J. Carlos Arauz, Rolando Fonseca,
We treated ten patients with Wegener's granulomatosis whose clinical picture differed only in the stage of the disease at the time of the first visit. All patients were female with a mean age of 30 years and all presented with a picture of high tracheal obstruction. Three died and six have a permanent tracheostomy. Surgical treatment was unsuccessful; corticosteroids provided only transient improvement but cyclophosphamide induced remission. Removal of the stenosis either by open surgery or endoscopically ...
Tópico(s): Tracheal and airway disorders
1982 - SAGE Publishing | Annals of Otology Rhinology & Laryngology
Daniel G. Olmedo, Moisés Rosenberg, Rolando Fonseca,
Tópico(s): Tracheal and airway disorders
1982 - Elsevier BV | CHEST Journal
Aquiles J. Roncoroni, Ricardo J.M. Puy, Ellen F. Goldman, Rolando Fonseca, Daniel G. Olmedo,
Abstract Background Since its first appearance in December 2019, the novel Severe Acute Respiratory Syndrome Coronavirus type 2 (SARS-CoV-2), spread worldwide causing an increasing number of cases and deaths (35,537,491 and 1,042,798, respectively at the time of writing, https://covid19.who.int). Similarly, the number of complete viral genome sequences produced by Next Generation Sequencing (NGS), increased exponentially. NGS enables a rapid accumulation of a large number of sequences. However, bioinformatics ...
Tópico(s): Respiratory viral infections research
1973 - BMJ | Thorax
Yudibeth Sixto‐López, Martiniano Bello, Rolando Alberto Rodríguez-Fonseca, Martha Cecilia Rosales‐Hernández, Marlet Martínez‐Archundia, José A. Gómez-Vidal, José Correa‐Basurto,
Histone deacetylases (HDACs) are a family of proteins involved in the deacetylation of histones and other non-histones substrates. HDAC6 belongs to class II and shares similar biological functions with others of its class. Nevertheless, its three-dimensional structure that involves the catalytic site remains unknown for exploring the ligand recognition properties. Therefore, in this contribution, homology modeling, 100-ns-long Molecular Dynamics (MD) simulation and docking calculations were combined ...
Tópico(s): Chemical Synthesis and Analysis
2016 - Taylor & Francis | Journal of Biomolecular Structure and Dynamics
Alberto Martínez-Muñoz, Martiniano Bello, Aurelio Romero‐Castro, Rolando Alberto Rodríguez-Fonseca, João Rodrigues, Víctor Armando Sánchez-Espinosa, José Correa‐Basurto,
Tópico(s): Chemical Synthesis and Analysis
2017 - Elsevier BV | Journal of Molecular Graphics and Modelling
Rolando Alberto Rodríguez-Fonseca, Martiniano Bello, María Ángeles de los Muñoz-Fernández, Javier López Jiménez, Saúl Rojas-Hernández, Manuel Jonathan Fragoso-Vázquez, Mara Gutiérrez‐Sánchez, João Rodrigues, N. Cayetano-Castro, Raúl Borja‐Urby, Octavio Rodríguez‐Cortés, Jazmín García‐Machorro, José Correa‐Basurto,
Peptide epitopes have been widely used to develop synthetic vaccines and immunotherapies. However, peptide epitopes may exhibit poor absorption or immunogenicity due to their low molecular weights. Conversely, fourth-generation polyamidoamine (G4-PAMAM) dendrimers are nonimmunogenic and relatively nontoxic synthetic nanoparticles that have been used as adjuvants and nanocarriers of small peptides and to improve nasal absorption. Based on this information, we hypothesized that the combination of intranasal ...
Tópico(s): HIV Research and Treatment
2019 - Elsevier BV | Colloids and Surfaces B Biointerfaces
Rolando Alberto Rodríguez-Fonseca, Yudibeth Sixto‐López, Fragoso-Vazquez Manuel Jonathan, Raúl Flores-Mejía, Cabrera-Perez Laura Cristina, Ismael Vázquez-Moctezuma, Rosales-Hernandez Martha Cecilia, Martiniano Bello, Marlet Martínez‐Archundia, Trujillo-Ferrara José Guadalupe, Elvia Becerra‐Martínez, José Correa‐Basurto,
The epigenetic regulation of genes in cancer could be targeted by inhibiting Histone deacetylase 6 (HDAC6), an enzyme involved in several types of cancer such as lymphoma, leukemia, ovarian cancer, etc.Through in silico methods, a set of Phenyl butyric acid derivatives with possible HDAC6 inhibitory activity were designed, rendering monophenylamides and biphenylamides using tubacin (HDAC6 selective inhibitor) as reference.The target compounds were submitted to theoretical ADMET analyses and their ...
Tópico(s): Click Chemistry and Applications
2017 - Bentham Science Publishers | Anti-Cancer Agents in Medicinal Chemistry
Ricardo Rolando Fonseca Saldaña, Adán Humberto Estela Estela,
Los viajes que realizan los turistas han cambiado en los últimos años. El avance tecnológico impulsa la competitividad y da inicio a modelos de negocios, plataformas e intercambios conocidos como economía colaborativa. Airbnb es una plataforma web preferida por usuarios que desean alquilar un espacio a viajeros que buscan alojamiento, esto por la flexibilidad de precios en comparación con los hoteles. Airbnb es un negocio que aumenta a pesar de la desconfianza de hospedar a extraños. Los millennials ...
Tópico(s): Transportation and Mobility Innovations
2020 - | Gestión en el Tercer Milenio
Martiniano Bello, Concepción Guadarrama-García, Rolando Alberto Rodríguez-Fonseca,
Tópico(s): Cancer therapeutics and mechanisms
2019 - Springer Science+Business Media | Journal of Computer-Aided Molecular Design
Rolando Alberto Rodríguez-Fonseca, Martiniano Bello, Saúl Rojas‐Hernández, Jazmín García‐Machorro, Mara Gutiérrez‐Sánchez, Alan Rubén Estrada-Pérez, Manuel Jonathan Fragoso-Vázquez, Juan Vicente Méndez‐Méndez, José Correa‐Basurto,
Novel synthetic vaccines as immunotherapy approaches for HIV are interesting strategies that imply big challenges as they increase the poor immunogenic properties of peptide epitopes and their structural damage from the physiological environment.
Tópico(s): HIV Research and Treatment
2020 - Royal Society of Chemistry | RSC Advances
Martiniano Bello, Rolando Alberto Rodríguez-Fonseca, José Correa‐Basurto,
Tópico(s): HIV Research and Treatment
2019 - Elsevier BV | Journal of Molecular Graphics and Modelling
Lianet Monzote, Ana Margarita Montalvo, Lisset Fonseca, Rolando Pérez, Margarita Suárez, Hortensia Rodrı́guez,
Ten thiadiazine derivatives were tested in vitro for antiparasitic effects against both extracellular promastigotes and intracellular amastigotes of Leishmania amazonensis. The results showed that the evaluated compounds exhibited a strong antiproliferative activity on all developmental stages of the parasite. The minimal inhibitory concentration and the 50 % effective concentration values against the promastigote were 2.1-5.1 microg/ml and 0.6-1.8 microg/ml, respectively. The tested compounds caused ...
Tópico(s): Phenothiazines and Benzothiazines Synthesis and Activities
2011 - Thieme Medical Publishers (Germany) | Arzneimittelforschung
Martiniano Bello, Rolando Alberto Rodríguez-Fonseca,
Methotrexate (MTX), an FDA-approved drug employed in the treatment of several types of cancer and autoimmune diseases, is characterized by its poor solubility. Therefore, new strategies have been implemented such as coupling to nanocarriers to increase its solubility. Previous experimental studies have demonstrated complexation of MTX to polyamidoamine of a generation four (PAMAM-G4) dendrimer with a complex stoichiometry of 19/22:1 under neutral conditions, providing important information that can ...
Tópico(s): RNA Interference and Gene Delivery
2019 - Elsevier BV | Journal of Molecular Graphics and Modelling
Maricarmen Hernández‐Rodríguez, Cecilia Flores Clemente, Martha Edith Macías-Pérez, Rolando Alberto Rodríguez-Fonseca, María Inés Nicolás‐Vázquez, Joel Martínez, René Miranda, Martı́n Rosas, Elvia Mera Jiménez,
Tópico(s): Neurological Disease Mechanisms and Treatments
2022 - Elsevier BV | Pharmacological Reports
Produção Nacional
Revisado por pares
Fabiana Azevedo Voorwald, Fábio Albuquerque Marchi, Rolando André Rios Villacis, Carlos Eduardo Fonseca‐Alves, Gilson Hélio Toniollo, Renée Laufer Amorim, Sandra A. Drigo, Sílvia Regina Rogatto,
Cystic endometrial hyperplasia (CEH), mucometra, and pyometra are common uterine diseases in intact dogs, with pyometra being a life threatening disease. This study aimed to determine the gene expression profile of these lesions and potential biomarkers for closed-cervix pyometra, the most severe condition. Total RNA was extracted from 69 fresh endometrium samples collected from 21 healthy female dogs during diestrus, 16 CEH, 15 mucometra and 17 pyometra (eight open and nine closed-cervixes). Global ...
Tópico(s): Veterinary Medicine and Surgery
2015 - Public Library of Science | PLoS ONE
Produção Nacional
Revisado por pares
Renée Laufer Amorim, Carlos Eduardo Fonseca‐Alves, Rolando André Rios Villacis, Sandra Linde, Márcio de Carvalho, Simon J. Larsen, Fábio Albuquerque Marchi, Sílvia Regina Rogatto,
Canine carcinomas have been considered natural models for human diseases; however, the genomic profile of canine prostate cancers (PCs) has not been explored. In this study, 14 PC androgen-receptor-negative cases, 4 proliferative inflammatory atrophies (PIA), and 5 normal prostate tissues were investigated by array-based comparative genomic hybridization (aCGH). Copy number alterations (CNAs) were assessed using the Canine Genome CGH Microarray 4 × 44K (Agilent Technologies). Genes covered by recurrent ...
Tópico(s): Genomic variations and chromosomal abnormalities
2019 - Multidisciplinary Digital Publishing Institute | International Journal of Molecular Sciences
Lianet Monzote Fidalgo, Ana Margarita Montalvo Álvarez, Lisset Fonseca Géigel, Rolando Pérez, Margarita Suárez Navarro, Hortensia Rodríguez Cabrera,
Current therapy for leishmaniasis is not satisfactory. We describe the in vitro antiproliferative effects of new thiadiazine derivatives against Leishmania amazonensis. The compounds were found to be active against the amastigote form of the parasite, inhibiting parasite growing, from 10 to 89%, at a concentration of 100 ng/ml. This activity suggests that thiadiazine derivatives could be considered as potential antileishmanial compounds.
Tópico(s): Synthesis and biological activity
2004 - Instituto Oswaldo Cruz, Ministério da Saúde | Memórias do Instituto Oswaldo Cruz
Miguel Torres-Ruiz, Rolando Quintero, Marco Moreno-Ibarra, Frederico Fonseca,
We use ontologies in this paper to search for alternative representations of geographic objects thus providing a description of these objects in cartographic vector maps. We define ontologies based on two types of concepts (“terminal” and “non-terminal”) and two kinds of relations (“has” and “is-a”). These are the basic elements used to describe a map. We also present a case study in which an ontology for topographic maps is created. Our approach is oriented towards solving heterogeneity and interoperability ...
Tópico(s): Geographic Information Systems Studies
2005 - Springer Science+Business Media | Lecture notes in computer science
Edwin Rolando Jiménez Ruiz, William Fonseca González, Leticia Pazmiño Pesantez,
En este trabajo se cuantificó la biomasa y el carbono almacenado en la cobertura vegetal de un sistema silvopastoril compuesto por pasto (Hyparrhenia rufa) y guasmo (Guazuma ulmifolia) establecido en forma natural en el cantón Balzar de la provincia del Guayas en Ecuador. A través del método destructivo y con un muestreo aleatorio por medio de parcelas anidadas, se evaluó la cantidad de biomasa arbórea y subterránea de árboles de diámetro promedio, la necromasa y la vegetación herbácea. Se desarrollaron ...
Tópico(s): Tree Root and Stability Studies
2019 - Politecnica Salesiana University | La Granja
David R. Lenat, Vincent H. Resh,
... Rivera, Oscar Vásquez-Bolaños, Cinthya Gómez-Castro, Alicia Fonseca-Sánchez, Abad Rodríguez-Rodríguez, Rolando Sánchez-Gutiérrez Ecosystemic Assessment of Surface Water Quality ...
Tópico(s): Aquatic Invertebrate Ecology and Behavior
2001 - University of Chicago Press | Journal of the North American Benthological Society
Rolando Alberto Rodríguez-Fonseca, João Rodrigues, Munoz-Fernandez Maria de los Angeles, Martinez Munoz Alberto, Fragoso Vazquez Manuel Jonathan, Correa Basurto Jose,
Nanomedicine is the application of nanotechnology to medicine. This field is related to the study of nanodevices and nanomaterials applied to various medical uses, such as in improving the pharmacological properties of different molecules. Dendrimers are synthetic nanoparticles whose physicochemical properties vary according to their chemical structure. These molecules have been extensively investigated as drug nanocarriers to improve drug solubility and as sustained-release systems. New therapies ...
Tópico(s): DNA and Nucleic Acid Chemistry
2017 - Bentham Science Publishers | Current Pharmaceutical Design
Produção Nacional
Revisado por pares
Flávia Lima Costa Faldoni, Rolando André Rios Villacis, Luísa Matos do Canto, Carlos Eduardo Fonseca‐Alves, Sarah Santiloni Cury, Simon J. Larsen, Mads Malik Aagaard, Cristiano de Pádua Souza, Cristovam Scapulatempo‐Neto, Cynthia Aparecida Bueno de Toledo Osório, Jan Baumbach, Fábio Albuquerque Marchi, Sílvia Regina Rogatto,
Inflammatory breast cancer (IBC) is a rare and aggressive type of breast cancer whose molecular basis is poorly understood. We performed a comprehensive molecular analysis of 24 IBC biopsies naïve of treatment, using a high-resolution microarray platform and targeted next-generation sequencing (105 cancer-related genes). The genes more frequently affected by gains were MYC (75%) and MDM4 (71%), while frequent losses encompassed TP53 (71%) and RB1 (58%). Increased MYC and MDM4 protein expression levels ...
Tópico(s): RNA modifications and cancer
2020 - Multidisciplinary Digital Publishing Institute | Cancers
Noam Siegelman, Sascha Schroeder, Cengiz Acartürk, Hee-Don Ahn, Svetlana Alexeeva, Simona Amenta, Raymond Bertram, Rolando Bonandrini, Marc Brysbaert, Daria Chernova, Sara Maria Da Fonseca, Nicolas Dirix, Wouter Duyck, Argyro Fella, Ram Frost, Carolina Gattei, Areti Kalaitzi, Nayoung Kwon, Kaidi Lõo, Marco Marelli, Timothy C. Papadopoulos, Athanassios Protopapas, Satu Savo, Diego E. Shalóm, Natalia Slioussar, Roni Stein, Longjiao Sui, Analí Taboh, Veronica Tønnesen, Kerem Alp Usal, Victor Kuperman,
Scientific studies of language behavior need to grapple with a large diversity of languages in the world and, for reading, a further variability in writing systems. Yet, the ability to form meaningful theories of reading is contingent on the availability of cross-linguistic behavioral data. This paper offers new insights into aspects of reading behavior that are shared and those that vary systematically across languages through an investigation of eye-tracking data from 13 languages recorded during ...
Tópico(s): Text Readability and Simplification
2022 - Springer Science+Business Media | Behavior Research Methods
Victor Kuperman, Noam Siegelman, Sascha Schroeder, Cengiz Acartürk, Svetlana Alexeeva, Simona Amenta, Raymond Bertram, Rolando Bonandrini, Marc Brysbaert, Daria Chernova, Sara Maria Da Fonseca, Nicolas Dirix, Wouter Duyck, Argyro Fella, Ram Frost, Carolina Gattei, Areti Kalaitzi, Kaidi Lõo, Marco Marelli, Kelly Nisbet, Timothy C. Papadopoulos, Athanassios Protopapas, Satu Savo, Diego E. Shalóm, Natalia Slioussar, Roni Stein, Longjiao Sui, Analí Taboh, Veronica Tønnesen, Kerem Alp Usal,
Abstract Research into second language (L2) reading is an exponentially growing field. Yet, it still has a relatively short supply of comparable, ecologically valid data from readers representing a variety of first languages (L1). This article addresses this need by presenting a new data resource called MECO L2 (Multilingual Eye Movements Corpus), a rich behavioral eye-tracking record of text reading in English as an L2 among 543 university student speakers of 12 different L1s. MECO L2 includes a test ...
Tópico(s): Text Readability and Simplification
2022 - Cambridge University Press | Studies in Second Language Acquisition
Leonardo Mena‐Rivera, Oscar Vásquez-Bolaños, Cinthya Gómez-Castro, Alicia Fonseca-Sánchez, Abad Rodríguez-Rodríguez, Rolando Sánchez‐Gutiérrez,
Water quality information is essential supporting decision making in water management processes. The lack of information restricts, at some point, the implementation of adequate sanitation, which is still scarce in developing countries. In this study, an ecosystemic water quality assessment was conducted in the Virilla river in Costa Rica, in a section of particular interest for future sanitation development. It included the monitoring of physical, chemical, microbiological and benthic macroinvertebrate ...
Tópico(s): Public Health and Environmental Issues
2018 - Multidisciplinary Digital Publishing Institute | Water
Guadalupe Ortega‐Pierres, Raúl Argüello-García, Marco S. Laredo-Cisneros, Rocío Fonseca-Liñán, Misael Gómez-Mondragón, Rolando Inzunza-Arroyo, David Flores-Benítez, Arturo Raya‐Sandino, Bibiana Chávez-Munguı́a, José Luis Ventura-Gallegos, Alejandro Zentella‐Dehesa, Rosa Marı́a Bermúdez-Cruz, Lorenza González‐Mariscal,
The adhesion of Giardia duodenalis trophozoites to intestinal epithelial cells allows the onset and maintenance of giardiasis. During these interactions, epithelial cells can be committed to apoptosis by enzymes secreted by the parasites, including cysteine proteases that are increasingly identified as virulence factors in parasitic protozoa. In this work, a monoclonal antibody (mAb1G3) raised against G. duodenalis surface components was found to react with a 25 kDa protein expressed in the cell ...
Tópico(s): Toxoplasma gondii Research Studies
2018 - Elsevier BV | International Journal for Parasitology
Jennifer A. Kurth, Amanda L. Miller, Samantha Gross Toews, James R. Thompson, Mónica Cortés, Mukunda Hari Dahal, Inés E. de Escallón, Paula Frederica Hunt, Gordon L. Porter, Diane Richler, Indiana Fonseca, Ruchi Singh, Jan Šiška, Rolando Jr. C. Villamero, Fatma Wangare,
Abstract Every child has the right to an education, including children with disabilities. Research findings from across the globe have shown the benefits of inclusive education, and mandates for providing accessible, inclusive education can be found in national policies and international agreements as well. This article explores the perspectives of 11 international experts on the state of inclusive education in countries spanning 5 continents. Experts participated in a focus group discussion at ...
Tópico(s): Family and Disability Support Research
2018 - | Intellectual and developmental disabilities
Produção Nacional
Revisado por pares
Francisco Elvis Carvalho Souza, Werbet Luiz Almeida da Silva, Andrés O. Salazar, José Alvaro de Paiva, Diego Antonio de Moura Fonsêca, Elmer Rolando Llanos Villarreal,
In order to reduce the costs of implementing the radial position control system of a three-phase bearingless machine with split winding, this article proposes a driving method that uses only two phases of the system instead of the three-phase traditional one. It reduces from six to four the number of inverter legs, drivers, sensors, and current controllers necessary to drive and control the system. To justify the proposal, this new power and control configuration was applied to a 250 W machine controlled ...
Tópico(s): Electric Motor Design and Analysis
2021 - Multidisciplinary Digital Publishing Institute | Energies
Produção Nacional
Revisado por pares
Diego Antonio de Moura Fonseca, Andrés O. Salazar, Elmer Rolando Llanos Villarreal, German Alberto Echaiz Espinoza, Alan C. Q. B. Leite,
The electrical submersible pump (ESP) is widely used in the oil industry as an artificial lift method in deep wells, and its primary application of ESP is to increase the oil flow rate. Information such as the pump intake and discharge pressure, the oil reservoir and motor winding temperature, etc., provide critical data necessary to ensure proper ESP system operation and optimize production. In this article, an ESP downhole parameter monitoring system is proposed. Potentiometers are used to generates ...
Tópico(s): Advanced Data Processing Techniques
2021 - Institute of Electrical and Electronics Engineers | IEEE Access
Rolando Sánchez‐Gutiérrez, Leonardo Mena‐Rivera, Ricardo Sánchez‐Murillo, Alicia Fonseca-Sánchez, Helga Madrigal-Solís,
Tópico(s): Geochemistry and Geologic Mapping
2020 - Springer Science+Business Media | Environmental Geochemistry and Health