Jonathan Northcroft, Tracey Boles, Patrick Cooper, John Dugdale, William Kay, Barbara Hall, Zinedine Zidane, Rob Kingston, Fred Redwood, John-Paul Flintoff, Newby Hands, Sally Brock, Helen Davies, Peter Whittle, Robert Muir, Nicholas Rufford, Rob Hughes, Leslie Phillips, Denise O'Leary, A Burgess, Iain Chapman, Jasper Rees, Anthony Rhodes, James Fuller, Andrew Longmore, John Waples Business Editor, Neil …, Thomas Stapleton, Susan d'Arcy, Ian Marchant, Widiane Moussa, Gareth Walsh, Frank Whitford, Rachel de Thame, Ken Johnston, Andrew Ledingham, Nicolette Jones, David Gower, Paul Marinko, Alan M Rind, Andrew Taylor, P D, David Smith, Joshua Robinson, Nick Pitt, Susie Whalley, E P, Alison Kervin, Andrew Sullivan, Clive Davis, David P Morgan, Joe Lauria, David Simmons, Flora Bagenal, Martin Jol, Joseph Dunn, Martin James, Simon Wilde, Sara Hashash, Paul Beaver, Carolyn Wright Principal, Sally De Witt, June Greenfield, Ariel Leve, Robert Winnett, Robert Sandall, Irwin Stelzer, Matt Rudd, Robert Hewison, Peter Wilson, Rosie Millard, Bob Russell MP, David Dougill, C H, John Arlidge, Christopher Hart, John Bryant, Dave Riley, Paul Flynn, Cally Law, Paul Forsyth, Hugh Canning, Isabel Oakeshott, Jeremy Clarkson, Dave Crandall, Edward Porter, David Cairns, Stewart Lee, Nicola Smith, Claire Newell, Michael Portillo, Dean Nelson, Tim Huffer, Alan Williams, Ed Mayo, Nick Middleton, Patricia Nicol, Sarah Dempster, Dave Pollard, Anita Chaudhuri, Robert Pires, Gill Chant, Richard Fletcher, McIlvanney, Greg Struthers, Yuha Bessaoud, John Cuthbertson, Sunil Pal, Sarah-Kate Templeton Health Correspondent, Holly Watt, Rosanna Della Corte, Jeff Porter, Mark Heath, Stuart Wavell, Roger Eglin, Paul Donovan, Sarah Bailey, Bruce Sher, Graham Collins, Vincent Crump, Paul Kimmage, Tom Stubbs, Hugh McIlvanney, Chris Woodhead, Monsieur Mangetout, Steve McClaren, Bridget Stott, Jasper Gerard, Paul Driver, Michael Woodhead, Giles Hattesley, John Follain, Richard Brooks, Steve Lunt, Ian Hawkey, Jon Phillips Communications Director, Stuart Andrews, Christopher Morgan, David Leppard, Shelley Von Strunckel, Paul Durman, Gavin Bell, Jeff Hall, Harald Doornbos, Mark Edwards, Rachel Bridge, Nick Doff, Sophie Anderton, Heston Blumenthal, David Miller, Brian McCullough, Christina Lamb, Lois Rogers, Donald MaCkay, Gerrard Abel, Raymond Keene, C L, Gareth Huw Davies, Rod Liddle, Alex Delmar-Morgan, Harold Reiter, David Cracknell, Cosmo Landesman, Zoe Brennan, Marie Colvin, Paul Hughes, Gavin Conway, Edward Wheatley, T Carter, Bob Edwards, Dominic O'Connell, A C Watt, David Phelan, Louise Armitstead, Mat Snow, Adrienne Connors, Lucy Atkins, Margaret Aitchison, Tim Moorey, Caroline Donald, Barry Mason, Aidan Doran, Barry Flatman Tennis Correspondent, Alan Buck, Colin McDowell, Bryan Appleyard, Jennifer Harper-Deacon, Stephen Armstrong, John Elliott, James Taylor, Isabel Oakeshott Deputy Political Editor, Bethan Cole, Michael Sheridan Far East Correspondent, Richard Woods, Roland White, Ed Carlisle, Steven Swinford, Alison Jane Reid, J Higgins, Rolf Harris, Shane Watson, Maurice Chittenden, Graham Ede, Richard Brooks Arts Editor, Dr Mohmmed Wajed, Richard Rae, Mark Franchetti, Ray Hutton, Sarah Beeny, Jon Ungoed-Thomas, Martin Ivens, Louise Armistead, Richard Corrigan's, Jonathan Leake, Katharine Hibbert, Clare Francis, Michael Smith, John Harlow, Denis Knowles, D G Shute, Chris Haslam, Dipesh Gadher, Claudio Franco, Mark Kleinman, Oliver Chastney, St John Brown, A A Gill, Matthew Campbell, Ross Manning, Daniel Foggo, Brian Glanville, Simon Jenkins, Stephen Pettitt, Will Iredale, Jonathan Calvert, Jonathan Leake Science Editor, Jessica Bown, Imre Karacs, Sally Kinnes, Daniel Emery, Jonathan Simms, Sir Peter Lampl Chairman, Peter Done managing director, Brian Doogan, John Aizlewood, John Cornwell, Simon Kurs, James Scoltock, Peter Goves, Joe Lovejoy, Ian Ogden, Jonathan Futrell, Andrew Frankel, David Budworth, Hugh Pearman, Graham Norwood, Andrew Davidson, Dan Cairns, Julian Ryall, Ed Habershon, David Smith Economics Editor, Sue Nelson, Sarah Baxter, Brian Schofield, Kate Spicer, Joanna Simon, India Knight, Tony Fazackerley, Simon Wilde Cricket Correspondent, Ed Hughes, Simon Howard, Jason Dawe, Joan Smith, Richard Lewis, Sian Griffiths, Karen Robinson, Helen Stewart,
... a city scarred by civil war, asks Harald Doornbos Savills Multiple Display Advertising Items Pure Barclays Multiple ... the impresario Sally Greene avoiding the limelight? By Robert Sandall. Portraits by Howard Sooley Bordeaux Birds Eye ...
2006 - Gale Group | Sunday Times HA GDA
Anja J. Doornbos, Robert‐Jan Simons, Eddie Denessen,
Abstract Some organizations seek to promote informal work‐related learning to stimulate organizational performance. This study focuses on six types of work‐related learning in relation to personal, relational, and work characteristics of the workplace practice. A survey was conducted to identify types and levels of work‐related learning for executive Dutch police officers in terms of intentionality, developmental relatedness, and interaction partner's professional practice and hierarchical position. ...
Tópico(s): Human Resource Development and Performance Evaluation
2008 - Wiley | Human Resource Development Quarterly
Joanna Russell, Taki, Alix Cull, Waldemar Januszczak, John Dugdale, Barney Spender, Matthew Wall, Iris Murdoch, Dr Dolittle, Judith O'Reilly Education Correspondent, Lucas Hollweg, Christopher Morgan Religious Affairs Correspondent, Barbara Hall, Brian Collett, Jon Swain, John Peter, Pam Barrett, Emma Moore, Nick Bradshaw, Jonathan Miller, Lesley White, John Jay, Susan d'Arcy, Emine Saner, Inigo Gilmore, Frank Whitford, Natasha Woods, Sam Gilpin, Addison de Witt, Sally O'Reilly, Sally Payne, David Smith, Kirstie Hamilton City Editor, Kenneth Rose, Neil Wormald, Beverley D'silva, Clive Davis, Mary Wilson, Karen Robinson, Brian Perry, Amanda Urseil, Andrew Grice Political Editor, Martin James, Simon Wilde, Robert Sandall, Eleanor Mills, Anthony Sattin, Robert Winnett, Irwin Stelzer, Rev C L Rawlins, Robert Hewison, George Turnbull, David Dougill, Philippe Boucheron, Hamish Scott, Mark Lanegan, John Evans, Philip Kingsley, Thrasy Petropoulos, David Hewson, Michael Howlett Director, Major Don, Jenny Cope, Harvey Porlock, Tania Alexander, Margaret Coles, Hugh Canning, Alasdair Reid, Jeremy Clarkson, Wade Toomey, David Nokes, Edward Porter, David Cairns, Louise Taylor, John Waples Deputy City Editor, Stewart Lee, Jenny Shields, Anthee Carassava, Paul Eddy, John Wapies Deputy City Editor, Alan Millard, George Perry, Robin Marlar, Graham Otway, Shelley von Strunckel, Joe Perry, Paul Ham, Stuart Wavell, Maggie Gee, Paul Donovan, Denis Rigden, Jonathan Leake Transport Correspondent, Dr William Pyle, Sue Lawrence, R J, Smita Talati, Paul Driver, Derek Clements, Boris Schapiro, Garth Pearce, Ann McFerran, Sue Fox, Maeve Sheehan, Nicholas Hellen, Ian Hawkey, Ian Chadband, Harald Doornbos, Monica Bridge, Alicia Wyllie, Mark Edwards, Kirstie Hamilton, Tom Shone, Susan Clark, Stephen Amidon, Mark Austin, David Lawrenson, Zoe Brennan Westminster Correspondent, Phil Baker, John Harlow Arts Correspondent, Rosemary Spence, Simon Wilde cricket correspondent, Lois Rogers, Raymond Keene, Jonathan Leake Environment Correspondent, John Karter, Cosmo Landesman, Lisa Brinkworth, Andrew Roberts, Allegra Donn, Diana Wright, Debbie Hill, Helen Hawkins, Chris Partridge, Rebecca Tanqueray, Richard Evans, Nick Cain, Hal Prince, Andrew Smith, Jeremy Scott, Tim Moorey, Andrew Grice, Martin Searby, Claire Oldfield, Marc Almond, David Walsh, Simon Murray, Miranda Kaufmann, Mark MacAskill, John Stern, Trevor Lewis, Rasselas, Bryan Appleyard, Lois Rogers Medical Correspondent, Maureen Robinson, Lisa Sykes, Seamus Heaney, Michael Bradley, Christopher Goodwin, Paul Kavanagh, Josh Salzmann, Sheryl Garratt, Garth Alexander, William Rees-Mogg, Maurice Chittenden, Ray Hutton, John Wilcockson, Paul Walter, Jon Ungoed-Thomas, Peter Watts, Susan Elkin, Jonathan Leake, Tara Palmer-Tomkinson, Michael Sheridan, Frank Willats, Christine Webb, Fay Weldon, TakSang Li, Matthew Lynn, Godfrey Smith, Michael Austin, Michael Hodges, Mandy Payne, Andrew Alderson, John Waples, Terry Murden, A A Gill, Matthew Campbell, Richard Stevens, Michael Cocks, David Campbell, John Carey, Kirsty Lang, David Sumner Smith, Mark Colegate, Jayne Zito, Robert Johnston, Stephen Pettitt, Trushar Barot, Cherry Norton, Kevin Goldstein-Jackson, John Spurling, Andrew Lorenz, Hugo Vickers, Naomi Caine, David Wickers, Jane Hardy, Roger Dobson, Donald Watts, Jeremy Lazell, Mark Hodson, Andrew Frankel, Nicholas Hellen Media Correspondent, Tim Llewellyn Director The Henry Moore Foundation, Rupert Steiner, James Henderson, Annalisa Miller, Hugh Pearman, John Phillips, Penny Perrick, Tom Deveson, Derek Draper, Simon Trump, Zoe Linkson, Carey Scott, David Long, Eve Arenstraum, Stephen Boyd, Joanna Simon, Chris Evans, Kingston Smith, Simon Howard, Dan Pearson, Dominic Rushe, Georgina Howell, Adam Parsons,
... new star Planet Hollywood faces judgment day Founder Robert Earl's star is waning as Wall Street ... launch a clothing range and now, she tells Robert Johnston, she's also writing a book Men ...
1998 - Gale Group | Sunday Times HA GDA
Emiliano Calvo, María Alsina, Jan H.M. Schellens, Alwin D. R. Huitema, Josep Tabernero, Aurelia de Vries-Schultink, Valentina Boni, Bernard Doger, Cecile Geuijen, Robert P. Doornbos, Kees Bol, Martine Westendorp, Mark Throsby, Lex Bakker, Setareh Shamsili,
... Vries-Schultink, Valentina Boni, Bernard Doger, Cecile Geuijen, Robert Doornbos, Kees Bol, Martine Westendorp, Mark Throsby, Lex Bakker, ...
Tópico(s): Glycosylation and Glycoproteins Research
2016 - American Association for Cancer Research | Cancer Research
Waldemar Januszczak, John Dugdale, Michael Prescott, Richard Jeffrey, Mark Stretton, Barney Spender, Barbara Hall, Alec Stewart, San Francisco Symphony, Christopher Morgan Religious Affairs Correspondent, Jeff Dawson, N J, Jon Swain, James Clark, Nicholas Rufford, George Flyde, Rob Hughes, John Peter, John Mooney, Jonathan Miller, John Jay, J D, Adam Luck, Jon Pratty, Emine Saner, Cherie Blair, Frank Whitford, Anderson Investigates, Gordon Stewart, Paul Sanders, Keith Potts, Sam Gilpin, Sally Payne, Melanie Rickey, David Smith, Tim Richards, Melanie Phillips, Neil Wormald, E P, Clive Davis, Joe Lauria, Vincent Kearney, Mary Wilson, K R, Dr Roger Henderson, Tony Allen-Mills, Simon Wilde, Nixon Carter, Martin James, Tom Walker, David Greene Circulation Director, Malcolm Brook, Robert Winnett, Irwin Stelzer, Robert Hewison, Peter Wilson, John Dickinson, Adam Tanswell, Professor Nick Bosanquet, John Gribbin, John Evans, Philip Kingsley, Thrasy Petropoulos, Steve Curry, David Reekie, Sarah Toyne, David Hewson, Jo Glanville Blackburn, Tania Alexander, Margaret Coles, Hugh Canning, Margarette Driscoll, Alasdair Reid, Chris Dedicoat, John Sutherland, Jeremy Clarkson, Stewart Lee, Edward Porter, Peter Conradi, Louise Taylor, S L, Max Anderson, Felicity Wilcox, Eben Black, David Crane, Professor Tim Congdon, P Hancox, John Fawcett, Nick Caln, John Hart, Liz Jones, Kevin Rafter, Alex Kershaw, Andy Bannister, Nick Gardner, Timothy St Ather, B Porter, Michael Tilson Thomas, Phillip Oppenheim, Paul Ham, Rick Francis, Paul Donovan, Deborah Collcutt, Alastair Hendy, Digby Hildreth, Tim Salmon, Simon Mills, Hugh McIlvanney, Susan Clark Health Journalist, Andrew Barratt, Lucinda Kemeny, Jasper Gerard, Paul Driver, John Humphrys, Nick Newman, Peter Windsor, Sue Fox, Nigel Burnham, Ann McFerran, Ian Hawkey, Shelley Von Strunckel, Alex Clark, Madonna, Christopher Morgan, Harald Doornbos, Walter Grey, Mark Edwards, Susan Clark, Colin Angwin, David Lawrenson, Eben Black Chief Political Correspondent, Danny O'Brien, Phil Baker, Lois Rogers, Simon Veness, Raymond Keene, Peter Martin, Gerry Berger, Senay Boztas, Cosmo Landesman, Lisa Brinkworth, Marie Colvin, Diana Wright, Marion Phillips, William Peakin, Andy Knott, Los Angeles, Chris Partridge, Michael Prescott Political Editor, Stephen Jones, Stephen Bleach, Richard Evans, Uzi Mahnaimi, Natalie Graham, Lois Rogers Medical correspondent, Dominic Rushe, Professor Douglas McWilliams, Keith Wheatley, Pat Butcher, Claire Oldfield, David Walsh, Sir Howard Davies, Mark MacAskill, Wendy Bristow, Trevor Lewis, Jack Grimston, S P, Colin McDowell, Ben Pimlott, Stephen Armstrong, Nick MacKinnon, Professor David Gowland, Christopher Goodwin, Paul Kavanagh, Bethan Cole, Mark Prigg, Victoria O'brien, Clover Dahl, Maurice Chittenden, Alex Fortune, Kevin Pratt, Nick Hanna, Alasdair Reid golf correspondent, Dr Patrick Moore, Andrew Lorenz Business Editor, Richard Rae, Mark Franchetti, John Wilcockson, Ray Hutton, Jon Ungoed-Thomas, Arthur J Hayward-Costa, Gus MacDonald, D J Taylor, Anthony Johnson, Charles Pelkey, Christopher Tennant, Michael Brady, John Harlow, Godfrey Smith, John Urbanek, Dipesh Gadher, Richard George, Hunter Davies, Ann Natanson, A A Gill, Matthew Campbell, John Carey, Joel Lardner, Philip Webster, Nadine Meisner, David Sumner Smith, Dr Walter Eltis, Nick Fielding, Stephen Pettitt, Jonathan Leake Science Editor, David Clark, Rw Johnson, Geoffroy Tailleur, Andrew Lorenz, Sally Kinnes, Steven Weaver, Nicholas Hellen Media Editor, Tim Little-wood, Liam Clarke, Roger Dobson, Frank Prochaska, David Wickers, Sirl Dal, John Cornwell, Adam Manktelow, Mark Hodson, Andrew Frankel, Graham Norwood, Christine Lees, Rupert Steiner, Hugh Pearman, R Sylvester, Dan Cairns, Christopher Bray, David Parsley, Bill Cotton, David Smith Economics Editor, Arthur Welss, Tom Deveson, Simon Crerar, Peter Roebuck, Professor Anthony Clare, Walter Ellis, Joanna Simon, India Knight, Steve Grant, Simon Howard, Danny Danziger, Dan Pearson, A Fraser, Rosie Waterhouse, Kate Constable, Boris Schapiro,
... survival by offering the top mortgage deals, writes Robert Winnett Liverpool Victoria Skipton members in line for £ ... teachers are paid more per hour than accountants. Robert Winnett reveals how the pay of different professions ...
2000 - Gale Group | Sunday Times HA GDA
Anne Brandts, Stijntje D. Roes, Joost Doornbos, Robert G. Weiss, Albert de Roos, Matthias Stuber, Jos J.M. Westenberg,
Abstract Purpose: To evaluate accuracy and reproducibility of flow velocity and volume measurements in a phantom and in human coronary arteries using breathhold velocity‐encoded (VE) MRI with spiral k ‐space sampling at 3 Tesla. Materials and Methods: Flow velocity assessment was performed using VE MRI with spiral k ‐space sampling. Accuracy of VE MRI was tested in vitro at five constant flow rates. Reproducibility was investigated in 19 healthy subjects (mean age 25.4 ± 1.2 years, 11 men) by repeated ...
Tópico(s): Cardiovascular Function and Risk Factors
2010 - Wiley | Journal of Magnetic Resonance Imaging
Waldemar Januszczak, John Dugdale, Alicia Wyille, B A, Barney Spender, Tony Keegan, Barbara Hall, Judith O'Reilly Education Correspondent, Donald MacGillivray, Andrew Warshaw, Allyson Solf, Alex McGregor, Jon Swain, Anthony Clare, Lewis Reed, John Peter, Pam Barrett, Amanda Ursell, Nick Bradshaw, Lesley White, John Jay, Emily Hourihan, Max Glaskin, Susan d'Arcy, Anders Moberg, Ivo Tennant, Sharon Smith, Ferdinand Mount, Sam Gilpin, Addison de Witt, Sally O'Reilly, Lucy Hughes-Hallett, David Smith, Kirstie Hamilton City Editor, Tim Richards, Humphrey Carpenter, Chris Dignan, Nick Pitt, Neil Wormald, Cameron Docherty, Andrew Sullivan, Clive Davis, E S Hotston, Leo Katzen, Mary Wilson, Karen Robinson, Josh Saizmann, Lewis Lesley Professor, Dylan Jones, Chris Goodwin, Andrew Grice Political Editor, Oscar Peterson, Edward Platt, John Lawless, Tony Allen-Mills, Martin James, Robert Sandall, Eleanor Mills, Anthony Sattin, Steve Farrar, Susan d'ARCY, Alison Brace, Margaret P Patterson, Irwin Stelzer, Sarah Higgins, Peter Wilson, Ron Chernow, Roger Anderson, Charlotte Wolff, Robert Hewison, David Dougill, John Evans, Philip Kingsley, Thrasy Petropoulos, Chris Smith Mp, Marian Martin, David Hewson, Harvey Porlock, Yvonne Ridley, Margaret Coles, Hugh Mcllvanney, Hugh Canning, Jeremy Clarkson, Stewart Lee, Edward Porter, Alan Brownjohn, Hala Halim, Michael Jones, George Perry, Graham Otway, Robin Marlar, Charles Hughes, Nick Gardner, Shelley von Strunckel, Paul Nuki Consumer Affairs Correspondent, Terry Solomon, Stuart Wavell, Guy Richards, Paul Donovan, Jonathan Leake Transport Correspondent, Piers Paul Read, Sue Lawrence, N C A, Jean Loutz, Paul Driver, Ian Hawkey, Ian Chadband, Alex Ferguson, Christopher Morgan, Harald Doornbos, Michael Jenner, Alicia Wyllie, Michael Prescott Chief Political Correspondent, Kirstie Hamilton, Tom Shone, Mark Edwards, Susan Clark, Mark Austin, David Lawrenson, Nicholas Rufford Home Affairs Editor, Nick Montagu Chairman, Andy Goldberg, Phil Baker, John Harlow Arts Correspondent, Lois Rogers, Raymond Keene, John Karter, A I G, Robert Nutter, Cosmo Landesman, Marie Colvin, Lewis Rèed, Debbie Hill, Diana Wright, Simon Willis, Allegra Donn, Stephen Jones, Councillor Sir Jeremy Beecham Chairman, Richard Evans, Nick Cain, Michael Cooper Director General, Peta Bee, Michael Wright, Natalie Graham, David Pleat, Andrew Grice, Rob Ryan, Keith Wheatley, Claire Oldfield, Miranda Seymour, John Stern, Trevor Lewis, Rasselas, Professor Peter Mortimore, Bryan Appleyard, Christopher Goodwin, Paul Kavanagh, Sheryl Garratt, Diana, Paul Burwell, J McBrien, Garth Alexander, Rachel Cooke, Christine Tozer, Maurice Chittenden, Andrew Lorenz Business Editor, Mark Franchetti, Ray Hutton, Julie Burchill, Jon Ungoed-Thomas, Brian Moore, Klair Norton, Peter Watts, Kevin McCarra, Ricky Dalton, Susan Elkin, Tara Palmer-Tomkinson, S J, Peter Stanford, Michael Sheridan, John Harlow, Matthew Lynn, Godfrey Smith, Michael Austin, Andrew Alderson, A A Gill, Aoife O'brien, P E Varea, Matthew Campbell, Philip Mansergh, John Carey, David Hutcheon, Kirsty Lang, George Drower, Robert Johnston, Stephen Pettitt, Cherry Norton, Eddie Barlow, Andrew Lorenz, Lembit Öpik Mp, Naomi Caine, Mark Sanderson, David Wickers, Cherie Booth, Roger Dobson, Mark Hodson, Andrew Frankel, Nicholas Hellen Media Correspondent, Richard Webster, Rupert Steiner, Ali Stewart, Lucy Broadbent, Hugh Pearman, Dan Cairns, Connie Tindale, David Parsley, John Burns, David Smith Economics Editor, Mary Greenwell, W G H, Bob Dwyer, Diana Taylor, Stephen Boyd, Joanna Simon, Philip Jacobson, Dan Pearson, Lisa Verrico, Dominic Rushe, Nigel Nicolson, Boris Schapiro, Adam Parsons, Tania Hunter,
Earth moves for women as scientists find love pill Asylum tide costs Britain £2bn a year Sheepish Sheringham cleared for the Cup Contents Virgin Contents ...
1998 - Gale Group | Sunday Times HA GDA
Cecile Geuijen, Eric Rovers, Tristan Gallenne, David Maussang-Detaille, Arjen Kramer, Nellie Nieuwenhuizen, Carina Clements, Katinka van Zoest, Roy Nijhuis, Therèse Visser, Renate den Blanken-Smit, Willem Bartelink, Vanessa Zondag-van der Zande, Linda Kaldenberg, Pieter-Fokko van Loo, Rob C. Roovers, Robert P. Doornbos, Leo Price, Stefan Braam, Setareh van Driel, Lex Bakker, Ton Logtenberg, John de Kruif, Mark Throsby,
... Linda Kaldenberg, Pieter-Fokko van Loo, Rob Roovers, Robert Doornbos, Leo Price, Stefan Braam, Setareh van Driel, Lex ...
Tópico(s): Radiopharmaceutical Chemistry and Applications
2015 - American Association for Cancer Research | Cancer Research
Evelien Snippe, Bennard Doornbos, Robert A. Schoevers, Klaas J. Wardenaar, Marieke Wichers,
Research so far provided few clues on the order in which depressive symptoms typically remit during treatment. This study examined which depressive symptoms improve first, and whether symptoms changed before, simultaneous with, or after the core symptoms of depression (i.e., sad mood, loss of pleasure, and loss of interest). Participants were 176 patients with Major Depressive Disorder (MDD) receiving outpatient treatment (a combination of pharmacotherapy and psychological interventions) for depression. ...
Tópico(s): Anxiety, Depression, Psychometrics, Treatment, Cognitive Processes
2021 - Elsevier BV | Journal of Affective Disorders
Aurelia H. M. de Vries Schultink, Kees Bol, Robert P. Doornbos, Anastasia Murat, Ernesto Wasserman, Thomas P. C. Dorlo, Jan H.M. Schellens, Jos H. Beijnen, Alwin D. R. Huitema,
Tópico(s): Protein purification and stability
2020 - Adis, Springer Healthcare | Clinical Pharmacokinetics
Pieter Fokko van Loo, Basav N. Hangalapura, Soley Thordardottir, John D. Gibbins, Henrike Veninga, Linda Hendriks, Arjen Kramer, Rob C. Roovers, Marij Leenders, John de Kruif, Robert P. Doornbos, Andres Sirulnik, Mark Throsby, Ton Logtenberg, Harry Dolstra, Alexander B. H. Bakker,
Objective: We report the characterization of MCLA-117, a novel T cell-redirecting antibody for acute myeloid leukaemia (AML) treatment targeting CD3 on T cells and CLEC12A on leukaemic cells. In AML, CLEC12A is expressed on blasts and leukaemic stem cells.Methods: The functional capacity of MCLA-117 to redirect resting T cells to eradicate CLEC12APOS tumor cells was studied using human samples, including primary AML samples.Results: Within the normal hematopoietic compartment, MCLA-117 binds to cells ...
Tópico(s): Immunotherapy and Immune Responses
2019 - Taylor & Francis | Expert Opinion on Biological Therapy
Aurelia H. M. de Vries Schultink, Robert P. Doornbos, Alexander B. H. Bakker, Kees Bol, Mark Throsby, Cecile Geuijen, David Maussang, Jan H.M. Schellens, Jos H. Beijnen, Alwin D. R. Huitema,
Summary Introduction MCLA-128 is a bispecific monoclonal antibody targeting the HER2 and HER3 receptors. Pharmacokinetics (PK) and pharmacodynamics (PD) of MCLA-128 have been evaluated in preclinical studies in cynomolgus monkeys and mice. The aim of this study was to characterize the PK and PD of MCLA-128 and to predict a safe starting dose and efficacious clinical dose for the First-In-Human study. Methods A PK-PD model was developed based on PK data from cynomolgus monkeys and tumor growth data ...
Tópico(s): Advanced Biosensing Techniques and Applications
2018 - Springer Science+Business Media | Investigational New Drugs
Tiziana Adage, Francesca Del Bene, Francesco Fiorentini, Robert P. Doornbos, Christina Zankl, Michael R. Bartley, Andreas J. Kungl,
Neutrophils play a fundamental role in a number of chronic lung diseases. Among the mediators of their recruitment to the lung, CXCL8 (IL-8) is considered to be one of the major players. CXCL8 exerts its chemotactic activity by binding to its GPCR receptors (CXCR1/R2) located on neutrophils, as well as through interactions with glycosaminoglycans (GAGs) on cell surfaces including those of the microvascular endothelium. Binding to GAG co-receptors is required to generate a solid-phase haptotactic gradient ...
Tópico(s): Chronic Obstructive Pulmonary Disease (COPD) Research
2015 - Elsevier BV | Cytokine
Pieter Fokko van Loo, Robert P. Doornbos, Harry Dolstra, Setareh Shamsili, Lex Bakker,
Abstract Although chemotherapy regimens induce initial remissions in most acute myeloid leukemia (AML) patients, their long term prognosis is very poor. Novel targeted therapies that effectively eradicate both AML blasts and their progenitors are needed.MCLA-117, a potent human CLEC12AxCD3 bispecific IgG antibody redirects patient's cytotoxic T cells to induce AML tumor lysis. CLEC12A is a myeloid differentiation antigen that is expressed on 90-95% of newly diagnosed and relapsed AML. Moreover, CLEC12A ...
Tópico(s): Acute Myeloid Leukemia Research
2015 - Elsevier BV | Blood
Geertje J. D. van Mierlo, Nicole H.P. Cnubben, C. Frieke Kuper, Jasja Wolthoorn, Angelique P. van Meeteren-Kreikamp, Machiel M. Nagtegaal, Robert P. Doornbos, Niels‐Christian Ganderup, André Penninks,
The use of recombinant human proteins for the treatment of several diseases has increased considerably during the last decades. A major safety and efficacy issue of biopharmaceuticals is their potential immunogenicity. To prevent immunogenicity, biotechnology-derived proteins are engineered to be as human-like as possible. Immunogenicity is mainly determined in non-human primates (NHP), as they are considered to be the best predictive animal species for human safety, based on their close relatedness ...
Tópico(s): Virus-based gene therapy research
2012 - Informa | Journal of Immunotoxicology
Marleen H.M.C. van Nuenen, Rianne A.F. Ligt, Robert P. Doornbos, Janneke C.J. Woude, Ernst J. Kuipers, Koen Venema,
Microbial metabolites may influence the metabolic integrity of intestinal epithelial cells and induce mucosal immune responses. Therefore, we investigated the effects of the microbial metabolites butyrate, iso-valerate, and ammonium on Caco-2 cells and macrophages. Barrier functioning was determined by measuring transepithelial electrical resistance and basolateral recoveries of metabolites. The barrier function of Caco-2 cells remained intact after exposures. Basolateral recoveries ranged from ...
Tópico(s): Barrier Structure and Function Studies
2005 - Oxford University Press | FEMS Immunology & Medical Microbiology
Kitty Verhoeckx, Robert P. Doornbos, Renger F. Witkamp, J. van der Greef, Richard J. Rodenburg,
Vascular endothelial growth factor (VEGF), oncostatin M (OSM), and granulocyte chemotactic protein-2 (GCP-2/CXCL6) are up-regulated in U937 macrophages and peripheral blood macrophages exposed to LPS, beta-adrenergic receptor (beta2-AR) agonists (e.g. zilpaterol, and clenbuterol) and some other agents that induce intracellular cAMP (prostaglandin E2, forskolin, and butyryl cAMP). LPS in combination with beta2-agonists and cAMP elevating agents had an additional effect on the release of VEGF, OSM, and ...
Tópico(s): Cancer, Stress, Anesthesia, and Immune Response
2005 - Elsevier BV | International Immunopharmacology
Kitty Verhoeckx, Marco Gaspari, Sabina Bijlsma, J. van der Greef, Renger F. Witkamp, Robert P. Doornbos, Richard J. Rodenburg,
Two-dimensional difference gel electrophoresis (DIGE) in combination with univariate (Student's t-test) and multivariate data analysis, principal component analysis (PCA) and partial least squares discriminant analysis (PLS-DA) were used to study the anti-inflammatory effects of the beta(2)-adrenergic receptor (beta(2)-AR) agonist zilpaterol. U937 macrophages were exposed to the endotoxin lipopolysaccharide (LPS) to induce an inflammatory reaction, which was inhibited by the addition of zilpaterol (LZ). ...
Tópico(s): Cholesterol and Lipid Metabolism
2005 - American Chemical Society | Journal of Proteome Research
Kitty Verhoeckx, Robert P. Doornbos, J. van der Greef, Renger F. Witkamp, Richard J. Rodenburg,
In this study the anti-inflammatory properties of zilpaterol, a beta2-adrenergic receptor (AR) agonist specifically developed as a growth promoter in cattle were investigated. Although zilpaterol has a different structure compared with the beta2-AR agonists known to date, it was noted that it was able to bind to both the beta2-AR (Ki = 1.1 x 10(-6)) and the beta1-AR (Ki = 1.0 x 10(-5)). Using lipopolysaccharide (LPS)-exposed U937 macrophages, the production of cyclic adenosine-3',5'-cyclic monophosphate ( ...
Tópico(s): Neuropeptides and Animal Physiology
2005 - Wiley | Journal of Veterinary Pharmacology and Therapeutics
Marcel V. W. Wijnands, Marjan J. van Erk, Robert P. Doornbos, Cyrille Krul, R.A. Woutersen,
The effects of different dietary compounds on the formation of aberrant crypt foci (ACF) and colorectal tumours and on the expression of a selection of genes were studied in rats. Azoxymethane-treated male F344 rats were fed either a control diet or a diet containing 10% wheat bran (WB), 0.2% curcumin (CUR), 4% rutin (RUT) or 0.04% benzyl isothiocyanate (BIT) for 8 months. ACF were counted after 7, 15 and 26 weeks. Tumours were scored after 26 weeks and 8 months. We found that the WB and CUR diets inhibited ...
Tópico(s): Curcumin's Biomedical Applications
2004 - Elsevier BV | Food and Chemical Toxicology
Robert P. Doornbos, Marga Theelen, P.C.J. van der Hoeven, Wim J. van Blitterswijk, Arie J. Verkleij, Paul M.P. van Bergen en Henegouwen,
Protein kinase B (PKB), also known as Akt or RAC-PK, is a serine/threonine kinase that can be activated by growth factors via phosphatidylinositol 3-kinase. In this article we show that PKCζ but not PKCα and PKCδ can co-immunoprecipitate PKB from CHO cell lysates. Association of PKB with PKCζ was also found in COS-1 cells transiently expressing PKB and PKCζ, and moreover we found that this association is mediated by the AH domain of PKB. Stimulation of COS-1 cells with platelet-derived growth factor ( ...
Tópico(s): Coagulation, Bradykinin, Polyphosphates, and Angioedema
1999 - Elsevier BV | Journal of Biological Chemistry
Roger A.H. Adan, M. van der Kraan, Robert P. Doornbos, P.R. Bär, J.P.H. Burbach, Willem Hendrik Gispen,
Tópico(s): Biochemical Analysis and Sensing Techniques
1996 - Elsevier BV | Molecular Brain Research
Elbert A.J. Joosten, Sandra Verhaagh, Didier Martin, Pierre A. Robe, Rachelle Franzen, Michel J. J. Hooiveld, Robert P. Doornbos, P.R. Bär, Gustave Moonen,
Peptides related to melanocortin (a MSH) and corticotropin (ACTH), collectively termed melanocortins, exert trophic effects on the outgrowth of neurites from peripheral and central nervous system in vitro. Here we study the neurite outgrowth promoting effect of α-MSH on corticospinal (CS) neurons in vitro. Corticospinal neurons were identified in cell culture of neonatal rat cortex by immunostaining of cholera toxin subunit B (CTB), retrogradely transported from the cervical parts of the spinal cord. ...
Tópico(s): Neuropeptides and Animal Physiology
1996 - Elsevier BV | Brain Research
Rob C. Roovers, Bram Herpers, Mark I. James, Berina Eppink, Carme Cortina, David Maussang-Detaille, Ingrid Kolfschoten, Sylvia Boy, Marc van de Wetering, Wim de Lau, Robert P. Doornbos, Kuan Yan, Lucia Salinaro, Lex Bakker, John de Kruif, Hans Clevers, Robert G.J. Vries, Eduard Batlle, Leo Price, Mark Throsby,
... Boy, Marc van de Wetering, Wim De Lau, Robert Doornbos, Kuan Yan, Lucia Salinaro, Lex Bakker, john de Kruif, Hans Clevers, Robert Vries, Eduard Batlle, Leo Price, Mark Throsby. Preclinical ...
Tópico(s): Colorectal Cancer Treatments and Studies
2017 - American Association for Cancer Research | Cancer Research
Mirjam Simoons, Hans Mulder, Bennard Doornbos, Robert A. Schoevers, Eric N. van Roon, Henricus G. Ruhé,
Introduction Somatic complications account for the majority of the 13–30 years shortened life expectancy in psychiatric patients compared to the general population. The study aim was to assess to which extent patients visiting outpatient departments for mood and anxiety disorders were monitored for relevant somatic comorbidities and (adverse) effects of psychotropic drugs–more specifically a) metabolic parameters, b) lithium safety and c) ECGs—during their treatment. Methods We performed a retrospective ...
Tópico(s): Treatment of Major Depression
2018 - Public Library of Science | PLoS ONE
J. L. Bloem, T H Falke, A. H. M. Taminiau, J Doornbos, A.T. van Oosterom, Robert M. Steiner, E E Overbosch, B. G. Ziedses des Plantes,
HomeRadioGraphicsVol. 5, No. 6 PreviousNext Free AccessMagnetic resonance imaging of primary malignant bone tumors.J L Bloem, T H Falke, A H Taminiau, J Doornbos, A T Van Oosterom, R M Steiner, E E Overbosch, B G Ziedses des Plantes, JrJ L Bloem, T H Falke, A H Taminiau, J Doornbos, A T Van Oosterom, R M Steiner, E E Overbosch, B G Ziedses des Plantes, JrJ L BloemT H FalkeA H TaminiauJ DoornbosA T Van OosteromR M SteinerE E OverboschB G Ziedses des Plantes, JrPublished Online:Nov 1 1985https://doi. ...
Tópico(s): Bone Tumor Diagnosis and Treatments
1985 - Radiological Society of North America | Radiographics
Anne‐Marie Zuurmond, Angela Koudijs, B. van El, Robert P. Doornbos, Babs C.T. van Manen-Vernooij, Jacqueline H.M.W. Bastiaans, André Penninks, Jolanda van Bilsen, Nicole H.P. Cnubben, Jeroen DeGroot,
Pharmacokinetic properties and safety profile of a drug are likely influenced by the disease state of a patient. In this study, we investigated the influence of arthritic processes on pharmacokinetics and immunotoxicity of interleukin-1 receptor antagonist (Anakinra) in the rat adjuvant arthritis model. Anakinra dose-dependently suppressed joint inflammation and degradation as demonstrated by reduced clinical arthritis score, paw thickness, synovial infiltration and bone degradation. In addition, ...
Tópico(s): Immunotoxicology and immune responses
2011 - Elsevier BV | Regulatory Toxicology and Pharmacology
Joke Löwenberg-Doornbos, Robert Freedman,
... People With Mental Illness and Their TreatmentJoke Löwenberg-Doornbos M.D.Robert Freedman M.D.Joke Löwenberg-Doornbos M.D.Robert Freedman M.D.Published Online:1 Jun 2008https:// ...
Tópico(s): Mental Health and Psychiatry
2008 - American Psychiatric Association | American Journal of Psychiatry
Edy Soffer, Frank A. Mitros, Joost Doornbos, Jay L. Friedland, Janice L. Launspach, Robert W. Summers,
Tópico(s): Effects of Radiation Exposure
1994 - Springer Science+Business Media | Digestive Diseases and Sciences
Jos J.M. Westenberg, Rob J. van der Geest, Hildo J. Lamb, Michel I.M. Versteegh, Jerry Braun, Joost Doornbos, Albert de Roos, Ernst E. van der Wall, Robert Dion, Johan H. C. Reiber, Jeroen J. Bax,
Background— Data on reverse remodeling of the left atrium (LA) and left ventricle (LV) after restrictive annuloplasty in patients with dilated cardiomyopathy are scarce, and follow-up studies are performed with echocardiography. Methods and Results— Twenty patients with dilated cardiomyopathy and severe mitral regurgitation selected for restrictive mitral annuloplasty underwent serial MRI studies (within 1 week before surgery, and 2 months [n =18] and 1 year [n =13] after surgery). Early mortality was ...
Tópico(s): Cardiac Imaging and Diagnostics
2005 - Lippincott Williams & Wilkins | Circulation