Leena Alhonen‐Hongisto, Richard M. Fagerstrom, Riku Laine, Hannu Elo, Juhani Jänne,
Three bis(guanylhydrazones) (those of methylglyoxal, glyoxal and ethylglyoxal) were compared for their affinity for the putative polyamine carrier and for their cellular retention in L1210 mouse leukaemia cells. All the bis(guanylhydrazones) inhibited equally effectively the uptake of spermidine by the tumour cells, indicating that the compounds had roughly equal affinity for the polyamine carrier. The fact that methylglyoxal bis(guanylhydrazone) and glyoxal bis(guanylhydrazone) were much more effectively ...
Tópico(s): RNA Interference and Gene Delivery
1984 - Portland Press | Biochemical Journal
2004 - | Social Justice A Journal of Crime Conflict & World Order
Pauli Seppänen, Richard M. Fagerstrom, Leena Alhonen‐Hongisto, Hannu Elo, Paavo Lumme, Juhani Jänne,
Glyoxal bis(guanylhydrazone), the parent compound of methylglyoxal bis(guanylhydrazone), was synthesized and tested for its ability to inhibit the biosynthesis of polyamines. It was found to be a powerful competitive inhibitor of adenosylmethionine decarboxylase (EC 4.1.1.50), yet the lack of the methyl group at the glyoxal portion increased the apparent Ki value for the enzyme by about 30-fold in comparison with methylglyoxal bis(guanylhydrazone). Glyoxal bis(guanylhydrazone) inhibited diamine oxidase ( ...
Tópico(s): Aldose Reductase and Taurine
1984 - Portland Press | Biochemical Journal
Manuj Yadav, Jungsoo Kim, Valtteri Hongisto, Densil Cabrera, Richard de Dear,
Tópico(s): Sustainable Building Design and Assessment
2025 - Acoustical Society of America | The Journal of the Acoustical Society of America
Shiva Akbarzadeh, Hong Ji, David F. Frecklington, Nelly Marmy-Conus, Yee‐Foong Mok, Leanne Bowes, Lisa Devereux, Martha E. Linsenmeyer, Richard J. Simpson, Donna S. Dorow,
... 64: 1-12PubMed Google Scholar, 9Coffey E.T. Hongisto V. Dickens M. Davis R.J. Courtney M. ...
Tópico(s): Protein Kinase Regulation and GTPase Signaling
2002 - Elsevier BV | Journal of Biological Chemistry
Junichi Fukuchi, Richard A. Hiipakka, John M. Kokontis, Kazuhiro Nishimura, Kazuei Igarashi, Shutsung Liao,
... method of Seppanen et al. (22Seppanen P. Alhonen-Hongisto L. Poso H. Janne J. FEBS Lett. 1980; ...
Tópico(s): Pancreatic function and diabetes
2004 - Elsevier BV | Journal of Biological Chemistry