Tânia Costa, Inês Linhares, Ricardo B. Ferreira, Jasmin Neves, Adelaide Almeida,
Aims: The present study aims to evaluate the predominance of uropathogens responsible for urinary tract infection (UTI) and determine their resistance patterns, to assess if the recommended empirical treatment is appropriate for the studied population. Samples were collected in Aveiro (Portugal) from an ambulatory service between June 2011 and June 2014. Results: From the 4,270 positive urine samples for UTI, 3,561 (83%) were from women and only 709 (17%) were from men. The bacterium Escherichia coli ...
Tópico(s): Kidney Stones and Urolithiasis Treatments
2018 - Mary Ann Liebert, Inc. | Microbial Drug Resistance
Diana Linhares, Ricardo Camarinho, Patrícia Garcia, Armindo Rodrigues,
Fluoride is often found in elevated concentrations in volcanic areas due to the release of magmatic fluorine as hydrogen fluorine through volcanic degassing. The exposure to high levels of fluoride can affect the processes of bone formation and resorption causing skeletal fluorosis, a pathology that can easily be mistaken for other skeletal diseases. In this study, we aimed to determine if fluoride concentration in the femoral bone of wild populations of the house mouse (Mus musculus) is a good biomarker ...
Tópico(s): Mercury impact and mitigation studies
2018 - Elsevier BV | Chemosphere
Produção Nacional
Revisado por pares
Carla Pauli, Marcelo Libório Schwarzbold, Alexandre Paim Díaz, Maria Emília Rodrigues de Oliveira Thais, Charles Kondageski, Marcelo Neves Linhares, Ricardo Guarnieri, Bianca de Lemos Zingano, Juliana Ben, Jean Costa Nunes, Hans J. Markowitsch, Peter Wolf, Samuel Wiebe, Kátia Lin, Roger Walz,
To investigate prospectively the independent predictors of a minimum clinically important change (MCIC) in quality of life (QOL) after anterior temporal lobectomy (ATL) for drug-resistant mesial temporal lobe epilepsy related to hippocampal sclerosis (MTLE-HS) in Brazilian patients.Multiple binary logistic regression analysis was performed to identify the clinical, demographic, radiologic, and electrophysiologic variables independently associated with MCIC in the Quality of Life in Epilepsy-31 Inventory ( ...
Tópico(s): Neuroscience and Neuropharmacology Research
2017 - Wiley | Epilepsia
Produção Nacional
Revisado por pares
Carlos Araújo da Costa, Karen Cristini Yumi Ogawa Furtado, Louise de Souza Canto Ferreira, Danilo de Souza Almeida, Alexandre da Costa Linhares, Ricardo Ishak, Antônio Carlos Rosário Vallinoto, José Alexandre Rodrigues de Lemos, Luisa Carício Martins, Edna Aoba Yassui Ishikawa, Rita Catarina Medeiros Sousa, Maísa Silva de Sousa,
Background HTLV-1 is a retrovirus that causes lymphoproliferative disorders and inflammatory and degenerative diseases of the central nervous system in humans. The prevalence of this infection is high in parts of Brazil and there is a general lack of public health care programs. As a consequence, official data on the transmission routes of this virus are scarce. Objective To demonstrate familial aggregation of HTLV infections in the metropolitan region of Belém, Pará, Brazil. Method A cross-sectional ...
Tópico(s): Vector-Borne Animal Diseases
2013 - Public Library of Science | PLoS neglected tropical diseases
Produção Nacional
Revisado por pares
Alexandre Paim Díaz, Marcelo Libório Schwarzbold, Maria Emília Rodrigues de Oliveira Thais, Alexandre Hohl, Melina Moré Bertotti, Roseli Schmoeller, Jean Costa Nunes, Rui Daniel Prediger, Marcelo Neves Linhares, Ricardo Guarnieri, Roger Walz,
Traumatic brain injury (TBI) is a major cause of death and disability and impairs health-related quality of life (HRQOL). Psychiatric disorders have been recognized as major components of TBI morbidity, yet few studies have addressed the relationship between these outcomes. Sample size, selection bias, and retrospective design, are methodological limitations for TBI-related psychiatric studies. For this study, 33 patients with severe TBI were evaluated prospectively regarding demographic, clinical, ...
Tópico(s): Cardiac Arrest and Resuscitation
2011 - Mary Ann Liebert, Inc. | Journal of Neurotrauma
Laura Aguiar Torres, Armindo Rodrigues, Diana Linhares, Ricardo Camarinho, Zelia Rego, Patrícia Garcia,
We have evaluated buccal epithelial cell micronucleus formation as a biomarker of genotoxic damage following occupational exposure to low doses of ionizing radiation. Buccal epithelial cells were collected from 42 occupationally exposed medical personnel and 39 non-exposed individuals (reference group). Each individual in the exposed group was routinely monitored with a personal radiation badge. The frequency of micronucleated cells (MNC) was significantly higher in the exposed group (5.26 vs. 1.33 ...
Tópico(s): Effects of Radiation Exposure
2018 - Elsevier BV | Mutation Research/Genetic Toxicology and Environmental Mutagenesis
Produção Nacional
Revisado por pares
Ricardo Linhares Sampaio, Flávio Dutra de Resende, Ricardo Andrade Reis, Ivanna Moraes de Oliveira, Letícia Custódio, Rodolfo Maciel Fernandes, Raul Dirceu Pazdiora, Gustavo Rezende Siqueira,
This study evaluated the nutritional interrelationship between the growing and finishing phases of crossbred cattle in determining their performance. One hundred and eight animals were used (8 months old, body weight [BW] 211 ± 20 kg). During the dry season, the animals received one of the following supplements: a mineral plus urea supplement (ad libitum, MSD), a protein supplement (1 g/kg BW per day, PR1), or a protein-energy supplement (5 g/kg BW per day, PE). During the rainy season, the animals received ...
Tópico(s): Animal Nutrition and Physiology
2017 - Springer Science+Business Media | Tropical Animal Health and Production
Produção Nacional
Revisado por pares
André Mateus Valentim Alvim, Roberto Ventura Santos, Martín Roddaz, Pierre‐Olivier Antoine, María Inés Feijó Ramos, Dermeval Aparecido do Carmo, Ana Paula Linhares, Francisco Ricardo Negri,
Several studies have reported Miocene shallow-marine incursions in the Pebas Megawetland system (Western Amazonia) based on paleontological and sedimentological evidence. Only a few publications restricted to Middle and Late Miocene fossils outcropping in the Iquitos (Peru), Benjamin Constant and Eirunepé (Brazil) areas have provided isotopic evidence to test these incursions. In this study, we present new carbon, oxygen, and strontium (87Sr/86Sr ratios) isotopic data of macrofossils (pacu and ray teeth, ...
Tópico(s): Geology and Paleoclimatology Research
2021 - Elsevier BV | Palaeogeography Palaeoclimatology Palaeoecology
Produção Nacional
Revisado por pares
Helena M. B. Veiga, Luciana Boher e Souza, Felipe P. Fleming, Ivan Ibanez, Ricardo Linhares, Angela O. Nieckele, L. F. A. Azevedo,
Detailed local and averaged measurements of wax deposition in an annular pipe section were conducted and combined with a comprehensive simulation model. The objective of the study was to contribute to the understanding of the fundamental mechanisms responsible for wax deposition on surfaces. To this end, a laboratory-scale annular deposition section was designed to offer well-defined boundary and initial conditions for the deposition experiments. The test section allowed visual access to the deposit ...
Tópico(s): Hydrocarbon exploration and reservoir analysis
2020 - American Chemical Society | Energy & Fuels
Produção Nacional
Revisado por pares
Raul Dirceu Pazdiora, Flávio Dutra de Resende, Marcelo Henrique de Faria, Gustavo Rezende Siqueira, Geraldo Benedito de Souza Almeida, Ricardo Linhares Sampaio, Paulo Santana Pacheco, Murilo Sergio Rodrigues Prietto,
The objective of this study was to evaluate animal performance and carcass characteristics of 64 Nellore young bulls at 22 months of age finished in a feedlot and slaughtered at five body weights (350; 455; 485; 555 and 580 kg) fed diets containing coated or uncoated urea. The experimental design adopted was completely randomized, set in a 4 × 2 factorial arrangement, and for the variables assessed in the control animals, it was 5 × 2. No effect of interaction between slaughter weights and diets were ...
Tópico(s): Genetic and phenotypic traits in livestock
2013 - Sociedade Brasileira de Zootecnia | Revista Brasileira de Zootecnia
Produção Nacional
Revisado por pares
Kívia Linhares Ferrazzo, Ricardo Alves Mesquita, ATT Aburad, Fábio Daumas Nunes, SOM De Sousa,
Plasmablastic lymphoma (PBL) of the oral cavity is an aggressive neoplasm derived from B cell, considered to be the second more common among human immunodeficiency virus (HIV)-associated malignancies. As Epstein-Barr virus (EBV) infection has been associated with this neoplasm, the aim of the present study was to assess the presence of EBV in 11 cases of oral HIV-related PBL and investigate the controversial issue of the presence of Human herpesvirus-8 (HHV-8) in these tumors.DNA was extracted from ...
Tópico(s): Parvovirus B19 Infection Studies
2007 - Wiley | Oral Diseases
Produção Nacional
Revisado por pares
Gilson Camargo Tibo, Sebastião de Campos Valadares Filho, José Fernando Coelho da Silva, Rilene Ferreira Diniz Valadares, Maria Ignêz Leão, Paulo Roberto Cecon, Ricardo Linhares Sampaio,
Foram avaliados os efeitos dos níveis de concentrado nas rações sobre a eficiência de síntese microbiana, o balanço de compostos nitrogenados, a concentração de amônia e o pH do fluido ruminal, a taxa de passagem da digesta ruminal e as perdas endógenas de compostos nitrogenados (N). Foram utilizados cinco novilhos F1 Simental x Nelore, não-castrados, fistulados no rúmen, abomaso e íleo, alimentados à vontade com dietas que continham 25,0; 37,5; 50,0; 62,5; e 75,0% de concentrado e distribuídos em ...
Tópico(s): Ruminant Nutrition and Digestive Physiology
2000 - Sociedade Brasileira de Zootecnia | Revista Brasileira de Zootecnia
Produção Nacional
Revisado por pares
Márcio Machado Ladeira, Sebastião de Campos Valadares Filho, José Fernando Coelho da Silva, Maria Ignêz Leão, Ricardo Linhares Sampaio,
O objetivo deste experimento foi avaliar os efeitos dos níveis de concentrado das dietas sobre os consumos e as digestibilidades aparentes totais e parciais de matéria seca (MS), matéria orgânica (MO), proteína bruta (PB), extrato etéreo (EE), fibra em detergente neutro (FDN) e carboidratos totais (CHO). O efeito das coletas realizadas durante o dia e a noite, para as digestibilidades aparentes totais e parciais da MS e MO, também foi avaliado. Quatro novilhos Nelore, não-castrados, fistulados no rúmen, ...
Tópico(s): Sunflower and Safflower Cultivation
1999 - Sociedade Brasileira de Zootecnia | Revista Brasileira de Zootecnia
Produção Nacional
Revisado por pares
Rogério Marchiori Coan, Ricardo Andrade Reis, Flávio Dutra de Resende, Ricardo Linhares Sampaio, R. P. Schocken-Iturrino, Gisela Rojas Garcia, Telma Teresinha Berchielli,
O experimento foi conduzido com o objetivo de avaliar o desempenho, as características de carcaça e a viabilidade econômica do confinamento de bovinos alimentados com silagem dos capins tanzânia ou marandu, com 0 e 10% de polpa cítrica peletizada (PCP), em comparação à silagem de milho. Foram utilizados silos de superfície (12 × 5 × 1 m) como silos experimentais. O delineamento experimental utilizado foi o inteiramente casualizado, com oito tratamentos (dietas) e seis repetições (animais). As dietas experimentais ...
Tópico(s): Genetic and phenotypic traits in livestock
2008 - Sociedade Brasileira de Zootecnia | Revista Brasileira de Zootecnia
Produção Nacional
Revisado por pares
Flávio Henrique Silveira Rabêlo, Salete Aparecida Gaziola, Mônica Lanzoni Rossi, Neidiquele M. Silveira, Małgorzata Wójcik, Andrzej Bajguz, Alicja Piotrowska‐Niczyporuk, José Lavres, Francisco Scaglia Linhares, Ricardo Antunes Azevedo, Jaco Vangronsveld, Luís Reynaldo Ferracciú Alleoni,
We evaluated the mechanisms that control Cd accumulation and distribution, and the mechanisms that protect the photosynthetic apparatus of Brachiaria decumbens Stapf. cv. Basilisk and Panicum maximum Jacq. cv. Massai from Cd-induced oxidative stress, as well as the effects of simulated summer or winter conditions on these mechanisms. Both grasses were grown in unpolluted and Cd-polluted Oxisol (0.63 and 3.6 mg Cd kg−1 soil, respectively) at summer and winter conditions. Grasses grown in the Cd-polluted ...
Tópico(s): Plant responses to water stress
2020 - Wiley | Physiologia Plantarum
Produção Nacional
Revisado por pares
Daniel Alexandre, Ricardo T. Linhares, Bruna Barros de Queiroz, Luisa Fontoura, Adriana Ferreira Uchôa, Richard Ian Samuels, Maria Lı́gia Rodrigues Macedo, Cezar S. Bezerra, Eliana M. Oliveira, Diogo Ribeiro Demartini, Célia R. Carlini, Carlos P. Silva,
The fate of vicilins ingested by Callosobruchus maculatus and the physiological importance of these proteins in larvae and adults have been recently investigated. Vicilins have been demonstrated to be absorbed through the midgut epithelium, circulate in their trimeric form in the haemolymph and are deposited in the fat body. In fat body cells of both sexes, vicilins are partially hydrolyzed and the fragments are eventually deposited in the eggs. Tracking the fate of FITC-labelled vicilins in adult ...
Tópico(s): Insect and Pesticide Research
2011 - Elsevier BV | Journal of Insect Physiology
Produção Nacional
Revisado por pares
Sheila Mendonça de Souza, Adriana Ferreira Uchôa, José Roberto da Silva, Richard Ian Samuels, Antônia Elenir Amâncio Oliveira, Eliana M. Oliveira, Ricardo T. Linhares, Daniel Alexandre, Carlos P. Silva,
The fate of vicilins ingested by Callosobruchus maculatus and the physiological importance of these proteins in larvae and adults were investigated. Vicilins were quantified by ELISA in the haemolymph and fat body during larval development (2nd to 4th instars), in pupae and adults, as well as in ovaries and eggs. Western blot analysis demonstrated that the majority of absorbed vicilins were degraded in the fat body. Tracing the fate of vicilins using FITC revealed that the FITC-vicilin complex was ...
Tópico(s): Insect Utilization and Effects
2010 - Elsevier BV | Journal of Insect Physiology
Produção Nacional
Revisado por pares
Selma H. Sasaki, Rosa Elisa Carvalho Linhares, Carlos Nozawa, Ricardo Montalván, Luzia Doretto Paccola-Meirelles,
Four Lentinula edodes strains (Le10, 46, K2, Assai) were assessed for their antagonistic effect on four filamentous fungus species of agricultural importance (Helminthosporium euphorbiae, Helminthosporium sp, Fusarium solani and Phomopsis sojae) and on Alagoas serotype of Vesicular Stomatitis Virus (VSA). The L. edodes strains studied had variable effects on the filamentous fungi and on VSA. The K2 and Le10 strains were antagonistic on the fungi assessed and the 46 and K2 strains were efficient on ...
Tópico(s): Phytochemical compounds biological activities
2001 - Springer Nature | Brazilian Journal of Microbiology
Produção Nacional
Revisado por pares
Luciana Navajás Rennó, Rilene Ferreira Diniz Valadares, Sebastião de Campos Valadares Filho, Maria Ignêz Leão, José Fernando Coelho da Silva, Paulo Roberto Cecon, L.C. Gonçalves, Helder Luiz Chaves Dias, Ricardo Sampaio Linhares,
O trabalho foi conduzido com os objetivos de determinar a concentração plasmática de N-uréia (NUP), a excreção fracional de uréia (EFU) e as excreções de uréia (EU) e creatinina (EC), para várias condições experimentais; estabelecer a relação entre NUP, excreção fracional de uréia e excreção de uréia com a porcentagem de proteína bruta (PB) e fibra em detergente neutro (FDN) da dieta; e avaliar as perdas urinárias endógenas, por meio da determinação da excreção de creatinina. Nos experimentos I e II, ...
Tópico(s): Diet and metabolism studies
2000 - Sociedade Brasileira de Zootecnia | Revista Brasileira de Zootecnia
Joana Vieira de Castro, Céline S. Gonçalves, Sandra Costa, Paulo Linhares, Ruí Vaz, Ricardo Nabiço, Júlia Amorim, Marta Viana‐Pereira, Rui Manuel Reis, Bruno M. Costa,
Transforming growth factor beta (TGF-β) plays an important role in carcinogenesis. Two polymorphisms in the TGF-β1 gene (-509C/T and 869T/C) were described to influence susceptibility to gastric and breast cancers. The 869T/C polymorphism was also associated with overall survival in breast cancer patients. In the present study, we investigated the relevance of these TGF-β1 polymorphism in glioma risk and prognosis. A case-control study that included 114 glioma patients and 138 cancer-free controls ...
Tópico(s): Glioma Diagnosis and Treatment
2015 - SAGE Publishing | Tumor Biology
Produção Nacional
Revisado por pares
Felipe Favoretto Furlan, Lucélia Borgo, Flávio Henrique Silveira Rabêlo, Mônica Lanzoni Rossi, Francisco Scaglia Linhares, Adriana Pinheiro Martinelli, Ricardo Antunes Azevedo, José Lavres,
Previous studies have unraveled contrasting Al genotypic differences between Urochloa brizantha cv. Marandu (moderately tolerant) and Urochloa brizantha cv. Xaraés (more tolerant). Our objective was to evaluate differences in the response to Al-induced stress between these genotypes, focusing on Al compartmentation in the root apoplast and symplast, and antioxidant enzyme activities after Al exposure. Al-accumulation was 25% higher in the roots of cv. Xaraés than cv. Marandu, while in the shoot Al ...
Tópico(s): Silicon Effects in Agriculture
2019 - Elsevier BV | Chemosphere
Produção Nacional
Rodrigo de Queiroz Lemes, Paulo Cesar da Silva Filho, Paulo Ricardo Linhares Souza, Laércio Wanderley dos Santos,
O objetivo deste estudo foi avaliar a influência de métodos de superação de dormência na germinação e desenvolvimento de mudas de jatobá (Hymenaea courbaril L.) em diferentes substratos. O delineamento experimental utilizado na superação da dormência de sementes foi o inteiramente casualizado, com quatro repetições de vinte e cinco sementes na parcela. Os métodos de superação de dormência utilizados foram: sementes sem escarificação (M1); sementes escarificadas no lado do eixo embrionário (M2) sementes ...
Tópico(s): Seed Germination and Physiology
2023 - | UNICIÊNCIAS
Produção Nacional
Revisado por pares
Bruno Lima Linhares, Eduardo Miranda, A. R. S. Cintra, Ricardo Reges, Luiz Otávio Torres,
For several decades, testosterone and its synthetic derivatives have been used for anabolic and androgenic purposes. Initially restricted to professional bodybuilders, these substances gradually became more popular with recreational weightlifters. Considering its increasing prevalence, the consumption of anabolic androgenic steroids (AAS) has become a matter of great concern. Although most side effects are mild and reversible, some of them can cause permanent damage or can be potentially life threatening. ...
Tópico(s): Doping in Sports
2021 - Elsevier BV | Sexual Medicine Reviews
Produção Nacional
Revisado por pares
Cristiane Ribeiro de Carvalho, Mark William Lopes, Leandra C. Constantino, Alexandre Ademar Hoeller, Hiago Murilo Melo, Ricardo Guarnieri, Marcelo Neves Linhares, Zuner A. Bortolotto, Rui Daniel Prediger, Alexandra Latini, Kátia Lin, Júlio Licinio, Rodrigo Bainy Leal, Roger Walz,
We demonstrate that the rate of extracellular signal-related kinase phosphorylation (P-ERK1,2/Total-ERK1,2) in the amygdala is negatively and independently associated with anxiety symptoms in 23 consecutive patients with drug-resistant mesial temporal lobe epilepsy that was surgically treated. In naive Wistar rats, the P-ERK1,2/Total-ERK1,2 ratio in the amygdala correlates negatively with innate anxiety-related behavior on the elevated plus maze (n = 20) but positively with expression of defensive-learned ...
Tópico(s): Receptor Mechanisms and Signaling
2021 - Springer Nature | Molecular Psychiatry
Produção Nacional
Revisado por pares
Ricardo Kerschbaumer, Robson R. Linhares, Jean Marcelo Simão, Paulo Cézar Stadzisz, Carlos R. Erig Lima,
The growing demand for high-performance digital circuits, mainly involving FPGAs, increases the demand for high-level synthesis (HLS) tools. Traditional Hardware Description Languages (HDLs) are complex and depend on low-level abstractions, thereby requiring hardware detailed knowledge from developers. In turn, the current HLS tools are based on proprietary or C/C[Formula: see text] derived languages, which allow easier circuit description but decrease performance. This work presents an alternative ...
Tópico(s): Radiation Effects in Electronics
2017 - World Scientific | Journal of Circuits Systems and Computers
Produção Nacional
Revisado por pares
Marcelo Libório Schwarzbold, Alexandre Paim Díaz, Jean Costa Nunes, Daniel Santos Sousa, Alexandre Hohl, Ricardo Guarnieri, Marcelo Neves Linhares, Roger Walz,
Objective: To evaluate the validity and utility of the Hamilton Rating Scale for Depression (HAM-D), Beck Depression Inventory (BDI), and Hospital Anxiety and Depression Scale (HADS) as screening tools for depression after severe traumatic brain injury (TBI). Methods: Forty-six consecutive survivors of severe TBI were evaluated at a median of 15 months after injury. Receiver operating characteristic (ROC) analysis was performed using HAM-D, BDI, and HADS as predictors, and the Structured Clinical Interview ...
Tópico(s): Traumatic Brain Injury and Neurovascular Disturbances
2014 - Associação Brasileira de Psiquiatria | Brazilian Journal of Psychiatry
Produção Nacional
Revisado por pares
Alexandre Paim Díaz, Marcelo Libório Schwarzbold, Maria Emília de Oliveira Thais, G Cavallazzi, Roseli Schmoeller, Jean Costa Nunes, Alexandre Hohl, Ricardo Guarnieri, Marcelo Neves Linhares, Roger Walz,
To evaluate predictors of non-return to work (nRTW) among social, demographic, clinical, and psychiatric variables after severe traumatic brain injury (TBI) in a cohort of Brazilian patients.Prospective study. Forty-three community-dwelling individuals treated at a Level I trauma center at the time of TBI were evaluated 18 months after trauma. Measures included DSM-IV-TR criteria for personality changes after TBI and Structured Clinical Interview for DSM-IV Axis I Disorders (SCID-I) to assess psychiatric ...
Tópico(s): Traumatic Brain Injury and Neurovascular Disturbances
2014 - Associação Brasileira de Psiquiatria | Brazilian Journal of Psychiatry
Produção Nacional
Revisado por pares
Nayara Lopes, Lígia Carla Faccin‐Galhardi, Samantha Fernandes Espada, Arcelina Cunha Pacheco, Nágila Maria Pontes Silva Ricardo, Rosa Elisa Carvalho Linhares, Carlos Nozawa,
Herpes simplex virus (HSV) is one of the most regular human pathogens, being a public health problem, and causal agent of several diseases. Poliovirus (PV) is an enteric virus and about 1% of infected individuals develop paralytic poliomyelitis due to viral invasion of the central nervous system and destruction of motor neurons. This work evaluated the activity of a sulfated polysaccharide of Caesalpinia ferrea (SPLCf) in HSV and PV replication. The antiviral effect of SPLCf at varying concentrations ...
Tópico(s): Molecular Biology Techniques and Applications
2013 - Elsevier BV | International Journal of Biological Macromolecules
Produção Nacional
Revisado por pares
Ricardo Ishak, A. C. Linhares, M.O.G. Ishak,
The occurrence of laboratory-acquired infections have elicited in the last ten years an intense interest in methods and procedures for the safe handling of microbiological material. The major laboratory safety problem is aerial transmission, however, protection against airborne hazards is efficiently achieved by the use of microbiological safety cabinets. Biosafety rules should be strictly followed by all members of a laboratory. Evaluation of these procedures should be effectively performed by ...
Tópico(s): Biotechnology and Related Fields
1989 - UNIVERSIDADE DE SÃO PAULO | Revista do Instituto de Medicina Tropical de São Paulo
Nuno Menezes, Ricardo Lima, Ana Sofia Linhares Moreira, Paulo Varela, Ana Barroso, Armando Baptista, Bárbara Parente,
Erlotinib and cetuximab are human epidermal growth factor receptor inhibitors (EGFRI) that are approved in monotherapy for the treatment of patients with locally advanced or metastatic non-small cell lung cancer after failure of at least one prior chemotherapy regimen. Papulopustular eruptions are the most frequent adverse effect, their occurrence being associated with increased survival in some studies. We describe 19 patients who presented with a rash located mainly to the face and trunk, without ...
Tópico(s): Chronic Lymphocytic Leukemia Research
2009 - John Libbey Eurotext | European Journal of Dermatology