Jessica Gasparello, Elisabetta D’Aversa, Giulia Breveglieri, Monica Borgatti, Alessia Finotti, Roberto Gambari,
One of the major clinical features of COVID-19 is a hyperinflammatory state, which is characterized by high expression of cytokines (such as IL-6 and TNF-α), chemokines (such as IL-8) and growth factors and is associated with severe forms of COVID-19. For this reason, the control of the "cytokine storm" represents a key issue in the management of COVID-19 patients. In this study we report evidence that the release of key proteins of the COVID-19 "cytokine storm" can be inhibited by mimicking the biological ...
Tópico(s): Immune cells in cancer
2021 - Elsevier BV | International Immunopharmacology
Jessica Gasparello, Michela Lomazzi, Chiara Papi, Elisabetta D’Aversa, Francesco Sansone, Alessandro Casnati, Gaetano Donofrío, Roberto Gambari, Alessia Finotti,
MicroRNAs (miRNAs) are short non-coding RNA molecules acting as gene regulators by repressing translation or by inducing degradation of the target RNA transcripts. Altered expression of miRNAs may be involved in the pathogenesis of many severe human diseases, opening new avenues in the field of therapeutic strategies, i.e., miRNA targeting or miRNA mimicking. In this context, the efficient and non-toxic delivery of premiRNA and antimiRNA molecules might be of great interest. The aim of the present ...
Tópico(s): Advanced biosensing and bioanalysis techniques
2019 - Cell Press | Molecular Therapy — Nucleic Acids
Elisabetta D’Aversa, Giulia Breveglieri, Patrizia Pellegatti, Giovanni Guerra, Roberto Gambari, Monica Borgatti,
Fetal sex determination is useful for families at risk of X-linked disorders, such as Duchenne muscular dystrophy, adrenal hypoplasia, hemophilia. At first, this could be obtained through invasive procedures such as amniocentesis and chorionic villus sampling, having a 1% risk of miscarriage. Since the discovery of cell-free fetal DNA (cffDNA) in maternal plasma, noninvasive prenatal testing permits the early diagnosis of fetal sex through analysis of cffDNA. However, the low amount of cffDNA relative ...
Tópico(s): Renal and related cancers
2018 - BioMed Central | Molecular Medicine
Giulia Breveglieri, Salvatore Pacifico, Cristina Zuccato, Lucia Carmela Cosenza, Shaiq Sultan, Elisabetta D’Aversa, Roberto Gambari, Delia Preti, Claudio Trapella, Renzo Guerrini, Monica Borgatti,
The screening of chemical libraries based on cellular biosensors is a useful approach to identify new hits for novel therapeutic targets involved in rare genetic pathologies, such as β-thalassemia and sickle cell disease. In particular, pharmacologically mediated stimulation of human γ-globin gene expression, and increase of fetal hemoglobin (HbF) production, have been suggested as potential therapeutic strategies for these hemoglobinopathies. In this article, we screened a small chemical library, ...
Tópico(s): Iron Metabolism and Disorders
2020 - Multidisciplinary Digital Publishing Institute | International Journal of Molecular Sciences
Ilaria Lampronti, Maria Cristina Dechecchi, Alessandro Rimessi, Valentino Bezzerri, Elena Nicolis, Alessandra Guerrini, Massimo Tacchini, Anna Tamanini, Silvia Munari, Elisabetta D’Aversa, Alessandra Santangelo, Giuseppe Lippi, Gianni Sacchetti, Paolo Pinton, Roberto Gambari, Maddalena Agostini, Giulio Cabrini,
Extracts from Nigella arvensis L. seeds, which are widely used as anti-inflammatory remedies in traditional medicine of Northern Africa, were able to inhibit the expression of the pro-inflammatory neutrophil chemokine Interleukin (IL)-8 in Cystic Fibrosis (CF) bronchial epithelial IB3-1 cells exposed to the Gram-negative bacterium Pseudomonas aeruginosa. The chemical composition of the extracts led to the identification of three major components, β-sitosterol, stigmasterol and campesterol, which are ...
Tópico(s): Cholesterol and Lipid Metabolism
2017 - Frontiers Media | Frontiers in Pharmacology
Giulia Breveglieri, Elisabetta D’Aversa, Lucia Carmela Cosenza, Effrossyni Boutou, Angeliki Balassopoulou, Ersi Voskaridou, Roberto Gambari, Monica Borgatti,
Sickle Cell Disease (SCD) is a monogenic hereditary blood disorder caused by a single point mutation (β
Tópico(s): Prenatal Screening and Diagnostics
2019 - Elsevier BV | Sensors and Actuators B Chemical
Giulia Breveglieri, Anna Travan, Elisabetta D’Aversa, Lucia Carmela Cosenza, Patrizia Pellegatti, Giovanni Guerra, Roberto Gambari, Monica Borgatti,
The β-thalassemias are genetic disorder caused by more than 200 mutations in the β-globin gene, resulting in a total (β0) or partial (β+) deficit of the globin chain synthesis. The most frequent Mediterranean mutations for β-thalassemia are: β039, β+IVSI-110, β+IVSI-6 and β0IVSI-1. Several molecular techniques for the detection of point mutations have been developed based on the amplification of the DNA target by polymerase chain reaction (PCR), but they could be labor-intensive and technically demanding. ...
Tópico(s): Iron Metabolism and Disorders
2017 - Public Library of Science | PLoS ONE
Jessica Gasparello, Elisabetta D’Aversa, Chiara Papi, Laura Gambari, Brunella Grigolo, Monica Borgatti, Alessia Finotti, Roberto Gambari,
A key clinical feature of COVID-19 is a deep inflammatory state known as "cytokine storm" and characterized by high expression of several cytokines, chemokines and growth factors, including IL-6 and IL-8. A direct consequence of this inflammatory state in the lungs is the Acute Respiratory Distress Syndrome (ARDS), frequently observed in severe COVID-19 patients. The "cytokine storm" is associated with severe forms of COVID-19 and poor prognosis for COVID-19 patients. Sulforaphane (SFN), one of the ...
Tópico(s): Curcumin's Biomedical Applications
2021 - Elsevier BV | Phytomedicine
Giovanni Marzaro, Ilaria Lampronti, Elisabetta D’Aversa, Gianni Sacchetti, Giorgia Miolo, Christian Vaccarin, Giulio Cabrini, Maria Cristina Dechecchi, Roberto Gambari, Adriana Chilin,
A series of trimethylangelicin (TMA) derivatives were designed and synthesized to overcome the unwanted effects of TMA, promising agent for treatment of inflammation-related diseases and other pathologies, such as cystic fibrosis. The new generation TMA analogues bore hindered substituents at the 4 position in order to minimize or avoid the photoreactions with DNA. Among them, the 4-isopropyl-6-ethyl derivative 23 exhibited TMA-like inhibitory activity on NF-κB/DNA interactions but it proved unable ...
Tópico(s): Plant Pathogenic Bacteria Studies
2018 - Elsevier BV | European Journal of Medicinal Chemistry
Giulia Breveglieri, Elisabetta D’Aversa, Tiziana Eleonora Gallo, Patrizia Pellegatti, Giovanni Guerra, Lucia Carmela Cosenza, Alessia Finotti, Roberto Gambari, Monica Borgatti,
Optical biosensors based on Surface Plasmon Resonance (SPR), such as the Biacore™ X100, are widely used to study in real-time and in label-free mode bio-molecular interactions, including those allowing the identification of single point mutations responsible of genetic diseases, such as thalassemia and cystic fibrosis. The aim of this study was to verify whether the Biacore™ X100 can be proposed for the real-time detection of four mutations of the human β-globin gene causing β-thalassemia, a genetic ...
Tópico(s): Bacteriophages and microbial interactions
2018 - Elsevier BV | Sensors and Actuators B Chemical
Concetta Avitabile, Luca Domenico D’Andrea, Elisabetta D’Aversa, Roberta Milani, Roberto Gambari, Alessandra Romanelli,
New peptides derived from the natural antimicrobial temporin B were obtained. The design, antimicrobial activity, and characterization of the secondary structure of peptides in the presence of bacterial cells is described herein. TB_KKG6K (KKLLPIVKNLLKSLL) has been identified as the most active analogue against Gram-positive and -negative bacteria, compared with natural temporin B (LLPIVGNLLKSLL) and TB_KKG6A (KKLLPIVANLLKSLL). Acylation with hydrophobic moieties generally led to reduced activity; however, ...
Tópico(s): Biochemical and Structural Characterization
2018 - Wiley | ChemMedChem
Matteo Zurlo, Francesco Nicoli, Davide Proietto, Beatrice Dallan, Cristina Zuccato, Lucia Carmela Cosenza, Jessica Gasparello, Chiara Papi, Elisabetta D’Aversa, Monica Borgatti, Chiara Scapoli, Alessia Finotti, Roberto Gambari,
Inhibitors of the mammalian target of rapamycin (mTOR) have been proposed to improve vaccine responses, especially in the elderly. Accordingly, testing mTOR inhibitors (such as Sirolimus) and other geroprotective drugs might be considered a key strategy to improve overall health resilience of aged populations. In this respect, Sirolimus (also known as rapamycin) is of great interest, in consideration of the fact that it is extensively used in routine therapy and in clinical studies for the treatment ...
Tópico(s): SARS-CoV-2 and COVID-19 Research
2023 - Wiley | Journal of Cellular and Molecular Medicine
Veronica Tisato, Juliana Araujo Silva, Fabio Scarpellini, Roberta Capucci, Roberto Marci, Ines Gallo, Francesca Salvatori, Elisabetta D’Aversa, Paola Secchiero, Maria Luisa Serino, Giorgio Zauli, Ajay Vikram Singh, Donato Gemmati,
Abstract Spontaneous abortion is a pregnancy complication characterized by complex and multifactorial etiology. About 5% of childbearing women are globally affected by early pregnancy loss (EPL) and most of them experience recurrence (RPL). Epigenetic mechanisms and controlled inflammation are crucial for pregnancy maintenance and genetic predispositions may increase the risk affecting the maternal–fetal crosstalk. Combined analyses of global methylation, inflammation and inherited predispositions ...
Tópico(s): Pregnancy and preeclampsia studies
2024 - Nature Portfolio | Scientific Reports
Elisabetta D’Aversa, Giulia Breveglieri, Effrossyni Boutou, Angeliki Balassopoulou, Ersi Voskaridou, Patrizia Pellegatti, Giovanni Guerra, Chiara Scapoli, Roberto Gambari, Monica Borgatti,
Non-invasive prenatal testing (NIPT) is based on the detection and characterization of circulating cell-free fetal DNA (ccffDNA) in maternal plasma and aims to identify genetic abnormalities. At present, commercial NIPT kits can detect only aneuploidies, small deletions and insertions and some paternally inherited single-gene point mutations causing genetic diseases, but not maternally inherited ones. In this work, we have developed two NIPT assays, based on the innovative and sensitive droplet digital ...
Tópico(s): Fetal and Pediatric Neurological Disorders
2022 - Multidisciplinary Digital Publishing Institute | International Journal of Molecular Sciences
Tommaso Dionisi, Luisa Sestito, Claudia Tarli, Massimo Antonelli, Alberto Tosoni, Stefano D’Addio, Antonio Mirijello, Gabriele Vassallo, Lorenzo Leggio, Antonio Gasbarrini, Giovanni Addolorato, Valeria Abbate, Nicola Acampora, Fabiana Agostini, Maria Elena Ainora, Elena Amato, Gloria Andriollo, B.E. Annicchiarico, Gabriele Antonucci, Alessandro Armuzzi, Christian Barillaro, Fabiana Barone, Rocco Bellantone, Daniela Belella, Andrea Bellieni, Andrea Benicchi, Francesca Benvenuto, Filippo Berloco, Roberto Bernabei, Antonio Bianchi, Luigi M. Biasucci, Stefano Bibbò, Federico Biscetti, Nicola Bonadia, Alberto Borghetti, Giulia Bosco, Silvia Laura Bosello, Vincenzo Bove, Giulia Bramato, Vincenzo Brandi, Dario Bruno, Maria Chiara Bungaro, Alessandro Buonomo, Maria Livia Burzo, Angelo Calabrese, Andrea Cambieri, Giulia Cammá, Marcello Candelli, Gennaro Capalbo, Lorenzo Capaldi, Esmeralda Capristo, Luigi Carbone, Silvia Cardone, Angelo Carfì, Annamaria Carnicelli, Claudia Carnuccio, Cristiano Caruso, Francesco Antonio Casciaro, Lucio Catalano, Roberto Cauda, Andrea Leonardo Cecchini, Lucia Cerrito, Michele Ciaburri, Rossella Cianci, Sara Cicchinelli, Arturo Ciccullo Francesca Ciciarello, Antonella Cingolani, Maria Camilla Cipriani, Gaetano Coppola, Andrea Corsello, Federico Costante, Marcello Covino, A. D'Alessandro, Maria E. D'Alfonso, Emanuela D’Angelo, Marco D'Angelo, F. D’Aversa, Alessandro D’Errico, Fernando Damiano, Tommaso de Cunzo, Giuseppe De Matteis, Martina De Siena, Francesco Vito, Valeria Del Gatto, Paola Del Giacomo, Fabio Del Zompo, Davide Antonio Della Polla, Elisabetta Del Sordo, Luca Di Gialleonardo, Simona Di Giambenedetto, Roberta Di Luca, Luca Di Maurizio, Alex Dusina, Alessandra Esperide, Domenico Faliero, Cinzia Falsiroli, Massimo Fantoni, Annalaura Fedele, Daniela Feliciani, Daniele Ferrarese, Andrea Flex, Evelina Forte, Francesco Franceschi, Laura Franza, Barbara Funaro, Mariella Fuorlo, Domenico Fusco, Maurizio Gabrielli, Eleonora Gaetani, Antonella Gallo, Giovanni Gambassi, Matteo Garcovich, Irene Gasparrini, Silvia Gelli, Antonella Giampietro, Laura Gigante, Gabriele Giuliano, Giuliano Giorgia, Bianca Giupponi, Elisa Gremese, Caterina Guidone, Amerigo Iaconelli, Angela Iaquinta, Michele Impagnatiello, Riccardo Inchingolo, Raffaele Iorio, Immacolata Izzi, Cristina Kadhim, Daniele Ignazio La Milia, Francesco Landi, Giovanni Landi, Rosario Landi, Massimo Leo, Antonio Liguori, Rosa Liperoti, Marco Maria Lizzio, Maria Rita Lo Monaco, Pietro Locantore, Francesco Lombardi, Loris Riccardo Lopetuso, Valentina Loria, Angela Raffaella Losito, Noemi Macerola, G. Maiuro, Francesco Antonio Mancarella, Francesca Mangiola, A Manno, Sergio Mannucci, Debora Marchesini, Giuseppe Marrone, Ilaria Martis, Anna Maria Martone, Emanuele Marzetti, Maria Valeria Matteo, Luca Miele, Alessio Migneco, Irene Mignini, Alessandro Milani, Domenico Milardi, Massimo Montalto, Flavia Monti, Davide Moschese, Barbara P. L. Mothaenje, Celeste Ambra Murace, Rita Murri, Marco Napoli, Elisabetta Nardella, G. Natalello, Simone Navarra, Antonio Nesci, Maria Anna Nicolazzi, Alberto Nicoletti, Tommaso Nicoletti, R Nicolò, Nicola Nicolotti, Enrico Celestino Nista, Eugenia Nuzzo, Veronica Ojetti, Francesco Pagano, Cristina Pais, Maria Pallozzi, Alfredo Papa, Luigi Giovanni Papparella, Mattia Paratore, Giuseppe Parrinello, Giovanni Pecorini, Simone Perniola, Erika Pero, Claudia Petito, Luca Petricca, Martina Petrucci, Chiara Picarelli, Andrea Piccioni, Giulia Pignataro, R Pignataro, Marco Pizzoferrato, Fabrizio Pizzolante, Roberto Pola, Caterina Policola, Maurizio Pompili, Valerio Pontecorvi, Francesca Romana Ponziani, Valentina Popolla, Enrica Porceddu, Angelo Porfidia, Giuseppe Privitera, Daniela Pugliese, Gabriele Pulcini, S. Racco, Francesca Raffaelli, Gian Ludovico Rapaccini, Luca Richeldi, Emanuele Rinninella, Sara Rocchi, Stefano Romano, Federico Rosa, Laura Rossi, Rossi Raimondo, Enrica Rossini, Elisabetta Rota, Fabiana Rovedi, G Rumi, Andrea Russo, Luca Sabia, Andrea Salerno, Sara Salini, Lucia Salvatore, Samori Dehara, Maurizio Sanguinetti, Luca Santarelli, Paolo Santini, Angelo Santoliquido, Francesco Santopaolo, Michele Santoro, Francesco Sardeo, Caterina Sarnari, Luisa Saviano, Tommaso Schepis, Francesca Schiavello, Giancarlo Scoppettuolo, Carlo Romano Settanni, Valentina Siciliano, Benedetta Simeoni, Andrea Smargiassi, Domenico Staiti, Leonardo Stella, Eleonora Taddei, Talerico Rossella, Enrica Tamburrini, Pietro Tilli, Enrico Torelli, Matteo Tosato, Luca Tricoli, Marcello Tritto, Mario Tumbarello, Anita Maria Tummolo, Federico Valletta, G. Ventura, Lucrezia Verardi, Lorenzo Maria Vetrone, Giuseppe Vetrugno, Elena Visconti, Raffaella Zaccaria, Lorenzo Zelano, Lorenzo Zileri Dal Verme, Giuseppe Zuccalà,
Background and aims The COVID-19 pandemic represents a source of stress and potential burnout for many physicians. This single-site survey aimed at assessing perceived stress and risk to develop burnout syndrome among physicians operating in COVID wards. Methods This longitudinal survey evaluated stress and burnout in 51 physicians operating in the COVID team of Gemelli Hospital, Italy. Participants were asked to complete the Maslach Burnout Inventory (MBI) and the Perceived Stress Questionnaire ...
Tópico(s): Stress and Burnout Research
2021 - Wiley | International Journal of Clinical Practice
Cristina Zuccato, Lucia Carmela Cosenza, Matteo Zurlo, Jessica Gasparello, Chiara Papi, Elisabetta D’Aversa, Giulia Breveglieri, Ilaria Lampronti, Alessia Finotti, Monica Borgatti, Chiara Scapoli, Alice Stievano, Monica Fortini, E. Ramazzotti, Nicola Marchetti, Marco Prosdocimi, Maria Rita Gamberini, Roberto Gambari,
Introduction: β-thalassemia is caused by autosomal mutations in the β-globin gene, which induce the absence or low-level synthesis of β-globin in erythroid cells. It is widely accepted that a high production of fetal hemoglobin (HbF) is beneficial for patients with β-thalassemia. Sirolimus, also known as rapamycin, is a lipophilic macrolide isolated from a strain of Streptomyces hygroscopicus that serves as a strong HbF inducer in vitro and in vivo. In this study, we report biochemical, molecular, ...
Tópico(s): Blood groups and transfusion
2022 - SAGE Publishing | Therapeutic Advances in Hematology
Francesca Salvatori, Mariangela Pappadà, Giulia Breveglieri, Elisabetta D’Aversa, Alessia Finotti, Ilaria Lampronti, Roberto Gambari, Monica Borgatti,
Nonsense mutations promote premature translational termination, introducing stop codons within the coding region of mRNAs and causing inherited diseases, including thalassemia. For instance, in β039 thalassemia the CAG (glutamine) codon is mutated to the UAG stop codon, leading to premature translation termination and to mRNA destabilization through the well described NMD (nonsense-mediated mRNA decay). In order to develop an approach facilitating translation and, therefore, protection from NMD, ribosomal ...
Tópico(s): RNA modifications and cancer
2018 - BioMed Central | BMC Biotechnology
Alessandra Aiello, Flavia Giannessi, Zulema Percario, Katia Fecchi, Claudia Arenaccio, Stefano Leone, Maria Carollo, Elisabetta D’Aversa, Laurence Chaperot, Roberto Gambari, Massimo Sargiacomo, Elisabetta Affabris,
Plasmacytoid dendritic cells (pDCs) are a unique dendritic cell subset specialized in type I interferon production, whose role in Human Immunodeficiency Virus (HIV) infection and pathogenesis is complex and not yet well defined. Considering the crucial role of the accessory protein Nef in HIV pathogenicity, possible alterations in intracellular signalling and extracellular vesicle (EV) release induced by exogenous Nef on uninfected pDCs have been investigated. As an experimental model system, a human ...
Tópico(s): Immunotherapy and Immune Responses
2021 - Multidisciplinary Digital Publishing Institute | Viruses
Giulia Breveglieri, Lucia Carmela Cosenza, Patrizia Pellegatti, Giovanni Guerra, Francesca Salvatori, Elisabetta D’Aversa, Alessia Finotti, Roberto Gambari, Monica Borgatti,
Tópico(s): Animal Genetics and Reproduction
2016 - Spandidos Publishing | International Journal of Molecular Medicine
Veronica Ojetti, Angela Saviano, Marcello Covino, Nicola Acampora, Eliana Troiani, Francesco Franceschi, Abbate Valeria, Nicola Acampora, Giovanni Addolorato, Agostini Fabiana, Maria Elena Ainora, Akacha Karim, Elena Amato, Francesca Andreani, Gloria Andriollo, Maria Giuseppina Annetta, B.E. Annicchiarico, Massimo Antonelli, Gabriele Antonucci, Gian Marco Anzellotti, Alessandro Armuzzi, Baldi Fabiana, Barattucci Ilaria, Christian Barillaro, Fabiana Barone, Rocco Bellantone, Andrea Bellieni, Giuseppe Bello, Andrea Benicchi, Francesca Benvenuto, Berardini Ludovica, Filippo Berloco, Roberto Bernabei, Bianchi Antonio, Daniele Guerino Biasucci, Luigi M. Biasucci, Stefano Bibbò, Bini Alessandra, Alessandra Bisanti, Federico Biscetti, Maria Grazia Bocci, Nicola Bonadia, Filippo Bongiovanni, Alberto Borghetti, Bosco Giulia, Silvia Laura Bosello, Vincenzo Bove, Giulia Bramato, Vincenzo Brandi, Teresa Bruni, Carmine Bruno, Dario Bruno, Maria Chiara Bungaro, Alessandro Buonomo, Burzo Livia, Calabrese Angelo, Maria Rosaria Calvello, Andrea Cambieri, Cambise Chiara, Giulia Cammá, Marcello Candelli, Canistro Gennaro, Cantanale Antonello, Gennaro Capalbo, Lorenzo Capaldi, Emanuele Capone, Esmeralda Capristo, Luigi Carbone, Silvia Cardone, Simone Carelli, Angelo Carfì, Annamaria Carnicelli, Cristiano Caruso, Francesco Antonio Casciaro, Catalano Lucio, Roberto Cauda, Andrea Leonardo Cecchini, Lucia Cerrito, Melania Cesarano, Annalisa Chiarito, Rossella Cianci, Sara Cicchinelli, Ciccullo Arturo, Marta Cicetti, Francesca Ciciarello, Antonella Cingolani, Maria Camilla Cipriani, Maria Ludovica Consalvo, Gaetano Coppola, Giuseppe Maria Corbo, Andrea Corsello, Federico Costante, Costanzi Matteo, Marcello Covino, Crupi Davide, Salvatore Lucio Cutuli, D’Addio Stefano, A. D'Alessandro, Maria ElenaEmanuela D'AlfonsoD'Angelo, D’Aversa Francesca, Fernando Damiano, Gian Maria De Berardinis, Tommaso de Cunzo, Donati Katleen De Gaetano, Giulio De Luca, Giuseppe De Matteis, Gennaro De Pascale, Paolo De Santis, Martina De Siena, Francesco Vito, Valeria Del Gatto, Paola Del Giacomo, Fabio Del Zompo, Antonio Maria Dell’Anna, Davide Antonio Della Polla, Luca Di Gialleonardo, Simona Di Giambenedetto, Roberta Di Luca, Luca Di Maurizio, Mariangela Di Muro, Dusina Alex, Eleuteri Davide, Alessandra Esperide, Daniele Fachechi, Faliero Domenico, Falsiroli Cinzia, Massimo Fantoni, Annalaura Fedele, Feliciani Daniela, Ferrante Cristina, Giuliano Ferrone, R. Festa, Maria Fiore, Andrea Flex, Forte Evelina, Francesco Franceschi, Francesconi Alessandra, Laura Franza, Funaro Barbara, Mariella Fuorlo, Domenico Fusco, Maurizio Gabrielli, Eleonora Gaetani, Galletta Claudia, Antonella Gallo, Giovanni Gambassi, Garcovich Matteo, Antonio Gasbarrini, Gasparrini Irene, Gelli Silvia, Antonella Giampietro, Laura Gigante, Giuliano Gabriele, Giuliano Giorgia, Giupponi Bianca, Elisa Gremese, Domenico Luca Grieco, Manuel Guerrera, Valeria Guglielmi, Caterina Guidone, Antonio Gullì, Amerigo Iaconelli, Iafrati Aurora, Gianluca Ianiro, Angela Iaquinta, Michele Impagnatiello, Riccardo Inchingolo, Enrica Intini, Raffaele Iorio, Immacolata Izzi, Tamara Jovanović, Cristina Kadhim, Rosa La Macchia, Daniele Ignazio La Milia, Francesco Landi, Landi Giovanni, Rosario Landi, Raffaele Landolfi, Massimo Leo, Paolo Maria Leone, Laura Levantesi, Antonio Liguori, Rosa Liperoti, Marco Maria Lizzio, Maria Rita Lo Monaco, Pietro Locantore, Francesco Lombardi, Gianmarco Lombardi, Loris Riccardo Lopetuso, Loria Valentina, Angela Raffaella Losito, Mothanje Barbara Lucia, Francesco Macagno, Macerola Noemi, Maggi Giampaolo, G. Maiuro, Francesco Antonio Mancarella, Francesca Mangiola, Manno Alberto, Marchesini Debora, G Maresca, Marrone Giuseppe, Martis Ilaria, Anna Maria Martone, Emanuele Marzetti, Chiara Mattana, Maria Valeria Matteo, Riccardo Maviglia, Mazzarella Ada, Memoli Carmen, Luca Miele, Alessio Migneco, Irene Mignini, Milani Alessandro, Domenico Milardi, Montalto Massimo, Montemurro Giuliano, Flavia Monti, Luca Montini, Tony Christian Morena, Morra Vincenzina, Chiara Morretta, Davide Moschese, Celeste Ambra Murace, Martina Murdolo, Rita Murri, Marco Napoli, Elisabetta Nardella, G. Natalello, Daniele Natalini, Simone Navarra, Antonio Nesci, Nicoletti Alberto, Nicoletti Rocco, Tommaso Nicoletti, Nicolò Rebecca, Nicola Nicolotti, Enrico Celestino Nista, Eugenia Nuzzo, Oggiano Marco, Veronica Ojetti, Francesco Pagano, Gianfranco Paiano, Pais Cristina, Pallavicini Federico, Palombo Andrea, Paolillo Federico, Alfredo Papa, Papanice Domenico, Luigi Giovanni Papparella, Mattia Paratore, Giuseppe Parrinello, Giuliana Pasciuto, Pasculli Pierpaolo, Giovanni Pecorini, Simone Perniola, Erika Pero, Luca Petricca, Martina Petrucci, Picarelli Chiara, Piccioni Andrea, Piccolo Annalisa, Piervincenzi Edoardo, Giulia Pignataro, R Pignataro, Pintaudi Gabriele, Luca Pisapia, Pizzoferrato Marco, Pizzolante Fabrizio, Roberto Pola, Caterina Policola, Maurizio Pompili, Pontecorvi Flavia, Valerio Pontecorvi, Ponziani Francesca, Popolla Valentina, Porceddu Enrica, Angelo Porfidia, Lucia Maria Porro, Potenza Annalisa, Francesca Pozzana, Giuseppe Privitera, Daniela Pugliese, Gabriele Pulcini, Racco Simona, Francesca Raffaelli, Ramunno Vittoria, Gian Ludovico Rapaccini, Luca Richeldi, Emanuele Rinninella, Sara Rocchi, Bruno Romanò, Stefano Romano, Federico Rosa, Laura Rossi, Rossi Raimondo,
At the end of January 2020, the World Health Organization (WHO) declared the SARS-Cov-2 (or Coronavirus 19 [COVID-19]) infection a global health emergency [[1]Hsu L.Y. Chia P.Y. Lim J.F The novel coronavirus (SARS-CoV-2) epidemic.Ann Acad Med Singap. 2020; 49: 1-3Crossref Google Scholar]. The virus, belonging to the β-Coronaviruses, spreads mainly through the respiratory tract from person to person, using the transmembrane serine protease 2 (TMPRSS2) [[2]Matsuyama S. Nao N. Shirato K. Kawase M. Saito S. ...
Elsevier BV
Simona Di Giambenedetto, Arturo Ciccullo, Alberto Borghetti, Giovanni Gambassi, Francesco Landi, Elena Visconti, Lorenzo Zileri Dal Verme, Roberto Bernabei, Enrica Tamburrini, Roberto Cauda, Antonio Gasbarrini,
... Zileri Dal Verme, V. Abbate, S. Bibbò, F. D'Aversa, D. Feliciani, B. Funaro, M. Garcovich, M. Impagnatiello, ...
Tópico(s): Long-Term Effects of COVID-19
2020 - Wiley | Journal of Medical Virology
Liliana Elena Weimer, Loredana Falzano, Alessandra Mallano, Maria Giovanna Quaranta, Maurizio Massella, S. Rosato, P. Colombato, L. Giubilei, Alessia Ciancio, Andrea Iannone, Roberto Filomia, A. Orlandini, Salvatore Petta, F. Tamburrini, Pierluigi Blanc, F. D’Aversa, M.C. Pasetto, Elke Maria Erne, Donatella Ieluzzi, Silvia Storato, Marzia Margotti, M. Vinci, F.P. Russo, O. Patti, V. Rizzo, Adele Giammario, Ivan Gentile, Valentina Donati, Laura Staiano, Mario Masarone, Luisa Cavalletto, M. Gonzo, Francesca R. Giancotti, E Danieli, R Corsini, Maura Faraci, Luca Valenti, M Cappelletti, S. Camera, Susan Pellicano, B. Stagno, T. Tieghi, Michele Stanislaw Milella, Marcello Dallio, Alba Rocco, Marta Borghi, Davide Drenaggi, S. Zaltron, Giulia Morsica, L. Framarin, A. Capitano, Carlotta Cerva, Laura Ambra Nicolini, Loreta A. Kondili,
Tópico(s): Liver Disease and Transplantation
2015 - Elsevier BV | Digestive and Liver Disease
F. D’Aversa, Anna Baldan, Silvia Pecere, Roberto Agazzi, Antonio Gasbarrini, M. Colledan, P. Ravelli, S. Fagiuoli,
Backgrounds/aims De-novo autoimmune hepatitis (AIH) after liver transplantation (LT) is rising.Yet there is scarcity of data on the characteristics and the long-term outcomes of this condition.The aim of this study is to investigate the clinical characteristics and long-term outcomes of patients with de novo AIH following LT.Methods Using transplant liver biopsy database, we identified all patients with de-novo AIH following LT at our institution between 2008 and 2013.Patients with hepatitis C virus ...
Tópico(s): Pediatric Hepatobiliary Diseases and Treatments
2015 - Elsevier BV | Gastroenterology
Chiara Tupini, Adriana Chilin, Alice S. Rossi, Ida De Fino, Alessandra Bragonzi, Elisabetta D’Aversa, Lucia Carmela Cosenza, Christian Vaccarin, Gianni Sacchetti, Monica Borgatti, Anna Tamanini, Maria Cristina Dechecchi, Francesca Sanvito, Roberto Gambari, Giulio Cabrini, Ilaria Lampronti,
A series of new-generation TMA (4,6,4′-trimethyl angelicin) analogues was projected and synthetized in order to ameliorate anti-inflammatory activity, with reduced or absent toxicity. Since the NF-κB transcription factor (TF) plays a critical role in the expression of IL-8 (Interluekin 8), a typical marker of lung inflammation in Cystic Fibrosis (CF), the use of agents able to interfere with the NF-κB pathway represents an interesting therapeutic strategy. Through preliminary EMSA experiments, we identified ...
Tópico(s): Bacterial biofilms and quorum sensing
2022 - Multidisciplinary Digital Publishing Institute | International Journal of Molecular Sciences
Jessica Gasparello, Chiara Papi, Giulia Breveglieri, Elisabetta D’Aversa, Valentino Bezzerri, Giovanna D’Amico, Marco Cipolli, Roberto Gambari, Monica Borgatti, Alessia Finotti,
In the Shwachman-Diamond syndrome (SDS), mutations of the gene encoding for the SBDS protein causes several hematological disorders, including neutropenia and myelodysplastic syndrome (MDS), with high risk of acute myeloid leukemia (AML).MicroRNAs (miRNAs) are small noncoding RNAs regulating gene expression by sequence-selective targeting of mRNAs, leading to translational repression or mRNA degradation. Low miRNA expression is associated with the accumulation of target mRNAs; high miRNA content causes ...
Tópico(s): Pneumocystis jirovecii pneumonia detection and treatment
2019 - Elsevier BV | Blood
Valentino Bezzerri, Antonio Vella, Elisabetta D’Aversa, Martina Api, Marisole Allegri, Elena Marinelli Busilacchi, Giovanna D’Amico, Roberto Gambari, Claudio Sorio, Benedetta Fabrizzi, Vincenzo Bronte, Antonella Poloni, Monica Borgatti, Marco Cipolli,
Shwachman-Diamond syndrome (SDS) is one of the more common inherited bone marrow failure syndromes (IBMFS). Almost 90% of patients with SDS present mutations in the Shwachman-Bodian-Diamond syndrome gene (SBDS) which encodes for the homonymous small protein involved in ribogenesis. SDS is a multiple-organ disease mostly characterized by exocrine pancreas insufficiency, bone malformations, and more importantly bone marrow failure. Most patients with SDS present severe neutropenia, whereas thrombocytopenia ...
Tópico(s): RNA modifications and cancer
2019 - Elsevier BV | Blood
G Sabbioni, Elisabetta D’Aversa, Giulia Breveglieri, Michele Altieri, Christian Boni, Anna Pegoraro, Alessia Finotti, Roberto Gambari, Giovanna D’Amico, Antonio Vella, Giuseppe Lippi, Marco Cipolli, Valentino Bezzerri, Monica Borgatti,
Tópico(s): Pneumocystis jirovecii pneumonia detection and treatment
2025 - BioMed Central | Molecular Medicine
Maurizio Gabrielli, Giulia Pignataro, Marcello Candelli, Marta Sacco Fernandez, Martina Bizzarri, Alessandra Esperide, Francesco Franceschi, Abbate Valeria, Acampora Nicola, Addolorato Giovanni, Agostini Fabiana, Ainora Maria Elena, Akacha Karim, Elena Amato, Francesca Andreani, Gloria Andriollo, Maria Giuseppina Annetta, Annicchiarico Brigida Eleonora, Massimo Antonelli, Gabriele Antonucci, Anzellotti Gian Marco, Alessandro Armuzzi, Baldi Fabiana, Barattucci Ilaria, Christian Barillaro, Fabiana Barone, Bellantone Rocco Domenico Alfonso, Andrea Bellieni, Bello Giuseppe, Andrea Benicchi, Francesca Benvenuto, Berardini Ludovica, Filippo Berloco, Bernabei Roberto, Bianchi Antonio, Daniele Guerino Biasucci, Biasucci Luigi Marzio, Bibbò Stefano, Bini Alessandra, Alessandra Bisanti, Federico Biscetti, Maria Grazia Bocci, Nicola Bonadia, Filippo Bongiovanni, Alberto Borghetti, Bosco Giulia, Bosello Silvia, Vincenzo Bove, Giulia Bramato, Vincenzo Brandi, Bruni Teresa, Carmine Bruno, Dario Bruno, Bungaro Maria Chiara, Buonomo Alessandro, Burzo Livia, Calabrese Angelo, Calvello Maria Rosaria, Andrea Cambieri, Cambise Chiara, Giulia Cammá, Candelli Marcello, Canistro Gennaro, Cantanale Antonello, Capalbo Gennaro, Lorenzo Capaldi, Emanuele Capone, Capristo Esmeralda, Luigi Carbone, Silvia Cardone, Carelli Simone, Carfì Angelo, Annamaria Carnicelli, Cristiano Caruso, Casciaro Francesco Antonio, Catalano Lucio, Cauda Roberto, Cecchini Andrea Leonardo, Lucia Cerrito, Melania Cesarano, Annalisa Chiarito, Cianci Rossella, Marta Cicetti, Sara Cicchinelli, Ciccullo Arturo, Ciciarello Francesca, Antonella Cingolani, Cipriani Maria Camilla, Consalvo Maria Ludovica, Gaetano Coppola, Corbo Giuseppe Maria, Corsello Andrea, Federico Costante, Costanzi Matteo, Marcello Covino, Crupi Davide, Salvatore Lucio Cutuli, D’Addio Stefano, Alessia D’Alessandro, D’alfonso Maria Elena, D’Angelo Emanuela, D’Aversa Francesca, Fernando Damiano, Berardinis Gian De Maria, Cunzo De Tommaso, Gaetano Donati de Katleen, Luca De Giulio, Matteis De Giuseppe, Pascale De Gennaro, Santis De Paolo, Siena De Martina, Vito De Francesco, Gatto Del Valeria, Giacomo Del Paola, Zompo Del Fabio, Dell’Anna Antonio Maria, Polla Della Davide, Gialleonardo Di Luca, Giambenedetto Di Simona, Luca Di Roberta, Maurizio Di Luca, Muro Di Mariangela, Dusina Alex, Eleuteri Davide, Alessandra Esperide, Facheci Daniele, Faliero Domenico, Falsiroli Cinzia, Massimo Fantoni, Annalaura Fedele, Feliciani Daniela, Ferrante Cristina, Giuliano Ferrone, R. Festa, Fiore Maria Chiara, Flex Andrea, Forte Evelina, Francesco Franceschi, Francesconi Alessandra, Laura Franza, Funaro Barbara, Fuorlo Mariella, Fusco Domenico, Gabrielli Maurizio, Eleonora Gaetani, Galletta Claudia, Gallo Antonella, Gambassi Giovanni, Garcovich Matteo, Antonio Gasbarrini, Gasparrini Irene, Gelli Silvia, Giampietro Antonella, Gigante Laura, Giuliano Gabriele, Giuliano Giorgia, Giupponi Bianca, Elisa Gremese, Grieco Domenico Luca, Manuel Guerrera, Valeria Guglielmi, Caterina Guidone, Gullì Antonio, Amerigo Iaconelli, Iafrati Aurora, Gianluca Ianiro, Angela Iaquinta, Michele Impagnatiello, Riccardo Inchingolo, Enrica Intini, Iorio Raffaele, Izzi Immacolata Maria, Jovanovic Tamara, Cristina Kadhim, La Macchia Rosa, La Milia Daniele Ignazio, Francesco Landi, Landi Giovanni, Rosario Landi, Landolfi Raffaele, Massimo Leo, Leone Paolo Maria, Levantesi Laura, Antonio Liguori, Rosa Liperoti, Lizzio Marco Maria, Lo Monaco Maria Rita, Pietro Locantore, Francesco Lombardi, Gianmarco Lombardi, Lopetuso Loris, Loria Valentina, Losito Angela Raffaella, Lucia Mothanje Barbara Patricia, Macagno Francesco, Macerola Noemi, Maggi Giampaolo, Maiuro Giuseppe, Mancarella Francesco, Francesca Mangiola, Manno Alberto, Marchesini Debora, Maresca Gian Marco, Marrone Giuseppe, Martis Ilaria, Martone Anna Maria, Marzetti Emanuele, Chiara Mattana, Matteo Maria Valeria, Riccardo Maviglia, Mazzarella Ada, Memoli Carmen, Luca Miele, Alessio Migneco, Mignini Irene, Milani Alessandro, Domenico Milardi, Montalto Massimo, Montemurro Giuliano, Flavia Monti, Montini Luca, Morena Tony Christian, Morra Vincenzina, Davide Moschese, Murace Celeste Ambra, Martina Murdolo, Rita Murri, Marco Napoli, Nardella Elisabetta, G. Natalello, Daniele Natalini, Navarra Simone Maria, Antonio Nesci, Nicoletti Alberto, Nicoletti Rocco, Nicoletti Tommaso Filippo, Nicolò Rebecca, Nicoletti Rocco, Nicola Nicolotti, Nista Enrico Celestino, Eugenia Nuzzo, Oggiano Marco, Veronica Ojetti, Pagano Francesco Cosimo, Gianfranco Paiano, Pais Cristina, Paolillo Federico, Pallavicini Federico, Palombo Andrea, Alfredo Papa, Papanice Domenico, Papparella Luigi Giovanni, Mattia Paratore, Giuseppe Parrinello, Giuliana Pasciuto, Pasculli Pierpaolo, Giovanni Pecorini, Simone Perniola, Erika Pero, Luca Petricca, Martina Petrucci, Picarelli Chiara, Piccioni Andrea, Piccolo Annalisa, Piervincenzi Edoardo, Giulia Pignataro, R Pignataro, Pintaudi Gabriele, Luca Pisapia, Pizzoferrato Marco, Pizzolante Fabrizio, Roberto Pola, Caterina Policola, Maurizio Pompili, Pontecorvi Flavia, Valerio Pontecorvi, Ponziani Francesca, Popolla Valentina, Porceddu Enrica, Angelo Porfidia, Porro Lucia Maria, Potenza Annalisa, Francesca Pozzana, Giuseppe Privitera, Pugliese Daniela, Gabriele Pulcini, Racco Simona, Francesca Raffaelli, Ramunno Vittoria, Rapaccini Gian Ludovico, Richeldi Luca, Rinninella Emanuele, Sara Rocchi, Bruno Romanò, Stefano Romano, Federico Rosa,
Current literature suggests that the prevalence of asthma among COVID-19 patients is similar to global one and that asthma does not appear to increase the risk of developing severe COVID-19.[1][2][3][4][5][6][7][8] Published data come from studies on patients admitted to hospital for COVID-19, whereas little or no evidence are available on the setting of emergency department (ED).Aims of our study were to assess in consecutive adult patients admitted to emergency room for COVID-19:
Springer Science+Business Media
T.A. Di Rienzo, V. Cesario, M. Campanale, Maria Grazia D’Angelo, Federico Barbaro, F. D’Aversa, M. Siciliano, B.E. Annicchiarico, Maurizio Pompili, Antonio Grieco, G.L. Rapaccini, S. Akila Agnes, A.W. Avolio, Roberto Iezzi, Anna Maria De Gaetano, Giovanni Battista Gasbarrini, Antonio Gasbarrini, S.G. Hepatocatt,
of Digestive Diseases / Digestive and Liver Disease 46S (2014) S1-S144 S121 the follow-up (median 27.5 months, range 3-156) one case of tumor seeding along the needle tract (2.2%) occurred: the neoplastic implant was surgically removed and the patients died after 13 years following initial ablation.Local tumor progression was observed in 6 cases (12%).Conclusions: Direct puncture of subcapsular HCC nodules up to 4 cm with either RF cool-tip needles or MW antennas proved to be a safe and effective procedure. ...
Tópico(s): Gallbladder and Bile Duct Disorders
2014 - Elsevier BV | Digestive and Liver Disease
Teresa Antonella Di Rienzo, V. Cesario, Mariachiara Campanale, Giovanna D’Angelo, Federico Barbaro, F. D’Aversa, G. Caracciolo, B.E. Annicchiarico, Massimo Siciliano, A.W. Avolio, S. Agnes, Maurizio Pompili, Gian Ludovico Rapaccini, Antonio Grieco, Annamaria De Gaetano, Roberto Iezzi, Antonio Gasbarrini,
Partially Hydrolyzed Guar Gum (PHGG) Attenuates Nonalcoholic Steatohepatitis (NASH) in Mice Through the Gut-Liver Axis Kazuhiro Katada, Yuji Naito, Tomohisa Takagi, Katsura Mizushima, Yasuki Higashimura, Tetsuya Okayama, Naohisa Yoshida, Kazuhiro Kamada, Kazuhiko Uchiyama, Ishikawa Takeshi, Osamu Handa, Hideyuki Konishi, Nobuaki Yagi, Hiroshi Ichikawa, Zenta Yasukawa, Makoto Tokunaga, Tsutomu Okubo, Lekh R. Juneja, Yoshito Itoh
Tópico(s): Pancreatic function and diabetes
2014 - Elsevier BV | Gastroenterology