FROM OUR RACING CORRESPONDENT, FROM OUR SPECIAL CORRESPONDENT, FROM OUR ASSOCIATION FOOTBALL CORRESPONDENT, FROM OUR HOCKEY CORRESPONDENT, FROM OUR BILLIARDS CORRESPONDENT, FROM OUR OWN CORRESPONDENT, FROM OWNERS AND LLOYD'S, W. J. FIRTH., W. T. SULL CLARKE., P. MORLEY HORDER., H. L. NATHAN., CARLO ROSSELLI., A. MACKENZIE LIVINGSTONE., J. B., R. H. ELLIOT., E. GRAHAM-LITTLE., J. M. C., BRUCE BRUCE-PORTER., ROBERT HUTCHISON., FROM A CORRESPONDENT, By CALLISTHENES, By LENNOX ROBINSON, FROM OUR KENNEL CORRESPONDENT, FROM OUR CORRESPONDENT, FROM OUR PARLIAMENTARY CORRESPONDENT, FROM OUR AERONAUTICAL CORRESPONDENT, C. L. HOWARD HUMPHREYS., ULLSWATER., MARGOT OXFORD., BOWERMAN BROTHERS. 11A, Wormwood Street, E.C.2., D. G. SOMERVILLE, M.P., East Willesden. House of Commons, Feb. 20., By William Teeling,
... Bishop Keatinge, Sybil Lady Brassey, Professor F. De Arteaga, Mr. Harold Wright, The Hon. Sydney Smith, Major ...
1934 - Gale Group | TDA
Produção Nacional
Revisado por pares
Isaac Josh Abecassis, Vasu Saini, Timothy J. Phillips, Joshua W. Osbun, Mario Martínez‐Galdámez, Ahmed Nada, Michael R. Levitt, R. Webster Crowley, Mithun G. Sattur, Alejandro M Spiotta, Evan Luther, Stephanie H. Chen, Joshua D. Burks, Pascal Jabbour, Ahmad Sweid, Marios Psychogios, Min S. Park, Dileep R. Yavagal, Eric C. Peterson, Muhammad Waqas, Rimal H. Dossani, Jason M. Davies, Alex Brehm, Gregory D. Selkirk, W. Christopher Fox, Daniel Giansante Abud, Jorge Galván Fernández, Miguel Schüller Arteaga, Robert M. Starke,
Radial artery access for transarterial procedures has gained recent traction in neurointerventional due to decreased patient morbidity, technical feasibility, and improved patient satisfaction. Upper extremity transvenous access (UETV) has recently emerged as an alternative strategy for the neurointerventionalist, but data are limited. Our objective was to quantify the use of UETV access in neurointerventions and to measure failure and complication rates.An international multicenter retrospective ...
Tópico(s): Venous Thromboembolism Diagnosis and Management
2021 - BMJ | Journal of NeuroInterventional Surgery
Keith T. Flaherty, Robert J. Gray, Alice Chen, Shuli Li, Lisa M. McShane, David R. Patton, Stanley R. Hamilton, P. Mickey Williams, A. John Iafrate, Jeffrey Sklar, Edith P. Mitchell, Lyndsay N. Harris, Naoko Takebe, David Sims, Brent Coffey, Tony Fu, Mark J. Routbort, James A. Zwiebel, Larry Rubinstein, Richard F. Little, Carlos L. Arteaga, Robert L. Comis, Jeffrey S. Abrams, Peter J. O’Dwyer, Barbara A. Conley,
Therapeutically actionable molecular alterations are widely distributed across cancer types. The National Cancer Institute Molecular Analysis for Therapy Choice (NCI-MATCH) trial was designed to evaluate targeted therapy antitumor activity in underexplored cancer types. Tumor biopsy specimens were analyzed centrally with next-generation sequencing (NGS) in a master screening protocol. Patients with a tumor molecular alteration addressed by a targeted treatment lacking established efficacy in that ...
Tópico(s): Colorectal Cancer Treatments and Studies
2020 - Lippincott Williams & Wilkins | Journal of Clinical Oncology
Danny Arteaga, Robert Cotta, Alejandro Ortíz, Braulio Insuasty, Nazario Martı́n, Luís Echegoyen,
Herein we report the design, synthesis, and characterization of a series of new organic dyes, as well as their application in dye-sensitized nanocrystalline TiO2 solar cells. In the designed dyes, the diphenylamine Zn(II) porphyrin group plays the role of the core electron donor unit and the cyanoacrylic acid, rhodanine acetic acid, and dicyanorhodanine groups are the acceptors. These electroactive units are linked by either vinyl-fluorene or vinyl-thiophene spacer units. To study the electron distribution ...
Tópico(s): Porphyrin and Phthalocyanine Chemistry
2014 - Elsevier BV | Dyes and Pigments
Jennifer B. Dennison, Jennifer R. Molina, Shreya Mitra, Ana M. González-Angulo, Justin M. Balko, María G. Kuba, Melinda E. Sanders, Joseph A. Pinto, Henry Gómez, Carlos L. Arteaga, Robert Brown, Gordon B. Mills,
Abstract Purpose: Although breast cancers are known to be molecularly heterogeneous, their metabolic phenotype is less well-understood and may predict response to chemotherapy. This study aimed to evaluate metabolic genes as individual predictive biomarkers in breast cancer. Experimental Design: mRNA microarray data from breast cancer cell lines were used to identify bimodal genes—those with highest potential for robust high/low classification in clinical assays. Metabolic function was evaluated ...
Tópico(s): Cancer Cells and Metastasis
2013 - American Association for Cancer Research | Clinical Cancer Research
Jaimee L. Heffner, Theodore C. Lee, Carmen Arteaga, Robert M. Anthenelli,
Identifying predictors of smoking relapse helps to elucidate the challenges of long-term smoking cessation and provides direction for improved treatment development. In this post hoc data analysis, we examined predictors of relapse from end-of-treatment (week 13) through 1-year follow-up (week 52) for treatment-responding participants who achieved the primary efficacy endpoint of 4-week continuous abstinence (weeks 9–12), during two phase III varenicline trials. Of 626 smokers classified as treatment ...
Tópico(s): Substance Abuse Treatment and Outcomes
2010 - Elsevier BV | Drug and Alcohol Dependence
Eugenio Arteaga, Robert F. Klein, Edward G. Biglieri,
Angiotensin II has a major effect on mineralocorticoid hormone synthesis in patients with idiopathic hyperaldosteronism; it has little or no effect in those with an aldosterone-producing adenoma. To determine if this difference could be of use in clinically separating these two forms of primary aldosteronism, saline infusion tests were performed in 20 patients—14 with surgically proved aldosterone-producing adenoma and six with Idiopathic hyperaldosteronism. With the patients receiving a balanced ...
Tópico(s): Adrenal Hormones and Disorders
1985 - Elsevier BV | The American Journal of Medicine
Carlos L. Arteaga, Robert J. Coffey,
Desmoplasia, the formation of highly cellular, excessive connective tissue stroma associated with some cancers, shares many features with the wound healing response. Since connective tissue growth factor (CTGF) has previously been demonstrated to play a role in wound repair, we wanted to determine if it might be involved in the pathogenesis of stromal desmoplasia in mammary cancer. We assayed 11 human invasive mammary ductal carcinomas by Northern blot and 7 out of 11 were positive for both CTGF ...
Tópico(s): Wnt/β-catenin signaling in development and cancer
1992 - Elsevier BV | Human Pathology
Lindsey Drake, Allen F. Brooks, Jenelle Stauff, Phillip Sherman, Janna Arteaga, Robert A. Koeppe, Aimee Reed, Timothy J. Montavon, Marc B. Skaddan, Peter J. H. Scott,
The implication of the receptor for advanced glycation end-products (RAGE) in numerous diseases and neurodegenerative disorders makes it interesting both as a therapeutic target and as an inflammatory biomarker. In the context of investigating RAGE as a biomarker, there is interest in developing radiotracers that will enable quantification of RAGE using positron emission tomography (PET) imaging. We have synthesized potential small molecule radiotracers for both the intracellular ([
Tópico(s): Fatty Acid Research and Health
2020 - Elsevier BV | Journal of Pharmaceutical Analysis
Elkin Garcia, Jaime Muñoz Arteaga, Robert Pavel, Guang R. Gao,
Power consumption and energy efficiency have become a major bottleneck in the design of new systems for high performance computing. The path to exa-scale computing requires new strategies that decrease the energy consumption of modern many-core architectures without sacrificing scalability or performance. The development of these strategies demands the use of scalable models for energy consumption and the reorientation of optimization techniques to focus on energy efficiency, evaluating their trade- ...
Tópico(s): Advanced Data Storage Technologies
2014 - Springer Science+Business Media | Lecture notes in computer science
Keith T. Flaherty, Robert J. Gray, Alice Chen, Shuli Li, David R. Patton, Stanley R. Hamilton, P. Mickey Williams, Edith P. Mitchell, A. John Iafrate, Jeffrey Sklar, Lyndsay N. Harris, Lisa M. McShane, Larry Rubinstein, David Sims, Mark Routbort, Brent Coffey, Tony Fu, James A. Zwiebel, Richard F. Little, Donna M. Marinucci, Robert B. Catalano, Rick Magnan, Warren A. Kibbe, Carol J. Weil, James V. Tricoli, Brian M. Alexander, Shaji Kumar, Gary K. Schwartz, Funda Meric‐Bernstam, Chih‐Jian Lih, Worta McCaskill‐Stevens, Paolo F. Caimi, Naoko Takebe, Vivekananda Datta, Carlos L. Arteaga, Jeffrey S. Abrams, Robert L. Comis, Peter J O’Dwyer, Barbara A. Conley,
Abstract Background The proportion of tumors of various histologies that may respond to drugs targeted to molecular alterations is unknown. NCI-MATCH, a collaboration between ECOG-ACRIN Cancer Research Group and the National Cancer Institute, was initiated to find efficacy signals by matching patients with refractory malignancies to treatment targeted to potential tumor molecular drivers regardless of cancer histology. Methods Trial development required assumptions about molecular target prevalence, ...
Tópico(s): Statistical Methods in Clinical Trials
2020 - Oxford University Press | JNCI Journal of the National Cancer Institute
Jennifer I. Lim, Lindsay Machen, Andrea Arteaga, Faris I. Karas, Robert A. Hyde, Dingcai Cao, Marcia Niec, Thasarat S. Vajaranant, M. Soledad Cortina,
Purpose: To determine whether 1-year visual and anatomical results after surgery combining pars plana vitrectomy, Boston keratoprosthesis, and a glaucoma drainage device as needed are similar, better, or worse than Boston keratoprosthesis initial implantation alone. Methods: We performed a retrospective review of adult patients undergoing Boston keratoprosthesis at our institution. Visual acuity outcomes, anatomical results, and complication rates of patients undergoing combination surgery (including ...
Tópico(s): Intraocular Surgery and Lenses
2018 - Lippincott Williams & Wilkins | Retina
Tobias D. Schneider, José M. Arteaga-Salas, Edith Mentele, Robert David, Dario Nicetto, Axel Imhof, Ralph A.W. Rupp,
Vertebrate embryos are derived from a transitory pool of pluripotent cells. By the process of embryonic induction, these precursor cells are assigned to specific fates and differentiation programs. Histone post-translational modifications are thought to play a key role in the establishment and maintenance of stable gene expression patterns underlying these processes. While on gene level histone modifications are known to change during differentiation, very little is known about the quantitative ...
Tópico(s): RNA Research and Splicing
2011 - Public Library of Science | PLoS ONE
Hanh H. Garcia, Gloria A. Brar, David H.H. Nguyen, Leonard F. Bjeldanes, Gary L. Firestone,
... PubMed Scopus (59) Google Scholar, 51Brown K.A. Roberts R.L. Arteaga C.L. Law B.K. Breast Cancer Res. ...
Tópico(s): Genomics, phytochemicals, and oxidative stress
2004 - Elsevier BV | Journal of Biological Chemistry
Anna Chytil, Mary Waltner‐Law, Robert B. West, David J. Friedman, Mary Aakre, Dana Barker, Brian K. Law,
... PubMed Scopus (90) Google Scholar, 24Brown K.A. Roberts R.L. Arteaga C.L. Law B.K. Breast Cancer Res. ...
Tópico(s): DNA Repair Mechanisms
2004 - Elsevier BV | Journal of Biological Chemistry
Barbara A. Conley, Robert J. Gray, Alice Chen, Peter J. O’Dwyer, Carlos L. Arteaga, Brent Coffey, David R. Patton, Shuli Li, Lisa M. McShane, Larry Rubinstein, Robert L. Comis, Jeffrey Abrams, P. Mickey Williams, Chih‐Jian Lih, Stanley R. Hamilton, Edith Mitchell, James A. Zwiebel, Keith T. Flaherty,
... Robert Gray, Alice Chen, Peter O’Dwyer, Carlos Arteaga, Brent Coffey, David Patton, Shuli Li, Lisa M. McShane, Larry Rubinstein, Robert Comis, Jeffrey Abrams, Paul M. Williams, Chih-Jian ...
Tópico(s): Lung Cancer Treatments and Mutations
2016 - American Association for Cancer Research | Cancer Research
Harikiran Nistala, Sui Lee‐Arteaga, Silvia Smaldone, Gabriella Siciliano, Luca Carta, Robert N. Ono, Gerhard Sengle, Emilio Arteaga‐Solis, Régis Levasseur, Patricia Ducy, Lynn Y. Sakai, Gérard Karsenty, Francesco Ramirez,
Extracellular regulation of signaling by transforming growth factor (TGF)–β family members is emerging as a key aspect of organ formation and tissue remodeling. In this study, we demonstrate that fibrillin-1 and -2, the structural components of extracellular microfibrils, differentially regulate TGF-β and bone morphogenetic protein (BMP) bioavailability in bone. Fibrillin-2–null (Fbn2−/−) mice display a low bone mass phenotype that is associated with reduced bone formation in vivo and impaired osteoblast ...
Tópico(s): Bone and Dental Protein Studies
2010 - Rockefeller University Press | The Journal of Cell Biology
Eugenio Arteaga, Robert F. Klein, Edward G. Biglieri,
No AccessJournal of UrologyMetabolism, Endocrinology and Immunology1 Jun 1986Use of the Saline Infusion Test to Diagnose the Cause of Primary Aldosteronism E. Arteaga, R. Klein, and E.G. Biglieri E. ArteagaE. Arteaga More articles by this author , R. KleinR. Klein More articles by this author , and E.G. BiglieriE.G. Biglieri More articles by this author View All Author Informationhttps://doi.org/10.1016/S0022-5347(17)46125-8AboutPDF ToolsAdd to favoritesDownload CitationsTrack CitationsPermissionsReprints ...
Tópico(s): Vitamin K Research Studies
1986 - Lippincott Williams & Wilkins | The Journal of Urology
Jhonathan Pazmiño-Arteaga, Cecilia Gallardo, Tzitziki González-Rodríguez, Robert Winkler,
Tópico(s): Organic Food and Agriculture
2022 - Springer Science+Business Media | Plant Foods for Human Nutrition
Gabrielle R. Budziszewski, Yani Zhao, Cathy J. Spangler, Katarzyna M. Kedziora, Michael R. Williams, Dalal N. Azzam, Aleksandra Skrajna, Yuka Koyama, Andrew P. Cesmat, Holly C. Simmons, Eyla C. Arteaga, Joshua D. Strauss, Dmitri Kireev, Robert K. McGinty,
A key role of chromatin kinases is to phosphorylate histone tails during mitosis to spatiotemporally regulate cell division. Vaccinia-related kinase 1 (VRK1) is a serine-threonine kinase that phosphorylates histone H3 threonine 3 (H3T3) along with other chromatin-based targets. While structural studies have defined how several classes of histone-modifying enzymes bind to and function on nucleosomes, the mechanism of chromatin engagement by kinases is largely unclear. Here, we paired cryo-electron ...
Tópico(s): Virus-based gene therapy research
2022 - Oxford University Press | Nucleic Acids Research
Lorenzo Cobianchi, Francesca Dal Mas, Maurizio Massaro, Paola Fugazzola, Federico Coccolini, Yoram Kluger, Ari Leppäniemi, Ernest E. Moore, Massimo Sartelli, Peter Angelos, Fausto Catena, Luca Ansaloni, Abubaker Abdelmalik, Nebyou Seyoum Abebe, Fikri M. Abu‐Zidan, Yousif Abdallah Yousif Adam, Harissou Adamou, Antonino Agrusa, Emrah Akın, Henrique Alexandrino, Syed Muhammad Ali, Pedro Miguel Almeida, Francesco Amico, Michele Ammendola, Jacopo Andreuccetti, Daniel Aparicio-Sánchez, Antonella Ardito, Giulio Argenio, Ingolf Askevold, Boyko Atanasov, Goran Augustin, Selmy Awad, Carlo Bagnoli, Lovenish Bains, Dimitrios Balalis, Edoardo Baldini, Oussama Baraket, Mirko Barone, Jorge Arturo Barreras, Giovanni Bellanova, Helena Biancuzzi, Mark Brian Bignell, Roberto Bini, Daniele Bissacco, Paoll Boati, Andrea Bottari, Konstantinos Bouliaris, Antonio Brillantino, Luis Antonio Buonomo, Salvatore Buscemi, Valentin Calu, Riccardo Campo Dall′Orto, João Carvas, Gianmaria Casoni Pattacini, Valerio Celentano, Marco Ceresoli, Mircea Chirica, Pasquale Cianci, Nicola Cillara, Stefania Cimbanassi, Stefano Piero Bernardo Cioffi, Elif Çolak, Luigi Conti, Silvia Dantas Costa, Fabrizio D’Acapito, Dimitrios Damaskos, Koray Daş, Richard Justin Davies, Andrew Charles de Beaux, Belinda De Simone, Zaza Demetrashvili, Andreas K. Demetriades, Stefano Denicolai, Giuseppe Di Buono, Isidoro Di Carlo, Salomone Di Saverio, Bogdan Diaconescu, Rigers Dibra, Sandra Dios‐Barbeito, Agron Dogjani, Maurizio Domanin, Mario D’Oria, Virginia Duran Munoz-Cruzado, Barbora East, Gerald Ekwen, Adel Elbaih, Juan Pablo Escalera-Antezana, Giuseppe Esposito, Roser Farré, Antonjacopo Ferrario di Tor Vajana, Vinicius Cordeiro Fonseca, Francesco Forfori, Laura Fortuna, Εvangelos C. Fradelos, Gustavo Pereira Fraga, Pietro Fransvea, Mahir Gachabayov, Alain García Vázquez, Wagih Ghannam, Rossella Gioco, Giorgio Giraudo, Mario Giuffrida, M Capponi, Carlos Augusto Gomes, Ricardo Alessandro Teixeira Gonsaga, Emre Gönüllü, Jacques Goosen, Tatjana Goranović, Ewen A. Griffiths, Muad Gamil Haidar, Hytham K. S. Hamid, Timothy Craig Harddastle, Matthias Hecker, Edgar Fernando Hernandez García, Eduardo Cancio Huaman, M Hut'an, Orestis Ioannidis, Arda Işık, Azzain Mahadi Hamid Ismail, Nizar Ismail, Ji Young Jang, Sujala Niatarika Rajsain Kalipershad, Lewis J. Kaplan, Yasi̇n Kara, Evika Karamagioli, Aleksandar Karamarkovia, Alfie J. Kavalakat, Aristotelis Kechagias, Jakub Kenig, Jim Khan, Vladimir Khokha, Roberto Klappenbach, Roberto Klappenbach, Yoshiro Kobe, Victor Kong, Dimitrios Korkolis, Hayato Kurihara, Akira Kuriyama, Aitor Landaluce-Olavarria, Leslie Claire Licari, Andrey Litvin, Varut Lohsiriwat, Claudia Cristina Lopes Moreira, Eftychios Lostoridis, Agustín Tovar Luna, Davide Luppi, Gustavo M. Machaín, Marc Maegele, D Maggiore, Ronald V. Maier, Mallikarjuna Manangi, andrea manetti, Barış Mantoğlu, Federico Mariani, Athanasios Marinis, Evandro Antonio Sbalcheiro Mariot, Gennaro Martines, Aleix Martinez Perez, Pietro Mascagni, Damien Massalou, Renato Bessa Melo, Luca Miceli, Andrea Mingoli, Tushar Subhadarshan Mishra, Ali Yasen Mohamedahmed, Rajashekar Mohan, Dieter Morales-García, Sami Mohamed Siddig Mustafa, Mukhammad David Naimzada, Ionut Negoi, Melkamu Kibret Nidaw, Giuseppe Nigri, H D Ogundipe, Cristina Oliveri, Stefano Olmi, Léonardo Pagani, Giuseppe Palomba, D Pantalone, Arpád Panyko, Ciro Paolillo, Davide Papis, Νικόλαος Παραράς, Francesco Pata, Giovanna Pavone, Francesca Pecchini, Gianluca Pellino, María Pelloni, Andrea Peloso, Eduardo Perea del Pozo, Rita Goncalves Pereira, Bruno Monteiro Pereira, Aintzane Lizarazu, Gennaro Perrone, Antonio Pesce, Giovanni Petracca, Micaela Piccoli, Edoardo Picetti, Emmanouil Pikoulis, Tadeja Pintar, Giovanni Pirozzolo, Mauro Podda, Pietro Previtali, Francesca Privitera, Clelia Punzo, Martha Quiodettis, Niels Qvist, Razrim Rahim, Alexander Reinisch, María Rita Rodríguez‐Luna, Daniel Roizblatt, Francesco Roscio, Stefano Rossi, Boris Sakakushev, Juan Carlos Salamea, Ibrahima Sall, Fabrizio Sammartano, Alejandro Sánchez Arteaga, Sergio Sánchez-Cordero, Diego Sasia, Robert G. Sawyer, Charalampos Seretis, Mario Serradilla‐Martín, Vishal G. Shelat, S. A. Shlyapnikov, Romeo Lages Simoes, Boonying Siribumrungwong, Mihail Slavchev, Leonardo Solaini, Gabriele Soldini, Kjetil Søreide, Larysa Sydorchuk, Ruslan Sydorchuk, Ali Syed, Luis Tallón‐Aguilar, Jih Huei Tan, Antonio Tarasconi, Dario Tartaglia, Nicola Tartaglia, John V. Taylor, Giovanni Domenico Tebala, Ricardo Alessandro Teixeira Gonsaga, Michel Teuben, Matti Tolonen, G. Tomasicchio, Tania Triantafyllou, Giuseppe Trigiante, Víctor Turrado-Rodríguez, Roberta Tutino, Matteo Uccelli, Bakarne Ugarte-Sierra, Mika Ukkonen, Pantelis Vassiliu, Juan M. Verde, Massimiliano Veroux, Ramón Vilallonga, Diego Visconti, Maciej Wałędziak, Tongporn Wannatoop, Lukas Werner Widmer, Michael Wilson, Ting Hway Wong, Sofia Xenaki, Byungchul Yu, Andee Dzulkarnaen Zakaria, Diego Zambrano, Monica Zese,
Emergency surgery represents a unique context. Trauma teams are often multidisciplinary and need to operate under extreme stress and time constraints, sometimes with no awareness of the trauma's causes or the patient's personal and clinical information. In this perspective, the dynamics of how trauma teams function is fundamental to ensuring the best performance and outcomes.An online survey was conducted among the World Society of Emergency Surgery members in early 2021. 402 fully filled questionnaires ...
Tópico(s): Simulation-Based Education in Healthcare
2021 - BioMed Central | World Journal of Emergency Surgery
Carlos L. Arteaga, K Koli, Teresa C. Dugger, Robert Clarke,
BACKGROUND: Overexpression of transforming growth factor (TGF)-β has been reported in human breast carcinomas resistant to antiestrogen tamoxifen, but the role of TGF-β in this resistant phenotype is unclear. We investigated whether inhibition of TGF-β2, which is overexpressed in LCC2 tamoxifen-resistant human breast cancer cells, could modify antiestrogen resistance. METHODS: TGF-β2 expression was evaluated in LCC2 cells and tamoxifen-sensitive LCC1 cells by northern blot analysis. Secreted TGF- ...
Tópico(s): Reproductive System and Pregnancy
1999 - Oxford University Press | JNCI Journal of the National Cancer Institute
Kimberly Brown, Richard Roberts, Carlos L. Arteaga, Brian K. Law,
The transforming growth factor-β (TGF-β) signaling pathway functions to prevent tumorigenesis, and loss of sensitivity to TGF-β-mediated cell cycle arrest is nearly ubiquitous among human cancers. Our previous studies demonstrated that rapamycin potentiates TGF-β-induced cell cycle arrest in nontransformed epithelial cells and partially restores TGF-β-induced growth arrest of some human cancer cell lines. Growth arrest correlated with increased binding of p21 and p27 to cyclin-dependent kinase-2 ( ...
Tópico(s): Pancreatic and Hepatic Oncology Research
2004 - BioMed Central | Breast Cancer Research
Reade B. Roberts, Carlos L. Arteaga, David W. Threadgill,
Current trends foretell the use of cancer treatments customized to each patient. Genetic and molecular profiling of tumors and an increasing number of molecule-targeted therapies contribute to making this a reality. However, as targets of anticancer therapies become specific proteins or pathways, unanticipated side effects may emerge. In addition, the chronic use of these treatments may contribute to the development of degenerative toxicity not predicted by short-term clinical trials. Here we review ...
Tópico(s): Ubiquitin and proteasome pathways
2004 - Cell Press | Cancer Cell
G C Xakellis, Robert Frantz, M Arteaga, Steven Meletiou,
This study compared the dermal blood flow response to low levels of compressive pressure in healthy older and younger subjects. Dermal blood flow was measured over the left trochanter of 19 younger (21-45 yrs) and 22 older (> or = 60 yrs) subjects using a laser-Doppler velocitometer. Interface pressure, baseline flow, and flow during 60 minutes of left-side lying on an air mattress were measured. Baseline dermal blood flow did not differ significantly between the older and younger groups. Both groups ...
Tópico(s): Thermoregulation and physiological responses
1993 - Oxford University Press | Journal of Gerontology
Kathleen Ward, Oluwaseun Falade‐Nwulia, Juhi Moon, Catherine G. Sutcliffe, Sherilyn Brinkley, Taryn Haselhuhn, Stephanie Katz, Kayla Herne, Lilian Arteaga, Shruti H. Mehta, Carl A. Latkin, Robert K. Brooner, Mark Sulkowski,
Despite access to direct-acting antivirals, barriers to a hepatitis C virus (HCV) cure persist, especially among persons living with human immunodeficiency virus (HIV) (PLWH) who use drugs. Interventions such as peer mentors or cash incentives may improve the care continuum. The CHAMPS (Chronic HepAtitis C Management to ImProve OutcomeS) study randomized 144 PLWH, recruited from an outpatient clinic, with substance use disorders into three treatment groups: usual care (UC) (n = 36), UC plus cash incentives ( ...
Tópico(s): HIV-related health complications and treatments
2019 - Oxford University Press | Open Forum Infectious Diseases
Beata M. Wolska, Kalpana Vijayan, Grace M. Arteaga, John P. Konhilas, Ronald M. Phillips, Robert Kim, Taihei Naya, Jeffrey M. Leiden, Anne F. Martin, Pieter P. de Tombe, R. John Solaro,
1 Acidosis in cardiac muscle is associated with a decrease in developed force. We hypothesized that slow skeletal troponin I (ssTnI), which is expressed in neonatal hearts, is responsible for the observed decreased response to acidic conditions. To test this hypothesis directly, we used adult transgenic (TG) mice that express ssTnI in the heart. Cardiac TnI (cTnI) was completely replaced by ssTnI either with a FLAG epitope introduced into the N-terminus (TG-ssTnI*) or without the epitope (TG-ssTnI) in ...
Tópico(s): Viral Infections and Immunology Research
2001 - Wiley | The Journal of Physiology
María V. de la Cruz, Manuel Arteaga, Jorge Espino‐Vela, M Quero-Jiménez, Robert H. Anderson, Gabriel Díaz,
Tópico(s): Coronary Artery Anomalies
1981 - Elsevier BV | American Heart Journal
Pravat Kumar Parida, Mauricio Marquez-Palencia, Vidhya R. Nair, Akash Kaushik, Kangsan Kim, Jessica Sudderth, Eduardo Quesada-Diaz, Ámbar Cajigas, Vamsidhara Vemireddy, Paula I. González-Ericsson, Melinda E. Sanders, Bret C. Mobley, Kenneth E. Huffman, Sunati Sahoo, Prasanna Alluri, Cheryl Lewis, Yan Peng, Robert Bachoo, Carlos L. Arteaga, Ariella B. Hanker, Ralph J. DeBerardinis, Srinivas Malladi,
HER2+ breast cancer patients are presented with either synchronous (S-BM), latent (Lat), or metachronous (M-BM) brain metastases. However, the basis for disparate metastatic fitness among disseminated tumor cells of similar oncotype within a distal organ remains unknown. Here, employing brain metastatic models, we show that metabolic diversity and plasticity within brain-tropic cells determine metastatic fitness. Lactate secreted by aggressive metastatic cells or lactate supplementation to mice bearing ...
Tópico(s): Lung Cancer Research Studies
2022 - Cell Press | Cell Metabolism
David P. Kodack, Vasileios Askoxylakis, Gino B. Ferraro, Qing Sheng, Mark Badeaux, Shom Goel, Xiaolong Qi, Ram C. Shankaraiah, Zheng Cao, Rakesh R. Ramjiawan, Divya Bezwada, Bhushankumar Patel, Yongchul Song, Carlotta Costa, Kamila Naxerova, Christina S.F. Wong, Jonas Kloepper, Rita Das, Angela Tam, Jantima Tanboon, Dan G. Duda, C. Ryan Miller, Marni B. Siegel, Carey K. Anders, Melinda E. Sanders, Mónica V. Estrada, Robert Schlegel, Carlos L. Arteaga, Elena F. Brachtel, Alan Huang, Dai Fukumura, Jeffrey A. Engelman, Rakesh K. Jain,
Although targeted therapies are often effective systemically, they fail to adequately control brain metastases. In preclinical models of breast cancer that faithfully recapitulate the disparate clinical responses in these microenvironments, we observed that brain metastases evade phosphatidylinositide 3-kinase (PI3K) inhibition despite drug accumulation in the brain lesions. In comparison to extracranial disease, we observed increased HER3 expression and phosphorylation in brain lesions. HER3 blockade ...
Tópico(s): Advanced Breast Cancer Therapies
2017 - American Association for the Advancement of Science | Science Translational Medicine