Lei Hu, Hui Wang, Tingting Xia, Bin Fang, Yu Shen, Qiong Zhang, Xiaohe Tian, Hongping Zhou, Jieying Wu, Yupeng Tian,
... 1, which is lower than that of Kanamycin (Kana, 8 ± 0.42 μg mL-1). Importantly, two-photon imaging and superresolution development of bacterial stain revealed that complex HLSn1 can react with bacterial membranes, producing reactive oxygen species (ROS) and leading to cell death. These outcomes provide ...
Tópico(s): Nanoplatforms for cancer theranostics
2018 - American Chemical Society | Inorganic Chemistry
Tsubasa Abe, Takafumi Yoshioka, Youngseok Song, Tomofumi Tani, Motofumi Kawai, Tsuneaki Omae, Kengo Takahashi, Yoshitaka Takizawa, Tomoko Ro-Mase, Satoshi Ishiko, Kana Minamide, Jun Sakai, Masahiro Akïba, Yohei Hashimoto, Akitoshi Yoshida,
Purpose: The purpose of this study was to evaluate the diagnostic performance of retinal blood flow (RBF) measured with the Doppler optical coherence tomography (OCT) segmental scanning method to distinguish between healthy and glaucoma eyes. Methods: Fifty-eight patients with normal tension glaucoma (NTG) who had a single-hemifield visual field defect and 44 age-matched healthy subjects were enrolled. Retinal nerve fiber layer thickness (RNFLT) was measured with swept-source OCT. Superior and inferior ...
Tópico(s): Retinal Diseases and Treatments
2022 - Association for Research in Vision and Ophthalmology | Translational Vision Science & Technology
Ebenezer Addo Ofori, Asier Garcia-Senosiain, Mohammad Naghizadeh, Ikhlaq Hussain Kana, Morten Hanefeld Dziegiel, Bright Adu, Subhash Singh, Michael Theisen,
Abstract Blood phagocytes, such as neutrophils and monocytes, generate reactive oxygen species (ROS) as a part of host defense response against infections. We investigated the mechanism of Fcγ-Receptor (FcγR) mediated ROS production in these cells to understand how they contribute to anti-malarial immunity. Plasmodium falciparum merozoites opsonized with naturally occurring IgG triggered both intracellular and extracellular ROS generation in blood phagocytes, with neutrophils being the main contributors. ...
Tópico(s): Invertebrate Immune Response Mechanisms
2023 - Nature Portfolio | Communications Biology
Yoshitaka Takizawa, Youngseok Song, Tomofumi Tani, Takafumi Yoshioka, Kengo Takahashi, Tsubasa Abe, Tomoko Ro-Mase, Satoshi Ishiko, Jun Sakai, Kana Minamide, Masahiro Akïba, Takamitsu Tatsukawa, Nobuyoshi Azuma, Akitoshi Yoshida,
Purpose: We aimed to explore the velocity waveform characteristics of the retinal artery associated with age and the cardio-ankle vascular index (CAVI) as a conventional arterial stiffness marker by applying the Doppler optical coherence tomography (DOCT) flowmeter. Methods: In this cross-sectional study, DOCT flowmeter imaging was performed in 66 participants aged 21 to 83 years (17 men, 49 women) with no history of eye diseases and no systemic diseases, except for hypertension. Retinal blood velocity ...
Tópico(s): Cerebrovascular and Carotid Artery Diseases
2021 - Association for Research in Vision and Ophthalmology | Translational Vision Science & Technology
Y Masaki, Lei Dong, Nobuyuki Kurose, K. Kitagawa, Yukie Morikawa, Miho Yamamoto, Hidenobu Takahashi, Yasuhisa Shinomura, Koji Imai, Takako Saeki, Atsushi Azumi, Shinji Nakada, Eiji Sugiyama, Shoko Matsui, Tomoki Origuchi, Susumu Nishiyama, Isao Nishimori, Takayuki Nojima, Ken‐ichi Yamada, Motoko Kawano, Yoh Zen, Masanori Kaneko, Kana Miyazaki, Kazuo Tsubota, Kana Eguchi, Koichi Tomoda, Toshioki Sawaki, Takafumi Kawanami, Makoto Tanaka, Toshihiro Fukushima, S Sugai, Hisanori Umehara,
... and arthralgia, rheumatoid factor and antinuclear, antiSS-A/Ro and antiSS-B/La antibodies was significantly lower ...
Tópico(s): Neuroendocrine Tumor Research Advances
2008 - BMJ | Annals of the Rheumatic Diseases
Kozo Morita, Takeshi Miyamoto, Nobuyuki Fujita, Yoshiaki Kubota, Keisuke Ito, Keiyo Takubo, Kana Miyamoto, Ken Ninomiya, T. Suzuki, Ryotaro Iwasaki, Mitsuru Yagi, Hironari Takaishi, Yoshiaki Toyama, Toshio Suda,
... triggers the process is unknown. Reactive oxygen species (ROS) have been implicated in cellular damage; however, the physiological role of ROS in chondrogenesis is not well characterized. We demonstrate that increasing ROS levels induce chondrocyte hypertrophy. Elevated ROS levels are detected in hypertrophic chondrocytes. In vivo ... In ataxia telangiectasia mutated (Atm)–deficient (Atm−/−) mice, ROS levels were elevated in chondrocytes of growth plates, ... rescued by antioxidant treatment. These findings indicate that ROS levels regulate inhibition of proliferation and modulate initiation ...
Tópico(s): Bone health and treatments
2007 - Rockefeller University Press | The Journal of Experimental Medicine
Keisuke Ito, Keiyo Takubo, Fumio Arai, Hitoshi Satoh, Sahoko Matsuoka, Masako Ohmura, Kazuhito Naka, Masaki Azuma, Kana Miyamoto, Kentaro Hosokawa, Yasuo Ikeda, Tak W. Mak, Toshio Suda, Atsushi Hirao,
... intensively investigated the roles of reactive oxygen species (ROS) in phenotypes of Atm−/− mice. Reduction of ROS by the antioxidant N-acetyl-l-cysteine (NAC) ... Atm−/− mice was mitigated by NAC, indicating that ROS elevation leads to abnormal response to programmed double- ... D)J recombination. We conclude that Atm-mediated ROS regulation is essential for proper DNA recombination, preventing ...
Tópico(s): Effects of Radiation Exposure
2007 - American Association of Immunologists | The Journal of Immunology
Kana Nakanishi, Mitsutoshi Tsukimoto, Sei-ichi Tanuma, Ken Takeda, Shuji Kojima,
... three SNPs for inducing intracellular reactive oxygen species (ROS) production accorded well with those of cytokine production and ATP release. ROS production was inhibited by diphenyleneiodonium chloride (DPI). SNPs, ... inducing ATP release via P2X7 receptor. ATP induces ROS production via NADPH oxidase, and ROS activate inflammasomes, leading to caspase-1-dependent processing ...
Tópico(s): Adenosine and Purinergic Signaling
2016 - Elsevier BV | Toxicology in Vitro
Hann Ling Wong, Reinhard Pinontoan, Kokoro Hayashi, Ryo Tabata, Takashi Yaeno, Kana Hasegawa, Chojiro Kojima, Hirofumi Yoshioka, Koh Iba, Tsutomu Kawasaki, Ko Shimamoto,
Abstract Reactive oxygen species (ROS) produced by NADPH oxidase play critical roles in various cellular activities, including plant innate immunity response. In contrast with the ... Os Rac1) enhanced pathogen-associated molecular pattern–induced ROS production and resistance to pathogens in rice (Oryza ... transient coexpression of Os Rac1 and rbohB enhanced ROS production in Nicotiana benthamiana, suggesting that direct Rac– ...
Tópico(s): Legume Nitrogen Fixing Symbiosis
2007 - Oxford University Press | The Plant Cell
Fumihiko Okumura, Yuha Fujiki, Nodoka Oki, Kana Osaki, Akihiko Nishikimi, Yoshinori Fukui, Kunio Nakatsukasa, Takumi Kamura,
... degradation, which is linked to reactive oxygen species (ROS) production, and the knockdown of KLHDC1 in U2OS ... of SELENOS increased the cell population with lower ROS levels. Our findings reveal that, in addition to ... inactive SELENOS, which would be crucial for maintaining ROS levels and preventing cancer development.
Tópico(s): Ubiquitin and proteasome pathways
2020 - Cell Press | iScience
Kentaro Hosokawa, Fumio Arai, Hiroki Yoshihara, Yuka Nakamura, Yumiko Gomei, Hiroko Iwasaki, Kana Miyamoto, Haruko Shima, Keisuke Ito, Toshio Suda,
... cancer drug, 5-fuluorouracil induces reactive oxygen species (ROS) in HSCs, which suppressed N-cadherin expression. These ... shift from SP cells. These data suggest that ROS suppressed the N-cadherin-mediated cell adhesion, and ...
Tópico(s): Cancer Cells and Metastasis
2007 - Elsevier BV | Biochemical and Biophysical Research Communications
Masanori Obana, Kaori Miyamoto, Shiho Murasawa, Tomohiko Iwakura, Akiko Hayama, Tomomi Yamashita, Momoko Shiragaki, Shohei Kumagai, Akimitsu Miyawaki, Takewaki Kana, Goro Matsumiya, Makiko Maeda, Minoru Yoshiyama, Hiroyuki Nakayama, Yasushi Fujio,
... of metallothionein 1 and 2, reactive oxygen species (ROS) scavengers. Importantly, with the use of cardiac-specific ... injury. Finally, IL-11 failed to suppress the ROS production after I/R in STAT3 CKO mice. ...
Tópico(s): Signaling Pathways in Disease
2012 - American Physical Society | AJP Heart and Circulatory Physiology
Kana Harada, Hiromichi Itoh, Yumi Kawazoe, Shuichi Miyazaki, Kazuya Doi, Takayasu Kubo, Yasumasa Akagawa, Toshikazu Shiba,
... the TRAP-mediated production of reactive oxygen species (ROS), had no effect on such poly(P) degradation, suggesting that the degradation is not dependent on ROS. In addition, shorter chain length poly(P) molecules ...
Tópico(s): Vitamin K Research Studies
2013 - Public Library of Science | PLoS ONE
Yosuke Kaneko, Nobuharu Tanigawa, Yuiko Sato, Tami Kobayashi, Satoshi Nakamura, Eri Ito, Tomoya Soma, Kana Miyamoto, Shu Kobayashi, Kengo Harato, Morio Matsumoto, Masaya Nakamura, Yasuo Niki, Takeshi Miyamoto,
... mechanical stress promotes accumulation of reactive oxygen species (ROS) in chondrocytes in vivo, resulting in chondrocyte apoptosis ... rat model. We demonstrate that mechanical stress induces ROS accumulation and inflammatory cytokine expression in cultured chondrocytes ...
Tópico(s): Inflammatory mediators and NSAID effects
2019 - Nature Portfolio | Scientific Reports
Hitomi Tanaka, Yui Yamashita, Kana Umezawa, Tomohisa Hirobe, Shosuke Ito, Kazumasa Wakamatsu,
... model demonstrated that PM produces reactive oxygen species (ROS) that cause DNA damage and eventually lead to ... large difference was seen in the effects of ROS scavengers, which suggests that the redox reactions may ...
Tópico(s): Olfactory and Sensory Function Studies
2018 - Multidisciplinary Digital Publishing Institute | International Journal of Molecular Sciences
By JOHN A. RAVEN, Andrew Johnston, Richard Parsons, Janet E. Kübler,
... 90)90556-E CASWeb of Science®Google Scholar Kana, T. M.. (1993). Rapid oxygen cycling i. Trichodesmium ... 7924 CASWeb of Science®Google Scholar Marín, A. & Ros, J. D.. (1992). Dynamics of a peculiar plant- ...
Tópico(s): Atmospheric Ozone and Climate
1994 - Wiley | Biological reviews/Biological reviews of the Cambridge Philosophical Society
Vương Cát Khánh, Kinuko Ohneda, Toshiki Kato, Toshiharu Yamashita, Fujio Sato, Kana Tachi, Osamu Ohneda,
... that uremic toxins induced elevated reactive oxygen species (ROS) expression in nAT-MSCs, resulting in the reduced ... imbalance of redox state and high expression of ROS in CKD-AT-MSCs isolated from early-stage ...
Tópico(s): Autophagy in Disease and Therapy
2017 - Mary Ann Liebert, Inc. | Stem Cells and Development
Minoru Narita, Yasuyuki Nagumo, Mayumi Miyatake, Daigo Ikegami, Kana Kurahashi, Tsutomu Suzuki,
... 3‐1‐methyl‐1H‐indol‐3‐ylmaleimide HCl (Ro‐32–0432) into the ventral tegmental area (VTA) ...
Tópico(s): Regulation of Appetite and Obesity
2007 - Wiley | European Journal of Neuroscience
Kana Miyamoto, Kiyomi Y. Araki, Kazuhito Naka, Fumio Arai, Keiyo Takubo, Satoshi Yamazaki, Sahoko Matsuoka, Takeshi Miyamoto, Keisuke Ito, Masako Ohmura, Chen Chen, Kentaro Hosokawa, Hiromitsu Nakauchi, Keiko Nakayama, Keiichi I. Nakayama, Mine Harada, Noboru Motoyama, Toshio Suda, Atsushi Hirao,
... showed increased phosphorylation of p38MAPK, an elevation of ROS, defective maintenance of quiescence, and heightened sensitivity to ...
Tópico(s): Hippo pathway signaling and YAP/TAZ
2007 - Elsevier BV | Cell stem cell
Kazuyoshi Inoue, Toru Takahashi, Kenji Uehara, Hiroko Shimuzu, Kana Ido, Hiroshi Morimatsu, Emiko Omori, Hiroshi Katayama, Reiko Akagi, Kiyoshi Morita,
... HS-hemorrhagic shock; ISOL-in situ oligo ligation; ROS-reactive oxygen species; SnMP-tin-mesoporphyrin
Tópico(s): Thermal Regulation in Medicine
2008 - Lippincott Williams & Wilkins | Shock
Ming Yan, Pei-Ling Luo, Kana Iwakuni, G. Millot, Theodor W. Hänsch, N. Picqué,
Absorption spectroscopy of fundamental ro-vibrational transitions in the mid-infrared region provides a powerful tool for studying the structure and dynamics of molecules in ...
Tópico(s): Photonic and Optical Devices
2017 - Springer Nature | Light Science & Applications
Toshihiko Aki, Kana Unuma, Koichi Uemura,
... damaged mitochondria to prevent the generation of mitochondrial ROS and the initiation of the mitochondrial apoptotic pathway. ...
Tópico(s): Heme Oxygenase-1 and Carbon Monoxide
2017 - Shared Science Publishers OG | Cell Stress
Batbayar Tumurbaatar, Irina Tikhanovich, Zhuan Li, Jinyu Ren, Robert Ralston, Sudhakiranmayi Kuravi, Roosevelt V. Campbell, Gaurav Chaturvedi, Ting‐Ting Huang, Jie Zhao, Junfang Hao, Maura O’Neil, Steven A. Weinman,
... before harvesting. FOXO3−/− mice were provided by Dr. Kana Miyamoto (Keio University, Tokyo, Japan) and were generated ... mitochondrial electron transport and increases reactive oxygen species (ROS) production.J Biol Chem. 2005; 280: 37481-37488Crossref ...
Tópico(s): Liver Disease Diagnosis and Treatment
2013 - Elsevier BV | American Journal Of Pathology
Takuya Ishikawa, Kana Somiya, Reina Munechika, Hideyoshi Harashima, Yuma Yamada,
To achieve mitochondrial gene therapy, developing a mitochondrial transgene expression system that produces therapeutic proteins in mitochondria of disease cells is essential. We previously reported on the design of pCMV-mtLuc (CGG) containing a CMV promotor and a NanoLuc (Nluc) luciferase gene that records adjustments to the mitochondrial codon system, and showed that the mitochondrial transfection of pCMV-mtLuc (CGG) resulted in the efficient production of the Nluc luciferase protein in human HeLa ...
Tópico(s): RNA Interference and Gene Delivery
2018 - Elsevier BV | Journal of Controlled Release
Soumya Saroj, Akshaya Kana Veedu, Chandrasekhar Reddy U, Nalini Venkatesan, Abhishek Kumar Verma, K.M. Muraleedharan,
Tópico(s): Chemotherapy-induced cardiotoxicity and mitigation
2025 - American Chemical Society | ACS Applied Bio Materials
Hiroshi Kobayashi, Kenji Ogawa, Naoki Kawahara, Kana Iwai, Emiko Niiro, Sachiko Morioka, Yuki Yamada,
... be a driving mechanism of reactive oxygen species (ROS)-induced carcinogenesis. HGSC exemplifies the view of stepwise ...
Tópico(s): Endometrial and Cervical Cancer Treatments
2017 - Taylor & Francis | Free Radical Research
Myriam Canonico, Grzegorz Konert, Aurélie Crepin, Barbora Šedivá, Radek Kaňa,
... either in the direct photoprotection (e.g., in ROS scavenging) and/or could play an additional role ...
Tópico(s): Biocrusts and Microbial Ecology
2021 - Multidisciplinary Digital Publishing Institute | Cells
Sho Okubo, Kana Iwakuni, Kōichi Yamada, Hajime Inaba, Atsushi Onae, Feng-Lei Hong, Hiroyuki Sasada,
... we determined the reliable line strength for each ro-vibrational transition as well as the transition dipole ...
Tópico(s): Mass Spectrometry Techniques and Applications
2017 - Elsevier BV | Journal of Molecular Spectroscopy
Yuta Yoshino, Kana Marunaka, Mao Kobayashi, Haruka Matsunaga, Shokoku Shu, Toshiyuki Matsunaga, Akira Ikari,
... nitrogen species (RNS), but not reactive oxygen species (ROS), is stimulated for the mislocalization of claudin-1 ( ...
Tópico(s): Saffron Plant Research Studies
2021 - Multidisciplinary Digital Publishing Institute | International Journal of Molecular Sciences
Hiroyuki Nakamura, Kana Yasufuku, Tomohiko Makiyama, Ikiru Matsumoto, Hiromichi Fujino, Toshihiko Murayama,
... Furthermore, U18666A‐induced formation of reactive oxygen species (ROS) resulted in the induction of cell death and ... plays important roles in the cytotoxicity and the ROS formation in NPC cells. J. Cell. Physiol. 227: ...
Tópico(s): Calcium signaling and nucleotide metabolism
2011 - Wiley | Journal of Cellular Physiology