Jonathan Northcroft, Waldemar Januszczak, Mary Briad, Hala Jaber, John Dugdale, John Gerritsen, Oliver Chestney, Barbara Hall, Fred Redwood, Jon Swain, Moira Hughes, Tessa Mayes, Helen Davies, Nicholas Rufford, Peter Whittle, Rob Hughes, Andrew Winter, John Peter, Sally Brock, Colin Brennan, Marian Hussenbux, Jim Munro football editor, Katie Samuel, Andrew Longmore, Clare Gascolgne, Lesley White, Robin Eggar, Sally Kinnes, Maggie Forbes-Buckingham, Tim Nagle, Margaret Brown, Frank Whitford, Steve Davis, Terence Blacker, Kathryn Cooper, David Smith, Carmiola lonescu, Tim Richards, Humphrey Carpenter, Helen Davis, Steven Poole, David Cracknell Political Editor, Nick Pitt, Neil Wormald, John O'Byrne, Andrew Sullivan, Henry Kroto, Clive Davis, Sally Kinnea, Stephen Grey, Ken MacDonal, Simon Wilde, Anthony Sattin, David Hutchson, Evan McHugh, Robert Winnett, Nilgin Yusuf, Irwin Stelzer, Adrian Furnham, Al Murray, Peter Wilson, Can Davis, David Dougill, Christine Lamb, Poppy Simpson, Malcolm Glazier, Professor Gideson Garter, Barbara Baker, Joan May, Alan Rhodes, Geraldine Hackett, Jasper Jerard, David Hewson, Alistair Weaver, Anne Enright, Mangal Kapoor, Cally Law, Hugh Canning, Hugh Mcllvanney, Ozge Ibrahim, Jeremy Clarkson, Victoria Segal, Mark 'Haggler' Hodson, Peter Conradi, David Cairns, Clare Gascoigne, Edward Porter, Michael Portillo, Peter Kemp, Patricia Nicol, Sarah Dempster, Dave Pollard, Richard Need, Richard Fletcher, Greg Struthers, Roland Whitte, Lydia Slater, Derren Hayes, Tony Muddimer, Mark Crivelli, Jeremy Guscott, Tahir Ishaque, David Walsh Chief Sports Writer, Mike Laws, Robin Scott-Elliot, Askold Krushel-nycky, Sarah-Kate Templeton, Roger Eglin, Paul Donovan, Mark Espiner, Adam Nathan Defence Correspondent, Paul Kimmage, Paul Driver, Richard Dawkins, Nicholas Hellen, John Follain, Sally Jones, Ian Hawkey, Shelley Von Strunckel, Christopher Morgan, David Leppard, Paul Durman, Richard Girling, Dominic Prince, Mark Edwards, Rachel Bridge, Sarah Gracie, Jonathan Paul, Kira Cochrane, Paul Sexton, Rosalind Esche, S M, Partricia Nicol, Christina Lamb, Wendy Lewis, Lois Rogers, Sean Newsom, Ken Gregory, Harry Thomson, Raymond Keene, Paul Brown, Gareth Huw Davies, Rod Liddle, David Cracknell, Cosmo Landesman, Zoe Brennan, Richard Chatten, Stephen Jones, Dominic O'Connell, Blower Spindle, Louise Armitstead, Uzi Mahnaimi, Nick Cain, Michael Wright, Adrienne Connors, Casmo Landesman, Natalie Graham, Caroline Donald, Sir Michael Quinlan, Ian Sumner, Caroline Gascoigne, Colin McDowell, Robert Ballantyne, Stephen Armstrong, John Elliott, Ray Gilpin, Russell Miller, Mark Anstead, Tony Rocca, Antony Sattin, Roland White, Shane Watson, Abul Taher, Richard Brooks Arts Editor, Maggie Parker, Richard Rae, Mark Franchetti, Ray Hutton, Karen Tunn, Jon Ungoed-Thomas, Augusten Burroughs, Louise Armistead, Jonathan Leake, Naomi Wolf, Michael Sheridan, Clare Francis, Amanda Craig, John Harlow, Dileep Premachandran, Barry Collins, John Waples, A A Gill, Michael Edwards, Tom Robbins, Lois Wilson, Stephen Pettitt, Will Iredale, Jonathan Leake Science Editor, Jessica Bown, Ian Wilson, Rosemary Leach, Jane Mulkerins, Jeremy Langmead, David Cameron, Geraidine Hackett Education Correspondent, Lord Goldsmith, Colin Blair, Justin Sparks, Rajiv Radhakrishnan, David Wickers, J W Ward, Roger Dobson, Daniel Emery, Brian Doogan, R B J T Allenby, John Aizlewood, Jeremy Lazell, James Knight, Mark Hodson, Andrew Frankel, Graham Norwood, Joe Lovejoy, Jonathan Futrell, Amanda Bllnkhorn, Gwen Strauss, David Budworth, Hugh Pearman, Andrew Davidson, Tony Perrottet, Kent Allen, Patricia Gallagher, Mike Hammond, David Smith Economics Editor, Rachel De Thame, J T Leroy, Damlan Wild, Sarah Baxter, Joanna Simon, Matthew Goodman, Sir Roger Bannister, Vanessa Wilde, John Inman, Jason Dawe, Shayla Walmsley, Richard Lewis, Sian Griffiths, Karen Robinson, Helen Stewart,
... Carpenter Alex Will in the World by Stephen Greenblatt Top five Philip and Elizabeth by Gyles Brandreth ... A Tale of Fell-running and Obsession by Richard Askwith Aurum £16.99 Bestsellers 2004 Basil D' ...
2004 - Gale Group | Sunday Times HA GDA
... Organizational Behavior in Chinese Society, by Sidney L. Greenblatt, Richard W. Wilson and Amy A. Wilson Get access ... Behavior in Chinese Society edited by Sidney L. Greenblatt, Richard W. Wilson, and Amy A. Wilson. New York, ...
Tópico(s): China's Socioeconomic Reforms and Governance
1981 - Oxford University Press | Political Science Quarterly
John Chapman, Jonathan Northcroft, Waldemar Januszczak, John Dugdale, Hala Jaber, Phillip McGuinness, Amrit Dhillion, B P, Helena Frith Powell, Nigel Botherway, Gail Emms, Ventia Dearden, Shaznay Lewis, Victoria Gray, Jim Munro, Christopher Croft, Paula Radcliffe, Helen Davies, Sally Brock, Nicholas Rufford, Andrea Lieberman, Jason Dawe, John Peter, Pam Barrett, Amanda Ursell, Lesley White, Jane Mulkerrins, Christopher Somerville, Walter Ablett, Peter Day, Gareth Walsh, Frank Whitford, B W, Kathryn Cooper, P D, Tim Richards, Steven Poole, Nick Pitt, Des Kelly, Neil Wormald, E P, H Hamilton, Alison Kervin, Andrew Sullivan, Clive Davis, Nyree Lewis, Joseph Dunn, Tony Allen-Mills, Pen Hadow, Martin James, Ariel Leve, Tom Walker, Robert Winnett, J Carey, Dipesh Gadher Transport Correspondent, Irwin Stelzer, Adrian Furnham, Tom English, Al Murray, Peter Wilson, Rosie Millard, Robert Hewison, David Dougill, John Arlidge, Ian De'Ath, Alan Titchmarsh, Adrian Fumham, Bill Arthur, John Dugdak, Harold McGraw, Rob Maul, David Hewson, John Dixon, Cally Law, Hugh Canning, Hugh Mcllvanney, Lucy Rouse, Peter Watson, Jeremy Clarkson, Gareth Chadwick, Edward Porter, David Cairns, Anthony Odell, Shirely Robertson, Ben Kimber, Michael Portillo, Stewart Lee, Victoria Segal, Patricia Nicol, Sarah Dempster, Kelly Holmes, Christopher Price, Sidney Brichto, S J Durham, Richard Fletcher, Paul Johnson, Alex James, Peter Oliver, Lydia Slater, Patrick Maxwell, Andrew Porter Deputy Political Editor, Minette Martin, Jeremy Guscott, Andrew Thomas, Mark Stapleton, Brendan Bourne, David Walsh Chief Sports Writer, Paul Abdale, Christopher Silvester, Stuart Wavell, Roger Eglin, John Keegan, Pam Ward, Paul Donovan, Edward Gorman, Vincent Crump, Giles Hattersley, Paul Kimmage, Chris Woodhead, Piers Paul Read, Martin Wyness, Jasper Gerard, Richard Dawkins, Michael Woodhead, Garth Pearce, John Humphrys, Ray Ward, Nicholas Hellen, John Follain, Sally Jones, Paul Driver, Ian Hawkey, Ralph Tuck, Michael Barone, Christopher Morgan, David Leppard, Bert Wright, Peter Freedman, Paul Durman, Alex Clark, Lisa Grainger, Tom Tom Go, Michael Winterbottom, Mark Edwards, Darius Sanai, Rachel Bridge, Maureen Martella, Stephen Clarke, Jane Bussman, Karen Stupples, Martin Ternouth, Christopher Hope, Roland Lovell, Nerina Shute, Phil Baker, Tony Rossiter, Raymond Keene, C L, Rod Liddle, Professor Gidean Garter, A R Somerset, Cosmo Landesman, kevin Dunp, Zoe Brennan, Catherine Turner, Diana Wright, Jack O'sullivan, Tim Congdon, Emma Smith, Helen Hawkins, Stephen Jones, Dominic O'Connell, Stephen Bleach, Louise Armitstead, Nick Cain, Robert Frank, Michael Wright, Caroline Scott, Adrienne Connors, Natalie Graham, Tim Moorey, Louise Armitead, Victoria Cleary, Caroline Donald, Susan Clarke, Miranda Seymour, David Walsh, Jeremy Paxman, Helen Brown, Sir Tom Finney, Andrew White, Stephen Armstrong, John Elliott, Fergus Dowding, James Simspon-Daniel, Victoria O'brien, Roland White, Jane Wallsworth, Michael Sheriden, Shane Watson, Abul Taher, Miriam Stoppard, Ronald White, Richard Brooks Arts Editor, Stewart Milne, Mark Franchetti, Stephen Jones Sports Journalist, Ray Hutton, Jon Ungoed-Thomas, Ria Higgins, Huw Richards, Jonathan Leake, Brendan Simms, M E, John P McCarthy, Ivon Caplin, Mike Tindall, D J Taylor, Margaret Walters, John Harlow, Dileep Premachandran, Brian Smyth, Hamish Brown, Shaun Payne, John Waples, Gareth Jenkins, Jeremy Hart, David Parsons, Ros Dodd, Matthew Campbell, Brian Glanville, John Carey, Pirkko Wallis, Stephen Pettitt, Deirdre Fernand, Jonathan Carr-Brown, Will Iredale, Jessica Bown, David Bray, Gareth Davies, Jeremy Langmead, R H, Joseph McGoran, Sally Kinnes, Colin McDOWELL'S, Naomi Caine, Nigel Powell, David Wickers, Michael Bright, Daniel Emery, Hugh McMANNERS, Peter Almond, Brian Doogan, Sophie Harrison, Ben Dowell, Peter Schmeichel, John Aizlewood, David Bedford, Mark Hodson, Graham Norwood, Andrew Frankel, James Knight, Joe Lovejoy, David Gellatly, John Cornwell, David Guterson, David Budworth, Grand Slam, Hugh Pearman, Dan Cairns, Shelley Von Strunckel, Alex Marshall, Alan Parker, Stewart Mitchell, Mike Hammond, Tom Deveson, Rodney Smith, Rachel De Thame, Professor Robert Weale, Danny Plunkett, Sarah Baxter, Brian Schofield, Isabel Newstead, Douglas Kennedy, Jim Muir, Matthew Goodman, Joanna Simon, Fiona Henderson, Simon Howard, Ed Hughes, Barry Newcombe, Dominic Rushe, Richard Lewis, Karen Robinson, Helen Stewart,
... the World: How Shakespeare Became Shakespeare by Stephen Greenblatt Cape £20 pp430 Read in More Comfort Views ...
2004 - Gale Group | Sunday Times HA GDA
Darrell R. Abernethy, David J. Greenblatt, Richard I. Shader,
... R. ABERNETHY, M.D., Ph.D., DAVID J. GREENBLATT, M.D., RICHARD I. SHADER, M.D.DARRELL R. ABERNETHY, M. ... for more papers by this author, DAVID J. GREENBLATT, M.D.Search for more papers by this author, RICHARD I. SHADER, M.D.Search for more papers ...
Tópico(s): Electroconvulsive Therapy Studies
1981 - American College of Physicians | Annals of Internal Medicine
By George Clark Political Correspondent, By Our Political Correspondent, By A Staff Reporter, By Christopher Thomas Labour Reporter, By Maurice Corina Industrial Editor, By Our Parliamentary Staff, By Our Social Services Correspondent, From Our Correspondent, By Peter Evans Home Affairs Correspondent, By a Staff Reporter, By Ian Bradley, By Our Music Reporter, By Donald Macintyre Labour Reporter, From Ronald Kershaw, By Pearce Wright Science Editor, By Kenneth Gosling, By Peter Hill Industrial Correspondent, By John Young Planning Reporter, From Charles Hargrove, From Our Own Correspondent, From Nicholas Ashford, From Mario Modiano, By Richard Harris, From David Cross, From Frederick Cleary, From Jean-Pierre Gallois of Agence France-Presse, From Michael Knipe, From Patricia Clough, by Lord Drogheda, Philip Venning, David Robinson, DAVID WADE, Sheridan Morley, Martin Huckerby, Joan Chissell, Paul Griffiths, Thomas Walker, Geraldine Norman, Pamela Vandyke Price, Roy Hay, Ion Trewin, Harry Golombek, Edward Mayer, Marcel Berlins, Sheila Black, Fred Emery, Anthony Howard, John Groser, Robert Robinson, RICHARD WORCESTER, , W. E. BAUGH, , MICHAEL HAVERS, , JACOBSON, , KEITH KYLE, , G. SCHWARZENBERGER, , T. O. THOMAS, , R. M. ROBBINS, , DROGHEDA, , AUSTEN ALBU, , HENRY HOBHOUSE, , D. M. RAMSAY, , VIVIEN STERN, , NACRO, , MARTIN WRIGHT, , CHRIS ANDREWS, , MURRAY BRUGGEN, , B. W. MILLINGTON, , W. W. INGE, , C. P. T. WALLIS, , R. ALTSHUL, , CLIVE J. ALLEN, , Paul Oestreicher, By Barry J. Kemp, , By Huon Mallalieu, Dr N. L. Rabinovitch writes:, Sir Wilton Lee writes:, By Richard Allen and Christopher Wilkins, By Derek Harris, By Caroline Atkinson, By Patricia Tisdall Management Correspondent, By Donald Macintyre, By Kenneth Owen Technology Correspondent, By Our Commercial Editor, By Desmond Quigley Company News Editor, By Our Economics Staff, By Our Banking Correspondent, By Bryan Appleyard, John Drummond, Roger Beard, John Whitmore, Peter Wainwright, Sally Michael, By Michael Clark, By Ray Maughan, By Michael Phillips Racing Correspondent, From Mitchell Platts, By John Woodcock Cricket Correspondent, By Pamela Macgregor-Morris,
... to challenger, Joint lead in Silk chess, Chess Greenblatt gambit, ENO chorus ends strike, Weekend broadcasting Tv ...
1978 - Gale Group | TDA
Produção Nacional
Revisado por pares
Antônio Egídio Nardi, Fiammetta Cosci, Richard Balon, Steven J. Weintraub, Rafael C. Freire, John H. Krystal, Thomas Roth, Edward Silberman, Nicoletta Sonino, Giovanni A. Fava, Vladan Starčević, Steven Dubovsky, Carl Salzman, Karl Rickels, David J. Greenblatt, Richard I. Shader, Guy Chouinard,
... L. MD; Salzman, Carl MD; Rickels, Karl MD; Greenblatt, David J. MD; Shader, Richard I. MD; Chouinard, Guy MD; The International Task ...
Tópico(s): Sleep and related disorders
2018 - Lippincott Williams & Wilkins | Journal of Clinical Psychopharmacology
Alex Finer, Terry Delaney, Richard Buckle, John Fryer, Jon Swain, Harold Hobson, Alan Gibson, Rob Hughes, John Lambert, Graham Rose, Antony Terry, Lars Persson, Ronald Blythe, Diane Fisher, John Whale, Julian Symons, Frederic Raphael, Jason Tomas, Philip Oakes, John Russell, Richard Milner, Brian James, Deryk Brown, (Miss) V. R. Viazzanl, Philip Clarke, Derek Jewell, Vivian Jenkins, Peter Watson, Norman Harris, David Blundy, Peter Hain, Timothy Johnson, Elakn Allan, Robert Troop, Malcolm Crawford Economics Editor, Roger Eglin, Woodrow Wyatt, Lorana Sullivan, John Ball, Mortimer Wheeler, Michael Wpods, Maxwell Boyd, D. K. O. Ullmann, Tony Geraghty, John Fryer Labour Correspondent, Nicholas Carroll, L. Raynaud General Manager, John Hopkins, Spike Millgan, Denis Herbstein, Bryan Silcock, Roger Mortimer, Eric Jacobs, Reverend Basll Tudor Guy Bishop of Gloucester, Peter Hall, Elaine Potter, Gwen Nuttall, John Bell, William Ellsworth-Jones, Jean Robertson, Ronald Butt, Dilys Powell, Tony Rocca, Elkan Allan, Phllip Clarke, Clive Everton, Hugo Young, Dudley Doust, Felix Aprahamian, Ian Jack, Margaret Costa, C. H. O'd Alexander, James Margach Political Correspondent, Jeremy Roundall, Tony Crook, Hunter Davies, Tony Dawe, Michael Moynihan, Brian Glanville, Keith Richardson, Jun Ryotai, A G H Brousson, Graham Searjeant, Peter Dunn, Ivan Robinson, Michael Roberts, George Steiner, Michael Green, Maurice Wiggin, Roman Eisenstein, Dennis Pringle, Hans Keller, Malcolm Crawford, Vincent Hanna, Inigo Jones,
... Renaissance Man and his Roles by Stephen J Greenblatt/Yale University Press £2.95 Sir Walter Ralegh ...
1973 - Gale Group | Sunday Times HA GDA
David J. Greenblatt, Richard I. Shader, Jerold S. Harmatz,
... David J. Greenblatt MD, Corresponding Author David J. Greenblatt MD Division of Clinical Pharmacology, Departments of Psychiatry, Medicine, and Pharmacology, Tufts University School of Medicine and New England Medical Center, Boston.Division of Clinical Pharmacology, Box 1007, Tufts-New England Medical Center, 171 Harrison Avenue, Boston, MA 02111.Search for more papers by this authorRichard I. Shader MD, Richard I. Shader MD Division of Clinical Pharmacology, Departments ... David J. Greenblatt MD, Corresponding Author David J. Greenblatt MD Division of Clinical Pharmacology, Departments of Psychiatry, Medicine, and Pharmacology, Tufts University School of Medicine and New England Medical Center, Boston.Division of Clinical Pharmacology, Box 1007, Tufts-New England Medical Center, 171 Harrison Avenue, Boston, MA 02111.Search for more papers by this authorRichard I. Shader MD, Richard I. Shader MD Division of Clinical Pharmacology, Departments ...
Tópico(s): Schizophrenia research and treatment
1989 - Wiley | The Journal of Clinical Pharmacology
Lawrence G. Miller, David J. Greenblatt, Richard I. Shader,
... this authorDavid J. Greenblatt, Corresponding Author David J. Greenblatt Division of Clinical Pharmacology, Departments of Psychiatry and Medicine, Tufts University School of Medicine and New England Medical Center, Boston, MA, 02111 U.S.A.Division of Clinical Pharmacology, Departments of Psychiatry and Medicine, Tufts University School of Medicine and New England Medical Center, Boston, MA., 02111 U.S.A.Search for more papers by this authorRichard I. Shader, Richard I. Shader Division of Clinical Pharmacology, Departments of ...
Tópico(s): Synthesis and pharmacology of benzodiazepine derivatives
1987 - Wiley | Biopharmaceutics & Drug Disposition
David J. Greenblatt, Richard I. Shader,
The history of the tranquilizer meprobamate illustrates how factors other than scientific evidence may determine physicians' patterns of drug use. Forceful advertising and publicity, an attitude of general optimism, and uncontrolled studies with favorable results combined to elevate meprobamate to the position of America's magical cure-all tranquilizer. This drug remains in wide use despite a large body of sound scientific data that questions its efficacy. Today easy pharmacologic solutions to the ...
Tópico(s): Psychedelics and Drug Studies
1971 - American Psychiatric Association | American Journal of Psychiatry
David J. Greenblatt, Richard I. Shader, S. M. MacLeod, Edward M. Sellers, Käte Franke, H. G. Giles,
Tópico(s): Poisoning and overdose treatments
1978 - Springer Science+Business Media | European Journal of Clinical Pharmacology
David J. Greenblatt, Richard I. Shader,
(1978). Dependence, Tolerance, and Addiction to Benzodiazepines: Clinical and Pharmacokinetic Considerations. Drug Metabolism Reviews: Vol. 8, No. 1, pp. 13-28.
Tópico(s): Pharmaceutical studies and practices
1978 - Taylor & Francis | Drug Metabolism Reviews
David J. Greenblatt, Richard I. Shader, Stuart MacLeod, Edward M. Sellers,
Tópico(s): Pharmacogenetics and Drug Metabolism
1978 - Adis, Springer Healthcare | Clinical Pharmacokinetics
David J. Greenblatt, Richard I. Shader, Daniel R. Weinberger, Marcia D. Allen, Dean S. MacLaughlin,
Tópico(s): Attention Deficit Hyperactivity Disorder
1978 - Springer Science+Business Media | Psychopharmacology
Jan Koch‐Weser, David J. Greenblatt, Richard I. Shader,
THE neuropharmacologic properties of the many benzodiazepine derivatives available for clinical use are qualitatively similar if not identical.1 , 2 Nonetheless, new benzodiazepines continue to be marketed and promoted as "unique" agents for the treatment of anxiety or insomnia.3 Thus, there is a need for critical comparative assessment of new benzodiazepine derivatives as they are introduced to clinical use. This article assesses the properties and apparent clinical value of prazepam and lorazepam ( ...
Tópico(s): Sleep and Wakefulness Research
1978 - Massachusetts Medical Society | New England Journal of Medicine
David J. Greenblatt, Richard I. Shader,
Tópico(s): Pharmacological Effects and Toxicity Studies
1978 - Lippincott Williams & Wilkins | Southern Medical Journal
David J. Greenblatt, Richard I. Shader, Käte Franke, Dean S. MacLaughlin, Bernard J. Ransil, Jan Koch Weser,
Fourteen healthy subjects (7 male and 7 female) received 50 mg of chlordiazepoxide (CDX) hydrochloride by I‐hr intravenous infusion. Multiple venous blood samples drawn during the 72 hr after the infusion were assayed for whole blood concentrations of CDX and of its major metabolite, desmethylchlordiazepoxide (DMCDX). Mean (±SE) pharmacokinetic parameters, determined by weighted nonlinear least‐squares regression analysis, were: distribution half‐life, 1.3 (±0.3) hr; elimination half‐life, 17.8 (±2 .2) hr; ...
Tópico(s): Pharmacogenetics and Drug Metabolism
1977 - Wiley | Clinical Pharmacology & Therapeutics
D J Greenblatt, Richard I. Shader, J S Harmatz, Käte Franke, Jan Koch‐Weser,
Ten healthy male volunteers received chlordiazepoxide (CDX) hydrochloride or matching placebo with Maalox or water in a four-way single-dose crossover trial. Coadministration of CDX with Maalox did not change the completeness of CDX absorption but significantly slowed its rate of absorption and the rate of desmethylchlordiazepoxide (DMCDX) appearance. Self-rating of feeling "spacey" at 1.0 and 2.5 hours were significantly increased over baseline for CDX taken with water but not with Maalox. Increases ...
Tópico(s): Neuroscience and Neuropharmacology Research
1977 - American Psychiatric Association | American Journal of Psychiatry
David J. Greenblatt, Richard I. Shader, Jerold S. Harmatz, Käte Franke, Jan Koch‐Weser,
Ten healthy male subjects ingested 25 mg of chlordiazepoxide hydrochloride (Librium) with 100 ml of water or with 100 ml of magnesium and aluminum hydroxide (Maalox) in a single‐dose crossover study. Multiple venous blood samples drawn during the first 24 hr after each dose were assayed for concentrations of chlordiazepoxide and its major metabolite, desmethylchlordiazepoxide. The antacid prolonged the mean chlordiazepoxide absorption half‐time from 11 to 24 min, and in 6 of 10 subjects delayed achievement ...
Tópico(s): Chemical Synthesis and Reactions
1976 - Wiley | Clinical Pharmacology & Therapeutics
Matthew Greenblatt, Richard D. Budson,
Tópico(s): Geriatric Care and Nursing Homes
1976 - American Psychiatric Association | American Journal of Psychiatry
David J. Greenblatt, Richard I. Shader, Jan Koch‐Weser,
Serum creatine phosphokinase (CPK) concentrations were determined in healthy volunteers for the first 48 hours after intramuscular injection of 50 mg chlordiazepoxide hydrochloride or of its solvent alone. Intramuscular injection of both the drug solution and its solvent was painful and caused CPK elevations. The CPK rise due to the drug solution was 33 per cent higher than that due to the solvent alone, but the difference was not significant. The pH of the solvent preparation is low and it contains ...
Tópico(s): Cancer Treatment and Pharmacology
1976 - Wiley | The Journal of Clinical Pharmacology
David J. Greenblatt, Richard I. Shader, Jan Koch‐Weser,
Flurazepam (Dalmane, Ro 5‐6901) was introduced in 1970 in the United States as an hypnotic. Its popularity has increased rapidly. In 1973 more than 6.5 million prescriptions for flurazepam were filled at American retail pharmacies, at a total expenditure exceeding 8 million dollars.
Tópico(s): Attention Deficit Hyperactivity Disorder
1975 - Wiley | Clinical Pharmacology & Therapeutics
David J. Greenblatt, Richard I. Shader, Jan Koch‐Weser, Käte Franke,
CHLORDIAZEPOXIDE hydrochloride is commonly administered by intramuscular injection when rapid sedation is needed.1 2 3 We have observed that large doses of intramuscular chlordiazepoxide appear at ...
Tópico(s): Analytical Methods in Pharmaceuticals
1974 - Massachusetts Medical Society | New England Journal of Medicine
David J. Greenblatt, Richard I. Shader,
Treatment of AnxietyNeurotic anxiety is by far the most common indication for benzodiazepines. In a three-month period, approximately one in 10 American adults will take diazepam because of tension or nervousness. Symptomatic anxiety is extremely common among the adult population, but whether it is severe or prevalent enough to justify this extent of pharmacotherapy is questionable.Anxiety is an elusive clinical syndrome. It describes a psychophysiologic response resembling fear but inappropriate ...
Tópico(s): Circadian rhythm and melatonin
1974 - Massachusetts Medical Society | New England Journal of Medicine
David J. Greenblatt, Richard I. Shader,
Physicians staffing emergency treatment facilities seldom are required to make hasty judgments regarding pharmacotherapy of drug abuse. Unnecessary morbidity frequently results from the use of barbiturates and major tranquilizers in the emergency room. The need for sedatives and tranquilizers should be carefully assessed before they are administered. Drug-induced agitation or panic will often subside spontaneously or in response to reassurance, obviating the need for coadministration of sedatives.
Tópico(s): Intensive Care Unit Cognitive Disorders
1974 - American Psychiatric Association | American Journal of Psychiatry
David J. Greenblatt, Richard I. Shader,
DERIVATIVES of the 1,4-benzodiazepine nucleus (Fig. 1) are among the most widely used drugs in clinical medicine. In 1972 more than 77 million prescriptions for benzodiazepine antianxiety agents were filled in American retail pharmacies, of which two thirds were for diazepam. Another four million prescriptions were filled for flurazepam, a hypnotic agent. The total expenditure exceeded 200 million dollars. Benzodiazepines also are extensively administered to hospitalized patients. In two Boston teaching ...
Tópico(s): Epilepsy research and treatment
1974 - Massachusetts Medical Society | New England Journal of Medicine
Samuel H. Greenblatt, Richard L. Saunders, Charles M. Culver, W. Bogdanowicz,
• During the removal of a ruptured arteriovenous malformation, a young man underwent partial sectioning of the splenium of the corpus callosum. Postoperative testing showed no deficit of interhemispheric visual or auditory transfer. To understand the extent of the splenial section, we cut ten normal brains in the sagittal plane and analyzed the shape of the splenium. It may be markedly curved or bulbous. Our findings lead us to conclude that a small band of ventral splenial fibers may be adequate to allow ...
Tópico(s): Drug-Induced Ocular Toxicity
1980 - American Medical Association | Archives of Neurology
David J. Greenblatt, Richard I. Shader,
Tópico(s): Anesthesia and Sedative Agents
1973 - Massachusetts Medical Society | New England Journal of Medicine
David J. Greenblatt, Richard I. Shader, Jerold S. Harmatz, Anastasios Georgotas,
Tópico(s): Neural and Behavioral Psychology Studies
1979 - Springer Science+Business Media | Psychopharmacology
David J. Greenblatt, Richard I. Shader, Käte Franke, Dean S. MacLaughlin, Jerold S. Harmatz, Marcia D. Allen, Ann Werner, Elaine Woo,
Six healthy volunteers received single 2- and 4-mg doses of lorazepam by 5-min intravenous infusion, in tablet form by mouth in the fasting state, and by deltoid intramuscular injection in a six-way crossover study. A seventh subject received the 4-mg iv, po, and im doses. Concentrations of lorazepam and its glucuronide metabolite in multiple plasma samples and in all urine collected during 72 hr after each dose were determined by electron-capture GLC. Mean kinetic variables for intravenous lorazepam ...
Tópico(s): Neurotransmitter Receptor Influence on Behavior
1979 - Elsevier BV | Journal of Pharmaceutical Sciences