(Mrs) P M Dines, Jeremy Rundall, Calman, Caroline Conran, Geoffrey Grigson, R. Bultitude, Alfred Morris Mp, Charles Raw, Dr Christopher Evans, Richard Buckle, James Margach, Richard Milner City Editor, Harold Hobson, Tom Naisby, John Lambert, Magnus Linklater, Elizabeth Gough-Cooper, Kenneth Pearson, Percy Gourgey, Graham Rose, Philip Day, Antony Terry, Nicholas Lloyd, Julian Symons, K N Strange, Cal McCrystal, Paddy Kitchen, Graham Searjeant City Reporter, H. Pinner, Doris W. Hann, John Russell, David Divine, Max Marquis, Hugh Wynn, Lord Gladwyn, Philip Clarke, Derek Jewell, Roger Lewis City Reporter, A Shalom, Vivian Jenkins, Godfrey Smith Editor, Douglas Jay, Neville K. Upton, Frank Giles, Jean Kittermaster, (Mrs) E E Newell, Karl Meyer, Cyril Connolly, Malcolm Crawford Economics Editor, George Gardiner, (Miss) Margaret Jervis, Robin Turton, Henry Sporborg Chairman, Paul Williams Chairman, John Ball, Boris Schapiro, C G Jacobs, Maxwell Boyd, Eric Chou, Tony Geraghty, Thomas J Corbin, Nicholas Carroll, Andrew Hale, Anthony Storr, Meriel McCooey asst. editor, Oscar Turnill, Derrik Mercer, Denis Herbstein, (Mrs) D M Mitchell, Peter Wilsher, John Lampard, Roger Mortimer, Eric Jacobs, Malcolm Winton, Robert Owen, Charles Raw Editor, John Raymond, Richard Garrick, Terry Burns, Desmond Shawe-Taylor, Peter Bessell, Sandy Boler, Gwen Nuttall, Norah F. Smith, Michael Bateman, Ronald Legge, Stephen Fay Labour Correspondent, Clive Irving, Alexander Mitchell, Lanning Roper, William Osler, Dilys Powell, Jean Robertson, Juan de Onis, John Lovesey, Michael Rand art director, Peter Wilsher Editor, Arthur Blood, A. S. Byatt, Richard Hughes, David Wiggins, S Goldenberg, Timothy Johnson Technology Correspondent, D A J Ripley, Roger Lewis, Robin Sanders, Ian Nairn, Jack Fingleton, David Leitch, Arnold Field, Henry Longhurst, Stephen Fay, Dr Alfred Byrne Medical Correspondent, James Margach Political Correspondent, Derek Humphry, Michael Moynihan, Brian Glanville, (Mrs) Wendie Crampton, Derek Wilson, Graham Searjeant, Maurice A. Pelter, Colin Chapman, George Steiner, C. H. O'd. Alexander, George Schwartz, Raymond Brooks-Ward, Maurice Wiggin, Atticus, Tony Clifton, Michael Parkinson, Jacquetta Hawkes, Jane Killigrew, Harlow Unger, Brenda Jones, Neil Marten, Malcolm Crawford, Muriel Bowen, Nicholas Tomalin,
... warns of student time-bomb Saigon fears mar Tet holiday Nixon may call Biafra arms halt Health ... addressed to the Sunday Standard Telephones & Cables Ltd. Rio Tinto-Zinc Corporation Limited Multiple Display Advertising Items ...
1969 - Gale Group | Sunday Times HA GDA
This article studies the lithic industry of the Early Palaeolithic from the terraces of the Roussillon, in the S of France. The geomorphological revision of the flood levels allows these industries to be related to the geochronology of the terraces which were formed in between the late Early Pleistocene and the Middle Pleistocene, and thus allows a regional chrono-cultural framework to be established. By analyzing the technology of the lithic industry derived from the concept of chaîne opératoire ...
2014 - Ediciones Universidad de Salamanca | Zephyrvs
Victor Louis, Geoffrey Grigson, Charles Raw, Richard Buckle, Oliver Stanley, Alan McElwain, Richard Milner City Editor, Alan Lee Williams, Harold Hobson, Edmund Crispin, Ellsworth Jones, John Lambert, Magnus Linklater, Graham Rose, Antony Terry, (Mrs) S. C. (Alix) Pigott, Roger Lewis City Reporters, L. E. Winterbottom, Philip Oakes, Henry Brandon, Vivian Lewis, John Russell, Richard Milner, Thomas O'Toole, David Divine, (Mrs) Pansy Headley, Ted Willis, Andrew Robertson, Edwin Morgan, Joseph Smiley, (Mrs) A. J. Shaw, Max Marquis, Timothy Giles, Joan Bateman, Murphy Steinberg, Philip Clarke, Derek Jewell, Patrick Campbell, Vivian Jenkins, Norman Harris, A V Dwyer, Neville K. Upton, Frank Giles, Robin Marlar, E. J. Toft, Brian Moynahan, Malcolm Crawford Economics Editor, Norman St John-Stevas, Jilly Cooper, Raymond Mortimer, Boris Schapiro, Maxwell Boyd, David Burg, Judith Jackson, Arthur Palmer Williams, Andrew Hale, Robert Hughes, Nicholas Evans, Geoffrey Sumner, D Ashton, Arthur Grey, Denis Herbstein, Peter Cranmer, Arnold Gregory, John Whitley, Roger Mortimer, Eric Jacobs, Anthony Greayer, Malcolm Winton, Adrian Parker, Ernestine Carter, Barbara Northcliffe MacDonald, Richard Garrick, Desmond Shawe-Taylor, Ann Frazer-Lunn, Sandy Boler, Gwen Nuttall, Stephen Aris, Margaret Bradley, Alexander Mitchell, Jean Robertson, Lanning Roper, Ronald Butt, Dilys Powell, John Lovesey, John Braine, Richard Hughes, William Rees-Mogg, David Wiggins, Timothy Johnson Technology Correspondent, Robin Sanders, Roger Lewis, Michael Field, Felix Aprahamian, Ian Nairn, Norman Lewis, Arnold Field, Graham Searjeant City Reporters, C. H. O'd Alexander, Henry Longhurst, David A Thornton, Dr Alfred Byrne Medical Correspondent, Peter Pringle, Evelyn Forbes, James Margach Political Correspondent, Derek Humphry, Brian Glanville, Michael Moynihan, Tony Dawe, Peter Hazelhurst, Lucia van der Post, Graham Searjeant, Michael Green, Maurice Wiggin, Nicholas Faith, Bob Millard, Tony Clifton, James Henderson, Harlow Unger, Charles Raw Financial Editor, Neville Maxwell, Nicholas Tomalin,
... ignore French plan The family Than gathers for Tet and trusts to luck in the Year of ... Carrington and Dewhurst Group Company United Bakeries Limited Rio Tinto-Zinc Mowlem Multiple Display Advertising Items Matthew ...
1969 - Gale Group | Sunday Times HA GDA
Kinndle Blanco‐Peña, Fernando Esperón, Ana María Torres-Mejía, Ana de la Torre, Elba de la Cruz, Mauricio Jiménez-Soto,
... qnr S, sul I, sul II , tet (A), tet (Q), van A) in the faeces of 141 pigeons from four urban parks in Alajuela, Guadalupe, Tres Ríos and San José in Costa Rica. The genes were identified by real‐time PCR directly from enema samples. About 30% of the samples were positive for genes cat I and sul I; between 13% and 17% were positive for qnr S, sul II , tet (A) and tet (Q); and 4% were positive ...
Tópico(s): Insect and Pesticide Research
2017 - Wiley | Zoonoses and Public Health
Srikumar Sen, Boxing Correspondent, James Landale, Phil Yates, Arthur Leathley, Transport Correspondent, Raymond Snoddy Media Editor, David Adams, Edward Owen, Fred Redwood, Brian Brinkworth, Gerald Vinestock, Grace Bradberry, Ian G. Templeton, Cathie Bell, Paul Ravenscroft, Neil Curry, Gavin Lumsden, Philip Delves, Philip Howard, Laurence Houseman, Michael Binyon, Joanna Bale, James Bone, George Sivell, Oliver Holt Football Correspondent, Christine Buckley Industrial Correspondent, Robert Sheehan, Bridge Correspondent, Alastair Campbell, George Boulos, John Rae, Chris McGrath and Richard Evans, Janet Bush, Economics Editor, Dominic Walsh, Ruth Gledhill, John O'leary, Education Editor, A. W. L. Frentzel-Fraser, Raymond Keene Chess Correspondent, John Street, Tony Mooney, Ruth Gledhill Religion Correspondent, David Jacques, Chairman, Peter Waymark, Sarah Cunningham, Retail Correspondent, Robin Young, Rodney Milnes, Michael Clark, Anatole Kaletsky, Frances Bissell, Charles Bremner, Karen Vincett, Christopher Walker and our Foreign Staff, David Charter, Derwent May, Susan Emmett, John Eliot Gardiner, Geoff Harwood, Jasper Gerard, David M. W. Brooks, Managing Director, Nicholas Watt Political Correspondent, Nigel Williamson, Justin Seabrook, L. Housman, Sydney Friskin, Lin Jenkins, Gabriella Gamini, John Hopkins Golf Correspondent, Raymond Keene, Christine Buckley, Frances Gibb and Philip Webster, Vivian Anthony, Andrew Drummond, Stephen Jones, Richard Evans, Nigel Hawkes, Richard Owen, Sarah Cunningham, Oliver August, Philip Webster, Political Editor, Oliver Holt, Football Correspondent, W. Stephen Gilbert, Damian Whitworth and Polly Newton, Michael Horns, Agriculture Correspondent, Sue Spenceley Burch, Nicholas Wood, John Sykes, Julian Muscat, Jill Sherman and Philip Webster, Christopher Thomas, John Goodbody, Nick Szczepanik and Srikumar Sen, Boxing Correspondent, Kate Weatherell, Nick Nuttall, Technology Correspondent, Jason Nisse, Chris Parker, Michael Horns, Countryside Correspondent, J. Wills, Mel Webb, Gerald Larner, Roderick Strange, Matthew Parris, Russell Jenkins, Caitlin Moran, Walter Gammie, Peter Riddell, Ben MacIntyre, Richard Beeston, Brian Glanville, Philip Webster, Jon Ashworth, Michael Clark and Paul Durman, David Sinclair, Fraser Nelson, Tim Jones, Polly Newton and Nicholas Watt, Martin Waller, Michael Horsnell, Chris Ayres, Clive Coen, John Lloyd is associate editor, Benedict Nightingale, Hugh Thompson, Julian Muscat Tennis Correspondent, Richard Morrison, Robin Lodge, David Maddock, Michael Evans, Anthony Seldon's, Matthew Bond, Robbie Williams, Alexandra Frean, Local Government Correspondent, David Hands, Rugby Correspondent, Christopher Irvine, Christine Buckley, Industrial Correspondent, Valerie Elliott, Whitehall Correspondent,
... successful even French champagne houses such as Mo?tet Chandon are making the prizewinning sparkling wine, says ...
1997 - Gale Group | TDA
... SHV and CTX-M-type beta-lactamase genes, tet(A), (B), (C) and (D) tetracycline resistance genes, chloramphenicol resistance genes and class 1 integrons. Plasmid characterization was carried out by PCR and Southern hybridization analysis. PCR and PFGE were used to characterize nine other S. enterica Agona strains collected from hospitals in Rio de Janeiro.The study strain was found to harbour a 105 kb plasmid, which contained catA1, bla(TEM-1), a class 1 integron with two novel genes labelled bla(OXA-53) and aac(6')-I30, respectively, and an additional unidentified aminoglycoside resistance gene. A second 53 kb plasmid from the same strain contained tet(D) and bla(SHV-5). OXA-53 was ...
Tópico(s): Bacterial biofilms and quorum sensing
2004 - Oxford University Press | Journal of Antimicrobial Chemotherapy
Richard Mabey, Jonathan Northcroft, Tom Kirkman, Waldemar Januszczak, John Dugdale, Hala Jaber, William Kay, Archie Berons, Barbara Hall, Nik Fortune, Nigel Botherway, Paul Lamarra, Geoffrey Howells, Michelene Wandor, Jim Munro, Peter Whittle, Helen Davies, Sally Brock, D M, Rob Hughes, John Peter, Professor Gideon Garter, Amanda Ursell, Jim Brotton, Derek Hodgson, Robin Eggar, Les Worrall, Andrew Longmore, Tim Nagle, Simon Henderson, Gareth Walsh, Frank Whitford, Ivo Tennant, Nicolette Jones, Sybil Kapoor, David Gower, Sam Gilpin, Barbara Deacon, Andrew Taylor, William Lewis, David Smith, Mark Butcher, Irving Kristol father of the US neocons, Peter Sharkey, Nick Pitt, Neil Wormald, Sir Michael Salt, Andrew Sullivan, Martin Brundle, Clive Davis, Antje Winter, Duncan Sprott, Andrew Porter, Tony Allen-Mills, Simon Wilde, Martin James, Robert Sandall, Anthony Sattin, Pat Roberts, Ian Hawkey European Football Correspondent, Irwin Stelzer, William Simon, Matt Rudd, Peter Wilson, Rosie Millard, C H, Ingemar Stenmark, Eric Hansen, Dan Dennis, David Dougill, Emma John, Stuart Barnes, Eric Knowles, Peter Jones, David Hewson, Annabelle Bond, George Foreman, Paul Forsyth, Hugh Mcllvanney, Hugh Canning, Geraldine Hackett Education Correspondent, Lisa Fugard, Jeremy Clarkson, Victoria Segal, Edward Porter, Peter Conradi, Lucy Rouse, Nicola Smith, O Bertram, Colm McKernan, Jack Snow, Bob Walker, Sarah Dempster, Martin Phillips, Dave Pollard, Christopher Price, Anita Chaudhuri, Jonathan Hack, Greg Struthers, Louise Voss, Amanda Blinkhom, Lydia Slater, Jeff Potter, Andrew Porter Deputy Political Editor, Alexa Vega, Robin Scott-Elliot, Stuart Wavell, Sarah-Kate Templeton, Mike Boyce, Michka Assayas, Roger Eglin, Paul Donovan, Ashley Mote Mep, Peter Hounam, Pat Cash, Paul Kimmage, Hugh McIlvanney, Chris Woodhead, Steve Boyd, Jasper Gerard, Paul Driver, Garth Pearce, G Kiernan, John Follain, Ian Hawkey, Stuart Andrews, Shelley Von Strunckel, Christopher Morgan, David Leppard, Tarquin Hall, Paul Durman, Mark Edwards, Leon Paczynski, James Briggs, Rachel Bridge, L K, Terry Bayford, Robert Taylor, Lois Rogers, Professor Kefah Mokbel, Raymond Keene, Gareth Huw Davies, Kate Saunders, Rod Liddle, Lawrence Booth, Peter Davison, Robbie Hudson, Zoe Brennan, Peter Hall, K Jacks, Cosmo Landesman, Diana Jolland, Richard Strudwick, Diana Wright, S B, Emma Smith, Stephen Jones, Dominic O'Connell, Andrew Holgate, Barry Flatman, "Big Charlie" Mosley Editor-in-Chief, Debbie Bartlett, Adrienne Connors, Natalie Graham, John Paul Flintoff, Tim Moorey, Caroline Donald, Keith Brook, Hugh McManners, Jessica Brinton, David Walsh, David Lodge, Helen Brown, Ruth Dudley Edwards, Trevor Lewis, Jeffrey Young, Robert Ballantyne, Colin McDowell, Stephen Armstrong, John Elliott, Colin McDowell's, Mark Anstead, Bethan Cole, R W Johnson, N R, Richard Woods, Roland White, N F, Michelle Paver, Doctor Mark Stucklin, Mark Lancaster founder of SDL International, Shane Watson, Abul Taher, Amrit Dhillon, Barry Nowcombe, Richard Brooks Arts Editor, Joby Williams, Dr John Pitts, Richard Rae, Mark Franchetti, Judith O'Reilly, Ray Hutton, Jon Ungoed-Thomas, John Crossland, Michael Sheridan, Dan Box, Clare Francis, Michael Smith, Brad Pitt, Dr Henry Tegner, John Harlow, Bethan Ryder, Chris Haslam, Mark Kleinman, John Waples, Hunter Davies, A A Gill, Matthew Campbell, Brian Glanville, David Hutcheon, Simon Jenkins, Nick Fielding, Deirdre Fernand, Stephen Pettitt, Jessica Bown, Jonathan Leake Science Editor, Jeremy Langmead, Justin Sparks, Sally Kinnes, Peter James, Naomi Caine, Daniel Emery, Herbert Ypma, David Wickers, Professor Michel Coleman, Peter Almond, Brian Doogan, John Aizlewood, Minette Marrin, Ben Dowell, Clifford Bishop, Mark Hodson, Graham Norwood, David Bellamy, Joe Lovejoy, David Budworth, William Lewis Business editor, Mark Ballard, Hugh Pearman, Dan Cairns, Simon Sebag Montefiore, Stewart Mitchell, Matt Roberts, David Smith Economics Editor, Rodney Smith, Cary Cooper, Rachel De Thame, Tom Deveson, Will Thynee, Sarah Baxter, Margaret Hickman, Fleur Britten, Matthew Goodman, India Knight, Terri Apter, Simon Howard, Jason Dawe, Karen Robinson, Helen Stewart,
... Maxi Priest 2 the Max Relentless Cdrel3 Four Tet Everything Ecstatic Domino Wigcd154 Busdriver Fear of a ...
2005 - Gale Group | Sunday Times HA GDA
Sylvain Rode, Albert Santasusagna Riu, Joan Tort i Donada, María Teresa Vadrí i Fortuny,
... Horts de Sant Jaume, en Perpinyà, vinculados al río Tet. A partir del análisis de los instrumentos de ...
Tópico(s): Historical and socio-economic studies of Spain and related regions
2020 - Universitat Autònoma de Barcelona. Departament de Geografia | Documents d Anàlisi Geogràfica
Produção Nacional
Revisado por pares
Érica L Fonseca, Oksana Mykytczuk, Marise Dutra Asensi, E.M.F. Reis, Lúcia R. Ferraz, Fabiana Lopes de Paula, L.‐K. Ng, D.P. Rodrigues,
... ant(3 " )Ib , sulI and/or sulII , and tet (D) genes as well as an integron-associated aac(6 ′ )-Iq cassette. Eight strains possessed at least four different beta-lactamases with pI profiles that confirmed the presence of both ESBLs and non-ESBLs. Our PFGE profiles indicated that 33 serovar Infantis strains isolated from Rio de Janeiro hospitals came from the same genetic ...
Tópico(s): Vibrio bacteria research studies
2006 - American Society for Microbiology | Journal of Clinical Microbiology
Benjamin List, A. Doehring, Maria T. Hechavarria Fonseca, Andreas Job, Ramón Rios,
We describe a highly efficient new methodology for the synthesis of (E)-α,β-unsaturated esters from aldehydes. In our DMAP-catalyzed reaction, both aromatic as well as aliphatic aldehydes furnish the desired products highly regio- and stereoselectively if treated with commercially available or synthetically easily accessible malonic acid half ester. A large scale application in the synthesis of p-methoxycinnamates, which are of use as sunscreen ingredients, is described.
Tópico(s): Phosphorus compounds and reactions
2005 - Elsevier BV | Tetrahedron
Xavier Companyó, Pierre‐Yves Géant, Andrea Mazzanti, Albert Moyano, Ramón Rios,
An organocatalytic enantioselective synthesis of α-methylene-γ-lactams has been developed. The reaction between protected 2-aminomalonates and Morita–Baylis–Hillman carbonates is catalyzed by chiral Lewis bases to afford the corresponding lactams in excellent yields and moderate to good enantioselectivities, after work-up.
Tópico(s): Synthesis and Biological Activity
2013 - Elsevier BV | Tetrahedron
Alex Zea, Andrea‐Nekane R. Alba, Natalia Bravo, Albert Moyano, Ramón Rios,
Asymmetric organocatalytic additions of anthrones to activated alkenes are discussed. The reaction between anthrone or dithranol and α,β-unsaturated aldehydes is catalyzed by diphenylprolinol trimethylsilyl ether in toluene at −40 °C, giving the Michael adducts with good yields and enantioselectivities. Bifunctional amino-thioureas efficiently catalyze the additions of anthrones to both nitroalkenes and maleimides, and high enantioselectivities can be achieved in both instances at room temperature. ...
Tópico(s): Oxidative Organic Chemistry Reactions
2011 - Elsevier BV | Tetrahedron
Sylva Číhalová, Guillem Valero, Jiří Schimer, Marek Humpl, Martin Dračínský, Albert Moyano, Ramón Rios, Ján Veselý,
The synthesis of piperidines and piperidines derivatives in enantiopure fashion has been a challenging goal for organic chemists. In this report we developed a nice cascade reaction for piperidine derivatives based in an amidomalonate Michael addition to enals followed by an intramolecular hemiaminal formation with good yields and enantioselectivities. Moreover we studied the 'in situ' intramolecular cyclization of this hemiaminals with alcohols forming fused piperidine–oxazolidines.
Tópico(s): Asymmetric Hydrogenation and Catalysis
2011 - Elsevier BV | Tetrahedron
Yitzhak Tor, Susan Del Valle, David Jaramillo, Seergazhi G. Srivatsan, Andro C. Ríos, Haim Weizman,
A convergent approach for a family of fluorescent nucleosides is described. It relies on thieno[3,2-d]pyrimidine-2,4(1H,3H)-dione that serves as a core heterocycle. This condensed pyrimidine is converted into an emissive pyrimidine nucleoside analogue by N-glycosylation and into an emissive purine nucleoside analogue by C-glycosidation at the thiophene's beta position. The design principles of this archetypical system are outlined together with the syntheses and photophysical properties of the resulting ...
Tópico(s): HIV/AIDS drug development and treatment
2007 - Elsevier BV | Tetrahedron
Oscar R. Suárez‐Castillo, M. Sanchez-Zavala, M. Melendez‐Rodriguez, L.E. Castelan-Duarte, Martha S. Morales‐Ríos, Pedro Joseph‐Nathan,
This work describes a general protocol for the oxidation of indole and oxindole derivatives with dimethyldioxirane to give 3-hydroxyoxindoles present in many natural products. This strategy allowed us to synthesize the natural product 1, to carry out the first total synthesis of 4, a formal total synthesis of donaxaridine (5) and to achieve the synthesis of pyrroloindoline 8, a debromo analogue of the natural product flustraminol B (7).
Tópico(s): Bioactive Compounds and Antitumor Agents
2006 - Elsevier BV | Tetrahedron
Luís R. Domingo, Mar Ríos‐Gutiérrez, Patricia Pérez,
The molecular mechanism of the ionic [2+2] cycloaddition (I-22CA) reactions of a keteniminium cation (KC) with acetylene and propyne has been investigated using DFT methods at the MPWB1K/6-311G(d,p) level. These I-22CA reactions take place via a two-step mechanism. The first step is the nucleophilic attack of these alkynes on the central carbon of KC, yielding cyclopropene intermediates, while the second step corresponds to the conversion of these intermediates into more stable cyclobuteniminium cations ( ...
Tópico(s): Fluorine in Organic Chemistry
2015 - Elsevier BV | Tetrahedron
Oscar R. Suárez‐Castillo, Yaneth M. A. Contreras-Martínez, L. Beiza-Granados, M. Melendez‐Rodriguez, José Roberto Villagómez‐Ibarra, J. Martín Torres‐Valencia, Martha S. Morales‐Ríos, Pedro Joseph‐Nathan,
The synthesis of N-carbomethoxy-2-alkoxyindolenines and the transformation to their tautomeric indoles is reported. Variable-temperature 1H NMR studies of these 2-alkoxyindolenines evidenced dynamic processes involving two low-energy E and Z equilibrating conformers around the N–C(O) carbamate bond, for which the barriers (ΔG≠) between the two conformations are in the order of 12.5–13.9 kcal/mol, as deduced from computational NMR line shape simulations. The rotational barrier decreases as the bulkiness ...
Tópico(s): Crystal structures of chemical compounds
2005 - Elsevier BV | Tetrahedron
Ciril Jimeno, Ramón Rios, Patrick J. Carroll, Patrick J. Walsh,
We have observed that dialkylzinc reagents add to atropisomeric 2-formyl arylamides many times faster than they react with other substituted benzaldehyde derivatives. Additionally, with diethylzinc the products were formed with very high diastereoselectivity, affording the syn product (d.r. greater than 95:5), except in one case where epimerization of the product is rapid. In contrast, Grignard and trialkylaluminum reagents afforded the anti diastereomers, with diminished stereoselectivity and formation ...
Tópico(s): Molecular spectroscopy and chirality
2004 - Elsevier BV | Tetrahedron
Daniel Méndez‐Sánchez, Nicolás Ríos‐Lombardía, Vicente Gotor, Vicente Gotor‐Fernández,
A chemoenzymatic and selective method for the epoxidation of a series of cyclic and linear alkenes is described. Epoxides have been obtained in moderate to excellent conversions under mild reaction conditions through a two-step sequence, carried out in one-pot. This chemoenzymatic approach is based on a Rhizomucor miehei lipase-catalyzed perhydrolysis reaction to form the corresponding peracid, and subsequent epoxidation of the corresponding alkenes. Reaction parameters with influence in the biotransformation ...
Tópico(s): Oxidative Organic Chemistry Reactions
2014 - Elsevier BV | Tetrahedron
Enrique A. Castro, Paola R. Campodónico, Renato Contreras, Patricio Fuentealba, José G. Santos, J. Ramón Leis, Luis García‐Río, J.A. Sáez, Luís R. Domingo,
The reactions of quinuclidines with phenyl, 4-methylphenyl, and 4-chlorophenyl 2,4-dinitrophenyl carbonates are kinetically evaluated in aqueous solution. The Brønsted-type plots (log kN vs pKa of quinuclidinium ions) are linear. The magnitude of the slopes and validated theoretical scales of electrophilicity and nucleophilicity confirm the concerted nature of these reactions.
Tópico(s): Chemical Reactions and Mechanisms
2006 - Elsevier BV | Tetrahedron
Daphne E. González‐Juárez, J. Benjamín García‐Vázquez, Violeta Zúñiga-García, Joel J. Trujillo‐Serrato, Oscar R. Suárez‐Castillo, Pedro Joseph‐Nathan, Martha S. Morales‐Ríos,
Abstract The study of Raney-Ni catalyzed chemo- and regioselective hydrogenolysis of diastereomeric nitrile-substituted spirocyclopropyloxindoles is presented. The chemoselectivity outcome of the reaction is remarkably influenced by the relative stereochemistry of the nitrile-substituted spirocyclopropyloxindoles. Chemo- and high regioselective cyclopropane ring-opening occurs from the syn diastereomers to give the corresponding 3-propylacetamide derivatives. X-ray crystallographic studies together ...
Tópico(s): Synthetic Organic Chemistry Methods
2012 - Elsevier BV | Tetrahedron
Produção Nacional
Revisado por pares
Eduardo Q. Luz, Diego Seckler, Janylson Souza Araújo, Leonardo Angst, David B. Lima, Elise Ane Maluf Rios, Ronny R. Ribeiro, Daniel S. Rampon,
A mild and efficient iron (III)-catalyzed C3 chalcogenylation of indoles has been developed and the role of the iodide ions in this transformation was investigated. EPR experiments revealed the reduction of Fe(III) to Fe(II) under the reaction conditions, supporting the formation of molecular iodine in the system, which in effect catalyze the reaction. The scope of the chalcogenylation was broad and the synthesis of more functionalized 3-selenylindoles was explored.
Tópico(s): Catalytic C–H Functionalization Methods
2019 - Elsevier BV | Tetrahedron
Gabriela Mancilla-Montelongo, Marienca Femenia‐Rios, Antonio J. Macías‐Sánchez, Isidro G. Collado,
Tópico(s): Oxidative Organic Chemistry Reactions
2008 - Elsevier BV | Tetrahedron
Luís R. Domingo, Mar Ríos‐Gutiérrez, Patricia Pérez,
The [3+2] cycloaddition (32CA) reactions of the nitrile ylide (NY) with ethylene and with dicyanoethylene (DCE) have been studied using the Molecular Electron Density Theory through DFT calculations at the MPWB1K/6-31G(d) level. The analysis of the electronic structure of NY indicates that it presents a carbenoid structure with an sp2 lone pair at the carbon atom. While the 32CA reaction with ethylene presents a low activation energy, 6.1 kcal mol−1, the transition state structure associated with the ...
Tópico(s): Cyclopropane Reaction Mechanisms
2016 - Elsevier BV | Tetrahedron
Produção Nacional
Revisado por pares
Ana Filipa Moreira Martins, Thaís L. Pinheiro, A. Imperatori, Sérgio Miranda Freire, L. Sá-Freire, Beatriz Meurer Moreira, Raquel Regina Bonelli,
... samples, from all farms. Tetracycline resistance genetic determinants tet(A), tet(C), tet(D), tet(M) and tet(O) were detected in sediment and fecal samples, and tet(A), tet(D) and tet(B) were detected in P. shigelloides isolates. Chloramphenicol ...
Tópico(s): Myxozoan Parasites in Aquatic Species
2018 - Elsevier BV | Aquaculture
José F. Cobo‐Díaz, Paloma González del Río, Avelino Álvarez‐Ordóñez,
... g., dairy products) isolates. The higher incidence of tet(O) , associated with tetracycline resistance, and the gyrA ( ... human clinical settings. Similarly, a high incidence of tet(O) genes of C. coli genomes from pig, ... co-occurrence of the bla OXA– 61 and tet(O)-tet(O/W/O) genes and the gyrA (T86I) ...
Tópico(s): Veterinary medicine and infectious diseases
2021 - Frontiers Media | Frontiers in Microbiology
Luís R. Domingo, Mar Ríos‐Gutiérrez, Patricia Pérez,
The key role of the Global Electron Density Transfer (GEDT) in polar cycloaddition reactions is analysed within the Molecular Electron Density Theory (MEDT) using Density Functional Theory (DFT) calculations at the MPWB1K/6-311G(d) computational level. A comparative MEDT study of the non-polar Diels-Alder reaction between cyclopentadiene (Cp) and ethylene and the polar Diels-Alder reaction between Cp and tetracyanoethylene makes it possible to establish that the GEDT taking place in the direction of ...
Tópico(s): Advanced Chemical Physics Studies
2017 - Elsevier BV | Tetrahedron
Ulises Orlando, Ana F. Castillo, Mayra Agustina Ríos Medrano, Ángela R. Solano, Paula Maloberti, Ernesto J. Podestá,
... mechanisms. To this end, we used MCF-7 Tet-Off/ACSL4 and MDA-MB-231 mock cells, which overexpress ACSL4, and control line MCF-7 Tet-Off empty vector, MDA-MB-231 shRNA ACSL4 ... upon chemotherapeutic treatment were obtained in MCF-7 Tet-Off/ACSL4 and MDA-MB-231 mock cells, ... MB-231 wild type cell proliferation. MCF-7 Tet-Off/ACSL4 cells showed greater doxorubicin, Hoechst 33342 ... genes whose expression was increased in MCF-7 Tet-Off/ACSL4 cells but inhibited in MDA-MB- ...
Tópico(s): Cancer, Lipids, and Metabolism
2018 - Elsevier BV | Biochemical Pharmacology
Krystel Louis, Nathalie C. Guérineau, Olivia Fromigué, Virginie Defamie, Alejandra Collazos, Patrick Anglard, Margaret A. Shipp, Patrick Auberger, Dominique Joubert, Bernard Mari,
... phorbol 12-myristate 13-acetate; ST3, stromelysin-3; Tet, tetracycline; TIMP, tissue inhibitor of matrix metalloproteinases; C/ ... by KpnI/NotI, and finally subcloned into the Tet-inducible vector pCDNA4/TO (Invitrogen). Plasmid containing human ... system (Invitrogen Corp.) was used to obtain a Tet-induced expression system in RD cells. We first ... a stable cell line that constitutively expressed the Tet repressor by RD cells electroporation (400 V, 125 ... Twenty independent subclones were expanded and tested for Tet-inducible gene expression by transient transfection with a ...
Tópico(s): Marine Biology and Environmental Chemistry
2004 - Elsevier BV | Journal of Biological Chemistry
Produção Nacional
Revisado por pares
Tiela Trapp Grassotti, Dejoara de Angelis Zvoboda, Letícia da Fontoura Xavier Costa, A. J. G. Araújo, Rebeca Inhoque Pereira, Renata Oliveira Soares, Paulo Guilherme Carniel Wagner, Jeverson Frazzon, Ana Paula Guedes Frazzon,
... for susceptibility to 12 antibiotics; and screened for tet(S), tet(M), tet(L), msrC and ermB genes by PCR. Two- ... Elevated rates of antibiotic-resistance genes msrC and tet(L) were isolates from ZOO. In conclusion, differences ...
Tópico(s): Biosensors and Analytical Detection
2018 - Frontiers Media | Frontiers in Microbiology