Leonor Côrte‐Real, Ricardo G. Teixeira, Patrícia Gírio, Elisabeta Comsa, Alexis Moréno, Rachad Nasr, Hélène Baubichon‐Cortay, Fernando Avecilla, Fernanda Marques, M. Paula Robalo, Paulo Mendes, João P. Prates Ramalho, M. Helena García, Pierre Falson, Andreia Valente,
New ruthenium methyl-cyclopentadienyl compounds bearing bipyridine derivatives with the general formula [Ru(η5-MeCp)(PPh3)(4,4'-R-2,2'-bpy)]+ (Ru1, R = H; Ru2, R = CH3; and Ru3, R = CH2OH) have been synthesized and characterized by spectroscopic and analytical techniques. Ru1 crystallized in the monoclinic P21/ c, Ru2 in the triclinic P1̅, and Ru3 in the monoclinic P21/ n space group. In all molecular structures, the ruthenium center adopts a "piano stool" distribution. Density functional theory calculations ...
Tópico(s): Asymmetric Hydrogenation and Catalysis
2018 - American Chemical Society | Inorganic Chemistry
Produção Nacional
Revisado por pares
Maurício Corte Real da Silva, Ricardo Jacó de Oliveira, Maria Inês Gandolfo Conceição,
FUNDAMENTOS E OBJETIVO: O esporte tem um papel fundamental na reabilitação física de pacientes com lesão medular por ampliar as alternativas terapêuticas e favorecer a independência funcional. O estudo tem por objetivo conhecer os efeitos da natação sobre habilidades funcionais de pacientes com lesão medular. MÉTODOS: Foram selecionados 16 pacientes portadores de lesão medular, divididos em dois grupos: experimental e controle. Os grupos foram avaliados por meio da Medida de Independência Funcional ( ...
Tópico(s): Spinal Cord Injury Research
2005 - Sociedade Brasileira de Medicina do Esporte | Revista Brasileira de Medicina do Esporte
Produção Nacional
Revisado por pares
Juliana Dutra B. Rocha, Michelle T. C. Nascimento, Débora Decoté‐Ricardo, Suzana Côrte‐Real, Alexandre Morrot, Norton Heise, Marise P. Nunes, José O. Previato, Lúcia Mendonça‐Previato, George A. DosReis, Elvira M. Saraiva, Célio Geraldo Freire-de-Lima,
In the present study, we characterized the in vitro modulation of NETs (neutrophil extracellular traps) induced in human neutrophils by the opportunistic fungus Cryptococcus neoformans, evaluating the participation of capsular polysaccharides glucuronoxylomanan (GXM) and glucuronoxylomannogalactan (GXMGal) in this phenomenon. The mutant acapsular strain CAP67 and the capsular polysaccharide GXMGal induced NET production. In contrast, the wild-type strain and the major polysaccharide GXM did not induce ...
Tópico(s): Antifungal resistance and susceptibility
2015 - Nature Portfolio | Scientific Reports
Produção Nacional
Revisado por pares
Roberto Tedesco, Ricardo Luiz Smith, Suzana Côrte‐Real, Kátia da Silva Calabrese,
This paper aims to test the influence of route of infection (intravitreal and instillation) on the course of ocular toxoplasmosis in mice, using the Toxoplasma gondii Me-49 strain. All mice inoculated intravitreally or by instillation presented the same pattern of infection. Using either route, parasites were observed in the retinal vessel with the formation of a glial reaction in the inner plexiforme layer and discontinuity of the pigmented epithelium of the retina 7 days after infection. However, ...
Tópico(s): Rabies epidemiology and control
2005 - Cambridge University Press | Parasitology
Produção Nacional
Revisado por pares
Roberto Tedesco, Ricardo Luiz Smith, Suzana Côrte‐Real, Kátia da Silva Calabrese,
Tópico(s): Ocular Diseases and Behçet’s Syndrome
2004 - Springer Science+Business Media | Parasitology Research
Produção Nacional
Revisado por pares
Joana D’Arc S. Trindade, Célio Geraldo Freire-de-Lima, Suzana Côrte‐Real, Débora Decoté‐Ricardo, Marco Edílson Freire de Lima,
Chagas disease is a neglected illness caused by Trypanosoma cruzi and its treatment is done only with two drugs, nifurtimox and benznidazole. However, both drugs are ineffective in the chronic phase, in addition to causing serious side effects. This context of therapeutic limitation justifies the continuous research for alternative drugs. Here, we study the in vitro trypanocidal effects of the non-steroidal anti-inflammatory drug nimesulide, a molecule that has in its chemical structure a toxicophoric ...
Tópico(s): Research on Leishmaniasis Studies
2021 - Public Library of Science | PLoS ONE
Bruno Gomes, Carla A. Sousa, María Teresa Novo, Ferdinando B. Freitas, Ricardo Ribeiro Alves, Ana R Côrte-Real, Patrícia Salgueiro, Martin J. Donnelly, Antonio P. Almeida, João Pinto,
Abstract Background Culex pipiens L. is the most widespread mosquito vector in temperate regions. This species consists of two forms, denoted molestus and pipiens, that exhibit important behavioural and physiological differences. The evolutionary relationships and taxonomic status of these forms remain unclear. In northern European latitudes molestus and pipiens populations occupy different habitats (underground vs . aboveground), a separation that most likely promotes genetic isolation between forms. ...
Tópico(s): Genetic diversity and population structure
2009 - Springer Science+Business Media | BMC Evolutionary Biology
Ricardo G. Teixeira, Ana Rita Brás, Leonor Côrte‐Real, Rajendhraprasad Tatikonda, Anabela Sanches, M. Paula Robalo, Fernando Avecilla, Tiago Moreira, M. Helena García, Matti Haukka, Ana Preto, Andreia Valente,
Three new compounds have been synthesized and completely characterized by analytical and spectroscopic techniques. The new bipyridine-perfluorinated ligand L1 and the new organometallic complex [Ru(η5-MeCp)(PPh3)2Cl] (Ru1) crystalize in the centrosymmetric triclinic space group P1¯. Analysis of the phenotypic effects induced by both organometallic complexes Ru1 and [Ru(η5-MeCp)(PPh3)(L1)][CF3SO3] (Ru2), on human colorectal cancer cells (SW480 and RKO) survival, showed that Ru2 has a potent anti-proliferative ...
Tópico(s): Ferrocene Chemistry and Applications
2017 - Elsevier BV | European Journal of Medicinal Chemistry
Ricardo M. Trigo, Timothy J. Osborn, João Corte‐Real,
CR Climate Research Contact the journal Facebook Twitter RSS Mailing List Subscribe to our mailing list via Mailchimp HomeLatest VolumeAbout the JournalEditorsSpecials CR 20:9-17 (2002) - doi:10.3354/cr020009 The North Atlantic Oscillation influence on Europe: climate impacts and associated physical mechanisms Ricardo M. Trigo1,2,*, Timothy J. Osborn1, João M. Corte-Real3 1Climatic Research Unit, University of East Anglia, Norwich NR4 7TJ, United Kingdom 2Department of Physics, and 3Institute for Applied ...
Tópico(s): Tropical and Extratropical Cyclones Research
2002 - Inter-Research Science Center | Climate Research
Produção Nacional
Revisado por pares
Denise CS Matos, Lanuza A. P. Faccioli, Léa Cysne‐Finkelstein, Paula Mello De Luca, Suzana Côrte‐Real, Geraldo R. G. Armôa, Elezer Lemes, Débora Decoté‐Ricardo, Sergio C.F. Mendonça,
Kinetoplastid membrane protein-11 (KMP-11), a protein present in all kinetoplastid protozoa, is considered a potential candidate for a leishmaniasis vaccine. A suitable leishmaniasis vaccine candidate molecule must be expressed in amastigotes, the infective stage for mammals. However, the expression of KMP-11 in Leishmania amastigotes has been a subject of controversy. We evaluated the expression of this molecule in logarithmic and stationary growth phase promastigotes, as well as in amastigotes, ...
Tópico(s): Parasites and Host Interactions
2010 - Instituto Oswaldo Cruz, Ministério da Saúde | Memórias do Instituto Oswaldo Cruz
José Carlos Pettorossi Imparato, Daniela Prócida Raggio, Clarissa Calil Bonifácio, Ricardo Scarparo Navarro, Fernanda Sardenberg, Rubens Côrte Real de Carvalho,
The aim of this study was to investigate the microleakage of pit and fissure sealants in primary teeth and to determine if multi-step methods should produce better results in terms of microleakage prevention.A total of 40 intact primary molars were randomly assigned to one of four sealant groups: resin based sealant Ultraseal XT (US - Ultradent) (Group 1, n=10); adhesive system Scotchbond Multi Purpose Plus (SBMP - 3M/ESPE) used as a sealant (Group 2, n=10); primer (SBMP) and US (Group 3, n=10); and primer, ...
Tópico(s): Endodontics and Root Canal Treatments
2009 - Jaypee Brothers | The Journal of Contemporary Dental Practice
Tiago R. Velho, Rafael Maniés Pereira, Tiago Paixão, Nuno Carvalho Guerra, Ricardo Melo Ferreira, Hugo Côrte-Real, Ângelo Nobre, Luís F. Moita,
The Sequential Organ Failure Assessment (SOFA) score is a predictor of mortality in ICU patients. Although it is widely used and has been validated as a reliable and independent predictor of mortality and morbidity in cardiac ICU, few studies correlate early postoperative SOFA with long-term survival.Retrospective observational cohort study.Tertiary academic cardiac surgery ICU.One-thousand three-hundred seventy-nine patients submitted to cardiac surgery.SOFA 24 hours, SOFA 48 hours, mean, and highest ...
Tópico(s): Mechanical Circulatory Support Devices
2022 - Wolters Kluwer | Critical Care Explorations
Sofia Fernandes, Mariana Rodrigues, C Barreiros, Hugo Côrte-Real, Ricardo Ferreira, Ângelo Nobre,
Abstract Acute aortic dissection and acute pulmonary embolism are two life-threatening emergencies. The presented case is of an 81-year-old man who has been diagnosed with an acute Stanford type A aortic dissection and referred to a tertiary hospital for surgical treatment. After a successful aortic repair and an overall favourable postoperative recovery, he was diagnosed with cervical and upper extremity deep vein thrombosis and was anticoagulated accordingly. He later presented with massive bilateral ...
Tópico(s): Aortic aneurysm repair treatments
2021 - De Gruyter Open | The Journal of Critical Care Medicine
Vítor Borges, Joana Isidro, Nídia S. Trovão, Sílvia Duarte, Helena Cortes Martins, Hugo Martiniano, Isabel Gordo, Ricardo B. Leite, Luı́s Vieira, Agostinho José S. Lira, Aida M. Sousa Fernandes, Alexandra Estrada, Alexandra Nunes, Alfredo Sotero Alves Rodrigues, Ana Castro Caldas, Ana Constança, Ana Margarida Henriques, Ana Miguel Matos, Ana Oliveira, Ana Paula Soares Dias, Ana Pelerito, Ana Rita Couto, Anabela Vilares, Antônio Albuquerque, Baltazar Nunes, Bruna R. Gouveia, Carina Rodrigues, Carla Feliciano, Carla Roque, Carlos Cardoso, Carlos Sousa, Cathy Paulino, Célia Bettencourt, Cláudia C. Branco, Cláudia Nunes dos Santos, Conceição Godinho, Constantino Caetano, Cristina Correia, Cristina Toscano, Cristina Veríssimo, Daniela Silva, Diana Patrícia Pinto da Silva, Eliana Costa, Elizabeth Pádua, Fátima Martins, Fátima Vale, Fernanda Vilarinho, Fernando Branca, Filomena Caldeira, Filomena Lacerda, Francisca Rocha, M.P.F. Graça, Helena Ribeiro, Helena Rodrigues, Herberto Jesus, Hugo Sousa, Idalina Ferreira, Inês Baldaque, Inês Costa, Inês Gomes, Inna Slobidnyk, Isabel Soares de Albergaria, Isabel Dias, Isabel Fernandes, Isabel Lopes de Carvalho, Ivone Água‐Doce, Jácome Bruges‐Armas, J M Guerra Ramos, João Carlos Sousa, João Costa, João Victor Leite Dias, João Rodrigues, João Sobral, Jorge Machado, Jorge Meneses, José Antônio Barreto Alves, José Vicente Constantino, Laura Brum, Leonor Silveira, Líbia Zé‐Zé, Lídia Santos, Ludivina Freitas, Luís Silva, Luísa Mota‐Vieira, Lurdes Lopes, Lummy Monteiro, M. T. Faria, Margarida Farinha, Margarida Vaz, M. Alice Pinto, Maria Ana Pessanha, Maria Beatriz Tomaz, Maria Calle Vellés, Maria da Graça Maciel de Soveral, Maria Helena Ramos, María Isabel Veiga, Maria João Gargaté, Maria João Peres, Maria José Borrego, Maria Matos Figueiredo, Mariana Leonel Martins, Mariana Thereza Rodrigues Viana, Maurício Melim, Miguel Babarro Jorreto, Miguel Fevereiro, Miguel Pinheiro, Mónica Oleastro, Nair Seixas, Nelson Ventura, Nuno Verdasca, O. A. Dalla Costa, Patrícia Barros, Patrícia Fonseca, Patricia Martínez‐Miguel, Maria Paula Bajanca-Lavado, Paula Branquinho, Paula Palminha, Paula Matias Soares, Paula Valente, Paulo Leandro, Paulo Pereira, Pedro Henrique Cardoso, Pedro Pechirra, Pedro Ramos, Raquel Neves, Raquel Rocha, Raquel Rodrigues, Raquel Sabino, Regina Sá, Ricardo Filipe Romão Ferreira, Ricardo Gouveia Rodrigues, Rita C. Veloso, Rita Cordeiro, Rita Côrte‐Real, Rita de Sousa, Rita Gralha, Rita Macedo, Rita Matos, Rita Rodrigues, S. Paulo, SARA MELISSA LAGO SOUSA, Sílvia Lopo, Sónia Marta Santos Magalhães, Sónia Rodrigues, Sónia Silva, Susana Ladeiro, Susana Martins, Susana Pereira Silva, Teresa Salvado, Tiago C. Luís, Valquíria Alves, Vera Manageiro, Raquel Guiomar, João Paulo Gomes,
Genomic surveillance of SARS-CoV-2 in Portugal was rapidly implemented by the National Institute of Health in the early stages of the COVID-19 epidemic, in collaboration with more than 50 laboratories distributed nationwide.By applying recent phylodynamic models that allow integration of individual-based travel history, we reconstructed and characterized the spatio-temporal dynamics of SARS-CoV-2 introductions and early dissemination in Portugal.We detected at least 277 independent SARS-CoV-2 introductions, ...
Tópico(s): Evolution and Genetic Dynamics
2022 - Nature Portfolio | Communications Medicine
Marta Pingarilho, Victor Pimentel, Mafalda Miranda, Ana Rita Silva, António Diniz, Bianca Branco Ascenção, Carmela Piñeiro, Carmo Koch, Catarina Rodrigues, Cátia Caldas, Célia Morais, Domitília Faria, Elisabete Gomes da Silva, Eugénio Teófilo, Fátima Monteiro, Fausto Roxo, Fernando Maltêz, Fernando Rodrigues, Guilhermina Gaião, Helena Ramos, Inês Costa, Isabel Germano, Joana Simões, Joaquim Oliveira, José A. Ferreira, José Poças, José Saraiva da Cunha, Jorge Soares, Júlia Henriques, Kamal Mansinho, Liliana Pedro, Maria João Aleixo, Anabela Susana de Sousa Gonçalves, Maria José Manata, Margarida Mouro, Margarida Serrado, Micaela Caixeiro, Nuno Marques, Olga Costa, Patrícia Pacheco, Paula Proença, Paulo Rodrigues, Raquel Pinho, Raquel Tavares, Ricardo Correia de Abreu, Rita Côrte‐Real, Rosário Serrão, Rui Sarmento e Castro, Sofia Nunes, Tiago de Carvalho Faria, Teresa Baptista, Maria do Rosário Oliveira Martins, Perpétua Gómes, Luís Mendão, Daniel Simões, Ana Abecasis,
To describe and analyze transmitted drug resistance (TDR) between 2014 and 2019 in newly infected patients with HIV-1 in Portugal and to characterize its transmission networks.Clinical, socioepidemiological, and risk behavior data were collected from 820 newly diagnosed patients in Portugal between September 2014 and December 2019. The sequences obtained from drug resistance testing were used for subtyping, TDR determination, and transmission cluster (TC) analyses.In Portugal, the overall prevalence ...
Tópico(s): HIV Research and Treatment
2022 - Frontiers Media | Frontiers in Microbiology
Ricardo M. Trigo, Timothy J. Osborn, João Corte‐Real,
THE IMPACT OF THE NORTH ATLANTIC OSCILLATION ON THE EUROPEAN CLIMATE AND RIVER FLOW OF THREE MAJOR IBERIAN RIVERS – The North Atlantic Oscillation (NAO) is the most dominant mode of atmospheric circulation variability over the entire Northern Hemisphere (NH) and has recently been shown to be related to climate over large regions of the NH, in particular, over the European and North American continents. Here, a multivariable analysis of the influence ofthe NAO on the climate of the North Atlantic and ...
Tópico(s): Tropical and Extratropical Cyclones Research
2012 - University of Lisbon | Finisterra
Marta Alenquer, Tiago Milheiro Silva, Onome Akpogheneta, Filipe Ferreira, Sílvia Vale-Costa, Mónica Medina-Lopes, Frederico Batista, Ana Margarida Garcia, Vasco M. Barreto, Cathy Paulino, João Costa, João Sobral, Maria Diniz-da-Costa, Susana Ladeiro, Rita Côrte‐Real, José Delgado Alves, Ricardo B. Leite, Jocelyne Demengeot, Maria João Brito, Maria João Amorim,
Background Adults are being vaccinated against SARS-CoV-2 worldwide, but the longitudinal protection of these vaccines is uncertain, given the ongoing appearance of SARS-CoV-2 variants. Children remain largely unvaccinated and are susceptible to infection, with studies reporting that they actively transmit the virus even when asymptomatic, thus affecting the community. Methods We investigated if saliva is an effective sample for detecting SARS-CoV-2 RNA and antibodies in children, and associated ...
Tópico(s): COVID-19 Clinical Research Studies
2022 - Public Library of Science | PLoS ONE
Alexandra Compagnucci, Man K. Chan, Yacine Saïdi, Tim R. Cressey, Alasdair Bamford, Yoann Riault, Alexandra Coelho, Aoife Nolan, Suwalai Chalermpantmetagul, Gabija Morkunaite, Pauline Amuge, Victor Musiime, Avy Violari, Mark F. Cotton, Adeodata Kekitiinwa, Elizabeth Kaudha, Marisa Groenewald, Afaaf Liberty, Suparat Kanjanavanit, Алла Волоха, Rosa Bologna, Noris Pavia Ruz, Luis Prieto, P Paioni, Lino Marques, Véronique Reliquet, Tim Niehues, Steven B. Welch, Deborah Ford, Carlo Giaquinto, Diana M. Gibb, Abdel G. Babiker, José Tomás Ramos-Amador, Alexandra Compagnucci, Y Saïdi, Yoann Riault, André Coelho, Claude Kouakam, Loïc Picault, Moustapha Ndiaye, Laurence Meyer, Carole Cagnot, Sophie Circosta, L Léger, S. Simanic, A. Arulananthan, Diana M. Gibb, Abdel G. Babiker, Mei Yen Chan, Deborah Ford, Fleur Hudson, Lynda Harper, Alasdair Bamford, Anna Nolan, Kaja Widuch, S. Townsend, N. Van-Looy, Li Gao, E. Little, Anna Turkova, Stella M. Fabiane, J. Calvert, James Blackstone, Karen Scott, Jamie Inshaw, Andrew Nunn, Anthony Nardone, Davide Bilardi, Tim R. Cressey, Suwalai Chalermpantmetagul, Woottichai Khamduang, Gonzague Jourdain, Nicole Ngo Giang Huong, Dujrudee Chinwong, Chalermpong Saenjum, Rukchanok Peongjakta, Pra-ornsuda Sukrakanchana, Laddawan Laomanit, Ampika Kaewbundit, Jiraporn Khamkon, Kanchana Than-in-at, C. Meeboon, Worathip Sripaoraya, Nitinart Krueduangkam, Namthip Kruenual, Warunee Khamjakkaew, Soraya Klinprung, Carlo Giaquinto, Gabija Morkunaite, Déborah Hirt, Luis Prieto, Tim Niehues, Dietmar Plonné, Constanza Morén, Telma Noguera, María Ángeles Muñoz‐Fernández, Rosa Bologna, Solange Arazi, A.G. Fedullo, Moira Taicz, E. Vicentini, Matías Moragas, Andrea Mangano, M. Dell’Orso, Mariana Gatto, Véronique Reliquet, A Soria, E. Paredes, Nathalie Chéreau, Mee-Kung Sin, Laurent Flet, Audrey Rodallec, C. Hemon, Narcisse Elenga, M.D. Terrine, Blaise Nkegoum, Salvador Augustín, P. Mespoulhe, Hugo Pouchain, Noris Pavía-Ruz, Rebeca Hernández, Angelica Neri-Macias, Ma Dolores Jarillo-Quijada, C. Espinosa-Sotero, Lino Marques, Cristina Teixeira, Alexandre Fernandes, Raquel Nunes, H. Nascimento, Joana Tuna, Andreia Padrao, Ivan Savioli Ferraz, Ana Constança Mendes, C. Correira, H.M. Pinheiro, A.C. Matos, A.C. Sampaio, Afonso Oliveira, Ana Teresa Caldeira, M. Tavares, A. Reis Melo, Carlos de Castro, Cláudia C. Faria, Carmo Prucha, Ricardo Ribeiro, Fátima Monteiro, António Candeias, T. Silva Milhiero, E. Gomes Neves, Afonso Oliveira, Rita Côrte‐Real, Micaela Morgado, Diogo Mendes, Marta Cardão, Avy Violari, Nastassja Ramsagar, Abigail Liberty, Mukesh K. Nyati, Lindiwe Maseko, Mirriam Khunene, Sibongile Mkhize, Zaynab Essack, Nazim Akoojee, Umesh Singh, Yolandie Fourie, S. Govender, Aasia Vadee, Reshma Lakha, Jeremy Erasmus, Angelous Mamiane, T M Daniel, P. Bhana, Nomfundo Maduna, Mark F. Cotton, Marizeth Groenewald, George Slade, J. F. Coetzee, Lindee Ganger, Steven M. Weldon, M. Wessels, Laura van Hoorn, Sonja Pieterse, Candice Makola, K. Smith, Michelle Isaacs, A. Cweya, Stéphanie Fry, Shaun Barnabas, Maurice Theunissen, N. Nduna, Cornelius M. Smuts, Pablo Rojo Conejo, Cristina Epalza, Luis Prieto, María Ángeles Muñoz‐Fernández, María José Mellado, Talía Sáinz Costa, L. Escosa García, Pilar Gomez Salcedo, Clàudia Fortuny Guasch, T. Noguera Julian, Carolina Estepa, M. Cubells, E. Sans, Elisa Bruno, Luis Prieto, Patricia García, A. Murciano Cabeza, Mario A. Blanco, Rosa Bou, M. Torres Arauz, M. Navarro Gómez, Antonio Mǔr, S. Guillén Martín, M Moreno, José Tomás Ramos Amador, I. Laso García, C. Kalhert, Tanja Wachinger, B. Wohlwend, S. Häfner, G Dollenmaier, P Paioni, Ruth Signorell, Joseph Boni, Andrea Duppenthaler, G. Bruce Mann, C. Saegesser, Maria Teresa Barbani, Chaiwat Ngampiyaskul, Pisut Greetanukroh, P. Khannak, Pathanee Tearsansern, Wanna Chamjamrat, Nuttawut Chanto, Thitiwat Thapwai, Khanungnit Thungkham, Patcharee Puangmalai, Chutima Ruklao, Pradthana Ounchanum, Suwimon Khusuwan, S. Denjanta, Yupawan Thaweesombat, Jutarat Thewsoongnoen, Kanyanee Kaewmamueng, Phakamas Kamboua, Supawadee Pongprapass, W. Srisuk, Areerat Kongponoi, Juthamas Limplertjareanwanich, Suparat Kanjanavanit, Chayakorn Saewtrakool, Pacharaporn Yingyong, Duangrat Chutima, Raungwit Junkaew, Thannapat Chankun, Ussanee Srirompotong, Patamawadee Sudsaard, K. Kongsuk, Turian Petpranee, Sakulrat Srirojana, D. Donngernl, A. Kamkoonmongkol, N. Na Kalasin, P. Phunkhum, A. Kekitiinwa, Pauline Amuge, Dickson Bbuye, Justine Nalubwama, Sylvia Namanda, Muzamil Nsibuka Kisekka, Anthony Kirabira, L Lawrence, Gerald Muzorah Agaba, Grace Miriam Ahimbisibwe, Annet Nalugo, Florence Namuli, Rose Jacqueline Kadhuba, Rachel Namuddu, I. Nabwire, Lameck Kiyimba, A Baita, Judith Tikabibamu, L. Nakandi, Grace P. Kisitu, N. Nabukeera Barung, Cissy Kityo, Victor Musiime, Elizabeth Kaudha, Annet Nanduudu, Emmanuel Mujyambere, S.P. Labeja Ocitti, Juliet Ategeka, E. Nambi, Rashidah Nazzinda, Diana Rutebarika,
BackgroundIntegrase inhibitor (INSTI) with boosted darunavir (DRV/r), a regimen with a high-resistance barrier, avoiding NRTI toxicities, might be a switching option in children living with HIV (CLWHIV).MethodsSMILE is a randomised non-inferiority trial evaluating safety and antiviral efficacy of once-daily INSTI + DRV/r vs. continuing on current standard-of-care (SOC) triple ART (2NRTI + boosted PI/NNRTI) in virologically-suppressed CLWHIV aged 6–18 years. The primary outcome is the proportion with confirmed ...
Elsevier BV
Ricardo Abrantes, Victor Pimentel, Mafalda Miranda, Ana Rita Silva, António Diniz, Bianca Branco Ascenção, Carmela Piñeiro, Carmo Koch, Catarina Rodrigues, Cátia Caldas, Célia Morais, Domitília Faria, Elisabete Gomes da Silva, Eugénio Teófilo, Fátima Monteiro, Fausto Roxo, Fernando Maltêz, Fernando Rodrigues, Guilhermina Gaião, Helena Ramos, Inês Costa, Isabel Germano, Joana Simões, Joaquim Oliveira, José A. Ferreira, José Poças, José Saraiva da Cunha, Jorge Soares, Sandra Bianchini Fernandes, Kamal Mansinho, Liliana Pedro, Maria João Aleixo, Maria João Gonçalves, Maria José Manata, Margarida Mouro, Margarida Serrado, Micaela Caixeiro, Nuno Marques, Olga Costa, Patrícia Pacheco, Paula Proença, Paulo Rodrigues, Raquel Pinho, Raquel Tavares, Ricardo Correia de Abreu, Rita Côrte‐Real, Rosário Serrão, Rui Sarmento e Castro, Sofia Nunes, Tiago de Carvalho Faria, Teresa Baptista, Daniel Simões, Luís Mendão, Maria do Rosário Oliveira Martins, Perpétua Gómes, Marta Pingarilho, Ana Abecasis,
Introduction HIV late presentation (LP) remains excessive in Europe. We aimed to analyze the factors associated with late presentation in the MSM population newly diagnosed with HIV in Portugal between 2014 and 2019. Methods We included 391 newly HIV-1 diagnosed Men who have Sex with Men (MSM), from the BESTHOPE project, in 17 countrywide Portuguese hospitals. The data included clinical and socio-behavioral questionnaires and the viral genomic sequence obtained in the drug resistance test before starting ...
Tópico(s): HIV Research and Treatment
2024 - Frontiers Media | Frontiers in Public Health
Joana Côrte-Real, Inês Dutra, Ricardo Rocha,
Probabilistic Inductive Logic Programming (PILP) systems extend ILP by allowing the world to be represented using probabilistic facts and rules, and by learning probabilistic theories that can be used to make predictions. However, such systems can be inefficient both due to the large search space inherited from the ILP algorithm and to the probabilistic evaluation needed whenever a new candidate theory is generated. To address the latter issue, this work introduces probability estimators aimed at ...
Tópico(s): Logic, Reasoning, and Knowledge
2017 - Springer Science+Business Media | Lecture notes in computer science
Wilson Moreira Dutra Júnior, Aloízio Soares Ferreira, Jaime Urdapilleta Tarouco, Ricardo Frederico Euclydes, Juarez Lopes Donzele, Paulo Sávio Lopes, Leandro Lunardini Cardoso,
Foram utilizadas 48 fêmeas suínas abatidas aos 50, 60, 70, 80, 90, 100, 110 e 120 kg para determinar os rendimentos de cortes comerciais e de carne magra na carcaça, visando-se estimar área de olho de lombo (AOL) e espessura de toucinho (ET), utilizando-se a técnica de ultra-sonografia em tempo real. Foram tomadas medidas ultra-sônicas in vivo, para AOL e ET; nas carcaças quentes, utilizou-se equipamento óptico da marca Hennessy, a fim de estimar a ET e profundidade de músculo (PM). As equações para ...
Tópico(s): Genetic and phenotypic traits in livestock
2001 - Sociedade Brasileira de Zootecnia | Revista Brasileira de Zootecnia
Produção Nacional
Revisado por pares
Ricardo Augusto Mendonça Vieira, Artur José Cabral, Paulo Marcelo de Souza, Alberto Magno Fernandes, Douglas Sampaio Henrique, Gabriela Soares Carvalho Pamplona Corte Real,
Two dairy goat systems conducted according to the household model were evaluated in terms of income generation. An enterprise budget analysis was performed using data collected from August, 2004, to July, 2005. Farms named A and B were smallholdings and raised Saanem goats intensively. Herd indexes, incomes, taxes, fuel, energy, concentrates, opportunity costs and interest in capital were computed. Net present value and internal rate of return were estimated to appreciate the business appeal in ...
Tópico(s): Genetic and phenotypic traits in livestock
2009 - Sociedade Brasileira de Zootecnia | Revista Brasileira de Zootecnia
Ana Côrte-Real, Rita P. Ribeiro, Ricardo Machado, Ana Mafalda Silva, Tiago Nunes,
While clinical dentistry has seamlessly integrated the digital revolution, there is a gap in the technological capabilities of forensic dentistry.The study aimed to compare the superimposition accuracy of two different three-dimensional record formats, namely the intraoral scanner and cone beam computer tomography, in the context of forensic identification.The sample consisted of randomly selected adults (n=10) of both sexes aged between 20 and 50 years. Following the acquisition of data using the ...
Tópico(s): Autopsy Techniques and Outcomes
2024 - Elsevier BV | Forensic Science International
Produção Nacional
Revisado por pares
Patrícia Valente Araújo, Jeane de Fátima Correia‐Silva, Ricardo Santiago Gomez, Maria de Lourdes de Andrade Massara, María Esperanza Cortés, Luiz Thadeu de Abreu Poletto,
The aim of this study was to evaluate the antimicrobial effect of photodynamic therapy (PDT) in carious lesions in vivo by culture and real-time PCR methods. Ten teeth with deep active carious lesions were selected and five portions of carious dentin were removed for each tooth. Two increments were used as control, to represent the superficial and deep dentin, respectively. Methylene blue at 100 mg/L was placed in contact with the cavity for 5 min, before being irradiated with a halogen light source ...
Tópico(s): Biosensors and Analytical Detection
2015 - Elsevier BV | Photodiagnosis and Photodynamic Therapy
P Freitas, Ana Rita Santos, A Ferreira, Afonso Oliveira, Mariana Gonçalves, Ana Corte-Real, Catarina Lameiras, Joana Maurício, Énia Ornelas, Clara Matos, Daniel Faria, João B. Augusto, Joana Sobrinho Simões, Inês Ferreira, Ana Pedroso, Ana Coutinho Santos, Miguel Nuno da Silva Gomes Rodrigues Gago, João Diogo Oliveira, Ricardo Mamede Antunes, David Campos Correia, Ana Lynce, João Brito, Carlos Aguíar, Jorge Ferreira, Carlos Morais, Luís Campos, Luís Raposo, Miguel Mendes,
Identifying patients with normotensive pulmonary embolism (PE) who may benefit from thrombolysis remains challenging. We sought to develop and validate a score to predict 30-days PE-related mortality and/or rescue thrombolysis.We retrospectively assessed 554 patients with normotensive PE. Independent predictors of the studied endpoint were identified from variables available at admission in the emergency department and were used to create a score. The model was validated in 308 patients from a separate ...
Tópico(s): Acute Ischemic Stroke Management
2018 - Elsevier BV | International Journal of Cardiology
Rodrigo Saraiva, Beatriz Côrte‐Real, Catarina Cordeiro, Maria João Gonçalves, M. Abreu, Ricardo Coentre,
Tópico(s): Schizophrenia research and treatment
2023 - | The Primary Care Companion For CNS Disorders
Joana Côrte-Real, Inês Dutra, Ricardo Rocha,
Medical data is particularly interesting as a subject for relational data mining due to the complex interactions which exist between different entities. Furthermore, the ambiguity of medical imaging causes interpretation to be complex and error-prone, and thus particularly amenable to improvement through automated decision support. Probabilistic Inductive Logic Programming (PILP) is a particularly well-suited tool for this task, since it makes it possible to combine the relational nature of this ...
Tópico(s): Data Mining Algorithms and Applications
2018 - Springer Science+Business Media | Lecture notes in computer science
Joana P. Guedes, Tiago Cardoso, Ticiana Fernandes, Filipa Mendes, Margarida Baleiras-Couto, Filomena L. Duarte, Maria João Sousa, Ricardo Franco‐Duarte, Susana R. Chaves, Manuela Côrte‐Real,
Wine is widely consumed throughout the world and represents a significant financial market, but production faces increasing challenges. While consumers progressively value more complex flavor profiles, regional authenticity, and decreased use of additives, winemakers strive for consistency among climate change, characterized by rising environmental temperatures and sun burn events. This often leads to grapes reaching phenolic maturity with higher sugar levels, and increased microbial spoilage risk. ...
Tópico(s): Wine Industry and Tourism
2024 - Elsevier BV | Heliyon
Pedro Adão, Maria da Luz Calado, Wilson Fernandes, Luís G. Alves, Leonor Côrte‐Real, M. Guedes, Ricardo Baptista, Raul Bernardino, Maria M. Gil, Maria Jorge Campos, Susana Bernardino,
The use of processed limestone sludge as a crosslinking agent for films based on Na–alginate and ɩ-carrageenan/Na-alginate blends was studied. Sorbitol was tested as a plasticizer. The produced gel formulations included alginate/sorbitol and carrageenan/alginate/sorbitol mixtures, with tested sorbitol concentrations of 0.0, 0.5 and 1.0 wt%. The limestone sludge waste obtained from the processing of quarried limestone was converted into an aqueous solution of Ca2+ by dissolution with mineral acid. ...
Tópico(s): Marine and coastal plant biology
2024 - Multidisciplinary Digital Publishing Institute | Materials
João Vasco Côrte‐Real, Ana M. Lopes, Hugo Rebelo, João Paulo Lopes, Francisco Amorim, Ricardo Pita, Jorge Correia, Pedro Melo, Pedro Beja, Pedro J. Esteves, Joana Abrantes,
Adenoviruses (AdV) are pathogens capable of infecting animals and humans leading to a wide spectrum of diseases. They have a widespread geographical dissemination and infect several species, including red squirrels (Sciurus vulgaris). In the Iberian Peninsula, there are no reports of infection of red squirrels by AdV. In this study, we report for the first time the detection of squirrel AdV in a red squirrel trapped in central Portugal. The phylogenetic analysis showed that the sequences obtained ...
Tópico(s): Animal Virus Infections Studies
2020 - Wiley | Transboundary and Emerging Diseases