Roel Brouwers, Frederiek Schoubben, Cynthia Van Hulle, Steve Van Uytbergen,
This paper studies the impact of verified emissions publications in the European Emissions Trading Scheme (EU ETS) on the market value of participating companies. Using event study methodology on a unique sample of 368 listed companies, we show that verified emissions only resulted in statistically significant market responses when the carbon price was high and allowance scarcity was anticipated. The cross-section analysis of abnormal returns surrounding the publication of verified emissions shows ...
Tópico(s): Capital Investment and Risk Analysis
2016 - Elsevier BV | Energy Policy
Roel Brouwers, Frederiek Schoubben, Cynthia Van Hulle,
Abstract In this study we examine, within the context of the European Union Emission Trading Scheme, whether firms' ability to pass through carbon costs affects the link between carbon emission and corporate financial performance. Our results, controlling for the endogenous relationship between carbon emission and financial performance, and robust to a number of alternative financial performance measures, demonstrate that good carbon emission performance does not always pay off. In fact, we find ...
Tópico(s): Climate Change Policy and Economics
2018 - Wiley | Business Strategy and the Environment
Roel Brouwers, Frederiek Schoubben, Cynthia Van Hulle,
This article studies the relationship between firm-level emissions-to-cap ratio (ETC) and environmental abatement, by using a unique and extensive data set of 10 762 installations covered by the European Union Emission Trading Scheme (EU ETS) matched to 5931 firms. We find that a shortage of emissions allowances is related to more abatement in later years while a surplus of emissions allowances results in worse subsequent environmental performance. This finding underscores the importance of reducing ...
Tópico(s): Corporate Social Responsibility Reporting
2016 - Taylor & Francis | Applied Economics Letters
K.P. Belkhale, Roel Brouwer, P. Banerjee,
Two approaches to handling the computational requirements of computer-aided design problems are considered. One approach is to take advantage of the hierarchical nature of circuit design and develop hierarchical CAD algorithms. Another involves the use of parallel processing and development of parallel CAD algorithms. How these two approaches can be combined to speed up various CAD applications is discussed. Toward this goal, two general problems in scheduling are solved: parallelizable independent ...
Tópico(s): Scheduling and Optimization Algorithms
1993 - Institute of Electrical and Electronics Engineers | IEEE Transactions on Computer-Aided Design of Integrated Circuits and Systems
Werner Vogels, Mark Roel Dekker, Wiebo Brouwer, Ritske de Jong,
The primary purpose of the study was to identify event-based prospective-memory tasks that provide sensitive and reliable tools for assessing effects of normal aging in prospective-memory performance. Four prospective-memory tasks were selected from the literature or were newly developed, with the tasks differing on various dimensions that, for theoretical reasons or based on previous evidence, might determine task sensitivity to age effects on prospective-memory performance: perceptual saliency ...
Tópico(s): EEG and Brain-Computer Interfaces
2002 - Elsevier BV | Brain and Cognition
T. Schneider, Roel Vermeulen, Derk Brouwer, John W. Cherrie, Hans Kromhout, C.L. Fogh,
Dermal exposure, primarily to pesticides, has been measured for almost half a century. Compared with exposure by inhalation, limited progress has been made towards standardisation of methods of measurement and development of biologically relevant exposure measures. It is suggested that the absence of a consistent terminology and a theoretical model has been an important cause of this lack of progress. Therefore, a consistent terminology based on a multicompartment model for assessment of dermal ...
Tópico(s): Chemical Safety and Risk Management
1999 - BMJ | Occupational and Environmental Medicine
R. Lauwerys, J. P. Buchet, Harry A. Roels, J. J. M. Brouwers, Dan Stánescu,
Pulmonary ventilatory function and various biological indices have been investigated in three groups of workers exposed to cadmium dust (women with less than 20 years' exposure [E1], men with less than 20 years' exposure [E2], and men with more than 20 years' exposure [E3]) and in three matched control groups. The current airborne Cd dust concentration in the workrooms was below the actual American threshold limit value (200μg/cu m). A slight but significant reduction in forced vital capacity, in forced ...
Tópico(s): Carcinogens and Genotoxicity Assessment
1974 - Heldref Publications | Archives of Environmental Health An International Journal
R. Lauwerys, J. P. Buchet, Harry A. Roels, J. J. M. Brouwers, Dan Stánescu,
Tópico(s): Heavy Metal Exposure and Toxicity
1974 - Heldref Publications | Archives of Environmental Health An International Journal
Anne de Leeuw, Adriaan Brouwer, Roel J. Barelds, Dick Knook,
Sinusoidal liver cells were isolated from the livers of 3-, 12-, 30-, and 36-month-old female BN/ BiRij rats by enzymatic digestion. The Kupffer cells in the sinusoidal eel suspensions were purified by centrifugal elutriation and kept in maintenance culture for periods of up to about 3 weeks. The viability and yield of Kupffer cells per gram of body weight did not change with the age of the donor rat. The ultrastructural, cytochemical, and functional characteristics of Kupffer cells as observed ...
Tópico(s): Neonatal Respiratory Health Research
1983 - Lippincott Williams & Wilkins | Hepatology
Adriaan Brouwer, Roel J. Barelds, Dick Knook,
There are many indications that the functional capacity of the reticuloendothelial system (RES) declines with age. The aim of this study was to investigate the cellular basis of age-related changes in the clearance function of the RES. The experiments were focused mainly on Kupffer and endothelial cells of the liver which represent a major part of the RES and are primarily responsible for clearance of colloidal material from the circulation. The clearance capacity of the RES was tested clinically ...
Tópico(s): Proteoglycans and glycosaminoglycans research
1985 - Lippincott Williams & Wilkins | Hepatology
Anne-Marie Brouwer, Roel J. Barelds, A.M. de Leeuw, E. Blauw, A. Plas, Sing Hiem Yap, Anja M.W.C. van den Broek, D.L. Knook,
Kupffer cells and other sinusoidal cells were isolated after perfusion and incubation with pronase and collagenase of pieces of liver tissue obtained from organ donors. The resulting cell preparations contained endothelial cells, Kupffer cells and fat-storing cells as well as considerable numbers of leucocytes. Attempts to purify the different sinusoidal cell types by density centrifugation and centrifugal elutriation were successful only for Kupffer cells. Kupffer cells, in contrast to endothelial ...
Tópico(s): Infant Nutrition and Health
1988 - Elsevier BV | Journal of Hepatology
Jerry Spanjer, Boudien Krol, Sandra Brouwer, Roel Popping, Johan W. Groothoff, Jac J. L. van der Klink,
The aim of this study is to investigate the reliability and validity of the Disability Assessment Structured Interview (DASI). The DASI is a semi-structured interview for assessing long-term functional limitations concerning the work disability assessment of claimants.A randomized controlled trial was conducted. Patients applying for a work-disability pension after 21 months of sick leave were independently interviewed and examined either by two physicians who had completed a DASI training period ( ...
Tópico(s): Medical Malpractice and Liability Issues
2009 - Springer Science+Business Media | Journal of Occupational Rehabilitation
Berna van Wendel de Joode, Derk Brouwer, Roel Vermeulen, J.J. van Hemmen, Dick Heederik, Hans Kromhout,
This paper describes a new method (DREAM) for structured, semi-quantitative dermal exposure assessment for chemical or biological agents that can be used in occupational hygiene or epidemiology. It is anticipated that DREAM could serve as an initial assessment of dermal exposure, amongst others, resulting in a ranking of tasks and subsequently jobs. DREAM consists of an inventory and evaluation part. Two examples of dermal exposure of workers of a car-construction company show that DREAM characterizes ...
Tópico(s): Pesticide Exposure and Toxicity
2002 - Oxford University Press | The Annals of Occupational Hygiene
Roel Bisschop, Reinoud W. Brouwer, Jos J. A. M. van Raay,
Total knee arthroplasty (TKA) is a well-established treatment at the end stage of a degenerated knee joint. This operative treatment generally relieves pain, improves physical function, and has a high level of patient satisfaction, especially in the elderly. Younger patients, however, are demanding and have a higher level of physical activity compared to elderly patients. One could therefore expect more mechanical problems such as prosthetic loosening and polyethylene wear after long-term follow- ...
Tópico(s): Orthopedic Infections and Treatments
2010 - Slack Incorporated (United States) | Orthopedics
Charlotte L. Brouwer, Roel J.H.M. Steenbakkers, Edwin R. van den Heuvel, J. Duppen, Arash Navran, Henk P. Bijl, O. Chouvalova, Fred R. Burlage, H. Meertens, Johannes A. Langendijk, A.A. van ‘t Veld,
Consistent delineation of patient anatomy becomes increasingly important with the growing use of highly conformal and adaptive radiotherapy techniques. This study investigates the magnitude and 3D localization of interobserver variability of organs at risk (OARs) in the head and neck area with application of delineation guidelines, to establish measures to reduce current redundant variability in delineation practice. Interobserver variability among five experienced radiation oncologists was studied ...
Tópico(s): Lung Cancer Diagnosis and Treatment
2012 - BioMed Central | Radiation Oncology
Maarten R. Huizinga, Reinoud W. Brouwer, Roel Bisschop, Hugo C. van der Veen, Inge van den Akker‐Scheek, Jos J. A. M. van Raay,
The aims of this study were to determine survival rate, the clinical performance, and radiologic results of an Anatomic Graduated Component (AGC) total knee arthroplasty (TKA). Survival analysis was assessed by analyzing all hospital records of 211 AGC TKAs in 177 patients after 15 to 20 years. The survival rate was 87%, with failure defined as revision for any reason including infection. The main reasons for failure were infection and failure of the metal-backed patellar component. Clinical evaluation ...
Tópico(s): Orthopedic Infections and Treatments
2012 - Elsevier BV | The Journal of Arthroplasty
Mingyao Zhu, K Bzdusek, C. Brink, Jesper Grau Eriksen, Olfred Hansen, Helle Anita Jensen, Hiram A. Gay, Wade L. Thorstad, Joachim Widder, Charlotte L. Brouwer, Roel J.H.M. Steenbakkers, H.A.M. Vanhauten, Jeffrey Cao, Gail McBrayne, Salil Patel, Donald M. Cannon, Nicholas Hardcastle, Wolfgang A. Tomé, Matthias Guckenberg, Parag J. Parikh,
Purpose Clinical validation and quantitative evaluation of computed tomography (CT) image autosegmentation using Smart Probabilistic Image Contouring Engine (SPICE). Methods and Materials CT images of 125 treated patients (32 head and neck [HN], 40 thorax, 23 liver, and 30 prostate) in 7 independent institutions were autosegmented using SPICE and computational times were recorded. The number of structures autocontoured were 25 for the HN, 7 for the thorax, 3 for the liver, and 6 for the male pelvis ...
Tópico(s): Medical Imaging and Analysis
2013 - Elsevier BV | International Journal of Radiation Oncology*Biology*Physics
Charlotte L. Brouwer, Roel J.H.M. Steenbakkers, Jean Bourhis, Wilfried Budach, Cai Grau, Vincent Grégoire, Marcel van Herk, Anne Lee, P. Maingon, Chris Nutting, Brian O’Sullivan, Sandro Porceddu, David I. Rosenthal, Nanna M. Sijtsema, Johannes A. Langendijk,
PurposeThe objective of this project was to define consensus guidelines for delineating organs at risk (OARs) for head and neck radiotherapy for routine daily practice and for research purposes.MethodsConsensus guidelines were formulated based on in-depth discussions of a panel of European, North American, Asian and Australian radiation oncologists.ResultsTwenty-five OARs in the head and neck region were defined with a concise description of their main anatomic boundaries. The Supplemental material ...
Tópico(s): Radiation Dose and Imaging
2015 - Elsevier BV | Radiotherapy and Oncology
Sandra Brouwer, Roel Bakker, J.M.H. Schellekens,
The aim of the present study was to examine which personal and situational factors affect reemployment success in persons in their first year of unemployment. In a prospective cohort study with a one-year follow-up, we investigated a sample of 3618 subjects who became unemployed. A survey was sent to all participants, including personal and situational factors, based on Wanberg's model, the Theory of Planned Behavior model and the Valence–Instrumentality–Expectancy model. Our results showed that ...
Tópico(s): Workplace Health and Well-being
2015 - Elsevier BV | Journal of Vocational Behavior
Charlotte L. Brouwer, Roel J.H.M. Steenbakkers, Johannes A. Langendijk, Nanna M. Sijtsema,
In the last decade, many efforts have been made to characterize anatomic changes of head and neck organs at risk (OARs) and the dosimetric consequences during radiotherapy. This review was undertaken to provide an overview of the magnitude and frequency of these effects, and to investigate whether we could find criteria to identify head and neck cancer patients who may benefit from adaptive radiotherapy (ART). Possible relationships between anatomic and dosimetric changes and outcome were explicitly ...
Tópico(s): Lung Cancer Diagnosis and Treatment
2015 - Elsevier BV | Radiotherapy and Oncology
Cindy Bekker, Eelco Kuijpers, Derk Brouwer, Roel Vermeulen, Wouter Fransman,
Background:Occupational exposure to manufactured nano-objects and their agglomerates, and aggregates (NOAA) has been described in several workplace air monitoring studies. However, data pooling for general conclusions and exposure estimates are hampered by limited exposure data across the occupational life cycle of NOAA and a lack in comparability between the methods of collecting and analysing the data. By applying a consistent method of collecting and analysing the workplace exposure data, this ...
Tópico(s): Occupational exposure and asthma
2015 - Oxford University Press | The Annals of Occupational Hygiene
Charlotte L. Brouwer, Roel J.H.M. Steenbakkers, A. van der Schaaf, Chantal T.C. Sopacua, Lisanne V. van Dijk, R.G.J. Kierkels, Hendrik P. Bijl, Johannes G. M. Burgerhof, Johannes A. Langendijk, Nanna M. Sijtsema,
The aim of this study was to develop and validate a method to select head and neck cancer patients for adaptive radiotherapy (ART) pre-treatment. Potential pre-treatment selection criteria presented in recent literature were included in the analysis.Deviations from the planned parotid gland mean dose (PG ΔDmean) were estimated for 113 head and neck cancer patients by re-calculating plans on repeat CT scans. Uni- and multivariable linear regression analyses were performed to select pre-treatment parameters, ...
Tópico(s): Lung Cancer Diagnosis and Treatment
2016 - Elsevier BV | Radiotherapy and Oncology
Charlotte L. Brouwer, Roel J.H.M. Steenbakkers, Elske M. Gort, Marije E. Kamphuis, Hans Paul van der Laan, A.A. van't Veld, Nanna M. Sijtsema, Johannes A. Langendijk,
PurposeTo test the hypothesis that delineation of swallowing organs at risk (SWOARs) based on different guidelines results in differences in dose–volume parameters and subsequent normal tissue complication probability (NTCP) values for dysphagia-related endpoints.Materials and methodsNine different SWOARs were delineated according to five different delineation guidelines in 29 patients. Reference delineation was performed according to the guidelines and NTCP-models of Christianen et al. Concordance ...
Tópico(s): Esophageal and GI Pathology
2014 - Elsevier BV | Radiotherapy and Oncology
Joseph S. Bukalasa, Bert Brunekreef, Maartje Brouwer, Roel Vermeulen, Johan C. de Jongste, Lenie van Rossem, Judith M. Vonk, Alet H. Wijga, Anke Huss, Ulrike Gehring,
Agricultural pesticides are frequently used for crop protection. Residents living in close proximity to treated fields may be exposed to these pesticides. There is some indication that children living near agricultural fields have an increased risk of developing asthma and decreased lung function. The aim of this study was to assess the proximity of participants' homes to fields likely treated with pesticides as proxy for environmental exposure to agricultural pesticides among participants of a ...
Tópico(s): Environmental Justice and Health Disparities
2017 - Elsevier BV | The Science of The Total Environment
J.J. Emeis, Anne-Marie Brouwer, Roel J. Barelds, MichaelA. Horan, SR Durham, T. Kooistra,
Summary Aged rats are more susceptible to endotoxin-induced effects, including microthrombosis and platelet aggregation, than are young rats. To investigate whether changes in the fibrinolytic system might be involved, we investigated the fibrinolytic activity in plasma euglobulin fractions and tissues (lung and heart) of young (6-months old) and aged (24-months old) rats under baseline conditions and after challenge with endotoxin. Aged rats had lower plasma levels of tissue-type plasminogen activator ( ...
Tópico(s): Protease and Inhibitor Mechanisms
1992 - Thieme Medical Publishers (Germany) | Thrombosis and Haemostasis
Saskia B. Wortmann, Marc Espeel, Lígia S. Almeida, Annette Reimer, Dennis Bosboom, Frank Roels, Arjan P.M. de Brouwer, Ron A. Wevers,
Abstract Since the proposal to define a separate subgroup of inborn errors of metabolism involved in the biosynthesis and remodelling of phospholipids, sphingolipids and long chain fatty acids in 2013, this group is rapidly expanding. This review focuses on the disorders involved in the biosynthesis of phospholipids. Phospholipids are involved in uncountable cellular processes, e.g. as structural components of membranes, by taking part in vesicle and mitochondrial fusion and fission or signal transduction. ...
Tópico(s): Erythrocyte Function and Pathophysiology
2014 - Springer Science+Business Media | Journal of Inherited Metabolic Disease
Jerry Spanjer, B. Krol, Roel Popping, JW Groothoff, Sandra Brouwer,
Objective: To investigate whether the provision of detailed information on participation and activity limitations, compared with medical information alone, influences the assessment of work limitations by physicians.Methods: Three groups each of 9 insurance physicians used written interview reports to assess work limitations in 30 patients with low back pain or lower extremity problems. Each group was given different kinds of information on the patient: the first group received only medical information; ...
Tópico(s): Health Systems, Economic Evaluations, Quality of Life
2009 - Foundation for Rehabilitation Information | Journal of Rehabilitation Medicine
Bieke Decaesteker, Amber Louwagie, Siebe Loontiens, Fanny De Vloed, Sarah-Lee Bekaert, Juliette Roels, Suzanne Vanhauwaert, Sara De Brouwer, Ellen Sanders, Alla Berezovskaya, Geertrui Denecker, Eva D’haene, Stéphane Van Haver, Wouter Van Loocke, Jo Van Dorpe, David Creytens, Nadine Van Roy, Tim Pieters, Christophe Van Neste, Matthias Fischer, Pieter Van Vlierberghe, Stephen S. Roberts, Johannes H. Schulte, Sara Ek, Rogier Versteeg, Jan Köster, Johan van Nes, Mark W. Zimmerman, Katleen De Preter, Frank Speleman,
Abstract The pediatric extra-cranial tumor neuroblastoma displays a low mutational burden while recurrent copy number alterations are present in most high-risk cases. Here, we identify SOX11 as a dependency transcription factor in adrenergic neuroblastoma based on recurrent chromosome 2p focal gains and amplifications, specific expression in the normal sympatho-adrenal lineage and adrenergic neuroblastoma, regulation by multiple adrenergic specific (super-)enhancers and strong dependency on high ...
Tópico(s): Protein Degradation and Inhibitors
2023 - Nature Portfolio | Nature Communications
Michael A. Horan, Adriaan Brouwer, Roel J. Barelds, Rene Wientjens, Stephen K. Durham, Dick Knook,
In this paper we describe the influence of ageing on responses to intravenously-injected endotoxin in two rat strains. Old age had no apparent effect on the absorption of 51Cr-labelled endotoxin from either jejunum or colon. Notwithstanding, aged animals appeared much more sensitive than their young counterparts to the lethal effects of intravenously injected endotoxin. Old animals exhibited virtually 100% mortality over the dose range 1–4 mg/100 g body weight while only sporadic deaths were seen ...
Tópico(s): Adipose Tissue and Metabolism
1991 - Elsevier BV | Mechanisms of Ageing and Development
Janke Schinkel, Miranda Langendam, Roel A. Coutinho, Anneke Krol, Margreet Brouwer, Hanneke Schuitemaker,
The relationship between CCR5 and CCR2b genotypes and human immunodeficiency virus (HIV)-1 disease progression was studied among the 108 seroconverters of the Amsterdam cohort of injecting drug users (IDUs). In contrast to earlier studies among homosexual men, no effect on disease progression of the CCR5 Δ32/+ and the CCR2b 64I/+ genotypes was found, when progression to AIDS, death, or a CD4 cell count <200/μL was compared by a Cox proportional hazards model. Furthermore, CD4 cell decline (by a regression ...
Tópico(s): Hepatitis C virus research
1999 - Oxford University Press | The Journal of Infectious Diseases