transfer (SCNT) requires large numbers of matured oocytes. In vitro-matured (IVM) oocytes have been used in SCNT in many animals. We investigated the use of IVM oocytes in Rex rabbit SCNT using Rex rabbit ovaries obtained from a local abattoir. The meiotic ability of oocytes isolated from follicles of different diameters was studied. Rex rabbit SCNT was optimized for denucleation, activation, and donor cell synchronization. Rex rabbit oocytes grew to the largest diameter (110 μm) ...
Tópico(s): Renal and related cancers
2016 - Mary Ann Liebert, Inc. | Cellular Reprogramming
Linghuan Zhang, Qing Luo, Yi Shu, Zongyue Zeng, Bo Huang, Yixiao Feng, Bo Zhang, Xi Wang, Lei Yan, Zhenyu Ye, Ling Zhao, Daigui Cao, Lijuan Yang, Xian Chen, Bin Liu, William Wagstaff, Russell R. Reid, Hue H. Luu, Rex C. Haydon, Michael J. Lee, Jennifer Moriatis Wolf, Zhou Fu, Tong‐Chuan He, Quan Kang,
Mesenchymal stem cells (MSCs) are ubiquitously-existing multipotent progenitors that can self-renew and differentiate into multiple lineages including osteocytes, chondrocytes, adipocytes, tenocytes and myocytes. MSCs represent one of the most commonly-used adult progenitors and serve as excellent progenitor cell models for investigating lineage-specific differentiation regulated by various cellular signaling pathways, such as bone morphogenetic proteins (BMPs). As members of TGFβ superfamily, BMPs ...
Tópico(s): Cancer-related gene regulation
2019 - Elsevier BV | Genes & Diseases
Qingmin You, Yue Cao, Pan Yu, John Patrick Kociolek, Lixuan Zang, Bo Wu, Rex L. Lowe, Quanxi Wang,
Three new subaerial species of Achnanthidium are examined and described from a karst landform of central-south China based on light and scanning electron microscopy observations, and are compared with similar taxa worldwide.A. mediolanceolatum sp.nov. is elliptical-lanceolate, not linear-lanceolate as is more typical in this genus, as well as having a bow-tie shaped central area on the raphe valve and a large lanceolate axial area on the rapheless valve, features which together make it easy to distinguish ...
Tópico(s): Microbial Community Ecology and Physiology
2019 - Česká algologická společnost | Fottea
Yannian Gou, Yaguang Weng, Qian Chen, Jinghong Wu, Hao Wang, Jiamin Zhong, Yang Bi, Daigui Cao, Piao Zhao, Xiangyu Dong, Meichun Guo, William Wagstaff, Bryce Hendren‐Santiago, Connie Chen, Andrew Youssef, Rex C. Haydon, Hue H. Luu, Russell R. Reid, Le Shen, Tong‐Chuan He, Jiaming Fan,
Effective and safe liver-directed gene therapy has great promise in treating a broad range of liver diseases. While adenoviral (Ad) vectors have been widely used for efficacious in vivo gene delivery, their translational utilities are severely limited due to the short duration of transgene expression and solicitation of host immune response. Used as a promising polymeric vehicle for drug release and nucleic acid delivery, carboxymethyl chitosan (CMC) is biocompatible, biodegradable, anti-microbial, ...
Tópico(s): Pancreatic function and diabetes
2022 - Wiley | Bioengineering & Translational Medicine
Sheng Cao, Janet Yao, Timothy J. McCabe, Qing Yao, Zvonimir S. Katušić, William C. Sessa, Vijay H. Shah,
... cell line) (14Jones S. Howell K. Henley J. Cao H. McNiven M. Science. 1998; 279: 573-577Crossref PubMed Scopus (269) Google Scholar), and stably transfected eNOS-GFP ECV 304 cells (21Sowa G. Liu J. Papapetropoulos A. Rex-Haffner M. Hughes T. Sessa W. J. Biol. ...
Tópico(s): Ion Transport and Channel Regulation
2001 - Elsevier BV | Journal of Biological Chemistry
Jiaming Fan, Yixiao Feng, Ruyi Zhang, Wenwen Zhang, Yi Shu, Zongyue Zeng, Shifeng Huang, Linghuan Zhang, Bo Huang, Di Wu, Bo Zhang, Xi Wang, Lei Yan, Zhenyu Ye, Ling Zhao, Daigui Cao, Lijuan Yang, Xian Chen, Bin Liu, William Wagstaff, Fang He, Xiaoxing Wu, Jing Zhang, Jennifer Moriatis Wolf, Michael J. Lee, Rex C. Haydon, Hue H. Luu, Ailong Huang, Tong‐Chuan He, Shujuan Yan,
MicroRNAs (miRNAs) are ~22 nucleotide noncoding RNAs that are involved in virtually all aspects of cellular process as their deregulations are associated with many pathological conditions. Mature miRNAs (mMIRs) are generated through a series of tightly-regulated nuclear and cytoplasmic processing events of the transcribed primary, precursor and mMIRs. Effective manipulations of miRNA expression enable us to gain insights into miRNA functions and to explore potential therapeutic applications. Currently, ...
Tópico(s): Circular RNAs in diseases
2019 - Springer Nature | Cancer Gene Therapy
Xi Wang, Chengfu Yuan, Bo Huang, Jiaming Fan, Yixiao Feng, Alexander J. Li, Bo Zhang, Lei Yan, Zhenyu Ye, Ling Zhao, Daigui Cao, Lijuan Yang, Di Wu, Xian Chen, Bin Liu, William Wagstaff, Fang He, Xiaoxing Wu, Huaxiu Luo, Jing Zhang, Meng Zhang, Rex C. Haydon, Hue H. Luu, Michael J. Lee, Jennifer Moriatis Wolf, Ailong Huang, Tong‐Chuan He, Zongyue Zeng,
As an important post-transcriptional regulatory machinery mediated by ∼21nt short-interfering double-stranded RNA (siRNA), RNA interference (RNAi) is a powerful tool to delineate gene functions and develop therapeutics. However, effective RNAi-mediated silencing requires multiple siRNAs for given genes, a time-consuming process to accomplish. Here, we developed a user-friendly system for single-vector-based multiplex siRNA expression by exploiting the unique feature of restriction endonuclease BstXI. ...
Tópico(s): MicroRNA in disease regulation
2019 - American Chemical Society | ACS Synthetic Biology
Z. Zhang, Jianxiang Liu, Zongyue Zeng, Jiaming Fan, Shifeng Huang, Linghuan Zhang, Bo Zhang, Xi Wang, Yixiao Feng, Zhenyu Ye, Ling Zhao, Daigui Cao, Lijuan Yang, Mikhail Pakvasa, Bin Liu, William Wagstaff, Xiaoxing Wu, Huaxiu Luo, Jing Zhang, Meng Zhang, Fang He, Yukun Mao, Huimin Ding, Yongtao Zhang, Changchun Niu, Rex C. Haydon, Hue H. Luu, Michael J. Lee, Jennifer Moriatis Wolf, Zengwu Shao, Tong‐Chuan He,
Understanding the bone and musculoskeletal system is essential to maintain the health and quality of life of our aging society. Mesenchymal stem cells (MSCs) can undergo self-renewal and differentiate into multiple tissue types including bone. We demonstrated that BMP9 is the most potent osteogenic factors although molecular mechanism underlying BMP9 action is not fully understood. Long noncoding RNAs (lncRNAs) play important regulatory roles in many physiological and/or pathologic processes. Here, ...
Tópico(s): MicroRNA in disease regulation
2019 - Impact Journals LLC | Aging