Alexander Street
Rosa Mistica C. Ignacio, Carla Gibbs, Soohyun Kim, Eun-Sook Lee, Samuel E. Adunyah, Deok‐Soo Son,
// Rosa Mistica C. Ignacio 1 , Carla R. Gibbs 1 , Soohyun Kim 2 , Eun-Sook Lee 3 , Samuel E. ...
Tópico(s): Wnt/β-catenin signaling in development and cancer
2019 - Impact Journals LLC | Oncotarget
Rosa Mistica C. Ignacio, Yuanlin Dong, Syeda M. Kabir, Hyeongjwa Choi, Eun-Sook Lee, Andrew J. Wilson, Alicia Beeghly‐Fadiel, Margaret M. Whalen, Deok‐Soo Son,
// Rosa Mistica C. Ignacio 1 , Yuan-Lin Dong 1 , Syeda M. Kabir 1 , Hyeongjwa Choi 1 , Eun-Sook ...
Tópico(s): Chemokine receptors and signaling
2018 - Impact Journals LLC | Oncotarget
Antonio Ulises Cusihuamán-Puma, Víctor Rodolfo Vert-Gossen, Julia Raquel Medina-Rodríguez, Domingo Santiago Ávalos, Marta Inès Ferreira Gaona, Clarisse Díaz-Reissner,
... vulnerable en el seno familiar en el Barrio Rosa Mística, Mariano Roque Alonso en el 2012. Se utilizó ... en un grupo de adolescentes residentes del Barrio Rosa Mística, área jurisdiccional de la Unidad de Salud Familiar " ...
Tópico(s): Public Health and Social Inequalities
2018 - Universidad Nacional de Asunción | Memorias del Instituto de Investigaciones en Ciencias de la Salud
George Sharbeen, Joshua A. McCarroll, Anouschka Akerman, Chantal Kopecky, Janet Youkhana, John Kokkinos, Jeff Holst, Cyrille Boyer, Mert Erkan, David Goldstein, Paul Timpson, Thomas R. Cox, Brooke A. Pereira, Jessica L. Chitty, Sigrid K. Fey, Arafath K. Najumudeen, Andrew D. Campbell, Owen J. Sansom, Rosa Mistica C. Ignacio, Stephanie Naim, Jie Liu, Nelson Russia, Jungwha Lee, Angela Chou, Amber L. Johns, Anthony J. Gill, Estrella Gonzales‐Aloy, Val Gebski, Yi Fang Guan, Marina Pajic, Nigel Turner, Minoti V. Apte, Thomas P. Davis, Jennifer P. Morton, Koroush S. Haghighi, Jorjina Kasparian, Benjamin J. McLean, Yordanos F. Setargew, Phoebe A. Phillips,
Abstract Cancer-associated fibroblasts (CAF) are major contributors to pancreatic ductal adenocarcinoma (PDAC) progression through protumor signaling and the generation of fibrosis, the latter of which creates a physical barrier to drugs. CAF inhibition is thus an ideal component of any therapeutic approach for PDAC. SLC7A11 is a cystine transporter that has been identified as a potential therapeutic target in PDAC cells. However, no prior study has evaluated the role of SLC7A11 in PDAC tumor stroma ...
Tópico(s): Amino Acid Enzymes and Metabolism
2021 - American Association for Cancer Research | Cancer Research
Taskeen Iqbal Janjua, Aria Ahmed-Cox, Anand Kumar Meka, Friederike M. Mansfeld, Helen Forgham, Rosa Mistica C. Ignacio, Yuxue Cao, Joshua A. McCarroll, Roberta Mazzieri, Maria Kavallaris, Amirali Popat,
The blood brain barrier (BBB) and blood tumour barrier (BTB) remain a major roadblock for delivering therapies to treat brain cancer. Amongst brain cancers, glioblastoma (GBM) is notoriously difficult to treat due to the challenge of delivering chemotherapeutic drugs across the BBB and into the tumour microenvironment. Consequently, GBM has high rates of tumour recurrence. Currently, limited numbers of chemotherapies are available that can cross the BBB to treat GBM. Nanomedicine is an attractive solution ...
Tópico(s): Nanoparticle-Based Drug Delivery
2021 - Royal Society of Chemistry | Nanoscale
John Kokkinos, George Sharbeen, Koroush S. Haghighi, Rosa Mistica C. Ignacio, Chantal Kopecky, Estrella Gonzales‐Aloy, Janet Youkhana, Paul Timpson, Brooke A. Pereira, Shona Ritchie, Elvis Pandžić, Cyrille Boyer, Thomas P. Davis, Lisa M. Butler, David Goldstein, Joshua A. McCarroll, Phoebe A. Phillips,
Abstract The poor prognosis of pancreatic ductal adenocarcinoma (PDAC) is attributed to the highly fibrotic stroma and complex multi-cellular microenvironment that is difficult to fully recapitulate in pre-clinical models. To fast-track translation of therapies and to inform personalised medicine, we aimed to develop a whole-tissue ex vivo explant model that maintains viability, 3D multicellular architecture, and microenvironmental cues of human pancreatic tumours. Patient-derived surgically-resected ...
Tópico(s): Cancer Genomics and Diagnostics
2021 - Nature Portfolio | Scientific Reports
John Kokkinos, Rosa Mistica C. Ignacio, George Sharbeen, Cyrille Boyer, Estrella Gonzales‐Aloy, David Goldstein, Australian Pancreatic Cancer Genome Initiative, Joshua A. McCarroll, Phoebe A. Phillips,
Pancreatic cancer is predicted to be the second leading cause of cancer-related death by 2025. The best chemotherapy only extends survival by an average of 18 weeks. The extensive fibrotic stroma surrounding the tumor curbs therapeutic options as chemotherapy drugs cannot freely penetrate the tumor. RNA interference (RNAi) has emerged as a promising approach to revolutionize cancer treatment. Small interfering RNA (siRNA) can be designed to inhibit the expression of any gene which is important given ...
Tópico(s): Graphene and Nanomaterials Applications
2020 - Elsevier BV | Biomaterials
Rosa Mistica C. Ignacio, Kyung-Bok Joo, Kyungjin Lee,
Recently, alkaline ionized water (AIW) generated by water electrolysis has received increasing attention because of its shown benefits in treatment and prevention of diseases. The Korean and the Japanese governments officially acknowledged the efficacy of AIW as a novel material for the improvement of abnormal intestinal fermentation, chronic diarrhea, gastric hyperacidity and dyspepsia. It was reported that intake of AIW has various beneficial effects such as removal of reactive oxygen species, ...
Tópico(s): Biochemical effects in animals
2020 - Elsevier BV | Journal of Food and Drug Analysis
Rosa Mistica C. Ignacio, Eun-Sook Lee, Andrew J. Wilson, Alicia Beeghly‐Fadiel, Margaret M. Whalen, Deok‐Soo Son,
Ovarian cancer (OC) has the highest mortality rate among gynecological malignancies.Because chemokine network is involved in OC progression, we evaluated associations between chemokine expression and survival in tumor suppressor protein p53 (TP53) wildtype (TP53WT) and mutant (TP53m) OC datasets.TP53 was highly mutated in OC compared to other cancer types.Among OC subtypes, CXCL14 was predominantly expressed in clear cell OC, and CCL15 and CCL20 in mucinous OC.TP53WT endometrioid OC highly expressed ...
Tópico(s): Cytokine Signaling Pathways and Interactions
2018 - | Immune Network
Rosa Mistica C. Ignacio, Carla Gibbs, Eun-Sook Lee, Deok-Soo Son,
Obesity is characterized as an accumulation of adipose tissue mass represented by chronic, low-grade inflammation. Obesity-derived inflammation involves chemokines as important regulators contributing to the pathophysiology of obesity-related diseases such as cardiovascular disease, diabetes and some cancers. The obesity-driven chemokine network is poorly understood. Here, we identified the profiles of chemokine signature between human preadipocytes and adipocytes, using PCR arrays and qRT-PCR. ...
Tópico(s): Chemokine receptors and signaling
2016 - | Immune Network
Rosa Mistica C. Ignacio, Syeda M. Kabir, Eun-Sook Lee, Samuel E. Adunyah, Deok‐Soo Son,
Ovarian cancer is an inflammation-associated malignancy with a high mortality rate. CXCR2 expressing ovarian cancers are aggressive with poorer outcomes. We previously demonstrated that CXCR2-driven ovarian cancer progression potentiated NF-κB activation through EGFR-transactivated Akt. Here, we identified the chemokine signature involved in CXCR2-driven ovarian cancer progression using a mouse peritoneal xenograft model for ovarian cancer spreading with CXCR2-negative (SKA) and positive (SKCXCR2) ...
Tópico(s): Immune cells in cancer
2016 - Public Library of Science | PLoS ONE
Rosa Mistica C. Ignacio, Cheol-Su Kim, Young-Do Kim, Hakmin Lee, Xu-Feng Qi, Soo‐Ki Kim,
While Active Hexose Correlated Compound (AHCC) and CpG oligodeoxynucleotide (ODN) are separately known to modulate oxidative stress and immune responses in cancer patients, the combined effect of these two compounds is unknown. To clarify this, we investigated whether AHCC plus KSK-CpG ODN would be therapeutic in B16 melanoma mouse model, if so, and how in reduction–oxidation (redox) balance and cytokines network. We found that treatment groups (AHCC only, KSK-CpG ODN only and AHCC/KSK-CpG ODN) markedly ...
Tópico(s): Curcumin's Biomedical Applications
2015 - Elsevier BV | Cytokine
Seong Soo A. An, Cheol-Su Kim, Hai-Duong Nguyen, Rosa Mistica C. Ignacio, Jae Heon Kim, Hyeon-Cheol Cho, Eun-Ho Meang, Yuri Kim, Myeong-Kon Kim, Bae-Keun Park, Soo‐Ki Kim,
Abstract: While zinc oxide (ZnO) nanoparticles (NPs) have been recognized to have promising applications in biomedicine, their immunotoxicity has been inconsistent and even contradictory. To address this issue, we investigated whether ZnO NPs with different size (20 or 100 nm) and electrostatic charge (positive or negative) would cause immunotoxicity in vitro and in vivo, and explored their underlying molecular mechanism. Using Raw 264.7 cell line, we examined the immunotoxicity mechanism of ZnO NPs ...
Tópico(s): Graphene and Nanomaterials Applications
2014 - Dove Medical Press | International Journal of Nanomedicine
Soo-Ki Kim, Jae Heon Kim, Cheol-Su Kim, Rosa Mistica C. Ignacio, Dong-Heui Kim, Ma. Easter Joy Sajo, Eun-Ho Meang, Xufeng Qi, Seong‐Eun Park, Yuri Kim, Myeong-Kon Kim, Kyu‐Jae Lee, Seong Soo A. An,
Abstract: Silicon dioxide (SiO 2 ) nanoparticles (NPs) have been widely used in the biomedical field, such as in drug delivery and gene therapy. However, little is known about the biological effects and potential hazards of SiO 2 . Herein, the colloidal SiO 2 NPs with two different sizes (20 nm and 100 nm) and different charges (L-arginine modified: SiO 2 EN20[R] , SiO 2 EN100[R] ; and negative: SiO 2 EN20[-] , SiO 2 EN100[-] ) were orally administered (750 mg/kg/day) in female C57BL/6 mice for 14 days. Assessments ...
Tópico(s): Graphene and Nanomaterials Applications
2014 - Dove Medical Press | International Journal of Nanomedicine
Rosa Mistica C. Ignacio, Cheol-Su Kim, Soo‐Ki Kim,
It is widely accepted that chronic inflammation contributes to the pathogenesis of obesity.Researchers have recently discovered that increased inflammatory cytokines and the infiltration and activation of macrophage cells in the adipose tissue are related to chronic obesity.This immunologic dysregulation has led to the development of the classical pro-inflammatory paradigm.However, since chronic inflammation associated with obesity is more than just the overproduction of pro-inflammatory cytokines, ...
Tópico(s): Adipose Tissue and Metabolism
2014 - | Journal of Lifestyle Medicine
Yang-Suk Yoon, Ma. Easter Joy Sajo, Rosa Mistica C. Ignacio, Soo‐Ki Kim, Cheol-Su Kim, Kyu‐Jae Lee,
Atopic dermatitis (AD) is a chronically relapsing, pruritic, eczematous skin disorder accompanying allergic inflammation. AD is triggered by oxidative stress and immune imbalance. In the present study, we investigated the effect of drinking hydrogen water (HW) on 2,4-dinitrochlorobenzene (DNCB)-induced atopic dermatitis in NC/Nga mice and found that HW ameliorated DNCB-induced AD-like clinical symptoms. In line with this, the level of reactive oxygen species in the HW group was significantly inhibited ...
Tópico(s): Circadian rhythm and melatonin
2014 - Pharmaceutical Society of Japan | Biological and Pharmaceutical Bulletin
Rosa Mistica C. Ignacio, Tae-Young Kang, Cheol-Su Kim, Soo‐Ki Kim, Young-Chul Yang, Joon-Hyung Sohn, Kyu‐Jae Lee,
Whether or not alkaline reduced water (ARW) has a positive effect on obesity is unclear. This study aims to prove the positive effect of ARW in high-fat (HF) diet-induced obesity (DIO) in C57BL/6 mice model. Toward this, obesity was induced by feeding the C57BL/6 male mice with high-fat diet (w/w 45% fat) for 12 weeks. Thereafter, the animals were administered with either ARW or tap water. Next, the degree of adiposity and DIO-associated parameters were assessed: clinico-pathological parameters, biochemical ...
Tópico(s): Diet and metabolism studies
2013 - Pharmaceutical Society of Japan | Biological and Pharmaceutical Bulletin
Rosa Mistica C. Ignacio, Yang-Suk Yoon, Ma. Easter Joy Sajo, Cheol-Su Kim, Dong-Heui Kim, Soo Ki Kim, Kyu Jae Lee,
Tópico(s): Medical and Biological Ozone Research
2013 - Springer Science+Business Media | Molecular & Cellular Toxicology
... signify Mary herself. She is the mystic rose (rosa mistica) of the Loretan litany, the lily among thorns ( ...
Tópico(s): Medieval Literature and History
2004 - Johns Hopkins University Press | Spiritus
Rosa Mistica C. Ignacio, Hyun-Suk Kwak, Young-Uk Yun, Ma. Easter Joy Sajo, Yang-Suk Yoon, Cheol-Su Kim, Soo‐Ki Kim, Kyu‐Jae Lee,
Hydrogen water (HW) produced by electrolysis of water has characteristics of extremely low oxidation-reduction potential (ORP) value and high dissolved hydrogen (DH). It has been proved to have various beneficial effects including antioxidant and anti-inflammatory effects; however, HW effect on atopic dermatitis (AD), an inflammatory skin disorder, is poorly documented. In the present study, we examined the immunological effect of drinking HW on Dermatophagoides farinae -induced AD-like skin in NC/Nga ...
Tópico(s): Circadian rhythm and melatonin
2013 - Hindawi Publishing Corporation | Evidence-based Complementary and Alternative Medicine
Rosa Mistica C. Ignacio, Carla Gibbs, Eun-Sook Lee, Deok‐Soo Son,
Triple-negative breast cancer (TNBC) is aggressive and typically has a poor prognosis. Chemokines have chemoattractant potential for cancer metastasis. Here, we investigated the chemokine signatures in BC subtypes and the underlying mechanisms that enhance proinflammatory chemokines in TNBC. Analysis from microarray dataset revealed that basal-like BC subtype including TNBC expressed dominantly proinflammatory chemokines, such as CXCL1 and 8, compared to non-TNBC. Chemokine PCR array confirmed the ...
Tópico(s): Angiogenesis and VEGF in Cancer
2018 - Impact Journals LLC | Oncotarget
Rosa Mistica C. Ignacio, Cheol-Su Kim, Soo‐Ki Kim,
Tópico(s): Immunotherapy and Immune Responses
2014 - Springer Science+Business Media | Molecular & Cellular Toxicology
Hyeongjwa Choi, Rosa Mistica C. Ignacio, Eun-Sook Lee, Andrew J. Wilson, Dineo Khabele, Deok‐Soo Son,
Tumor necrosis factor-a (TNF) is well known to be involved in the immune system and ovarian inflammation.Ovarian cancer is an inflammation-related malignancy that lacks early screening strategies, resulting in late diagnosis followed by high mortality.Based on our previous data, TNF induced abundant serum amyloid A (SAA), an acute phase protein linked to inflammation, in ovarian granulosal cells.To date, the regulation and expression of SAA in ovarian cancer is not fully elucidated.Here, we investigated ...
Tópico(s): Skin and Cellular Biology Research
2017 - | Immune Network
Rosa Mistica C. Ignacio, Eun-Sook Lee, Andrew J. Wilson, Alicia Beeghly‐Fadiel, Margaret M. Whalen, Deok‐Soo Son,
One-fifth of cancer deaths are associated with obesity. Because the molecular mechanisms by which obesity affects the progression of ovarian cancer (OC) are poorly understood, we investigated if obesity could promote the progression of OC cells using the postmenopausal ob/ob mouse model and peritoneal dissemination of mouse ID8 OC cells. Compared to lean mice, obese mice had earlier OC occurrence, greater metastasis throughout the peritoneal cavity, a trend toward shorter survival, and higher circulating ...
Tópico(s): Endometrial and Cervical Cancer Treatments
2018 - | Immune Network
Rosa Mistica C. Ignacio, Eun-Sook Lee, Deok‐Soo Son,
Ovarian cancer (OC), the deadliest gynecological cancer, results in poor overall survival, urgently requiring a novel therapeutic approach.As cumulative exposures to endotoxins decreased OC risk epidemiologically, we evaluated if LPS, a Toll-like receptor 4 agonist known as active component of endotoxins, could increase survival in the murine peritoneal dissemination model of SKOV-3 OC cells.LPS significantly increased the mean survival time of more than 116 days compared with 63 days in the control. ...
Tópico(s): Immune cells in cancer
2019 - | Immune Network
Hyeongjwa Choi, Rosa Mistica C. Ignacio, Eun-Sook Lee, Katherine F. Roby, Paul F. Terranova, Deok‐Soo Son,
Tumor necrosis factor-α (TNF-α) induces serum amyloid A (SAA) 3 among acute-phase proteins in mouse granulosa cells by activating NF-κB signaling via p55 TNF-α receptor type 1.However, the localization of SAA3 within the ovary is unknown.Here we investigated ovarian localization of SAA3 in a mouse ovulation model and in response to IL-1β, a proinflammatory mediator.For the ovulation model, equine chorionic gonadotropin (eCG; 2.5 IU) was administered to mice subcutaneously (sc) to stimulate follicular ...
Tópico(s): Kruppel-like factors research
2017 - | Immune Network
Produção Nacional
Revisado por pares
Caline Mendes de Araújo, Arthur Valverde,
... analisar as principais modificações ocorridas na comunidade da Rosa Mística, desde sua origem, na década de 1940, até ... cidade. A partir da década de 1980, a Rosa Mística, ou “Buraco da Jia” como era então conhecida, ...
Tópico(s): Urban Development and Societal Issues
2013 - UNIVERSIDADE ESTADUAL DE MARINGÁ | Boletim de Geografia
Produção Nacional
Revisado por pares
... antiga Favela Buraco da Jia (denominada também como Rosa Mística) localizada na cidade de Campina Grande. Esse espaço ...
Tópico(s): Urban Development and Societal Issues
2019 - Postgraduate Program in Tourism of the Federal University of Rio Grande do Norte | Revista de Geociências do Nordeste
Madhusmita Dhupal, Cheol-Su Kim, Rosa Mistica C. Ignacio, Diptiranjan Tripathy, Soo‐Ki Kim,
Tópico(s): Phytase and its Applications
2017 - Springer Science+Business Media | Molecular & Cellular Toxicology