Jonathan Northcroft, Frank Davidson, Waldemar Januszczak, John Dugdale, Sue Green, Matthew Wall, Barbara Hall, Hayley Travers, Nigel Botherway, Jeff Dawson, Tony Barrell, Charlotte Packer, David Brown, Helen Davies, Sally Brock, Nicholas Rufford, Alan Hart, Jason Dawe, John Peter, V S, Colin Brennan, Mark Hodgkinson, Patsy Hammond, Professor Gideon Garter, Jonathan Miller, Andrew Longmore, Andrew Denovan, J D, Max Glaskin, Tim Nagle, Frank Whitford, Bob Geldof, Ivo Tennant, David Smith economics editor, Nicolette Jones, Ferdinand Mount, Dennis Pallis, Kathryn Cooper, Sam Gilpin, Susan Bell, William Lewis, Lucy Hughes-Hallett, David Smith, Michael Boon, Peter Sharkey, Charlie McKechnie, David Cracknell Political Editor, Nick Pitt, Steven Poole, Alister McGuire, Neil Wormald, Andrew Sullivan, Richard Simpson, David Cowdry, Dick Preston, Hilary Hemingway, Karen Robinson, June Miller, Matt Holland, Andrew Porter, Jan Battles, Mark Langford, Martin James, Simon Wilde, Panjabi Hit Squad, Tristram Hunt, Steve Hiett, Tom Walker, Anthony Sattin, Robert Winnett, Sir Steve Redgrave, Irwin Stelzer, Tom English, Robin Scott-Elliott, Rosie Millard, Lawrence Dallaglio, Alice Peters, Rachel Dobson, David Dougill, Emma John, Janet Wilson, Philip Kingsley, Thrasy Petropoulos, Vic Chesnutt, Maurizio Pollini, Anne-Marie Conway, Ian Hoyle, Jonathon Carr-Brown, D Taylor, Alasdair Reid, Hugh Canning, Jeremy Clarkson, David Cairns, Victoria Segal, Howard Goddard, Andrew Morton, Helen Kenny, Patricia Nicol, Sarah Dempster, Kevin Jackson, John O'Donnell, Nick Robinson, Peter Millar, Graham Clutton, Alison Coleman, Rev David Banting National Chairman, David Eimer, Max Clifford, Lydia Slater, Alec Nacamuli, Rupert Wright, S W, Shelley von Strunckel, Jeremy Guscott, Paula Robinson, Basil Sufain, Paul Bailey, Andrew Thomas, Roger Sanchez, Dan Channer, Stuart Wavell, Tom Conran, Dominique Coughlin, Liam Foley, Pat Cash, Frances Spalding, Name withheld, Vincent Crump, Zoe Thomas, Paul Wray, Chris Woodhead, Lucinda Kemeny, Jasper Gerard, Paul Driver, C Rankin, Tricia Jarvis, John Humphrys, Nicholas Hellen, Richard Brooks, Ian Hawkey, Ben Wootliff, Christopher Morgan, David Leppard, Alex Clark, Paul Durman, Peter De Savary, Mark Ludlow, Alicia Wyllie, Dave Hannigan, Andy Webb, Kevin Haworth, Mark Edwards, Rachel Bridge, Jane Nottage, Susan Clark, Eben Black Chief Political Correspondent, Jonathan Hoffman, Bella Bathurst, Chrissy lley, Danny O'Brien, Phil Baker, Bill Edmead, Christina Lamb, Robert Rutledge area director, Lois Rogers, Sean Newsom, Raymond Keene, Tom Landell Mills, Gareth Huw Davies, Jane Packer, Douglas Alexander, Mark Stickings, David Cracknell, Bob Davis business development director, Katrina Manson, Julian Parry, Irene Zoech, Rod Liddle, Cosmo Landesman, Jennifer Capriati, R Welland, Stephen Jones, Robbie Burns, Barry Flatman, Richard Evans, Louise Armitstead, Michael Wright, Natalie Graham, Peter Boyle, Duncan Fitter Strategy manager, Colin Parker, Caroline Donald, Beatrice Newbery, Nick Rennison, S D, Love Tony, M J, Fiona Terry, David Walsh, Trevor Lewis, Colin McDowell, Bryan Appleyard, Simon Edwards general manager, Stephen Armstrong, John Elliott, Mark Anstead, Bethan Cole, Michael Sheridan Far East Correspondent, R W Johnson, Roland White, John, Shane Watson, D J Swami, Deborah Hutton, Maurice Chittenden, Alex Fortune, Richard Brooks Arts Editor, Matthew Taylor MP, Richard Rae, Mark Franchetti, Jonathan Breckland, Ray Hutton, Lauren Quaintance, Naomi Wolf, Michael Sheridan, Lynda Hobson, Mike Smith, Niall Ferguson, Clare Francis, James Cracknell, Godfrey Smith, Ron Hines, Barry Collins, Dipesh Gadher, James Foxall, A A Gill, A M C, Brian Glanville, P Rainer, Jeremy Wayne, Robert MacFarlane, Enda Leahy, David Horspool, Philip Webster, Ed Moloney, Simon Long, Nick Fielding, Stephen Pettitt, Chrissy Iley, Will Iredale, Jane Cattani, Justin Sparks, Kenneth Whayman, Tom Walker Diplomatic Correspondent, Naomi Caine, Nigel Powell, David Wickers, Ken Rauer, Sally Kinnes, Roger Dobson, Brian Doogan, Michael Clower, Simon Buckland, Lord Sudeley, Jeremy Lazell, Will Holland, Jane Robson, Graham Norwood, James Knight, Denise Robertson, Joe Lovejoy, Victor Bryant, David Budworth, William Lewis Business editor, Andrew Davidson, Paul Stephen Lubicz, Dan Cairns, Phillip Knightley, Alistair Cooke General Secretary, David Smith Economics Editor, Phil Smith business development director, Riot mars Harrison, John Thorne, Anthony Howard, Sarah Baxter, Simon Wardell, Chris Feetenby, Kate Spicer, Matthew Goodman, India Knight, Simon Howard, Craig Rowland managing director, Dominic Rushe, Richard Lewis, Sian Griffiths, Niamh Cusack's,
... in the fight for survival Lexus Relative Values Taz and Jarnail Singh We're worlds apart. I' ...
2003 - Gale Group | Sunday Times HA GDA
Anurag Purushothaman, Mohammad Mohajeri, Tanmay P. Lele,
... cytoplasm, while inactivation of the hippo dephosphorylates YAP/TAZ and causes their nuclear translocation where they induce gene expression (56Mohri Z. Del Rio Hernandez A. Krams R. The emerging role of YAP/TAZ in mechanotransduction.J. Thorac. Dis. 2017; 9: E507- ...
Tópico(s): Cell Adhesion Molecules Research
2023 - Elsevier BV | Journal of Biological Chemistry
Diana G. Ríos-López, Ángeles C. Tecalco-Cruz, David Martínez-Pastor, Marcela Sosa‐Garrocho, Gustavo Tapia-Urzúa, Yuli Aranda-López, Bibiana Ortega-Domínguez, Félix Recillas‐Targa, Genaro Vázquez‐Victorio, Marina Macías‐Silva,
The TGF-β and Hippo pathways are critical for liver size control, regeneration, and cancer progression. The transcriptional cofactor TAZ, also named WWTR1, is a downstream effector of Hippo pathway and plays a key role in the maintenance of liver physiological functions. However, the up-regulation of TAZ expression has been associated with liver cancer progression. Recent evidence shows crosstalk of TGF-β and Hippo pathways, since TGF-β modulates TAZ expression through different mechanisms in a ...
Tópico(s): Hippo pathway signaling and YAP/
2023 - Elsevier BV | Heliyon
Zahra Mohri, Armando E. del Río Hernández, Rob Krams,
Cells sense their physical surroundings through mechanotransduction—that is by translating mechanical forces and deformations into biochemical signals that can ultimately influence gene expression, cell shape and cell fate. Recently, YAP/TAZ—the main transcriptional effectors of the Hippo signalling pathway, a major growth regulatory pathway within metazoa—have been identified as key mechanotransducers acting by nuclear relays of mechanical stimuli (1).
Tópico(s): Marine Invertebrate Physiology and Ecology
2017 - AME Publishing Company | Journal of Thoracic Disease
Dietmar Fischer, Heike Diekmann,
In recent years, GSK3 has emerged as a key regulatory kinase in the nervous system, which is involved in diverse processes ranging from neural development to mood stabilization to neurodegeneration. In addition, it has been described as a regulator of several aspects of neural morphology such as polarization, axon growth and branching (Seira and Del Rio, 2014). GSK3 exists as two isoforms (GSK3α and GSK3α), which are both generally expressed throughout the cell body, dendrites and axons of post-mitotic ...
Tópico(s): Hippo pathway signaling and YAP/
2015 - Medknow | Neural Regeneration Research
Gustavo Garcia, Sayan Paul, Sara Beshara, V. Krishnan Ramanujan, Arunachalam Ramaiah, Karin Nielsen‐Saines, Melody M. H. Li, Samuel W. French, Kouki Morizono, Ashok Kumar, Vaithilingaraja Arumugaswami,
... transcriptional co-activator with a PDZ-binding domain (TAZ) silencing results in reduced ZIKV replication, indicating a ... model, ZIKV infection was found to reduce YAP/TAZ protein levels while increasing phosphorylated YAP Ser127 in ... kinase signaling pathway's role in regulating YAP/TAZ in ZIKV-infected cells. These data demonstrate that ... transcriptional co-activator with a PDZ-binding domain (TAZ) silencing results in reduced ZIKV replication, indicating a ... model, ZIKV infection was found to reduce YAP/TAZ protein levels while increasing phosphorylated YAP Ser127 in ...
Tópico(s): interferon and immune responses
2020 - Elsevier BV | American Journal Of Pathology
Produção Nacional
Revisado por pares
Sandro Monticelli Petró, Matias do Nascimento Ritter, M A Pivel, João Carlos Coimbra,
... is widely known as the taphonomically active zone (TAZ). In benthic systems, the TAZ is conventionally considered to be delimited by an ... dissolution is complete. Therefore, we argue that the TAZ concept for pelagic organisms should be extended to ...
Tópico(s): Mercury impact and mitigation studies
2018 - Society for Sedimentary Geology | Palaios
Produção Nacional
Revisado por pares
Diane Nascimento de Oliveira, Thiago Martins Prado,
... das pessoas em mercadorias. Trad. Carlos Alberto Medeiros. Rio de Janeiro: Zahar, 2008. BEY, H. TAZ: zona autônoma temporária. Trad. Renato Rezende e Patrícia ...
Tópico(s): Education and Digital Technologies
2021 - | IPOTESI – REVISTA DE ESTUDOS LITERÁRIOS
Samuel J.I. Blackford, Tracy T. L. Yu, Michael D. A. Norman, Adam M. Syanda, Michail Manolakakis, Dariusz Lachowski, Ziqian Yan, Yunzhe Guo, Elena Garitta, Federica Riccio, Geraldine M. Jowett, Soon Seng Ng, Santiago Vernia, Armando E. del Río Hernández, Eileen Gentleman, S. Tamir Rashid,
... RGD-binding integrins, and increased expression of YAP/TAZ and their transcriptional targets. Alternatively, culture on soft, ... allowed us to identify a role for YAP/TAZ-mediated mechanosensing in hPSC-Hep differentiation.
Tópico(s): Pluripotent Stem Cells Research
2022 - Elsevier BV | Biomaterials
Produção Nacional
Revisado por pares
Matias do Nascimento Ritter, Fernando Erthal, João Carlos Coimbra,
... environments or differences within the taphonomically active zone (TAZ). Dissolution seems to be a leading taphonomic agent ... shells from the two outcrops are within the TAZ and, due to intense dissolution, they will most ...
Tópico(s): Marine animal studies overview
2013 - Elsevier BV | Quaternary International
Alistair Rice, E Cortés, Dariusz Lachowski, Brian C. H. Cheung, Saadia A. Karim, Jennifer P. Morton, Armando E. del Río Hernández,
... expression, nuclear localisation of β-catenin, YAP and TAZ and changes in cell shape towards a mesenchymal ...
Tópico(s): Cellular Mechanics and Interactions
2017 - Springer Nature | Oncogenesis
Andrea Zancla, Pamela Mozetic, Monica Orsini, Giancarlo Forte, Alberto Rainer,
... to understand the function and regulation of YAP/TAZ proteins, which are known to play a pivotal ... Cai Q. Xu Y. Hypoxic conditions differentially regulate TAZ and YAP in cancer cells.Arch. Biochem. Biophys. ...
Tópico(s): Advanced Electron Microscopy Techniques and Applications
2022 - Elsevier BV | Journal of Biological Chemistry
Mitchell Koolpe, Monique Dail, Elena B. Pasquale,
... W. Ellerby L.M. Kain R. Andrusiak R. Rio G.D. Krajewski S. Lombardo C.R. Rao ... W. Ellerby L.M. Kain R. Andrusiak R. Rio G.D. Krajewski S. Lombardo C.R. Rao ... W. Ellerby L.M. Kain R. Andrusiak R. Rio G.D. Krajewski S. Lombardo C.R. Rao ... W. Ellerby L.M. Kain R. Andrusiak R. Rio G.D. Krajewski S. Lombardo C.R. Rao ... W. Ellerby L.M. Kain R. Andrusiak R. Rio G.D. Krajewski S. Lombardo C.R. Rao ... W. Ellerby L.M. Kain R. Andrusiak R. Rio G.D. Krajewski S. Lombardo C.R. Rao ...
Tópico(s): Angiogenesis and VEGF in Cancer
2002 - Elsevier BV | Journal of Biological Chemistry
Fabien Llambi, Filipe C. Lourenço, Devrim Gözüaçık, Catherine Guix, Laurent Pays, Gabriel del Rio, Adi Kimchi, Patrick Mehlen,
... for more papers by this author Gabriel Del Rio Gabriel Del Rio The Buck Institute for Age Research, Novato, CA, ... for more papers by this author Gabriel Del Rio Gabriel Del Rio The Buck Institute for Age Research, Novato, CA, ...
Tópico(s): Neurogenesis and neuroplasticity mechanisms
2005 - Springer Nature | The EMBO Journal
... evolution in drained lake basins on the Pur-Taz Interfluve, North-Western Siberia, Quaternary International 669 (Sep ... lagoons systems of the littoral of the outer Río de la Plata estuary, Science of The Total ...
Tópico(s): Soil erosion and sediment transport
1922 - University of Chicago Press | The Journal of Geology
Sophia S. Bryant, Scott Briggs, Thomas E. Smithgall, George A. Martin, Frank McCormick, Jinhong Chang, Sarah J. Parsons, Richard Jove,
... H. Mayer B.J. Overduin M. Resh M. Rios C. Silverman L. Kuriyan J. Nature. 1992; 358: ... H. Mayer B.J. Overduin M. Resh M. Rios C. Silverman L. Kuriyan J. Nature. 1992; 358: ... H. Mayer B.J. Overduin M. Resh M. Rios C. Silverman L. Kuriyan J. Nature. 1992; 358: ...
Tópico(s): Hippo pathway signaling and YAP/
1995 - Elsevier BV | Journal of Biological Chemistry
Fabien Llambi, Frédéric Causeret, Evelyne Bloch‐Gallego, Patrick Mehlen,
... probably displays no ability to homodimerize (G.del Rio, personal communication). In any case, both Fas and ... of UNC5H-expressing constructs. We thank G.del Rio for helpful discussion and L.Granger for excellent ...
Tópico(s): Hedgehog Signaling Pathway Studies
2001 - Springer Nature | The EMBO Journal
Produção Nacional
Revisado por pares
Maiara Bettinelli, Sérgio R. Dillenburg, Renato Pereira Lopes, Felipe Caron,
... by rapid burial below the Taphonomically Active Zone (TAZ). The presence of marine species together with species ...
Tópico(s): Geological formations and processes
2018 - Elsevier BV | Journal of South American Earth Sciences
Dariusz Lachowski, Ernesto Cortés, Benjamin Robinson, Alistair Rice, Krista Rombouts, Armando E. del Río Hernández,
... E., Robinson, B., Rice, A., Rombouts, K., Del Río Hernández, A. E. FAK controls the mechanical activation ...
Tópico(s): Marine Invertebrate Physiology and Ecology
2017 - Wiley | The FASEB Journal
James R. Lupski, Jeffrey G. Reid, Claudia Gonzaga‐Jauregui, David Rio Deiros, David C.Y. Chen, Lynne Nazareth, Matthew N. Bainbridge, Huyen Dinh, Chyn Jing, David A. Wheeler, Amy L. McGuire, Feng Zhang, Paweł Stankiewicz, John Halperin, Chengyong Yang, Curtis Gehman, Danwei Guo, Rola K. Irikat, Warren Tom, Nick J. Fantin, Donna M. Muzny, Richard A. Gibbs,
Whole-genome sequencing may revolutionize medical diagnostics through rapid identification of alleles that cause disease. However, even in cases with simple patterns of inheritance and unambiguous diagnoses, the relationship between disease phenotypes and their corresponding genetic changes can be complicated. Comprehensive diagnostic assays must therefore identify all possible DNA changes in each haplotype and determine which are responsible for the underlying disorder. The high number of rare, ...
Tópico(s): Hippo pathway signaling and YAP/
2010 - Massachusetts Medical Society | New England Journal of Medicine
Valérie Kedinger, Fabien Alpy, Aurélie Baguet, Myriam Polette, Isabelle Stoll, Marie‐Pierre Chenard, Catherine Tomasetto, Marie‐Christine Rio,
Background Despite numerous in vivo evidences that Tumor Necrosis Factor Receptor-Associated Factor 4 (TRAF4) plays a key biological function, how it works at the cellular and molecular level remains elusive. Methodology/Principal Findings In the present study, we show using immunofluorescence and immuohistochemistry that TRAF4 is a novel player at the tight junctions (TJs). TRAF4 is connected to assembled TJs in confluent epithelial cells, but accumulates in the cytoplasm and/or nucleus when TJs ...
Tópico(s): Hippo pathway signaling and YAP/
2008 - Public Library of Science | PLoS ONE
Victoria E. Abraira, Tony del Rio, Andrew F. Tucker, John Slonimsky, Hannah L. Keirnes, Lisa V. Goodrich,
The sense of balance depends on the intricate architecture of the inner ear, which contains three semicircular canals used to detect motion of the head in space. Changes in the shape of even one canal cause drastic behavioral deficits, highlighting the need to understand the cellular and molecular events that ensure perfect formation of this precise structure. During development, the canals are sculpted from pouches that grow out of a simple ball of epithelium, the otic vesicle. A key event is the ...
Tópico(s): Hippo pathway signaling and YAP/
2008 - The Company of Biologists | Development
Patricia Rojas‐Ríos, Isabel Guerrero, Acaimo González‐Reyes,
Stem cells reside in specialised microenvironments, or niches, which often contain support cells that control stem cell maintenance and proliferation. Hedgehog (Hh) proteins mediate homeostasis in several adult niches, but a detailed understanding of Hh signalling in stem cell regulation is lacking. Studying the Drosophila female germline stem cell (GSC) niche, we show that Hh acts as a critical juxtacrine signal to maintain the normal GSC population of the ovary. Hh production in cap cells, a type ...
Tópico(s): Hippo pathway signaling and YAP/
2012 - Public Library of Science | PLoS Biology
Ruby Yun‐Ju Huang, Parry Guilford, Jean Paul Thiery,
... Talin and p130CAS (also known as BCAR1) (del Rio et al., 2009; Sawada et al., 2006).Apical- ...
Tópico(s): Cancer Cells and Metastasis
2012 - The Company of Biologists | Journal of Cell Science
Raúl Ríos, Juan Ortega, Luís Fernández,
... at the working pressure: (x1,az = 0.404; Taz = 367.65 K). Measurements of (T,pio) are ...
Tópico(s): Chemical Thermodynamics and Molecular Structure
2012 - American Chemical Society | Journal of Chemical & Engineering Data
Taro Yoshikawa, Aki Mizuno, Hirofumi Yasumuro, Wataru Inami, M. Natalia Vergara, Katia Del Rio‐Tsonis, Chikafumi Chiba,
The onset mechanism of proliferation in mitotically quiescent retinal pigment epithelium (RPE) cells is still obscure in humans and newts, although it can be a clinical target for manipulating both retinal diseases and regeneration. To address this issue, we investigated factors or signaling pathways involved in the first cell-cycle entry of RPE cells upon retinal injury using a newt retina-less eye-cup culture system in which the cells around the wound edge of the RPE exclusively enter the cell ...
Tópico(s): Glaucoma and retinal disorders
2011 - Wiley | Pigment Cell & Melanoma Research
Jonathan Rios‐Doria, Rainer Kuefer, Stephen P. Ethier, Mark L. Day,
Abstract Mutations in the NH2-terminal regulatory domain of the β-catenin gene lead to aberrant stabilization and accumulation of the protein and increased TCF/LEF-dependent transcription. Although these mutations are common in some cancers, they are infrequent in prostate and breast cancer. We have found that metastatic prostate cancer specimens, obtained through a rapid autopsy tissue procurement program, expressed a novel Mr 75,000 proteolytic fragment of β-catenin (β-cat75). β-Cat75 was also ...
Tópico(s): Hippo pathway signaling and YAP/
2004 - American Association for Cancer Research | Cancer Research
Corinna Steindler, Zhi Li, Michèle Algarté, Andrés Alcover, Valentina Libri, Josiane Ragimbeau, Sandra Pellegrini,
... C. Ramos-Morales F. Fedriani C. Bornens M. Rios R.M. J. Cell Biol. 1999; 145: 83- ...
Tópico(s): Microtubule and mitosis dynamics
2004 - Elsevier BV | Journal of Biological Chemistry
Akihiko Komuro, Makoto Nagai, Nicholas E. Navin, Marius Sudol,
... K. Corfas G. Paul S. Choi C.J. Rio C. Plowman G.D. Klagsbrun M. J. Biol. ...
Tópico(s): Wnt/β-catenin signaling in development and cancer
2003 - Elsevier BV | Journal of Biological Chemistry
Paolo De Los Rios, Fabio Cecconi, Anna Pretre, Giovanni Dietler, Olivier Michielin, Francesco Piazza, Brice Juanico,
Postsynaptic density-95/disks large/zonula occludens-1 (PDZ) domains are relatively small (80-120 residues) protein binding modules central in the organization of receptor clusters and in the association of cellular proteins. Their main function is to bind C-terminals of selected proteins that are recognized through specific amino acids in their carboxyl end. Binding is associated with a deformation of the PDZ native structure and is responsible for dynamical changes in regions not in direct contact ...
Tópico(s): Protein Structure and Dynamics
2005 - Elsevier BV | Biophysical Journal