Soledad Vidaurre, Christopher J. Fitzpatrick, Verónica A. Burzio, Macarena Briones, Claudio Villota, Jaime Villegas, Javiera Echenique, Luciana Oliveira-Cruz, Mariela Araya, Vincenzo Borgna, Teresa Socı́as, Constanza López, Rodolfo Esteban Ávila, Luis O. Burzio,
Hallmarks of cancer are fundamental principles involved in cancer progression. We propose an additional generalized hallmark of malignant transformation corresponding to the differential expression of a family of mitochondrial ncRNAs (ncmtRNAs) that comprises sense and antisense members, all of which contain stem-loop structures. Normal proliferating cells express sense (SncmtRNA) and antisense (ASncmtRNA) transcripts. In contrast, the ASncmtRNAs are down-regulated in tumor cells regardless of tissue ...
Tópico(s): interferon and immune responses
2014 - Elsevier BV | Journal of Biological Chemistry
Vincenzo Borgna, Lorena Lobos‐González, Francisca Guevara, Eduardo Landerer, Maximiliano Bendek, Rodolfo Esteban Ávila, Verónica Silva, Claudio Villota, Mariela Araya, Alexis Rivas, Constanza López, Teresa Socı́as, Jorge Castillo, Luis Alarcón, Luis O. Burzio, Verónica A. Burzio, Jaime Villegas,
Knockdown of the antisense noncoding mitochondrial RNAs (ASncmtRNAs) induces apoptotic death of several human tumor cell lines, but not normal cells, supporting a selective therapy against different types of cancer.In this work, we evaluated the effects of knockdown of ASncmtRNAs on bladder cancer (BCa).We transfected the BCa cell lines UMUC-3, RT4 and T24 with the specific antisense oligonucleotide Andes-1537S, targeted to the human ASncmtRNAs.Knockdown induced a strong inhibition of cell proliferation ...
Tópico(s): RNA Research and Splicing
2020 - Ivyspring International Publisher | Journal of Cancer
Rodolfo Daniel Ávila‐Avilés, Nayely Torres-Gómez, M.A. Camacho-López, Alfredo R. Vilchis-Néstor,
Abstract Nature provides remarkable examples of mass-produced microscale particles with structures and chemistries optimized by evolution for particular functions. Synthetic chemical tailoring of such sustainable biogenic particles may be used to generate new multifunctional materials. Herein, we report a facile method for the synthesis of hybrid nano/microstructures Ag-Fe 3 O 4 based on Dimorphotheca ecklonis pollen grains as bio-template. Silver nanoparticles was biosynthesized using pollen grains ...
Tópico(s): Iron oxide chemistry and applications
2020 - Nature Portfolio | Scientific Reports
Rodolfo Gamaliel Avila‐Bonilla, Martha Yocupicio‐Monroy, Laurence A. Marchat, David Guillermo Pérez-Ishiwara, Doris Cerecedo, Rosa M. del Ángel, Juan Santiago Salas-Benito,
Dengue virus (DENV) is an important flavivirus that is transmitted to humans by Aedes mosquitoes, where it can establish a persistent infection underlying vertical and horizontal transmission. However, the exact mechanism of persistent DENV infection is not well understood. Recently miR-927 was found to be upregulated in C6/36-HT cells at 57 weeks of persistent infection (C6-L57), suggesting its participation during this type of infection. The aim of this study was to determine the role of miR-927 ...
Tópico(s): Viral Infections and Vectors
2020 - Microbiology Society | Journal of General Virology
Óscar Hernández‐Hernández, Rodolfo Daniel Ávila‐Avilés, J. Manuel Hernández‐Hernández,
Cellular commitment and differentiation involve the coordinated activation of specific sets of genes and the repression of others, through the cooperation of specialized molecular mechanisms. In addition to the activity of specific transcription factors and chromatin modifying enzymes, the three-dimensional organization of genes and their regulatory elements are recognized to play a crucial role in transcriptional regulation on multiple cellular contexts. Long-range interactions allow communication ...
Tópico(s): RNA modifications and cancer
2020 - Frontiers Media | Frontiers in Genetics
Rodolfo Gamaliel Avila‐Bonilla, Martha Yocupicio‐Monroy, Laurence A. Marchat, Mónica De Nova-Ocampo, Rosa M. del Ángel, Juan Santiago Salas-Benito,
Dengue virus (DENV) is the most important arbovirus in the world; DENV is transmitted by the Aedes genus of mosquitoes and can establish a life-long persistent infection in mosquitoes. However, the exact mechanism by which persistent infection is established remains unknown. In this study the differential expression of miRNAs was analysed by deep sequencing and RT-qPCR using a previously established C6/36-HT cell line persistently infected with DENV 2 (C6-L) as a model. miR-927, miR-87, miR-210, miR- ...
Tópico(s): Insect symbiosis and bacterial influences
2017 - Elsevier BV | Virus Research
Alexis Rivas, Verónica A. Burzio, Eduardo Landerer, Vincenzo Borgna, Sebastián Gatica, Rodolfo Esteban Ávila, Constanza López, Claudio Villota, Rodrigo de la Fuente, Javiera Echenique, Luis O. Burzio, Jaime Villegas,
Abstract Background Bladder cancer is a significant cause of morbidity and mortality with a high recurrence rate. Early detection of bladder cancer is essential in order to remove the tumor, to preserve the organ and to avoid metastasis. The aim of this study was to analyze the differential expression of mitochondrial non-coding RNAs (sense and antisense) in cells isolated from voided urine of patients with bladder cancer as a noninvasive diagnostic assay. Methods The differential expression of the ...
Tópico(s): RNA modifications and cancer
2012 - BioMed Central | BMC Urology
María Elena Samar, Rodolfo Esteban Ávila, Francisco J. Esteban, Luis Olmedo, Luis E. Dettin, Adriana Raquel Massone, Juan Ángel Pedrosa, María Ángeles Peinado,
Salivary glands are a good model to investigate the relationship between cell secretion and glandular structure. Most studies of this organ deal with mammals, but we are interested in a morphofunctional characterization of these glands in poultry in relation with particular feeding habits. For this purpose, conventional and lectin histochemical methods as well as ultrastructural methods have been applied to the chicken lateral and medial palatine salivary glands. It was found that periodic acid- ...
Tópico(s): Glycosylation and Glycoproteins Research
2002 - Elsevier BV | Acta Histochemica
María Elena Samar, Rodolfo Esteban Ávila, S P de Fabro, Veronica Porfirio, Francisco J. Esteban, Juan Ángel Pedrosa, María Ángeles Peinado,
The histological and histochemical features of the minor salivary glands during postnatal development have been generally associated with the type of food ingested. However, recent studies support the fact that these salivary glands develop independently of the diet; in fact, minor salivary glands have similar morphological and histochemical characteristics in adult individuals of species with different diet regimens. Thus, the aim of this study was to characterize the developmental morphology of ...
Tópico(s): Proteoglycans and glycosaminoglycans research
1999 - Wiley | The Anatomical Record
Harry N. Antoniades, M A Bravo, Rodolfo Esteban Ávila, T Galanopoulos, J Neville-Golden, Marius Maxwell, Moisés Selman,
Fibrosis is a complex process involving an inflammatory reaction, fibroblast proliferation, and abnormal accumulation of interstitial collagens. Mononuclear cells are usually present in lung fibrosis. Activated monocytes and macrophages in culture have been shown to produce several growth factors including platelet-derived growth factor (PDGF). PDGF is a potent mitogen and chemoattractant for fibroblasts and smooth muscle cells and a stimulator of collagen synthesis. We have studied the expression ...
Tópico(s): IL-33, ST2, and ILC Pathways
1990 - American Society for Clinical Investigation | Journal of Clinical Investigation
Estefanía Contreras-Sanzón, Carlos Palma‐Flores, Ali Flores‐Pérez, Yarely M. Salinas-Vera, Macrina B. Silva-Cázares, Laurence A. Marchat, Rodolfo Gamaliel Avila‐Bonilla, Olga N. Hernández-de la Cruz, María Elizbeth Álvarez-Sánchez, Carlos Pérez‐Plasencia, Alma D. Campos-Parra, César López‐Camarillo,
Vasculogenic mimicry (VM) is characterized by formation of three-dimensional (3D) channels-like structures by tumor cells, supplying the nutrients needed for tumor growth. VM is stimulated by hypoxic tumor microenvironment, and it has been associated with increased metastasis and clinical poor outcome in cancer patients. cAMP responsive element (CRE)-binding protein 5 (CREB5) is a hypoxia-activated transcription factor involved in tumorigenesis. However, CREB5 functions in VM and if its regulated by ...
Tópico(s): Circular RNAs in diseases
2022 - IOS Press | Cancer Biomarkers
Diego Camps, Yanina Recuero, María Elena Samar, Rodolfo Esteban Ávila,
Objective: The purpose of the foliowing study was to describe trends ¡ti the use of iriformation by dentistry thesists and their research topics in Medical Education. Ethics and History. Material and Methods: Of a total of 290 doctorate thesis of the Dentistry Faculty made from 1965 to 2002, were iclentified: 3 theses on Medical Education and 1 on Ethics. On these, bibliographic quotations from periodic and non periodic publications, as well as quotations froru doctorate thesis anci congrcss acts ...
Tópico(s): Psychology Research and Bibliometrics
2005 - National University of Córdoba | Revista de la Facultad de Ciencias Médicas de Córdoba
Matxalen Llosa, Kerman Aloria, Rafael Campo, Rodolfo Padilla, Jesús Ávila, Luis Sánchez‐Pulido, Juan Carlos Zabala,
p14 is a molecular chaperone involved in β‐tubulin folding which catalyzes the release of β‐tubulin monomers from intermediate complexes. Here we demostrate that active p14 protein which we have purified from an overproducing Escherichia coli strain can also release ‐tubulin monomers from tubulin dimers in the presence of an additional cofactor (Z). Analysis of p14 secondary structure suggests that this protein may belong to a family of conserved proteins which share structural similarities with the ...
Tópico(s): DNA Repair Mechanisms
1996 - Wiley | FEBS Letters
Produção Nacional
Revisado por pares
Bruno Rodolfo Schlemper, Cláudio Ávila, J. Rodrigues Coura, Z. Brener,
Mice were infected with blood forms of 17 Trypanosoma cruzi strains recently isolated from chronic patients, which were dassified as of low, medium or high virulence on grounds of the prepatent period, parasitemia and mortality at the acute phase. A total of 212 mice were studied after 3, 6, 9 and 12 months of infection. In the chronic phase, intracellular parasites were detected in 11.0%,27.9%and 54.0,% of mice inoculated, respectively, with the low, medium and high virulent strains (r= 0.98, p < ...
Tópico(s): Helminth infection and control
1983 - Brazilian Society of Tropical Medicine | Revista da Sociedade Brasileira de Medicina Tropical
Rodolfo Esteban Ávila, María Elena Samar, Kapil Sugand, David Metcalfe, Jessica Evans, Peter Abrahams,
Background: Biomedical teaching has been revolutionized through multimedia and global collaboration. In a joint effort between Argentina and the UK, a Virtual Laboratory has been created for teaching morphological topics interactively pertaining to cell biology, histology and embryology intended for Health Science students at the National University of Cordoba, Argentina. Aim: To observe whether the online resource has changed the attitudes of student-users and offers a suitable replacement to traditional ...
Tópico(s): Genetics, Bioinformatics, and Biomedical Research
2013 - Scientific Research Publishing | Creative Education
Aída Andrea Bozzo, Carlos Alberto Soñez, Ignacio Cobeta, Rodolfo Esteban Ávila, Alicia Nélida Rolando, María Cristina Romanini, Mario Lazarte, Héctor Fernando Gauna, María Teresa Mugnaini,
Chronic stress by immobilization during pregnancy may cause alterations in mechanisms maintaining homeostasis in the adrenal gland.The objective of this study was to quantify cellular proliferation index in the adrenal cortex during pregnancy second half and assess the effects of chronic stress on it.Adrenal cortex proliferation index in stressed rats showed a significant decrease at 12 and 17 days of gestation, while at day 21 it did not show differences with the control treatments.Moreover, proliferation ...
Tópico(s): Hormonal Regulation and Hypertension
2011 - Chilean Society of Anatomy | International Journal of Morphology
Rodolfo Daniel Ávila‐Avilés, Liliana Argueta‐Figueroa, René García‐Contreras, Alfredo R. Vilchis-Néstor,
Silver (Ag) and gold (Au) nanoparticles, have gained attention for their unique properties and diverse applications, including medicine and antimicrobial agents. To meet the demand for eco-friendly synthesis methods, we explored plant-mediated nanoparticle synthesis using Anemopsis californica extracts. The Anemopsis californica leaves were used to extract bioactive compounds with water, methanol, and isopropanol. These extracts served as reducing and stabilizing agents for Ag and Au nanoparticle ...
Tópico(s): Nanotechnology research and applications
2024 - Elsevier BV | Materials Today Communications
Rodolfo Gamaliel Avila‐Bonilla, Juan Santiago Salas-Benito,
The genus Flavivirus of the Flaviviridae family includes important viruses, such as Dengue, Zika, West Nile, Japanese encephalitis, Murray Valley encephalitis, tick-borne encephalitis, Yellow fever, Saint Louis encephalitis, and Usutu viruses. They are transmitted by mosquitoes or ticks, and they can infect humans, causing fever, encephalitis, or haemorrhagic fever. The treatment resources for these diseases and the number of vaccines available are limited. It has been discovered that eukaryotic ...
Tópico(s): interferon and immune responses
2022 - Frontiers Media | Frontiers in Cellular and Infection Microbiology
Rodolfo Daniel Ávila‐Avilés, M.A. Camacho-López, Ernestina Castro‐Longoria, Alejandro Dorazco‐González, Nadia Hernández-Guerrero, Alfredo R. Vilchis-Néstor,
Tópico(s): Laser-Ablation Synthesis of Nanoparticles
2020 - Springer Science+Business Media | MRS Advances
Nayely Torres-Gómez, Rodolfo Daniel Ávila‐Avilés, Alfredo R. Vilchis-Néstor,
Los métodos de obtención de nanoestructuras han sido un área de estudio fundamental desde el inicio del auge de la nanotecnología. La biosíntesis de nanoestructuras se inspira en los mecanismos que tienen algunos microorganismos y plantas para subsistir en ambientes con estrés químico. En el presente trabajo se presentan resultados novedosos que ha logrado nuestro grupo de investigación para generar nanoestructuras de Au y Ag con una morfología fácilmente sintonizable a partir de los extractos de ...
Tópico(s): Nanotechnology research and applications
2020 - National Autonomous University of Mexico | Mundo Nano Revista Interdisciplinaria en Nanociencia y Nanotecnología
Rodolfo Tuirán, José Luis Ávila,
This article estimates the volume of skilled migration from Mexico to the United States in the period 2000-2012, including those who, after living for a time in the neighboring country to the north, returned to Mexico in the latter half of the last decade; it outlines, for both types of migratory flows, their socio-demographic, employment and economic profiles.Taking into account the recent evolution and growing importance of this phenomenon, the article critically reviews the proposed principles ...
Tópico(s): Regional Socio-Economic Development Trends
2013 - | Migración y Desarrollo
Chao Wang, Berta Esteban Fernández de Ávila, Rodolfo Mundaca‐Uribe, Miguel Angel Lopez‐Ramirez, Doris E. Ramírez‐Herrera, Sourabh Shukla, Nicole F. Steinmetz, Joseph Wang,
Virus-like nanoparticles (VLPs) have been used as an attractive means in cancer immunotherapy because of their unique intrinsic immunostimulatory properties. However, for treating metastatic tumors in the peritoneal cavity, such as ovarian cancer, multiple injections of therapy are needed due to the large peritoneal space and fast excretion of therapy. Here, it is reported on the development of active VLP delivery vehicles for the treatment of peritoneal ovarian tumors using biocompatible Qβ VLPs- ...
Tópico(s): Microfluidic and Bio-sensing Technologies
2020 - Wiley | Small
Evelyn Hackl, Christine Hölzl, Cornelia Konlechner, Angela Sessitsch,
... communicable disease bulletin, 17, Castell Monsalve J, Gutiérrez Avila G, Rodolfo Saavedra R and Santos Azorín A, 2008. [Shigellosis ...
Tópico(s): Enterobacteriaceae and Cronobacter Research
2013 - European Food Safety Authority | EFSA Supporting Publications
Rodolfo Hernández‐Gutiérrez, Leticia Ávila‐González, Jaime Ortega‐López, Fernando Cruz-Talonia, Guillermo Gómez-Gutiérrez, Rossana Arroyo,
Trichomonosis, a chronic sexually transmitted disease, remains a public health problem affecting yearly over 170 million people worldwide. This disease is caused by Trichomonas vaginalis, a protozoan flagellate rich in cysteine proteinases (CPs). Although CPs are involved in trichomonal cytopathogenicity, only few of them have been defined as virulence factors. In this study, we characterize a T. vaginalis 39-kDa proteinase (CP39) found in vaginal secretions from patients with trichomonosis. The CP39 ...
Tópico(s): Syphilis Diagnosis and Treatment
2004 - Elsevier BV | Experimental Parasitology
Beatríz González, Heberto Suárez-Roca, Alfonso Bravo, Rodolfo Salas‐Auvert, Dinorah Ávila,
Consumption of Arrabidaea bilabiata fresh leaves produces a paraplegic syndrome in cattle. For isolation of the active principle, isopropanol and methanol extracts were prepared from the aerial parts of the plant; these were administered to Sprague-Dawley rats at doses of 0.5, 1, and 2 mg/kg, orally, to determine the presence of substances affecting spontaneous motor activity. The isopropanol extract produced significant increases of long-pause and short-pause movements (112 and 54%, respectively). ...
Tópico(s): Plant and fungal interactions
2000 - Taylor & Francis | Pharmaceutical Biology
Eldo A. Avila, Rodolfo G. Pereyra,
Laboratory experiments of graupel charging during ice crystal collisions reveal a charge sign dependence on temperature, liquid water concentration as well as the size distribution of the cloud droplets used for riming. The measurements were performed with an impact velocity of 8.5 m s −1 , the ambient temperature was varied in the range −5 to −30°C and the effective water content up to 4 g m −3 . Charge diagrams of the sign of the electric current on the graupel as a function of the ambient temperature ( ...
Tópico(s): Plant Water Relations and Carbon Dynamics
2000 - American Geophysical Union | Geophysical Research Letters
Eldo E. Ávila, Rodolfo G. Pereyra, Guillermo G. Aguirre Varela, Giorgio M. Caranti,
Abstract Experiments were conducted with a wind tunnel in a cold room, in order to investigate the influence of the cloud‐droplet spectrum on the charges transferred when individual ice spheres collided with a fixed artificial graupel pellet growing by riming. the experiments were carried out with ice spheres of about 100 μm in diameter, impact velocities around 4 m s −1 , temperatures between −10°C and −30°C and effective water contents representative of real clouds. Two different cloud‐droplet spectra ...
Tópico(s): Icing and De-icing Technologies
1999 - Wiley | Quarterly Journal of the Royal Meteorological Society
Diego Camps, Yanina Recuero, Rodolfo Estebán Ãvila, MarÃa Elena Samar,
Los indicadores bibliometricos valoran la calidad cientifica, la actividad cientifica y la influencia (impacto) tanto del trabajo como de las fuentes. El analisis de las citas que una publicacion recibe de otras posteriores o de las referencias que una publicacion hace de otras anteriores es uno de los indicadores mas utilizados en Bibliometria. Se analizaron 30 articulos, divididos en las areas de Casos clinicos (n=7), Articulos originales (n=3), Imagenes (n=1), Intercambios (n=1), Comunicacion (n=1) ...
Tópico(s): Health and Medical Research Impacts
2006 - Universidad de Manizales | Archivos de Medicina
Trenton K. Ruebush, Wilmer Marquiño, Jorge Zegarra, Daniel Neyra, Rodolfo Villaroel, Juan Carlos Avila, César Eduardo Ochoa Díaz, Enrique Beltrán,
The World Health Organization (WHO) has developed guidelines for in vivo antimalarial drug efficacy testing for Plasmodium falciparum and Plasmodium vivax in areas with low-to-moderate transmission, such as the Americas. These guidelines are used widely by ministries of health and national malaria control programs to assess the efficacy of their first-line and second-line drugs for the treatment of malaria and to provide the information necessary to update national malaria treatment policies. Following ...
Tópico(s): Hemoglobinopathies and Related Disorders
2003 - American Society of Tropical Medicine and Hygiene | American Journal of Tropical Medicine and Hygiene
Juan Carlos Avila, Rodolfo Villaroel, Wilmer Marquiño, Jorge Zegarra, René Mollinedo, Trenton K. Ruebush,
Summary We assessed the efficacy of mefloquine monotherapy and mefloquine–artesunate (MQ–AS) combination therapy for the treatment of Plasmodium falciparum malaria at four sites in the Bolivian Amazon region. Patients with uncomplicated P. falciparum infections between 5 and 60 years of age were randomly assigned to be treated with either MQ (15 mg/kg in a single oral dose) or MQ (15 mg/kg) plus AS (4 mg/kg daily for 3 days). A total of 143 patients were enrolled and followed for 28 days. None of the ...
Tópico(s): Trypanosoma species research and implications
2004 - Wiley | Tropical Medicine & International Health