Riccardo Giudici, Armando Lancioni, Hedwige Gay, Gabriele Bassi, Osvaldo Chiara, Claudio Mare, Nicola Latronico, Antonio Artigas, Roberto Faccincani, Luca Cabrini, Roberto Fumagalli, Arturo Chieregato, Laura Briani, Fabrizio Sammartano, Giuseppe Maria Sechi, Alberto Zoli, Andrea Pagliosa, Giuseppe Foti, Erika Borotto, Alessandra Palo, Oliviero Valoti, Marco Botteri, Michele Carlucci, Elisa Reitano, Roberto Bini,
The COVID-19 pandemic drastically strained the health systems worldwide, obligating the reassessment of how healthcare is delivered. In Lombardia, Italy, a Regional Emergency Committee (REC) was established and the regional health system reorganized, with only three hospitals designated as hubs for trauma care. The aim of this study was to evaluate the effects of this reorganization of regional care, comparing the distribution of patients before and during the COVID-19 outbreak and to describe changes ...
Tópico(s): Emergency and Acute Care Studies
2021 - BioMed Central | World Journal of Emergency Surgery
Eleonora Brognara, Enrica Fabbri, Elena Bazzoli, Giulia Montagner, Claudio Ghimenton, Albino Eccher, Cinzia Cantù, Alex Manicardi, Nicoletta Bianchi, Alessia Finotti, Giulia Breveglieri, Monica Borgatti, Roberto Corradini, Valentino Bezzerri, Giulio Cabrini, Roberto Gambari,
Tópico(s): Circular RNAs in diseases
2014 - Springer Science+Business Media | Journal of Neuro-Oncology
Shaiq Sultan, Andrea Rozzi, Jessica Gasparello, Alex Manicardi, Roberto Corradini, Chiara Papi, Alessia Finotti, Ilaria Lampronti, Eva Reali, Giulio Cabrini, Roberto Gambari, Monica Borgatti,
Peptide nucleic acids (PNAs) have been demonstrated to be very useful tools for gene regulation at different levels and with different mechanisms of action. In the last few years the use of PNAs for targeting microRNAs (anti-miRNA PNAs) has provided impressive advancements. In particular, targeting of microRNAs involved in the repression of the expression of the cystic fibrosis transmembrane conductance regulator (CFTR) gene, which is defective in cystic fibrosis (CF), is a key step in the development ...
Tópico(s): MicroRNA in disease regulation
2020 - Multidisciplinary Digital Publishing Institute | Molecules
Enrica Fabbri, Anna Tamanini, Tiziana Jakova, Jessica Gasparello, Alex Manicardi, Roberto Corradini, Alessia Finotti, Monica Borgatti, Ilaria Lampronti, Silvia Munari, Maria Cristina Dechecchi, Giulio Cabrini, Roberto Gambari,
Since the identification of microRNAs (miRNAs) involved in the regulation of Cystic Fibrosis Transmembrane Conductance Regulator (CFTR) gene, miRNAs known to down-regulate the expression of the CFTR and associated proteins have been investigated as potential therapeutic targets. Here we show that miR-101-3p, targeting the 3′-UTR sequence of the CFTR mRNA, can be selectively inhibited by a peptide nucleic acid (PNA) carrying a full complementary sequence. With respect to clinical relevance of microRNA ...
Tópico(s): RNA Interference and Gene Delivery
2020 - Elsevier BV | European Journal of Medicinal Chemistry
Enrica Fabbri, Anna Tamanini, Tiziana Jakova, Jessica Gasparello, Alex Manicardi, Roberto Corradini, G Sabbioni, Alessia Finotti, Monica Borgatti, Ilaria Lampronti, Silvia Munari, Maria Cristina Dechecchi, Giulio Cabrini, Roberto Gambari,
Peptide nucleic acids (PNAs) are very useful tools for gene regulation at different levels, but in particular in the last years their use for targeting microRNA (anti-miR PNAs) has provided impressive advancements. In this respect, microRNAs related to the repression of cystic fibrosis transmembrane conductance regulator (CFTR) gene, which is defective in cystic fibrosis, are of great importance in the development of new type of treatments. In this paper we propose the use of an anti-miR PNA for targeting ...
Tópico(s): MicroRNA in disease regulation
2017 - Multidisciplinary Digital Publishing Institute | Molecules
Roberta Milani, Eleonora Brognara, Enrica Fabbri, Alex Manicardi, Roberto Corradini, Alessia Finotti, Jessica Gasparello, Monica Borgatti, Lucia Carmela Cosenza, Ilaria Lampronti, Maria Cristina Dechecchi, Giulio Cabrini, Roberto Gambari,
The present study investigated the effects of the combined treatment of two peptide nucleic acids (PNAs), directed against microRNAs involved in caspase‑3 mRNA regulation (miR‑155‑5p and miR‑221‑3p) in the temozolomide (TMZ)‑resistant T98G glioma cell line. These PNAs were conjugated with an octaarginine tail in order to obtain an efficient delivery to treated cells. The effects of singularly administered PNAs or a combined treatment with both PNAs were examined on apoptosis, with the aim to determine ...
Tópico(s): RNA Research and Splicing
2019 - Spandidos Publishing | International Journal of Oncology
Eleonora Brognara, Enrica Fabbri, Giulia Montagner, Jessica Gasparello, Alex Manicardi, Roberto Corradini, Nicoletta Bianchi, Alessia Finotti, Giulia Breveglieri, Monica Borgatti, Ilaria Lampronti, Roberta Milani, Maria Cristina Dechecchi, Giulio Cabrini, Roberto Gambari,
The biological activity of a combined treatment of U251, U373 and T98G glioma cell lines with two anti-miR PNAs, directed against miR‑221 and miR‑222 and conjugated with an ocataarginine tail (R8-PNA-a221 and R8-PNA-a222) for efficient cellular delivery, was determined. Apoptosis was analyzed, and the effect of the combined treatment of glioma cells with either or both PNAs on the reversion of drug-resistance phenotype was assessed in the temozolomide-resistant T98G glioma cell line. Selectivity ...
Tópico(s): DNA and Nucleic Acid Chemistry
2015 - Spandidos Publishing | International Journal of Oncology
Valentino Bezzerri, Valentina Gentili, Martina Api, Alessia Finotti, Chiara Papi, Anna Tamanini, Christian Boni, Elena Baldisseri, Debora Olioso, Martina Duca, Erika Tedesco, Laura S. Leo, Monica Borgatti, Sonia Volpi, Paolo Pinton, Giulio Cabrini, Roberto Gambari, Francesco Blasi, Giuseppe Lippi, Alessandro Rimessi, Roberta Rizzo, Marco Cipolli,
Abstract As an inherited disorder characterized by severe pulmonary disease, cystic fibrosis could be considered a comorbidity for coronavirus disease 2019. Instead, current clinical evidence seems to be heading in the opposite direction. To clarify whether host factors expressed by the Cystic Fibrosis epithelia may influence coronavirus disease 2019 progression, here we describe the expression of SARS-CoV-2 receptors in primary airway epithelial cells. We show that angiotensin converting enzyme ...
Tópico(s): Respiratory viral infections research
2023 - Nature Portfolio | Nature Communications
Ilaria Lampronti, Maria Giulia Manzione, Gianni Sacchetti, Davide Ferrari, Susanna Spisani, Valentino Bezzerri, Alessia Finotti, Monica Borgatti, Maria Cristina Dechecchi, Giorgia Miolo, Giovanni Marzaro, Giulio Cabrini, Roberto Gambari, Adriana Chilin,
The angelicin analogue 4,6,4′-trimethylangelicin (TMA) was recently reported as a strong inhibitor of nuclear factor- κ B (NF- κ B) activity and of the expression of the interleukin-8 (IL-8) gene in bronchial epithelial cells in which the inflammatory response has been challenged with P. aeruginosa , the most common bacterium found in the airways of patients affected by cystic fibrosis (CF). These findings encouraged us to analyze new synthetic analogues of TMA in order to evaluate their biological activities ...
Tópico(s): Antifungal resistance and susceptibility
2017 - Hindawi Publishing Corporation | Mediators of Inflammation
Enrica Fabbri, Giulia Montagner, Nicoletta Bianchi, Alessia Finotti, Monica Borgatti, Ilaria Lampronti, Giulio Cabrini, Roberto Gambari,
The role of the microRNA miR-93-5p on the secretome profile and the expression levels of vascular endothelial growth factor (VEGF) and interleukin-8 (IL-8) was investigated in the neuroblastoma SK-N-AS cell line by Bio-Plex analysis and RT-qPCR. The results indicate that VEGF and IL-8 are the major miR-93-5p molecular targets. This conclusion was based on in vitro transfection with pre-miR-93-5p and anti-miR-93-5p; these treatments inversely modulated both VEGF and IL-8 gene expression and protein ...
Tópico(s): interferon and immune responses
2016 - Elsevier BV | Oncology Reports
Laura Pasin, Pasquale Nardelli, Alessandro Belletti, Massimiliano Greco, Giovanni Landoni, Luca Cabrini, Roberto Chiesa, Alberto Zangrillo,
Objectives Postoperative pulmonary complications (PPC) are among the most common complications after noncardiac surgery. Men, smokers, and elderly patients with chronic obstructive pulmonary disease or heart failure are more likely to experience PPC. The majority of patients undergoing vascular surgery belong in these categories and are at higher risk of developing PPC. Moreover, the surgical site is one of the most important risk factors associated with PPC, and aortic surgery carries the highest ...
Tópico(s): Aortic aneurysm repair treatments
2016 - Elsevier BV | Journal of Cardiothoracic and Vascular Anesthesia
Enrica Fabbri, Eleonora Brognara, Giulia Montagner, Claudio Ghimenton, Albino Eccher, Cinzia Cantù, Susanna Khalil, Valentino Bezzerri, Lisa Provezza, Nicoletta Bianchi, Alessia Finotti, Monica Borgatti, Giuseppe Moretto, Marco Chilosi, Giulio Cabrini, Roberto Gambari,
Different strategies have been proposed to target neoangiogenesis in gliomas, besides those targeting Vascular Endothelial Growth Factor (VEGF). The chemokine Interleukin-8 (IL-8) has been shown to possess both tumorigenic and proangiogenic properties. Although different pathways of induction of IL-8 gene expression have been already elucidated, few data are available on its post-transcriptional regulation in gliomas. Here we investigated the role of the microRNA miR-93 on the expression levels of ...
Tópico(s): Circular RNAs in diseases
2015 - BioMed Central | BMC Cancer
Valentino Bezzerri, Concetta Avitabile, Maria Cristina Dechecchi, Ilaria Lampronti, Monica Borgatti, Giulia Montagner, Giulio Cabrini, Roberto Gambari, Alessandra Romanelli,
Natural peptides with antimicrobial properties are deeply investigated as tools to fight bacteria resistant to common antibiotics. Small peptides, as those belonging to the temporin family, are very attractive because their activity can easily be tuned after small modification to their primary sequence. Structure-activity studies previously reported by us allowed the identification of one peptide, analogue of temporin B, TB_KKG6A, showing, unlike temporin B, antimicrobial activity against both Gram- ...
Tópico(s): Asthma and respiratory diseases
2014 - Wiley | Journal of Peptide Science
Enrica Fabbri, Monica Borgatti, Giulia Montagner, Nicoletta Bianchi, Alessia Finotti, Ilaria Lampronti, Valentino Bezzerri, Maria Cristina Dechecchi, Giulio Cabrini, Roberto Gambari,
Section:ChooseTop of pageAbstract <<Materials and MethodsResultsDiscussionReferencesCITING ARTICLES
Tópico(s): Neuroinflammation and Neurodegeneration Mechanisms
2014 - American Thoracic Society | American Journal of Respiratory Cell and Molecular Biology
Laura Piccagli, Monica Borgatti, Elena Nicolis, Nicoletta Bianchi, Irene Mancini, Ilaria Lampronti, Daniela Vevaldi, Francesco Dall’Acqua, Giulio Cabrini, Roberto Gambari,
Tópico(s): NF-κB Signaling Pathways
2010 - Elsevier BV | Bioorganic & Medicinal Chemistry
Anna Tamanini, Monica Borgatti, Alessia Finotti, Laura Piccagli, Valentino Bezzerri, Maria Favia, Lorenzo Guerra, Ilaria Lampronti, Nicoletta Bianchi, Francesco Dall’Acqua, Daniela Vedaldi, Alessia Salvador, Enrica Fabbri, Irene Mancini, Elena Nicolis, Valeria Casavola, Giulio Cabrini, Roberto Gambari,
Chronic inflammatory response in the airway tract of patients affected by cystic fibrosis is characterized by an excessive recruitment of neutrophils to the bronchial lumina, driven by the chemokine interleukin (IL)-8. We previously found that 5-methoxypsoralen reduces Pseudomonas aeruginosa-dependent IL-8 transcription in bronchial epithelial cell lines, with an IC(50) of 10 μM (Nicolis E, Lampronti I, Dechecchi MC, Borgatti M, Tamanini A, Bezzerri V, Bianchi N, Mazzon M, Mancini I, Giri MG, Rizzotti ...
Tópico(s): NF-κB Signaling Pathways
2010 - American Physical Society | AJP Lung Cellular and Molecular Physiology
Laura Piccagli, Enrica Fabbri, Monica Borgatti, Valentino Bezzerri, Irene Mancini, Elena Nicolis, Maria Cristina Dechecchi, Ilaria Lampronti, Giulio Cabrini, Roberto Gambari,
Abstract Background The transcription factor NF-kappaB is a very interesting target molecule for the design on anti-tumor, anti-inflammatory and pro-apoptotic drugs. However, the application of the widely-used molecular docking computational method for the virtual screening of chemical libraries on NF-kappaB is not yet reported in literature. Docking studies on a dataset of 27 molecules from extracts of two different medicinal plants to NF-kappaB-p50 were performed with the purpose of developing ...
Tópico(s): Immune Response and Inflammation
2008 - BioMed Central | BMC Structural Biology
Monica Borgatti, Valentino Bezzerri, Irene Mancini, Elena Nicolis, Maria Cristina Dechecchi, Ilaria Lampronti, Paolo Rizzotti, Giulio Cabrini, Roberto Gambari,
Cystic fibrosis (CF) is a genetic disease characterized by chronic bacterial lung infection, most commonly sustained by Pseudomonas aeruginosa. Upon infection, elevated concentrations of pro-inflammatory cytokines (i.e. IL-6 and IL1β) and chemokines (i.e. IL-8 and GROγ) are found in the bronchoalveolar fluid of CF patients. We report in this paper that: (a) IL-8, IL-6, IL-1β, ICAM-1, and GRO-γ genes are upregulated following infection of CF bronchial epithelial IB3-1 cells with P. aeruginosa; (b) Sp1 ...
Tópico(s): Pediatric health and respiratory diseases
2007 - Elsevier BV | Biochemical and Biophysical Research Communications
Laura Piccagli, Enrica Fabbri, Monica Borgatti, Nicoletta Bianchi, Valentino Bezzerri, Irene Mancini, Elena Nicolis, Cristina M. Dechecchi, Ilaria Lampronti, Giulio Cabrini, Roberto Gambari,
Abstract Virtual screening against NF‐κB p50 using docking simulations was applied by starting from a three‐dimensional (3D) database containing more than 4.6 million commercially available structures. This database was filtered by specifying a subset of commercially available compounds sharing a (2 E , Z )‐3‐(2‐hydroxyphenyl)‐2‐propenoate substructure and relevant druglike properties. Docking to p50 NF‐κB was performed with a test set of six known inhibitors of NF‐κB–DNA interactions. In agreement with ...
Tópico(s): RNA regulation and disease
2009 - Wiley | ChemMedChem
Chiara Papi, Jessica Gasparello, Matteo Zurlo, Alex Manicardi, Roberto Corradini, Giulio Cabrini, Roberto Gambari, Alessia Finotti,
The Cystic Fibrosis Transmembrane Conductance Regulator (CFTR) gene encodes for a chloride channel defective in Cystic Fibrosis (CF). Accordingly, upregulation of its expression might be relevant for the development of therapeutic protocols for CF. MicroRNAs are deeply involved in the CFTR regulation and their targeting with miRNA inhibitors (including those based on Peptide Nucleic Acids, PNAs)is associated with CFTR upregulation. Targeting of miR-145-5p, miR-101-3p, and miR-335-5p with antisense ...
Tópico(s): MicroRNA in disease regulation
2022 - Multidisciplinary Digital Publishing Institute | International Journal of Molecular Sciences
Alessia Finotti, Jessica Gasparello, Enrica Fabbri, Anna Tamanini, Roberto Corradini, Maria Cristina Dechecchi, Giulio Cabrini, Roberto Gambari,
group (P = 0.0053), suggesting a directly nephroprotective role of NO.However, no assesment of right heart function and no detailed hemodynamic measurements were presented.To determine both the cardiac and renal protective effects of NO during cardiac surgery and the potential cardio-renal interactions that might occur, we are now conducting a randomized trial in 250 cardiac surgery patients at the Massachusetts General Hospital (Boston, MA) with intraoperative echocardiography and pulmonary artery ...
Tópico(s): MicroRNA in disease regulation
2019 - American Thoracic Society | American Journal of Respiratory and Critical Care Medicine
Produção Nacional
Revisado por pares
Renata Cristiane dos Reis, Haissa Oliveira Brito, Daniel Fraga, Daniela Almeida Cabrini, Aleksander Roberto Zampronio,
Substance P (SP) is a neuropeptide that can modulate inflammatory mediator release through activation of NK(1) receptors (NK(1)R). Some studies have also suggested the involvement of SP in lipopolysaccharide (LPS)-induced fever. However, the precise contribution of this neuropeptide to the pathways activated during fever is unknown. In this study we investigated the effect of a selective NK(1)R antagonist, SR140333B, on the febrile response induced by LPS and cytokines. Our results show that the systemic ...
Tópico(s): Immune Response and Inflammation
2011 - Elsevier BV | Brain Research
Produção Nacional
Revisado por pares
Evelise Fernandes Pietrovski, Michel Fleith Otuki, D. Regoli, Michael Bäder, João Bosco Pesquero, Daniela Almeida Cabrini, Aleksander Roberto Zampronio,
Peptide and non-peptide kinin receptor antagonists were evaluated in cutaneous inflammation models in mice. Topical and i.p. application of kinin B(1) and B(2) receptor antagonists caused a significant inhibition of the capsaicin-induced cutaneous neurogenic inflammatory response. The calculated mean ID(50) for Hoe140 and SSR240612 were 23.83 (9.14-62.14) nmol/kg and 0.23 (0.15-0.36) mg/ear, respectively. The I(max) observed for Hoe140, SSR240612, R-715, FR173657, and FR plus SSR were 61+/-5%, 56+/- ...
Tópico(s): Urticaria and Related Conditions
2008 - Elsevier BV | Regulatory Peptides
Anna Tamanini, Enrica Fabbri, Tiziana Jakova, Jessica Gasparello, Alex Manicardi, Roberto Corradini, Alessia Finotti, Monica Borgatti, Ilaria Lampronti, Silvia Munari, Maria Cristina Dechecchi, Giulio Cabrini, Roberto Gambari,
(1) Background: Up-regulation of the Cystic Fibrosis Transmembrane Conductance Regulator gene (CFTR) might be of great relevance for the development of therapeutic protocols for cystic fibrosis (CF). MicroRNAs are deeply involved in the regulation of CFTR and scaffolding proteins (such as NHERF1, NHERF2 and Ezrin). (2) Methods: Content of miRNAs and mRNAs was analyzed by RT-qPCR, while the CFTR and NHERF1 production was analyzed by Western blotting. (3) Results: The results here described show that the ...
Tópico(s): RNA Interference and Gene Delivery
2021 - Multidisciplinary Digital Publishing Institute | Biomedicines
Produção Nacional
Revisado por pares
Marina Reis Oliveira, Andréa Gonçalves, Marisa Aparecida Cabrini Gabrielli, Cléverton Roberto de Andrade, Eduardo Hochuli‐Vieira, Valfrido Antônio Pereira-Filho,
Objectives: This study evaluated the bone quality of the maxilla and mandible by using the classification proposed by Lekholm and Zarb (L & Z) and histomorphometry. Methods: Sixty edentulous areas were evaluated. The classification by L & Z was obtained through the evaluation of periapical and panoramic radiographs associated with the surgeon's tactile perception during milling and implant installation. Before implant installation, bone biopsies of standardized sizes were performed for histological evaluation. ...
Tópico(s): Dental Implant Techniques and Outcomes
2021 - Lippincott Williams & Wilkins | Journal of Craniofacial Surgery
Luis J. V. Galietta, Patrick Pagésy, Chiara Folli, Emanuela Caci, Leila Romio, Bruno Costes, Elena Nicolis, Giulio Cabrini, M. Goossens, Roberto Ravazzolo, Olga Zegarra‐Moran,
Abstract Recent data show that proinflammatory stimuli may modify significantly ion transport in the airway epithelium and therefore the properties of the airway surface fluid. We have studied the effect of IL-4, a cytokine involved in the pathogenesis of asthma, on transepithelial ion transport in the human bronchial epithelium in vitro. Incubation of polarized bronchial epithelial cells with IL-4 for 6–48 h causes a marked inhibition of the amiloride-sensitive Na+ channel as measured in short ...
Tópico(s): Asthma and respiratory diseases
2002 - American Association of Immunologists | The Journal of Immunology
Ferdinando Bedeschi, Rich Fackenthal, Claudio Resta, Enzo Michele Donze, Meenatchi Jagasivamani, E. Buda, F. Pellizzer, David W. Chow, A. Cabrini, G Calvi, Roberto Faravelli, A. Fantini, G. Torelli, D. Mills, Roberto Gastaldi, G. Casagrande,
In this paper, a 90-nm 128-Mcell non-volatile memory based on phase-change ${\hbox{Ge}}_{2}\mathchar"707B {\hbox{Sb}}_{2}\mathchar"707B {\hbox{Te}}_{5}$ alloy is presented. Memory cells are bipolar selected, and are based on a $\mu{\hbox{trench}}$ architecture. Experimental investigation on multi-level cell (MLC) storage is addressed exploiting the chip MLC capability. To this end, a programming algorithm suitable for 2 bit/cell storage achieving tightly placed inner states (in terms of cell current or resistance) ...
Tópico(s): Semiconductor materials and devices
2009 - Institute of Electrical and Electronics Engineers | IEEE Journal of Solid-State Circuits
Giovanni Marzaro, Ilaria Lampronti, Elisabetta D’Aversa, Gianni Sacchetti, Giorgia Miolo, Christian Vaccarin, Giulio Cabrini, Maria Cristina Dechecchi, Roberto Gambari, Adriana Chilin,
A series of trimethylangelicin (TMA) derivatives were designed and synthesized to overcome the unwanted effects of TMA, promising agent for treatment of inflammation-related diseases and other pathologies, such as cystic fibrosis. The new generation TMA analogues bore hindered substituents at the 4 position in order to minimize or avoid the photoreactions with DNA. Among them, the 4-isopropyl-6-ethyl derivative 23 exhibited TMA-like inhibitory activity on NF-κB/DNA interactions but it proved unable ...
Tópico(s): Plant Pathogenic Bacteria Studies
2018 - Elsevier BV | European Journal of Medicinal Chemistry
Stefano Isgrò, Marco Giani, Laura Antolini, Riccardo Giudici, Maria Grazia Valsecchi, Giacomo Bellani, Osvaldo Chiara, Gabriele Bassi, Nicola Latronico, Luca Cabrini, Roberto Fumagalli, Arturo Chieregato, Fabrizio Sammartano, Giuseppe Maria Sechi, Alberto Zoli, Andrea Pagliosa, Alessandra Palo, Oliviero Valoti, Michele Carlucci, Annalisa Benini, Giuseppe Foti,
Prehospital field triage often fails to accurately identify the need for emergent surgical or non-surgical procedures, resulting in inefficient resource utilization and increased costs. This study aimed to analyze prehospital factors associated with the need for emergent procedures (such as surgery or interventional angiography) within 6 h of hospital admission. Additionally, our goal was to develop a prehospital triage tool capable of estimating the likelihood of requiring an emergent procedure ...
Tópico(s): Trauma Management and Diagnosis
2023 - Multidisciplinary Digital Publishing Institute | Journal of Clinical Medicine
Produção Nacional
Revisado por pares
Shirley Boller, Cristian Soldi, Maria Consuelo Andrade Marques, Dos Santos, Daniela Almeida Cabrini, Moacir Geraldo Pizzolatti, Aleksander Roberto Zampronio, Michel Fleith Otuki,
The tea from the leaves of Baccharis illinita DC (Asteraceae family) is commonly used by the population as anti-inflammatory (including topically), protective gastric and anti-infectious. However, no studies have been done with this species to confirm its topical anti-inflammatory action. This study evaluated he topical effects of crude extract of leaves (CE) and its active constituents in 12-O-tetradecanoilforbol acetate (TPA)-induced ear oedema. CE and compounds effects were tested in commonly used ...
Tópico(s): Plant Toxicity and Pharmacological Properties
2010 - Elsevier BV | Journal of Ethnopharmacology