Limpar
121 resultados

Acesso aberto

Tipo do recurso

Ano de criação

Produção nacional

Revisado por pares

Áreas

Idioma

Editores

Jornais Acesso aberto

Jeremy Rundall, Calman, Vincent Hanta, Alex Finer, Terry Delaney, James Margach, John Keats, Oliver Stanley, AFGL, Philip Norman, Harold Hobson, Athole Still, Rob Hughes, Kenneth Pearson, Graham Rose, James Poole, Antony Terry, Colin Tilney, John Whale, Alfred O'Shaugnessy, Jason Tomas, A J Howarth, Richard Streeton, Philip Oakes, Henry Brandon, Thomas Balogh, Nicholas Taylor, John Russell, Richard Milner, Gerard Mansell, Deryk Brown, Cliff Temple, Charles G Miller, Philip Clarke, Derek Jewell, A R Watson, Vivian Jenkins, Murray Sayle, Wendy Hughes, Tom Margerison, Gillian Widdicombe, Ruth Hall, John Taylor, George Perry, John Milton, Robin Marlar, Robert Troop, Thomas Hickman, H. F. Lovelock, Shirley Conran, Peter Lennon, Cecil Beaton, Raymond Mortimer, Maxwell Boyd, Tony Geraghty, Brian Jackman, Henry Reuter, Edward Fitzgerald, W F Gross, John Hopkins, Denis Herbstein, Eric Marsden, Peter Wilsher, Peter Cranmer, Aziz Khan-Panni, Irwin N Bellow, Bryan Silcock, Patricia Connor, Eric Jacobs, Roger Mortimer, James Wilson, Arnold Legh, Ernestine Carter, Michael Pye, Desmond Shawe-Taylor, Lyman Andrews, Dylon Thomas, Alan Brien, Michael Bateman, Stephen Aris, Bennie Gray, Patrick Rowley, Lanning Roper, Jean Robertson, Ronald Butt, Dilys Powell, Reginald Sailberg, Oliver Gillie, Elkan Allan, Andrew Marvell, Hugo Young, Felix Aprahamian, H J Deverson, Jack Fingleton, Maurice Cranston, J W Lambert, C. H. O'd Alexander, Henry Longhurst, Michael Manning Athens, James Margach Political Correspondent, Christopher Ricks, Edna St Vincent Millay, Naomi Mitchison, Tony Dawe, Brian Glanville, David Williams, Keith Richardson, J W Rouse, Graham Searjeant, Peter Dunn, Michael Green, William Shakespeare, Maurice Wiggin, Arthur Jacobs, Nicholas Faith, Barbara Cartland, J K Gordon, Allan Hall, Philip Radcliffe, Aziz Khan-Pannl, Harlow Unger, Brenda Jones, John Hallows, Vincent Hanna, T S Eliot, Hugh Trevor-Roper, Boris Schapiro, Hugh Trevlor-Roper, Nicholas Tomalin,

... from Hume to the Vienna Circle by Leszek Kolakowski/Penguin 40p Weidenfeld Nicolson Calder & Boyars Robert Hale Paperback Short List The Arts endpiece A ...

1972 - Gale Group | Sunday Times HA GDA

Artigo Revisado por pares

James F. Blake, John J. Gaudino, Jason De Meese, Peter Mohr, Mark J. Chicarelli, Hongqi Tian, Rustam Garrey, Allen A. Thomas, Christopher S. Siedem, Michael B. Welch, Gabrielle R. Kolakowski, Robert Kaus, Michael Burkard, Matthew Martinson, Huifen Chen, Brian Dean, Danette A. Dudley, Stephen E. Gould, Patrícia Pacheco, Sheerin Shahidi-Latham, Weiru Wang, Kristina West, Jianping Yin, John G. Moffat, Jacob B. Schwarz,

The discovery and optimization of a series of tetrahydropyridopyrimidine based extracellular signal-regulated kinase (Erks) inhibitors discovered via HTS and structure based drug design is reported. The compounds demonstrate potent and selective inhibition of Erk2 and knockdown of phospho-RSK levels in HepG2 cells and tumor xenografts.

Tópico(s): Protein Kinase Regulation and GTPase Signaling

2014 - Elsevier BV | Bioorganic & Medicinal Chemistry Letters

Artigo Acesso aberto Revisado por pares

Janusz Kołakowski, Robert Makuch, Dariusz Stępkowski, Renata Da̧browska,

Titration of F-actin with calponin causes the formation of two types of complexes. One, at saturation, contains a lower ratio of calponin to actin (0.5:1) and is insoluble at physiological ionic strength. The another is soluble, with a higher ratio of calponin to actin (1:1). Electron microscopy revealed that the former complex consists of paracrystalline bundles of actin filaments, whereas the latter consists of separate filaments. Ca(2+)-calmodulin causes dissociation of bundles with simultaneous ...

Tópico(s): Cardiomyopathy and Myosin Studies

1995 - Portland Press | Biochemical Journal

Artigo Revisado por pares

Donald Kolakowski, Robert M. Malina,

Tópico(s): Spatial Cognition and Navigation

1974 - Nature Portfolio | Nature

Jornais Acesso aberto

By Peter Evans Home Affairs Correspondent, By a Staff Reporter, From Dan van der Vat, By A. M. Rendel, Diplomatic Correspondent, A Staff Reporter, By Nature-Times News Service, From Ian Mcdonald, By George Clark, Political Staff, From Our Correspondent, By Alan Hamilton Labour Staff, By Our Political Staff, Our Bournemouth Correspondent, Our Aylesbury Correspondent, By Stephen Jessel Education Correspondent, By Paul Routledge Labour Staff, From Roger Berthoud, From Gretel Spitzer, From Peter Nichols, From Our Own Correspondent, From Fred Emery, From Dan Van Der Vat, By Michael Leapman, By A. M. Rendel Diplomatic Correspondent, From David Bonavia, From Moshe Brilliant, From Richard Wigg, From Our Latin America Correspondent, by Kirsten Cubitt, Irving Wardle, Michael Billington, John Higgins, Stanley Reynolds, John Percival, Jeremy Noble, Peter Hazelhurst, Hugh Noyes, Dan van der Vat, PHS, LESZEK KOLAKOWSKI, JULIAN CRITCHLEY, DES WILSON, TIMOTHY RAISON, CHARLES W. GOODWYN, GEORGE POLE, MOLSON, KENNETH MACKENZIE, NICHOLAS L. EDWARDS, JAMES WILSON, STAFFORD BOURNE, ROBERT SHELDON, INAKI BEHOTEGI, SEFTON DELMER, E. J. HOBSBAWM, C. B. S. DOBSON, D. J. STEWART., J. R. RIDGES, GERTRUD JOHNSTON, VERA NELSON, JOHN RIPON, FRED SECOMBE., By Nature-Times News Service., By Geoffrey Green Football Correspondent, By John Hennessy, From John Woodcock Cricket Correspondent, By Joyce Whitehead, By Michael Phillips Racing Correspondent, By Roy McElvie, By Maurice Corina Industrial Editor, By Dennis Dwyer, From Charles Hargrove, By A. Goodrick-Clarke, From Anthony Thomas US Economics Correspondent, BY THE FINANCIAL EDITOR, From John Earle, By Anthony Vice, I. F. PEARCE, D. C. ROWAN, J. WISE, A. R. NOBAY, HUGH JENKINS., M. HILLEL., S. G. LIMB, Mr. R. D. Lord,

News: Hint in Dutschke case of false friend as informer for the police, Hanoi lists prisoners for Mr Kennedy, Hopes fade for early release of kidnap consul, ...

1970 - Gale Group | TDA

Artigo Revisado por pares

Janusz Kołakowski, Robert Makuch, Renata Da̧browska,

Limited proteolysis of actin with trypsin removes its two or three C‐terminal amino acid residues [Proc. Natl. Acad. Sci. USA 81 (1984) 3680–3684]. Carboxypeptidase B‐treatment of G‐ and F‐actin previously digested with trypsin revealed that in the first case preferential release of three and in the second two C‐terminal amino acid residues takes place. Tryptic removal of three but not two C‐terminal amino acid residues of actin causes weakening of its interaction with caldesmon and lowering of the ...

Tópico(s): Cardiomyopathy and Myosin Studies

1992 - Wiley | FEBS Letters

Jornais Acesso aberto

David Duke, Phil Yates, Branimir Anzulovic, John Hambley, Gabriel Josipovici, Helen Johnstone, Len Harris, Robert Cole, Mark Inglefield Political Reporter, Andrew Pierce, Sarah Potter, Roger Hole, Shaun Taylor, Magnus Linklater, George Pendle, Mark Souster, Richard Hobson, Ivo Tennant, Matt Wolf, Philip Howard, Hannah Betts, Hilary Finch, Donald Hutcra, Jason Allardyce and Magnus Linklater, Joanna Bale, Kenneth J. Jordan, Mart Hargle, Jeremy Kingston, Clive Davis, Elizabeth Judge, Oliver Holt Football Correspondent, Carl Mortished, Michael Evans, Defence Editor, Nick Nuttall, Environment Correspondent, Tony Patrick, Tom Walker, Christine Buckley Industrial Correspondent, Geoff Brown, Robert Sheehan, Bridge Correspondent, Roland Watson Political Correspondent, Joe Joseph, David Christie, Wardes, Pat Gibson, Malcolm Bradbury, John O'leary Education Editor, John Bryant, Thrasy Petropoulos, Kevin McCarra and Russell Kempson, Dominic Walsh, Carl Mortished, Charles Bremner and Ben MacIntyre, Matthew Barbour, Raymond Keene Chess Correspondent, Anthony Moorman, Tim Reid, Michael Harvey, Peter Ackroyd, Nick Nuttall Technology Correspondent, Peter Preston, Robin Young, Stephen Farrell, Ian Murray, Medical Correspondent, Edward Garden, Rodney Milnes, D. Cameron Watt Professor, Mike Rosewell Rowing Correspondent, Robert Bruce, Michael Clark, P. B. Harris, John O'Leary, Anatole Kaletsky, Dominick Donald, Anna Blundy, C. C. Storer, Peter Barnard, Leszek Kolakowski, Jasper Gerard, Roger Scruton, Montgomery, Russell Kempson, Paul Armstrong, Michael J. Hendrie Astronomy Correspondent, Carol Midgley Media Correspondent, Philip Webster, Roland Watson, Andrew Pierce and Peter Riddell, Barry Millington, Rob Wright, Geoffrey Dean, Angela Callaghan, John Higgins, Raymond Keene, Russell Wood, Christine Buckley, Matt Dickinson, Frances Gibb, Legal Correspondent, Paul Wilkinson, Kary Mullis, Nigel Cliff, Andrew Drummond, Euan W. MacKie, Arthur Rimbaud, Jonathan Dimbleby, Mick Hume, John Stern, Ian Murray Medical Correspondent, George Walden, J. McCubbin, Richard Duce, Sigrid Aufterbeck, Arthur Leathley and Fraser Nelson, Giles Whittell, Christopher Walker, Carol Midgley and Adrian Lee, Simon De Bruxelles, Mel Webb, Des Dearlove, K. Chapman, Matthew Parris, Kevin McCarra, Chris McGrath, Keith Daniels, Russell Jenkins, Binyamin Netanyahu, Ehud Barak, Yitzhak Mordechai, Benny Begin, Azmi Bishara, Iain Finlayson, Peter Riddell, Ben MacIntyre, Jeremy Hart, Ian Brodie, Alasdair Murray Economics Correspondent, Robert Thomas, Graham Searjeant, Fraser Nelson, R. C. Russell, Mark Henderson, Martin Waller, Chris Ayres, Carl Mortished International Business Editor, Mark Baldwin, Benedict Nightingale, Alexandra Frean, Social Affairs Correspondent, Dr Thomas Stuttaford, Carmen Callil, Amanda McBroom, Russell Celyn Jones, Frances Gibb, Jack Bailey, James Christopher, Alex O'connell, Susan MacDonald, Michael Evans, Alan Lee Racing Correspondent, Robert Rhodes, James Chrisopher, Colni Toibin, Tony Salter, Colin McQuillan, Christopher Irvine,

... deadly myth Dominick Donald Serbia under Milosevic By Robert Thomas c. Hurst & ... Lying and Betrayal By Leszek Kolakowski Penguin, £6.99 ISBN 0 14 028044 8 ...

1999 - Gale Group | TDA

Artigo Acesso aberto Revisado por pares

Lechosław Tomaszewski, Robert Kołakowski,

5G and beyond mobile networks are envisioned as the fundamental components that drive business and societal transformation. The deterioration of the natural environment and climate change have raised questions regarding the role of the mobile network ecosystem and its potential to accelerate innovations in industrial and societal sustainability. This paper describes the challenges facing 5G/6G mobile networks from sectors essential for the sustainable use of natural resources, which include smart ...

Tópico(s): Advanced Wireless Communication Technologies

2023 - Multidisciplinary Digital Publishing Institute | Telecom

Jornais Acesso aberto

Jeremy Rundall, Terry Delaney, Richard Buckle, John Fryer, Philip Norman, Harold Hobson, (Mrs) J B Bright, Peter Gillman, Nina Petrova, Alain Le Garsmeur, Helen Rapp, Denis H R Breatley General Secretary, Graham Rose, James Poole, Antony Terry, Bernard Fergusson, Stanley Reynolds, Diane Fisher, Julian Symons, Jason Tomas, Lucia Van Der Post, Philip Oakes, Nigel Lawson, Henry Brandon, John Russell, Richard Milner, Geoffrey Nicholson, Max Marquis, Helen Gane, Bernard Keeffe Warden, Cliff Temple, Philip Clarke, Derek Jewell, David Tennant, Anne Bryans, Patrick Campbell, Vivian Jenkins, Egon Ronay, Norman Harris, Roy Shaw, David Blundy, John Boulting, Baris Schapiro, Frank Giles, Peter Kellner, Robin Marlar, Robert Troop, Cyril Connolly, Brian Moynahan, Malcolm Crawford Economics Editor, William Shawcross, Ivan Sutton, Dr Alfred Byrne, Peter Lennon, Leszek Kolakowski, John Ball, Arthur Eperon, Maxwell Boyd, Tony Geraghty, Brian Jackman, Nicholas Carroll, Anthony Storr, Financial Editor Graham Searjeant, Mavis Nicholson, John Hopkins, Ken Wilson, Derrik Mercer, Eric Marsden, Peter Wilsher, Haig Gudenian, Aziz Khan-Panni, Bryan Silcock, Roger Mortimer, Eric Jacobs, Malcolm Winton, James Wilson, Arnold Legh, John Raymond, Dan Van der Vat, R Brain, Desmond Shawe-Taylor, Gwen Nuttall, Julian Mackintosh, Michael Bateman, Stephen Aris, Patrick Rowley, Lanning Roper, Dilys Powell, Robert Birley, Elkan Allan, Dr Brian O'leary Assistant Professor of Astronomy at Cornell University, David Divine Defence Correspondent, John, Felix Aprahamian, Jack Fingleton, Stephen Fay, Peter Pringle, James Margach Political Correspondent, Godfrey Hadgson, John Coker, Joseph Bravshaw, Tony Dawe, Brian Glanville, Derek Humphry, Michael Moynihan, Keith Richardson, Molly Burkett, Taylor Woodrow, Michael Green, Tom Davies, C. H. O'd. Alexander, Maurice Wiggin, Michael Parkinson, Jacquetta Hawkes, Phillip Knightley, Allan Hall, Valerie Wade, Harlow Unger, Brenda Jones, Vincent Hanna, Muriel Bowen, David Attenborough,

How Fresh is your Food? If the Post Stays Stopped Cricket club uproar over Brain Close sacking Soviet agents try to cash £27 million German war loot bonds ...

1971 - Gale Group | Sunday Times HA GDA

Artigo Acesso aberto

Sławomir Kukliński, Lechosław Tomaszewski, Robert Kołakowski, Prosper Chemouil,

Network slicing is a relatively recent paradigm that has become a subject of intensive research. Most of the existing approaches follow the ETSI NFV MANO model with some extensions related to multi-domain slicing, slice selection, etc. The framework is a part of the standalone variant of the 5G network standardized by 3GPP. However, the current implementation of network slicing in 5G has several limitations, especially regarding management and orchestration: The isolation of slice management is ...

Tópico(s): Network Security and Intrusion Detection

2021 - Institute of Electrical and Electronics Engineers | Journal of Communications and Networks

Jornais Acesso aberto

Jeremy Rundall, Terry Delaney, Richard Buckle, James Margach, James Joll, John Fryer, Harold Hobson, Rob Hughes, Stanley Frederick, Jack Crimshaw, Nicholas Faith Deputy Editor of Business News, Kenneth Pearson, T J Coleman, Graham Rose, James Poole, (Mrs) I Bobak, Antony Terry, D A Bell, Lucia Van der Post, Julian Symons, Jason Tomas, C. I. Baldry, Michael Pilch, Mrs E. Spencer, (Dr) R G V Hahn, Henry Brandon, John Russell, Richard Milner, Brian James, Deryk Brown, Anthony Carson, Raymond Briggs, Derek Prouse, Philip Clarke, Derek Jewell, A. F. G. L, Vivian Jenkins, Murray Sayle, Bernard Sinnot, Brain Glanville, Jeremy Bundall, A McGregor, Tom Hutchinson, Sheila McNeil, Bryan Silcock Science Correspondent, Robert Troop, Lesley Garner, David Gibbons, Hugh Somerville, Cyril Connolly, Malcolm Crawford Economics Editor, H. F. Lovelock, Peter Lennon, Leszek Kolakowski, Mirabel D Topham, David Holden, Frank Brooks, Boris Scharpiro, John Milsom, Judith Jackson, Andrew Hale, Barbara Graeme, Allan Hall Editor, Dan Jacobson, Mrs P. E. Lord, John Hopkins, Eric Jacobs Labour Correspondent, Denis Herbstein, Eric Marsden, Peter Wilsher, John Whitley, Fraser Darling, Aziz Khan-Panni, Pamela Vandyke Price, Bryan Silcock, L V Rigley, Roger Mortimer, Eric Jacobs, L G D Croft, Cameron Hazlehurst, James Wilson, David Blake, Ernestine Carter, Michael Pye, R Brain, Desmond Shawe-Taylor, Alan Brien, Gwen Nuttall, Michael Wood, Michael Bateman, Jeremy Catto, Stephen Aris, Patrick Rowley, Lanning Roper, Jean Robertson, Herald, Antony Terry Bonn, Michael Kustow, Tony Rocca, Elkan Allan, Tony Osman, Brain James, Hugo Young, Dudley Doust, Felix Aprahamian, Jan Smith, David, Ivor Herbert, Barbara Robb Chairman, Mrs M. A. Whitaker, Peter George, Derek Humphry, Brian Glanville, Tony Dawe, Keith Richardson, Graham Searjeant, Peter Dunn, Michael Green, Wiltshire Gazette, Tom Davies, C. H. O'd. Alexander, Arthur Jacobs, Maurice Wiggin, (Mrs) J Barnet, Nicholas Faith, Clive Gammon, Peter Crookston, Brenda Jones, Jack Jones, Vincent Hanna, Michael Meacher, Frank Allaun Mp, Bill Tidy, Muriel Bowen, Nicholas Tomalin,

Greeks expel German envoy News Digest Today's rail travel still uncertain Police capture Ira leaders in Belfast Saigon troops retreat Unofficial Powell ...

1972 - Gale Group | Sunday Times HA GDA

Capítulo de livro Acesso aberto Revisado por pares

Lechosław Tomaszewski, Sławomir Kukliński, Robert Kołakowski,

This paper presents a concept of integration of MEC into the 5G network slicing architecture. Three variants of the architecture have been proposed, which incorporate: individual MEP/MEPM for each slice, shared ones for multiple network slices and Distributed Autonomous Slice Management and Orchestration (DASMO) approach. Each variant is focused on efficient integration of 5G Core and MEC solutions and utilizing additional functionalities of both components, including MEC APIs and 5G Control Plane ...

Tópico(s): IoT and Edge/Fog Computing

2020 - Springer Science+Business Media | IFIP advances in information and communication technology

Jornais Acesso aberto

Caroline Atkinson, Harry Verney Pensions Adviser, G E Parish, David Robson Editor, Rosemary Righter, Miles Kington, Will Ellsworth-Jones, Ronald Searle, Philip Norman, Chris Ryder, Rob Hughes, Dennis Potter, Jean Robertson Travel Editor, Peter Marson, Carolyn Chapman, Kenneth Pearson, Katharine Thwaites Writer, Berry Ritchie, Graham Rose, James Poole, Sheridan Morley, Antony Terry, Anne Redmon, Julian Symons, H B Snell, Dalbert Hallenstein, Jason Tomas, F K C Pike, Lady Alexandra Metcalfe, Carol Sarler, Zoe Dominic, Philip Oakes, Richard Eaton, Cate Haste, Peter Rodgers, Stuart Haverstock, Richard Milner, Paddy McGarvey, Daniel Karlin, Bernard Levin, Samuel Beckett, David Dougill, Joe Irving, John Clarke, Cliff Temple, Ivor Tilney, W Thelwell, Stan Newens Member, David Coward, Vivian Jenkins, Rosalind Gemal, Peter Rodgers Energy Editor, Jane Longman, David Cairns, John Illman, Norman Harris, Michael Hamilton, David Blundy, Kieran Gill, David Bonavia, Geoff Whitten, J B Priestley, Reuben Ainsztein, David Hare, Elizabeth Ray, Robert Troop, Robin Marlar, Liam Hudson, Peter Nichols, Elaine Davenport, Larry Rohter, R Smith, Denis Hamilton Chairman, Roger Eglin, Michael Nimmo, Catherine T. Gent, Peter Lennon, John Ball, Boris Schapiro, Terry Jennings, Brian Jackman, Judith Jackson, Richard Girling, F R Mountain, Colin Mackay, Claire Tomalin, John Fryer Labour Correspondent, John Walker, Suzanne Hodgart, John Hopkins, John Barnes, Derrik Mercer, Denis Herbstein, N. Torrents Lecturer and Tutor, Eric Marsden, John Whitley, Hugo Young Political Editor, Eric Jacobs, Edward Bond, James Wilson, Ruth Cale, Peter Stothard, Michael Pye, David May, Robert David McDonald, Jeremy Brooks, Terry Burns, Flaw, Alan Brien, Russell Davies, Gwen Nuttall, David Scott, Stephen Aris, Jane Henderson, Patrick Rowley, Dilys Powell, John Bell City Editor, John Lovesey, Alan Budd, Bill Cater, Brough Scott, Christopher Fry, Oliver Gillie, Oliver Gillie Medical Correspondent, Kenneth Fleet, Elkan Allan, Clive Everton, Gordon Burn, Bryan Rostron, Stuart Alexander, Tony Osman, Richard Hughes, Rob Rohrer, Peter Gill, Dudley Doust, Ian Nairn, Alison Miller, James Wootten, Peter Wilby, Luck, Ian Jack, Matthew Hoffman, Stephen Fay, Peter Collins, Peter Clarke, Phillida Gubbins, Andrew Stephen, Brian Glanville, John Carey, Michael Coveney, Michael Roberts, George Steiner, Michael Green, D. Wilkinson, Peter James, Kenneth Fleet Editor, A Edwin D Fleming, Emlya Williams, Victor Bryant, Linda Melvern, Marina Vaizey, Michael de Larrabeiti, Phillip Knightley, Robert Whymant, Philip Jacobson, Patience Wheatcroft, Eldon Griffiths Member for Bury St Edmunds, Muriel Bowen,

... Sports John Morgan Travel Multiple Classified Advertising Items Robert Cohan's ... of Marxism by Leszek Kolakowski 3 vols: The Founders (£7.95 pp 434); ...

1978 - Gale Group | Sunday Times HA GDA

Capítulo de livro Revisado por pares

Lechosław Tomaszewski, Robert Kołakowski, M. Zagórda,

The multiple capabilities offered by the 5G network have significantly accelerated the expansion of the service portfolio of telecommunication operators. The future mobile network is expected to elevate these possibilities to an even higher level. Enormous data rate, near-to-zero latency and huge density of devices will allow for building robust and innovative ecosystems providing specialized services to the vertical industries. Moreover, the progress in network expansion towards the edge has facilitated ...

Tópico(s): Advanced Wireless Communication Technologies

2022 - Springer Science+Business Media | IFIP advances in information and communication technology

Artigo Revisado por pares

Robert V. Kolakowski, Karl T. Haelsig, Kim K. Emmerton, Chris Leiske, Jamie B. Miyamoto, Julia H. Cochran, Robert P. Lyon, Peter D. Senter, Scott C. Jeffrey,

Abstract A strategy for the conjugation of alcohol‐containing payloads to antibodies has been developed and involves the methylene alkoxy carbamate (MAC) self‐immolative unit. A series of MAC β‐glucuronide model constructs were prepared to evaluate stability and enzymatic release, and the results demonstrated high stability at physiological pH in a substitution‐dependent manner. All the MAC model compounds efficiently released alcohol drug surrogates under the action of β‐glucuronidase. To assess ...

Tópico(s): Glycosylation and Glycoproteins Research

2016 - Wiley | Angewandte Chemie International Edition

Jornais Acesso aberto

Jeremy Andrews, Rosemary Righter, Jocelyn Haines, G. Bowman, Bob Ross, Mike Graham, Sheila Gunn, S. Murray, Case Judd, Christopher Warman, Property Correspondent, Mary Delorne, Anne Billson, W. S. Allen, Melvyn Harris, Neil Bennett, Gordon Allan, Mark Souster, Ronald Faux, Cliff Feltham, Mr George Curtis, Ivo Tennant, Douglas Broom, Education Reporter, Owen Stable, Michael Seely, Racing Correspondent, Philip Howard, Carol Leonard, Richard Streeton, Joanathan Goldsmith, Nicholas Wood and Michael Dynes, Tony Patrick, Edmond Jackson, Henry Gee, Bryan Stiles, Yehudi Menuhin, Robin Stacey and Geoff King, Nicholas Bethell Chairman, John Lewis, Political Staff, Norman Hammond, Archaeology Correspondent, Peter Ball, Michael Knipe, Raymond Keene Chess Correspondent, Scrivener, Louise Taylor, Martin Cropper, Alan Hamilton, John Young, Robin Young and Geoff King, Mark Souster and Michael Dynes, John Percival, Charles P. Reed, Geoffrey Matthews, Neil Wright, Quentin Cowdry Home Affairs Correspondent, Steven Downes, Edward Fennell, Sally Watts, Richard Evans and David Sapsted, Michael Theodoulou, Sydney Friskin, Geoffrey Wheeler, A. I. Miller, William Greaves, David Toop, Catherine Sampson, Bryn Appleyard, R. H. Grierson Executive Chairman, Peter Davalle, Dr John Baldwin, Nicholas Beeston, Emma Wilkins, John Russell Taylor, Dennis Shaw, Louise Taylor and Ian Ross, Alan Lee, Cricket Correspondent, Peter Bryan, Martin Searby, Adrian Rogers, Pat Butcher, Roger Boyes, Roger Boyes Warsa, Leszek Kolakkowski, John Bell City Editor, Richard Bassett, David Hands Rugby Correspondent, David Tang, Christopher Thomas, John Goodbody, J. R. Drewer, John Meinferelith Drummond, Mandarin, Peter Aykroyd, Eric Balfry, George Curtis, Algy Cluff, William Mackean, Paul Newman, Liz Smith, Hubert Andrew, David Davies, Keith Blackmore, Michael Austin, Alan Lee, Michael Dynes, Martin Waller, Alan Coren, Rodney Lord, Economics Editor, Pat Butcher Athletics Correspondent, Richard Morrison, Jack Bailey, Derek Harris Industrial Editor, Pearce Wright, Science Editor, Colin Campbell, Geofrey Matthews, Jan Raath, David Hands, Rugby Correspondent, Rodney Lord Economics Editor, Douglas W. Wren, Mary Dejevsky,

... workers' ally will have to be tough Leszek Kolakowski assesses Solidarity's chances of success in the ... Stock Watch The Times Legal Appointments Legal Resources Robert Walters Associates Speculation lifts Fisons after bid for ...

1989 - Gale Group | TDA

Artigo Revisado por pares

Robert V. Kolakowski, Thomas D. Young, Philip W. Howard, Scott C. Jeffrey, Peter D. Senter,

We disclose the synthesis of a versatile C2-aryl-pyrrolo[2,1-c][1,4]benzodiazepine (PBD) monomer that enables the late-stage diversification and synthesis of PBD dimers. The monomer unit was elaborated and dimerized utilizing different tethers to yield symmetric and non-symmetrical C2-aryl-PBD dimers. The dimers were tested for cytotoxic activity on a number of cancer cell lines and showed potent cytotoxicity in the nanomolar to picomolar range. The synthesis of PBD monomers enables the modular construction ...

Tópico(s): Cancer therapeutics and mechanisms

2015 - Elsevier BV | Tetrahedron Letters

Artigo Revisado por pares

Robert V. Kolakowski, Madhuri Manpadi, Yue Zhang, Thomas J. Emge, Lawrence J. Williams,

A new method of allene synthesis is described. Suitably functionalized vinyl triflates undergo fragmentation to give allenes in high yield. Computational and experimental data provide a mechanistic framework for allene formation and the complementary formation of alkynes. The method is stereospecific.

Tópico(s): Catalytic C–H Functionalization Methods

2009 - American Chemical Society | Journal of the American Chemical Society

Artigo Revisado por pares

Robert V. Kolakowski, Lawrence J. Williams,

The synthesis of the C21–C28 segment of pectenotoxin-4 as the C21 Weinreb amide is described. Feasibility studies for the union of a related Weinreb amide and a functionalized alkyne are also reported.

Tópico(s): Synthetic Organic Chemistry Methods

2007 - Elsevier BV | Tetrahedron Letters

Jornais Acesso aberto

Glasgow Govan, Jeremy Rundall, Julian Gibbs Chairman, Edward Lucie-Smith, Terry Delaney, Richard Buckle, James Margach, Edinburgh North, Philip Norman, Harold Hobson, Chris Ryder, Mike Bygrave, John Peter, Lord Campbell, James Poole, Frank Sanderson, A J P Townend, Antony Terry, John Whale, Julian Symons, Frederic Raphael, R. F. Richardson, Jason Tomas, Gerald Fitzgibbon, Barbara Wace, Philip Oakes, Henry Brandon, Richard Milner, Antony Gibbs, Brian James, Deryk Brown, Lord Chandos, Philip Clarke, Derek Jewell, Edward James, Patrick Campbell, Vivian Jenkins, Peter Watson, Wendy Hughes, David Cairns, Beata Lipmann, Norman Harris, Richard Cobb, Geoff Whitten, Michael Jones, Peter Kellner, Mary Burrell, Robin Marlar, Hugh Somerville, Robert Samuelson, Cyril Connolly, Brian Moynahan, Roger Eglin, Franklyn Wood, Paul Marshall, Peter Lennon, Michael Howard, Marjorie Wallace, David Holden, Maxwell Boyd, Tony Geraghty, John Farthing, John Fryer Labour Correspondent, Anthony Storr, John Hopkins, Celia Haddon, S H Davis, Robert Lacey, James Fox, John Bloom, Bryan Silcock, Roger Mortimer, Eric Jacobs, Malcolm Winton, Walter Isaacson, Meriel McCooey, Ted Clark, Gwen Nuttall, John Bell, Stephen Aris, Ronald Legge, Lanning Roper, Jean Robertson, Dilys Powell, Hugh Johnson, Brough Scott, Tony Rocca, Oliver Gillie, Elkan Allan, (Sir) James Richards, Ian Gorman, Dudley Doust, Ian Nairn, Felix Aprahamian, Ian Jack, Margaret Costa, Andy Privett, John Mapplebeck, A G Cadman, William Low, Alex Cohen, Eve Arnold, James Margach Political Correspondent, Tony Crook, (Dr) Colin P Groves, Derek Humphry, Michael Moynihan, Lord Devlin, Brian Glanville, Keith Richardson, Peter Dunn, Victor Lewis, Michael Green, C. H. O'd. Alexander, Nicholas Faith, Doris Langley Moore, (Mrs) Nan C Lewin, Michael Parkinson, George, Roman Eisenstein, (Rev.) W D Laird, Chris Lightbown, Saeed Naqvi, Michael Stuart, Allan Hall, Valerie Wade, I T McLean, Malcolm Crawford, Philip Jacobson, Mark Amory, Peter Ryde, Tom Shaw, Hugh Trevor-Roper, Boris Schapiro,

... in earnest The Devil and Scripture by Leszek Kolakowski/Oxford £2.50 Short Reports Prophet at large ...

1973 - Gale Group | Sunday Times HA GDA

Artigo Revisado por pares

Kristin N. Barlett, Robert V. Kolakowski, Sreenivas Katukojvala, Lawrence J. Williams,

A one-pot procedure for the conversion of carboxylic acids to N-acyl sulfonamides, via thio acid/azide amidation, is presented. The method is compatible with acid- and base-sensitive amino acid protection. N-Acyl sulfonamide synthesis on solid support, peptide thio acid/sulfonazide coupling, and N-alkyl amide synthesis via selective cleavage of sulfonyl from an N-alkyl-N-acyl sulfonamide are also reported.

Tópico(s): Click Chemistry and Applications

2006 - American Chemical Society | Organic Letters

Artigo Revisado por pares

Robert V. Kolakowski, Ning Shangguan, Lawrence J. Williams,

A method for thioamide formation from dithioacids and azides is described and a mechanistic framework is presented.

Tópico(s): Synthesis and Characterization of Heterocyclic Compounds

2006 - Elsevier BV | Tetrahedron Letters

Jornais Acesso aberto

Geoffrey Grigson, Audrey Slaughter, Leslie Duckworth, John Shirley, Rio de Janeiro, Raymond Mander, Charles Raw, John Fryer, Jim Tucker, George Felton Mathew, Chris Ryder, Rob Hughes, Christian Jenner, John Peter, Peter Marson, Crispin Aubrey, Nick Gilbert Deputy City Editor, Martin Leighton, Michael Finnissy, Berry Ritchie, Graham Rose, Robin Morgan, Michael Binyon, John Whale, Nick Pitt, Jason Tomas, Bruce Kennedy, Dessa Trevisan, Colin Simpson, Diana Winsor, Richard Milner, David Dougill, Mitchell Platts, Joe Irving, Veronica Horwell, Cliff Temple, Derek Jewell, Robert Gittings, Patrick Carnegy, David Cairns, Adrianne Blue, Norman Harris, Julia Elton, Geoff Whitten, Peter Ackroyd, Peter Kellner, Robin Marlar, Robert Troop, Lesley Garner, Larry Rohter, John Sheppard, P. B. D. Bunyan Parliamentary Affairs Officer, Anthony Bailey, Helen Boswell, Gillian Darley, Patrick Forman, John Keegan, Andrew Cornelius, James Tucker, John Oakeley, Leszek Kolakowski, Lorana Sullivan, Paul Driver, Marjorie Wallace, David Hughes, George Melly, Ulick O'Connor, Richard Girling, Nick Gilbert, Suzanne Hodgart, Alex Raymond, Nigel Harvey, Geoffrey Young, Eric Marsden, Stephen Wood, Marcus Binney, Bryan Silcock, Simon Freeman, Mrs N Silkin, Stephen Pile, Gareth Huw Davies, Chris Lighthown, Ruth Cale, Peter Stothard, Nigel Osborne, Alan Ryan, Alan Thornton Director, Jeremy Treglown, R W Spiers, Betka Zamoyska, Russell Davies, Marcus Rinney, Clive Aslet, Geoff Aspel, Jean Robertson, Clive Branson, David Preiskel, Dilys Powell, Kenneth Hudson, Brough Scott, Oliver Gillie Medical Correspondent, Laurel Ball, Dudley Doust, Felix Aprahamian, Ian Nairn, Peter Wilby, J W Lambert, Lewis Chester, Mary Davis Peters, Peter Clarke, Peter Pringle, Andrew Stephen, Chris Oram, Michael Dobbs, Eugene Bacot, Brian Glanville, John Carey, Joe Mitchenson, Keith Richardson, Dianne Core, Graham Searjeant, Caroline Silver, Peter Dunn, Michael Roberts, James Fenton, Denis Lehane, John Pasiecznik, Michael Parkinson, Andrey Slaughter, Marina Vaizey, Chris Lightbown, Jan Mayman, Tony Geraghty Defence Correspondent, Malcolm Crawford, Peter Dickson Teacher, Patience Wheatcroft, Roger Ratcliffe, Michael Heath, Boris Schapiro, Judy Dempsey, George Benjamin,

Agencies: Peace men shell city News Digest 24 August 1980 Japan in nuclear sub protest Iran exiles talk Troops accused Aboriginal appeal Dizzy blonde? ...

1980 - Gale Group | Sunday Times HA GDA

Artigo Revisado por pares

Robert V. Kolakowski, Ning Shangguan, Ronald R. Sauers, Lawrence J. Williams,

A combined experimental and computational mechanistic study of amide formation from thio acids and azides is described. The data support two distinct mechanistic pathways dependent on the electronic character of the azide component. Relatively electron-rich azides undergo bimolecular coupling with thiocarboxylates via an anion-accelerated [3+2] cycloaddition to give a thiatriazoline. Highly electron-poor azides couple via bimolecular union of the terminal nitrogen of the azide with sulfur of the ...

Tópico(s): Chemical Synthesis and Analysis

2006 - American Chemical Society | Journal of the American Chemical Society