Tor‐Christian Johannessen, Rolf Bjerkvig, Berit B. Tysnes,
Glioblastoma is the most malignant and frequent primary brain tumour in adults. Current treatment remains insufficient as these tumours display a diffuse infiltrative growth pattern and tend to recur despite extensive debulking surgery followed by radio- and chemotherapy. The alkylating agents carmustine (1,3-bis-(2-chloroethyl)-1-nitrosourea, or BCNU) and temozolomide (TMZ) are the drugs of choice for adjuvant glioma chemotherapy. However, several independent DNA repair mechanisms can restore the ...
Tópico(s): Epigenetics and DNA Methylation
2008 - Elsevier BV | Cancer Treatment Reviews
Tor‐Christian Johannessen, Rolf Bjerkvig,
Glioblastoma multiforme (GBM; WHO astrocytoma grade IV) is considered incurable owing to its inherently profound resistance towards current standards of therapy. Considerable effort is being devoted to identifying the molecular basis of temozolomide resistance in GBMs and exploring novel therapeutic regimens that may improve overall survival. Several independent DNA repair mechanisms that normally safeguard genome integrity can facilitate drug resistance and cancer cell survival by removing chemotherapy- ...
Tópico(s): Microtubule and mitosis dynamics
2012 - Taylor & Francis | Expert Review of Anticancer Therapy
Ulrike Neckmann, Camilla Wolowczyk, Martina Hall, Eivind Almaas, Jiang Ren, Sen Zhao, Bjarne Johannessen, Rolf I. Skotheim, Geir Bjørkøy, Peter ten Dijke, Toril Holien,
In breast cancer, activation of bone morphogenetic protein (BMP) signaling and elevated levels of BMP-antagonists have been linked to tumor progression and metastasis. However, the simultaneous upregulation of BMPs and their antagonist, and the fact that both promote tumor aggressiveness seems contradictory and is not fully understood.We analyzed the transcriptomes of the metastatic 66cl4 and the non-metastatic 67NR cell lines of the 4T1 mouse mammary tumor model to search for factors that promote ...
Tópico(s): Congenital heart defects research
2019 - BioMed Central | Cell Communication and Signaling
Laura Victoria Schulte-Werning, Anjanah Murugaiah, Bhupender Singh, Mona Johannessen, Rolf Einar Engstad, Nataša Škalko‐Basnet, Ann Mari Holsæter,
An active wound dressing should address the main goals in wound treatment, which are improved wound healing and reduced infection rates. We developed novel multifunctional nanofibrous wound dressings with three active ingredients: chloramphenicol (CAM), beta-glucan (βG) and chitosan (CHI), of which βG and CHI are active nanofiber-forming biopolymers isolated from the cell walls of Saccharomyces cerevisiae and from shrimp shells, respectively. To evaluate the effect of each active ingredient on the ...
Tópico(s): Silk-based biomaterials and applications
2021 - Multidisciplinary Digital Publishing Institute | Pharmaceutics
Rolf Johannessen, S. J. Gale, Michael Asbury,
When the GPS (Global Positioning System) is subjected to interference, the system performance gradually deteriorates as the interfering levels increase. Two modes of interference are discussed in detail, namely, that from transmissions at frequencies close to the GPS frequencies and that from transmissions with a harmonic in the GPS band. It is argued that the former requires RF filtering in the receiver with a quality better than that generally specified. The latter cannot be dealt with in such ...
Tópico(s): Power Line Communications and Noise
1990 - Institute of Electrical and Electronics Engineers | IEEE Aerospace and Electronic Systems Magazine
Jakob Gakkestad, Per Dalsjø, Helge Kristiansen, Rolf Johannessen, Maaike M. Visser Taklo,
A novel conductive adhesive is used to interconnect MEMS test structures with different pad sizes directly to a printed circuit board (PCB) in a medium caliber ammunition fuze. The fuze environment is very demanding, with a setback acceleration exceeding 60,000 g and a centripetal acceleration increasing radially with 9000 g/mm. The adhesive shows excellent mechanical and thermal properties. The mounted MEMS test structures perform well when subjected to rapid temperature cycling according to military- ...
Tópico(s): Advanced MEMS and NEMS Technologies
2010 - SPIE | Journal of Micro/Nanolithography MEMS and MOEMS
Hoang‐Vu Nguyen, Erik Andreassen, Helge Kristiansen, Rolf Johannessen, Nils Høivik, Knut E. Aasmundtveit,
Novel isotropic conductive adhesives (ICAs) filled with metal-coated polymer spheres have been introduced in order to improve the mechanical reliability compared to conventional silver-filled ICAs. The topic of this study is the rheology of an epoxy filled with monodisperse polymer spheres with or without Ag coating. In trials with uncoated spheres, the viscosity increases with increasing sphere fraction, while the sphere diameter (6 vs. 30 μm) only has a minor effect. With 45 vol% of spheres (giving ...
Tópico(s): Epoxy Resin Curing Processes
2012 - Elsevier BV | Materials & Design (1980-2015)
Bruno Laeng, Tim Brennen, Kristin Johannessen, Kirsti Holmen, Rolf Elvestad,
In this single case study of a man (AE) who suffered a right hemisphere stroke we showed the co-existence of neglect within different spatial frames: (a) In left hemispace and (b) in ‘far’ versus ‘near’ space, both as defined from the patient's viewpoint, as well as (c) for the left side of an object (as defined from an object-centred view). In the experiment, AE's latencies to name the colour of two cubes, each located in one hemispace, were measured. In some conditions, the cubes were placed on a table ...
Tópico(s): Visual perception and processing mechanisms
2002 - Elsevier BV | Cortex
Jørgen Smeby, Anita Sveen, Ina A. Eilertsen, Stine A. Danielsen, Andreas Hoff, Peter W. Eide, Bjarne Johannessen, Merete Hektoen, Rolf I. Skotheim, Marianne G. Guren, Arild Nesbakken, Ragnhild A. Lothe,
Abstract TP53 mutations are common in colorectal cancer (CRC). Most TP53 sequencing studies have been restricted to coding regions, but recent studies have revealed that splice mutations can generate transcript variants with distinct tumorigenic and prognostic properties. Here, we performed unrestricted sequencing of all coding sequences and splice regions of TP53 in a single-hospital series of 401 primary CRCs. TP53 splice mutations were detected in 4% of the cases ( N = 16), considerably more frequent ...
Tópico(s): Cancer-related Molecular Pathways
2019 - Springer Nature | Oncogenesis
Rolf Johannessen, Frøydis Oldervoll, Frode Strisland,
Reliable interconnects are essential for microelectronic systems intended for long life times in harsh environment applications. Intermetallic growth accelerates as the temperature increases, and the material system must be carefully selected to avoid mechanically and/or electrically weak connections. The dominating chip metallization is aluminium, and aluminium wire-bonding is therefore recommended to obtain a mono-metallic system at chip level. A suitable substrate metallization compatible with ...
Tópico(s): Electrical and Thermal Properties of Materials
2008 - Elsevier BV | Microelectronics Reliability
Laura Victoria Schulte-Werning, Bhupender Singh, Mona Johannessen, Rolf Einar Engstad, Ann Mari Holsæter,
Increasing prevalence of infected and chronic wounds demands improved therapy options. In this work an electrospun nanofiber dressing with liposomes is suggested, focusing on the dressing's ability to support tissue regeneration and infection control. Chloramphenicol (CAM) was the chosen antibiotic, added to the nanofibers after first embedded in liposomes to maintain a sustained drug release. Nanofibers spun from five different polymer blends were tested, where pectin and polyethylene oxide (PEO) ...
Tópico(s): Advanced Sensor and Energy Harvesting Materials
2024 - Elsevier BV | International Journal of Pharmaceutics
Liv Karen Johannessen, Troels B. Sørensen, Rolf Wynn, P Whitten, Deede Gammon,
This study asks: What theories are employed in telemedicine studies? How might they be categorized in ways that help distinguish the knowledge base of telemedicine?Theories in use were identified from a database of telemedicine-related publications between 1990 and 2005. Eighty-three (5% of 1615) articles referred to a theoretical concept. Grounded Theory procedures were used to analyze and categorize theories, while descriptive statistics were used for supplementary information.The proportion of ...
Tópico(s): Telemedicine and Telehealth Implementation
2008 - Thieme Medical Publishers (Germany) | Methods of Information in Medicine
Stian Lågstad, Sen Zhao, Andreas Hoff, Bjarne Johannessen, Ole Christian Lingjærde, Rolf I. Skotheim,
Abstract Summary Advances in high-throughput RNA sequencing have enabled more efficient detection of fusion transcripts, but the technology and associated software used for fusion detection from sequencing data often yield a high false discovery rate. Good prioritization of the results is important, and this can be helped by a visualization framework that automatically integrates RNA data with known genomic features. Here we present chimeraviz, a Bioconductor package that automates the creation ...
Tópico(s): Cancer-related molecular mechanisms research
2017 - Oxford University Press | Bioinformatics
Erik Larsen, Nils Egil Johannessen, Przemyslaw B. Kowalczuk, Rolf Arne Kleiv,
In this study, a selective flotation process for the separation of K-feldspar from Na-feldspar was developed for the beneficiation of a Norwegian microcline-quartz pegmatite sample. The K-feldspar flotation was performed in alkaline environment (pH 10.5–11.6) with only the addition of NaOH as a modifier and non-ionic Brij58 as a frother, on a fluorine-amine activated bulk feldspar concentrate from the preceding feldspar-quartz separation. The K-feldspar flotation resulted in a K-feldspar concentrate ...
Tópico(s): Geochemistry and Elemental Analysis
2019 - Elsevier BV | Minerals Engineering
Paul Nisner, Rolf Johannessen,
ABSTRACT: This paper gives details of the failure rates and the failure modes experienced with Standard Positioning Service (SPS) GPS receivers certificated for aviation use to the Technical Standard Order (TSO) C-129 specification. These failure rates are significant compared with those from other modern avionics and are comparable to those currently experienced from unscheduled failures in the GPS signals-in-space. The paper also gives details concerning the two-dimensional errors that have been ...
Tópico(s): Embedded Systems and FPGA Applications
2000 - Wiley | NAVIGATION Journal of the Institute of Navigation
Camilla Wolowczyk, Ulrike Neckmann, Miriam R. R. Aure, Martina Hall, Bjarne Johannessen, Sen Zhao, Rolf I. Skotheim, Sonja Andersen, Rosalie T. Zwiggelaar, Tonje S. Steigedal, Ole Christian Lingjærde, Kristine Kleivi Sahlberg, Eivind Almaas, Geir Bjørkøy,
Many breast cancer patients are diagnosed with small, well-differentiated, hormone receptor-positive tumors. Risk of relapse is not easily identified in these patients, resulting in overtreatment. To identify metastasis-related gene expression patterns, we compared the transcriptomes of the non-metastatic 67NR and metastatic 66cl4 cell lines from the murine 4T1 mammary tumor model. The transcription factor nuclear factor, erythroid 2-like 2 (NRF2, encoded by NFE2L2) was constitutively activated in ...
Tópico(s): Cancer-related molecular mechanisms research
2022 - Elsevier BV | Free Radical Biology and Medicine
Rolf Johannessen, Maaike M. Visser Taklo, Martin F. Sunding,
Fine pitch 100-mum electroplated SnAg microbump interconnection technology is presented and discussed for use in microelectromechanical systems (MEMS) based 3-D stacks. Electrochemical deposition (ECD) of copper top side metallization (TSM) is compared to performance of nickel-copper TSM on substrate chips. Nickel-copper was selected for under bump metallization (UBM) of die chips. Lead free Sn3.5%Ag was deposited on the die chip UBM and chip-to-wafer bonded by a standard SnAg reflow process in inert ...
Tópico(s): Semiconductor materials and interfaces
2009 - Institute of Electrical and Electronics Engineers | IEEE Transactions on Advanced Packaging
Tor‐Christian Johannessen, Marek Wagner, Oddbjørn Straume, Rolf Bjerkvig, Hans Petter Eikesdal,
Introduction: Tumor-associated angiogenesis is one of the essential hallmarks underlying cancer development and metastasis. Anti-angiogenic agents accordingly aim to restrain cancer progression by blocking the formation of new vessels, improving the delivery of chemotherapeutic agents to the tumor site and reducing the shedding of metastatic cells into the circulation. This review article addresses some key issues in the use of angiogenesis inhibitors in cancer. Areas covered: The authors review ...
Tópico(s): Cell Adhesion Molecules Research
2012 - Taylor & Francis | Expert Opinion on Therapeutic Targets
Jennifer Munkley, Sebastian Oltean, Daniel Vodák, Brian T. Wilson, Karen E. Livermore, Yan Zhou, Eleanor Star, Vasileios I. Floros, Bjarne Johannessen, Bridget Knight, Paul McCullagh, John McGrath, Malcolm Crundwell, Rolf I. Skotheim, Craig Robson, Hing Y. Leung, Lorna W. Harries, Prabhakar Rajan, Ian G. Mills, David J. Elliott,
... Eleanor Star 2 , Vasileios I. Floros 1 , Bjarne Johannessen 6 , Bridget Knight 7 , Paul McCullagh 8 , John McGrath 9 , Malcolm Crundwell 10 , Rolf I. Skotheim 6 , Craig N. Robson 11 , Hing ...
Tópico(s): Monoclonal and Polyclonal Antibodies Research
2015 - Impact Journals LLC | Oncotarget
Rolf Johannessen, Michael Asbury,
This paper is written to suggest a methodology for assessing the value of particular combinations of INS and GPS, both feeding into a flight management system. The paper considers the complementary nature of GPS and INS sensors and the different levels of integration possible. Those benefits that are of value to civil aviation are then highlighted. The various combinations of INS and GPS sensors are evaluated against a typical transatlantic profile, taking into account certain operational demands ...
Tópico(s): GNSS positioning and interference
1990 - Wiley | NAVIGATION Journal of the Institute of Navigation
Jakob Gakkestad, Per Dalsjø, Helge Kristiansen, Rolf Johannessen, Maaike M. Visser Taklo,
A novel conductive adhesive has been used to interconnect MEMS test structures with different pad sizes directly to a PCB in a medium caliber ammunition fuze. The fuze environment is very demanding with a setback acceleration exceeding 60 000 g and a centripetal acceleration increasing radially with 9000 g/mm. The adhesive shows excellent mechanical and thermal properties. The mounted MEMS test structures have been subjected to rapid temperature cycling according to MIL-STD 883G method 1010.8 test ...
Tópico(s): Semiconductor Lasers and Optical Devices
2010 - SPIE | Proceedings of SPIE, the International Society for Optical Engineering/Proceedings of SPIE
Anita Sveen, Bjarne Johannessen, Manuel R. Teixeira, Ragnhild A. Lothe, Rolf I. Skotheim,
We have previously proposed transcriptome instability as a genome-wide, pre-mRNA splicing-related characteristic of colorectal cancer. Here, we explore the hypothesis of transcriptome instability being a general characteristic of cancer. Exon-level microarray expression data from ten cancer datasets were analyzed, including breast cancer, cervical cancer, colorectal cancer, gastric cancer, lung cancer, neuroblastoma, and prostate cancer (555 samples), as well as paired normal tissue samples from ...
Tópico(s): Cancer-related molecular mechanisms research
2014 - BioMed Central | BMC Genomics
Rolf Anton Klaasen, Erlend Johannessen Egeland, Joe Chan, Karsten Midtvedt, My Svensson, Nils Bolstad, Bengt Fellström, Hallvard Holdaas, Anders Åsberg, Stein Bergan, Nils Tore Vethe, David J. Warren,
Belatacept (Nulojix; Bristol-Myers Squibb, New York, NY) is a biological immunosuppressive drug used for the prophylaxis of acute rejection after renal transplantation. Few studies have described belatacept pharmacokinetics, and the effect of therapeutic drug monitoring has not been investigated. We have developed a drug-capture assay (using drug target) to measure belatacept in serum and applied this assay in a pharmacokinetic study in renal transplant recipients.CD80 was used to trap belatacept ...
Tópico(s): HIV/AIDS drug development and treatment
2018 - Lippincott Williams & Wilkins | Therapeutic Drug Monitoring
... 212 The Institute's Professional Forum Dr. Rolf Johannessen, Dr. Rolf Johannessen STC Technology, Essex, U.K.Search for more papers by this author Dr. Rolf Johannessen, Dr. Rolf Johannessen STC Technology, Essex, U.K.Search for more ...
1990 - Wiley | NAVIGATION Journal of the Institute of Navigation
Karina Standahl Olsen, Birgit Falch, Kjersti Danielsen, Mona Johannessen, Johanna U. Ericson, Inger Thune, Guri Grimnes, Rolf Jorde, Gunnar Skov Simonsen, Anne‐Sofie Furberg,
Vitamin D induces the expression of antimicrobial peptides with activity against Staphylococcus aureus. Thus, we studied the association between serum 25-hydroxyvitamin D (25(OH)D) and S. aureus nasal colonization and carriage. Nasal swabs, blood samples and clinical data from 2,115 women and 1,674 men, aged 30-87 years, were collected in the Tromsø Staph and Skin Study 2007-08, as part of the population-based sixth Tromsø Study. Multivariate logistic regression analyses were stratified by recognized ...
Tópico(s): Drug-Induced Adverse Reactions
2011 - Springer Science+Business Media | European Journal of Clinical Microbiology & Infectious Diseases
Andreas Hoff, Sen Zhao, Bjarne Johannessen, Rolf I. Skotheim,
... Citation Format: Andreas M. Hoff, Sen Zhao, Bjarne Johannessen, Rolf I. Skotheim. Transcriptome analyses reveal fusion transcripts and ...
Tópico(s): Cancer-related molecular mechanisms research
2016 - American Association for Cancer Research | Cancer Research
Karen C. Johannessen, Jan Vander Roost, Håkon Dahle, Siv Hjorth Dundas, Rolf B. Pedersen, Ingunn H. Thorseth,
Tópico(s): Microbial Community Ecology and Physiology
2016 - Elsevier BV | Geochimica et Cosmochimica Acta
Hildegunn Berntsen, Per Eystein Lønning, Dagfinn Ekse, Bjørn Netteland, Dag Clement Johannessen, Rolf K. Berge, Asbjørn M. Svardal,
Tópico(s): Estrogen and related hormone effects
1998 - Springer Science+Business Media | Cancer Chemotherapy and Pharmacology
Tonje Sønstevold, Anne Christine Johannessen, Rolf K. Reed, Gerd Salvesen, Linda Stuhr,
Hyperbaric oxygen therapy (HBOT) has been used to enhance microcirculation and thereby oxygen tension in tissues. The present study aimed to investigate the effect of HBOT on radiation injury in the mandibular area of rats.The left mandibles of rats were irradiated by external radiotherapy (15 Gy every other week for a total of 75 Gy). Four HBOT strategies were used: 2 prophylactic groups receiving HBOT either between each radiation treatment or immediately following terminated radiation treatment, ...
Tópico(s): Oral Health Pathology and Treatment
2017 - Elsevier BV | Oral Surgery Oral Medicine Oral Pathology and Oral Radiology
Michael Asbury, Rolf Johannessen,
State-of-the-art avionics achieves very good reliability, and the electronics in the current generation of communication and navigation satellites is sufficiently good to allow a design-life of around 10 years. Nevertheless, failures will arise. The purpose of failure analysis is to identify the consequences if a particular module does encounter a failure, and to ensure that, by system redundancy or through operational procedures, the effect and/or its probability of occurrence will be acceptably ...
Tópico(s): Air Traffic Management and Optimization
1995 - Cambridge University Press | Journal of Navigation