... Augustin Santiago, Miguel de Morillas, Gaspar Sanchez, Francisco Ruiz Martinez, Augustin de Cañas, Jacinto de Mena, 27 ... da Odem de NS do Carmo, called Fr Rodrigo, came to Dandi, por lhe parecer que nos ...
0000 - Gale Group | SASII
Matthew H. Taylor, Stephen Leong, Ying Su, Cynthia B. Leary, Xiaoyan Li, Keisuke Kuida, Rodrigo Ruiz‐Soto, Todd M. Bauer,
... Su, Cynthia B Leary, Xiaoyan Li, Keisuke Kuida, Rodrigo Ruiz-Soto, Todd Bauer. Phase 1 study of DCC- ...
Tópico(s): Sarcoma Diagnosis and Treatment
2019 - American Association for Cancer Research | Molecular Cancer Therapeutics
... Augustin Santiago, Miguel de Morillas, Gaspar Sanchez, Francisco Ruiz Martinez, Augustin de Cañas, Jacinto de Mena, 27 ... da Odem de NS do Carmo, called Fr Rodrigo, came to Dandi, por lhe parecer que nos ...
0000 - Gale Group | SASII
Suzanne George, Michael C. Heinrich, Ping Chi, A.R. Abdul Razak, Margaret von Mehren, Michael S. Gordon, Kristen N. Ganjoo, Neeta Somaiah, Jonathan C. Trent, Jordi Rodón, Jennifer Moriatis Wolf, Rodrigo Ruiz‐Soto, O. Rosen, Filip Janků,
Background: DCC-2618, a kinase switch control inhibitor, broadly inhibits mutations in KIT exons 9, 11, 13, 14, 17 and 18. Based on clinical activity observed in heavily pretreated GIST pts in a Phase 1 study, DCC-2618 is being evaluated in a Phase 3 study, INVICTUS (NCT03353753), in ≥ 4th line pts. Given the breadth of inhibition of KIT mutations and favorable tolerability profile, the Phase 1 study included expansion cohorts to assess clinical benefit in 2nd and 3rd line GIST pts in advance of the ...
Tópico(s): Gastrointestinal disorders and treatments
2018 - Elsevier BV | Annals of Oncology
... Augustin Santiago, Miguel de Morillas, Gaspar Sanchez, Francisco Ruiz Martinez, Augustin de Cañas, Jacinto de Mena, 27 ... da Odem de NS do Carmo, called Fr Rodrigo, came to Dandi, por lhe parecer que nos ...
0000 - Gale Group | SASII
Javier Cejudo, Débora Rodrigo-Ruiz, María Luz López-Delgado, Lidia Losada,
The aim of this work is to extend the research on the relationships between emotional intelligence and various indicators of subjective well-being in adolescents, such as stress and social anxiety. The existence of differences in stress and social anxiety as a function of an emotional intelligence score is also analyzed. A total of 505 Spanish adolescents between the ages of 12 and 18 participated in the study. The results obtained support the existence of a positive relationship between trait emotional ...
Tópico(s): Psychological and Temporal Perspectives Research
2018 - Multidisciplinary Digital Publishing Institute | International Journal of Environmental Research and Public Health
... Augustin Santiago, Miguel de Morillas, Gaspar Sanchez, Francisco Ruiz Martinez, Augustin de Cañas, Jacinto de Mena, 27 ... da Odem de NS do Carmo, called Fr Rodrigo, came to Dandi, por lhe parecer que nos ...
0000 - Gale Group | SASII
Produção Nacional
Revisado por pares
Hudson Kagueyama Takano, Rubem Silvério de Oliveira, Jamil Constantin, Claudete Aparecida Mangolim, Maria de Fátima P. S. Machado, Maycon Rodrigo Ruiz Bevilaqua,
The first reports of glyphosate‐resistant (GR) sourgrass ( Digitaria insularis ) came from Paraguay (2005) and from South and Southeast Brazil, in Paraná (2008), and São Paulo state (2009). The hypothesis of this research is that the evolution of these resistant populations might have occurred independently. To test this hypothesis, a dose–response experiment was conducted in order to confirm resistance and inter simple sequence repeat markers subsequently were evaluated in five sourgrass populations from ...
Tópico(s): Pesticide and Herbicide Environmental Studies
2018 - Wiley | Weed Biology and Management
... Augustin Santiago, Miguel de Morillas, Gaspar Sanchez, Francisco Ruiz Martinez, Augustin de Cañas, Jacinto de Mena, 27 ... da Odem de NS do Carmo, called Fr Rodrigo, came to Dandi, por lhe parecer que nos ...
0000 - Gale Group | SASII
Kathleen N. Moore, Hossein Borghaei, David M. O’Malley, Woondong Jeong, Shelly Seward, Todd M. Bauer, Raymond P. Perez, Ursula A. Matulonis, Kelli L. Running, Xiaoyan Zhang, Jose F. Ponte, Rodrigo Ruiz‐Soto, Michael J. Birrer,
BACKGROUND Mirvetuximab soravtansine (IMGN853) is an antibody‐drug conjugate that selectively targets folate receptor α (FRα). In this phase 1 dose‐escalation study, the authors investigated IMGN853 in patients with FRα‐positive solid tumors. METHODS Patients received IMGN853 on day 1 of a 21‐day cycle (once every 3 weeks dosing), with cycles repeated until patients experienced dose‐limiting toxicity or progression. Dose escalation commenced in single‐patient cohorts for the first 4 planned dose levels ...
Tópico(s): Lymphoma Diagnosis and Treatment
2017 - Wiley | Cancer
... Augustin Santiago, Miguel de Morillas, Gaspar Sanchez, Francisco Ruiz Martinez, Augustin de Cañas, Jacinto de Mena, 27 ... da Odem de NS do Carmo, called Fr Rodrigo, came to Dandi, por lhe parecer que nos ...
0000 - Gale Group | SASII
Lainie P. Martin, Jason Konner, Kathleen N. Moore, Shelly Seward, Ursula A. Matulonis, Raymond P. Perez, Ying Su, Anna Berkenblit, Rodrigo Ruiz-Soto, Michael J. Birrer,
To characterize folate receptor alpha (FRα) expression in archival and fresh biopsy tumor samples from relapsed ovarian cancer patients.
Tópico(s): Lymphoma Diagnosis and Treatment
2017 - Elsevier BV | Gynecologic Oncology
... Augustin Santiago, Miguel de Morillas, Gaspar Sanchez, Francisco Ruiz Martinez, Augustin de Cañas, Jacinto de Mena, 27 ... da Odem de NS do Carmo, called Fr Rodrigo, came to Dandi, por lhe parecer que nos ...
0000 - Gale Group | SASII
Produção Nacional
Revisado por pares
Kathleen N. Moore, Lainie P. Martin, David M. O’Malley, Ursula A. Matulonis, Jason Konner, Raymond P. Perez, Todd M. Bauer, Rodrigo Ruiz‐Soto, Michael J. Birrer,
Purpose This phase I expansion cohort study evaluated the safety and clinical activity of mirvetuximab soravtansine (IMGN853), an antibody-drug conjugate consisting of a humanized anti-folate receptor alpha (FRα) monoclonal antibody linked to the tubulin-disrupting maytansinoid DM4, in a population of patients with FRα-positive and platinum-resistant ovarian cancer. Patients and Methods Patients with platinum-resistant epithelial ovarian, fallopian tube, or primary peritoneal cancer received IMGN853 ...
Tópico(s): Intraperitoneal and Appendiceal Malignancies
2017 - Lippincott Williams & Wilkins | Journal of Clinical Oncology
... Augustin Santiago, Miguel de Morillas, Gaspar Sanchez, Francisco Ruiz Martinez, Augustin de Cañas, Jacinto de Mena, 27 ... da Odem de NS do Carmo, called Fr Rodrigo, came to Dandi, por lhe parecer que nos ...
0000 - Gale Group | SASII
Michael C. Heinrich, Robin L. Jones, Suzanne George, Hans Gelderblom, Patrick Schöffski, Margaret von Mehren, John Zalcberg, Yoon‐Koo Kang, Albiruni Abdul Razak, Jonathan C. Trent, Steven Attia, Axel Le Cesne, Brittany L. Siontis, David Goldstein, Kjetil Boye, César Sánchez, Neeltje Steeghs, Piotr Rutkowski, Mihaela Druta, César Serrano, Neeta Somaiah, Ping Chi, William M. Reichmann, Kam Sprott, Haroun Achour, Matthew L. Sherman, Rodrigo Ruiz‐Soto, Jean‐Yves Blay, Sebastian Bauer,
Abstract INTRIGUE was an open-label, phase 3 study in adult patients with advanced gastrointestinal stromal tumor who had disease progression on or intolerance to imatinib and who were randomized to once-daily ripretinib 150 mg or sunitinib 50 mg. In the primary analysis, progression-free survival (PFS) with ripretinib was not superior to sunitinib. In clinical and nonclinical studies, ripretinib and sunitinib have demonstrated differential activity based on the exon location of KIT mutations. Therefore, ...
Tópico(s): Gastric Cancer Management and Outcomes
2024 - Nature Portfolio | Nature Medicine
... Augustin Santiago, Miguel de Morillas, Gaspar Sanchez, Francisco Ruiz Martinez, Augustin de Cañas, Jacinto de Mena, 27 ... da Odem de NS do Carmo, called Fr Rodrigo, came to Dandi, por lhe parecer que nos ...
0000 - Gale Group | SASII
Hans Gelderblom, Vivek A. Bhadri, Silvia Stacchiotti, Sebastian Bauer, Andrew J. Wagner, Michiel A. J. van de Sande, Nicholas M. Bernthal, Antonio López‐Pousa, Albiruni Abdul Razak, Antoîne Italiano, Mahbubl Ahmed, Axel Le Cesne, Gabriel Tinoco, Kjetil Boye, Javier Martín‐Broto, Emanuela Palmerini, Salvatore Tafuto, Sarah Pratap, Benjamin Powers, Peter Reichardt, Antonio Casado, Piotr Rutkowski, Christopher Tait, Fiona Zarins, B. Harrow, Maitreyi G. Sharma, Rodrigo Ruiz‐Soto, Matthew L. Sherman, Jean‐Yves Blay, William D. Tap, Herbert H. Loong, Antonella Brunello, Andreas H. Krieg, Mark Algulnik, Richard F. Riedel, Scott H. Okuno, Elizabeth T. Loggers, Thierry Alcindor, Virginia Ferraresi, César Serrano, R. Lor Randall, Breelyn A. Wilky, Vinod Ravi,
Background Tenosynovial giant cell tumour (TGCT) is a locally aggressive neoplasm for which few systemic treatment options exist. This study evaluated the efficacy and safety of vimseltinib, an oral, switch-control, CSF1R inhibitor, in patients with symptomatic TGCT not amenable to surgery. Methods MOTION is a multicentre, randomised, double-blind, placebo-controlled, phase 3 trial done in 35 specialised hospitals in 13 countries. Eligible patients were adults (aged ≥18 years) with a histologically ...
Tópico(s): Elbow and Forearm Trauma Treatment
2024 - Elsevier BV | The Lancet
... Augustin Santiago, Miguel de Morillas, Gaspar Sanchez, Francisco Ruiz Martinez, Augustin de Cañas, Jacinto de Mena, 27 ... da Odem de NS do Carmo, called Fr Rodrigo, came to Dandi, por lhe parecer que nos ...
0000 - Gale Group | SASII
Michael C. Heinrich, Robin L. Jones, Hans Gelderblom, Suzanne George, Patrick Schöffski, Margaret von Mehren, John Zalcberg, Yoon‐Koo Kang, Albiruni Ryan Abdul Razak, Jonathan C. Trent, Steven Attia, Axel Le Cesne, Ying Su, Julie Nicole Meade, Tao Wang, Matthew L. Sherman, Rodrigo Ruiz‐Soto, Jean‐Yves Blay, Sebastian Bauer,
359881 Background: Sunitinib is approved for advanced gastrointestinal stromal tumor (GIST) after imatinib failure. Ripretinib, a broad-spectrum KIT and PDGFRA switch-control tyrosine kinase inhibitor (TKI), is indicated for the treatment of adult patients (pts) with GIST who received prior treatment with 3 or more TKIs, including imatinib. We compared the efficacy and safety of ripretinib vs sunitinib in pts with advanced GIST who progressed on or were intolerant to imatinib. Methods: This multicenter, ...
Tópico(s): Gastric Cancer Management and Outcomes
2022 - Lippincott Williams & Wilkins | Journal of Clinical Oncology
... Augustin Santiago, Miguel de Morillas, Gaspar Sanchez, Francisco Ruiz Martinez, Augustin de Cañas, Jacinto de Mena, 27 ... da Odem de NS do Carmo, called Fr Rodrigo, came to Dandi, por lhe parecer que nos ...
0000 - Gale Group | SASII
Sebastian Bauer, Robin L. Jones, Jean‐Yves Blay, Hans Gelderblom, Suzanne George, Patrick Schöffski, Margaret von Mehren, John Zalcberg, Yoon‐Koo Kang, Albiruni Abdul Razak, Jonathan C. Trent, Steven Attia, Axel Le Cesne, Ying Su, Julie Meade, Tao Wang, Matthew L. Sherman, Rodrigo Ruiz‐Soto, Michael C. Heinrich,
PURPOSE Sunitinib, a multitargeted tyrosine kinase inhibitor (TKI), is approved for advanced gastrointestinal stromal tumor (GIST) after imatinib failure. Ripretinib is a switch-control TKI approved for advanced GIST after prior treatment with three or more TKIs, including imatinib. We compared efficacy and safety of ripretinib versus sunitinib in patients with advanced GIST who were previously treated with imatinib (INTRIGUE, ClinicalTrials.gov identifier: NCT03673501 ). PATIENTS AND METHODS Random assignment ...
Tópico(s): Gastrointestinal disorders and treatments
2022 - Lippincott Williams & Wilkins | Journal of Clinical Oncology
... Augustin Santiago, Miguel de Morillas, Gaspar Sanchez, Francisco Ruiz Martinez, Augustin de Cañas, Jacinto de Mena, 27 ... da Odem de NS do Carmo, called Fr Rodrigo, came to Dandi, por lhe parecer que nos ...
0000 - Gale Group | SASII
Sebastian Bauer, Michael C. Heinrich, Suzanne George, John Zalcberg, César Serrano, Hans Gelderblom, Robin L. Jones, Steven Attia, Gina Z. D’Amato, Ping Chi, Peter Reichardt, Julie Meade, Ying Su, Rodrigo Ruiz‐Soto, Jean‐Yves Blay, Margaret von Mehren, Patrick Schöffski,
Abstract Purpose: Most patients with gastrointestinal stromal tumor (GIST) have activating mutations in KIT/PDGFRA and are initially responsive to tyrosine kinase inhibitors (TKI). The acquisition of secondary mutations leads to refractory/relapsed disease. This study reports the results of an analysis from the phase III INVICTUS study (NCT03353753) characterizing the genomic heterogeneity of tumors from patients with advanced GIST and evaluating ripretinib efficacy across KIT/PDGFRA mutation subgroups. ...
Tópico(s): Gastrointestinal disorders and treatments
2021 - American Association for Cancer Research | Clinical Cancer Research
... Augustin Santiago, Miguel de Morillas, Gaspar Sanchez, Francisco Ruiz Martinez, Augustin de Cañas, Jacinto de Mena, 27 ... da Odem de NS do Carmo, called Fr Rodrigo, came to Dandi, por lhe parecer que nos ...
0000 - Gale Group | SASII
Bryan D. Smith, Michael D. Kaufman, Scott Wise, Yu Mi Ahn, Timothy M. Caldwell, Cynthia B. Leary, Wei-Ping Lu, Gege Tan, Lakshminarayana Vogeti, Subha Vogeti, Breelyn A. Wilky, Lara E. Davis, Maitreyi G. Sharma, Rodrigo Ruiz‐Soto, Daniel L. Flynn,
Abstract Macrophages can be co-opted to contribute to neoplastic, neurologic, and inflammatory diseases. Colony-stimulating factor 1 receptor (CSF1R)-dependent macrophages and other inflammatory cells can suppress the adaptive immune system in cancer and contribute to angiogenesis, tumor growth, and metastasis. CSF1R-expressing osteoclasts mediate bone degradation in osteolytic cancers and cancers that metastasize to bone. In the rare disease tenosynovial giant cell tumor (TGCT), aberrant CSF1 expression ...
Tópico(s): Tendon Structure and Treatment
2021 - American Association for Cancer Research | Molecular Cancer Therapeutics
... Augustin Santiago, Miguel de Morillas, Gaspar Sanchez, Francisco Ruiz Martinez, Augustin de Cañas, Jacinto de Mena, 27 ... da Odem de NS do Carmo, called Fr Rodrigo, came to Dandi, por lhe parecer que nos ...
0000 - Gale Group | SASII
John Zalcberg, Michael C. Heinrich, Suzanne George, Sebastian Bauer, Patrick Schöffski, César Serrano, Hans Gelderblom, Robin L. Jones, Steven Attia, Gina Z. D’Amato, Ping Chi, Peter Reichardt, Neeta Somaiah, Julie Meade, V. Reichert, Kelvin Shi, Matthew L. Sherman, Rodrigo Ruiz‐Soto, Margaret von Mehren, Jean‐Yves Blay,
Abstract Background Ripretinib 150 mg once daily (QD) is indicated for advanced gastrointestinal stromal tumors (GISTs) as at least fourth-line therapy. In INVICTUS, ripretinib intrapatient dose escalation (IPDE) to 150 mg b.i.d. was allowed after progressive disease (PD) on 150 mg QD by blinded independent central review using modified RECIST 1.1. We report the efficacy and safety of ripretinib IPDE to 150 mg b.i.d. after PD among patients randomized to ripretinib 150 mg QD in the INVICTUS study. Materials ...
Tópico(s): Sarcoma Diagnosis and Treatment
2021 - AlphaMed Press | The Oncologist
... Augustin Santiago, Miguel de Morillas, Gaspar Sanchez, Francisco Ruiz Martinez, Augustin de Cañas, Jacinto de Mena, 27 ... da Odem de NS do Carmo, called Fr Rodrigo, came to Dandi, por lhe parecer que nos ...
0000 - Gale Group | SASII
Hernán Mauricio Romero, Edison Daza, Iván Ayala-Díaz, Rodrigo Ruiz-Romero,
Interspecific OxG hybrids of African palm Elaeis guineensis Jacq. and the American palm Elaeis oleifera Cortes produce high-oleic palm oil (HOPO) with low saturated fatty acid content. OxG hybrids are highly productive, grow slowly, and are resistant to bud rot disease. However, OxG hybrid pollen presents low viability and germinability, so assisted pollination is a must. Hybrids can produce parthenocarpic or seedless fruits, with the exogenous application of plant growth regulators. Thus, naphthalene ...
Tópico(s): Biodiesel Production and Applications
2021 - Multidisciplinary Digital Publishing Institute | Agronomy