Taki, Carlos Alba, Waldemar Januszczak, John Dugdale, Anderson, Mark Stretton, Barbara Hall, Catherine Hayward, Girly hell, Tony Barrell, R Dunne, Steve Jones, Victor Adebowale, Matt Getz, N J, David Brown, James Clark, Rob Hughes, John Peter, Mrs C A Waters, Marlon Martin, Emma Moore, Jonathan Miller, Martin Hodgson, Lesley White, Adam Hathaway, John Jay, J D, Anna Smith, James Peterson, Kathryn Leigh, Emine Saner, Frank Whitford, Ivo Tennant, Les Robinson, Winning Oz shiraz, Matt Wolf, Alistair Scott, Kathryn Cooper, Sally Payne, David Smith, Alan Reeves, John Waples Editor, Kirstie Hamilton City Editor, Humphrey Carpenter, Steve Smith, Melanie Phillips, David Pearson, Neil Wormald, E P, Andrew Sullivan, Robert Childs, Clive Davis, Stephen Grey, Mary Wilson, Dr Roger Henderson, C D, A C, Joseph Dunn, Chris Fautley, Martin James, Simon Wilde, Tom Walker, Susan d'ARCY, Anthony Sattin, V Brown, Robert Winnett, Alison Brace, Irwin Stelzer, Judy Finnigan, Jane Moore, Peter Wilson, David Dougill, Rachel Dobson, Herb Kane, Alexander Santos, John Evans, Philip Kingsley, Isabella Tree, Steve Curry, Sarah Toyne, Tony Harris, Mike Gleeson, Elspeth Campbell, David Hewson, Tania Alexander, Hugh Canning, Alasdair Reid, Hugh Mcllvanney, Paul Ourman, Margarette Driscoll, Jeremy Clarkson, Stewart Lee, Edward Porter, Philip Mansel, Peter Kemp, Louise Taylor, Best Bargain, Cheryl Markosky, Eben Black, Robert Harris, Peter Millar, Liz Jones, Phil Craigie, Richard Brooks Editor, Liz Phillips, Adam Nathan, T Snell, Nick Gardner, Ian Robinson, Lois Rogers Correspondent, Jonathan Margolis, A T Smythe, Alan Langleben, Peter Parker, Mike Laws, Roger Eglin, Stella Bingham, Josephine Smit, Paul Donovan, Sarah Bailey, Alastair Hendy, Winner, Dominique Coughlin, Liz Bailey, Martin Williams, John Woods, Susan Clark Health Journalist, Lucinda Kemeny, Jasper Gerard, Paul Driver, Erika Fabarius, Michael Woodhead, John Humphrys, David Thomas, Maeve Sheehan, Nicholas Hellen, Richard Price, John Follain, Ian Hawkey, Peter Windsor, L C Patridge, Stan Butler, Ralph Gretton, David Leppard, Paul Durman, Felipe Fernandez-Armesto, Shelley Von Strunckel, Matthew Gwyther, Alicia Wyllie, Mark Edwards, Kirstie Hamilton, Joss Bolton, Susan Clark, David Lawrenson, C M, Deborah Collcutt Consumer Affairs Correspondent, David Weston, James Clark Correspondent, Alan Combes, Raymond Keene, Senay Boztas, Cosmo Landesman, Marie Colvin, Colin Smith, Diana Wright, R W, Roy Stead, David Orr, Nicolas Hayek, Chris Partridge, Stephen Jones, S B, Uzi Mahnaimi, Nick Cain, Michael Wright, Caroline Scott, June Field, Natalie Graham, Paul Nuki, Sue Fox, M J, Caroline Donald, N G, Rob Ryan, Claire Oldfield, David Walsh, V W, Trevor Lewis, Susan Redstone, Colin McDowell, Lois Rogers Medical Correspondent, G Kent, Stephen Armstrong, John Elliott, Emily Milich, Ron Clarke, Mark Scarratt, Paul Kavanagh, Charlotte Grace, Mark Prigg, Victoria O'brien, Diana, Garth Alexander, Tom Stoddart, Maurice Chittenden, Alex Fortune, Kevin Pratt, M W, Norman Baker, Richard Rae, Mark Franchetti, David Rees, Jonathan Powell, Jon Ungoed-Thomas, Martin Ivens, Ray Hutton, Jean Mercer, Jenny Uglow, Kevin Halloran, D J Taylor, Amanda Craig, Christine Webb, Godfrey Smith, Donald McRae, Alan Hardy, John Urbanek, Dipesh Gadher, M Newton, Hilary Lowe, Don Black, John Waples, Hunter Davies, Curtis Goodes, A A Gill, Matthew Campbell, Brian Glanville, Lawrence Dailaglio, Max Stafford-Clark, John Carey, Colin Gibson, J Vanvilet, Tom Robbins, David Sumner Smith, Harvey Jones, N W, Nick MacKinnon, Stephen Pettitt, Lewis Stuart, Chrissy Iley, Trushar Barot, Jonathan Leake Science Editor, A Swann, Peter Fieldman, Howard Jacobson, Adam Faith, T L, Sally Kinnes, Virginia Wallis, Donald Marcus, Liam Clarke, David Wickers, Professor Ian Craft, Tom Rhodes, Patrick Jephson, Dr Raj Persaud, John Aizlewood, John May, John Cornwell, Graham Norwood, Joe Lovejoy, Rupert Steiner, John Borthwick, Hugh Pearman, Dan Cairns, Julian Ryall, David Parsley, Collin Clark, Joenna Simon, Niels Hollander, Neil MacLean, John Burns, Mrs Mills, Simon Crerar, Anthony Howard, David Long, India Knight, Steve Grant, Simon Howard, Dan Pearson, Dominic Rushe, Leslie Geddes-Brown, Kate Constable, Boris Schapiro, Bob Latham, Michael Prescott Editor,
... not to annoy TLC's Lisa 'Left Eye' Lopes, says Dan Cairns - she might just burn your ...
2000 - Gale Group | Sunday Times HA GDA
Vanessa M. Lopes, Ana Rita Lopes, Pedro Reis Costa, Rui Rosa,
Here we summarize the current knowledge on the transfer and accumulation of harmful algal bloom (HAB)-related toxins in cephalopods (octopods, cuttlefishes and squids). These mollusks have been reported to accumulate several HAB-toxins, namely domoic acid (DA, and its isomers), saxitoxin (and its derivatives) and palytoxin (and palytoxin-like compounds) and, therefore, act as HAB-toxin vectors in marine food webs. Coastal octopods and cuttlefishes store considerably high levels of DA (amnesic shellfish ...
Tópico(s): Nicotinic Acetylcholine Receptors Study
2013 - Multidisciplinary Digital Publishing Institute | Marine Drugs
Tiago Repolho, Miguel Baptista, Marta S. Pimentel, Gisela Dionísio, Katja Trübenbach, Vanessa M. Lopes, Ana Rita Lopes, Ricardo Calado, Mário Diniz, Rui Rosa,
Tópico(s): Neurobiology and Insect Physiology Research
2013 - Springer Science+Business Media | Journal of Comparative Physiology B
Maria Aurélio, Filipa Faleiro, Vanessa M. Lopes, Vanessa Pires, Ana Rita Lopes, Marta S. Pimentel, Tiago Repolho, Miguel Baptista, Luı́s Narciso, Rui Rosa,
The aim of the present study was to evaluate, for the first time, the effect of environmental warming on the metabolic and behavioral ecology of a temperate seahorse, Hippocampus guttulatus. More specifically, we compared routine metabolic rates, thermal sensitivity, ventilation rates, food intake, and behavioral patterns at average spring temperature (18 °C), average summer temperature (26 °C), temperatures that they endure during summer heat wave events (28 °C), and in a near-future warming scenario (+ ...
Tópico(s): Aquaculture Nutrition and Growth
2013 - Springer Science+Business Media | Marine Biology
Alessandro Russo, Ana Rita Lopes, Michael G. McCusker, Sandra Gimenez Garrigues, Giuseppina Rosaria Rita Ricciardi, Katherine E. Arensmeyer, Katherine A. Scilla, Ranee Mehra, Christian Rolfo,
Tópico(s): Lung Cancer Research Studies
2020 - Springer Science+Business Media | Current Oncology Reports
Ana Rita Lopes, Eduardo Sampaio, Catarina Pereira Santos, Ana Couto, Maria Rita Pegado, Mário Diniz, Philip L. Munday, Jodie L. Rummer, Rui Rosa,
Sharks have maintained a key role in marine food webs for 400 million years and across varying physicochemical contexts, suggesting plasticity to environmental change. In this study, we investigated the biochemical effects of ocean acidification (OA) levels predicted for 2100 (pCO2 ~ 900 μatm) on newly hatched tropical whitespotted bamboo sharks (Chiloscyllium plagiosum). Specifically, we measured lipid, protein, and DNA damage levels, as well as changes in the activity of antioxidant enzymes and non- ...
Tópico(s): Physiological and biochemical adaptations
2018 - Springer Science+Business Media | Cell Stress and Chaperones
P. F. Scholander, Walter Flagg, Vladimir Walters, Laurence Irving,
... org/10.1371/journal.pone.0108539Rui Rosa, Ana Rita Lopes, Marta Pimentel, Filipa Faleiro, Miguel Baptista, Katja Trübenbach, Luis Narciso, Gisela Dionísio, Maria Rita Pegado, Tiago Repolho, Ricardo Calado, Mário Diniz Ocean ...
Tópico(s): Cephalopods and Marine Biology
1953 - University of Chicago Press | Physiological Zoology
Rui Rosa, Ana Rita Lopes, Marta S. Pimentel, Filipa Faleiro, Miguel Baptista, Katja Trübenbach, Luı́s Narciso, Gisela Dionísio, Maria Rita Pegado, Tiago Repolho, Ricardo Calado, Mário Diniz,
Abstract Cleaning symbioses play an important role in the health of certain coastal marine communities. These interspecific associations often occur at specific sites (cleaning stations) where a cleaner organism (commonly a fish or shrimp) removes ectoparasites/damaged tissue from a ‘client’ (a larger cooperating fish). At present, the potential impact of climate change on the fitness of cleaner organisms remains unknown. This study investigated the physiological and biochemical responses of tropical ( ...
Tópico(s): Marine Bivalve and Aquaculture Studies
2014 - Wiley | Global Change Biology
Apostolia Fragkouli, Nicole Verhey van Wijk, Rita Lopes, Nicoletta Kessaris, Vassilis Pachnis,
Coordination of voluntary motor activity depends on the generation of the appropriate neuronal subtypes in the basal ganglia and their integration into functional neuronal circuits. The largest nucleus of the basal ganglia, the striatum, contains two classes of neurons: the principal population of medium-sized dense spiny neurons (MSNs; 97-98% of all striatal neurons in rodents), which project to the globus pallidus and the substantia nigra, and the locally projecting striatal interneurons (SINs; ...
Tópico(s): Zebrafish Biomedical Research Applications
2009 - The Company of Biologists | Development
Tristan R. McKay, Stephen Bell, Tencho Tenev, Viola Stoll, Rita Lopes, Nicholas R. Lemoine, Iain A. McNeish,
Tópico(s): CRISPR and Genetic Engineering
2003 - Springer Nature | Oncogene
Olivier E. Pardo, Adeline Lesay, Alexandre Arcaro, Rita Lopes, Bee Ling Ng, Patricia H. Warne, Iain A. McNeish, Teresa D. Tetley, Nicholas R. Lemoine, Huseyin Mehmet, Michael J. Seckl, Julian Downward,
The mitochondrial release of cytochrome c and Smac/DIABLO has been implicated in the activation of apoptosis in response to cell stress. Smac promotes cytochrome c-induced activation of caspases by sequestering the inhibitor of apoptosis protein (IAP) family of potent caspase suppressors. Differential release from mitochondria of cytochrome c and Smac can occur, but the underlying mechanism and physiological significance of this are unclear. Here we show that the mechanism by which fibroblast growth ...
Tópico(s): RNA modifications and cancer
2003 - Taylor & Francis | Molecular and Cellular Biology
Michela Marani, David C. Hancock, Rita Lopes, Tencho Tenev, Julian Downward, Nicholas R. Lemoine,
Selective and sustained activation of the Raf/MAP kinase pathway in MCF-10A ΔRaf-ER cells, a spontaneously immortalized human mammary epithelial cell line, was previously shown to protect these cells from suspension-induced cell death, a critical feature of the Ras-transformed phenotype. Although autocrine signalling through the EGF receptor is crucial for the protection induced by Raf in these cells, we report here the existence of an additional, more direct survival mechanism, linking Raf activation ...
Tópico(s): Melanoma and MAPK Pathways
2003 - Springer Nature | Oncogene
Nuno Videira, Paula Antunes, Rui Santos, Rita Lopes,
Abstract Several authors have described the usefulness of participatory system dynamics approaches in environmental decision‐making processes, particularly in supporting problem scoping and policy analysis. This paper explores how these approaches may be expanded to provide a coherent, deliberative platform, which structures Integrated Sustainability Assessments (ISA) of policy proposals. The proposed ISA framework forms a five‐stage feedback and learning process including scoping, visioning, model ...
Tópico(s): Environmental and Social Impact Assessments
2010 - Wiley | Systems Research and Behavioral Science
Rita Lopes, Rathi Gangeswaran, Iain A. McNeish, Yaohe Wang, Nicholas R. Lemoine,
Abstract Pancreatic cancer is one of the most aggressive human tumors with a 5‐year survival rate of only 3% and a striking resistance to chemotherapy and radiotherapy. The search for new therapeutic approaches includes strategies exploiting the deregulation of apoptotic pathways commonly found in cancer cells. The IAP proteins are inhibitors of apoptosis that have altered activity in numerous cancer types and are implicated in resistance to chemotherapy, and therefore are potentially interesting ...
Tópico(s): Ubiquitin and proteasome pathways
2007 - Wiley | International Journal of Cancer
André Pontes da Costa, Rita Lopes, João M. S. Cardoso, J.A. Mata, Eduardo Peris, Beatriz Royo,
Novel enantiomerically pure cyclopentadienyl- and indenyl-functionalized N-heterocyclic carbene ligands have been prepared by reaction of a chiral imidazole tosylate derivative with the corresponding cyclopentadienyl and indenyl lithium salts. Coordination of the Cp-functionalized NHC ligand to iridium and rhodium allowed the preparation of enantiomerically pure chelating cyclopentadienyl-functionalized Ir(III) and Rh(III) metal complexes. In contrast, the indenyl-functionalized NHC coordinates ...
Tópico(s): Asymmetric Hydrogenation and Catalysis
2011 - American Chemical Society | Organometallics
Nuno Videira, Rita Lopes, Paula Antunes, Rui Santos, José Casanova,
Improving formulation and implementation of sustainable strategies is increasingly dependent upon more integrated and participatory decision‐making processes. This paper explores the use of qualitative system dynamics tools and a participatory modelling approach to support scoping stages of an integrated sustainability assessment (ISA) process. To facilitate mapping of maritime sustainability issues in Portugal, a series of preparatory interviews allowed eliciting stakeholders’ perceptions and their ...
Tópico(s): Environmental and Social Impact Assessments
2012 - Wiley | Systems Research and Behavioral Science
Rita Lopes, Nicole Verhey van Wijk, Guilherme Neves, Vassilis Pachnis,
The generation and maintenance of a plethora of neuronal subtypes is essential for normal brain function. Nevertheless, little is known about the molecular mechanisms that maintain the defining characteristics of neurons following their initial postmitotic specification. Using conditional gene ablation in mice, we demonstrate here that the homeodomain protein LIM homeobox (Lhx)7 is essential for maintaining the morphological and molecular characteristics of cholinergic interneurons of the striatum. ...
Tópico(s): Congenital heart defects research
2012 - National Academy of Sciences | Proceedings of the National Academy of Sciences
Masanori Akada, Tatjana Crnogorac‐Jurcevic, Samuel Lattimore, Patrick C. Mahon, Rita Lopes, Makoto Sunamura, Seiki Matsuno, Nicholas R. Lemoine,
Although chemotherapy with gemcitabine is a common mode of treatment of pancreatic cancer, 75% of patients do not benefit from this therapy. It is likely that the sensitivity of cancer cells to gemcitabine is determined by a number of different factors.To identify genes that might contribute to resistance to gemcitabine, 15 pancreatic cancer cell lines were subjected to gemcitabine treatment. Simultaneously, gene expression profiling using a cDNA microarray to identify genes responsible for gemcitabine ...
Tópico(s): Cancer Genomics and Diagnostics
2005 - American Association for Cancer Research | Clinical Cancer Research
José M. Arencibia, M. Del Rı́o, Ana Bonnin, Rita Lopes, Nicholas R. Lemoine, M López-Barahona,
Doxazosin is a quinazoline-based compound acting as an alpha-1-adrenergic inhibitor shown to induce apoptosis in prostate cancer cell lines via an alpha-1-adrenergic receptor-independent mechanism. To better understand the mechanism of doxazosin-induced apoptosis in prostate cancer, we performed cDNA microarray to analyze gene expression changes produced by doxazosin in the androgen-dependent human prostate cancer cell line, LNCaP. We found that 70 and 92 genes were deregulated after 8 and 24 h ...
Tópico(s): Estrogen and related hormone effects
2005 - Spandidos Publishing | International Journal of Oncology
João M. S. Cardoso, Rita Lopes, Beatriz Royo,
A new series of tetramethylcyclopentadienyl-functionalised N-heterocyclic carbene complexes of iron bearing different wingtips of general type (Cp*-NHCR)Fe(CO)I (R = nBu, iBu, Et, CH2CH2OMe, CH2Ph) were prepared by direct reaction of Fe3(CO)12 and the corresponding imidazolium proligands. These new iron-NHC complexes have been found to be efficient catalysts for the dehydrogenative silylation of alcohols with silanes. Iron metal complexes bearing iso-butyl and n-butyl wingtips displayed slightly better ...
Tópico(s): Catalytic Cross-Coupling Reactions
2014 - Elsevier BV | Journal of Organometallic Chemistry
Rita Lopes, João M. S. Cardoso, Lorena Postigo, Beatriz Royo,
Tópico(s): Asymmetric Hydrogenation and Catalysis
2013 - Springer Science+Business Media | Catalysis Letters
The complex nature of marine and coastal ecosystems combined with the inaccessibility and invisibility of the majority of their goods and services call for tailored approaches to valuation. Furthermore, a deliberative approach is necessary to support emerging policy initiatives and decision-making processes, and this paper presents a participatory framework for valuing marine and coastal ecosystem services. The framework provides a coherent process for the identification and valuation of these services ...
Tópico(s): Coral and Marine Ecosystems Studies
2013 - Elsevier BV | Ocean & Coastal Management
Lorena Postigo, Rita Lopes, Beatriz Royo,
A series of new tetramethylcyclopentadienyl-functionalised N-heterocyclic carbene ligands with different wingtip substituents have been prepared and characterised. These ligands have been successfully coordinated to nickel affording complexes of the general type (Cp*-NHC(R))NiX (X = Cl, I). These well-defined nickel complexes selectively catalysed the coupling of aromatic thiols with Et3SiH to give the corresponding silylthioethers (RSSiEt3). The nickel complexes bearing ethyl, iso-butyl, and n-butyl ...
Tópico(s): Catalytic C–H Functionalization Methods
2013 - Royal Society of Chemistry | Dalton Transactions
Ana Rita Lopes, Katja Trübenbach, Tatiana Fiche Salles Teixeira, Vanessa M. Lopes, Vanessa Pires, Miguel Baptista, Tiago Repolho, Ricardo Calado, Mário Diniz, Rui Rosa,
Diel vertical migrators, such as myctophid fishes, are known to encounter oxygen minimum zones (OMZ) during daytime in the Eastern Pacific Ocean and, therefore, have to cope with temperature and oxidative stress that arise while ascending to warmer, normoxic surface waters at night-time. The aim of this study was to investigate the antioxidant defense strategies and heat shock response (HSR) in two myctophid species, namely Triphoturus mexicanus and Benthosema panamense, at shallow and warm surface ...
Tópico(s): Marine Bivalve and Aquaculture Studies
2013 - Elsevier BV | Deep Sea Research Part I Oceanographic Research Papers
Abstract A participatory system dynamics modelling approach is advanced to support conceptualization of feedback processes underlying ecosystem services and to foster a shared understanding of leverage intervention points. The process includes systems mapping workshop and follow-up tasks aiming at the collaborative construction of causal loop diagrams. A case study developed in a natural area in Portugal illustrates how a stakeholder group was actively engaged in the development of a conceptual ...
Tópico(s): Land Use and Ecosystem Services
2015 - De Gruyter Open | Environmental and Climate Technologies
Yu Ren, Hitomi Suzuki, Krishna Jagarlamudi, Kayla Golnoski, Megan McGuire, Rita Lopes, Vassilis Pachnis, Aleksandar Rajkovic,
The early stages of ovarian follicle formation—beginning with the breakdown of germ cell cysts and continuing with the formation of primordial follicles and transition to primary and secondary follicles—are critical in determining reproductive life span and fertility. Previously, we discovered that global knockouts of germ cell-specific transcriptional co-regulators Sohlh1, Sohlh2, Lhx8, and Nobox, cause rapid oocyte loss and ovarian failure. Also factors such as Nobox and Sohlh1 are associated ...
Tópico(s): FOXO transcription factor regulation
2015 - BioMed Central | BMC Biology
Produção Nacional
Revisado por pares
Rui Rosa, José Ricardo Paula, Eduardo Sampaio, Marta S. Pimentel, Ana Rita Lopes, Miguel Baptista, Miguel Guerreiro, Catarina Pereira Santos, Derek Felipe Campos, Vera Maria Fonseca de Almeida‐Val, Ricardo Calado, Mário Diniz, Tiago Repolho,
Tópico(s): Coral and Marine Ecosystems Studies
2016 - Springer Science+Business Media | Marine Biology
Ana Rita Lopes, Miguel Baptista, Inês C. Rosa, Gisela Dionísio, José Nuno Gomes‐Pereira, José Ricardo Paula, Cátia Figueiredo, Narcisa M. Bandarra, Ricardo Calado, Rui Rosa,
Marine pleustonic species such as the hydrozoans Velella velella and Physalia physalis, are known to drift in the world's oceans driven by winds, currents and tides. Here we present the first chemotaxonomic characterization, based on the fatty acid (FA) profile, of these two charismatic oceanic species that thrive in the interface layer between air and the water column in adult stages. Moreover, we compared their FA profiles with those from other representative cnidarian orders (Rhizostomeae, Anthomedusae, ...
Tópico(s): Coral and Marine Ecosystems Studies
2016 - Elsevier BV | Biochemical Systematics and Ecology
Tópico(s): Coastal and Marine Management
2016 - Springer Science+Business Media | Environmental Management
Produção Nacional
Revisado por pares
Inês C. Rosa, Rui J. M. Rocha, Ana Rita Lopes, Igor Cristino Silva Cruz, Ricardo Calado, Narcisa M. Bandarra, Ruy Kenji Papa de Kikuchi, Amadeu M.V.M. Soares, João Serôdio, Rui Rosa,
Tópico(s): Coral and Marine Ecosystems Studies
2016 - Springer Science+Business Media | Marine Biology