
Ana Paula Mendes Carvalho, Angélica da Conceição Oliveira Coelho Fabri, Rodrigo Corrêa‐Oliveira, Francisco Carlos Félix Lana,
The diagnosis of leprosy is based on clinical symptoms of the disease, which may not be sufficient to ensure early diagnosis. The development of effective tools for the early detection of infection, such as rapid tests that can be applied by non-specialists for early-stage leprosy identification, has been considered a research priority and may contribute to overcoming the complications associated with late diagnosis. The aim of this study was to analyze the factors associated with anti-phenolic ...
Tópico(s): Mycobacterium research and diagnosis
2015 - BioMed Central | BMC Infectious Diseases

Muiara Aparecida Moraes, Celeida Silva Santos Bruna, Luiz Fabri Rodrigo, Scio Elita, Maria Silvana Alves, Hitomi Yamamoto Célia, Pereira Rodarte Mírian, Del-Vechio-Vieira Glauciemar, Lucía Ana, da Luz André de Araújo Aílson, Vieira de Sousa Orlando,
Palicourea rigida Kunth (Rubiaceae), also called "bate-caixa" or "douradão", has been used as antihypertensive, antiulcerogenic, anti-inflammatory and analgesic by traditional communities. Pharmacological potential of the ethanol extract from P. rigida (EEPR) and two quercetin derivatives were investigated. Using the high performance liquid chromatography (HPLC) assay, EEPR was analyzed. Phenolic contents (total phenolic and flavonoids) were quantified by spectrophotometric methods. 2,2-diphenyl-1-pycrilhydrazil ( ...
Tópico(s): Phytochemicals and Antioxidant Activities
2017 - Academic Journals | Journal of Medicinal Plants Research
Leonardo Torquetti, Rodrigo Fabri Berbel, Paulo Ferrara,
To report the long-term follow-up of Ferrara intrastromal corneal ring segment (ICRS) implantation for the management of keratoconus.Private clinic, Belo Horizonte, Brazil.This study comprised patients with keratoconus who completed at least 5 years of follow-up. One or 2 ICRS were inserted in the cornea, embracing the keratoconus area. Statistical analysis included preoperative and postoperative uncorrected distance visual acuity (UDVA), corrected distance visual acuity (CDVA), and keratometry (K) ...
Tópico(s): Corneal Surgery and Treatments
2009 - Lippincott Williams & Wilkins | Journal of Cataract & Refractive Surgery

Ana Paula Miyagusko Taba Oguido, Antônio Casella, Tiemi Matsuo, Eduardo Henrique de Freitas Ramos Filho, Rodrigo Fabri Berbel, Ricardo Montanheiro Alcântara Silva,
To determine the prevalence of early and late-stage age-related macular degeneration (ARMD) and its association with risk factors such as age, gender, smoking, body mass index, hypertension and diabetes history, cataracts and pseudophakia.Population-based cross-sectional study in an elderly Japanese-Brazilian population from Londrina (Paraná, Brazil).The study included 483 (80.5%) of the 600 registered members of a local association for Japanese immigrants and their descendants, aged 60 years and up. ...
Tópico(s): Glaucoma and retinal disorders
2008 - Conselho Brasileiro de Oftalmologia | Arquivos Brasileiros de Oftalmologia

Silvia Franco Andrade, Daniel Silva Kupper, Luiz Fernando Rodrigues de Pinho, Elizabeth Franco, Marcus Vinícius Felix Fabri Prataviera, Rodrigo Rolim Duarte, José Ricardo Cecílio Junqueira,
The objective of this study was to evaluate and validate the accuracy of the Perkins handheld applanation tonometer for measuring intraocular pressure (IOP) in horses and cattle. Both eyes of 10 adult horses and cattle were evaluated in a postmortem study. The eyes from 10 clinically normal adult horses and cattle were also examined after bilateral auriculopalpebral nerve block and topical anesthesia for an in vivo study. IOP was measured postmortem using direct manometry (measured with an aneroid ...
Tópico(s): Ocular Surface and Contact Lens
2011 - Korean Society of Veterinary Science | Journal of Veterinary Science

Antônio Casella, Rodrigo Fabri Berbel, Gláucio Luciano Bressanim, Marcus Rudolph Malaguido, J.A. Cardillo,
OBJECTIVES:The objective of this study was to evaluate the relationship between the treatment of Helicobacter pylori gastric infection and changes in best-corrected visual acuity and macular detachment in patients with chronic central serous chorioretinopathy. METHODS:Seventeen patients diagnosed with central serous chorioretinopathy were examined for gastric infection with Helicobacter pylori using the urease test and gastric biopsy.Helicobacter pylori-positive patients were treated with the appropriate ...
Tópico(s): Cancer Mechanisms and Therapy
2012 - Elsevier BV | Clinics

Jefferson Crespigio, L. C. L. Berbel, Marco Aurélio Dessimoni Dias, Rodrigo Fabri Berbel, Sofia S. Pereira, Duarte Pignatelli, Tânia Longo Mazzuco,
Tópico(s): Neuroblastoma Research and Treatments
2017 - Springer Science+Business Media | Journal of Endocrinological Investigation

Antônio Casella, Rodrigo Fabri Berbel, Eduardo de Souza, Michel Eid Farah,
The purpose of this study was to determine the value of spectral domain optical coherence tomography (SD-OCT) in assessing patients with diffuse unilateral subacute neuroretinitis (DUSN).This was an observational case series with clinical imaging correlation performed at the Retina and Vitreous Institute of Londrina and State University of Londrina, Paraná, Brazil. The series comprised ten consecutive patients with a confirmed diagnosis of DUSN, ie, seven patients with late-stage disease and three ...
Tópico(s): Amoebic Infections and Treatments
2014 - Dove Medical Press | Clinical ophthalmology

Rodrigo Fabri Berbel, Antônio Casella, Denise de Freitas, Ana Luísa Hofling‐Lima,
Purpose: The aim of this study was to report a case of a 52-year-old man with a rare fungal endophthalmitis after penetrating ocular trauma with a fish hook. Results: The patient was submitted to wound repair and hook extraction. Three weeks after the trauma, a cataract extraction with phacoemulsification and in-the-bag intraocular lens implantation was performed. After the development of endophthalmitis, vitrectomy and lens explantation with positive culture for Curvularia lunata were carried out. ...
Tópico(s): Ocular Surface and Contact Lens
2011 - Mary Ann Liebert, Inc. | Journal of Ocular Pharmacology and Therapeutics

Maria Lúcia Morcef Bouzada, Rodrigo Luiz Fabri, Mauro S. Nogueira, Tatiana Ungaretti Paleo Konno, Gizele G. Duarte, Elita Scio,
As part of a program oriented towards the discovery of bioactive natural products, 44 methanol extracts from 37 Brazilian traditional medicinal plants, most of them commonly used for treating conditions likely to be associated with microorganisms, were evaluated for their antibacterial activity and toxicity to brine shrimp. The agar-well diffusion method was used against Staphylococcus aureus, Pseudomonas aeruginosa, Salmonella typhimurium, Shigella sonnei, Klebsiella pneumoniae, Escherichia coli, ...
Tópico(s): Allelopathy and phytotoxic interactions
2009 - Taylor & Francis | Pharmaceutical Biology

Rodrigo Luiz Fabri, Mauro S. Nogueira, Fernanda Gambogi Braga, Elaine Soares Coimbra, Elita Scio,
The crude extract and the hexane, CH(2)Cl(2), EtOAc, n-BuOH, and hydromethanolic fractions of the aerial parts of Mitracarpus frigidus were evaluated against promastigote forms of two species of Leishmania (L. chagasi and L. amazonensis), 11 strains of bacteria (Staphylococcus aureus, Pseudomonas aeruginosa, Salmonella enterica sorovar Tythimurium, Shigella sonnei, Klebsiella pneumoniae, Escherichia coli, Micrococcus luteus, Enterococcus faecalis, Enterobacter cloacae, Streptococcus pyogenes and Bacillus ...
Tópico(s): Insect Pest Control Strategies
2008 - Elsevier BV | Bioresource Technology

Rodrigo Luiz Fabri, Mauro S. Nogueira, Jussara dos Reis Moreira, Maria Lúcia Morcef Bouzada, Elita Scio,
The methanolic extracts of the leaves of Lippia species (L. pseudo-thea, L. hermannioides, L. alba, L. rubella, and L. sidoides) were tested for their antibacterial, antifungal, and antioxidant activity. Cytotoxicity was determined by using brine shrimp lethality bioassay. Phytochemical screening was also performed. The extracts showed a minimum inhibitory concentration (MIC) ranging from 78 to 5000 μg/mL for antibacterial activity against at least 2 species of bacteria, although none was active against ...
Tópico(s): Phytochemicals and Antioxidant Activities
2011 - Mary Ann Liebert, Inc. | Journal of Medicinal Food

Rodrigo Luiz Fabri, Mauro S. Nogueira, Leandro B. Dutra, Maria Lúcia Morcef Bouzada, Elita Scio,
Espécies da família Asteraceae são amplamente utilizadas na medicina popular para diversos fins terapêuticos. Neste contexto, este estudo teve por objetivo averiguar a atividade antimicrobiana e antioxidante in vitro de extratos metanólicos de plantas pertencentes a Asteraceae, a maioria comumente utilizada na medicina tradicional. A prospecção química dos extratos também foi realizada. A atividade antimicrobiana foi avaliada pelo método de susceptibilidade em microdiluição em caldo e a atividade ...
Tópico(s): Natural product bioactivities and synthesis
2011 - UNIVERSIDADE EST.PAULISTA JÚLIO DE MESQUITA FILHO | Revista Brasileira de Plantas Medicinais

Fernanda Gambogi Braga, Maria Lúcia Morcef Bouzada, Rodrigo Luiz Fabri, Magnum de Oliveira Matos, Francis O. Moreira, Elita Scio, Elaine Soares Coimbra,
The antileishmanial and antifungal activity of 24 methanol extracts from 20 plants, all of them used in the Brazilian traditional medicine for the treatment of several infectious and inflammatory disorders, were evaluated against promastigotes forms of two species of Leishmania (L. amazonensis and L. chagasi) and two yeasts (Candida albicans and Cryptococcus neoformans). Among the 20 tested methanolic extracts, those of Vernonia polyanthes was the most active against L. amazonensis (IC50 of 4 μg/ml), ...
Tópico(s): Toxin Mechanisms and Immunotoxins
2006 - Elsevier BV | Journal of Ethnopharmacology

Rodrigo Luiz Fabri, Richard Michael Grazul, Lidiane Oliveira de Carvalho, Elaine Soares Coimbra, Gabriele Mendes Matos Cardoso, Elaine M. Souza–Fagundes, Adilson David da Silva, Elita Scio,
The bioactivity guided fractionation of the dichloromethane extract of Mitracarpus frigidus afforded the pyranonaphthoquinone psychorubrin. This compound, hitherto unknown in the genus Mitracarpus, had its biological activity evaluated against one panel of bacteria and two fungi, three tumor cell lines (HL60, Jurkat and MCF-7) and four Leishmania species. Its identity was confirmed unambiguously by ¹H, 13C, ¹H-COSY, IR and UV-Vis spectroscopy and mass spectrometry. Psychorubrin displayed a very promising ...
Tópico(s): Morinda citrifolia extract uses
2012 - Brazilian Academy of Sciences | Anais da Academia Brasileira de Ciências

Rodrigo Luiz Fabri, Elaine Soares Coimbra, Anna Christina de Almeida, Ezequias Pessoa de Siqueira, Tânia Maria de Almeida Alves, Carlos Leomar Zani, Elita Scio,
In our previous work (Fabri et al. 2009), we showed that different extracts of Mitracarpus frigidus had significant antibacterial, antifungal and leishmanicidal activities. In order to increase our knowledge about this species, this work assesses the chemical composition and the in vitro biological activity of its essential oil. Thus, the essential oil obtained by hydrodistillation of the aerial parts of M. frigidus was analyzed by GC/MS. Among several compounds detected, 11 were identified, being ...
Tópico(s): Ethnobotanical and Medicinal Plants Studies
2012 - Brazilian Academy of Sciences | Anais da Academia Brasileira de Ciências

Luciana Soares e Silva, Luciane Santos da Silva, Larissa Pereira Brumano, Paulo César Stringheta, Miriam Aparecida de Oliveira Pinto, Leticia Oliveira Moreira Dias, Camila De Sá Martins Muller, Elita Scio, Rodrigo Luiz Fabri, Helena Carla Castro, Maria da Penha Henriques do Amaral,
Guaco (Mikania glomerata Sprengel) syrup is one of the most popular herbal medicines used to treat the symptoms of asthmatic bronchitis, cough and hoarseness. The coumarin 2H-1-benzopyran-2-one, is one of the major constituents of Guaco and contributes to its pharmacological effects. The pharmaceutical capsule form of dry extract of Guaco is recommended by the Brazilian Program of Medicinal Plants and Herbal Medicines and used in primary health care. In order to identify a new protocol to obtain ...
Tópico(s): Essential Oils and Antimicrobial Activity
2012 - Multidisciplinary Digital Publishing Institute | Molecules

Rodrigo Luiz Fabri, Roberta Alvim Garcia, Jônatas Rodrigues Florêncio, Lidiane Oliveira de Carvalho, Nícolas de Castro Campos Pinto, Elaine Soares Coimbra, Elaine M. Souza–Fagundes, Antônia Ribeiro, Elita Scio,
Tópico(s): Natural Antidiabetic Agents Studies
2014 - Springer Science+Business Media | Medicinal Chemistry Research

Rodrigo Luiz Fabri, Danielle Maria de Oliveira Aragão, Jônatas Rodrigues Florêncio, Nícolas de Castro Campos Pinto, Ana Carolina Alves de Mattos, Paulo Marcos Zech Coelho, Maria Christina Marques Nogueira Castañon, Eveline Gomes Vasconcelos, Priscila de Faria Pinto, Elita Scio,
The aims of this work were to evaluate the in vitro and in vivo schistosomicidal properties of the methanolic extract of the aerial parts of Mitracarpus frigidus (MFM) and to determine its HPLC profile. For the in vitro experiment, four pairs of adult worms, obtained from infected mice, were exposed to different concentrations of MFM (100 to 400 μg/mL) for 24 and 48 h and analyzed under an inverted microscope. For the in vivo experiment, mice were inoculated with cercariae and, 20 days after infection, ...
Tópico(s): Ethnobotanical and Medicinal Plants Studies
2014 - Hindawi Publishing Corporation | BioMed Research International

Lucas Apolinário Chibli, Kamilla Coelho Morais Rodrigues, Carolina Miranda Gasparetto, Nícolas de Castro Campos Pinto, Rodrigo Luiz Fabri, Elita Scio, Maria Silvana Alves, Glauciemar Del-Vechio-Vieira, Orlando Vieira de Sousa,
Bryophyllum pinnatum (Lam.) Oken (Crassulaceae), popularly known in Brazil as "folha-da-fortuna", is a plant species used in folk medicine for the external and internal treatment of inflammation, infection, wound, burn, boil, ulcers and gastritis, and several other diseases. The present study aimed to perform the chemical characterization and the evaluation of the topical anti-inflammatory effect of the ethanol extract of Bryophyllum pinnatum leaves (EEBP) in acute and chronic mice ear edema models ...
Tópico(s): Phytochemistry and Biological Activities
2014 - Elsevier BV | Journal of Ethnopharmacology

Jucélia Barbosa da Silva, Vanessa dos Santos Temponi, Carolina Miranda Gasparetto, Rodrigo Luiz Fabri, Danielle Maria de Oliveira Aragão, Nícolas de Castro Campos Pinto, Antônia Ribeiro, Elita Scio, Glauciemar Del-Vechio-Vieira, Orlando Vieira de Sousa, Maria Silvana Alves,
The present study evaluated the antioxidant potential of Vernonia condensata Baker (Asteraceae). Dried and powdered leaves were exhaustively extracted with ethanol by static maceration followed by partition to obtain the hexane, dichloromethane, ethyl acetate, and butanol fractions. Total phenols and flavonoids contents were determined through spectrophotometry and flavonoids were identified by HPLC-DAD system. The antioxidant activity was assessed by DPPH radical scavenging activity, TLC-bioautography, ...
Tópico(s): Natural Antidiabetic Agents Studies
2013 - Hindawi Publishing Corporation | Oxidative Medicine and Cellular Longevity

Rodrigo Luiz Fabri, Roberta Alvim Garcia, Jônatas Rodrigues Florêncio, Nícolas de Castro Campos Pinto, Luiz Gustavo de Oliveira, Jair Adriano Kopke de Aguiar, Antônia Ribeiro, Elita Scio,
This study reports the in vivo anti-inflammatory and antioxidative effects of the methanolic extract of the aerial parts of Mitracarpus frigidus (MFM) and its chemical fingerprint.The acute anti-inflammatory activity was performed using the carrageenan-induced paw oedema and peritonitis, ear oedema induced by croton oil and ethyl phenylpropiolate methods. Total COX, COX-1 and COX-2 expression was also evaluated. Chronic activity was determined by cotton pellet granuloma model. The antioxidative activity ...
Tópico(s): Ethnobotanical and Medicinal Plants Studies
2013 - Oxford University Press | Journal of Pharmacy and Pharmacology

Rachel Rocha Pinheiro Machado, D. F. Jardim, Andrezza Rodrigues De Souza, Elita Scio, Rodrigo Luiz Fabri, Arthur G. Carpanez, Richard Michael Grazul, José Paulo Rodrigues Furtado de Mendonça, B. Lesche, Fernando Monteiro Aarestrup,
The anti-inflammatory and apoptotic activity of the essential oil of Syzygium cumini (L.) Skeels, Myrtaceae, leaves was investigated in vivo. The antiinflammatory action and chronic granulomatous inflammation in BALB/c mice, intravenously infected with Mycobacterium bovis, BCG, (Bacillo Calmet Guerim), was judged by measuring and classifying the granulomas formed in the hepatic parenchyma. The degree of apoptosis in the inflammatory cells was also measured. A reduction in the granulomatous area and ...
Tópico(s): Piperaceae Chemical and Biological Studies
2013 - Springer Science+Business Media | Revista Brasileira de Farmacognosia

Paula Marchesini, Alan Franco Barbosa, Viviane Zeringóta, Diego Melo, Tatiane Pinheiro Lopes Novato, Queli Cristina Fidelis, Rodrigo Luiz Fabri, Mário Geraldo de Carvalho, Armando Ubirajara Oliveira Sabaa‐Srur, Erik Daemon, Caio Márcio de Oliveira Monteiro,
We evaluated the acaricidal activity of Acmella oleracea methanol extract and spilanthol on Rhipicephalus microplus and Dermacentor nitens. The extract was made through maceration with methanol. From this extract, a dichloromethane fraction with 99% spilanthol was obtained and tested on R. microplus larvae and engorged females and D. nitens larvae. For evaluation against larvae, the modified larval packet test was used, and both the methanol extract and dichloromethane fraction were tested at concentrations ...
Tópico(s): Insect Pest Control Strategies
2016 - Elsevier BV | Veterinary Parasitology

F. X. de Araújo, Maurício Scholl Schell, Giovanni E Ferreira, Mariana Della Valentina Pessoa, Luiza Raulino de Oliveira, Brian Giacomini Borges, Fabrício Edler Macagnan, Rodrigo Della Méa Plentz, Marcelo Faria Silva,
ObjectiveTo compare the effects of two different mobilization techniques and a placebo intervention applied to the thoracic spine on heart rate variability (HRV) and pressure pain threshold (PPT) in asymptomatic individuals.MethodsSixty healthy asymptomatic subjects aged between 18 and 40 years old were randomized to a single session of one of the three interventions: posterior-to-anterior (PA) rotatory thoracic passive accessory intervertebral mobilization (PAIVM) (PA group), unilateral thoracic PA ...
Tópico(s): Myofascial pain diagnosis and treatment
2017 - Elsevier BV | Journal of Bodywork and Movement Therapies

Paula Marchesini, Alan Franco Barbosa, Cristiane Teixeira Franco, Tatiane Pinheiro Lopes Novato, Mirza Nalesso Gomes Sanches, Mário Geraldo de Carvalho, Rodrigo Luiz Fabri, Erik Daemon, Caio Márcio de Oliveira Monteiro,
This study evaluated the acaricidal activity of the methanol extract of Acmella oleracea with 0.187% of spilanthol against immature stages of Amblyomma sculptum. The packet test was used to evaluate the extract's activity on unengorged larvae and nymphs, testing concentrations of 0.4 to 50 mg/mL for larvae and 12.5 to 200.0 mg/mL for nymphs. For the engorged stages, the immersion test was used, at concentrations of 0.4 to 50 mg/mL for larvae and 12.5 to 200.0 mg/mL for nymphs. The methanol extract ...
Tópico(s): Complementary and Alternative Medicine Studies
2018 - Elsevier BV | Veterinary Parasitology

S Sartori, Cinara Stein, Christian Corrêa Coronel, Fabrício Edler Macagnan, Rodrigo Della Méa Plentz,
Patients with hypertension have altered autonomic nervous system function, which are increased sympathetic activity. Transcutaneous Electrical Nerve Stimulation (TENS) is a useful modality for pain control and has also been shown to be effective in the reduction of sympathetic activity in healthy subjects and individuals with cardiovascular diseases.The aim of this study was to verify the effects of transcutaneous electrical nerve stimulation by the evaluation of heart rate variability (HRV) in patients ...
Tópico(s): Infrared Thermography in Medicine
2018 - Bentham Science Publishers | Current Hypertension Reviews

Daniele da Cunha Ferreira, Miriam Allein Zago Marcolino, Fabrício Edler Macagnan, Rodrigo Della Méa Plentz, Adriana Kessler,
Scientific and technological advances, coupled with the work of multidisciplinary teams in intensive care units, have increased the survival of critically ill patients. An essential life support resource used in intensive care is extracorporeal membrane oxygenation. Despite the increased number of studies involving critically ill patients, few studies to date have demonstrated the safety and benefits of physical therapy combined with extracorporeal membrane oxygenation support. This review identified ...
Tópico(s): Intensive Care Unit Cognitive Disorders
2019 - Associação de Medicina Intensiva Brasileira | Revista Brasileira de Terapia Intensiva

Natália Prado da Silva, Eloá do Carmo Rapozo Lavinas Pereira, Lucas Mattos Duarte, Jhamine Caroline de Oliveira Freitas, Camila Guimarães de Almeida, Thiago P. Silva, Rossana C. N. Melo, Ana Carolina Morais Apolônio, Marcone Augusto Leal de Oliveira, Humberto de Mello Brandão, Frederico Pittella, Rodrigo Luiz Fabri, Guilherme Diniz Tavares, Priscila de Faria Pinto,
The purpose of this study was to develop tea tree oil (TTO)-loaded chitosan-poly(ε-caprolactone) core-shell nanocapsules (NC-TTO-Ch) aiming the topical acne treatment. TTO was analyzed by gas chromatography-mass spectrometry, and nanocapsules were characterized regarding mean particle size (Z-average), polydispersity index (PdI), zeta potential (ZP), pH, entrapment efficiency (EE), morphology by Atomic Force Microscopy (AFM), and anti-Cutibacterium acnes activity. The main constituents of TTO were terpinen- ...
Tópico(s): Advancements in Transdermal Drug Delivery
2020 - Elsevier BV | Colloids and Surfaces B Biointerfaces

Paula Marchesini, Alan Franco Barbosa, Mirza Nalesso Gomes Sanches, Rafael Moreira do Nascimento, Francisca Letícia Vale, Rodrigo Luiz Fabri, Ralph Maturano, Mário Geraldo de Carvalho, Caio Márcio de Oliveira Monteiro,
The present study was carried out to evaluate and compare the acaricidal activity of different fractions of Acmella oleracea methanolic extract, containing 0.0 % (F1), 24.5 % (F2), 48.0 % (F3) and 100 % (F4) of spilanthol, on unfed larvae and engorged females from the same Rhipicephalus microplus population. To obtain these fractions, the crude extract was subjected to different extraction procedures using increasingly polarized solvents to isolate the spilanthol compound. The Larval Packet Test was used to ...
Tópico(s): Insect Pest Control Strategies
2020 - Elsevier BV | Veterinary Parasitology