Ana Jiménez-Pastor, Ángel Alberich‐Bayarri, Rafael López‐González, David Martí‐Aguado, Manuela França, Rodrigo San Martin Bachmann, Juan Mazzucco, Luis Martí‐Bonmatí,
Tópico(s): Hepatocellular Carcinoma Treatment and Prognosis
2021 - Springer Science+Business Media | European Radiology
Produção Nacional
Revisado por pares
Aldo Araújo da Trindade Júnior, Yan Ferraz Ximenes Ladeira, Alexandre da Silva França, Rodrigo O. M. A. de Souza, Adolfo H. Moraes, Robert Wojcieszak, Ivaldo Itabaiana, Amanda Silva de Miranda,
During recent decades, the use of enzymes or chemoenzymatic cascades for organic chemistry has gained much importance in fundamental and industrial research. Moreover, several enzymatic and chemoenzymatic reactions have also served in green and sustainable manufacturing processes especially in fine chemicals, pharmaceutical, and flavor/fragrance industries. Unfortunately, only a few processes have been applied at industrial scale because of the low stabilities of enzymes along with the problematic ...
Tópico(s): Innovative Microfluidic and Catalytic Techniques Innovation
2021 - Multidisciplinary Digital Publishing Institute | Catalysts
Produção Nacional
Revisado por pares
Matheus de Castro Fonseca, Andressa França, Rodrigo M. Florentino, Roberta Cristelli Fonseca, Antônio Carlos Melo Lima Filho, Paula Teixeira Vieira Vidigal, A. G. de Oliveira, Laurent Dubuquoy, Michael H. Nathanson, M. Fátima Leite,
Hepatocyte proliferation during liver regeneration is a well-coordinated process regulated by the activation of several growth factor receptors, including the insulin receptor (IR). The IR can be localized in part to cholesterol-enriched membrane microdomains, but the role of such domains in insulin-mediated events in hepatocytes is not known. We investigated whether partitioning of IRs into cholesterol-enriched membrane rafts is important for the mitogenic effects of insulin in the hepatic cells. ...
Tópico(s): Liver Disease Diagnosis and Treatment
2018 - American Physiological Society | AJP Gastrointestinal and Liver Physiology
Produção Nacional
Revisado por pares
Fernanda Maria Policarpo Tonelli, Samyra Maria dos Santos Nassif Lacerda, Flávia Cristina Policarpo Tonelli, Guilherme Mattos Jardim Costa, Luiz R. França, Rodrigo R. Resende,
The history of transgenesis is marked by milestones such as the development of cellular transdifferentiation, recombinant DNA, genetic modification of target cells, and finally, the generation of simpler genetically modified organisms (e.g. bacteria and mice). The first transgenic fish was developed in 1984, and since then, continuing technological advancements to improve gene transfer have led to more rapid, accurate, and efficient generation of transgenic animals. Among the established methods ...
Tópico(s): RNA Interference and Gene Delivery
2017 - Elsevier BV | Biotechnology Advances
Produção Nacional
Revisado por pares
C. R. de Souza, Renata Vieira da Mota, Daniela Vieira Cardozo França, Rodrigo Meirelles de Azevedo Pimentel, Murillo de Albuquerque Regina,
The change of grape (Vitis vinifera) harvest from summer to winter through double pruning management has improved the fine wine quality in southern Brazil. High altitude, late cultivar and grafting combination all need to be investigated to optimize this new viticulture management. For this purpose, this study was carried out during the 2011 and 2012 growing seasons in a high altitude region of the state of Minas Gerais, Brazil, using eight grafting combinations for five year old Cabernet Sauvignon ...
Tópico(s): Postharvest Quality and Shelf Life Management
2015 - UNIVERSIDADE DE SÃO PAULO | Scientia Agricola
Produção Nacional
Revisado por pares
Gilberto Peixoto da Silva, Daniel R. Franco, Giovanni Chaves Stael, Maira da Costa de Oliveira Lima, Ricardo Sant'Anna Martins, Olívia de Moraes França, Rodrigo Bagueira de Vasconcellos Azeredo,
In this work, we evaluate two pore volume compressibility models that are currently discussed in the literature (Horne, 1990; Jalalh, 2006b). Five groups of carbonate rock samples from the three following sedimentary basins in North America that are known for their association with hydrocarbon deposits were selected for this study: (i) the Guelph Formation of the Michigan Basin (Middle Silurian); (ii) the Edwards Formation of the Central Texas Platform (Middle Cretaceous); and (iii) the Burlington-Keokuk ...
Tópico(s): Hydraulic Fracturing and Reservoir Analysis
2015 - Elsevier BV | Journal of Applied Geophysics
Produção Nacional
Revisado por pares
Carolina Campolina Rebello Horta, Bárbara Bruna Ribeiro Oliveira-Mendes, Anderson Oliveira do Carmo, Flávia Freire de Siqueira, Tatiana M. Barroca, Samyra Maria dos Santos Nassif Lacerda, Paulo Henrique Almeida Campos-Júnior, Luiz R. França, Rodrigo Lopes Ferreira, Evanguedes Kalapothakis,
lysophosphatidic acid lysophosphatidylcholine L. similis venom phospholipase D recombinant L. intermedia dermonecrotic protein 1 TO THE EDITOR Loxosceles spiders are a genus of arachnids, whose bites cause necrotizing skin lesions. They are distributed worldwide in temperate and tropical regions. In Brazil, approximately 10,000 cases of Loxosceles spider bites are reported annually. L. intermedia, L. gaucho, and L. laeta are prevalent in most of the southern states of Brazil, whereas L. similis ...
Tópico(s): Marine Invertebrate Physiology and Ecology
2013 - Elsevier BV | Journal of Investigative Dermatology
Produção Nacional
José Antônio Moreira Lima, Renato Parkinson Martins, C. A. S. Tanajura, Afonso M. Paiva, Mauro Cirano, Edmo Campos, Ivan Dias Soares, Gutemberg Borges França, Rodrigo De Souza Obino, João Bosco Rodrigues Alvarenga,
. This paper is concerned with the planning, implementation and some results of the Oceanographic Modeling and Observation Network (REMO) for Brazilian regional waters. Ocean forecasting has been an important scientific issue over the last decade due to studies related to climate change as well as applications related to short-range oceanic forecasts. It is a challenge to design an ocean forecasting system for a region with poor observational coverage of in situ data such as the South Atlantic Ocean. ...
Tópico(s): Climate variability and models
2013 - | Brazilian Journal of Geophysics
Produção Nacional
Revisado por pares
Tanin Kangwanpongpan, Francis França, Rodrigo Corrêa da Silva, Paulo Smith Schneider, Hans Joachim Krautz,
Oxy-fuel combustion is one of the promising options for carbon dioxide capture in future coal power plants. Radiative properties of combustion gases and heat transfer characteristics inside oxy-fuel furnaces are different from those found in air-fired furnace. Nowadays, few publications provide appropriate radiation property correlations for oxy-fuel conditions. The available correlations are based on previous versions of HITRAN database, which is not accurate for prediction of spectral intensities ...
Tópico(s): Combustion and flame dynamics
2012 - Elsevier BV | International Journal of Heat and Mass Transfer
Produção Nacional
Revisado por pares
Guilherme Rapozeiro França, Rodrigo Cesar Carvalho Freitas, Ana Lúcia Marques Ventura,
Abstract ATP is an important mitogen in the developing retina and its proliferative response decreases as chick retinal cells differentiate in culture. Both non‐stimulated or ATP‐induced proliferative response was abolished if cycling cells were cocultured with cells from older embryos or cultured with conditioned medium (CM) from postmitotic cells. The effect of CM was dose‐dependent and reversible, as removal of CM from the cultures restored both basal and ATP‐induced incorporation of [ 3 H]‐thymidine. ...
Tópico(s): Retinal Development and Disorders
2007 - Wiley | International Journal of Developmental Neuroscience
Produção Nacional
Revisado por pares
Leandro S. Oliveira, Adriana S. Franca, Rodrigo R.S. Camargos, Vany Ferraz,
A preliminary evaluation of the feasibility of producing biodiesel using oil extracted from defective coffee beans was conducted as an alternative means of utilizing these beans instead of roasting for consumption of beverage with depreciated quality. Direct transesterifications of triglycerides from refined soybean oil (reference) and from oils extracted from healthy and defective coffee beans were performed. Type of alcohol employed and time were the reaction parameters studied. Sodium methoxide ...
Tópico(s): Microbial Metabolic Engineering and Bioproduction
2007 - Elsevier BV | Bioresource Technology
Alessandra Silva Araújo, Gerlane Souza de Lima, Ihasmyn dos Santos Nunes, Júlio César Ribeiro de Oliveira Farias de Aguiar, Daniela Maria do Amaral Ferraz Navarro, Natália Ferrão Castelo Branco Melo, Nereide Stela Santos-Magalhães, Rodrigo França, Rafaela de Siqueira Ferraz Carvalho, Thayza Christina Montenegro Stamford,
The aim of this research was to develop an edible coating based on chitosan hydrochloride-gum arabic-passion fruit seed oil nanoparticles (PFSO-NP) with antifungal activity and preservative action, for maintenance of the physical-chemical quality parameters of strawberries during storage at 25 °C and 4 °C. Chitosan hydrochloride was obtained by dialysis of fungal chitosan, and the passion fruit seed oil was extracted by cold pressing. The nanoparticles elaborated by the complex coacervation technique ...
Tópico(s): Phytochemicals and Antioxidant Activities
2024 - Elsevier BV | Food Control
Produção Nacional
Revisado por pares
Fernanda Maria Policarpo Tonelli, Samyra Maria dos Santos Nassif Lacerda, M. A. Silva, E. S. Ávila, Luiz O. Ladeira, Luiz R. França, Rodrigo R. Resende,
Carboxi-functionalized multiwall carbon nanotubes (fMWCNTs), when complexed with DNA, can promote gene delivery to Nile tilapia spermatogonial stem cells with higher transfection efficiency than cationic lipids or electroporation, causing also less cell death.
Tópico(s): CRISPR and Genetic Engineering
2014 - Royal Society of Chemistry | RSC Advances
Produção Nacional
Revisado por pares
Marieke M van der Knoop, Reza Maroofian, Yuko Fukata, Yvette van Ierland, Ehsan Ghayoor Karimiani, Anna‐Elina Lehesjoki, Mikko Muona, Anders Paetau, Yuri Miyazaki, Yoko Hirano, Laila Selim, Marina de França, Rodrigo Ambrósio Fock, Christian Beetz, Claudia Ruivenkamp, Alison Eaton, Francois D Morneau-Jacob, Lena Sagi‐Dain, Lilach Shemer-Meiri, Amir Peleg, Jumana Haddad‐Halloun, D.J. Kamphuis, Cacha Peeters‐Scholte, Semra Hız Kurul, Rita Horváth, Hanns Lochmüller, David Murphy, Stephan Waldmüller, Stephanie Spranger, David Overberg, Alison M. Muir, Abolfazl Rad, Barbara Vona, Firdous Abdulwahad, Sateesh Maddirevula, Inna Povolotskaya, V. Yu. Voinova, Vykuntaraju K. Gowda, Varunvenkat M. Srinivasan, Fowzan S. Alkuraya, Heather C. Mefford, Majid Alfadhel, Tobias B. Haack, Pasquale Striano, Mariasavina Severino, Masaki Fukata, Yvonne Hilhorst‐Hofstee, Henry Houlden,
Abstract Pathogenic variants in A Disintegrin And Metalloproteinase (ADAM) 22, the postsynaptic cell membrane receptor for the glycoprotein leucine-rich repeat glioma-inactivated protein 1 (LGI1), have been recently associated with recessive developmental and epileptic encephalopathy. However, so far, only two affected individuals have been described and many features of this disorder are unknown. We refine the phenotype and report 19 additional individuals harbouring compound heterozygous or homozygous ...
Tópico(s): Genetics and Neurodevelopmental Disorders
2022 - Oxford University Press | Brain
Produção Nacional
Revisado por pares
Cinthya M. França, Rodrigo S. Couto, Pedro B. Velloso,
In an Internet of Things (IoT) environment, sensors collect and send data to application servers through IoT gateways. However, these data may be missing values due to networking problems or sensor malfunction, which reduces applications’ reliability. This work proposes a mechanism to predict and impute missing data in IoT gateways to achieve greater autonomy at the network edge. These gateways typically have limited computing resources. Therefore, the missing data imputation methods must be simple ...
Tópico(s): Traffic Prediction and Management Techniques
2021 - Multidisciplinary Digital Publishing Institute | Information
The use of nanoparticles as biomaterials with applications in the biomedical field is growing every day. These nanomaterials can be used as contrast imaging agents, combination therapy agents, and targeted delivery systems in medicine and dentistry. Usually, nanoparticles are found as synthetic or natural organic materials, such as hydroxyapatite, polymers, and lipids. Besides that, they are could also be inorganic, for instance, metallic or metal-oxide-based particles. These inorganic nanoparticles ...
Tópico(s): Graphene and Nanomaterials Applications
2022 - IOP Publishing | Biomedical Physics & Engineering Express
Maedeh Rahimnejad, Raziyehsadat Rezvaninejad, Rayehehossadat Rezvaninejad, Rodrigo França,
This review focuses on recently developed printable biomaterials for bone and mineralized tissue engineering. 3D printing or bioprinting is an advanced technology to design and fabricate complex functional 3D scaffolds, mimicking native tissue forin vivoapplications. We categorized the biomaterials into two main classes: 3D printing and bioprinting. Various biomaterials, including natural, synthetic biopolymers and their composites, have been studied. Biomaterial inks or bioinks used for bone and ...
Tópico(s): Additive Manufacturing and 3D Printing Technologies
2021 - IOP Publishing | Biomedical Physics & Engineering Express
The surface of any dental pulp-capping material has important implications for its clinical success because it is in direct contact with dental tissue, which influences its cytotoxicity. The aim was to determine the chemical composition of the first atomic layers of four pulp-protection agents because these atoms can initiate the pulp healing process. Biodentine (Septodont), ProRoot MTA (Dentsply), Dycal (Caulk) and TheraCal (Bisco) were prepared (n = 5) according to manufacturer recommendations. The chemical ...
Tópico(s): Bone Tissue Engineering Materials
2016 - Elsevier BV | Journal of Dentistry
Produção Nacional
Revisado por pares
Cristiana da Costa Luciano, Nancy Olson, Patricia DeGagne, Rodrigo França, Anaclara Ferreira Veiga Tipple, Michelle J. Alfa,
The objective of this study was to develop a new build up biofilm (BBF) model that was based on repeated exposure to test soil containing Enterococcus faecalis and Pseudomonas aeruginosa and repeated rounds of fixation to mimic the accumulation of patient material in endoscope channels during reprocessing. The new BBF model is a novel adaptation of the minimum biofilm effective concentration (MBEC) 96-well model where biofilm is formed on plastic pegs. The new MBEC-BBF model was developed over eight ...
Tópico(s): Foreign Body Medical Cases
2016 - Elsevier BV | Journal of Microbiological Methods
Natalia Giacomin, Marcelo V. Netto, André A. M. Torricelli, Gustavo K. Marino, Samir J. Bechara, Rodrigo França de Espíndola, Marcony R. Santhiago,
PURPOSE: To analyze the safety and efficacy of standard corneal collagen cross-linking (CXL) in advanced cases of progressive keratoconus after 4 years of follow-up. METHODS: A retrospective case series of patients with advanced progressive keratoconus (stages 3 and 4 of Amsler-Krumeich classification) underwent standard CXL treatment. The parameters examined were changes in uncorrected visual acuity (UDVA), corrected visual acuity (CDVA), keratometry values (mean, flat, steep, and apical), pachymetry, ...
Tópico(s): Corneal Surgery and Treatments
2016 - Slack Incorporated (United States) | Journal of Refractive Surgery
Gustavo K. Marino, André A. M. Torricelli, Natalia Giacomin, Marcony R. Santhiago, Rodrigo França de Espíndola, Marcelo V. Netto,
To evaluate the effectiveness and safety of accelerated corneal collagen cross-linking for postoperative LASIK ectasia after 2 years.A prospective, single-center case series was performed with patients treated for postoperative LASIK ectasia. All eyes underwent accelerated corneal collagen cross-linking (CCL-Vario Crosslinking; Peschke Meditrade GmbH, Zurich, Switzerland) at 9 mW/cm(2) for 10 minutes. The main outcome measures were changes in uncorrected distance visual acuity, corrected distance ...
Tópico(s): Ophthalmology and Visual Impairment Studies
2015 - Slack Incorporated (United States) | Journal of Refractive Surgery
Produção Nacional
Revisado por pares
Newton Kara-Júnior, Rodrigo França de Espíndola, João Valverde Filho, Christiane Pellegrino Rosa, A Ottoboni, Enis Donizete Silva,
OBJECTIVE: This study sought to describe and analyze ocular findings associated with nonocular surgery in patients who underwent general anesthesia.METHODS: The authors retrospectively collected a series of 39,431 surgeries using standardized data forms.RESULTS: Ocular findings were reported in 9 cases (2.3:10,000), which involved patients with a mean age of 58.9 ± 19.5 years.These cases involved patients classified as ASA I (33%), ASA II (55%) or ASA III (11%).General anesthesia with propofol and remifentanil ...
Tópico(s): Intraocular Surgery and Lenses
2015 - Elsevier BV | Clinics
Produção Nacional
Revisado por pares
Lorenna Oliveira Fernandes de Araujo, Oliver Silva Costa Barreto, Adriano Augusto Melo de Mendonça, Rodrigo França,
The aim of this study was to determine the degree of conversion (DC) for five orthodontic resins with different viscosities, to examine a probable relationship between the viscosity factor and the degree of conversion of the materials. Five commercially-available light-cured orthodontic bonding resins were used in this study: two medium viscosity resins [transbond XT (TR); opal bond MV (OB)]; two low viscosity resins [vertise flow (VF); opal bond flow (OF)]; and a fluoride-releasing sealant [opal seal (OS)]. ...
Tópico(s): Dental Erosion and Treatment
2015 - Springer Science+Business Media | Applied Adhesion Science
Rodrigo França, Taraneh Djavanbakht Samani, Ghislaine Bayade, L’Hocine Yahia, E. Sacher,
It is our aim to understand the mechanisms that make calcium phosphates, such as bioactive calcium hydroxyapatite (HA), and biphasic calcium (BCP) and β-tricalcium (β-TCP) phosphates, desirable for a variety of biological applications, such as the filling of bone defects. Here, we have characterized these materials by X-ray photoelectron spectroscopy (XPS), X-ray diffraction (XRD), scanning electron microscopy (SEM), Fourier-transform infrared (FTIR), time-of-flight secondary ion mass spectroscopy (TOF- ...
Tópico(s): Calcium Carbonate Crystallization and Inhibition
2014 - Elsevier BV | Journal of Colloid and Interface Science
Rodrigo França, Doris A. Mbeh, Taraneh Djavanbakht Samani, Canh Le Tien, Mircea Alexandru Mateescu, L’Hocine Yahia, E. Sacher,
Abstract The surfaces of three chitosan samples, differing only in their degrees of deacetylation and of carboxyethyl chitosan were chemically characterized by X‐ray photoelectron spectroscopy, time‐of‐flight secondary ion mass spectroscopy, X‐ray diffraction, and Fourier transform infrared, both before and after sterilization with ethylene oxide. Unexpected elemental ratios suggest that surface chemical modification occurred during the processing of the original chitin, with further surface modification ...
Tópico(s): Electrospun Nanofibers in Biomedical Applications
2013 - Wiley | Journal of Biomedical Materials Research Part B Applied Biomaterials
Produção Nacional
Revisado por pares
Rodrigo França de Espíndola, Emerson F.S. Castro, Marcony R. Santhiago, Newton Kara-Júnior,
OBJECTIVE: This study sought to compare the effects and outcomes of two ophthalmic viscosurgical devices, 1.6% hyaluronic acid/4.0%chondroitin sulfate and 2.0% hydroxypropylmethylcellulose, during phacoemulsification. METHODS:This prospective, randomized clinical trial comprised 78 eyes (39 patients) that received phacoemulsification performed by the same surgeon using a standardized technique.Patients were randomly assigned to receive either 1.6% hyaluronic acid/4.0%chondroitin sulfate or 2.0% hydroxypropylmethylcellulose ...
Tópico(s): Retinal and Macular Surgery
2012 - Elsevier BV | Clinics
Doris A. Mbeh, Rodrigo França, Yahye Merhi, Xuefeng Zhang, Teodor Veres, E. Sacher, L. Yahia,
Abstract In the biomedical field, nanomaterials have the potential for use in the targeted delivery of drugs in the human body and in the diagnosis and therapy of certain diseases. In the category of targeted delivery, magnetite (Fe 3 O 4 ) nanoparticles have received much attention. As with any similar new therapy, when such nanoparticles are functionalized with chemical groups designed to permit the specific attachment of drugs, cytotoxicological testing is necessary before moving to animal models. ...
Tópico(s): Graphene and Nanomaterials Applications
2012 - Wiley | Journal of Biomedical Materials Research Part A
Rodrigo França, Xuefeng Zhang, Teodor Veres, L’H. Yahia, E. Sacher,
Numerous samples of [email protected] and [email protected]@silane core–shell nanoparticles, previously used as prodrugs, were prepared by an experienced chemist, using the same identical equipment and the same lots of reagents. Their surface analyses showed batch-to-batch chemical variations: no two batches were found to have the same surface chemistries, showing unexpected Si–O bond scission and amine oxidation. Because the preparations used reactions recognized to be mild, and bond scission and ...
Tópico(s): Iron oxide chemistry and applications
2012 - Elsevier BV | Journal of Colloid and Interface Science
Produção Nacional
Revisado por pares
Newton Kara-Júnior, Rodrigo França de Espíndola, Beatriz A.F. Gomes, Bruna V. Ventura, David Smadja, Marcony R. Santhiago,
PURPOSE: To evaluate the possible side effects and potential protection 5 years after implantation of an intraocular lens (IOL) with a blue-light filter (yellow tinted). SETTING: Ophthalmology Department, University of São Paulo, São Paulo, Brazil. DESIGN: Prospective randomized clinical study. METHODS: Patients with bilateral visually significant cataract randomly received an ultraviolet (UV) and blue light–filtering IOL (Acrysof Natural SN60AT) in 1 eye and an acrylic UV light–filtering only IOL (Acrysof ...
Tópico(s): Corneal surgery and disorders
2011 - Lippincott Williams & Wilkins | Journal of Cataract & Refractive Surgery
Produção Nacional
Revisado por pares
Marcony R. Santhiago, Steven E. Wilson, Marcelo V. Netto, Rodrigo França de Espíndola, Ravindra A Shah, Ramon Coral Ghanem, Samir J. Bechara, Newton Kara-Júnior,
To determine whether implantation of a multifocal intraocular lens (IOL) with a lower addition (+3.00 diopters [D]) at the lens plane results in better intermediate visual acuity 1 year after surgery compared with a multifocal IOL with higher addition (+4.00 D).This prospective, randomized, double-masked study included 80 eyes from 40 patients. Twenty patients were implanted bilaterally with the ReSTOR +3.00-D add IOL and 20 patients were implanted bilaterally with the ReSTOR +4.00-D add IOL. Primary outcome ...
Tópico(s): Corneal surgery and disorders
2011 - Slack Incorporated (United States) | Journal of Refractive Surgery