Cedric Gondro, J. H. J. van der Werf, Ben J. Hayes,
... Networks Bruno Dourado Valente and Guilherme Jordao de Magalhaes Rosa 22. Epistasis, Complexity, and Multifactor Dimensionality Reduction Qinxin ...
Tópico(s): Genetic Associations and Epidemiology
2013 - Springer Science+Business Media | Methods in molecular biology
Produção Nacional
Revisado por pares
Paola Pinheiro Kahwage, Mariana Paes Leme Ferriani, João M. Furtado, Luciana Martins de Carvalho, Gecilmara Salviato Pileggi, Francisco Hugo Rodrigues Gomes, Maria Teresa Terreri, Cláudia Saad Magalhães, Rosa Maria Rodrigues Pereira, Silvana Sacchetti, Roberto Marini, Eloísa Bonfá, Clóvis A. Silva, Virgínia Paes Leme Ferriani,
The aim of this study is to assess uveitis prevalence in a large cohort of childhood-onset systemic lupus erythematosus (cSLE) patients. A retrospective multicenter cohort study including 852 cSLE patients was performed in ten pediatric rheumatology centers (Brazilian cSLE group). An investigator meeting was held and all participants received database training. Uveitis was diagnosed through clinical assessment by the uveitis expert ophthalmologist of each center. Patients with and without uveitis ...
Tópico(s): Autoimmune and Inflammatory Disorders Research
2017 - Springer Science+Business Media | Clinical Rheumatology
Paolo Giardullo, Federico Neresini, Esther Marín‐González, Cristina Luı́s, Joana Magalhães, Rosa Arias,
Citizen Science is believed to contribute significantly to the democratisation of science, engaging non-scientists in scientific research. Participatory approaches to science communication share the same interest through public participation and public engagement. In the attempt to connect these two debates both theoretically and empirically, we provide an analysis of the communication tools and strategies used by 157 Citizen Science projects across the EU, UK, and Switzerland. Our analysis reports ...
Tópico(s): Animal and Plant Science Education
2023 - Sissa Medialab | Journal of Science Communication
Produção Nacional
Revisado por pares
Giovanna Revilla, Monica de Pablo Pons, Lucía Baila-Rueda, Annabel García‐León, David Santos, Ana Cenarro, Marcelo Magalhães, Rosa Blanco, Antonio Moral, José Ignacio Arias Pérez, Gerard Sabé, Cintia González, Victòria Fusté, Enrique Lerma, Manuel dos Santos Faria, Alberto de Leiva, Rosa Corcoy, Joan Carles Escolà‐Gil, Eugènia Mato,
Abstract Cholesterol mediates its proliferative and metastatic effects via the metabolite 27-hydroxycholesterol (27-HC), at least in breast and endometrial cancer. We determined the serum lipoprotein profile, intratumoral cholesterol and 27-HC levels in a cohort of patients with well-differentiated papillary thyroid carcinoma (PTC; low/intermediate and high risk), advanced thyroid cancers (poorly differentiated, PDTC and anaplastic thyroid carcinoma, ATC) and benign thyroid tumors, as well as the expression ...
Tópico(s): Estrogen and related hormone effects
2019 - Nature Portfolio | Scientific Reports
Luísa Magalhães, Rosa Freitas, Annabelle Dairain, Xavier de Montaudouin,
Bivalve populations display fluctuating densities resulting in different interactions among them and with their environment. Using the edible cockle ( Cerastoderma edule ) as a model, we investigated two alternative hypotheses concerning the effect of density on individual infection intensity by trematode parasites. Considering that these parasites infect cockles through filtration activity, our first hypothesis was that high host density will have a dilution effect so that infection intensity decreases ...
Tópico(s): Parasites and Host Interactions
2016 - Cambridge University Press | Journal of the Marine Biological Association of the United Kingdom
Luísa Magalhães, Rosa Freitas, Xavier de Montaudouin,
Tópico(s): Marine and fisheries research
2016 - Springer Science+Business Media | Marine Biology
Luísa Magalhães, Rosa Freitas, Xavier de Montaudouin,
Tópico(s): Marine Bivalve and Aquaculture Studies
2015 - Springer Science+Business Media | Parasitology Research
Elena F. Burguera, Á. Vela-Anero, Joana Magalhães, Rosa Meijide-Faílde, Francisco J. Blanco,
Hydrogen sulfide (H2S), the third gasotransmitter together with NO and CO, is emerging as a regulator of inflammation. To test if it might offer therapeutic value in the treatment of osteoarthritis (OA) we evaluated the effects of two exogenous sources of H2S, NaSH and GYY4137, on inflammation and catabolic markers that characterize OA.Human chondrocytes (CHs) were isolated from OA tissue. Cells were stimulated with a pro-inflammatory cytokine (interleukin-1β, IL1β, 5 ng/ml) and the ability of the two ...
Tópico(s): Eicosanoids and Hypertension Pharmacology
2014 - Elsevier BV | Osteoarthritis and Cartilage
Produção Nacional
Revisado por pares
Elizabeth De Francesco Daher, Rafael SA Lima, Geraldo Bezerra da Silva, Eveline C. Silva, Nahme NN Karbage, Raquel S Kataoka, Paulo C Carvalho Júnior, Max M Magalhães, Rosa MS Mota, Alexandre Braga Libório,
INTRODUCTION: leptospirosis is a zoonosis of worldwide importance. The disease is endemic in Brazil. This study was conducted to describe the clinical and laboratory presentation of leptospirosis in a metropolitan city of Brazil. METHODS: this is a retrospective study including 201 consecutive patients with leptospirosis admitted to tertiary hospitals in Fortaleza, Brazil, between 1985 and 2006. All patients had clinical and epidemiological data suggestive of leptospirosis, and positive laboratorial ...
Tópico(s): Viral Infections and Vectors
2010 - Elsevier BV | The Brazilian Journal of Infectious Diseases
Produção Nacional
Revisado por pares
Elizabeth De Francesco Daher, Rafael Siqueira Athayde Lima, Geraldo Bezerra da Silva, Eveline C. Silva, N Karbage, Raquel S. Kataoka, Paulo C. Carvalho Júnior, Max M. Magalhães, Rosa Maria Salani Mota, Alexandre Braga Libório,
Leptospirosis is a zoonosis of worldwide importance. The disease is endemic in Brazil. This study was conducted to describe the clinical and laboratory presentation of leptospirosis in a metropolitan city of Brazil. This is a retrospective study including 201 consecutive patients with leptospirosis admitted to tertiary hospitals in Fortaleza, Brazil, between 1985 and 2006. All patients had clinical and epidemiological data suggestive of leptospirosis, and positive laboratorial test for leptospirosis ( ...
Tópico(s): Viral Infections and Vectors
2010 - Elsevier BV | The Brazilian Journal of Infectious Diseases
Produção Nacional
Revisado por pares
Elizabeth De Francesco Daher, Geraldo Bezerra da Silva, N Karbage, Paulo C. Carvalho, Raquel S. Kataoka, Eveline C. Silva, Max M. Magalhães, Rosa Maria Salani Mota, Sônia M. H. A. Araújo, O Gutiérrez-Adrianzén, Alexandre Braga Libório,
Acute kidney injury (AKI) occurs in 10 to 60% of patients with leptospirosis. The aim of this study is to investigate markers for oliguric AKI in leptospirosis.A retrospective study was performed with 196 consecutive patients with leptospirosis-associated AKI. These patients were categorized into either oliguric or non-oliguric according to their urine output. Clinical and laboratory characteristics were compared between the two groups.Among these patients, 64 (32.6%) were oliguric and 132 (67.4%) ...
Tópico(s): Leptospirosis research and findings
2009 - Karger Publishers | Nephron Clinical Practice
Produção Nacional
Francisco W. R. Santos, Sílvia Maria Meira Magalhães, Rosa Maria Salani Mota, Maria Helena Pitombeira,
Alloimmunisation following red cell transfusion is a complication in patients with chronic diseases requiring multiple transfusions. The aim of this study was to determine the frequency of alloimmunisation, to identify involved alloantibodies, to establish risk factors and to quantify the alloimmunisation risk in patients with acute disorders who received red cell transfusion at the Instituto Dr. José Frota from January 1999 to January 2001. Of the 5,690 recipients who received 16,547 units of red ...
Tópico(s): Erythrocyte Function and Pathophysiology
2007 - Elsevier BV | Revista Brasileira de Hematologia e Hemoterapia
Luísa Magalhães, Rosa Freitas, Xavier de Montaudouin,
Bivalve stocks have been decreasing in the last decades largely due to emergent diseases and consequent mass mortality episodes. Cerastoderma edule (the edible cockle) is one of the most exploited bivalves in Europe and is among the most common hosts for trematodes, the most prevalent macroparasites in coastal waters but yet poorly studied. Therefore, in the present study, this bivalve species was used as host model to determine if trematode infection exerts a negative effect on bivalve energy metabolism ...
Tópico(s): Parasites and Host Interactions
2020 - Elsevier BV | Journal of Invertebrate Pathology
Sofía Xavier, Sara Monteiro, Joana Magalhães, Bruno Rosa, Maria João Moreira, José Cotter,
Aim: To compare the findings and completion rate of Pill-Cam ® SB2 and SB3.Methods: This was a retrospective single-center study that included 357 consecutive small bowel capsule endoscopies (SBCE), 173 SB2 and 184 SB3.The data collected included age, gender, capsule type (PillCam ® SB2 or SB3), quality of bowel preparation, completion of the examination, gastric and small bowel transit time, small bowel findings, findings in segments other than the small bowel and the detection of specific anatomical ...
Tópico(s): Gastrointestinal disorders and treatments
2017 - Arán Ediciones | Revista Española de Enfermedades Digestivas
Produção Nacional
Revisado por pares
Ana Carolina Cabral de Paula Machado, Lívia de Castro Magalhães, Suelen Rosa de Oliveira, Maria Cândida Ferrarez Bouzada,
Tópico(s): Infant Health and Development
2019 - Elsevier BV | Early Human Development
Produção Nacional
Revisado por pares
Yankee C. Magalhães, Maria Rosa Quaresma Bomfim, Luciane C. Melônio, Patrícia C. S. Ribeiro, Lécia M. Cosme, Cristianne Roberta Rhoden, Sirlei Garcia Marques,
In this study, we isolated and phenotypically identified 108 yeast strains from various clinical specimens collected from 100 hospitalized patients at three tertiary hospitals in São Luís-Maranhão, Brazil, from July to December 2010. The isolates were analyzed for their susceptibility to four of the most widely used antifungal agents in the surveyed hospitals, amphotericin B, fluconazole, 5-flucytosine and voriconazole. The species identified were Candida albicans (41.4%), Candida tropicalis (30.1%), ...
Tópico(s): Nail Diseases and Treatments
2015 - Springer Nature | Brazilian Journal of Microbiology
Produção Nacional
Revisado por pares
Renato Socodato, Cristiane Rosa Magalhães, Roberto Paes‐de‐Carvalho,
Abstract Glutamate signaling in the mature retinal tissue is very important for accurate sensory decoding by retinal neurons and orchestrates the fine‐tuned output from the retina to higher‐order centers at the cerebral cortex. In this study, we show that glutamate induces a rapid extracellular‐regulated kinase and cAMP‐responsive element binding protein (CREB) phosphorylation in cultured developing retinal neurons. This process is reliant on α‐amino‐3‐hydroxy‐5‐methylisoxazole‐4‐propionate receptors ...
Tópico(s): Photoreceptor and optogenetics research
2008 - Wiley | Journal of Neurochemistry
Produção Nacional
Revisado por pares
Daniela Rosa Magalhães Gotardo, Edna Strauss, Maria‐Cristina D. Teixeira, Marcel Cerqueira César Machado,
Abstract Aim: A positive effect of liver transplantation on health‐related quality of life (HRQOL) has been well documented in previous studies using generic instruments. Our aim was to re‐evaluate different aspects of HRQOL before and after liver transplantation with a relatively new questionnaire the ‘liver disease quality of life’ (LDQOL). Methods: The LDQOL and the Short Form 36 (SF‐36) questionnaires were applied to ambulatory patients, either in the transplant list ( n =65) or after 6 months to 5 ...
Tópico(s): Organ Transplantation Techniques and Outcomes
2007 - Wiley | Liver International
Produção Nacional
Revisado por pares
Mílton Marques Fernandes, Marcos Gervásio Pereira, Luís Mauro Sampaio Magalhães, Adriano Rosa Cruz, Rômulo Guimarães Giácomo,
Este trabalho teve como objetivo avaliar o aporte e a decomposição da serapilheira em áreas de floresta secundária espontânea, plantio de sabiá (Mimosa caesalpiniaefolia Benth.) e plantio de andiroba (Carapa guianensis Aubl.). Para avaliação do aporte de serapilheira, foram instalados dez coletores cônicos sendo o aporte avaliado durante o período de outubro de 2003 a setembro de 2004. Posteirormente, foi feita a quantificação dos macronutrientes (N, P e K). A avaliação da taxa de decomposição foi ...
Tópico(s): Growth and nutrition in plants
2006 - UNIVERSIDADE FEDERAL DE SANTA MARIA | Ciência Florestal
Produção Nacional
Revisado por pares
Cristiane Rosa Magalhães, Renato Socodato, Roberto Paes‐de‐Carvalho,
Nitric oxide (NO) is an intercellular messenger involved in many physiological and pathological processes of vertebrate and invertebrate animal tissues. In the embryonic chick retina, nitric oxide synthase (NOS) activity and a system for l-arginine transport between neurons and glial cells were described, supporting the idea that nitric oxide is a critical molecule during retinal development. In the present work we show that nitric oxide is a modulator of cell proliferation in chick embryo retina. ...
Tópico(s): Renin-Angiotensin System Studies
2005 - Wiley | International Journal of Developmental Neuroscience
Produção Nacional
Revisado por pares
Laylah Kelre Costa Magalhães, Henrique Silveira, Suzane Ribeiro Prestes, Laylah Kelre Costa Magalhães, Rosa Amélia Gonçalves Santana, Rajendranath Ramasawmy, Josué Costa Oliveira, Cláudia Roque, R. C. A. Silva, Nelson Ferreira Fé, R. Duarte, Marcel Gonçalves Maciel, Jessica Vanina Ortiz, Railton Oliveira Morais, Wuelton Marcelo Monteiro, Jorge Augusto de Oliveira Guerra, Maria Graças V.B. Guerra,
Abstract In the Amazon region, Trypanosoma cruzi transmission cycles involve a great diversity of Triatominae vectors and mammal reservoirs. Some Rhodnius spp. mainly inhabit palm trees that act as microhabitats for hosts and vectors. The current study aimed to describe aspects of the bio‐ecology of the vectors and reservoirs of T. cruzi in relation to human populations resident near areas with large quantities of palm trees, in rural, peri‐urban and urban collection environments, located in the ...
Tópico(s): Insect symbiosis and bacterial influences
2021 - Wiley | Medical and Veterinary Entomology
Sofía Xavier, Joana Magalhães, Bruno Rosa, Maria João Moreira, José Cotter,
Iron deficiency anemia remains one of the main indications to perform small bowel capsule endoscopy. Literature suggests that diagnostic yield is influenced by patient's age but with conflicting results regarding age cutoff.We aimed to clarify the differences in diagnostic yield and incidence of specific findings according to age.Retrospective single-center study including 118 patients performing small bowel capsule endoscopy in the study of iron deficiency anemia. Videos were reviewed and small ...
Tópico(s): Esophageal and GI Pathology
2018 - Instituto Brasileiro de Estudos e Pesquisas de Gastroenterologia (IBEPEGE) | Arquivos de Gastroenterologia
Susana Silva, Regina Magalhães, Rosa Ana Pérez-Herrera, Manuel López-Amo, Manuel B. Marques, Orlando Frazão,
The effect of an erbium-doped fiber amplifier (EDFA) placed inside the fiber ring of a cavity ring down (CRD) configuration is studied. The limitations and advantages of this configuration are discussed, and the study of the ring-down time as a function of the current applied and gain to the EDFA is also presented. In this case, the power fluctuations in the output signal are strongly dependent on the cavity ring-down time with the EDFA gain.
Tópico(s): Semiconductor Lasers and Optical Devices
2016 - Springer Nature | Photonic Sensors
Produção Nacional
Revisado por pares
Fabiano T. Amorim, Ana Carolina Vimieiro Gomes, Christiano A. Machado‐Moreira, Flávio de Castro Magalhães, Márcia Rosa, Luciano Sales Prado, Luiz Oswaldo Carneiro Rodrigues,
The purpose of this study was to investigate whether whole-body sweat rate induced by exercise (SRex) at the same oxygen uptake could be correlated with individual maximum oxygen uptake (peak oxygen uptake (V˙O2peak)). A secondary purpose was to examine the relationship between SRex and local sweat rate induced by pilocarpine on the forearm at rest (SRpilo). Nine healthy young males (V˙O2peak 55.2 (12.3) mL min−1 kg−1, mean (SD); 43.3–76.1 mL min−1 kg−1, range), acclimatized to a tropical climate had their ...
Tópico(s): Cardiovascular and exercise physiology
2006 - Elsevier BV | Journal of Thermal Biology
Produção Nacional
Lúcio Vilar, Júlio Abucham, José Luciano Albuquerque, Luiz Antônio de Araújo, Monalisa Ferreira Azevedo, César Luiz Boguszewski, Luíz Augusto Casulari, Malebranche B. C. Cunha, Mauro Antônio Czepielewski, Felipe Henning Gaia Duarte, Manuel dos Santos Faria, Mônica R. Gadelha, Heraldo Mendes Garmes, Andréa Glezer, Maria Helane Costa Gurgel Castelo, Raquel S. Jallad, Manoel Ricardo Alves Martins, Paulo Augusto Carvalho Miranda, Renan Magalhães Montenegro, Nina Rosa Castro Musolino, Luciana Ansaneli Naves, Antônio Ribeiro‐Oliveira, Cintia M.S. Silva, Camila Viecceli, Marcello D. Bronstein,
Prolactinomas are the most common pituitary adenomas (approximately 40% of cases), and they represent an important cause of hypogonadism and infertility in both sexes. The magnitude of prolactin (PRL) elevation can be useful in determining the etiology of hyperprolactinemia. Indeed, PRL levels > 250 ng/mL are highly suggestive of the presence of a prolactinoma. In contrast, most patients with stalk dysfunction, drug-induced hyperprolactinemia or systemic diseases present with PRL levels < 100 ng/mL. However, ...
Tópico(s): Neuroendocrine Tumor Research Advances
2018 - Brazilian Society of Endocrinology and Metabolism | Archives of Endocrinology and Metabolism
Produção Nacional
Revisado por pares
Denise Schrama, Marco Cerqueira, Cláudia Raposo de Magalhães, Ana M. Rosa da Costa, Tune Wulff, Amparo Gonçalves, Carolina Camacho, Rita Colen, Flávio Augusto Leão da Fonseca, Pedro M. Rodrigues,
The quality of fish flesh depends on the skeletal muscle's energetic state and delaying energy depletion through diets supplementation could contribute to the preservation of muscle's quality traits and modulation of fish allergens. Food allergies represent a serious public health problem worldwide with fish being one of the top eight more allergenic foods. Parvalbumins, have been identified as the main fish allergen. In this study, we attempted to produce a low allergenic farmed fish with improved ...
Tópico(s): Insect Utilization and Effects
2018 - Frontiers Media | Frontiers in Physiology
Tânia Soares Martins, Sandra Magalhães, Ilka Martins Rosa, Jonathan Vogelgsang, Jens Wiltfang, Ivonne Delgadillo, José Catita, Odete A. B. da Cruz e Silva, Alexandra Nunes, Ana Gabriela Henriques,
Alzheimer's disease (AD) diagnosis is based on psychological and imaging tests but can also include monitoring cerebrospinal fluid (CSF) biomarkers. However, CSF based-neurochemical approaches are expensive and invasive, limiting their use to well-equipped settings. In contrast, blood-based biomark ers are minimally invasive, cost-effective, and a widely accessible alternative. Blood-derived exosomes have recently emerged as a reliable AD biomarker source, carrying disease-specific cargo. Fourier- ...
Tópico(s): Spectroscopy and Chemometric Analyses
2020 - IOS Press | Journal of Alzheimer s Disease
Pedro B. Júdice, João P. Magalhães, Gil B. Rosa, Duarte Henriques‐Neto, Megan Hetherington‐Rauth, Luís B. Sardinha,
Evidence on correlates relies on subjective metrics and fails to include correlates across all levels of the ecologic model. We determined which correlates best predict sensor-based physical activity (PA), sedentary time (ST), and self-reported cell phone screen time (CST) in a large sample of youth, while considering a multiplicity of correlates.Using sensor-based accelerometry, we assessed the PA and ST of 2179 youths. A χ2 automatic interaction detection algorithm was used to hierarchize the correlates ...
Tópico(s): Mobile Health and mHealth Applications
2020 - Elsevier BV | Journal of sport and health science/Journal of Sport and Health Science
Produção Nacional
Revisado por pares
Karine Zortéa, Pedro Vieira da Silva Magalhães, Adriane Ribeiro Rosa, David Freitas de Lucena, Lísia Rejane Guimarães, Lenise Peixoto Petter Francesconi, Mariana Pedrini, Júlio Cesar Walz, Clarissa Severino Gama, Flávio Kapczinski, Paulo Belmonte‐de‐Abreu,
ObjectiveMany studies have documented the high rates of functional impairment among patients with schizophrenia. The majority of the available instruments used to assess functioning, however, focus on global measures of functional recovery rather than specific domains of psychosocial functioning. Most of these instruments have important limitations regarding use in psychiatry. The aim of the present study was to evaluate the psychometric properties of the Brazilian version of the Functioning Assessment ...
Tópico(s): Mental Health and Psychiatry
2012 - Elsevier BV | Value in Health Regional Issues
Produção Nacional
Revisado por pares
S Macedo, Valéria Magalhães Aguiar, PF Rosa, IT Ladeia, YK Castro, Leandro A. Ferreira, DR De Melo, LG Rezende,
Some trials have shown that statins in the acute phase of aSAH reduce the incidence, morbidity and mortality of cerebral vasospasm. Independent of their cholesterol-lowering effect, statins have multiple biological properties, including downregulating inflammation and upregulating endothelial NO synthase. The purpose of this study is to evaluate the potential of sinvastatin (SVT) as prevention against vasospasm.
Tópico(s): Acute Ischemic Stroke Management
2012 - BioMed Central | Critical Care